Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
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Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.57563575
Gel filtration experiments of mixtures of functionally active and inactive forms of plasminogen activator inhibitor ( PAI ) with human plasma or bovine serum albumin have provided evidence for the existence of a discrete binding protein of PAI in plasma . 0.57563575^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.64970569
Unglycosylated PAI 1 from E . coli exhibited characteristic properties of authentic PAI 1 : ( 1 ) it was recovered in both active and inactive ( latent ) forms ; ( 2 ) its activity declined during incubation at 37 degrees C ; ( 3 ) latent PAI 1 was activated by treatment with 4 M guanidine hydrochloride ; ( 4 ) reactivated PAI 1 formed a detergent stable complex with tissue plasminogen activator . 0.64970569^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.62235047
In contrast , the initial tPA / PAI 1 interaction can be competed only partially with plasminogen , suggesting that the tPA / PAI 1 interaction may involve a mixed type of inhibition . 0.62235047^^^ Steady state kinetic analysis of the effect of PAI 1 on the rate of plasminogen activation revealed that the initial UK / PAI 1 interaction can be competed with plasminogen suggesting that the UK / PAI 1 interaction may involve a competitive type of inhibition . 0.56870833^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.66480754
Two different techniques have been used to study the complex formation of recombinant human plasminogen activator inhibitor type 1 , PAI 1 , with either recombinant human two chain tissue plasminogen activator , tc tPA ( EC 3 . 4 . 21 . 68 ) , or the tPA deletion variants tc K2P , containing the kringle 2 domain and the proteinase domain , and P , containing only the proteinase domain . 0.66480754^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.62019993
ELISA for complexes of urokinase type and tissue type plasminogen activators with their type 1 inhibitor ( uPA PAI 1 and tPA PAI 1 ) . 0.62019993^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.52426084
Fibrinogen and von Willebrand factor , representatives of the hemostatic system , and plasminogen activator inhibitor 1 ( PAI 1 ) , as the most important inhibitor of the fibrinolytic system , have been associated with visceral obesity , with the most convincing evidence found for the involvement of PAI 1 . 0.52426084^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.85502951
This mutant UPA had similar plasminogen activator characteristics as wild type UPA , including its specific activity and interaction with plasminogen activator inhibitor 1 . 0.85502951^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.79182116
Insulin like growth factor binding protein 5 activates plasminogen by interaction with tissue plasminogen activator , independently of its ability to bind to plasminogen activator inhibitor 1 , insulin like growth factor 1 , or heparin . 0.79182116^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Endothelial plasminogen activator inhibitor ( PAI ) : a new member of the Serpin gene family . ^^^ A human endothelial cDNA expression library , based on the Escherichia coli plasmid pUC 9 , was screened with a heterologous antibody raised against purified bovine aortic endothelial plasminogen activator inhibitor ( PAI ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The mechanism by which activated protein C stimulates fibrinolysis was studied in a simple radiolabeled clot lysis assay system containing purified tissue type plasminogen activator , bovine endothelial plasminogen activator inhibitor ( PAI ) , plasminogen , 125I fibrinogen and thrombin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The primary target for endothelial plasminogen activator inhibitor ( PAI ) is located within the L chain of t PA . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
An enzyme linked immunosorbent assay ( ELISA ) used to study the cellular secretion of endothelial plasminogen activator inhibitor ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The hybrid molecules form a 1 : 1 molar complex with the human endothelial plasminogen activator inhibitor ( PAI 1 ) , analogous to that formed by rt PA and HMW u PA . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The predicted amino acid sequence of mPAI 2 is very similar to placental PAI 2 ( 3 amino acid differences ) and shows extensive homology with members of the serine protease inhibitor ( serpin ) superfamily . mPAI 2 was found to be more homologous to ovalbumin ( 37 % ) than the endothelial plasminogen activator inhibitor , PAI 1 ( 26 % ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
However , unlike the human endothelial plasminogen activator inhibitor , which also has a Met residue in the P 1 ' position , oxidation of the horse inhibitor only slightly reduces its association rate constant with either of the elastolytic enzymes tested or with chymotrypsin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
These included strong upregulation of interferon responsive genes such as interferon response factor 7 ( IRF 7 ) and myxovirus resistance protein R 1 , plus upregulation of exodus 2 beta chemokine , RDC 1 alpha chemokine receptor , and transforming growth factor beta 3 , together with strong downregulation of cell adhesion factors alpha ( 4 ) integrin and fibronectin plus downregulation of bone morphogenesis protein 4 , matrix metalloproteinase 2 , endothelial plasminogen activator inhibitor 1 , connective tissue growth factor , and interleukin 8 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Pharmacological modulation of the in vivo induction of plasminogen activator inhibitor type 1 ( PAI 1 ) synthesis was studied in rats using the induction of PAI 1 by endotoxin as a model system . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The regulation of plasminogen activators ( PA ) and their inhibitors ( PAI ) in the rat cell lines : HTC and L 2 was studied . ^^^ HTC plasminogen activator inhibitor type 1 ( PAI 1 ) production was stimulated by dexamethasone , serum factors and insulin ; that of tissue type plasminogen activator ( tPA ) by cAMP raising agents . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The plasminogen activator inhibitor ( PAI ) activity remained at baseline levels until 30 min , but rose fourfold at 90 min . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
These properties have been attributed to its profibrinolytic activity [ increase of tissue plasminogen activator ( t PA ) activity , concomitant decrease of that of plasminogen activator inhibitor ( PAI ) ] , but there could conceivably be other factor ( s ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The releases of tissue type plasminogen activator ( t PA ) , and epoprostenol ( Epo ) from endothelial cells were stimulated by NB , but no significant effect of plasminogen activator inhibitor ( PAI ) activity was seen . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The concentrations of tissue plasminogen activator ( t PA ) , urokinase plasminogen activator ( u PA ) and plasminogen activator inhibitor ( PAI 1 ) have been determined in endometrial curettings obtained from 46 subfertile women during proliferative , early or late secretory phases of the menstrual cycle . t PA activity and antigen concentrations was significantly higher ( P < 0 . 001 ) in late secretory endometrium than in proliferative or early secretory endometrium . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue plasminogen activator ( t PA ) , urokinase plasminogen activator ( u PA ) and plasminogen activator inhibitors ( PAI ) are elevated in late pregnancy with t PA and u PA remaining so at 6 weeks postnatal . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Gene expression of plasminogen activator inhibitor ( PAI ) types 1 and 2 is modulated by the protein kinase C ( PKC ) and cAMP dependent protein kinase A ( PKA ) signal transduction pathways . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibition ( PAI ) has also been demonstrated in plasma and outer acrosomal membranes of both species and identified as PAI 1 in membranes of human spermatozoa . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue plasminogen activator ( t PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) levels in plasma and peritoneal effluent in patients on CAPD . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The human hepatoma HuH 7 cell line was shown to constitutively express both a plasminogen activator ( PA ) and a plasminogen activator inhibitor ( PAI ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
These complexes were probably formed by activation of urokinase type plasminogen activator ( u PA ) , and not tissue type plasminogen activator ( t PA ) , since SF levels of both u PA antigen and u PA plasminogen activator inhibitor ( PAI ) complexes were increased in 27 of the 42 patients . ^^^ In some patients , activation of factor 12 presumably also contributed to plasminogen activation in SF , since levels of factor XIIa C 1 inhibitor in SF were increased in 8 of the 42 patients and correlated , as did u PA PAI levels , with levels of PAP complexes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the salivary samples the concentrations of tPA ( tissue type plasminogen activator ) , PAI 1 ( plasminogen activator inhibitor type 1 ) , albumin and total protein were determined and the activity of amylase , tPA and PAI assessed . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
However , in contrast to tPA , such treatment led to a 3 fold increase in plasminogen activator inhibitor ( PAI ) activity , whereas the amount of PAI type 1 antigen was unchanged . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Inhibition of HPMC fibrinolytic activity is due , in part , to elaboration of plasminogen activator inhibitors 1 and 2 ( PAI 1 and PAI 2 ) as well as antiplasmins . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We also measured plasminogen activator activity ( PA ) and urokinase inhibitory ( PAI ) activity in the spent culture media of macrophages recovered from the postsurgical peritoneal exudate . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In RA patients , extravascular t PA mediated plasminogen activation was depressed : mean SF tissue type plasminogen activator ( t PA : Ag ) concentration ( 2 . 1 + / 1 . 6 ng / ml ) was four fold lower , and plasminogen activator inhibitor ( PAI ) activity ( 284 + / 212 % ) four fold higher than the plasma values of the same patients or of healthy donors . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Increased levels of tissue plasminogen activator ( t PA ) and tissue plasminogen activator inhibitor ( PAI ) correlate with tumor necrosis factor alpha ( TNF alpha ) release in patients suffering from microangiopathy following allogeneic bone marrow transplantation ( BMT ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In dose and time course studies , HLF plasminogen activator inhibitor 1 ( PAI 1 ) was increased by TGF beta , whereas TNF alpha induced release of PAI 1 into the media . ^^^ These studies suggest that TGF beta and TNF alpha impair the ability of HLF to degrade fibrin by disturbing the balance of HLF plasminogen activators and PAI and that these cytokines concurrently leave unchanged or increase the capacity of HLF to initiate fibrin formation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue type plasminogen activator antigen ( t PA : Ag ) , urokinase type plasminogen activator antigen ( u PA : Ag ) , the proenzyme single chain u PA ( scu PA ) , and plasminogen activator inhibitor ( PAI ) were measured in the synovial fluid and plasma of 22 patients with seropositive rheumatoid arthritis ( RA ) , 13 with seronegative RA , and 23 patients with various forms of arthritis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Data from a number of laboratories indicate that human platelets contain type 1 plasminogen activator inhibitor ( PAI 1 ) primarily in a latent form ; however , one report ( Biochemistry 28 : 5773 , 1989 ) indicated that it is predominantly the active form of PAI 1 that is present in and can be purified from an ammonium sulfate precipitate of porcine platelets . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor ( PAI ) activity , an important regulator within the fibrinolytic system , has been shown to be a risk indicator for venous and arterial thrombosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To evaluate the suggested imbalance between coagulation and fibrinolysis in the development of glomerulonephritis , plasminogen activator inhibitor ( PAI ) activity was studied in the plasma of rats with nephrotoxic nephritis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue plasminogen activator inhibitor ( PAI ) increased in a cyclic way reaching peak values 4 6 weeks after the start of investigation and again 4 6 weeks after changing therapy . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Retinal pigment epithelial cells secrete urokinase type plasminogen activator and its inhibitor PAI 1 . ^^^ The results showed that these cells produce urokinase type plasminogen activator ( u PA ) and a plasminogen activator inhibitor ( PAI ) which is immunologically and biochemically similar to PAI 1 . ^^^ We conclude that RPE cells have the potential to utilize u PA catalyzed plasminogen activation which is subject to regulation by PAI 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In order to study the effects of chronic venous hypertension due to heart failure on blood fibrinolytic activity , tissue plasminogen activator ( t PA ) antigen , plasminogen activator inhibitor 1 ( PAI 1 ) antigen , t PA activity and PAI activity were measured before and after venous occlusion of the arm for 20 min in 15 patients with right sided heart failure , 15 patients with left sided heart failure , and 30 control healthy subjects . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This was associated with higher inhibition of plasminogen activator activity ( PAI ) in the AA than IVC , 1 . 75 IU / ml , p = 0 . 002 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The plasminogen activator inhibitor ( PAI ) activity in the whole group did not change significantly ( 6 . 4 + / 4 . 1 to 5 . 4 + / 4 . 8 AU / ml ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This information suggests that a high concentration of t PA may be released into the narrow channels of the glands functioning to maintain duct patency under the regulation of an inhibitor such as plasminogen activator inhibitor ( PAI ) . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We describe studies on variation in the genes coding for factor 7 ( FVII ) and plasminogen activator inhibitor 1 ( PAI 1 ) that influence levels of these proteins in the blood . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Thrombin antithrombin 3 complex ( TAT ) and plasminogen activator inhibitor ( PAI ) were measured during liver resection surgery in 8 patients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The former group was examined 14 to 20 years after surgery , and was found to have lower mean plasminogen activator inhibitor type 1 ( PAI 1 ) activity ( 8 . 4 5 32 U / mL , P < . 001 ) , tissue plasminogen activator ( tPA ) antigen concentrations ( 7 . 2 5 12 micrograms / L , P < . 01 ) , body mass index ( BMI ) , and fasting plasma insulin , triglyceride , and cholesterol levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The latter was associated with elevated FXII and PKK , while C 1 INH was decreased , ATIII and alpha 2M were unchanged ; it could not be accounted for by changes in t PA , u PA , PAI , plasminogen , alpha 2 AP , proteins C or S . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In this study , we tried to elucidate the mechanism of coagulation fibrinolysis with relation to kks by measuring of Thrombin / Antithrombin 3 complex ( TAT ) , tissue plasminogen activator ( tPA ) , plasminogen activator inhibitor 1 ( PAI ) complex ( tPA . ^^^ C ) , active plasminogen activator inhibitor 1 ( active PAI ) , alpha 2 plasmin inhibitor / plasmin complex ( PIC ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This systemic information was evaluated in 20 cases of normal gravidas from 28 to 42 weeks of gestation as a control by measuring plasma Thrombin / Antithrombin 3 complex ( TAT ) , tissue plasminogen activator ( tPA ) plasminogen activator inhibitor ( PAI ) complex , active plasminogen inhibitor 1 ( active PAI ) , 2PI plasmin complex ( PIC ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The coronary patients had significantly higher plasminogen activator inhibitor ( PAI ) activity than the control subjects , while t PA antigen did not differ between the groups . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To study the plasminogen activator inhibitor ( s ) ( PAI ) produced in vitro by human synovial fibroblast like cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasmin generation from plasminogen is regulated by plasminogen activator ( s ) ( PA ) and plasminogen activator inhibitor ( s ) ( PAI ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We found an increase of plasminogen activator inhibitor ( PAI , P < 0 . 001 ) and a decrease of free protein S ( PSf , P < 0 . 001 ) and total protein S ( PSt , 0 . 01 < P < 0 . 05 ) in the patients with LA when compared with the control group . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The mean levels of plasminogen , tissue plasminogen activator ( t PA ) antigen and plasminogen activator inhibitor ( PAI ) activity were significantly higher than in normal subjects , whereas the basal fibrinolytic activity was similar to that seen in the control group . ^^^ In conclusion , the impaired fibrinolytic activation seen in Cushing patients after venous occlusion can be explained by the inhibitory effect of the high PAI levels on plasminogen activators . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen , plasminogen activators ( PA ) , tissue type plasminogen activator ( t PA ) , urokinase type plasminogen activator ( u PA ) , alpha 2 antiplasmin ( alpha 2 AP ) , plasminogen activator inhibitor ( PAI ) , fibrinogen / fibrin degradation products ( FDP ) and D dimer were determined to elucidate the role of plasminogen activators and inhibitors in the pathogenesis of accelerated fibrinolysis in schistosomiasis . ^^^ In addition , there was progressive decrease of plasminogen , alpha 2 AP and PAI levels which might be due to decreased hepatic synthesis and / or increased peripheral consumption . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
On the first and seventh administration days , the following parameters were evaluated : plasminogen activator inhibitor ( PAI 1 ) activity , PAI 1 antigen , tissue plasminogen activator ( t PA ) and whole blood , serum and plasma viscosity , before ( 0 time ) and 2 , 4 and 8 hours after ingestion of the drug . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue plasminogen activator ( tPA ) activity , plasminogen activator inhibitor ( PAI ) activity , von Willebrand ' s factor ( vWF ) activity and antigen ( vWF : Ag ) , and factor 8 activity were measured . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Both treatments induced a transient phase of increased blood fibrinolytic activity , as evidenced by higher levels of tissue type plasminogen activator ( t PA ) activity and decreased levels of PA inhibitor ( PAI ) activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Vital signs , EKG tracings and laboratory parameters were monitored before and after the angiographic procedure ; the coagulation screening included : thrombin time , prothrombin time , partial thromboplastin time , euglobulin lysis time , plasma thromboplastin antecedent , and plasminogen activator inhibitor ( PAI ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue plasminogen activator ( t PA ) activity , plasminogen activator inhibitor 1 ( PAI 1 ) activity , plasminogen , alpha 1 proteinase inhibitor ( alpha 1 PI ) , alpha 2 antiplasmin ( alpha 2 AP ) , antithrombin 3 ( AT 3 ) , fibrinogen , and ELT were measured 0 . 5 , 1 , 3 , and 6 h after the induction of taurocholate AEP in rats , as well as in sham operated animals and the control group , which was not submitted to any operation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Measurements of euglobulin clot lysis time ( ELT ) , fibrinogen , antithrombin 3 ( AT 3 ) , protein C ( PC ) , protein S ( PS ) , tissue plasminogen activator ( tPA ) , and plasminogen activator inhibitor ( PAI ) were done . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue plasminogen activator ( t PA ) antigen ( Ag ) and activity and tissue plasminogen activator inhibitor ( PAI ) were measured before and after DDAVP . t PA Ag was found to be significantly higher before DDAVP in patients than in controls . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We analyzed the fibrinolytic system in patients with chronic low back pain using a venous occlusion test to stimulate fibrinolysis , and we subsequently determined the levels of tissue plasminogen activator ( TPA ) and fast acting inhibitor of TPA ( PAI ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We observed no significant differences between diets in terms of fasting plasma levels of factor 7 coagulant activity , fibrinogen , euglobulin fibrinolytic activity , tissue type plasminogen activator ( t PA ) activity , t PA antigen , plasminogen activator inhibitor type 1 ( PAI 1 ) antigen , or PAI activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The effect of therapeutic and pharmacological concentrations of tiaprofenic acid , a non steroidal anti inflammatory drug ( NSAID ) , on the synthesis of the plasminogen activators , urokinase plasminogen activator ( uPA ) and tissue plasminogen activator ( tPA ) , and the plasminogen activator inhibitors 1 and 2 ( PAI 1 and PAI 2 ) , by human synovial membranes isolated from osteoarthritis ( OA ) and rheumatoid arthritis ( RA ) sufferers was evaluated . ^^^ Both forms of plasminogen activator ( PA ) and PA inhibitor ( PAI ) were synthesized by the arthritic synovium . ^^^ PAI 1 and PAI 2 were both synthesized in greater amounts than the plasminogen activators . ^^^ The suppressive action of tiaprofenic acid on PAI is not likely to have a significant impact on the balance of plasminogen activators and plasminogen activator inhibitors , as plasminogen activator inhibitors are synthesized in greater amounts than plasminogen activators . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The following parameters were measured : total cholesterol ( Chol ) , triglycerides ( TG ) , HDL cholesterol ( HDL C ) , LDL cholesterol ( LDL C ) , apoprotein A 1 ( apoA 1 ) , apoprotein B ( apoB ) , lipoprotein ( a ) or Lp ( a ) , fibrinogen , insulinemia and plasminogen activator inhibitor activity ( PAI ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Among obese insulin resistant subjects plasminogen activator inhibitor 1 ( PAI 1 ) levels are closely associated with fasting insulin levels in cross sectional as well as intervention studies . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Platelet associated epidermal growth factor ( EGF ) and transforming growth factor beta ( TGF beta ) can augment synthesis of plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The plasma levels of tissue plasminogen activator ( tPA ) antigen concentration and plasminogen activator inhibitor ( PAI ) activity were measured in a random sample of 260 subjects , 30 , 40 , 50 , or 60 years of age . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue plasminogen activator ( t PA ) antigen and activity , plasminogen activator inhibitor ( PAI ) antigen and activity , thrombin antithrombin 3 ( TAT ) complexes were determined in blood samples . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The fibrinolytic capacity of the blood mainly depends on the amount of tissue plasminogen activator ( t PA ) antigen and plasminogen activator inhibitor ( PAI ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The aim of this study is to evaluate the relationship between tissue plasminogen activator ( tPA ) / PA inhibitor ( PAI ) complex and PAI , and platelet in the circulating blood . tPA / PAI complex and active PAI ( act PAI ; Teijin Co . , Japan ) , and PAI antigen ( PAI ant ; Biopool AB , Sweden ) were assayed by enzyme immunoassay ( EIA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Endothelial cell products , plasminogen activator inhibitor ( PAI ) and von Willebrand factor ( vWF ) , were assayed in 25 patients with newly diagnosed and untreated polymyalgia rheumatica ( PMR ) , before and after three and 12 months of corticosteroid treatment . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In order to find out which hemostasis parameters would have the predictive value for the development of preeclampsia , modified antithrombin 3 ( ATM , representative of the antithrombin 3 serine esterase complex ) , tissue plasminogen activator ( tPA ) , plasminogen activator inhibitor 1 ( PAI 1 ) , beta thromboglobulin ( BTG ) , antithrombin 3 ( AT 3 ) , fibrinogen , fibrin ( ogen ) degradation product ( FDP ) , FDP D dimer and euglobulin lysis time ( ELT ) were measured in 20 normal non pregnant women , 21 normal pregnant women , 6 high risk pregnant women , 14 preeclampsia pregnant women , and 5 patients with disseminated intravascular coagulation ( DIC ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The cause must be searched in the observed increase of plasminogen activator inhibitor ( PAI ) likly in combination with a decrease of the tissue type plasminogen activator ( t PA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To examine the fibrinolytic capacity in patients with acute myocardial infarction ( AMI ) , baseline levels of plasma plasminogen activator inhibitor ( PAI ) activity and tissue type plasminogen activator ( t PA ) antigen were measured in 47 patients with Q wave AMI who underwent emergent coronary angiography 3 . 0 + / 0 . 2 hours after the symptom onset . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Although both plasminogen activators ( PA ) and their inhibitors ( PAI ) contribute to this process , their regulation in normal and transformed cells remains poorly defined . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Admission hemostatic markers that correlated with the severity of injury were : tissue plasminogen activator ( tPA ) , plasminogen activator inhibitor ( PAI ) , D dimer ( D di ) , plasminogen ( Plg ) , proteins C and S ( PrC and PrS ) , antithrombin 3 ( ATIII ) , thrombin antithrombin complex ( TAT ) , kallikrein ( Kal : c ) , kinin ( Kin ) , C 1 esterase inhibitor ( C1Inh ) , and factor 7 clotting and antigen ( FVII : c , FVII : ag ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor ( PAI ) activity and tissue plasminogen activator ( TPA ) antigen were measured in venous samples in 14 patients with unstable angina consisting of eight patients with organic stenosed coronary arteries and six patients with coronary spastic angina ( unstable angina group ) ; in 14 patients with stable exertional angina ( stable exertional angina group ) ; and in 14 patients with chest pain syndrome ( chest pain syndrome group ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Levels of complement C3a and C3d significantly correlated with levels of plasminogen activator inhibitor 1 ( PAI ) and correlated inversely with AT 3 levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A plasminogen activator inhibitor ( PAI ) activity with molecular sizes of 54 and 58 kDa was also detected in PC 12 cell conditioned medium and formed high molecular mass complexes with released tPA . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have previously reported that normal pleural leukocytes secrete a urokinase type plasminogen activator inhibitor ( PAI ) in culture . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The conditioned media from postsurgical Day 1 macrophage culture strongly inhibited urokinase type plasminogen activator ( PA ) and this plasminogen activator inhibitor ( PAI ) activities decreased following the extension of postsurgical time . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue plasminogen activator in blood was also significantly increased on day 1 , but it was decreased thereafter , although plasminogen activator inhibitor ( PAI ) remained high for at least 7 days after TAE . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The changes of fibrinolytic activity suggest that t PA , PL and FDP were increased , while PAI , PLG , and alpha PI were decreased . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Therefore , we looked for alterations of fibrinolytic parameters ( tissue plasminogen activator ( t PA ) , tissue plasminogen activator inhibitor ( PAI ) , D dimer , euglobulin clot lysis time ( ECLT ) , plasminogen , alpha 2 antiplasmin ) and of some coagulation parameters ( prothrombin time , fibrinogen , platelets , antithrombin 3 , protein C , factor 12 ) in clearly defined septic patients and for the relations of these values to the severity of the disease ( APACHE 2 score ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We used the amnion invasion assay to investigate whether monocyte invasiveness is affected by matrix bound plasminogen activator inhibitors ( PAI ) and by fluid phase u PA . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Several investigators have reported that tumor necrosis factor ( TNF ) can alter the production of plasminogen activator type 1 ( PAI 1 ) and plasminogen activators ( PAs ) by endothelial cells in vitro . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We found significantly higher levels of thrombin antithrombin 3 ( TAT ) complexes , lower levels of systemic tissue plasminogen activator ( t PA ) activity , and higher levels of plasminogen activator inhibitor ( PAI ) activity in the AMI patients compared to the UAP patients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The authors examined the effect of insulin like growth factor 1 ( IGF 1 ) , epidermal growth factor ( EGF ) , and acidic fibroblast growth factor ( AFGF ) on the synthesis by human retinal endothelial cell ( HREC ) of plasminogen activators ( PA ; tissue type [ t PA ] and urokinase type [ u PA ] ) and plasminogen activator inhibitor ( PAI ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the patients with SLE both tissue plasminogen activator antigen and plasminogen activator inhibitor ( PAI ) were increased , but these changes were not due to APA which had no effect on fibrinolysis in these patients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In 6 patients undergoing programmed ventricular stimulation with repeated induction of clinical ventricular tachycardia , the coronary release of tissue type plasminogen activator ( t PA ) antigen , plasminogen activator inhibitor ( PAI ) capacity , von Willebrand factor antigen ( WF : Ag ) , and prostacyclin ( 6 keto PGF 1a ) was measured . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The following parameters were measured in the haemothorax liquid samples : clotting fibrinogen fraction ( Fg C ) , fibrin degradation D dimers , functional plasminogen , alpha 2 antiplasmin , alpha 2 macroglobulin , plasminogen tissue activator ( tPA Ag ) , type 1 tPA plasma inhibitor ( PAI ) , and haematocrit . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Alpha 2 antiplasmin , plasminogen activator inhibitor ( PAI ) and dilute blood clot lysis time in selected disease states . ^^^ When compared to 20 control subjects the 30 hypertriglyceridemic patients ( 14 with type IIb and 16 with type 4 ) displayed significantly ( p less than 0 . 001 ) increased plasma plasminogen activator inhibitor ( PAI ) activity ( 221 + / 88 % and 290 + / 104 % respectively ; mean + / SD ) , moderately ( p less than 0 . 01 ) increased alpha 2 antiplasmin ( alpha 2AP ) level ( 112 + / 11 % and 115 + / 16 % ) and accordingly an obviously prolonged dilute blood clot lysis time ( DBCLT ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
An impaired release of tPA and / or increased plasminogen activator inhibitor ( PAI ) is associated with thrombotic risk in the adult patient . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Phorbol myristate acetate ( PMA ) added to human synovial fibroblast cultures caused a dose dependent increase in the production of plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^ In addition , PMA inhibited endogenous and interleukin 1 ( IL 1 ) induced plasminogen activator ( PA ) activity , while increasing mRNA PAI 1 levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The apparent difference in u PA activity and antigen levels of these two lines was not due to the difference in the production of plasminogen activator inhibitor ( PAI ) , because PAI antigen level and PAI activity in the culture media were almost equal between them . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
PL 21 is a promyelocytic leukemia cell line that produces plasminogen activator inhibitor 2 ( PAI 2 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
