| Interacting proteins: P05121 and P08254 |
Pubmed |
SVM Score :0.54473388 |
| Inactivation of plasminogen activator inhibitor 1 by specific proteolysis with stromelysin 1 ( MMP 3 ) . 0.54473388^^^ |
|
| Interacting proteins: P05121 and P08254 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : The aim of the study was to investigate the effect of functional polymorphisms in promoters of matrix metalloproteinase ( MMP ) 2 , MMP 3 , MMP 9 , MMP 12 and plasminogen activator inhibitor ( PAI ) 1 genes on the growth rate of small abdominal aortic aneurysms ( AAA ) . ^^^ They also provided a DNA sample for analysis of the 1306 C > T , 1171 5A > 6A , 1562 C > T , 82 A > G and 675 4G > 5G alleles of MMP 2 , MMP 3 , MMP 9 , MMP 12 and PAI 1 , respectively . ^^^ |
|
| Interacting proteins: P05121 and P08254 |
Pubmed |
SVM Score :0.0 |
| Enhanced invasion was not associated with significant changes in the expression of uPA or its membrane receptor UPAR ; plasminogen activator inhibitors PAI 1 and PAI 2 ; metalloproteinases MMP 1 , MMP 2 , MMP 3 , MMP 9 and membrane type MMP 1 ; or tissue inhibitors of metalloproteinases TIMP 1 and TIMP 2 . ^^^ |
|
| Interacting proteins: P05121 and P08254 |
Pubmed |
SVM Score :0.0 |
| Enhanced invasion is associated with increased u PA , UPAR , PAI 1 , MT MMP 1 , MMP 9 and TIMP 1 expression ; with reduced t PA , MMP 1 and MMP 3 expression ; and with the induction of membrane MMP 9 association . ^^^ |
|
| Interacting proteins: P05121 and P08254 |
Pubmed |
SVM Score :0.0 |
| As expected , steroid withdrawal reversed progestin inhibited PA activity as well as the expression of MMP 1 and MMP 3 and progestin enhanced PAI 1 ; much greater reversal was observed in medium supplemented with RU 486 . ^^^ |
|
| Interacting proteins: P05121 and P08254 |
Pubmed |
SVM Score :0.0 |
| Genetic analysis of MMP 3 , MMP 9 , and PAI 1 in Finnish patients with abdominal aortic or intracranial aneurysms . ^^^ MMP 3 , MMP 9 , and PAI 1 are present at increased levels in abdominal aortic aneurysms ( AAAs ) . ^^^ |
|
| Interacting proteins: P05121 and P08254 |
Pubmed |
SVM Score :0.0 |
| The Cyr 61 regulated genes fall into several groups known to participate in processes important for cutaneous wound healing , including : 1 ) angiogenesis and lymphogenesis ( VEGF A and VEGF C ) ; 2 ) inflammation ( interleukin 1beta ) ; 3 ) extracellular matrix remodeling ( MMP 1 , MMP 3 , TIMP 1 , uPA , and PAI 1 ) ; and 4 ) cell matrix interactions ( Col1alpha1 , Col1alpha2 , and integrins alpha ( 3 ) and alpha ( 5 ) ) . ^^^ |
|
| Interacting proteins: P05121 and P08254 |
Pubmed |
SVM Score :0.0 |
| The expression of tissue factor ( TF ) , the primary initiator of hemostasis ; urokinase type plasminogen activator ( uPA ) ; tissue type plasminogen activator ( tPA ) ; plasminogen activator inhibitor 1 ( PAI 1 ) as well as the potent matrix metalloprotease , MMP 3 was assessed . ^^^ It was observed , that RU 486 blocks and reverses progestin enhanced stromal cell TF protein and mRNA expression and PAI 1 protein and mRNA expression , whereas blocks and reverses progestin inhibited stromal cell uPA , tPA and MMP 3 protein and mRNA expression . ^^^ |
|
| Interacting proteins: P05121 and P08254 |
Pubmed |
SVM Score :0.0 |
| Furthermore , MMP 3 specifically hydrolyzes and inactivates human plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^ Stable PAI 1 bound to vitronectin is cleaved and inactivated by MMP 3 in a comparable manner as free PAI 1 ; the cleaved protein , however , does not bind to vitronectin . ^^^ Cleavage and inactivation of PAI 1 by MMP 3 may thus constitute a mechanism decreasing the antiproteolytic activity of PAI 1 and impairing the potential inhibitory effect of vitronectin bound PAI 1 on cell adhesion and / or migration . ^^^ |
|
| Interacting proteins: P05121 and P08254 |
Pubmed |
SVM Score :0.0 |
| After 48hr mRNA expression of MMP 1 , MMP 3 , TIMP 1 , uPA , tPA and PAI 1 was analyzed by RT PCR ELISA . ^^^ The protein synthesis of TIMP 1 and MMP 3 was determined by immunoprecipitation , PAI 1 protein was quantitated by ELISA . ^^^ |
|
| Interacting proteins: P05121 and P08254 |
Pubmed |
SVM Score :0.0 |
| The expression levels of MMP 1 , MMP 2 , MMP 14 , and TIMP 1 markedly exceeded the control levels at 1 . 0g / cm ( 2 ) of compressive force , whereas the expression levels of MMP 3 , MMP 13 , TIMP 2 , TIMP 3 , TIMP 4 , tPA , uPA , and PAI 1 markedly exceeded the control levels at 3 . 0g / cm ( 2 ) . ^^^ |
|
| Interacting proteins: P05121 and P08254 |
Pubmed |
SVM Score :0.0 |
| MAIN OUTCOME MEASURES : Fasting blood ( 50 ml ) was obtained , and the following parameters were assayed : high sensitivity CRP , fibrinogen , lipid profile , insulin , whole blood cytokines after stimulation with lipopolysaccharide ( LPS ; 100 ng / ml for 24 h ) , soluble cell adhesion molecules , plasminogen activator inhibitor 1 , CD 40 , CD 40 ligand , leptin , adiponectin , monocyte chemoattractant protein 1 , IL 8 , matrix metalloproteinase 3 ( MMP 3 ) , and MMP 9 . ^^^ |
|
| Interacting proteins: P05121 and P08254 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05121 and P08254 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05121 and P08254 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05121 and P08254 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05121 and P08254 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05121 and P08254 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05121 and P08254 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05121 and P08254 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05121 and P08254 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05121 and P08254 |
Pubmed |
SVM Score :0.0 |
| NA |
|