At the same time ( 4th 7th day ) the plasminogen activator activity ( PAA ) in seminal plasma was found to be increased , but the plasminogen activator inhibition ( PAI ) expressed against t PA ( anti t PA ) showed an increase between 32nd and 46th day . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We investigated 148 diabetic patients with regard to their relationship between fibrinolysis ( D dimer and plasminogen activator inhibitor ; PAI ) and glycometabolic control ( HbA1c , HbA 1 and fructosamine ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activators t PA , u PA and its inhibitor ( PAI ) in normal males and females . ^^^ We determined the plasma levels of tissue plasminogen activator ( t PA ) , plasminogen activator inhibitor ( PAI ) activity and their antigen levels including urokinase plasminogen activator ( u PA ) in 33 male and 27 female normal subjects . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator activity ( PAA ) , plasminogen activator inhibition ( PAI ) and plasmin inhibition ( PI ) have been studied with spectrophotometric methods in extracts of human , bovine , ovine and rat kidneys of both sexes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Coagulation studies indicated that both patients acquired high levels of tissue type plasminogen activator inhibitor ( PAI ) with deficiency in tissue type plasminogen activator ( t PA ) and consequent impaired fibrinolysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
ELT measures plasminogen activator activity ( PAA ) while FA which is a more global test measures the net effect of the PAA , the plasminogen activator inhibitor ( PAI ) and the clot structure . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Inhibitor of tissue plasminogen activator ( PAI ) and ischemic cardiopathy ] . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Dynamic change of serum tissue type plasminogen , activator ( t PA ) and PAI activity was studied in 22 cases with acute myocardial infarction ( AMI ) 11 cases with unstable angina ( UA ) and 24 healthy persons . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We studied the diurnal variation in tissue type plasminogen activator ( t PA ) and plasminogen activator inhibitor ( PAI ) antigens and activities during a 24 h period . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the normal stomach of male rats marked differences in plasminogen activator activity ( PAA ) and plasmin inhibition ( PI ) , but not in plasminogen activator inhibition ( PAI ) , were noted among cardiac area , body and pyloric region . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Analysis of enzymatic activity indicates that under conditions where syn uPA and std uPA are completely inhibited by endothelial type plasminogen activator inhibitor ( PAI 1 ) , mut uPA retains 90 % activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A complete fibrinolytic profile including total fibrinolytic activity ( TFA ) , tissue plasminogen activator ( t PA ) , plasmin inhibitor ( PI ) , plasminogen activator inhibitor ( PAI ) , protein C ( PC ) and plasminogen ( PLG ) was obtained preoperatively in 114 brain tumor patients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To investigate short term activation and inhibition of fibrinolysis during shock , we studied plasma levels of tissue type plasminogen activator ( t PA ) and t PA inhibition capacity ( PAI ) in anaesthetized pigs . t PA in euglobulin fractions of plasma was measured by the conversion of plasminogen to plasmin in the presence of fibrin split products . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In all patients there was significant elevation of ATIII , PC , PS , and plasminogen , reduction in plasma fibrinogen and PAI and enhancement of fibrinolysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The effect of unilateral and bilateral adrenalectomy , unilateral and bilateral demedullation or unilateral adrenalectomy / unilateral demedullation on tissue plasminogen activator activity ( PAA ) , plasminogen activator inhibition ( PAI ) and plasmin inhibition ( PI ) was studied in the rat . ^^^ A decreased PAI expressed against tissue type plasminogen activator ( t PA ) and urokinase type plasminogen activator ( u PA ) was found in lungs of all treated rats compared to controls . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Differentiation linked expression of plasminogen activator inhibitor 2 ( PAI 2 ) was investigated by adding cell differentiation promoting agents [ such as phorbol myristate acetate ( PMA ) , retinoic acid , dexamethasone ( Dex ) , and recombinant cytokines , including tumor necrosis factor alpha ( TNF alpha ) , transforming growth factor beta , granulocyte colony stimulating factor , and interleukin 6 ( IL 6 ) ] into the culture medium of a promyelocytic leukemia cell line PL 21 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The endothelial cell synthesized haemostatic factors tissue plasminogen activator ( tPA ) , plasminogen activator inhibitor ( PAI ) and von Willebrand factor ( vWF ) were assayed in a cross sectional study of patients with immune thrombocytopenia ( ITP ) ( n = 12 ) and autoimmune haemolytic anaemia ( AIHA ) ( n = 3 ) , and compared with a simultaneously selected contrast group of other hospitalized patients with obscure blood cytopenia at the time of sampling . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Two major plasminogen activator inhibitors ( PAI 1 and PAI 2 ) increase in the peripheral circulation during pregnancy in humans . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue type plasminogen activator ( t PA ) activity and antigen increased significantly in normal subjects , while plasminogen activator inhibitor ( PAI ) activity decreased . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue plasminogen activator ( t PA ) and its inhibitor ( PAI ) were assessed in venous blood drawn before and after venous occlusion ( bvo , avo ) for 33 patients with Raynaud ' s phenomenon ( RP ) , 14 with primary RP ( PRP ) , 9 with suspected secondary RP ( SSRP ) , and 10 with definite collagen disease and secondary RP ( SRP ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma tissue type plasminogen activator ( tPA ) , plasminogen activator inhibitor ( PAI ) and euglobulin lysis time ( ELT ) were determined before and after the venous occlusion test ( VOT ) in 3 groups of patients with mean age about 60 years : 29 diabetic patients ( D group ) , 8 hyperlipidemic patients ( H group ) and 19 healthy controls ( C group ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Disturbances in the tissue plasminogen activator / plasminogen activator inhibitor ( TPA / PAI ) system in systemic lupus erythematosus . ^^^ Despite the fact that the euglobulin lysis time in steady state was normal in all instances , disturbances in the tissue plasminogen activator / plasminogen activator inhibitor ( TPA / PAI ) system were found in all SLE patients : TPA activity was undetectable in all cases , whereas it was above 0 . 4 IU / ml in a control group . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Baseline plasminogen activator inhibitor ( PAI ) levels were examined for their influence on the responses to thrombolysis with recombinant tissue plasminogen activator ( rt PA ) administered for acute myocardial infarction during the Thrombolysis and Myocardial Infarction ( TAMI ) 1 study . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Urokinase type plasminogen activator ( u PA ) antigen , tissue type plasminogen activator ( t PA ) antigen and activity , plasminogen activator inhibitor ( PAI ) type 1 antigen , PAI activity , antithrombin ( AT ) 3 activity , and protein C activity were measured in 24 patients suffering from sepsis or septic shock and the results were compared with those observed in 30 non sepsis patients with severe infectious disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This process is associated with the increased expression of type 1 plasminogen activator inhibitor ( PAI 1 ) mRNA , and the secreted inhibitor is immobilized to the pericellular area . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) , the specific , fast acting inhibitor of tissue type plasminogen activator ( t PA ) , binds to fibrin and has been found in high concentrations within arterial thrombi . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We present here some data on antigen increase in tissue Plasminogen Activator ( tPA ) and D 2 Dimer ( D2D ) detected during CPB and apparently not compensated by enhanced Plasminogen Activator Inhibitor type 1 ( PAI 1 ) activity . tPA concentration ( antigenic ) ranged around 6 . 15 ng / ml ( SD 5 . 6 ) before thoracotomy and 5 . 8 g / ml ( SD 4 . 74 ) 5 10 minutes after a heparin 250 IU / Kg bolus injection . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Molecular forms of plasminogen activator inhibitor 1 ( PAI 1 ) and tissue type plasminogen activator ( t PA ) in human plasma . ^^^ Molecular forms of plasminogen activator inhibitor 1 ( PAI 1 ) and tissue type plasminogen activator ( t PA ) , identified by gel filtration and specific immunoassays , were studied in plasma from subjects with normal and elevated PAI 1 levels before and after in vitro or in vivo addition of t PA . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In Type 1 diabetic patients , after 2 3 months of treatment with gliclazide , we observed a significant increase in plasma concentrations of total t PA antigen that remained stable until discontinuation of the drug ( p less than 0 . 0002 ) , whereas the plasma concentrations of plasminogen activator inhibitor ( PAI ) did not change significantly during the study . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The levels of tissue type plasminogen activator ( t PA ) , plasminogen activator inhibitor ( PAI ) and other substances of coagulation fibrinolysis , such as fibronectin ( Fn ) and von willebrand factor ( vWF ) as well as the activity content of antithrombin 3 ( AT 3 ) in plasma were determined in 20 patients with acute myocardial infarction ( AMI ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Basal values of plasma tissue plasminogen activator ( t PA ) activity and antigen and of t PA inhibitor ( PAI ) were normally distributed in this patient group . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Thrombotic events are often due to fibrinolytic defects such as impaired tissue plasminogen activator ( tPA ) synthesis and / or release or increased plasminogen activator inhibitor ( PAI ) levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The release of plasminogen activators ( PAs ) and plasminogen activator inhibitor ( PAI ) from cultured bovine lens epithelial cells was investigated , in an attempt to study the effect of lens epithelial cells on the fibrin deposit and fibrinolytic process on the surface of IOL . ^^^ Cultured bovine lens epithelial cells released tissue plasminogen activator ( t PA ) and type 1 plasminogen activator inhibitor ( PAI 1 ) . t PA activity was completely inhibited by PAI 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The effects of both clot bound and circulating plasminogen activator inhibitor 1 ( PAI 1 ) on endogenous fibrinolysis were investigated in a rat model of pulmonary embolism . ^^^ Plasma levels of plasminogen activator ( PA ) and PAI activity were unaltered by administration of PAI 1 containing clots , and the clot protective effects of clot bound PAI 1 were reversed by exogenous tissue type plasminogen activator administration . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The following were measured on each sample : plasma factor 8 von Willebrand factor antigen ( FVIII vWF Ag ) , tissue plasminogen activator activity ( tPA ) , plasminogen activator inhibitor ( PAI ) , prostacyclin stimulating factor ( PGI 2 SF ) , fibrinopeptide A ( FPA ) , 11 dehydro thromboxane B 2 ( 11 dehydro TXB 2 ) and red cell deformability ( RCD ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This study was undertaken to investigate whether beta blockade alters the circadian rhythm of 2 major fibrinolytic factors , tissue plasminogen activator ( t PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Familial clustering of defective release of t PA . 91 unrelated patients with idiopathic or familial deep vein thrombosis ( DVT ) and 72 ( 34 with DVT ) relatives from 26 families were screened for hypofibrinolysis by measuring tissue plasminogen activator antigen ( t PA : Ag ) after venous occlusion ( VO ) for 10 and 20 min and by measuring t PA inhibitor activity ( PAI ) at rest . 21 healthy subjects served as controls . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Differentiation was accompanied by the expression and secretion of a plasminogen activator inhibitor ( PAI ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Thus plasminogen activator inhibitors ( PAI ) which bind the serine proteases responsible for the conversion of plasminogen to plasmin , may inhibit IL 1 release from Mo . ^^^ These properties conformed to characteristics of type 1 plasminogen activator inhibitor ( PAI 1 ) . ^^^ Partially purified PAI 1 added to human Mo cultured on 125I fibrin layer both in the presence and absence of plasminogen inhibited secretion of IL 1 by Mo in response to LPS . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Bovine vascular smooth muscle cells ( SMC ) were examined for production of plasminogen activator inhibitor 1 ( PAI 1 ) which may play a key role in regulating the fibrinolytic system . ^^^ The levels of PAI were significant since 880 AU of PAI could inhibit approximately 1 microgram of tissue plasminogen activator . ^^^ SMC PAI was a rapid inhibitor of tissue plasminogen activator ( kass greater than 10 ( 7 ) M 1 S 1 ) and was identified as a 45 kDa protein immunologically related to endothelial cell PAI 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor ( PAI ) is an important inhibitor of fibrinolysis in humans , and we have found basal activities of PA inhibition to be elevated in patients with diabetes compared with a reference group of healthy subjects ( mean + / SD 268 + / 268 vs . 105 + / 48 % ; P less than . 0001 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The persistency of fibrin deposits in the kidney during renal diseases could reflect either a defective release of plasminogen activators ( PA ) or a local excess of PAI . ^^^ In order to investigate this question , we studied human renal biopsies by immunofluorescence technique with specific antibodies for fibrin , tissue type plasminogen activator ( t PA ) , urokinase ( u PA ) , PAI 1 and PAI 2 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The amount of antigen of the two fibrinolytic factors , tissue type plasminogen activator ( t PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) , was determined using ELISA and the ABC method , respectively . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue plasminogen activator ( tPA ) antigen levels and plasminogen activator inhibitor ( PAI ) activity were measured in the plasma from 23 patients with familial amyloidotic polyneuropathy . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The effect of IGF 1 on the secretion of plasminogen activators was assessed using an immunological assay for tissue type plasminogen activator ( t PA ) and plasminogen activator inhibitor ( PAI ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The effects of thrombin , interleukin 1 ( IL 1 ) , tumor necrosis factor ( TNF ) and gamma interferon ( gamma IFN ) on the release of plasminogen activator ( PA ) and inhibitor ( PAI ) were studied using cultivated human glomerular epithelial cells ( GECs ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor ( PAI ) levels in patients with polycythemia vera and healthy volunteers did not differ significantly . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Changes in plasminogen activator ( PA ) and PA inhibitor ( PAI ) activities were measured during follicular development in granulosa cells ( GC ) and theca tissue ( TT ) isolated from the six largest yolk filled preovulatory follicles ( F 1 , F 2 , F 3 , F 4 , F 5 , F 6 ) and large white follicles ( LWF ) of the domestic hen . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor ( PAI ) was not detectable immediately after the race and was significantly decreased 3 h ( P less than 0 . 05 ) and 31 h ( P less than 0 . 01 ) later . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The tissue specific distribution of tissue type and urokinase type plasminogen activator ( t PA and u PA ) and their inhibitor type 1 ( PAI 1 ) was analyzed at mRNA level in five major rat organ tissues . t PA mRNA was detected in lung , kidney , heart , and liver . u PA mRNA was detected in kidney and lung . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Euglobulin clot lysis time , fibrin plate , tissue plasminogen activator ( t PA ) antigen , plasminogen activator inhibitor ( PAI ) activity , Protein C and S , cholesterol , triglycerides and Hb A1c were determined in blood samples . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Increased plasma levels of plasminogen activator inhibitor 1 ( PAI 1 ) have been shown to exist in 40 to 60 % of patients with stable coronary artery disease and have been suggested to be responsible for the development of coronary thrombotic complications . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Short term effects of moderate alcohol consumption on platelet function , tissue type plasminogen activator ( t PA ) and plasminogen activator inhibitor ( PAI ) were studied in two age groups of volunteers ( 20 30 and 45 55 years ) , each consisting of eight healthy males . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We measured plasminogen activators inhibitor ( PAI ) activity , C peptide levels , plasma fibrinolytic activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma levels of tissue plasminogen activator ( tPA ) antigen , tPA activity and plasminogen activator inhibitor ( PAI ) activity were determined in 40 cases of acute myocardial infarction ( AMI ) at the onset and 2 4 weeks after the onset of the disease . 24 healthy subjects served as controls . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma levels of tissue plasminogen activator ( t PA ) and plasminogen activator inhibitor ( PAI ) and the in vitro ability of platelets to aggregate and of monocytes to express procoagulant ( tissue factor ) activity ( PCA ) were evaluated in five patients who are homozygous for familial hypercholesterolemia ( FH ) before and after a single and a regular 5 month cholesterol removal by low density lipoprotein ( LDL ) apheresis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue type plasminogen activator ( t PA ) , plasminogen activator inhibitor ( PAI ) and fibrinopeptide A ( FPA ) levels were measured in the great cardiac venous and arterial blood of 9 patients with clinically and angiographically proven vasospastic angina and 11 controls . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor activity ( PAI ) , PAI 1 and PAI 2 antigen , and other fibrinolytic parameters were evaluated in amniotic fluid during normal pregnancy and compared with that obtained in plasma of pregnant women . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The cytokines tumor necrosis factor ( TNF ) , lymphotoxin , and interleukin 1 ( IL 1 ) , but not interleukin 6 , increase the production of plasminogen activator inhibitor 1 ( PAI 1 ) by endothelial cells , whereas they have no stimulatory effect on the production of tissue type plasminogen activator ( t PA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In addition , immuno cross reactive plasminogen activator inhibitor type 1 ( PAI type 1 ) and type 2 ( PAI type 2 ) were identified in cell free conditioned medium produced by both tumor cells and normal epidermal cells , using a micro ELISA assay . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Beta thromboglobulin ( BTG ) , platelet factor 4 ( PF 4 ) , fibrinopeptide A , tissue plasminogen activator ( t PA ) activity and antigen , tissue plasminogen activator inhibitor ( PAI ) , fibrin , and fibrinogen degradation products were studied during dialysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The transplacental effect of lead compounds ( lead acetate and tetraethyl lead ) on the tissue plasminogen activator activity ( PAA ) , plasminogen activator inhibition ( PAI ) and plasmin inhibition ( PI ) was studied in the rat . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Independent from risk factors PAD and CAD patients had elevated plasma plasminogen activator inhibitor capacity ( PAI cap ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The effect of unilateral or bilateral orchidectomy on tissue plasminogen activator activity ( PAA ) , plasminogen activator inhibition ( PAI ) and plasmin inhibition ( PI ) was studied in the rat . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The activity of free tissue plasminogen activator ( f tPA ) and plasminogen activator inhibitor ( PAI ) in the plasma of 82 noninsulin dependent diabetics ( NIDDM ) was measured by bioimmunoassay of the euglobulin fraction obtained from the plasma , and the levels were compared with those of age and gender matched normal subjects . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Significant changes occur in the concentrations of platelets and white blood cells , hematocrit ( Ht ) , von Willebrand factor antigen ( vWF : ag ) , antithrombin 3 activity ( AT 3 ag ) , antithrombin 3 antigen ( AT 3 ant ) , fibrinogen , plasminogen , alpha 2 antiplasmin ( alpha 2 AP ) , histidine rich glycoprotein ( HRG ) , and plasminogen activator inhibitor ( PAI ) activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen , plasmin , and plasminogen activator ( PA ) activities and PA and PA inhibitor ( PAI ) contents were measured in granulosa ( GC ) and theca interna cell extracts and follicular fluid ( FF ) obtained from preovulatory follicles of prepubertal gilts treated with eCG and hCG to induce follicular growth and ovulation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In addition , no evidence of possible involvement of plasminogen activator ( PA ) enzymes and of their inhibitors ( PAI ) in the spreading ability of NQ 22 cells was observed . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have now investigated whether receptor bound uPA also retains the ability to react with and be inhibited by plasminogen activator inhibitors ( PAI 1 and PAI 2 ) . uPA bound to its receptor on human U 937 monocyte like cells was inhibited by PAI 1 ( in its active form in the presence of vitronectin fragments ) with an association rate constant of 4 . 5 10 10 ( 6 ) M 1 s 1 , which was 40 % lower than that obtained for uPA in solution ( 7 . 9 10 10 ( 6 ) M 1 s 1 ) . ^^^ These constants although lower than those for uPA in solution still represent rather rapid inhibition of the enzyme , and demonstrate that uPA bound to its specific cellular receptor remains available for efficient inhibition by PAI ' s , which may therefore play a major role in controlling cell surface plasminogen activation and extracellular proteolytic activity . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Further analysis revealed that this apparent decrease in PA release was in fact due to an increased release of plasminogen activator inhibitor ( PAI ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To assess changes in fibrinolysis , we studied levels of plasminogen activator inhibitor ( PAI ) , an inhibitor of the fibrinolytic cascade . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
That ancrod acted rapidly was shown by a significant decrease in functional plasminogen activator inhibitor ( PA 1 ) within 60 minutes , and by significant elevations of fibrin ( ogen ) degradation products ( FDP ) and D dimer within 3 and 4 hours . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the basal condition , plasminogen activator inhibitor ( PAI ) activity was significantly higher in patients with exercise induced ischemia as compared to control subjects ( p less than 0 . 01 ) , although there were no significant differences in other fibrinolytic variables between the two groups . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Because TGF beta stimulates fibronectin expression in cultured human keratinocytes , we wished to determine whether it might also affect ECM degradation through the plasminogen activator ( PA ) plasminogen activator inhibitor ( PAI ) system . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The 110 kDa protein co migrated with the PA PAI complexes and the 60 kDa protein co migrated with tissue Plasminogen Activator ( tPA ) . ^^^ Functional and immunological assays indicated the human TNF alpha increased the type 1 plasminogen activator inhibitor ( PAI 1 ) in a time dependent manner . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activators ( PA ) and plasminogen activator inhibitors ( PAI ) have been implicated in the process of extracellular matrix degradation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
There was a markedly significant increase of plasma levels of tissue type plasminogen activator , plasminogen activator inhibitor 1 ( PAI 1 ) and PAI activity in 3 patients with hemophagocytic histiocytosis ( HPH ) as compared with DIC patients with multi organ failure ( MOF ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Mainly bilateral ovariectomy induced variable changes of plasminogen activator activity ( PAA ) , plasminogen activator inhibition ( PAI ) and plasmin inhibition ( PI ) in key organs ( brain , lungs , heart , aorta and kidneys ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The levels of plasminogen activator ( PA ) and plasminogen activator inhibitor ( PAI ) in the conditioned media of the various aggregate types were measured . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A promyelocytic leukemia cell line , PL 21 , was found to produce an inhibitor of plasminogen activators ( PAI ) . ^^^ The PAI inhibited not only urokinase type plasminogen activator ( u PA ) but single and two chain tissue type plasminogen activators ( t PAs ) on plasminogen containing fibrin plate . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
However , glucagon and epinephrine augmented the activity , whereas dexamethasone suppressed it by lowering the production of hepatic PA rather than by inducing plasmin inhibitors or a plasminogen activator inhibitor ( PAI ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The levels of plasminogen activator inhibitor ( PAI ) , protein C ( pC ) , total cholesterol ( TC ) , high and low density lipoprotein cholesterols ( HDLC and LDLC ) , apolipoproteins A 1 ( apoA 1 ) and B ( apoB ) were measured in 45 patients with coronary heart disease angiographically documented and 10 healthy subjects without coronary heart disease and coronary atherosclerosis as evidenced by coronary angiography and provocative tests . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Activation of platelets and augmentation of plasma plasminogen activator inhibitor ( PAI ) type 1 activity accompany acute myocardial infarction . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have examined the effect of thrombin on the activity of plasminogen activator ( PA ) and plasminogen activator inhibitor ( PA 1 ) in medium conditioned by primary cultures of human umbilical vein endothelial cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The only one found in the plasma of nonpregnant women ( PAI 1 ) is immunologically related to a PAI of endothelial cells ; its plasma activity , as deduced from the inhibition of single chain tissue type plasminogen activator ( t PA ) , increased from 3 . 4 + / 2 . 3 U / mL ( mean + / 95 % confidence limits ) in the plasma of nonpregnant women to 29 + / 7 U / mL at term , and its antigen level , measured by a radioimmunoassay , increased from 54 + / 17 ng / mL to 144 + / 25 ng / mL . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
During this period statistically significant increases in tissue plasminogen activator levels were noted but were overshadowed by a dramatic decrease in the level of plasminogen activator inhibitor ( PAI ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor ( PAI ) purified from human placenta was compared to PAI purified from conditioned cell culture fluid of the human fibrosarcoma cell line HT 1080 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A binding protein for plasminogen activator inhibitor 1 ( PAI 1 BP ) was isolated from human plasma by a four step procedure . 1 ) The 7 S globulin fraction of plasma was isolated by gel filtration on Sephacryl S 300 . 2 ) Human endothelial cell type plasminogen activator inhibitor ( PAI 1 ) , pretreated with 12 M urea , was added to this fraction ( 22 micrograms of PAI 1 / ml of plasma ) , and a PAI 1 antigen peak with apparent mass 450 kDa ( representing 65 % of PAI 1 antigen and 85 % of PAI activity ) was isolated by gel filtration of this mixture . 3 ) The PAI 1 . ^^^ PAI 1 BP complex was further purified by immunoadsorption on an immobilized murine monoclonal antibody directed against PAI 1 ( MA 7D4 ) and by elution with 4 M KSCN . 4 ) The complex was then dissociated by addition of excess human tissue type plasminogen activator ( t PA ) , and t PA and PAI 1 antigen ( t PA . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI ) is bound to vitronectin in plasma . ^^^ Functionally active plasminogen activator inhibitor 1 ( PAI ) is bound to a discrete binding protein in plasma [ ( 1988 ) Thromb . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is an important physiological inhibitor of fibrinolysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Affinity purification of active plasminogen activator inhibitor 1 ( PAI 1 ) using immobilized anhydrourokinase . ^^^ Human Hep G 2 hepatoma and HT 1080 fibrosarcoma cells were cultured in large scale under conditions which allowed enhanced secretion of plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To evaluate the roles of plasminogen activator ( PA ) and PA inhibitor ( PAI ) in human ovulation , we obtained follicular fluid and granulosa cells from individual preovulatory follicles of patients undergoing gamete intrafallopian tube transfer . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Since the functional activity of plasminogen activators is determined not only by the quantity of protease but also by levels of specific plasminogen activator inhibitors ( PAI ) , we examined trophoblasts both in vitro and in vivo for the presence of two PAIs , PAI 1 and PAI 2 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The length of the tubes formed were measured morphometrically using an image analyzer in the absence and presence of fibrinolytic proteases , namely plasminogen , plasminogen activators ( PAs ) and PA inhibitor ( PAI ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor ( PAI ) capacity was not significantly different in the two groups before venous occlusion ( VO ) but differed slightly ( p less than 0 . 05 ) after VO . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Functionally active ( high Mr ) and inactive ( low Mr ) plasminogen activator inhibitor 1 ( PAI ) have been purified from fibrosarcoma cell line HT 1080 conditioned medium , containing 1 % fetal calf serum . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue plasminogen activator ( tPA ) , plasminogen activator inhibitor ( PAI ) , and lipoprotein Lp ( a ) were measured in citrated plasma samples . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The following factors were studied in the immediate preoperative period , at different surgical times throughout the procedure and 2 3 h after the end of the abdominal sutures : platelet count , prothrombin concentration , fibrinogen , activated kephalin time , factors 2 , 5 , 7 + 10 and VIIIc , antithrombin 3 , protein C , D dimers , fibrinogen and fibrin degradation products ( PDF ) , plasma plasminogen , tissue plasminogen activator ( tPA ) and the fast tPA inhibitor ( PAi ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
It is known that either endotoxin ( LPS ) or interleukin 1 ( IL 1 ) increase the activity of plasminogen activator inhibitor ( PAI ) in the culture media of human and bovine endothelial cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Corneal epithelial cells secrete tissue plasminogen activator ( t PA ) , urokinase type plasminogen activator ( u PA ) and their inhibitor ( PAI ) , whereas these cell types in other tissues are known to secrete only u PA hitherto . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In group 2 a gradual increase of tissue type plasminogen activator ( t PA ) activity was seen during the anhepatic stage , followed by an `` explosive ' ' increase immediately after graft reperfusion ( P = 0 . 0004 , compared with group 1 ) , and a reduction of plasminogen activator inhibitor ( PAI ) activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Some of the fibrinolytic and coagulation enzymes that monocytes produce are urokinase , a plasminogen activator ( PA ) ; a PA specific inhibitor ( PAI ) ; and procoagulant activity ( PCA ) , which has been characterized as tissue factor . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The effects of nicotine and its major metabolite , cotinine , were evaluated on the secretion of plasminogen activator ( PA ) and plasminogen activator inhibitor ( PAI ) in cultured bovine aortic endothelial cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Although t PA was uniformly low in both groups , plasminogen activator inhibitor activity ( PAI ) was significantly higher in LA cases ( p less than 0 . 001 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In control animals , reduced levels of prothrombin , antithrombin , kallikrein inhibitors , antiplasmin , and increased level of plasminogen activator inhibitor ( PAI ) indicated systemic activation of the coagulation , kallikrein kinin , and fibrinolytic systems . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This report defines the nature of the molecules responsible for the increased plasma plasminogen activator inhibitor ( PAI ) activity in preeclamptic patients and the relationship of these inhibitors to the severity of placental damage in preeclampsia . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor ( PAI ) was purified in active form from porcine platelets under nondenaturing conditions . ^^^ The purified inhibitor ( Mr 47 , 000 ) reacts with tissue type plasminogen activator ( t PA ) , urokinase ( UK ) , and activated protein C ( APC ) to yield both SDS stable complexes and a modified PAI of slightly reduced molecular weight . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Several fibrinolytic variables , including plasminogen activator inhibitor ( PAI ) activity and PAI 1 antigen , were studied before and after an ergometric test performed at three different times : at the end of hospitalization ( before beginning the rehabilitation programme ) , three months and six months after myocardial infarction . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
On the other hand , important modifications of fibrinolytic parameters occurred , essentially concerning tissue type plasminogen activator ( t PA ) and its specific inhibitor ( PAI ) . t PA activity constantly increased in the course of transplantation , reaching a maximum at the end of anhepaty . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Low plasma testosterone and high levels of the rapid inhibitor of plasminogen activator ( PA 1 ) have been proposed as risk factors for myocardial infarction . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue plasminogen activator ( t PA ) , the antigen and its biological activity and , the activity of plasminogen activator inhibitor ( PAI ) : were measured in twenty two healthy women during and shortly after spontaneous delivery ( 2nd stage and 3rd stage of labour , 48 and 72 hours post partum ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
There is a negative correlation between plasminogen activator inhibitor ( PAI 1 ) and HDL cholesterol ( r = 0 . 37 , p less than 0 . 05 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Increased levels of plasminogen activator inhibitor ( PAI ) have recently been described in patients with acute myocardial infarction ( AMI ) . ^^^ To correlate PAI levels to patency of infarct arteries after thrombolytic therapy with recombinant tissue type plasminogen activator ( rt PA ) , 125 consecutive patients with AMI were examined . ^^^ Blood levels of fibrinogen , plasminogen , tissue plasminogen activator ( t PA ) and PAI were measured before treatment initiation , 10 minutes after completion of rt PA infusion and 24 and 48 hours after treatment . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The differentiation induced by PMA , RA , and to a lesser extent DMSO , was accompanied by the induction of plasminogen activator inhibitor expression . mRNA analysis of control and PMA induced cultures revealed the induction of a 2 kb message in treated cells which hybridized with a PAI 2 specific oligonucleotide probe . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In this case , marked increase in total plasminogen activator inhibitor 1 ( PAI 1 ) antigen , mainly due to free PAI 1 antigen , was observed in basal conditions before the onset of acute myocardial infarction . ^^^ On the appearance of ischaemia , plasminogen activator activity was suppressed , probably due to decreased tissue plasminogen activator antigen release and increased PAI activity , compared with that during convalescence . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue plasminogen activator ( t PA ) activity , t PA antigen ( t PA : Ag ) and t PA inhibitor activity ( PAI ) were measured at rest and during venous occlusion ( VO ) for 10 and 20 min in 21 healthy subjects and 80 patients with venous thromboembolic disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Determination of plasminogen activator inhibitor ( PAI ) activity of human plasma after dilution in a PAI depleted plasma . ^^^ A simple and discriminating assay for the determination of the fast acting plasminogen activator inhibitor ( PAI ) activity in human plasma is described . ^^^ The method is based on the inhibition of purified tissue plasminogen activator ( tPA ) by plasma diluted with a PAI depleted plasma and the subsequent measurement of residual tPA in the presence of CNBr fibrinogen fragments , purified plasminogen and a plasmin sensitive chromogenic substrate CBS 10 . 65 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
High levels of plasminogen activator inhibitor ( PAI ) in the non responder group explain this discrepancy . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
MSF contains elevated amounts of plasminogen activator inhibitor ( PAI ) when measured either as bioactivity or in an ELISA . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibition ( PAI ) was at the same level in all layers of the arteries studied . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activity and antigen , tissue type plasminogen activator ( tPA ) activity and antigen , plasminogen activator inhibitor ( PAI ) activity , and plasmin generation rates were determined in 32 normal newborn plasmas and 25 normal adult plasmas . ^^^ The newborns showed reduced levels of plasminogen activity and antigen and tPA antigen , and activity , normal levels of PAI activity , and slower plasmin generation rates . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator activity ( PAA ) and plasminogen activator inhibition ( PAI ) showed a tissue and time dependent pattern of changes in some key organs compared to controls ( sham operated rats ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Five maturational agents retinoic acid , dibutyryl cAMP , 5 bromodeoxyuridine , sodium butyrate and phorbol myristate acetate were tested for their effects on cellular morphology , DNA synthesis , plasminogen activator ( PA ) and PA inhibitor ( PAI ) activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We compared urokinase type plasminogen activator ( u PA ) in fluid phase and u PA bound with its receptor on human blood monocytes with respect to proteolytic activity and susceptibility to inactivation by the plasminogen activator inhibitors PAI 1 and PAI 2 . ^^^ Thus , competition of u PA / PAI complexes with fluid phase u PA for binding to the receptor is unlikely to affect the overall plasminogen activator activity of the monocyte . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The procoagulant response of endothelium to many stimuli alters the expression of tissue factor , thrombomodulin , and plasminogen activator inhibitors ( PAI ) PAI 1 and PAI 2 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In addition , endothelium is involved in the regulation of fibrinolysis by releasing soluble factors , such as tissue plasminogen activator ( tPA ; [ 10 ] ) and plasminogen activator inhibitor ( PAI ; [ 22 , 11 ] ) , as well as in the control of vascular responsiveness by the production of smooth muscle relaxing and contracting factors . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We observed a significant change in the activity of tissue type plasminogen activator ( t PA ; p less than 0 . 01 ) and in the activity of plasminogen activator inhibitor ( PAI ; p less than 0 . 001 ) during 24 h . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The relationship between plasminogen activator ( PA ) / plasminogen activator inhibitor ( PAI ) activity and morphological differentiation was investigated in human neuroblastoma ( NB ) cells treated with retinoic acid ( RA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To elucidate the role of protein C ( PC ) in the release of plasminogen activator inhibitor ( PAI ) from endothelial cells , the effect of PC and activated protein C ( APC ) on plasma levels of PAI in endotoxin ( ET ) treated rats was examined . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Type 2 diabetic patients are known to frequently have a high insulin level and were recently described as having high plasminogen activator inhibitor ( PAI ) activity , compared to normal controls . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma concentrations of urokinase plasminogen activator ( u PA / competitive radioimmunoassay ) , tissue type plasminogen activator ( t PA / sandwich ELISA ) and plasminogen activator inhibitor ( PAI / functional assay ) were determined in 44 women ( age : 24 . 3 + / 4 . 3 years ) with normal pregnancy near term . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Elevated plasminogen activator inhibitor ( PAI ) , a cause of thrombophilia . ^^^ Two hundred and three patients with venous thrombophilia were investigated in order to find out whether an elevated plasma concentration of plasminogen activator inhibitor ( PAI ) could be a cause of their tendency to thrombosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
It has been experimentally shown that endotoxin induces a significant increase in the blood levels of a plasminogen activator inhibitor ( PAI ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Neither fish oil or wheat germ oil caused any significant change in tissue plasminogen activator ( tPA ) or its inhibitor ( PAI ) measured enzymatically or in tPA antigen measured by an ELISA method . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In plasma of IBD patients significantly decreased tissue type plasminogen activator activity ( t PA ) ( p less than 0 . 02 ) , increased plasminogen activator inhibition ( PAI ) ( p less than 0 . 01 ) and fibrinogen ( p less than 0 . 001 ) , and prolonged thrombin time ( p less than 0 . 001 ) and prothrombintime ( p less than 0 . 001 ) were found . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The amino acid sequence shows 23 to 28 % homology to those of five other protease inhibitors , plasminogen activator inhibitor ( PAI ) , protein C inhibitor ( PCI ) , alpha 1 antitrypsin ( alpha 1 AT ) , antithrombin 3 ( AT 3 ) , and alpha 1 antichymotrypsin ( alpha 1 AC ) . alpha 2 PI seems to be the most distantly related among these inhibitors . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The PA 1 inhibited the tissue type plasminogen activator , and also that of the two chain form of urokinase , but not the one chain form . ^^^ The 55 , 000 molecular weight PA 1 band in PcMEM reacted with antibodies against plasminogen activator inhibitors produced by bovine vascular endothelial cells , or by human fibrosarcoma cells , as detected by immunoadsorption experiments , by immunoblotting , and by reverse fibrin autography . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The fibrinolytic system was monitored by analysing : plasminogen , alpha 2 antiplasmin , fibrin ( ogen ) degradation products ( FDP ) , euglobulin clot lysis time ( ECLT ) , tissue plasminogen activator ( t PA ) activity , t PA antigen and plasminogen activator inhibitor ( PAI ) activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Nor was spontaneous release of tissue plasminogen activator ( t PA ) or of its inhibitor ( PAI ) modified in the presence of patient ' s IgG . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Ascitic fluid from tumour patients ( hepatoma , gastric cancer , gallbladder cancer , colorectal cancer , ovarian cancer ) and from non malignant diseases ( liver cirrhosis , congestive heart failure ) were compared with respect to their content of determinants of the fibrinolytic system , tissue type plasminogen activator antigen ( t PAag ) and activity ( t PAact ) , urokinase type plasminogen activator antigen ( u PA ) and plasminogen activator inhibitor activity ( PAI ) . ^^^ It is concluded that t PA is the physiological plasminogen activator in ascites and that increased PAI levels followed by increased complex formation between t PA and PAI might reflect a reaction of the peritoneum . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Treatment with both glutathione depleting agents induced a significant reduction in the functional activity of tissue plasminogen activator ( t PA ) ( 61 % and 27 % respectively for buthionine sulphoximine or diethyl maleate ) and a significant increase in that of plasminogen activator inhibitor ( PAI ) ( +61 % and +27 % respectively ) , while alpha 2 antiplasmin activity was not modified . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Platelets stimulated with thrombin release an inhibitor of plasminogen activator ( PAI ) , which has been shown previously to be neutralized by activated protein C ( APC ) . ^^^ When 6 10 10 ( 8 ) platelets / mL were incubated with thrombin ( 1 IU / mL ) , the releasate contained 18 to 26 ng / mL PAI as determined by incubation of the releasate with urokinase and measurement of residual urokinase activity on plasminogen ( S 2251 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have previously demonstrated that plasminogen activator inhibitor ( PAI 1 ) is associated with the extracellular matrix of cultured bovine smooth muscle cells ( Knudsen , B . ^^^ In this report we describe the physiologic role of PAI 1 during the interaction of the tissue plasminogen activator ( t PA ) secreting Bowes human melanoma cell line with endothelial extracellular matrices . ^^^ PAI complexes formed during this interaction in the presence and absence of plasminogen . ^^^ In the absence of plasminogen , a 104 kDa complex between Bowes t PA and PAI 1 appears in the supernatant . ^^^ In the presence of plasminogen , PAI initially prevents plasmin formation on the matrix and protects the matrix from degradation by plasmin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The effect of endotoxin , aspirin and endotoxin after administration of aspirin on the tissue plasminogen activator activity ( PAA ) , plasminogen activator inhibition ( PAI ) and plasmin inhibition ( PI ) was studied in the rat . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
DNA cloning and expression in E . coli of a plasminogen activator inhibitor ( PAI ) related to a PAI produced by Hep G 2 hepatoma cell . ^^^ The human hepatoma line Hep G 2 produces an acid and SDS sensitive plasminogen activator inhibitor ( PAI ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Two nearly full length cDNAs for placental plasminogen activator inhibitor ( PAI ) have been isolated from a human placenta lambda gt 11 cDNA library . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We report the production , purification , characterization , and partial amino acid sequence of a plasminogen inhibitor ( PA 1 ) . ^^^ PA 1 migrates as a closely spaced doublet of 47 kDa in sodium dodecyl sulfate polyacrylamide gel electrophoresis and forms covalent complexes with urokinase and two chain tissue type plasminogen activator , displaying second order rate constants of 0 . 9 10 10 ( 6 ) M 1 s 1 and 0 . 2 10 10 ( 6 ) M 1 s 1 , respectively . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Conditioned media collected from IL 1 treated ( 5 U / ml , 24 h ) monolayers exhibited decreased tissue type plasminogen activator ( tPA ) activity and increased plasminogen activator inhibitor ( PAI ) activity , as assessed by fibrin and reverse fibrin autography . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The rapidly acting plasminogen activator inhibitor ( PAI ) purified from cultured bovine aortic endothelial cells ( BAEs ) was inactivated during iodination with chloramine T and other oxidizing iodination systems . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The secretion of tissue type plasminogen activator antigen ( t PA Ag ) and fast acting plasminogen activator inhibitor activity ( PA 1 activity ) was measured in the conditioned medium after incubation of confluent cultures with serum free medium for 24 hours ( 1 . 5 ml / 25 cm 2 cell surface ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma levels of a fast acting plasminogen activator inhibitor ( PAI ) , which neutralizes both tissue plasminogen activator ( t PA ) and urokinase , are markedly increased in endotoxin treated rabbits . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Immunol . , 71 : 215 223 ) and concomitantly stimulates the biosynthesis of plasminogen activator inhibitor 2 ( PAI 2 ) and of urokinase type plasminogen activator ( u PA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The plasma tPA inhibitor complex is precipitated strongly by antisera against plasminogen activator inhibitors ( PAIs ) of human Hep G 2 hepatoma and HT 1080 fibrosarcoma cells and weakly by antiserum against bovine aortic endothelial cell PAI but not by antiserum against a placental PAI ( PAI 2 ) suggesting that the plasma inhibitor is immunologically related to Hep G 2 , HT 1080 and possibly endothedial cell PAIs . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We found no effect of Sorbinil on the activity of the fast reacting inhibitor ( PA 1 ) of plasminogen activator . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In this combined assay system t PA functional activity was found to depend not only on the amount of t PA antigen but also on the amount of plasminogen activator inhibitor ( PAI ) , whereas in the t PA antigen assay PAI did not affect the results . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Preoperatively , and repeated on the 3 . postoperative day , assays of euglobulin clot lysis time ( ELT ) after venous stasis , tissue plasminogen activator ( t PA ) and plasminogen activator inhibitor ( PAI ) were performed . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Mouse resident peritoneal macrophages synthesize two plasminogen activator specific inhibitors ( PAI ) that are functionally and antigenically related , but differ in their apparent Mr and oligosaccharide content . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To study the effect of plasminogen activator inhibitors ( PAI ) on fibrinolysis it is essential to be able to specifically measure these proteins in plasma . ^^^ A radioimmunoassay was developed that measures both free and tissue type plasminogen activator ( t PA ) bound PAI 1 in plasma and has an effective range of 8 to 250 ng / mL . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Serum free conditioned medium from L cells or L cells treated with the tumor promotor phorbol myristate acetate ( PMA ) was analyzed for plasminogen activator ( PA ) and plasminogen activator inhibitor ( PAI ) activity . ^^^ The L cell PAI formed SDS stable complexes with purified human ( homo sapiens ) urokinase and tissue plasminogen activator , as well as , mouse ( Mus musculus ) urinary PA . 4 . ^^^ These results indicate that biochemical and immunological differences between human and mouse urokinase and human urokinase and human tissue plasminogen activator do not influence the interaction of the L cell PAI with these enzymes . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Immunodepletion of urokinase from conditioned medium revealed high levels of a fully active plasminogen activator inhibitor ( PAI ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The site of the reaction between plasminogen activators and plasminogen activator inhibitor 1 ( PAI 1 ) was investigated in cultures of human umbilical vein endothelial cells . ^^^ However , the addition of increasing concentrations of tissue type plasminogen activator ( t PA ) or urokinase to confluent endothelial cells produced a saturable ( 3 . 0 pmol / 5 10 10 ( 5 ) cells ) , dose dependent increase of the activator PAI 1 complex in the conditioned medium even in the presence of actinomycin D or cycloheximide . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Vascular or tissue type plasminogen activator ( plasma t PA ) is the circulating physiological fibrinolytic enzyme of endothelial cell origin which function is regulated by fibrin and a specific inhibitor ( PAI ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The effects of sulfonylureas on the production of plasminogen activator ( PA ) and antiactivator ( PAI ) were investigated using bovine aortic endothelial cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Reference values of tissue type plasminogen activator ( t PA ) antigen , t PA activity , and plasminogen activator inhibitor ( PAI ) were established in healthy blood donors using different assay systems . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To test this hypothesis 12 patients undergoing infrarenal aortic reconstruction due to arteriosclerotic disease were evaluated for influence of the respiratory pattern on release of tissue plasminogen activator ( t PA ) and its inhibitor ( PAI ) in systemic and pulmonary arterial blood . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We used specific , sensitive assays for plasma tissue type plasminogen activator ( t PA ) antigen , t PA activity , plasminogen activator inhibitor ( PAI ) activity , plasminogen , and alpha 2 plasmin inhibitor ( alpha 2 PI ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Epidermal plasminogen activator inhibitor ( PAI ) is immunologically identical to placental type PAI 2 . ^^^ Plasminogen activator inhibitor ( PAI ) purified from human epidermis [ ( 1986 ) FEBS Lett . 408 , 273 277 ] was immunologically identified as placental type PAI 2 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor ( PAI ) activity fell following DDAVP and became undetectable in some subjects during the sampling period . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The results from tests of euglobulin lysis time , t PA activity , t PA antigen levels , and t PA fast acting inhibitor ( plasminogen activator inhibitor [ PAI ] ) level were compared with those obtained after venous occlusion . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
After isolation , the cultures were grown to confluency and then studied under identical conditions for release of tissue plasminogen activator ( t PA ) antigen and plasminogen activator inhibitor ( PAI ) into serum free medium . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Ovarian follicles produce two types of plasminogen activator ( tPA and uPA ) , and their inhibitor ( PAI ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor ( PAI ) activity and plasminogen activator inhibitor 1 ( PAI 1 ) 1 antigen levels at rest showed considerable dispersion ranging from 1 . 9 to 12 . 4 U / ml , respectively 6 . 9 to 77 ng / ml . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A two stage method for determination of plasminogen activator inhibitor ( PAI ) activity in blood plasma is described . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The reactions between plasminogen activator inhibitor ( PAI ) and different plasminogen activators were studied in the presence of chromogenic peptide substrates for the enzymes . ^^^ Our findings suggest that the rate constants for the reactions of PAI with single chain tissue plasminogen activator ( tPA ) , two chain tPA , high Mr urokinase and low Mr urokinase are high and quite similar ( 1 . 6 10 10 ( 7 ) 3 . 9 10 10 ( 7 ) M 1 . s 1 ) . ^^^ However , di isopropyl phosphorofluoridate inactivated tPA inhibited the reaction between PAI and all plasminogen activators in a similar way . ^^^ The phenomenon might be of physiological relevance , in the sense that single chain tPA bound to fibrin in the presence of plasminogen would be protected against inactivation by PAI . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Blood was collected at least 3 months after the last acute episode , and PAI 1 antigen and activity , as well as tissue type plasminogen activator ( t PA ) antigen , urokinase type plasminogen activator ( u PA ) antigen , and fibrinolytic activity were measured in these samples . ^^^ During venous stasis , plasminogen activator inhibitor ( PAI ) activity decreased in almost all patients ( 81 of 83 ) , from a median value of 8 . 2 to 2 . 9 U / mL ( P less than . 001 , Wilcoxon signed rank test ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Human rTNF / Cachectin was shown to stimulate gene transcription of plasminogen activator inhibitor ( PA 1 ) 1 and PAI 2 , and simultaneously suppress constitutive gene expression of tissue type plasminogen activator ( t PA ) in human fibrosarcoma cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Determination of plasminogen activator inhibitor ( PAI ) capacity of human plasma in presence of oxidants : a novel principle . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The effects of the polyamines putrescine ( PUT ) , spermidine ( SPD ) , and spermidine ( SPM ) on the secretion of plasminogen activator ( PA ) and plasminogen activator inhibitor ( PAI ) were evaluated using cultured bovine aortic endothelial cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The granulosa cells of 49 follicles from 20 patients undergoing in vitro fertilization were obtained by laparoscopy and tested for the content of urokinase type plasminogen activator ( u PA ) , tissue type plasminogen activator ( t PA ) and inhibitor of plasminogen activator ( PAI ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Mononuclear phagocytes are known to produce both urokinase type plasminogen activator ( u PA ) and a specific PA inhibitor , PAI 2 . ^^^ PA and PAI activities of conditioned media and cell lysates were measured with a plasminogen dependent colorimetric assay . ^^^ The ability of mononuclear phagocytes to control plasminogen activation at inflammatory foci may therefore be contingent on the independent regulation of u PA and PAI 2 gene expression . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Platelets and endothelium are sources of plasminogen activator inhibitor ( PAI ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We investigated relationship between cigarette smoking and fibrinolytic system , namely the plasma level of t PA antigen , plasminogen activator inhibitor ( PAI ) , and PA activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Before ergometry , healthy participants with regular sporting activities showed significantly lower plasma plasminogen activator inhibitor capacities ( PAI cap ) than the members of the respective age matched control groups : Group A 13 . 9 + / 2 . 6 AU / ml , Group B 18 . 5 + / 5 . 5 , p less than 0 . 005 ; Group C 15 . 2 + / 2 . 9 , Group D 20 . 7 + / 5 . 5 , p less than 0 . 05 . ^^^ During ergometry the release of tPA antigen did not differ significantly between the age matched groups , however , tissue plasminogen activator ( tPA ) activities after ergometry were higher in groups presenting lower pre test PAI cap values . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The vascular endothelium plays an important role in fibrinolysis by producing tissue type plasminogen activator ( t PA ) and plasminogen activator inhibitor ( PAI ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The plasminogen activator inhibitor ( PAI ) had an increased activity in 5 out of the 10 patients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
It has been experimentally shown that endotoxin induces a marked increase in the levels of a fast acting inhibitor of plasminogen activator ( PAI ) . ^^^ The plasma PAI activity and tissue type plasminogen activator ( t PA ) concentrations were measured in 61 patients with human septicaemia and results were compared with those observed in healthy controls . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The following tests were performed : euglobulin clot lysis time ( ECLT ) , fibrinolytic activity of euglobulins on fibrin plates in the presence and absence of blocking antibodies to tissue type plasminogen activator ( t PA ) and / or urokinase ( u PA ) , overall plasminogen activator inhibitor ( PAI ) activity , antigen levels of t PA , u PA and PAI 1 and zymography of the euglobulin fraction after SDS PAGE . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The plasma levels of plasminogen activator inhibitor ( PAI ) in 29 patients with obstructive jaundice were found significantly increased as compared to 20 nonjaundiced patients . ^^^ Fibrin autography of plasma supplemented with tissue plasminogen activator ( t PA ) revealed that in icteric samples most of the added activator migrated with an apparent Mr of 100 kDa , corresponding to t PA PAI complex , whereas in control samples virtually all t PA migrated as free enzyme . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Using specific assays for tissue plasminogen activator ( t PA ) activity , t PA inhibitor ( PAI ) and t PA antigen , we measured these activities in 16 women who developed DVT during their pregnancies . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The effects of maturation inducing agents on the production of plasminogen activator ( PA ) and plasminogen activator inhibitor ( PAI ) by the human promyelocytic leukemia cell line HL 60 were examined . ^^^ Cells that were induced with PMA but not with RA or DMF also produced an inhibitor to UK that was identified as PAI 2 , the plasminogen activator inhibitor that is produced by monocytes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The plasminogen activator ( PA ) and plasminogen activator inhibitor ( PAI ) in synovial fluid ( SF ) of osteoarthritis ( OA ) were examined to clarify their pathophysiological roles in this disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We determined plasminogen activator ( PA ) and PA inhibitor ( PAI ) activities in the intra and extracellular compartments of an experimental pancreatic ascites tumour with indirect and direct functional assays , and partially characterized these activities on SDS polyacrylamide gels coupled with fibrin and reverse fibrin autography . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tumor necrosis factor ( TNF ) stimulates plasminogen activator inhibitor ( PAI ) production by endothelial cells and decreases blood fibrinolytic activity in the rat . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Cultured endothelial cells ( ECs ) produce type 1 PAI ( PAI 1 ) , the physiologic inhibitor of tissue type plasminogen activator . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To investigate whether juvenile cerebral infarction is associated with a permanent defect of the fibrinolytic system we measured the main components of the fibrinolytic system , tissue plasminogen activator ( t PA ) and its fast acting inhibitor ( PAI ) in plasma samples of 21 patients ( aged 21 44 years ) 3 24 months after the acute event . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Defective fibrinolysis can also be due to increased concentration of tissue plasminogen activitor inhibitor ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A decrease in the fibrinolytic potential , mainly due to an elevation of plasminogen activator inhibitor ( PAI ) , has been described in patients with stable coronary artery disease and a previous myocardial infarction . ^^^ We investigated plasma levels of PAI and tissue plasminogen activator ( t PA ) and their possible circadian variations in patients with unstable coronary artery disease ( CAD ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Clot lysis of HOTMEC could be blocked by anti tPA IgG but was not affected by the incorporation of exogenous plasminogen activator ( PAI ) into the clot in concentrations ( 75 arbitrary units ) exceeding the tPA activity ( 21 + / 2 . 5 IU ) of the cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Secretion of plasminogen activator inhibitor 1 ( PAI 1 ) by cultures of human umbilical vein endothelial cells and human hepatocellular cell line Hep G 2 was evaluated after insulin stimulation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
An enzyme linked immunosorbent assay for plasminogen activator inhibitor 1 ( PAI 1 ) in biologic fluids was developed on the basis of two murine monoclonal antibodies raised against PAI 1 purified from HT 1080 fibrosarcoma cells . ^^^ The assay is 12 times less sensitive toward the PAI 1 / human tissue type plasminogen activator ( t PA ) complex as compared with free PAI 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This report describes the development and use of functional immunoradiometric assays that distinguish the activity of beta migrating endothelial type plasminogen activator inhibitor ( PAI 1 ) from that of placental type plasminogen activator inhibitor ( PAI 2 ) . ^^^ These assays are based upon the binding of PAI 1 and PAI 2 to immobilized single chain tissue type plasminogen activator ( tPA ) and to immobilized urokinase ( UK ) , respectively . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Levels of plasminogen activator inhibitor type 1 ( PAI ) were measured in 180 patients with angina pectoris ( 148 males and 32 females , age range 29 to 70 years ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The influence of age , gender , and aspirin ingestion on plasma levels of tissue plasminogen activator ( t PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) activities was studied in a reference population of 35 men and 35 women between the ages of 20 and 65 years . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Both cell types reacted with an increase in plasminogen activator inhibitor ( PAI ) activity and a decrease in the plasminogen activator ( PA ) activity in the media after incubation under anoxic conditions . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Purification and characterization of natural and recombinant human plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^ Human plasminogen activator inhibitor 1 ( PAI 1 ) was purified from the conditioned medium of endotoxin stimulated umbilical vein endothelial cell cultures by combinations of zinc chelate Sepharose chromatography , gel filtration on Sephacryl S 300 and immunoadsorption on an insolubilized murine monoclonal antibody ( MA 7D4 ) . ^^^ SDS gel electrophoresis of the isolated high Mr fraction revealed several bands including a main 46 , 000 Mr component , which reacted with anti ( PAI 1 ) antibodies on immunoblotting and neutralized tissue type plasminogen activator ( t PA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A plasminogen activator inhibitor ( PAI ) was purified from bovine endothelial cell conditioned medium by a simple procedure in the absence of protein denaturant . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the rat , gonadotropins appear to increase granulosa cell tissue type plasminogen activator ( t PA ) content by increasing the cellular concentration of t PA mRNA as well as by modulating the activity of a specific PA inhibitor ( PAI ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The plasminogen activator inhibitor ( PAI ) activity was also measured in each session before fibrinolysis stimulation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The content of tissue plasminogen activator inhibitor ( t PA 1 ) , and of specific pregnancy plasma PA 1 reacting with antibodies to placental PA 1 , was measured in platelet poor plasma ( PPP ) , platelet rich plasma ( PRP ) , serum and platelet lysate , both from pregnant women and healthy non pregnant ( male or female ) controls . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We report here the identification and preliminary characterization of the messenger RNA coding for a Mr 50 , 000 plasminogen activator inhibitor ( PAI ) synthesized by cultured bovine aortic endothelial cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Glucocorticoids decrease plasminogen activator ( PA ) activity in HTC rat hepatoma cells by inducing a specific inhibitor of PA activity ( PAI ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Anti plasmin and plasminogen activator inhibitor ( PAI ) activity were lower in the rabbit than in man . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Enhancement by interleukin 1 ( IL 1 ) of plasminogen activator inhibitor ( PA 1 ) activity in cultured human endothelial cells . ^^^ The PA 1 measured in cell extracts was SDS resistant with an apparent m . w . of 53 Kd and inhibited both tissue type plasminogen activator ( t PA ) and urokinase ( UK ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The conditioned media of two cell lines ( KRFM and MJZJ ) were found to contain plasminogen activator inhibitor ( PAI ) activity at a Mr position of approximately 50 , 000 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Specific plasminogen activator inhibitor of placental type PAI 2 occurring in amniotic fluid and cord blood . ^^^ Plasminogen activator inhibitor of placental type ( PAI 2 ) occurs in a high molecular weight form ( HMW ) of 60 kd and a low molecular weight form ( LMW ) of 48 kd . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The heparin dependent inhibition of urokinase by this highly purified protein as well as comparison of the kinetic data and amino acid composition of both PCI and the recently described plasminogen activator inhibitor ( PAI ) 3 give high evidence of identity of PCI and PAI 3 . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Different molecular species of interleukin 1 ( IL 1 ) were examined for the spectrum of responses elicited in human endothelial cells ( HEC ) , including synthesis of prostacyclin ( PGI 2 ) , tissue type procoagulant activity ( PCA ) , platelet activating factor ( PAF ) , and plasminogen activator inhibitor ( PA 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Method for the determination of fast acting plasminogen activator inhibitor capacity ( PAI cap ) in plasma , platelets and endothelial cells . ^^^ A titration assay for the determination of the fast acting plasminogen activator inhibitor capacity ( PAI cap ) was developed . ^^^ Most of the hitherto published assays for fast acting PAI are reported to have the disadvantage of non parallel titration curves of tissue plasminogen activator ( t PA ) in buffer and plasma . ^^^ Platelets aggregated by thrombin released plasminogen activator inhibitor amounting to a mean PAI cap of 4 . 33 + / 2 . 98 AU per 2 . 5 10 10 ( 8 ) cells . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A plasminogen activator inhibitor ( PA 1 ) which inhibits primarily plasminogen activator of the urokinase type ( u PA ) was isolated from the cytosol of human peripheral leukocytes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Conditioned medium from cultured bovine aortic endothelial cells contains an inactive plasminogen activator inhibitor ( PAI ) . ^^^ This effect was dose dependent with respect to the particular reagent used , and the same concentration of reagent which induced PAI activity also stimulated the ability of a component in conditioned medium to form sodium dodecyl sulfate stable complexes with exogenously added plasminogen activators . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A functional , immunoradiometric assay for a specific plasminogen activator inhibitor ( PAI ) was developed . ^^^ This assay was based on the ability of the PAI to bind rapidly and strongly to immobilized tissue type plasminogen activator ( tPA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Monospecific antiserum to an unusually stable Mr 50 , 000 plasminogen activator inhibitor ( PAI ) purified from cultured bovine aortic endothelial cells was employed in conjunction with reverse fibrin autography to determine whether human platelets , serum , and plasma contain immunologically related inhibitors . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We assessed coagulation and fibrinolysis activity by evaluation of factor 7 activity , fibrinogen and plasminogen , plasminogen activator inhibitor ( PAI ) , and tissue plasminogen activator antigen basally ( tPA 1 ) and after venous occlusion ( tPA 2 ) . ^^^ Factor 7 ( P < . 001 ) , fibrinogen ( P < . 001 ) , plasminogen ( P < . 001 ) , PAI activity ( P < . 001 ) , tPA 1 ( P < . 02 ) , fasting blood glucose ( P < . 01 ) , apo B ( P < . 02 ) , and immunoreactive insulin ( P < . 01 ) were significantly higher in obese than in lean subjects . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The aim of the present study was to find out whether plasminogen activator inhibitor type 1 ( PAI 1 ) controls the formation of plasmin in patients with ischaemic heart disease . ^^^ We examined PAI activity , PAI 1 antigen , tissue type plasminogen activator ( t PA ) activity , t PA antigen , plasmin alpha 2 antiplasmin complex ( PAP complex ) and fibrin degradation products D dimer in 62 patients before ( unstimulated ) and after infusion of 1 desamino 8 D arginine vasopressin ( DDAVP ; stimulated ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The primary regulatory element of fibrinolytic activity is plasminogen activator inhibitor ( PAI ) . ^^^ We measured the serial changes of PAI activity and tissue plasminogen activator ( TPA ) antigen after rTPA therapy or direct PTCA . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen , plasminogen activator inhibitor 1 ( PAI 1 ) and 2 ( PAI 2 ) , tissue type plasminogen activator ( t PA ) , urokinase ( u PA ) and D dimers ( D D ) were quantified in plasma samples and pleural effusion specimens . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
It is the acute phase reactants such as factor 7 ( F 7 ) , von Willebrand factor ( vWF ) and fibrinogen ( Fbg ) as well as the main inhibitor of the fibrinolytic system , the plasminogen activator inhibitor ( PAI 1 ) , which have been shown to be associated with a particular predisposition or poor prognosis of cardiovascular disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Purification and characterization of the plasminogen activator inhibitors PAI 1 , PAI 2 , and PN 1 from the human glioblastoma U 138 . ^^^ This investigation presents data which indicate that the plasminogen activator inhibitor ( PAI ) activity secreted from U 138 cells is composed of three separate PAIs : PAI 1 , PAI 2 , and PN 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma levels of thrombin antithrombin 3 complex ( TAT ) , D dimer , plasmin ( alpha 2 antiplasmin complex ( PAP ) , tissue type plasminogen activator ( t PA ) antigen and plasminogen activator inhibitor ( PAI ) 1 antigen were followed in twelve patients treated with direct PTCA for AMI . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Levels of tissue plasminogen activator antigen ( t PA : ag ) , tissue plasminogen activator inhibitor 1 antigen ( PAI 1 : ag ) and tissue plasminogen activator inhibitor activity ( PAI activity ) , and alpha 2 antiplasmin ( AAP ) were measured in plasma from 19 patients with severe trauma on admission and on days 1 , 2 , 3 and 7 after the incident . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Pretreatment with L NAME antagonized the LPS induced activation of fibrinolysis as measured by changes in the euglobulin clot lysis time ( ECLT ) and enhanced the LPS induced rise in the plasma level of plasminogen activator inhibitor ( PAI ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We measured the antigen concentrations or activities of plasminogen , tissue type plasminogen activator ( t PA ) , plasminogen activator inhibitor ( PAI ) , alpha 2 antiplasmin , alpha 1 antitrypsin , and alpha 2 macroglobulin as well as total antiplasmin activity and D dimer concentration in the plasma of 39 patients with nephrotic syndrome and 32 normal controls subjects . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
High levels of urokinase in primary tumors are also associated with a poorer prognosis , as well as plasminogen inactivator inhibitor PAI 2 , which plays a crucial role in tumor growth . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We found that plasminogen activator inhibitor type 1 ( PAI 1 ) , the major PAI in plasma , demonstrated concentration dependent inhibition of this solution phase scu PA enzymatic activity . 125I scu PA formed complexes with PAI 1 in a concentration and time dependent manner , as detected by SDS polyacrylamide gel electrophoresis under reducing conditions . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Total cholesterol , HDL cholesterol ( HDL C ) and its subfractions ( HDL 2 C and HDL 3 C ) , blood glucose , Apolipoproteins A 1 and B , fibrinogen , plasminogen , factor 7 , t PA : Ag and PAI activity pre and post venous occlusion ( VO ) were determined . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue type plasminogen activator ( t PA ) and plasminogen activator inhibitor ( PAI ) in transplanted kidneys ] . ^^^ We have studied the involvement of fibrinolysis in acute rejection after kidney transplantation by analyzing changes in urinary levels of substances such as FDP , D dimer , tissue plasminogen activator ( t PA ) and plasminogen activator inhibitor ( PAI ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The effect of nitric oxide donors on the release of plasminogen activator inhibitor ( PAI ) from rabbit platelets in vitro . ^^^ Here we describe effects of four nitric oxide ( NO ) donors , 4 arylsubstituted oxatriazol derivatives and 3 morpholino sydnonimine ( SIN 1 ) at concentrations of 30 1000 microM on the release of plasminogen activator inhibitor ( PAI ) from rabbit platelets in vitro . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Increased expression of plasminogen activator inhibitor 1 ( PAI 1 ) has been demonstrated in the human atherosclerotic vessel wall and may contribute to the impaired plasma fibrinolytic capacity in patients at high risk of atherothrombotic events . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
For each sample the determination of seven prothrombotic markers [ ( fibrinogen ( F ) , factor 7 ( F 7 ) , antithrombin 3 ( AT 3 ) , protein C ( PC ) , protein S ( PS ) ( coagulometric method IL ) , tissue plasminogen activator ( t PA ) , plasminogen activator inhibitor ( PAI 1 ) ( ELISA method Boehringer ) ] and of three prethrombotic markers [ ( fibrinopeptide A ( FPA ) , beta thromboglobulin ( BTG ) and D dimer ( D D ) ( ELISA method , Boehringer ) ] was performed . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Significant differences ( P < 0 . 03 ) in plasminogen activator inhibitor ( PAI ) and functional antithrombin 3 levels were also noted . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The effect of aspirin or endotoxin or aspirin plus endotoxin on the circadian variations of plasminogen activator activity ( PAA ) , tissue type plasminogen activator ( t PA ) antigen level , plasminogen activator inhibition ( PAI ) and plasmin inhibition ( PI ) in aorta , heart and brain of the rat was studied . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Because an elevation of plasminogen activator inhibitor ( PAI ) 1 increases procoagulant activity , we have determined whether plasma PAI activity and tissue PAI 1 mRNA are elevated after hemorrhage . ^^^ Plasma PAI activity was determined by the capacity of plasma to inhibit tissue type plasminogen activator activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
PATIENTS AND METHODS : In a consecutive series of 203 patients resected for primary gastric cancer , the expression of uPA , uPA receptor ( uPA R ) , plasminogen activator inhibitor ( PAI ) 1 , and PAI 2 was determined immunohistochemically . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We determined : total cholesterol , triglycerides , HDL cholesterol , blood glucose , Apolipoproteins A 1 and B , insulin , Lp ( a ) , Factor 7 , fibrinogen , plasminogen , t PA ( Ag ) pre and post venous occlusion ( VO ) and PAI activity pre and post VO . ^^^ In addition to metabolic abnormalities obese non diabetic subjects and lean and obese NIDDM patients displayed significantly higher levels of fibrinogen , Factor 7 , plasminogen , PAI pre and post VO and tPA ( Ag ) pre VO and significantly lower levels of t PA ( Ag ) post VO . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A possible prothrombotic role for the angiotensin system has been postulated , and support for this has been provided by a recent study that demonstrated that an infusion of angiotensin increases levels of the prothrombotic plasminogen activator inhibitor ( PAI ) . ^^^ In the current study the authors have investigated the effect of two ACE inhibitors , captopril and enalapril , on tissue plasminogen activator ( tPA ) and PAI in 33 congestive heart failure ( CHF ) patients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Specific inhibitors have been identified for most of the proteolytic enzymes , e . g . plasminogen activator inhibitors ( PAI ' s ) and tissue inhibitors of metalloproteinases ( TIMP ' s ) . ^^^ This review focuses on plasminogen inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The relevance of urokinase type plasminogen activator ( uPA ) and plasminogen activator inhibitor ( PAI ) type 1 in predicting the survival probability of patients with advanced ovarian cancer after radical surgery and adjuvant chemotherapy by assessing the patients ' primary tumors has recently been shown by us ( W . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Resting and post venous occlusion euglobulin clot lysis time , tissue type plasminogen activator ( t PA ) activity , t PA antigen , plasminogen activator inhibitor ( PAI ) activity and plasminogen activator inhibitor type 1 ( PAI 1 ) antigen determined on the two occasions did not differ significantly . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In this population based case control study , we examined the relationship between the fibrinolytic variables tissue plasminogen activator ( t PA ) antigen and plasminogen activator inhibitor ( PAI ) activity , cardiovascular risk factors and peripheral arterial disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The aim of the present study was to investigate the influence of isotretinoin upon fibrinolysis , and more specifically upon tissue plasminogen activator ( tPA ) and tissue plasminogen activator inhibitor ( PAI ) levels , in haemostatically normal individuals . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
STUDY OBJECTIVE : To compare the expression of plasminogen activators ( PA ) and plasminogen activator inhibitors ( PAI ) in normal lung mucosa and lung carcinomas . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Several tissues were also observed to constitutively secrete a plasminogen activator inhibitor which was detected in the form of a PA PAI complex . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
No significant difference was found in plasma plasminogen activator inhibitor ( PAI ) activity in the two groups . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fibrin degradation is plasmin dependent and is regulated by the balance between plasminogen activators ( PA ) , tissue PA ( t PA ) , urokinase PA ( u PA ) , and their inhibitors ( PAI ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Since the plasminogen activator [ PA / plasminogen activator inhibitor ( PAI ) system is believed to be involved in a breakdown of articular cartilage in osteoarthritis ( OA ) , we studied the modulation of single components of the fibrinolytic system ( urokinase type plasminogen activator , u PA ; plasminogen activator inhibitor 1 , PAI 1 ; the surface receptor for u PA , u PAR ) in human chondrocytes in the presence of piroxicam . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To evaluate the effects of lipoprotein ( a ) [ Lp ( a ) ] on the fibrinolytic system in patients with acute myocardial infarction ( AMI ) who underwent thrombolytic therapy with recombinant tissue type plasminogen activator , we examined serial changes in plasma levels of Lp ( a ) , plasminogen activator inhibitor ( PAI ) activity , alpha 2 plasmin inhibitor plasmin complex ( PIC ) and thrombin antithrombin 3 complex ( TAT ) in venous plasma samples from 25 patients with AMI for 3 weeks . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The following parameters were assayed in arterial blood samples obtained before and after the examination in each patient : platelet markers : beta thromboglobulin ( beta TG ) and platelet factor 4 ( PF 4 ) ; prethrombotic markers : thrombin antithrombin 3 complex ( TAT ) and prothrombin fragments 1 and 2 ( F 1 + 2 ) as well as partial exploration of fibrinolysis : tissue plasminogen activator inhibitors ( PAI ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In five patients with idiopathic osteonecrosis ( ON ) of the hip , four having hypofibrinolysis mediated by high plasminogen activator inhibitor ( PAI Fx ) , and one with high Lp ( a ) , our specific aim was to determine whether therapy ( Rx ) with the anabolic androgenic steroid , Stanozolol ( 6 mg / day ) , would normalize PAI Fx and Lp ( a ) and thus potentially ameliorate ON . ^^^ Prior to Rx , none of the four patients with high PAI Fx could normally elevate tissue plasminogen activator ( tPA Fx ) after 10 min venous occlusion at 100 mm Hg . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Chromogenic peptide substrate analytical method was used to detect plasma tissue plasminogen activator ( t PA ) , tissue plasminogen activator inhibitor ( PAI ) activity and ratio of P / t . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fibrinolytic activity was estimated as the fast acting inhibitor against tissue plasminogen activator usually termed PAI 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue type plasminogen activator ( t PA ) antigen , plasminogen activator inhibitor ( PAI ) activity , and von Willebrand factor antigen ( vWF : Ag ) and activity ( vWF : RCof ) were measured in 21 SLE patients ( 12 of whom were therapy free ) and 22 controls . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The objective of the present study was to assess the effect of EPO in dialyzed patients on two key enzymes of fibrinolysis , i . e . the tissue activator of plasminogen ( t PA ) and the inhibitor of the plasminogen activator ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
From a cross sectional population sample of 1558 men and women aged 25 to 64 years , plasma fibrinogen , tPA activity and plasminogen activator inhibitor 1 ( PAI ) activity were determined using specific assays . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Animals infected with DR ' 78 virus , in contrast , showed an inhibition of fibrinolysis in the late stages of disease with almost a 5 fold increase of plasminogen activator inhibitor ( PAI ) activity of 196 . 0 AU / ml . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is the major inhibitor for plasmin formation promoted by tissue and urokinase plasminogen activators . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue plasminogen activator ( tPA ) and plasminogen activator inhibitor ( PAI ) were determined before and after VOT . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In all the patients , prolonged euglobulin lysis time , increased plasminogen activator ( PA ) and plasminogen activator inhibitor ( PAI ) activities before and after a venous occlusion test were detected and indicated an inhibition of fibrinolysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor ( PAI ) activity was positively related to LDL . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma levels of fibrinogen , tissue plasminogen activator ( t PA ) and plasminogen activator inhibitor ( PAI ) activity were measured at 3 month intervals . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The relationships between plasminogen activator inhibitor ( PAi ) activity and lipoprotein ( a ) [ Lp ( a ) ] and insulin , testosterone , 17 beta estradiol , and testosterone binding globulin ( TEBG ) were assessed in 42 myocardial infarction male patients and 74 healthy controls . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In addition plasma levels of plasminogen activator inhibitor 1 ( PA 1 ) are greatly increased , multiple organ failure is a major clinical manifestation in advanced cases and sepsis is a representative underlying disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The influence of acute bouts of dynamic exercise on plasma tissue plasminogen activator ( tPA ) , plasminogen activator inhibitor ( PAI ) and fibrinogen was investigated on nine healthy non smoking men aged 23 to 37 years . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The logarithm of the initial plasma levels of tumor necrosis factor ( TNF ) alpha , interleukin ( IL ) 1 beta , IL 6 , IL 1 receptor antagonist ( ra ) , and plasminogen activator inhibitor ( PAI ) 1 correlated significantly with APACHE 2 scores ( r 2 = . 67 , . 57 , . 68 , . 81 , and . 68 , respectively ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Thirty two percent were found to have prolongation of the postvenous occlusion euglobulin clot lysis time ( PVO ELT ) , 32 % were found to have elevated levels of plasminogen activator inhibitor 1 ( PAI ) and 66 % were found to have reduced release of tissue plasminogen activator ( tPA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Increased tissue plasminogen activator ( t PA : Ag ) antigen 4 hours after AraC application ( p < 0 . 05 ) as well as increased levels of plasminogen activator inhibitor activity ( PAI ) ( p < 0 . 05 ) and fibrinopeptide A ( FPA ) antigen ( p < 0 . 05 ) were observed on day 2 . ^^^ During that period of infection the increased levels of FPA on day 21 ( p < 0 . 05 ) , PAI on days 15 and 21 ( p < 0 . 05 ) and fibrinogen on day 21 ( p < 0 . 05 ) as well as decreased values of antithrombin 3 ( p < 0 . 05 ) on day 21 and protein C on day 15 ( p < 0 . 05 ) were measured . t PA : Ag , plasminogen , alpha 2 antiplasmin and fibrin ( ogen ) degradation products were within normal throughout infectious complications . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
After 9 10 weeks of treatment , the plasma fibronectin ( Fn ) level and Plasminogen activator inhibiter ( PAI ) value were found significantly lower ( P < 0 . 05 ) in the rhubarb treated group than in the placebo . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We measured plasminogen activator inhibitor ( PAI ) activity in the plasma of 81 children with diarrhoea associated ( D+ ) HUS , and found elevated PAI activity in many patients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Heat stroke patients showed ( 1 ) significant prolongation of the prothrombin ( PT ) , activated partial thromboplastin ( aPTT ) and thrombin times ( TT ) but normal reptilase time ( RT ) ; ( 2 ) significant reduction in plasma levels of antithrombin 3 ( AT 3 ) , factor 5 , proteins C and S , plasminogen activator inhibitor ( PAI ) and platelet count ; ( 3 ) increase in plasma factor 8 , tissue plasminogen activator ( t PA ) and serum FDP ; ( 4 ) no significant changes in plasma fibrinogen , plasminogen , alpha 2 antiplasmin and factors 7 and 10 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma levels of thrombin antithrombin 3 complex ( TAT ) , plasmin alpha 2 plasmin inhibitor complex ( PIC ) and active plasminogen activator inhibitor ( PAI ) were assayed in 66 cases of disseminated intravascular coagulation ( DIC ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Serial determinations of thrombin antithrombin 3 complex ( TAT ) , plasminogen activator inhibitor ( PAI ) , and D dimer were made in pleural fluid samples taken at the beginning of thoracoscopy ( baseline ) , immediately after thoracoscopic biopsies had been done ( postbiopsy ) , 3 h after thoracoscopy either with talc poudrage or without and 24 and 48 h after the procedure , as well as in cases of recurrence of effusions ( farline ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The antigen levels of urokinase type plasminogen activator ( uPA ) and its inhibitor plasminogen activator inhibitor ( PAI ) 1 , as detected in tumor extracts by ELISA , have been reported to be correlated with a poor prognosis in primary breast cancer . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In this report , AVP induced expression of plasminogen activator inhibitor ( PAI ) 2 mRNA in rat microvessel endothelial ( RME ) cells was identified using differential mRNA display . ^^^ These findings suggest that AII may regulate plasminogen activation in the vasculature by inducing both PAI 1 and PAI 2 expression . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A mutant recombinant plasminogen activator inhibitor 1 ( PAI 1 ) was created ( Ser 338 > Cys ) in which cysteine was placed at the P 9 position of the reactive center loop . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitors ( PAI 1 and PAI 2 ) were found only focally in approximately 10 per cent of the lesions . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma plasminogen activator inhibitor 1 ( PAI ) antigen , fibrinogen , antithrombin 3 ( ATIII ) , protein C , beta thromboglobulin ( BTG ) , platelet count , fibrinogen degradation product ( FDP ) D dimer , factors 7 and 12 , as well as cholesterol , triglyceride ( TG ) and glucose were determined in 163 subjects . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The relationship between plasma Lipoprotein ( a ) ( Lp ( a ) ) levels and plasminogen activator inhibitor ( PAI ) activity and tissue plasminogen activator ( t PA ) antigen levels were studied in 15 patients with unstable angina . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Single chain u PA ( scu PA ) was recently found to efficiently initiate cell surface plasminogen activation , and we herein describe the interaction of scu PA with PAI type 2 ( PAI 2 ) . ^^^ In the fluid phase ( no cells ) the plasminogen activating activities of both scu PA and Glu 158 scu PA ( a plasmin non activatable variant of scu PA ) were inhibited in a concentration dependent manner by recombinant human PAI 2 . ^^^ These data suggest that the initiation of cell surface plasminogen activation may involve the partitioning of scu PA between PAI 2 ( a `` negative modulator ' ' ) and the u PA receptor ( a `` positive modulator ' ' ) and that the enzymatic activity of receptor bound scu PA may allow initiation of cell surface proteolysis even in PAI 2 rich environments . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The activities of tissue plasminogen activator ( tPA ) and plasminogen activator inhibitor ( PAI ) were measured in the peritoneal fluid of rats with faecal peritonitis and correlated with the extent of peritoneal damage to determine the cause of decreased fibrinolysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The activity of uPA on the cell surface appears to be a function of the number of uPA specific receptors ( uPAR ) and the extent of inhibition of uPA by plasminogen activator inhibitors ( PAI ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We compared the response of the t PA plasminogen activator inhibitor type 1 ( PAI 1 ) fibrinolytic system in patients with preinfusion levels of active t PA below or at the detection limit of the assay with that in patients with higher preinfusion levels of active t PA . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Concentrations of tissue plasminogen activator ( t PA ) and plasminogen activator inhibitor ( PAI ) were measured in blood obtained from pregnant women to elucidate the fluctuations in the fibrinolytic system which occur during the course of pregnancy . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The main outcome measures were plasma fatty acids and potential risk factors for cardiovascular disease ( age , sex , smoking , blood pressure , serum cholesterol , HDL cholesterol ( HDL C ) , triglycerides ( TGs ) , lipid peroxides ( LPx ) , plasma fibrinogen , von Willebrand factor ( vWf ) , beta thromboglobulin ( beta TG ) , cross linked fibrin degradation products ( FIBDP ) and plasminogen activator inhibitor PAI ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We evaluated the capacity of peripheral blood mononuclear cells to produce procoagulant activity ( PCA ) and plasminogen activator inhibitor ( PAI ) in 12 children with newly diagnosed lymphoma ( 8 non Hodgkin ' s , 4 Hodgkin ' s ) and in 12 matched healthy donors . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The antigen levels of von Willebrand factor ( vWF ) , tissue plasminogen activator ( t PA ) , and its inhibitor ( PAI ) were also determined as markers of release from the endothelium , while the fragment 1 + 2 of prothrombin ( F 1 + 2 ) and thrombin antithrombin 3 ( TAT ) complexes were assessed as indexes of systemic thrombin generation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
All the haemostatic ( figrinogen , Factor 7 , plasminogen activator inhibitor ( PAI ) activity and tissue plasminogen activator ( t PA ) antigen ( Ag ) pre venous occlusion ( VO ) ) and haemorheological parameters ( haematocrit , whole blood filterability , blood and plasma viscosity ) were significantly higher in the abdominal obesity group as compared to the control group . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A significant decrease in plasminogen activator type 2 ( PAI 2 ) and urokinase levels in plasma and amniotic fluid was observed in IUGR groups in comparison with normal pregnancy . ^^^ No significant differences were observed between the control and IUGR groups in relation to the other fibrinolytic parameters , except for plasma PAI type 1 and tissue type plasminogen activator levels , which were significantly increased in the PE group . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The aim of the present study was to evaluate fibrinolysis at the level of plasminogen activation under conditions of a dynamic test , using methods which reflect sensitively and specifically the activity of the tissue type plasminogen activator ( t PA ) and the activity of the inhibitor of the tissue type plasminogen activator ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To determine the behaviour of the coagulation variables antithrombin 3 ( ATIII ) , protein C , thrombin / antithrombin 3 ( TATIII ) ; fibrinolytic activity , tissue plasminogen activator antigen ( t PA ) , plasminogen activator inhibitors ( PAI ) 1 and 2 , and endothelial involvement by fibronectin assay in normal and pre eclamptic pregnancies . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Platelet derived growth factor ( PDGF ) , a mitogen recently shown to increase plasminogen activator inhibitor type 1 ( PAI 1 ) synthesis in VSM cells , shares with angiotensin 2 ( Ang 2 ) several steps of its intracellular signaling pathway . ^^^ METHODS AND RESULTS : The expression of PAI 1 and tissue type plasminogen activator ( TPA ) mRNA in cultured rat VSM cells was studied . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Furthermore , CE decreased plasminogen activator inhibitor ( PAI ) and the thrombin antithrombin complexes ( TAT ) , as well as antithrombin ( ATIII ) . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In this study , cervical spinal cord irradiation was studied in 90 rats by measuring plasminogen activator inhibitor ( PAI ) 1 on Days 2 , 7 , 30 , 60 , 90 , 120 , 130 , or 145 after irradiation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The aim of this study was to investigate , in this high risk population , whether unstable angina was associated with abnormalities of tissue type plasminogen activator ( t PA ) or plasminogen activator inhibitor ( PAI ) activities and whether , in a prospective study , any of these parameters would identify patients with an adverse cardiovascular prognosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The markers for hemostasis and fibrinolysis were : markers for plasmin generation [ alpha 2 plasmin inhibitor ( alpha 2 PI ) , plasminogen , plasmin alpha 2 PI complex ( PIC ) ] ; markers for fibrinolysis [ fibrin / fibrinogen degradation products E fragment ( FDP E ) , FDP D D dimer ( D dimer ) , fibrinogen ] ; markers for hemostatic activity ( prothrombin time ( PT ) , antithrombin 3 ( AT 3 ) , protein C ) ; markers for thrombin generation [ thrombin antithrombin 3 complex ( TAT ) ] ; markers for intrinsic fibrinolytic activity [ tissue plasminogen activator plasminogen activator inhibitor complex ( TPA PAI complex ) ] . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma levels of tissue type plasminogen activator antigen ( t PA : Ag ) , plasminogen activator inhibitor 1 antigen ( PAI 1 : Ag ) , the active form of PAI 1 ( active PAI ) and t PA . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator ( PA ) and PA inhibitor ( PAI ) antigen , activity , and mRNA were analyzed in the three layers of rat aorta , and the effect of endotoxin on PA and PAI was studied . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The productions of gelatinases A and B ( 72 kDa and 92 kDa type 4 collagenases ) and their inhibitors ( TIMP 1 and TIMP 2 ) , plasminogen activators ( PAs ) and plasminogen activator inhibitors ( PAI ) were investigated . ^^^ The B 16 cell lines did not secrete any gelatinase , but they secreted TIMP 2 , tissue type ( t PA ) , urokinase type ( u PA ) plasminogen activators and PAI 1 like activities . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The expression of tissue factor ( TF ) and plasminogen activator inhibitor ( PAI ) 1 was induced in cultured human umbilical vein cells ( HUVEC ) by very low density lipoprotein ( VLDL ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To screen for risk of embolism , we investigated the association between the presence of left atrial ( LA ) thrombus by transesophageal echocardiography ( TEE ) and blood coagulation tests , including thrombin antithrombin 3 complex ( TAT ) , plasminogen activator inhibitor 1 ( PAI 1 ) , plasmin alpha 2 plasmin inhibitor complex ( PIC ) , D dimer , tissue plasminogen activator ( tPA ) , free tPA , tPA . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To examine whether the coagulation and fibrinolytic systems are altered in such ischemic heart diseases , the plasma levels of fibrinopeptide A ( FPA ) and plasminogen activator ( PAI ) were measured . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We performed three extractions : on day one , day five and following the withdrawal of the fat emulsion , with study of modifications to antithrombin 3 , alpha 2 antiplasmin , plasminogen , C protein , plasminogen tissular activator ( t PA ) , plasminogen tissular activator inhibitor ( PAI 1 ) , fibrinogen , and fibrinogen / fibrin degradation products . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
However , lysis of the model platelet rich thrombus did proceed some 30 % more quickly when treated with a plasminogen activator inhibitor ( PAI ) resistant t PA variant . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Mean levels ( m + / sd ) of plasma fibrinogen , factor 7 coagulant activity and plasminogen activator inhibitor ( PAI ) were significantly higher in postmenopausal women not taking HRT ( n = 99 ) than in premenopausal women ( n = 139 ) within the same decade ( 319 + / 52 mg / dl vs 304 + / 60 mg / dl , 107 + / 17 % vs 96 + / 16 % , 9 . 73 + / 5 . 71 U / ml vs 7 . 61 + / 4 . 36 U / ml respectively ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The role of plasminogen activator inhibitor type 1 ( PAI 1 ) in the clearance of tissue type plasminogen activator ( t PA ) by hepatocyte like cells was studied . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In order to assess the influence of oral aspirin ( 165 mg / day ) and intravenous infusion of heparin ( 1000 U / h ) on fibrinolysis in unstable angina we determined plasminogen activator inhibitor ( PAI ) activity and plasma contents of fibrinogen , antithrombin 3 , protein C on admission and on day 3 of treatment in a subgroup of 51 patients ( 25 aspirin , 26 heparin ) from double blind randomized comparative trial of aspirin and i . v . heparin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
However , the inhibitor constant of PEG PPG UK for plasminogen activator inhibitor 1 ( PAI 1 ) was equal to that of UK . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Alpha 2 antiplasmin ( alpha 2AP ) , antithrombin 3 ( AT 3 ) , C 1 esterase inhibitor ( C 1 INH ) , plasminogen activator inhibitor ( PAI ) activities , alpha 2macroglobulin ( alpha 2M ) , fibrinogen , fibrin monomers concentration and euglobulin clot lysis time ( ECLT ) were measured before and after 1 , 2 , 4 , 8 and 12 weeks of rHEPO therapy . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In order to study the analytical performance of different commercial kits for determination of plasminogen activator inhibitor ( PAI ) activity we distributed eight selected split samples to 11 European laboratories experienced with haemostasis testing . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Multicenter evaluation of commercially available methods for the immunological determination of plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS Plasminogen activator inhibitor ( PAI ) activity and concentrations of tissue plasminogen activator ( t PA ) antigen were measured in venous plasma samples taken at 2200 , 0600 , and 1400 and 24 h Holter tapes were recorded in 15 patients with variant angina , 12 patients with stable exertional angina , and 12 controls . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor ( PAI ) in obese men and obese women . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 Ag ) levels were raised in group 2 ( 28 . 0 IU / ml ) versus controls ( 8 . 5 IU / ml ) but PAI activity was similar in all groups . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Effects of Guan Mai Shu ( GMS ) , a traditional Chinese medicine preparation , on tissue type plasminogen activator ( t PA ) and plasminogen activator inhibitor ( PAI ) in the plasma of patients with coronary heart disease were studied . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In 30 patients with osteonecrosis of the hip ( 12 idiopathic , 18 secondary ) , we assessed the role of hypofibrinolysis mediated by high levels of plasminogen activator inhibitor ( PAI ) . ^^^ Nine of the 12 patients with idiopathic osteonecrosis had exceptionally high PAI levels and could not normally elevate tissue plasminogen activator ( tPA Fx ) , the major stimulator of fibrinolysis , after 10 min of venous occlusion at 100 mm Hg . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The high uPA activity was counteracted both in the growth medium and at the cell surface by an increased plasminogen activator inhibitor ( PAI ) production and reduction of uPA synthesis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fibrinogen ( Fg ) , plasminogen ( Plg ) , alpha 2 antiplasmin ( alpha 2 AP ) , plasminogen activator ( PA ) , tissue plasminogen activator ( tPA ) , plasminogen activator inhibitor ( PAI ) , D dimer ( DD ) and fibrin ( ogen ) degradation products ( FDP ) were studied in 60 subjects : 40 patients with endemic hepatosplenomegaly ( 20 during acute haematemesis from ruptured oesophageal varices , 20 with endemic hepatosplenomegaly assigned to the same grade of oesophageal varices but with no history of haematemesis ) and 20 normal controls . ^^^ Reduced levels of Fg , Plg , alpha 2 AP and PAI were associated with increasing levels of PA , t PA , DD and FDP . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Human mesothelial cells synthesize plasminogen activator inhibitor ( PAI ) 1 in inflamed peritoneal tissue . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Effect of isotretinoin on endogenous tissue type plasminogen activator ( t PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) in humans . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue type plasminogen activator ( t PA ) and plasminogen activator inhibitor ( PAI ) ] . ^^^ Tissue type plasminogen activator ( t PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) are the most important factors involved in the regulation of blood fibrinolysis . t PA converts zymogen plasminogen to plasmin on the surface of endothelial cells to maintain blood fluidity and on the surface of the thrombus to efficiently lyse the thrombus . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The fibrinolytic inhibitor , plasminogen activator inhibitor ( PAI ) , levels were elevated throughout . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Familial hypofibrinolysis with 3 generation , autosomal dominant , very high levels of plasminogen activator inhibitor activity ( PAI Fx ) and antigen ( PAI Ag ) was etiologically associated with bilateral idiopathic osteonecrosis in 2 brothers . ^^^ They , their mother , 2 brothers , sister , and all 4 of her children ( none of whom had yet developed osteonecrosis ) , all had very high PAI and could not elevate tissue plasminogen activator after 10 minutes of venous occlusion at 100 mmHg . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Secreted plasminogen activator inhibitor ( PAI ) bioactivity and PAI type 2 antigen levels were significantly increased following exposure of monocytes to DD . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator activity ( PAA ) , tissue type PA ( t PA ) antigen level , plasminogen activator inhibition ( PAI ) , and plasmin inhibition ( PI ) showed no sex dependent differences in the stomach of the rat . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We measured PT , TT , KPTT , Fg , vWF , AT IIIAg , AT IIIA , alpha 2M , TXB 2 , 6 keto PGF 1 alpha , PLg , tPAAg , tPAA and PAI of patients with acute onset of chronic bronchitis , pulmonary emphysema , and cor pulmonale . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
TGF beta increased in a dose dependent manner the production of plasminogen activator inhibitor 1 ( PAI 1 ) in cultured human synovial fibroblast like cells , as measured by ELISA . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Twenty one of the 56 had high plasma levels of type 1 plasminogen activator inactivator ( PAI 1 ) as well as a high PAI activity level ( p < 0 . 001 for comparison with normal controls ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
These haemodynamic responses are associated with increments in the plasma levels of renin , noradrenaline ( NA ) , clotting factor 8 ( FVIII : C ) , von Willebrand factor ( vWF : ag ) , and tissue type plasminogen activator ( t PA ) , and a fall in the plasma level of plasminogen activator inhibitor ( PAI ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The tissue plasminogen activator ( tPA ) , plasminogen activator inhibitor ( PAI ) and euglobulin lysis time ( ELT ) were measured before and after VOT . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Expression of plasminogen activators ( PA ) , tissue type ( t PA ) and urokinase type ( u PA ) , as well as PA inhibitors ( PAI ) , type 1 ( PAI 1 ) and type 2 ( PAI 2 ) , were investigated immunohistochemically in 97 human pancreatic carcinomas . u PA expression predominated in pancreatic carcinomas , compared with t PA [ u PA expression in 76 specimens ( 78 . 4 % ) and t PA in eight specimens ( 8 . 2 % ) ] . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma levels of tissue plasminogen activator antigen ( t PA Ag ) , plasminogen activator inhibitor ( PAI ) activity , and factor 8 von Willebrand factor ( vWF ) were measured before and 10 minutes after venous occlusion . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The fibrinolytic capacity of blood depends mainly on the amount of tissue type plasminogen activator ( t PA ) activity and plasminogen activator inhibitor type 1 ( PAI 1 ) activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue plasminogen activator activity increased ( p < 0 . 01 ) and its inhibitor ( PAI ) activity decreased ( p < 0 . 001 ) after desmopressin infusion . ^^^ A correlation between the fall in platelet serotonin content and changes in tissue plasminogen activator and PAI activities was found ( r = 0 . 55 , p < 0 . 01 respectively ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The levels of plasma tissue type plasminogen activator ( tPA ) , plasminogen activator inhibitor ( PAI ) , 8 factor related antigen ( VIIIR : Ag ) and anti thrombin ( AT 3 ) were determined in 40 hypertensive patients with Blood Stasis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Factor 8 coagulant activity ( VIIIc ) , von Willebrand factor ( vWf : Ag ) , von Willebrand factor activity ( vWf : RCo ) , tissue plasminogen activator antigen ( tPA ) and plasminogen activator inhibitor activity ( PAI ) was monitored before and after correction of hypothyroidism by hormone supplementation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In order to elucidate if this decreased response is due to an increase in plasminogen activator inhibitors 1 and 2 ( PAI 1 , PAI 2 ) , and / or to decreased release of tissue type plasminogen activator ( t PA ) antigen during venous occlusion , 36 women ( 18 women with normal pregnancy and 18 with gestational hypertension without proteinuria ) were followed during pregnancy and puerperium . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
E . ( 1991 ) Nature 353 , 576 578 ) and resembling the latent form of plasminogen activator inhibitor ( PAI ) ( Mottonen , J . , Strand , A . , Symersky , J . , Sweet , R . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Specificity of antigen assays of plasminogen activator inhibitor in plasma : Innotest PAI 1 immunoassay evaluated . ^^^ We evaluate a new commercial enzyme immunoassay ( EIA ) of plasminogen activator inhibitor 1 ( PAI 1 ) in plasma , the Innotest PAI 1 . ^^^ The recovery of the different molecular forms of PAI 1 , relative to active PAI 1 ( 100 % ) , was 99 % + / 7 % for PAI 1 complexed with recombinant tissue type plasminogen activator ( t PA ) , 104 % + / 4 % for PAI 1 complexed with melanoma t PA , 94 % + / 11 % for PAI 1 complexed with high M ( r ) urokinase , and 113 % + / 3 % for latent PAI 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the attempt to better characterize the PA / plasminogen system in the human ovary , we examined PA and PA inhibitor ( PAI ) production in cultures of granulosa cells obtained from normally cycling untreated women at different stages of the cycle . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The following parameters of fibrinolytic activity were measured initially ( t 0 ) , at the end of the aerobic phase ( t 1 ) , at the end of the anaerobic phase ( t 2 ) and after a 30 min recovery period ( t 3 ) : tissue plasminogen activator ( PAt ) activity , PAt concentration , plasminogen activator ( PAt ) activity , PAt concentration , plasminogen activator inhibitor ( PAi ) activity , and D Dimer concentration . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In this study , we determined the plasma levels of tissue plasminogen activator ( tPA ) , plasminogen activator inhibitor ( PAI ) , urokinase plasminogen activator ( uPA ) , and von Willebrand factor ( vWF ) antigen in Blackfoot disease patients , in comparison with normal controls from non endemic areas and the endemic area , Putai . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In contrast , plasminogen activator inhibitor 1 ( PAI 1 ) antigen levels , measured by a double antibody enzyme linked immunosorbent assay , were significantly increased in culture media ( CM ) on cathepsin G ( 1 microgram / ml ) treatment after 15 minutes ( 5 . 1 + / 1 . 2 ng / ml vs 2 . 6 + / 0 . 6 ng / ml for controls , p < 0 . 01 ) and 6 hours of incubation ( 69 . 6 + / 17 . 5 ng / ml vs 40 . 0 + / 9 . 0 ng / ml for controls , p < 0 . 01 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue plasminogen activator ( t PA ) , t PA antigen , plasminogen activator inhibitor ( PAI ) , plasminogen ( PL ) and alpha 2 antiplasmin ( AP ) were measured in 10 uremic patients on maintenance hemodialysis treated sequentially with Cuprophane and polyacrylonitrile ( AN 69 ) membranes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have measured various fibrinolytic and coagulation parameters ( t PA antigen , PAI , fibrinogen , plasminogen and factor 7 ) before and after 10 min of venous occlusion in 20 hypertryglyceridaemic subjects ( twelve males and eight females , age 38 + / 4 years , body mass index 23 + / 1 . 5 ) and 20 healthy normal subjects , matched for sex ( twelve males and eight females ) , age ( 37 + / 3 . 5 years ) and body mass index ( 22 . 8 + / 1 . 4 ) . ^^^ At rest , t PA : Ag , PAI , fibrinogen , plasminogen and factor 7 were significantly ( P < 0 . 005 ) higher in hypertriglyceridaemic subjects than in normal controls . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This difference was largely due to cell surface turnover of active uPA complexed with plasminogen activator inhibitor ( PAI ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Blood samples for determination of factor 7 clotting activity using human ( FVIIc ) and bovine thromboplastin ( FVIIbt ) , and for assessment of factor 7 antigen ( FVIIag ) , tissue plasminogen activator ( t PA ) antigen , plasminogen activator inhibitor 1 ( PAI 1 ) antigen , PAI activity , t PA and euglobulin fibrinolytic activity , and triglyceride and insulin levels were collected regularly on the second day of each diet period . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Elevated plasma levels of fibrinogen , factor 7 coagulant activity ( F VIIc ) , and plasminogen activator inhibitor ( PAI 1 ) have been reported to be strictly associated with thrombotic events and are considered to be important risk markers of atherothrombotic cardiovascular disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To evaluate the drug ' s influence on the coagulation and fibrinolytic systems , von Willebrand factor ( vWF ) , the activities of tissue plasminogen activator ( tPA ) and plasminogen activator inhibitor ( PAI 1 ) , and the split products of cross linked fibrin ( D dimers ) were investigated . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) , which is secreted from vascular endothelial cells , plays an important role in regulating fibrinolysis . ^^^ We measured the plasma concentrations of tissue type plasminogen activator ( t PA ) , PAI 1 and t PA PAI complex before and serially after thrombolytic therapy for acute myocardial infarction to clarify the relationship between thrombolytic therapy and PAI 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Moreover , purified TGF beta 1 produces a Schwann cell morphology alteration and decreases the secretion of tissue type plasminogen activator ( tPA ) and enhances the secretion of plasminogen activator inhibitor ( PAI ) by Schwann cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Extracts of skin tissues cultured for 4 days with penicillamine , captopril or thiopronine were assayed for the presence of plasminogen activator ( PA ) and plasminogen activator inhibitors ( PAI ) on agar fibrin plates . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Inflammation reduces peritoneal plasminogen activating activity and leads to the appearance of plasminogen activator inhibitor ( PAI ) type 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Epidermal growth factor ( EGF ) , a paracrine hormone found in the human ovary , increases plasminogen activator ( PA ) activity and the gene expression of PA and plasminogen activator inhibitor ( PAI ) in human endothelial cells and human cell lines . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator ( PA ) and PA inhibitor ( PAI ) were measured in homogenates of leukemia cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The plasminogen activator ( PA ) / plasminogen activator inhibitor ( PAI ) system is believed to be involved in connective tissue remodelling in joint disease and both PA and PAI production has been shown in several cell types in the joint . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator and PAI . ^^^ The quantities of t PA Ag and plasminogen activator inhibitor ( PAI ) Ag were determined by using enzyme linked immunosorbent assays . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have monitored the individual changes of plasminogen activator ( PA ) and plasminogen activator inhibitor ( PAI ) activities of cellular lysates and secretions of these macrophages , after they were stimulated by various exogenous agents . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
These fibroblasts also produced and secreted low levels of a plasminogen activator inhibitor ( PAI ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
No significant changes in PAI ( Plasminogen Activator Inhibitor ) activity and fibrinogen levels were recorded . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator activity ( PAA ) and plasminogen activator inhibition ( PAI ) , against t PA ( t PAI ) or u PA ( u PAI ) , in spermatozoa and seminal plasma as well as testosterone in the blood of Friesland , Chios , and Karagouniki rams all showed a seasonal variation with the highest values during the corresponding breeding season of the ewes ( Autumn Winter ) . ^^^ Plasminogen activator activity and PAI in seminal plasma also showed similar seasonal variations . ^^^ Plasminogen activator activity and PAI in spermatozoa and seminal plasma showed a positive correlation with blood testosterone . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI ) activity , plasma insulin , glucose , cholesterol and triglyceride ( TG ) concentrations were determined in 32 Chinese diabetic patients ( mean age 61 . 4 yr ) and 41 healthy controls ( mean age 64 . 5 yr ) to establish the relationships between these parameters . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The blood was enzymatically analyzed for lactic acid ( LA ) and assayed using chromogenic substrates for the determination of tissue plasminogen activator ( t PA ) , plasminogen activator inhibitor ( PAI ) , and Factor 8 ( FVIII ) activities . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator activity ( PAA ) , t PA antigen level , plasminogen activator inhibition ( PAI ) and plasmin inhibition ( PI ) showed a circadian variation in rat aorta , heart , brain , and lungs of both sexes , but in a different way depending on the organ and the fibrinolytic parameter studied and the sex as well . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In persons with elevated Lp ( a ) , plasma TPA levels were higher than in persons with low Lp ( a ) [ 15 . 7 + / 1 . 5 vs . 11 . 7 + / 1 . 2 micrograms / l ; p = 0 . 051 ] , but plasminogen activator inhibitor ( PAI ) activity and the plasma concentrations of PAI 1 were also higher . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To establish the plasma evolution of prothrombin fragments 1+2 ( F 1+2 ) , thrombin antithrombin 3 complexes ( TAT ) , fibrin fragment D Dimers ( DD ) , von Willebrand factor antigen ( vWf ) , Type 1 plasminogen activator inhibitor antigen ( PAI ) and blood platelet count during normal pregnancy and to compare these values with those obtained in hypertensive or pre eclamptic pregnancies . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The increase in urokinase activity was associated with an upregulation of urokinase RNA levels and of the RNAs corresponding to the plasminogen activator inhibitors , PAI 1 and 2 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Mice with combined homozygous deficiency of tissue type plasminogen activator ( t PA ) and urokinase type plasminogen activator ( u PA ) ( T U ) , of t PA and plasminogen activator inhibitor 1 ( PAI 1 ) ( T P ) , of u PA and PAI 1 ( U P ) or of t PA , u PA , and PAI 1 ( T U P ) were generated by inbreeding of mice with the respective deficiencies . ^^^ Thus , the phenotype of mice with combined deficiency of t PA and PAI 1 or of u PA and PAI 1 is similar to the phenotype observed in mice with single deficiency of the plasminogen activator . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma levels of tissue type plasminogen activator ( tPA ) , plasminogen activator inhibitor ( PAI ) , fibrinogen ( Fg ) , thromboxane B 2 ( TXB 2 ) , 6 ketoprostaglandin F 1 alpha ( 6 keto PGF 1 alpha ) , renin activity ( PRA ) and angiotensin 2 ( ANGII ) were assayed in 18 patients with coronary heart disease and 11 healthy subjects before and after submaximal treadmill exercise test according to `` Bruce programme ' ' . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We measured plasma levels of lipoprotein ( a ) [ Lp ( a ) ] , the active form of plasminogen activator inhibitor ( active PAI ) , thrombin antithrombin 3 complex ( TAT ) and soluble thrombomodulin ( TM ) , to investigate the relationship of these factors to thrombotic events in APAS . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Euglobulin clot lysis time was significantly prolonged 1 and 4 h after injection and tissue plasminogen activator ( tPA ) activity declined 4 h following administration with a simultaneous increase in its inhibitor ( PAI ) activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The diminished PA activities in the ventral prostates of rats castrated for 7 days or longer appeared to be due at least in part to an increase in plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the patient and control groups , von Willebrand factor ( vWF ) , tissue plasminogen activator ( tPA ) , and plasminogen activator inhibitor ( PAI ) levels were determined using ELISA method and antithrombin 3 ( AT 3 ) by nephelometric methods . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
While TPA treatment evoked a temporary increased expression of urokinase type PA ( uPA ) , the production of both types of human plasminogen activator inhibitors ( PAI ) was induced and sustained over 12 h by TPA treatment shifting the protease protease inhibitors balance in favor of the inhibitors . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVES : The aim of this study was to investigate the secretion of prostacyclin ( PGI 2 ) , tissue plasminogen activator ( tPA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) produced by human great saphenous vein endothelial cells ( HSVECs ) in vitro when seeded to confluency on different matrices . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Serum levels of pro and counterinflammatory compounds and plasma levels of plasminogen activator inhibitor ( PAI ) 1 were significantly higher in nonsurvivors . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
On diagnosis , blood was drawn , and plasma levels of tissue type plasminogen activator ( t PA ) , plasminogen activator inhibitor ( PAI ) , D dimer ( DD ) , and tissue factor pathway inhibitor ( TFPI ) were determined . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In contrast , plasma levels of plasminogen activator inhibitor ( PAI ) were modestly enhanced in the treatment group . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Ang 2 caused a 10 fold stimulation of plasminogen activator inhibitor 1 ( PAI 1 ) messenger RNA ( mRNA ) in WKY rat brain neuronal cultures . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To further investigate possible involvement of the PA system , we quantified immunoreactive urokinase type plasminogen activator ( u PA ) , tissue type plasminogen activator ( t PA ) , both plasminogen activator inhibitors ( PAI 1 and PAI 2 ) and u PA receptor ( u PAR ) in synovial tissue extracts of 14 patients with rheumatoid arthritis ( RA ) and 12 with osteoarthritis ( OA ) . u PA , PAI 1 , PAI 2 and u PAR concentrations were significantly higher in RA than in OA patients . t PA antigen levels were significantly lower in RA than in OA synovial tissue extracts . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : In patients undergoing gastric surgery for malignant ( n = 18 ) or benign ( n = 21 ) disorders . , blood drawn from the portal vein and a peripheral vein was analysed for tissue type plasminogen activator antigen and activity ( tPA : Ag , tPA : Act ) , single chain urokinase type plasminogen activator activity ( scuPA : Act ) , and plasminogen activator inhibitor antigen and activity ( PAI : Ag , PAI : Act ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Antiplasmin and protein C levels are lower in winter in both young and old while plasminogen activator inhibitor ( PAI ) is higher , and tPA higher in old people only . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The plasminogen activator inhibitor ( PAI ) activity in plasma was clearly increased in CsA treated patients : 14 . 5+ / 8 . 8 vs 7 . 2+ / 3 . 2 in normal controls and 8 . 5+ / 2 . 4 AU / ml in patients without CsA . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
All fibrinolysis markers , that is , D dimer , tissue plasminogen activator antigen ( t PA antigen ) , tissue plasminogen activator activity ( t PA activity ) , plasminogen activator inhibitor activity ( PAI ) and protein C indicated enhanced fibrinolysis by IVRA , but only t PA antigen and PAI showed greater changes in the lignocaine compared with the saline group in the exposed arm at the time of cuff deflation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Levels of tissue type plasminogen activator ( T PA ) , its inhibitor ( PAI 1 ) and fibrinogen in the blood of patients with type 1 and 2 diabetes mellitus ] . ^^^ BACKGROUND : Fibrinogen ( Fgb ) , the tissue activator of plasminogen ( t PA ) and its inhibitor ( PAI 1 ) are described as so called cardiovascular risk factors . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
These findings are discussed along with our previous findings showing normal tissue plasminogen activator ( tPA ) but lower D dimer and higher plasminogen activator inhibitor ( PAI ) levels within the first few hours of life in preterm infants who later developed RDS compared to the control group . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Moreover , Group 1 and 2 displayed significantly higher levels of factor 7 , fibrinogen , F1+2 , thrombin antithrombin complex and plasminogen activator inhibitor ( PAI ) post venous occlusion and significantly lower levels of tissue plasminogen activator ( t PA ) post venous occlusion than Group 3 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Upon transfection , wild type T beta R 1 restored the TGF beta signals for growth inhibition and production of plasminogen activator inhibitor 1 ( PAI ) 1 and fibronectin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Production of tissue type plasminogen activator ( t PA ) and type 1 plasminogen activator inhibitor ( PAI 1 ) in mildly cirrhotic rat liver . ^^^ We have studied the production of tissue type plasminogen activator ( t PA ) and type 1 plasminogen activator inhibitor ( PAI 1 ) in liver of normal rats and in rats with mild cirrhosis induced by carbon tetrachloride inhalation , to demonstrate the production of these fibrinolytic components and their pathophysiologic role in the liver in vivo . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The experimental models of cultured porcine aortic endothelial cells ( EC ) in vitro were established . 6 keto prostaglandin F 1 alpha ( 6 keto PGF 1 alpha ) , thromboxane B 2 ( TXB 2 ) content , plasminogen activator ( PA ) , plasminogen activator inhibitor ( PAI ) activity in cultured medium and cyclic adenosine monophosphate ( cAMP ) level in EC were measured with radioimmunoassay ( RIA ) , chromogenic substrates methods , in order to assess the effect and mechanism of captopril ( CP ) on antithrombus function of EC . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In comparision with the control group , the function of platelet in the treated group demonstrated lower platelet aggregation rate ( PAgR ) and plasma thromboxane A 2 ( TXA 2 ) level , higher prostacyclin ( PGI 2 ) and plasminogen activator ( PA ) activity as well as lower plasminogen activator inhibitor ( PAI ) activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator ( PA ) , plasminogen activator inhibitor ( PAI ) , and urokinase type PA receptor ( uPAR ) antigen concentrations were determined by enzyme linked immunosorbent assay . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasmin can specifically inhibit the biosynthesis of tissue type plasminogen activator ( t PA ) , but not plasminogen activator inhibitor , type 1 ( PAI 1 ) in endothelial cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Artificially induced rat decidual tissue expresses plasminogen activator inhibitor ( PAI ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The present study was performed to investigate the relationship between the concentrations of tissue type plasminogen activator ( t PA ) and plasminogen activator inhibitor ( PAI ) and the CT images in 23 cases of chronic subdural hematomas ( SDHs ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We report a family with a partial deficiency of plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^ The characteristic abnormalities of fibrinolysis in the patients were shortened eugloblin lysis time , low PAI activity with low antigen levels of plasminogen activator inhibitor 1 in plasma and serum . ^^^ Furthermore , plasma ' active PAI ' which indicates the quantity of plasminogen activator inhibitor 1 bound with plasminogen activator added was very low in these patients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Statistically significant variations in the fibrinolytic factors analysed ( tissue plasminogen activator ( t PA ) and plasminogen activator inhibitor ( PAI ) were not observed during the menstrual cycle . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Cultured human mesangial cells ( HMC ) derived from normal kidneys have been shown to synthesize tissue type plasminogen activator ( t PA ) and excess amounts of PA inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Endotoxin induced intravascular coagulation in rabbits : effect of tissue plasminogen activator vs urokinase of PAI generation , fibrin deposits and mortality . ^^^ Results indicated that urokinase and low dose of t PA significantly reduced the increase of plasminogen activator inhibitor ( PAI ) activity observed 2 h after endotoxin ( p < 0 . 001 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Since restriction of energy intake has been demonstrated to act beneficially on the aging process in a variety of species , we studied the effect of a 10 week moderately energy restricted ( ER ) regimen ( 80 % of habitual ) on plasminogen activator inhibitor ( PAI ) activity , PAI 1 antigen , tissue plasminogen activator ( tPA ) activity , and tPA antigen in non obese , middle aged men . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We compared intraindividual and interindividual variability in the plasma levels of fibrinogen , tissue type plasminogen activator ( TPA ) antigen , plasminogen activator inhibitor ( PAI ) activity , and C reactive protein ( CRP ) in 20 healthy , young individuals and 26 patients with stable angina pectoris ( AP ) who were at higher risk for cardiovascular disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In all patients the plasma levels of F 1 + 2 and of plasminogen activator inhibitor ( PAI ) were also determined . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the present study , the bolus administration of defibrotide in humans was able to induce ( 100 800 mg ) a dose dependent decrease in plasminogen activator inhibitor ( PAI ) ( from 19 . 4 + / 7 . 11 to 7 . 20 + / 6 . 41 AU / mL ) and an increase in t PA ( from 3 . 70 + / 0 . 96 to 4 . 50 + / 1 . 20 IU / mL ) and in the stable prostacyclin derivative 6 keto PGF 1 alpha ( from 18 . 83 + / 3 . 83 to 26 . 75 + / 8 . 48 pg / 0 . 1 mL ) in the venous blood . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Defibrotide , a polydeoxyribonucleotide , has been found to modulate endothelial cell function , causing an increase in tissue plasminogen activator ( t PA ) levels , a decrease in plasminogen activator inhibitor ( PAI ) levels , and an increase in prostaglandin I 2 ( PGI 2 ) formation in humans . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : To elucidate the effect of niceritrol on fibrinolysis and Lp ( a ) levels , we examined plasminogen activator inhibitor ( PAI ) activity , tissue type plasminogen activator ( t PA ) antigen , and serum Lp ( a ) levels before and after administration of niceritrol to coronary artery disease patients with high baseline Lp ( a ) levels ( > or = 20 mg / dl ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The pharmacokinetics of a single intraperitoneal dose of 0 . 5 or 2 . 0 mg / ml human rtPA were assessed in rats with fecal peritonitis and related to their endogenous tPA and plasminogen activator inhibitor ( PAI ) activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
At onset of fever , plasminogen activator inhibitor ( PAI ) activity and PAI 1 antigen levels increased from normal baseline levels and were significantly higher in the group of patients who developed septic shock compared to those with severe sepsis ( medians : 10 . 6 versus 1 . 3 U / ml , p = 0 . 0001 ; 50 . 0 versus 5 . 0 ng / ml , p = 0 . 0002 ) . ^^^ The increase in PAI activity and antigen in septic shock was accompanied by an increase in tissue type plasminogen activator antigen and total fibrin ( ogen ) degradation products and a decrease in alpha ( 2 ) antiplasmin activity ( p < 0 . 006 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Neither tissue plasminogen activator ( t PA ) activity , tissue plasminogen activator ( t PA ) antigen nor plasminogen activator inhibitor ( PAI ) antigen changed during the Mg infusion period . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
PATIENTS AND METHODS : In 50 consecutive node positive breast cancer patients , serial coagulation studies ( fibrinogen method of Clauss , antithrombin 3 , protein C amidolytic methods , D dimer enzyme linked immunoadsorbent assay [ ELISA ] techniques , and plasminogen activator inhibitor [ PAI ] activity u PA inhibition test ) and impedance plethysmography ( IPG ) for screening of deep vein thrombosis ( DVT ) were performed preoperatively and postoperatively , before each of six cycles of adjuvant chemotherapy ( 60 mg / m2 epirubicin and 600 mg / m2 cyclophosphamide ) and 3 months thereafter . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Since thromboembolic complications in transplanted patients are generally attributed to combined abnormalities in platelets and coagulo lytic system , some hemostatic parameters tPA ( tissue plasmogin activator ) : Ag and activity , its inhibitor PAIAg and activity , tPA / PAI , thrombin antithrombin ( TAT ) and plasmin antiplasmin complexes ( PAP ) , urokinase uPA , euglobulin clot lysis time ECLT , fibrinogen , plasminogen , protein C activity , D dimer , prothrombin fragments1+2 ( F1+2 ) , fibrin monomers , fibronectin , lipoprotein a , and von Willebrand factor ( vWF ) , were evaluated using commercially available kits . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator ( PA ) and its inhibitor ( PAI ) were identified in TA by reverse fibrin autography and immunoblotting . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The aim of the study was to evaluate fibrinolytic parameters ( antigen of tissue plasminogen activator tPA , its inhibitor PAI , tPA / PAI complexes measured by enzyme immunoassays , euglobulin clot lysis time ECLT ) , cholesterol , triglycerides , lipoprotein ( a ) and apolipoproteins ( AI , AII , B ) in diabetic patients with and without diabetic nephropathy . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Antigen and activity of inhibitor of tissue plasminogen activator ( PAI ) was found to be higher in hypertensive patients relative to control group . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To evaluate the ability of commercial , chromogenic kits designed to measure human fibrinolytic pathway components to measure the canine plasma fibrinolytic pathway enzymes , tissue plasminogen activator ( tPA ) and plasminogen ( PLG ) , and their respective inhibitors , plasminogen activator inhibitor 1 ( PAI ) and alpha 2 antiplasmin ( AP ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
MAIN OUTCOME MEASURES : prothrombin fragment 1 + 2 ( F 1 + 2 ) , thrombin antithrombin 3 ( TAT ) , D dimers ( D D ) , factor 7 activated , plasminogen activator inhibitor ( PAI ) , tissue type plasminogen activator ( t PA ) , plasma albumin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor ( PAI ) activity tended to increase by 17 % ( nonsignificant [ NS ] ) in the atenolol treated group and to decrease by 4 % ( NS ) in the urapidil group . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Hypogonadism in males is associated with an enhancement of fibrinolytic inhibition via increased synthesis of the plasminogen activator inhibitor PAI 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The pharmacokinetic and pharmacodynamic data of 100 and 200 mg were analyzed after intravenous injection and of 50 , 100 and 200 mg after subcutaneous injection on tissue factor pathway inhibitor ( TFPI ) antigen and activity , heparin cofactor ( HC ) 2 activity , HeptestTM coagulation value , chromogenic S 2222 anti factor Xa ( aXa ) assay , activated partial thromboplastin time ( APTT ) , thrombin clotting time ( TCT ) , plasminogen , tissue plasminogen activator activity ( t PA ) and plasminogen activator inhibitor ( PAI ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The concentration of plasminogen activator inhibitor ( PAI ) 1 was increased by a factor of about 800 ( median 395 versus 0 . 5 ng / ml , P < 0 . 05 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
There was no difference in plasminogen activator inhibitor ( PAI ) 1 level between carcinoma and normal mucosa . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Activity of tissue plasminogen activator ( tPA ) inhibitor ( PAI ) and PAI : Ag were higher in ARF , whereas tPA : Ag , urokinase , tPA / PAI complexes , thrombin antithrombin complexes ( TAT ) , plasmin antiplasmin ( PAP ) complexes , fibrinogen , and F1+2 did not differ between ARF and controls . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activators and plasminogen activator inhibitors ( PAI ) were measured by chromogenic substrate assay and binding to 125I urokinase followed by 10 % sodium dodecyl sulphate polyacrylamide gel electrophoresis ( SDS PAGE ) , respectively . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Nitric oxide ( NO ) suppresses platelet aggregation and plasminogen activator inhibitor ( PAI ) release from platelets , playing physiological and / or pathological roles in the haemostatic system . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The plasminogen activator inhibitor type 2 ( PAI 2 ) is present in its high molecular weight , glycosylated form in pregnancy plasma . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Urokinase plasminogen activator ( uPA ) generates plasmin , a process inhibited by plasminogen activator inhibitor ( PAI ) 1 and localized to the cell surface by binding of uPA to a specific receptor . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
With the reagents used , protein S , prothrombin fragment 1 + 2 ( F 1 + 2 ) , D Dimers ( D D ) , plasminogen activator inhibitor ( PAi ) levels could not be determined . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In order to clarify a role of stromal cells in sex steroidal neovascularization , plasminogen activator inhibitor ( PAI ) 1 [ an inhibitor of tissue type plasminogen activator ( tPA ) and urokinase type plasminogen activator ( uPA ) ] and its messenger ribonucleic acid ( mRNA ) were analysed in fibroblasts derived from uterine endometrium as a model for endometrial stromal cells under the influence of sex steroids . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The fibrinolytic system is activated during CPB , with raised tissue plasminogen activator ( tPA ) levels and related falls in plasminogen activator inhibitor ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : Hypertriglyceridaemia ( HTG ) , glucose intolerance , insulin resistance and elevated plasma activity of plasminogen activator inhibitor ( PAI ) 1 are risk factors for ischaemic heart disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
An increase in plasma plasminogen activator inhibitors ( PAIs ) , fundamentally PAI type 2 ( PAI 2 ) , has been described in normal pregnancy probably because the placenta is the main source of the high plasma levels of this protein . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Many lines of evidence support an involvement of urokinase plasminogen activator ( uPA ) and its type 1 inhibitor ( PAI 1 ) in the migration of a variety of cells , including normal keratinocytes and carcinoma lines . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
With the exception of the plasminogen activator inhibitor ( PAI ) 1 transcript , other IL 1 alpha response gene mRNAs were not induced in senescent IMR 90 , although the mRNA for each gene was induced by exogenous IL 1 alpha . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This study demonstrated the profile of the neutral proteinases , 1 ) matrix metalloproteinases ( MMP ) 1 , 2 , 3 , and 9 , and 2 ) serine proteinases , elastase , cathepsin G , urokinase and tissue type plasminogen activators ( uPA and tPA ) as well as their inhibitors , namely , tissue inhibitor of matrix metalloproteinases ( TIMP ) 1 , alpha 1 antitrypsin , alpha 1 antichymotrypsin , plasminogen activator inhibitor ( PAI ) 1 & 2 , around loose hip prostheses to clarify the step in the cascade of biological host response in the loosening of replaced total hip joints . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In an attempt to characterise further the coagulopathy of childhood nephrotic syndrome , this study concentrates on simultaneous measurements of the natural anticoagulants [ antithrombin 3 ( ATIII ) , proteins C and S ] and the fibrinolytic factors , tissue plasminogen activator ( tPA ) and plasminogen activator inhibitor ( PAI ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Available plasmin , required for MMP zymogen activation , is regulated by plasminogen activators ( uPA , tPA ) and plasminogen activator inhibitors ( PAI 1 , PAI 2 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma plasminogen activator inhibitor 1 ( PAI 1 ) level was observed to be associated with sequence variations at the PAI 1 locus . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma plasminogen activator inhibitors ( PAI ) levels are known to be associated with levels of atherogenic lipids . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Sex steroids regulate the expression of plasminogen activator inhibitor 1 ( PAI 1 ) and its mRNA in uterine endometrial cancer cell line Ishikawa . ^^^ To know the effects of sex steroids on the potentials of growth , invasion , and metastasis with neovascularization of endometrial cancer , the expression of plasminogen activator inhibitor ( PAI ) 1 [ an inhibitor of tissue type plasminogen activator ( tPA ) and urokinase type plasminogen activator ( uPA ) ] and its mRNA in well differentiated uterine endometrial cancer cell line Ishikawa was determined by an enzyme linked immunosorbent assay and reverse transcription polymerase chain reaction Southern blotting ( RT PCR SB ) , respectively , under the influence of sex steroids . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
PURPOSE : The purpose of the examination was evaluation of tissue plasminogen activator ( t PA ) concentration and plasminogen activator inhibitor ( PAI ) activity in aqueous humor of the eye and plasma of blood in patients operated on cataract . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
MAIN OUTCOME MEASURES : Fibrinogen , prothrombin time ( PT ) , coagulant activity of Factor 7 ( F VIIc ) and Factor 7 antigen ( F VIIag ) , and plasminogen activator inhibitor ( PAI ) levels were studied . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor ( PAI ) activity was significantly higher in PBC ( 0 . 0041 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
TGF beta is activated by plasmin which is positively regulated by plasminogen activator ( PA ) and PA receptor ( PAR ) , and negatively regulated by plasminogen activator inhibitor ( PAI ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Compared to the controls , plasma levels of tissue type plasminogen activator ( t PA ) , urokinase type plasminogen activator ( u PA ) and plasminogen activator inhibitor ( PAI ) 1 antigen , D Dimer and enhanced thrombin generation were significantly ( P < 0 . 0001 ) increased in children with the common factor 5 mutation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Introduction of an RRHR motif into chicken urokinase type plasminogen activator ( ch uPA ) confers sensitivity to plasminogen activator inhibitor ( PAI ) 1 and PAI 2 and allows ch uPA mediated extracellular matrix degradation to be controlled by PAI 1 . ^^^ Comparison of the amino acid sequence of the chicken and human urokinase type plasminogen activators ( uPAs ) revealed that the putative PAI binding site found in the variable region 1 ( VR 1 ) loop of mammalian PAs is absent in the homologous region of ch uPA . ch uPA , unlike mammalian PAs , also appears to be refractory to inhibition by human PAIs and as a naturally occurring PAI resistant variant , constitutes a unique model system for assessing the functional relevance of the PAI binding site . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The upregulation of plasminogen activator inhibitor 1 ( PAI 1 ) antigen due to LPS ( 1 microgram / mL for 12 hours ) in human umbilical vein endothelial cells ( HUVECs ) was prevented when the cells were incubated simultaneously with 100 micrograms / mL NG R 1 ( PAI 1 antigen : LPS treated cells , 969 + / 54 ng / 10 ( 5 ) cells ; control cells , 370 + / 15 ng / 10 ( 5 ) cells ; LPS + NG R 1 treated cells , 469 + / 29 ng / 10 ( 5 ) cells ; n = 6 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We measured tissue plasminogen activator ( t PA ) and tissue plasminogen activator inhibitor ( PAI ) , using COA SET , t PA and COA TEST PAI ( Chromogenix ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To study the hemostatic profile and endothelial cell state , we measured the blood pressure ( BP ) , hematocrit and lipid profiles as well as fibrinogen , a marker of fibrin turnover ( D dimer ) , fibrinolytic factors ( plasmin alpha 2 plasmin inhibitor complex [ PIC ] , tissue type plasminogen activator [ t PA ] antigen and t PA inhibitor [ PAI ] activity ) and an endothelial cell derived marker ( von Willebrand factor [ vWF ] ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : In a case control study of 105 cases of transient ischaemic attack and minor ischaemic stroke , and 241 controls , data were available on levels of the haemostatic factors von Willebrand factor ( vWF ) , plasminogen activator inhibitor 1 ( PAI ) , tissue plasminogen activator ( TPA ) and factor 7 ( FVII ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
PURPOSE : Endothelial cells produce many biologically important factors that may be used as functional markers , including plasminogen activators and their inhibitors ( PAI ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In addition , there is evidence that limited weight loss ( < 7 kg ) decreases levels of the haemostatic factors , factor 7 and PAI , while increasing the tissue plasminogen activator levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Serum ACE activity and plasma fibrinolytic variables [ plasminogen activator inhibitor ( PAI ) activity , plasminogen activator inhibitor type 1 ( PAI 1 ) antigen level , and tissue type plasminogen activator ( TPA ) antigen level ] were measured . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We studied tissue type plasminogen activator ( t PA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) in healthy individuals divided by smoking habit into current smokers , former smokers and non smokers ( who had never smoked ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To demonstrate that Tat modulates the plasminogen dependent proteolytic activity of tumour cell lines derived from BK virus ( BKV ) / tat transgenic mice by affecting the production of plasminogen activators ( PA ) and the PA inhibitor ( PAI ) 1 and to demonstrate that this occurs through mechanism ( s ) that are distinct from those responsible for transactivating activity of extracellular Tat . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
It has also been reported that an elevated level of plasminogen activator inhibitor ( PAI ) appears to constitute a marker of the risk of recurrent coronary thrombosis . ^^^ To determine whether the ACE inhibitor captopril reduces plasma PAI inhibitor activity , we measured changes in plasma PAI activity ( IU / ml ) , tissue plasminogen activator ( t PA ) antigen ( ng / ml ) , and serum ACE activity ( IU / L ) in 14 survivors of myocardial infarction receiving captopril therapy ( 37 . 5 mg daily ) and compared them with the values in 15 placebo treated patients chosen at random . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The main function of plasminogen activator inhibitor type 1 ( PAI 1 ) is to decrease fibrinolysis , which leads to fibrin accumulation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Platelet count ( PLT ) , PT , aPTT , fibrinogen ( Fib ) , prothrombin fragment F1+2 , antithrombin ( AT ) , protein C ( PC ) , protein S ( PS ) , factor 13 ( FXIII ) , plasminogen ( PLG ) , plasminogen activator inhibitor ( PA 1 ) , spontaneous platelet aggregation in platelet rich plasma ( PRP SPA ) and in whole blood ( WB SPA ) , and antiphospholipid antibodies ( aPL ) were evaluated . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
STUDY DESIGN : One hundred and seventeen normal pregnant women were investigated in a longitudinal study involving five measurements : blood samples were collected at 10 , 20 , 30 , 36 weeks and on the second day puerperium and were assayed for prothrombin time ( PT expressed in INR ) , activated partial thromboplastin time ( PTT ) , fibrinogen ( FBG ) , antithrombin 3 activity ( AT 3 ) , protein C activity ( PC ) , protein S activity ( PS ) , prothrombin fragments 1+2 ( F1+2 ) , type 1 plasminogen activator inhibitor activity ( PAI ) and tissue plasminogen activator antigen ( t PA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
On the other hand , it is known that high levels of TG can be associated with high levels of circulating plasminogen activator inhibitor ( PAI ) , which is also a possible risk factor for CAD . ^^^ The following plasma fibrinolytic parameters were measured : tissue plasminogen activator antigen , PAI antigen and activity , euglobulin fibrinolytic activity ( EFA ) on fibrin plates , plasminogen and alpha 2 antiplasmin activities . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma levels of active plasminogen activator inhibitor ( PAI ) in type IIb and 4 were significantly higher than in normals . ^^^ In the diabetics , the levels of Lp ( a ) as well as levels of tissue type plasminogen activator ( t PA ) antigen and PAI activity were significantly higher than normal controls . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : We measured preoperative levels of fibrinogen , cross linked fibrin degradation products ( FDP ) , and the endothelial markers , von Willebrand factor ( vWF ) , tissue plasminogen activator ( tPA ) , and plasminogen activator inhibitor ( PAI ) , in the venous blood of 43 claudicants undergoing percutaneous transluminal angioplasty ( PTA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Measurements of the plasma concentrations of free tissue type plasminogen activator ( t PA ) activity , tissue type plasminogen activator ( t PA ) antigen , plasminogen activator inhibitor ( PAI ) activity , plasminogen activator inhibitor 1 ( PAI 1 ) antigen , plasminogen ( Plg ) activity , plasminogen ( Plg ) antigen , alpha 2 antiplasmin ( alpha 2 AP ) , D dimer and fibrin degradation products ( FbDP ) were all determined and the area under the curve ( AUC ) for each of these quantities correlated with the blood loss . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Among the other parameters tested , plasminogen activator inhibitor ( PAI 1 ) antigen concentration and PAI activity were similar in septic and non septic intensive care patients , but higher than in healthy controls . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Patients had higher Willebrand factor antigen ( vWF ) , tissue type plasminogen activator antigen ( t PA ) , plasminogen activator inhibitor activity ( PAI ) and D dimers ( D Di ) than the reference women . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In 15 patients we investigated coagulation parameters before , during and post CPB , i . e . , fibrinogen , antithrombin ( AT ) 3 , thrombin antithrombin complex ( TAT ) , prothrombin fragments F 1 + 2 ( F 1 + 2 ) , factor ( F ) XIIa , tissue factor ( TF ) , and parameters of the fibrinolytic system , i . e . , plasmin antiplasmin complex ( PAP ) , D dimer , tissue plasminogen activator ( tPA ) , urokinase type plasminogen activator ( uPA ) , and plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
RESULTS : Plasma fibrinogen levels were related to insulin ( r = 0 . 25 , P < 0 . 01 ) and proinsulin ( r = 0 . 29 , P < 0 . 001 ) , as was plasminogen activator inhibitor ( PAI ) 1 activity ( r = 0 . 36 and r = 0 . 29 , respectively ; P < 0 . 001 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : Fifty patients with SAH caused by ruptured cerebral aneurysms were studied postoperatively to detect the serial changes of the thrombin antithrombin 3 complex , active plasminogen activator inhibitor ( PAI ) 1 , and tissue plasminogen activator ( tPA ) PAI complex ( tPA PAI ) activities in the plasma and CSF collected from cisternal drainage catheters . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Treatment with endotoxin leads to a rise in plasminogen activator inhibitor 1 ( PAI 1 ) both in vivo and in vitro . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We recently showed that both plasminogen activator inhibitor 1 ( PAI 1 ) and tissue factor ( TF ) are induced after a massive hemorrhage . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : Plasma antithrombin ( AT 2 ) , fibronectin ( Fn ) , plasminogen activator inhibitor ( PAI ) levels were determined at 26 28 , 37 38 gestational weeks and 24 72 hours after delivery in 114 pregnant women whose mean arterial pressure ( MAP ) > or = 12 kPa or body weight index > or = 0 . 24 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In a model of chronic cyclosporine ( CsA ) nephropathy , we previously showed that TGF beta 1 plays a role in CsA induced tubulointerstitial fibrosis and arteriolopathy by stimulating extracellular matrix ( ECM ) protein synthesis and inhibiting ECM degradation through increasing the synthesis of plasminogen activator inhibitor ( PAI ) 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In vitro studies suggest that oxidized low density lipoprotein inhibits fibrinolysis by stimulating the production of plasminogen activator inhibitor 1 ( PAI ) . ^^^ However , antioxidant vitamins had no effect on plasma PAI activity , PAI antigen , tissue type plasminogen activator activity and antigen , fibrinogen and fibrin degradation products . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
There were significant increases of the von Willebrand factor ( vWf ) , plasminogen activator inhibitor 1 ( PAI ) and tissue plasminogen activator ( tPA ) starting at CPB end and rising to about twice the baseline levels postoperatively . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To compare the plasminogen activators ( tPA , uPA ) and their inhibitors ( PAI 1 , PAI 2 ) at different gestational ages , related to levels in women at term and non pregnant women . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We measured sequential changes in plasma levels of the hemostatic factors ( fibrinogen , fibrin D dimer , and plasminogen activiator inhibitor [ PAI ] ) , markers of platelet function ( soluble leukocyte adhesion molecule P selectin ) and endothelial function ( von Willebrand factor [ vWf ] , soluble thrombomodulin [ sTM ] , and tissue plasminogen activator [ TPA ] ) , and serum lipid levels , including lipoprotein A . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Bulk of tPA activity is in the proximity of the endogenous plasminogen activator inhibitor ( PAI ) as an active complex . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor ( PAI ) activity and antigen and fibrinogen were also assessed in the preocclusion sample . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In addition to infiltrating cells , mesothelial cells have been demonstrated to actively participate in pleural inflammation via release of various mediators and proteins , including platelet derived growth factor ( PDGF ) , interleukin 8 , monocyte chemotactic peptide ( MCP 1 ) , nitric oxide ( NO ) , collagen , antioxidant enzymes and the plasminogen activation inhibitor ( PAI ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This study was designed to examine the levels of plasma plasminogen activator inhibitor ( PAI ) activity and serum ACE activity during the course of 2 weeks in 40 patients with AMI within 12 hours after the onset of the symptom and who randomly received early treatment with either the ACE inhibitor imidapril or a placebo ( 20 patients in the imidapril group and 20 in the placebo group ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVES : Clinical manifestations of coronary heart disease result primarily from the progressive development of atherosclerotic plaques and subsequent thrombus formation : processes which may be accelerated by an enhanced expression of plasminogen activator inhibitor ( PAI 1 ) in the vessel wall . ^^^ Both free PAI 1 and PAI 1 complexed with plasminogen activators were significantly increased in extracts of advanced lesions . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We performed a cross sectional study of 178 patients attending a hypertension clinic in a city center teaching hospital , and measured plasma levels of the soluble adhesion molecule P selectin ( associated with platelet activity / function and atherosclerosis ) , the von Willebrand factor ( vWf ; a marker of endothelial dysfunction ) , fibrin D dimer ( an index of thrombogenesis ) , plasminogen activator inhibitor ( PAI , an index of fibrinolysis ) , lipoprotein ( a ) ( Lp ( a ) , associated with thrombogenesis and atherogenesis ) and hemorheological indexes ( fibrinogen , hematocrit , plasma viscosity , hemoglobin ) in patients with essential hypertension , in whom the LV mass and LV mass index were determined using echocardiography . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma levels of thrombin antithrombin 3 complexes ( TAT ) , the plasmin alpha 2 antiplasmin complexes ( PAP ) , tissue type plasminogen activator ( tPA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) were measured within 48 h after admission , together with respiratory variables allowing computation of the lung injury score ( LIS ) , and pulmonary microvascular permeability [ 67Gallium transferrin pulmonary leak index ( PLI ) ] , as measures of pulmonary dysfunction . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We found elevated apolipoprotein A 1 and Apo E concentrations in acromegalic patients compared to controls ( apo A 1 : 1 . 79 + / 0 . 06 vs . 1 . 46 + / 0 . 04 g / l ; p < 0 . 01 ; apo E : 98 . 35 + / 6 . 4 vs . 72 . 53 + / 3 . 38 mg / l ; p < 0 . 05 ) . 30 % of the acromegalics showed increased plasminogen activator inhibitor activity ( PAI ) while 66 % had increased tissue type plasminogen activator ( t PA ) concentrations . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Since APC did not enhance plasma fibrinolytic activity , as assessed by the measurement of plasminogen activator ( PA ) or PA inhibitor ( PAI ) activities , PAI 1 antigen , or 125I fibrin degrading activity , we speculate that the inhibition of additional ( endogenous ) thrombin formation by APC interrupts thrombin dependent mechanisms that make fibrin clots more resistant to lysis , so that the intravascular deposited fibrin can be removed more rapidly by the endogenous fibrinolytic system . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Antithrombin 3 , C protein ( CP ) , plasminogen , plasminogen activator inhibitor ( PAI ) , total S protein ( TSP ) , free S protein ( FSP ) , lupus anticoagulant ( LA ) and anticardiolipin antibodies ( ACA ) type IgG were determined in all patients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma levels of fibrin D dimer , tissue plasminogen activator ( tPA ) and plasminogen activator inhibitor ( PAI ) have been associated with ischaemic heart disease ( IHD ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The quantities of t PA and plasminogen activator inhibitor ( PAI ) were determined using enzyme linked immunosorbent assays . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Urokinase plasminogen activator ( uPA ) , plasminogen activator inhibitor ( PAI ) 1 and 2 , and soluble uPA receptor ( suPA R ) concentrations were assayed by enzyme linked immunosorbent assay ( ELISA ) in the conditioned media . uPA and PAI 2 concentrations were not influenced by steroid treatment and did not differ between women with and without endometriosis , whereas PAI 1 was significantly up regulated by promegestone in both groups . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Its activity during metastasis may be regulated by a plasminogen activator inhibitor ( PAI ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Thrombin antithrombin 3 complex ( TAT ) , D dimer , tissue plasminogen activator ( t PA ) and plasminogen activator inhibitor ( PAI ) 1 antigens ( Ag ) , t PA activity , and plasmin alpha 2 antiplasmin complex ( PAP ) , as well as plasma catecholamines , were measured before and after a treadmill exercise test . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Expression of proteolytic parameters of the urokinase type plasminogen activator ( uPA ) system [ uPA receptor ( uPA R ) , plasminogen activator inhibitor ( PAI ) 1 ] has been proven to be an independent prognostic parameter in cancer . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
RESULTS : Both on day 0 and day 10 , patients with an acute coronary syndrome had a marked elevation of t PA mass concentration ( mean value + / SEM 14 . 4 + / 1 . 6 [ day 0 ] , 18 . 9 + / 2 . 5 ng / ml [ day 10 ] ) and of plasminogen activator inhibitor ( PAI ) ( 9 . 4 + / 2 . 2 [ day 0 ] , 11 . 3 + / 2 . 6 AU / liter [ day 10 ] , p < 0 . 05 vs . patients with stable angina ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Factor 13 genotype was determined through a single stranded conformational polymorphism technique and plasminogen activator inhibitor ( PAI ) 1 4G / 5G promoter genotype by allele specific polymerase chain reaction . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To substantiate in a premenopausal population of women , the link between visceral adipose tissue and circulating plasminogen activator inhibitor 1 ( PAI 1 ) levels . ^^^ Insulin , cholesterol , triglyceride , HDL cholesterol , PAI 1 activity , PAI 1 antigen and tissue plasminogen activator ( tPA ) antigen . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We applied monoclonal antibodies against MMP 1 , 2 , 3 , 9 and their inhibitors TIMP 1 / 2 , as well as against urokinase plasminogen activator u PA and its inhibitor PAI to investigate their influence on articular cartilage degradation in patients with varusgonarthritis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To evaluate the effects of a gonadotropin releasing hormone agonist ( GnRH a ) on plasminogen activator ( PA ) , matrix metalloproteinase ( MMP ) , plasminogen activator inhibitor ( PAI ) and matrix metalloproteinase inhibitor ( MMPI ) activities in peritoneal fluid relative to GnRH a induced reduction of adhesion formation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The 4G / 5G sequence polymorphism in the promoter of plasminogen activator inhibitor 1 ( PAI 1 ) gene : relationship to plasma PAI 1 level in venous thromboembolism . ^^^ Impaired fibrinolysis due to increased plasminogen activator inhibitor 1 ( PAI 1 ) is observed in up to 40 % of patients with venous thromboembolism and might be causally related to the disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The concentrations of plasma tPA and plasminogen activator inhibitor ( PAI ) 1 and 2 were measured . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This study reports on the predictive value of some haemostatic factors [ fibrinogen , factor 7 and plasminogen activator inhibitor ( PAI ) ] , a marker of endothelial damage ( soluble thrombomodulin ) and several markers of haemostatic system activation ( factor VIIa , prothrombin fragment 1+2 , thrombin antithrombin complexes and D dimers ) on the incidence of vascular events in male , non diabetic patients with chronic ischaemia of the lower limbs . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Both cell lines showed reduced expression of tissue inhibitor of metalloproteases ( TIMP ) 1 , while TIMP 2 and plasminogen activator inhibitor ( PAI ) 1 expression was was also reduced in RSVT2 / C cells , thus contributing to their hyperinvasiveness . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Incubation with lovastatin ( 5 microM ) of proximal tubules isolated from untreated rats induced an increase in tPA and uPA and a decrease in plasminogen activator inhibitor 1 ( PAI 1 ) activities . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
High levels of components of the plasminogen activation system , including urokinase , but paradoxically also its inhibitor , plasminogen activator inhibitor 1 ( PAI 1 ) , have been correlated with a poor prognosis for some cancers . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Abnormal lipid profile and increased levels of plasminogen activator inhibitor ( PAI ) and fibrinogen have been noted in GHD patients . ^^^ Present study was carried out to investigate the effect of growth hormone ( GH ) on plasminogen activator ( PA ) activity in heart , levels of PA , PAI , glucose and fibrinogen in plasma and serum lipid profile . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Samples were then assayed for von Willebrand factor ( vWf ) , tissue type plasminogen activator ( tPa ) , and plasminogen activator inhibitor ( PAI ) levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Whether the post prandial lipemic response is linked to potentially pro atherogenic and / or prothrombotic changes in plasminogen activator inhibitor ( PAI ) and transforming growth factor beta ( TGF beta ) is uncertain . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The expression of urokinase type plasminogen activator ( u PA ) , u PA receptor ( u PAR ) and plasminogen activator inhibitor ( PAI ) 1 and 2 was examined in 105 cases of primary lung cancer tissue using immunohistochemical staining and reverse transcriptase polymerase chain reaction ( RT PCR ) techniques . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Insulin sensitivity ( via Bergman ' s minimal model ) and fasting plasma concentrations of total cholesterol ( TC ) , low density lipoprotein cholesterol ( LDL C ) , triglyceride ( TG ) , glucose , and plasminogen activator inhibitor 1 ( PAI 1 ) activity were not different between the groups . ^^^ However , plasma high density lipoprotein cholesterol ( HDL C ) , HDL 2 C , HDL C / TC , insulin , fibrinogen , fibrin D dimer , PAI antigen , tissue plasminogen activator ( t PA ) activity , and t PA antigen levels all were less favorable ( P < . 05 ) in swimmers versus runners . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Compared to the HB8065 / S cells , the resistant cell line expressed higher level of plasminogen activator inhibitor ( PAI ) 1 mRNA ( approximately threefold ) , which was reflected by a approximately fivefold increase in secreted PAI 1 immunoactivity ( approximately 50 ng / 10 ( 6 ) HB8065 / R cells ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
They determined the in vivo activation of the coagulation system ( TAT , F 1 + 2 ) , the degree of secondary fibrinolysis ( D dimer ) , the plasma levels of the markers of fibrinolysis , with special regard to inhibitors : plasminogen activator inhibitor ( PAI 1 ) , alpha 2 antiplasmin ( alpha 2 AP ) , alpha 2 macroglobulin ( alpha 2 M ) , the frequency of pathologic serum lipoprotein ( a ) Lp ( a ) values and the association of PAI 1 and Lp ( a ) with the fibrinolytic system . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
It has been proved by many authors that fibrinolytic activity is depressed in patients with vascular thrombosis , due to increased levels of fibrinolytic inhibitors mainly plasminogen activator inhibitor ( PAI 1 ) , and / or decreased levels of tissue plasmogen activator ( t PA ) . ^^^ In pregnancy susceptibility to thrombosis follows the presence in blood of PAI 2 , an inhibitor of plasminogen activators secreted by the placenta . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
RESULTS : At the time of opening of the abdominal cavity , levels of plasminogen activator inhibitor ( PAI ) type 1 ( P = 0 . 009 ) and tissue type plasminogen activator ( tPA ) / PAI complex ( P = 0 . 008 ) were increased in peritoneal samples from patients with severe adhesions compared with those in samples from patients with less severe adhesions . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Generation of plasmin is regulated by plasminogen activators ( PA ) and their inhibitors ( PAI ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The primary regulatory element of the fibrinolytic system is plasminogen activator inhibitor ( PAI ) . ^^^ It has been previously observed that there are 2 peaks in the plasma PAI level of AMI patients at 4h and 16h after thrombolytic therapy with recombinant tissue plasminogen activator ( rtPA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
After administration of Cap , malondialdehyde ( MDA ) content and plasminogen activator inhibitor ( PAI ) activity were reduced , 6 keto PGF 1 alpha and cAMP contents were obviously increased ( P < 0 . 05 0 . 01 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : Euglobulin clot lysis time ( ECLT ) , tissue plasminogen activator ( t PA ) activity , and plasminogen activator inhibitor ( PAI ) activity were measured before and after VOT in a group of 26 consecutive patients presenting with retinal vein occlusion and in 15 healthy age and sex matched controls . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
However , our experiments failed to identify any alteration in the plasminogen activator inhibitor ( PAI ) secretion caused by G CSF . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This study compared plasminogen plasma activity , protein C and protein S plasma activities , fibrinogen and fibrin degradation products ( FGDP and FBDP , respectively ) , von Willebrand factor antigen ( vWF Ag ) , prothrombin fragment F1 . 2 , thrombin antithrombin complexes ( TAT ) , tissue plasminogen activator ( tPA ) , and plasminogen activator inhibitor ( PAI ) in 16 patients with PPH and in 16 healthy volunteers . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The plasma factors studied were the following : 1 ) plasma fibronectin and thrombomodulin as markers of endothelial cell damage ; 2 ) beta thromboglobulin as platelet activity markers ; 3 ) 8 : C factor and fibrinopeptide A as coagulation activity markers ; 4 ) coagulation inhibitors such as protein C and protein S activity ; 5 ) tissue plasminogen activator ( t PA ) , plasminogen level and plasminogen activator inhibitors ( PAI ) as fibrinolytic activity markers . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Here , we provide evidence that plasminogen activator inhibitor ( PAI ) 2 has an anti proliferative effect on keratinocytes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The aim of this study was to determine whether enhanced expression of N myc in a neuroblastoma cell line affects the balance of plasminogen activator / plasminogen activator inhibitor ( PA / PAI ) , a shift towards proteolysis having been observed in other malignant tissues . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor ( PAI ) is the most important physiological inhibitor of tissue plasminogen activator in plasma . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Blood samples drawn on admission , on four occasions during operation as well as 2 hours after operation and on the first postoperative day in 50 patients undergoing elective LC were analyzed for prothrombin fragment 1+2 ( F1+2 ) , soluble fibrin ( SF ) , D dimer ( DD ) , fibrin degradation products ( FbDP ) , tissue type plasminogen activator ( tPA ) activity and antigen , and plasminogen activator inhibitor ( PAI ) activity and antigen . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The activity of plasminogen activator inhibitor ( PAI ) decreased in 3 month HCD mice . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The predicted sequence of the new protein shares 33 % sequence identity and 58 % sequence similarity to plasminogen activator inhibitor ( PAI ) 1 and PAI 2 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
DESIGN AND METHODS : Samples of stimulated conditioned media were collected over a period of 24 hours to determine : plasminogen activator ( PA ) and plasminogen activator inhibitor ( PAI ) activity , PAI 1 mRNA , tissue type plasminogen activator ( t PA ) antigen and urokinase type plasminogen activator ( u PA ) antigen . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A third aim was to assess associations between PCOS , 4G / 5G polymorphism in the promoter sequence of the plasminogen activator inhibitor 1 gene ( PAI 1 gene ) , and PAI activity ( PAI Fx ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The targeted ECM degradation generated by plasminogen activator ( PA ) and regulated by plasminogen activator inhibitor ( PAI ) is , therefore , an event that affects a wide variety of physiological and pathological processes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : In this case control cross sectional study in which the oral glucose tolerance ( 75 g OGTT ) and the carotid intima media thickness ( IMT ) with B mode ultrasound , as a marker of atherosclerosis , were measured , together with HbA1c , lipids , plasminogen activator ( PAI ) , insulin and proinsulin concentrations in blood plasma . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The following coagulation tests were performed before and after near maximum exercise : prothrombin time ( PT ) , partial activated thromboplastin time ( PTT ) , fibrinogen ( FBG ) , antithrombin 3 ( ATIII ) , protein C ( PC ) , protein S ( PS ) , prothrombin fragment 1 + 2 ( F 1 + 2 ) , tissue activator of plasminogen ( t PA ) and its inhibitor ( PAI ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
N 3 fatty acids supplementation did not affect the levels of fibrinogen , coagulation factor 7 or tissue factor pathway inhibitor ( TFPI ) , while plasminogen activator inhibitor ( PAI ) increased significantly ( Student ' s t test ; p < 0 . 05 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The changes of plasma lipid peroxide ( LPO ) , superoxide dismutase ( SOD ) , tissue type plasminogen activator ( t PA ) and plasminogen activator inhibitor ( PAI ) and nitric oxide ( NO ) were observed in the patients treated with YQTLP and nitroglycerin , which were compared to 30 healthy subjects . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In this study the effect of a high dose of dexamethasone on plasminogen activator activity ( PAA ) , t PA antigen level , plasminogen activator inhibition ( PAI ) and plasmin inhibition ( Pl ) in rat heart , brain , liver , lungs and kidneys was investigated in both sexes . ^^^ CONCLUSION : These changes of PAA , PAI and t PA antigen level in heart , brain and liver induced by dexamethasone might be of importance regarding the involvement of glucocorticoids and plasminogen activators / plasmin in many pathophysiological conditions . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The increased incidence of cardiovascular diseases in obese subjects could be partially attributed to impaired fibrinolysis due to elevated plasma levels of tissue plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
RESULT : On the basis of univariate correlations , the ABI ratio was found to be significantly and negatively associated not only with the degree of abdominal fat distribution , but also with the usual biological features of resistance to insulin : plasma triglycerides and cholesterol ; plasma glucose and insulin ; and plasminogen activator inhibitor ( PAI ) antigen . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Elevated plasminogen activator mass concentration ( 16 . 6 + / 2 . 1 vs 5 . 4 + / 0 . 6 ng / ml ; P < 0 . 01 ) and plasminogen activator inhibitor ( PAI ) activity ( 9 . 9 + / 3 . 0 vs 5 . 6 + / 3 . 0 AU / ml ; P < 0 . 05 ) indicated an alteration of the fibrinolysis . ^^^ Complexity of coronary stenosis was positively correlated with tissue type plasminogen activator ( TPA ) mass concentration ( P < 0 . 01 ) and PAI activity ( P < 0 . 05 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Subsequently , we measured the plasma levels of mediators such as tumor necrosis factor ( TNF ) alpha , interleukin ( IL ) 6 , IL 8 , plasminogen activator inhibitor ( PAI ) 1 , and thrombomodulin ( TM ) in patients with traumatic shock and septic shock . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma levels of APC , thrombin antithrombin 3 complex ( TAT ) , and plasminogen activator inhibitor ( PAI ) activity were measured in 32 consecutive AMI patients who underwent coronary angiography followed by thrombolytic therapy , and compared to the measurements in 23 control subjects . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor ( PAI ) 1 , a serine protease inhibitor , inactivates urokinase type plasminogen activator ( uPA ) and regulates degradation of the extracellular matrix ; whether it functions for or against tumor progression , however , has been the subject of controversy . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : Disturbances in fibrinolytic activity , such as increase in plasminogen activator inhibitor ( PAI ) activity , have been linked with an increased risk for coronary artery disease ( CAD ) and myocardial infarction ( MI ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor ( PAI ) activity , t PA activity , and prothrombin fragment ( PF ) 1+2 were measured before induction of anesthesia , immediately before aortic clamp release , and 5 minutes and 24 hours after aortic clamp release . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVES : We studied the contribution of putative risk genotypes at the angiotensin 1 converting enzyme inhibitor ( ACE D / D ) and plasminogen activator inhibitor 1 ( PAI 1 4G / 4G ) loci to all cause and cardiovascular mortality in a population based cohort . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
However , in contrast with FTC 236 and FTC 238 , no plasminogen activator inhibitor ( PAI ) or PAI 1 mRNA were found in FTC 133 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
There is evidence that serine proteases , such as tissue plasminogen activator ( TPA ) , urokinase type plasminogen activator ( UPA ) , and plasminogen activator inhibitor ( PAI ) , are involved in this process . ^^^ CONCLUSIONS : A correlation between increased levels of VEGF and TPA or PAI in the vitreous fluid of eyes with PDVR reflects the possible role of plasminogen activators in the progression of this disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Glucose disposal was significantly negatively associated with plasminogen activator inhibitor activity ( PAI ) in the high risk group and with von Willebrand factor in the low risk group . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Recent studies suggest that high plasma levels of tissue type plasminogen activator ( tPA ) and its inhibitor ( plasminogen activator inhibitor 1 , PAI 1 ) are markers of an increased risk of atherothrombotic ischemic events such as stroke and myocardial infarction . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In 41 women with at least one pregnancy drawn from a group of 149 ( 108 never pregnant ) women with polycystic ovary syndrome ( PCOS ) , our specific aim was to determine whether hypofibrinolysis mediated by high plasminogen activator inhibitor activity ( PAI Fx ) is an independent risk factor for miscarriage . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We measured plasminogen activator ( PA ) activity and plasminogen activator inhibiting ( PAI ) activity in 5 , 12 , 45 , and 60 week old male and female rats . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The remaining tissue plasminogen activator ( t PA ) of the sample consisting of beta 2 GPI , two chain recombinant t PA , and plasminogen activator inhibitor ( PAI ) 1 was measured by a chromogenic assay using the synthetic substrate S 2251 , Glu plasminogen , and soluble fibrin monomer . beta 2 GPI protected t PA activity from inhibition by PAI 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Assembly of a TGFbeta induced DNA binding complex on one of two regulatory regions in the human plasminogen activator inhibitor ( PAI ) 1 promoter did not require Smad 4 but was , instead , dependent on a TFE 3 binding site . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Prothrombotic disorders were found in 8 out of 26 patients with cerebral infarction ( FV Leiden mutation : n = 4 ; protein C deficiency : n = 1 ; FV Leiden mutation + protein C deficiency : n = 2 ; prothrombin mutation G20210A : n = 1 ) and in 13 out of 17 with venous thrombosis ( FV Leiden mutation n = 3 ; protein C deficiency n = 5 ; elevated HRGP + PAI : n = 1 , combined deficiency of AT , protein C and plasminogen : n = 1 ; F 12 deficiency : n = 1 ; lupus anticoagulans n = 1 ; FV Leiden + F 12 deficiency + lupus anticoagulans + PAI : n = 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen , plasminogen activator inhibitor ( PAI ) 1 , tissue type plasminogen activator ( t PA ) and urokinase plasminogen activator ( u PA ) were investigated in the pre surgical period and in the postoperative follow up period in children suffering from Ewing sarcoma ( ES ; n = 36 ) or osteosarcoma ( OS ; n = 39 ) . ^^^ Besides a short lasting increase of PAI 1 in patients with OS on day 1 and in children with Es on day 14 , a small and significant but clinically irrelevant difference was found on days 7 10 for plasminogen , t PA and u PA . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Blood samples for coagulation studies ( fibrinogen , von Willebrand factor ( vWf ) , factor 8 : C , antithrombin , protein C , plasminogen , tissue type plasminogen activator ( t PA ) , plasminogen activator inhibitor 1 ( PAI ) , D dimer ) were obtained within two hours of admission , 24 h later , and on days 3 5 , 7 9 , 21 and 35 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
PURPOSE : To measure the tissue plasminogen activator antigen ( t PA Ag ) content and plasminogen activator inhibitor type 1 ( PAI 1 ) activity of SRF and blood . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
At each time interval , tissue plasminogen activator ( tPA ) and tPA inhibitor 1 ( PAI 1 ) antigens and activities and total euglobulin fibrinolytic activity were determined and portal vein flow velocity , volume , and congestion index were measured by duplex Doppler . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The mRNA of HGF , HGF activator , urokinase , plasminogen activator inhibitor ( PAI ) 1 , nexin 1 , matrix metalloproteinase ( MMP ) 2 , and tissue inhibitor of metalloproteinase ( TIMP ) 1 were expressed strongly in anagen tissue and slightly in telogen tissue . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tumor necrosis factor alpha ( TNF alpha ) level , tissue typed plasminogen activator ( t PA ) activity and PA inhibitor ( PAI ) activity were determined in three groups : ( 1 ) 25 NIDDM patients with silent myocardial ischemia ( SMI ) or silent cerebral ischemia ( SCI ) ; ( 2 ) 18NIDDM patients without SMI or SCI ; ( 3 ) 20 age matched normal controls . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The 26 amino acid sequence was 96 % identical to that of pig plasminogen activator inhibitor ( PAI ) 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To investigate the physiological significance of microglia derived plasminogen ( PGn ) in the central nervous system , we determined the effects of rat PGn on the secretion of plasminogen activator inhibitor ( PAI ) in cultured rat astrocytes by reverse zymography and Western blotting . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In vitro experiments show that 1O2 ( 1 ) inhibits coagulation by inactivation of thrombocytes , fibrinogen , factor 5 , factor 8 , and factor 10 and ( 2 ) activates fibrinolysis by inactivation of the main fibrinolysis inhibitors plasminogen activator inhibitor ( PAI ) 1 and alpha 2 antiplasmin , and by activation of single chain urokinase by plasmin and oxidized fibrin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The effect of alpha tocopherol supplementation on testosterone parameters ( mean value , basal level , peak number , mean concentration value during peaks , peak amplitude , peak duration ) and plasminogen activator activity ( PAA ) , plasminogen activator inhibition ( PAI ) and plasmin inhibition ( PI ) of spermatozoa and seminal plasma was studied in the ram during autumn ( estrous period for the sheep in Greece ) and spring ( anestrous period ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue factor ( TF ) is the most powerful activator of the coagulation system , whereas plasminogen activator inhibitor ( PAI ) 1 is a key modulator of the fibrinolytic pathway . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Impaired fibrinolytic function , mainly due to increased plasma plasminogen activator inhibitor 1 ( PAI 1 ) activity , is common in patients with manifest coronary artery disease ( CAD ) and a predictor of recurrent cardiovascular events . ^^^ We investigated the relationships of plasma tissue type plasminogen activator ( tPA ) and PAI 1 antigen levels , plasma PAI 1 activity and PAI 4 / 5 guanosine ( 4G / 5G ) genotype to CAD progression in 203 middle aged men participating in the Lopid Coronary Angiography Trial ( LOCAT ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Congenital plasminogen activator inhibitor 1 ( PAI 1 ) deficiency is an extremely rare disorder characterized by a bleeding diathesis that begins in childhood due to hyperfibrinolysis as a result of decreased PAI 1 activity . ^^^ None of the patients had elevated tissue plasminogen activator ( tPA ) antigen levels , but PAI activity was markedly decreased in all cases . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The increase in fibrinolysis is due to a rise in tissue type plasminogen activator ( tPA ) and decrease in plasminogen activator inhibitor ( PAI ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The remaining tissue plasminogen activator ( t PA ) of the sample consisting of beta 2 GPI , two chain recombinant t PA , plasminogen activator inhibitor ( PAI ) 1 was measured by a chromogenic assay using synthetic substrate S 2251 , Glu plasminogen , and soluble fibrin monomer . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) regulates plasmin activation through the tissue plasminogen activators . ^^^ A polymorphism within the promoter area of PAI 1 has been described that modifies PAI 1 expression and consequently plasminogen activation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Monoclonal aCL in the presence of beta 2GPI also increased the activity of plasminogen activator inhibitor ( PAI ) 1 in the mixture of tissue plasminogen activator ( t PA ) and PAI 1 by inhibiting the function of beta 2GPI , which increased the remaining t PA activity in the mixture . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fasting levels of blood glucose , plasma lipids and lipoproteins , fibrinogen and plasminogen activator inhibitor ( PAI ) 1 were measured . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To evaluate the most effective factor in the invasion , metastasis and prognosis of hepatocellular carcinoma ( HCC ) , we examined urokinase type plasminogen activator ( uPA ) , plasminogen activator inhibitor ( PAI ) 1 , PAI 2 and uPA activity by enzyme linked immunosorbent assays ( ELISA ) in HCC tissues obtained from 46 patients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
High amounts of p 185 were significantly associated with a high expression of urokinase type plasminogen activator ( uPA ) ( P < . 010 ) , uPA receptor ( P = . 030 ) , type 1 plasminogen activator inhibitor ( PAI ) ( P < . 010 ) , type 2 PAI ( P = . 021 ) , cathepsin D ( P = . 036 ) , matrix metalloproteinase 2 ( P = . 024 ) , alpha 1 antichymotrypsin ( P = . 025 ) , and alpha 2 macroglobulin ( P = . 017 ) . ^^^ Multivariate analysis considering these proteases / protease inhibitors , in addition to alpha 1 antitrypsin , tissue plasminogen activator , plasminogen , alpha 2 antiplasmin , and antithrombin 3 , and established prognostic parameters revealed that , in addition to surgical curability , pT stage , pN stage , and PAI 1 , c erbB 2 is an independent prognostic factor for overall survival of curatively resected patients ( n = 139 ; P = . 049 ; relative risk , 1 . 54 ; 95 % confidence interval , 1 . 08 to 1 . 67 ) and all patients ( P = . 028 ; relative risk 1 . 33 ; 95 % CI , 1 . 28 to 1 . 38 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
It has become more and more clear in recent decades that the plasminogen activation system , which includes urokinase type plasminogen activator ( uPA ) , urokinase type plasminogen activator receptor ( uPAR ) , plasminogen activator inhibitor ( PAI ) 1 and PAI 2 , plays a very important role in the aggressiveness of cancer . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The secreted levels of the protein plasminogen activator inhibitor ( PAI ) was found to be significantly reduced in SV 40 transfected cells when compared to untransfected controls . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To explore the effects of Pravastatin on the changes of plasminogen activator inhibitor 1 ( PAI 1 ) gene expression of hepatic tissue in rabbit with fatty liver . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor ( PAI ) 1 overexpression in retinal microvessels of PAI 1 transgenic mice . ^^^ PURPOSE : Previous studies have suggested that disturbances in plasminogen activator inhibitor ( PAI ) 1 may be relevant to the development of diabetic microvascular complications . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To investigate the underlying mechanisms , we treated glomerular mesangial cells with glucosamine and studied the regulation of the plasminogen activator inhibitor ( PAI ) 1 gene . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Furthermore , EPA E significantly and dose dependently ameliorated coagulation related parameters , including the prothrombin time ( PT ) , activated partial thromboplastin time ( APTT ) , fibrinogen level , and factor 2 , 5 , 7 , 8 , 9 , 10 , 11 , and 12 and antithrombin 3 ( AT 3 ) activities , and fibrinolysis related parameters , including plasminogen , tissue type plasminogen activator ( t PA ) , alpha 2 plasmin inhibitor ( alpha 2 PI ) , and plasminogen activator inhibitor ( PAI ) , and also suppressed ADP or collagen induced platelet aggregation and the cholesterol to phospholipid ( C / P ) molar ratio in platelet membranes at a dose of 0 . 1 g / kg or higher . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Urokinase type plasminogen activator ( uPA ) , uPA receptor ( uPA R ) and inhibitors ( PA 1 1 ) expression in hepatocellular carcinoma in relation to cancer invasion / metastasis and prognosis ] . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) increases in endotoxemia thus possibly cooperating in altering the hemostatic balance in a prothrombotic direction . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
An impaired fibrinolytic function due to elevated plasma levels of plasminogen activator inhibitor ( PAI ) 1 activity or tissue plasminogen activator ( tPA ) antigen is correlated with the development of myocardial infarction ( MI ) in patients with manifest coronary heart disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Epidemiological studies have shown that the haemostatic parameters Fibrinogen ( Fg ) , Factor 7 ( F 7 ) , Factor 8 ( F 8 ) , von Willebrand factor ( vWF ) , Tissue Plasminogen Activator ( t PA ) , Plasminogen Activator Inhibitors ( PAI ) are risk factors / markers of ischemic cardiovascular disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In particular , pravastatin at a dosage of 20 mg / day significantly reduced only fibrinogen levels , while at a dosage of 40 mg / day significantly reduced factor 7 , fibrinogen , prothrombin fragments 1 and 2 , thrombin antithrombin complexes , tissue plasminogen activator antigen ( tPA : Ag ) before venous occlusion ( b . o . ) , inhibitor of plasminogen activator activity ( PAI ) b . o . , PAI activity after occlusion ( a . o . ) , the human autoantibodies against oxidized low density lipoprotein ( LDL ) , and the c fraction of the third component system levels , and significantly increased tPA : Ag a . o . levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma levels of tissue factor ( TF ) , thrombin antithrombin 3 complex , plasminogen activator inhibitor ( PAI ) 1 , tissue plasminogen activator ( t PA ) , beta thromboglobulin , and platelet factor 4 were measured by enzyme linked immunosorbent assay . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The factor 5 ( FV ) G1691A mutation , the prothrombin ( PT ) G20210A variant , the methylenetetrahydrofolate reductase ( MTHFR ) T677T genotype , the plasminogen activator inhibitor ( PAI ) 1 promoter polymorphism , lipoprotein ( Lp ) ( a ) , antithrombin , protein C , and protein S were investigated in 48 childhood patients aged neonate to < 18 years ( median 0 . 5 years ) with spontaneous venous thromboembolism ( SVT ) compared with the carrier status of their first degree family members . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activation potential in the blood is controlled by an equilibrium between plasminogen activators , mainly tissue type plasminogen activator ( t PA ) , and inhibitors , mainly plasminogen activator inhibitor ( PAI ) 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We compared two methods that measure plasminogen activator inhibitor ( PAI ) activity in plasma based on the ability of PAI to inhibit tissue plasminogen activator ( tPA ) or urokinase ( uPA ) in order to determine which method most accurately measures plasma PAI activity after stressors , like hemorrhage . ^^^ However , we measured a 10 fold difference in PAI activity as measured between assays , suggesting that some endogenous plasma constituents ( tPA , uPA , plasminogen or plasmin ) may interfere with the accurate determination of PAI activity . ^^^ However , removing either tPA or plasminogen from the tPA PAI assay unmasked the presence of some endogenous tPA and plasminogen . ^^^ These results suggest that endogenous tPA and plasminogen may interfere with the measurement of plasma PAI activity in the tPA PAI assay after hemorrhage or other stresses . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In this paper we describe the expression of the tissue plasminogen activator ( tPA ) , urokinase type plasminogen activator ( uPA ) , plasminogen activator inhibitor 1 ( PAI 1 ) and the uPA receptor ( uPAR ) , in normal and atheromatous human vascular tissue obtained at coronary and peripheral vascular surgery . tPA , uPA , PAI 1 and uPAR antigens were localised by immunohistochemistry . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Although fragments of the extracellular matrix component hyaluronan induce macrophage production of inflammatory mediators , the effect of hyaluronan on the fibrinolytic mediators plasminogen activator inhibitor ( PAI ) 1 and urokinase type plasminogen activator ( uPA ) is unknown . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Patients with SIRS presented significantly higher values ( p < 0 . 001 ) for factors related to endothelial damage [ von Willebrand factor ( vWF ) , thrombomodulin , tissue plasminogen activator ( t PA ) , and plasminogen activator inhibitor type 1 ( PAI 1 ) antigen ] , hypercoagulability [ prothrombin fragment 1+2 ( F1+2 ) and thrombin antithrombin complexes ( TAT ) ] , and fibrinolysis ( D dimer and PAI activity ) with respect to the control group . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : The expression of uPA , uPAR , the tissue type plasminogen activator , and plasminogen activator inhibitor ( PAI ) 1 and PAI 2 was investigated using reverse transcription followed by polymerase chain reaction and Western blotting . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor type 1 ( PAI 1 ) was measured by an immunoactivity assay and fibrinogen by von Clauss method . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Deprivation of these two amino acids decreased the secretion of urokinase plasminogen activator ( uPA ) and tissue plasminogen activator ( tPA ) while plasminogen activator inhibitor ( PAI ) 1 and 2 were increased in these cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This study used two mutants of tissue type plasminogen activator ( t PA ) with resistance to inhibitors of fibrinolysis to define the contribution of plasminogen activator inhibitor ( PAI ) 1 and alpha 2 antiplasmin ( alpha 2 AP ) to the control of fibrin lysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Retinas were assessed for plasminogen activator inhibitor ( PAI ) 1 mRNA level by RNase protection assay at 1 , 2 , and 3 days after injection and for normal and abnormal blood vessel growth 3 days later . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Antitrombin 3 ( ATIII ) , fibrinogen degradation products ( FDP ) , tissue plasminogen activator ( tPA ) , and plasminogen activator inhibitor ( PAI ) have been evaluated preoperatively and 6 , 12 , 24 and 48 hours after the operation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Baseline levels of tissue plasminogen activator ( tPA ) and plasminogen activator inhibitor 1 ( PAI ) were elevated in eight and 14 patients respectively . tPA increased from 12 . 6 + / 5 . 2 ng / ml to a maximum of 19 . 0 + / 6 . 7 ng / ml at 72 h . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
HbA1c and cardiovascular risk factors were in the same range for IFH and IPH except for active plasminogen activator inhibitor ( PAI ) 1 which was significantly higher in IFH . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The plasminogen activator inhibitor ( PAI ) 1 promoter 4G / 4G genotype is not associated with ischemic stroke in a population of German children . ^^^ OBJECTIVES : To investigate the relationship between an insertion / deletion ( 4G / 5G ) polymorphism of the plasminogen activator inhibitor ( PAI ) 1 gene and childhood patients with a past history of ischemic stroke . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
PURPOSE : To investigate the relationship between the diabetic retinopathy ( DR ) and the activity of plasma tissue plasminogen activator ( tPA ) and plasminogen activator inhibitor ( PAI ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The pathogenesis of antiphospholipid antibody ( aPL ) related thrombosis is multifactorial and includes , amongst others , enhanced coagulation activation measured as prothrombin fragment 1 + 2 ( F 1 + 2 ) , elevated plasma levels of von Willebrand factor ( vWF ) , plasminogen activator inhibitor ( PAI ) and endothelin 1 ( ET 1 ) as well as heightened thromboxane generation and lipid peroxidation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : This study was undertaken to investigate if low dose dietary administration of tannic acid exerts its chemopreventive activity on hepatocarcinogenesis in male C3H mice through changes of plasminogen activator activity ( PAA ) , plasminogen activator inhibition ( PAI ) or plasmin inhibition ( Pl ) in the liver of C3H hepatoma bearing male mice . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The concentrations of tissue plasminogen activator ( tPA ) , urokinase ( uPA ) and plasminogen activator inhibitor 1 ( PAI 1 ) and inhibitor 2 ( PAI 2 ) in bile were measured by enzyme linked immunoassay . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The serpin plasminogen activator inhibitor ( PAI ) type 2 is expressed in differentiated epidermal keratinocytes . ^^^ The effect of PAI 2 on papilloma formation did not appear to involve inhibition of the secreted protease urokinase type plasminogen activator ( uPA ) : PAI 2 accumulated predominantly in cells , and PAI 2 overexpression failed to alleviate a phenotype induced by uPA secretion , as demonstrated by a double transgenic strategy . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Deprivation of these two amino acids decreased the secretion and protein expression of tissue type plasminogen activator ( tPA ) while expression and secretion of plasminogen activator inhibitor ( PAI 1 and PAI 2 ) were increased . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The levels of plasminogen activator inhibitor ( PAI ) 1 increase and plasma adiponectin concentration decreases in obesity leading to the development of vascular disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Concentrations of lipids , lipoproteins , homocysteine , factor 7 , fibrinogen , tissue plasminogen activator ( tPA ) , plasminogen activator inhibitor ( PAI ) 1 , soluble intercellular adhesion molecule ( ICAM ) 1 , P selectin and interleukin ( IL ) 8 were not beneficially affected . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Kaolin partial thromboplastin time ( KPTT ) , prothrombin time ( PT ) , fibrinogen content , vWF content were analyzed , and tissue plasminogen activator ( t PA ) activity , plasminogen activator inhibitor ( PAI ) activity , D dimer level were assayed . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor ( PAI ) 1 is the main inhibitor of the fibrinolytic system and was recently shown to be produced by adipose cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Impedance cardiogram and pheopneumogram , blood gas analysis , mean systemic arterial pressure ( mSAP ) , plasma tissue plasminogen activator ( tpA ) and plasminogen a ctivator inhibitor ( PAI ) activity were examined before and after treatment . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fibrinogen ( Fg ) , antigen level of protein C ( PC ) , plasminogen ( PLG ) activity , alpha ( 2 ) plasminogen inhibitor activity ( alpha ( 2 ) PI ) , and plasminogen activator inhibitor ( PAI ) activity were decreased at diagnosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : Plasminogen activator inhibitor ( PAI ) is a marker of recurrence of myocardial infarction . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To study the distribution and expression of type 1 plasminogen activator inhibitor ( PAI 1 ) and type 2 plasminogen activator inhibitor ( PAI 2 ) in synovial tissue from rheumatoid arthritis ( RA ) and measure the antigen levels and activity in synovial fluid and plasma of patients with RA . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Using the plasminogen activator inhibitor ( PAI ) promoter to drive the expression of a reporter gene ( mouse CD 2 ) , we devised a system to clone negative regulators of the transforming growth factor beta ( TGF beta ) signaling pathway . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We therefore studied extracellular accumulation of histamine , plasminogen activator inhibitor ( PAI ) 1 , vascular endothelial growth factor ( VEGF ) , and interleukin ( IL ) 6 during preparation and storage of various platelet concentrates . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
MEASUREMENT AND MAIN RESULTS : The DIC patients with MOF had more elevated levels of tissue plasminogen activator antigen ( t PA ) and plasminogen activator inhibitor antigen ( PAI ) , and more depressed levels of plasmin alpha 2 plasmin inhibitor complex ( PIC ) and fibrin / fibrinogen degradation products than those without MOF , although no significant difference in thrombin antithrombin complex ( TAT ) levels was observed . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma tissue plasminogen activator ( t PA ) and plasminogen activator inhibitor ( PAI 1 ) activity were measured pre operatively , immediately before and five minutes following aortic clamp release . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The proteins we have measured , using quantitative immunofluorescence , are proteins whose expression is known to be modulated during atherogenesis in humans , including plasminogen activator inhibitor ( PAI ) 1 , transforming growth factor ( TGF ) beta 1 , osteopontin and the macrophage marker CD11b . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
PURPOSE : Urokinase type plasminogen activator ( uPA ) and its inhibitor , plasminogen activator inhibitor ( PAI ) 1 , have been shown to be related to poor prognosis in a variety of malignant solid tumors . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Impairment of the fibrinolytic system , caused primarily by increases in the plasma levels of plasminogen activator inhibitor ( PAI ) type 1 , are frequently found in diabetes and the insulin resistance syndrome . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Independent relationship between microalbuminuria and plasminogen activator inhibitor 1 activity ( PAI 1 ) activity in clinically healthy 58 year old men . ^^^ Urinary albumin excretion was significantly associated with body mass index , systolic and diastolic blood pressure , plasminogen activator inhibitor ( PAI ) 1 activity , tissue plasminogen activator ( tPA ) antigen , tPA activity ( negatively ) and protein S ( P < 0 . 05 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
No correlation between the thrombogenic factor 5 ( G1691A ) , factor 2 ( G20210A ) , methylenetetrahydrofolate reductase ( C677T ) , or the plasminogen activator inhibitor ( PAI ) 1 promotor ( 4G / 5G ) genotypes and the risk of infection with E . coli O 157 : H 7 , or the risk of development of HUS among infected patients , was found . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Inhibition of the fibrinolytic system may occur either at the level of the PA , by specific plasminogen activator inhibitors ( PAI ) , or at the level of plasmin , mainly by alpha 2 antiplasmin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
All the tumours expressed matrix metalloproteinases ( MMP ) 2 and 9 , tissue inhibitor of metalloproteases ( TIMP ) 2 , urokinase plasminogen activator ( u PA ) , plasminogen activator inhibitor ( PAI ) 1 and PAI 2 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To investigate the level of plasma tissue plasminogen activator ( tPA ) , plasminogen activator inhibitor ( PAI ) , 6 keto prostaglandin F 1 alpha ( PGF 1 alpha ) , thromboxane B 2 ( TXB 2 ) , factor 8 related antigen ( 8 R : Ag ) in acute cerebral infarction ( ACI ) patients with different TCM syndrome type and the therapeutical effect of activating blood stasis ( ABS ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
At the cellular level , particulate nickel subsulfide inhibits fibrinolysis by transcriptionally inducing expression of plasminogen activator inhibitor ( PAI ) 1 , an inhibitor of the urokinase type plasminogen activator . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Nickel may promote fibrosis by transcriptionally activating plasminogen activator inhibitor ( PAI ) 1 and inhibiting fibrinolysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
MATERIAL AND METHODS : Uricemia , 24 h uricosuria , serum creatinine , GFR , maximal urinary specific gravity , urokinase activity in the urine , total fibrinolytic activity of the urine ( TFAU ) , activity of plasminogen activator inhibitor ( PAI ) in blood were studied in 33 patients with genetically determined purine metabolism disorders . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Oral HRT use was associated with increased plasma levels of Factor 9 , activated protein C ( APC ) resistance , and CRP ; and with decreased levels of tissue plasminogen activator ( t PA ) antigen and plasminogen activator inhibitor ( PAI ) activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
An association between an increase in plasminogen activator inhibitor type 1 ( PAI 1 ) and obesity , and also between elevated levels of PAI 1 and the presence of PAI 1 promoter 4G allele has been described in adults and can contribute to increased risk of cardiovascular disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : Patients after successful cardiopulmonary resuscitation have been shown to exhibit elevated plasma concentrations of plasminogen activator inhibitor ( PAI ) type 1 , the main circulating antifibrinolytic protein . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : Platelet aggregability was examined on admission and after 2 weeks of treatment in 22 patients with unstable angina , in particular with regard to small sized platelet aggregates , plasma tissue factor ( TF ) antigen levels as a marker of blood coagulation , and plasma plasminogen activator inhibitor ( PAI ) activity levels as an indicator of fibrinolysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Assays for F 1 + 2 , AT levels , TAT complex , APC activity , FPA , D Dimers , tPA , plasminogen , PAI 1 , and PAI 2 are more specific for fibrin formation and lysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In comparison , Ets 1 did not increase Smad3 / TGF beta induced stimulation of the TGF beta responsive plasminogen activator inhibitor 1 ( PAI 1 ) promoter . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : In the present study , tissue plasminogen activator ( t PA ) and its main antagonist plasminogen activator inhibitor 1 ( PAI 1 ) were determined in 12 subjects with normal renal function ( group A ) [ serum creatinine ( Cr ) < 1 . 3 mg / dl ] , 24 patients with impaired renal function ( Cr 1 . 3 6 . 5 mg / dl ) ( group B ) and 22 patients with endstage renal disease ( ESRD ) on hemodialysis ( Cr > 6 . 5 mg / dl ) ( group C ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Indeed in several tumour types , elevated levels of uPA , its receptor ( uPAR ) or its inhibitor plasminogen activator inhibitor 1 ( PAI 1 ) is associated with a poorer prognosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Recent reports suggest that elevated levels of plasminogen activator inhibitor 1 ( PAI 1 ) may contribute to tumour progression . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
When endothelial cells were incubated with LPC ( 2 . 5 micrograms . ml 1 ) for 24 h , the endothelial cells turned round pyknotic , exfoliated and broken , and the contents of malondialdehyde ( MDA ) , lactate dehydrogenase ( LDH ) and plasminogen activator inhibitor ( PAI ) were markedly increased and the superoxide dismutase ( SOD ) activity was inhibited . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We report the arthroscopic treatment of pigmented villonodular synovitis ( PVNS ) in a 13 year old Japanese boy with congenital partial deficiency of plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^ In addition , levels of `` active PAI ' ' in the plasma , which is a measure of total PAI bound to exogenous plasminogen activator , were very low . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
High plasminogen activator inhibitor ( PAI ) 1 levels and poor dietary fat quality are potential risk factors for cardiovascular disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Similarly , the plasminolytic activity was increased and plasminogen activator inhibitor ( PAI ) activity was decreased in supernatants from PI treated cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
MEASUREMENTS : Plasma concentrations of leptin , the inflammatory parameter soluble TNF alpha receptors ( TNFR 55 and TNFR 75 ) , the acute phase proteins lipopolysaccharide binding protein ( LBP ) , serum amyloid A ( SAA ) , alpha acid glycoprotein ( AGP ) , C reactive protein ( CRP ) , plasminogen activator inhibitor 1 ( PAI 1 ) and the anti inflammatory soluble Interleukin 1 decoy receptor ( sIL 1RII ) were measured . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
RESULTS : In the study group , ( 1 ) Levels of triglycerides ( TG ) and low density lipoprotein cholesterol ( LDL C ) decreased and high density lipoprotein cholesterol ( HDL C ) level increased significantly ; ( 2 ) Plasma level of fibronectin ( FN ) and plasminogen activator inhibitor ( PAI ) lowered significantly , plasma antithrombin ( AT 3 ) level unchanged ; ( 3 ) Serum beta 2 microglobulin ( beta 2 MG ) level and urinary level of N acetyl beta D glucosaminidase ( NAG ) and interleukin 6 ( IL 6 ) decreased significantly ; ( 4 ) CD 8 of blood increased , CD4 / CD8 and circulating immune complex ( CIC ) of blood reduced obviously . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
RESULTS : Interleukin 1beta ( IL 1beta ) induced tPA and plasminogen activator inhibitor ( PAI ) 1 mRNA and supernatant tPA antigen were significantly inhibited by both NO donors , which resulted in a net decrease in the IL 1beta evoked tPA enzyme activity in the conditioned media . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The urokinase type plasminogen activator ( uPA ) system is a dynamic complex in which the membrane receptor uPAR binds uPA that binds the plasminogen activator inhibitor ( PAI ) 1 localized in the extracellular matrix , resulting in endocytosis of the whole complex by the low density lipoprotein receptor related protein ( LRP ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Elevated plasma plasminogen activator inhibitor ( PAI ) 1 observed during insulin resistance has been connected with an excessive PAI 1 adipose tissue secretion mainly by visceral fat . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To observe the effect of Yimai Jiangya extract ( YMJYE ) on platelet alpha granule membrane protein ( GMP 140 ) , tissue type plasminogen activator ( t PA ) and its inhibitor ( PAI ) , angiotensin 2 ( AngII ) in aged patients with essential hypertension ( EH ) of stage 2 caused by Qi deficiency and blood stasis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Previous studies demonstrated a relationship between the degree of insulin resistance and plasma plasminogen activator inhibitor type 1 ( PAI 1 ) levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have previously shown that BFD patients had significant lower tissue type plasminogen activator ( t PA ) antigen level and higher plasminogen activator inhibitor , Type 1 ( PAI 1 ) antigen level than normal controls . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Levels of tissue type plasminogen activator ( tPA ) , urokinase type plasminogen activator ( uPA ) , plasminogen activator inhibitor ( PAI ) type 1 ( PAI 1 ) and type 2 ( PAI 2 ) , and tPA / PAI complex in tissue extracts were determinated by commercially available enzyme linked immunosorbent assay kits . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
RESULTS : At diagnosis , plasma levels of P selectin , soluble fibrinomonomer complex ( SFMC ) , thrombomodulin ( TM ) , tissue plasminogen activator , D dimer ( D D ) were significantly elevated , but protein C antigen ( PC : Ag ) , plasminogen ( PLG ) , alpha ( 2 ) antiplasmin ( alpha ( 2 ) PI ) and plasminogen activator inhibitor ( PAI ) were decreased , and fibrinogen ( Fg ) , PC activity ( PC : A ) and protein S ( PS ) were in normal range . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Levels of fibrinogen , factor 7 ( FVII ) , factor 13 ( FXIII ) , plasminogen activator inhibitor ( PAI ) 1 , and tissue plasminogen activator have been associated with coronary artery disease as have genetic polymorphisms . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Renal cortical mRNA of transforming growth factor beta , plasminogen activator inhibitor ( PAI ) 1 , and extracellular matrix started to increase at 14 days and elevated further at 28 days . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In patients with type 2 diabetes , fibrinolysis is considered impaired by increased plasma concentrations of plasminogen activator inhibitor ( PAI ) 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Platelet count , fibrinogen level , prothrombin time , activated partial thromboplastin time , tissue plasminogen activator ( t PA ) activity , plasminogen activator inhibitor ( PAI ) activity , prothrombin fragment ( PF ) 1+2 level , and D dimer level were measured before surgery . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Hyperinvasiveness in both cases resulted from a downregulation of tissue inhibitor of metalloprotease ( TIMP ) 1 and plasminogen activator inhibitor ( PAI ) 1 genes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : Sixty six acute cerebral infarction patients with blood stasis Syndrome , various vascular active factors such as tissue plasminogen activator ( t PA ) , the activity of plasminogen activator inhibitor ( PAI ) , the concentration of prostaglandin F 1 alpha ( 6 keto PGF 1 alpha ) etc . were determined . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The aim of the present study was to determine the level of urokinase plasminogen activator ( uPA ) , plasminogen activator inhibitor type 1 ( PAI 1 ) and plasminogen activator inhibitor type 2 ( PAI 2 ) in normal and malignant tissues of corpus uteri and to evaluate the possible correlation with clinical and histopathological prognostic factors . ^^^ Our results indicate that components of the plasminogen activation cascade are up regulated in endometrial cancer and suggest the role of PAI 2 in determining invasive potential of endometrial carcinomas . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
RESULTS : We found the dose dependent stimulating effect of rHuEPO and rGM CSF on HUVEC proliferation , but we did not achieve this with rG CSF . rHuEPO like rG CSF was an effective agent in stimulating the plasminogen activator inhibitor ( PAI ) 1 release from HUVECs to a cultured medium , while rGM CSF failed . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Abnormalities of haemorheology ( plasma viscosity , fibrinogen ) , endothelial function [ von Willebrand factor ( vWf ) ] , platelet activation ( soluble P selectin ) and thrombogenesis [ plasminogen activator inhibitor ( PAI ) , and fibrin D dimer ] are common in cardiovascular disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the same subjects the following were measured : plasma fibrinogen ( FNG ) , von Willebrand factor ( vWF ) , plasminogen activator inhibitor ( PAI ) , homocysteine ( HC ) , total cholesterol ( CHO ) , triglycerides ( TG ) , high density and low density lipoprotein ( HDL and LDL ) , platelet numbers and aCL of IgG and IgM isotype . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Increased production of plasminogen activator inhibitor 1 ( PAI 1 ) in plaques plays a role in the pathogenesis of atherosclerosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We hypothesized that elevated plasminogen activator inhibitor ( PAI ) 1 promotes ECM deposition in the asthmatic airway by inhibiting MMP 9 activity and fibrinolysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : We examined the role of prostaglandin D 2 ( PGD 2 ) in the formation of plasminogen activator inhibitor ( PAI ) 1 following interleukin 1beta ( IL 1 ) stimulation in bovine endothelial cells ( EC ) transfected with lipocaline type PGD 2 synthase ( L PGDS ) genes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
PURPOSE : The serine proteases tissue plasminogen activator ( t PA ) and urokinase plasminogen activator ( u PA ) and their inhibitor , plasminogen activator inhibitor ( PAI ) 1 , regulate a variety of processes involved in tissue morphogenesis and differentiation . ^^^ CONCLUSIONS : The production of plasminogen activators and PAI 1 by HRGCs reflects the potential role of these cells in the progression of neovascular ocular diseases . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : Plasminogen activator inhibitor 1 ( PAI 1 ) is a main regulator of the fibrinolytic system . ^^^ PAI 1 inhibits tissue plasminogen activator and urokinase type plasminogen activator , resulting in reduced plasminogen activity and attenuated fibrinolysis and proteolysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Metformin also appears to induce cardioprotective effects on serum lipids as well as plasminogen activator inhibitor ( PAI ) 1 and may decrease the risk of development of type 2 diabetes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The result is an exaggeration of the mitogenic actions of insulin leading to vascular smooth muscle proliferation and elevated plasminogen activator inhibitor ( PAI ) 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Blood levels of plasminogen , tissue plasminogen activator ( tPA ) , and plasminogen activator inhibitor ( PAI ) , were measured before and after stress ( 5 minutes of stair climbing ) in a group of 30 women , 23 40 years old , who had taken 30 mcg of ethinyl estradiol with 150 mcg of desogestrel or levonorgestrel for at least 1 year . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Activities and concentrations of tissue plasminogen activator ( tPA ) , plasminogen activator ( PAI ) type 1 , and tPA / PAI complex were determined by ELISA kits . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma fibrinogen , red cell aggregation ( RCA ) , viscosity , factor 7 activity , plasminogen activator inhibitor ( PAI ) activity , tissue plasminogen activator antigen ( t PA ) , plasma cholesterol , triglyceride and insulin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
RESULTS : Expression of matrix metallsoproteinase ( MMP ) 2 , MMP 9 , tissue inhibitor of metalloproteinases ( TIMP ) 1 and urokinase type plasminogen activator ( u PA ) , other than that of TIMP 2 and plasminogen activator inhibitor type ( PAI ) 1 , was observed in normal trophoblastic cells in in vitro culture . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In this study , we examined polymerized collagen regulation of plasminogen activator inhibitor ( PAI ) 1 and its involvement in SMC migration . ^^^ Furthermore , for SMCs cultured on polymerized collagen , platelet derived growth factor stimulated migration on vitronectin is enhanced by PAI 1 , with its function counteracted by urinary plasminogen activator . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Regulation of plasminogen activator inhibitor ( PAI ) 1 expression in a human trophoblast cell line by glucocorticoid ( GC ) and transforming growth factor ( TGF ) beta . ^^^ Plasminogen activator inhibitor ( PAI ) 1 plays a key role in the regulation of fibrinolysis and cellular invasion by virtue of suppression of plasminogen activator function . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Clinical relevance of urokinase type plasminogen activator and its inhibitor type 1 ( PAI 1 ) in squamous cell carcinoma of the uterine cervix . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Median activity of the plasminogen activator inhibitor 1 ( PAI 1 ) and the concentration of TPA PAI 1 complexes were increased to approximately double those in nonsevere haemophiliacs . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor ( PAI ) 1 , tissue type plasminogen activator activity and plasmin antiplasmin complexes ( PAP ) were determined at baseline and after the venous occlusion test . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : Plasma level of plasminogen activator inhibitor ( PAI ) 1 is genetically determined by a polymorphism in the promoter region , involving two alleles , 4G and 5G . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
At each time point , six coagulation parameters ( platelet count , fibrinogen level , factor 7 activity , thrombin antithrombin complex [ TAT ] level , tissue plasminogen activator [ tPA ] activity , and plasminogen activator inhibitor [ PAI ] activity ) were measured as well as all standard blood count parameters . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHOD : Platelet alphagranule membrane protein ( GMP 140 ) , von Willebrand Factor ( vWF ) , antithrombin 3 activity ( AT 3 ) , protein C dependent partial thromboplastin activation time , plasminogen activity ( PLG ) , the activity of tissue type plasminogen activator ( t PA ) and plasminogen activator inhibitor ( PAI ) , D Dimer were examined in 20 normal non pregnant women and 38 patients after operation with gynecological malignancies . ^^^ RESULTS : vWF , GMP 140 , PLG , D Dimer , and PAI of patients with malignancies before operation were obviously higher than those of the healthy women ( P < 0 . 01 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : Fifty seven cases of AICVD were grouped and treated with heparin and Xueshuantong ( XST ) respectively , and the levels of prothrombin time ( PT ) , activated partial thromboplastin time ( APTT ) , fibrinogen ( FIB ) , tissue plasminogen activator ( t PA ) , plasminogen activator inhibitor ( PAI ) and activated protein C ( APC ) were determined before and after treatment . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Changes of tissue plasminogen activator ( t pA ) and plasminogen activator inhibitor activity ( PAI ) as well as the intestinal adhesion were investigated . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We provide evidence that plasminogen activator inhibitor ( PAI ) 1 can detach cells by disrupting uPAR VN and integrin VN interactions and that it does so by binding to the uPA present in uPA uPAR integrin complexes on the cell surface . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma levels of hemoglobin A1c ( HbA1c ) , insulin , fibrinogen , plasminogen activator inhibitor ( PAI ) and thrombomodulin were significantly high in KK and KK Ay mice compared with age matched non diabetic mice ( ddY mice ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Because TGF beta reduces the activity of MMPs through increasing plasminogen activator inhibitor ( PAI ) 1 , we tested whether BMP 7 interferes with this TGF beta effect . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In acute anti thy 1 GN , untreated nephritic rats showed marked mesangial cell lysis and induced nitric oxide production at day 1 and high proteinuria , glomerular matrix accumulation , and transforming growth factor ( TGF ) beta ( 1 ) , fibronectin , and plasminogen activator inhibitor ( PAI ) 1 expression at day 7 after disease induction , respectively . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
INTERVENTIONS : The prothrombotic response to cardiac surgery with CPB was assessed by measuring plasma levels of prothrombin fragment 1 + 2 and plasminogen activator inhibitor ( PAI ) activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : Although acceleration of plasma plasminogen activator inhibitor 1 ( PA 1 ) level after emergent coronary angioplasty in acute myocardial infarction ( AMI ) has been documented , its pathophysiologic role is still unknown . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHOD : Plasma was obtained from 29 patients with SSc and tested for thrombin antithrombin ( TAT ) , fragments 1+2 ( F1+2 ) , dermatansulphate ( DS ) , thrombomodulin ( TM ) , lipoprotein ( a ) [ Lp ( a ) ] , von Willebrand factor ( vWF ) , tissue type plasminogen activator ( tPA ) , plasminogen activator inhibitor ( PAI ) , D dimers , intercellular adhesion molecole 1 ( ICAM 1 ) , vascular cell adhesion molecule ( VCAM ) , and E selectin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Patients with hypercholesterolemia and with coronary atherosclerosis have increased plasma levels of plasminogen activator inhibitor ( PAI ) 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fibrinolytic capacity is diminished during pregnancy , mainly because of markedly increased levels of plasminogen activator inhibitor 1 ( PAI 1 ) from endothelial cells and plasminogen activator inhibitor 2 ( PAI 2 ) from the placenta . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
After adjustments for age in FDR , adiponectin levels were negatively correlated with fasting proinsulin ( r 0 . 64 , P < 0 . 001 ) , plasminogen activator inhibitor ( PAI ) 1 activity ( r 0 . 56 , P < 0 . 001 ) , fasting insulin ( r 0 . 55 , P < 0 . 001 ) , and acute insulin response ( r 0 . 40 , P < 0 . 05 ) ; they were positively related to HDL cholesterol ( r 0 . 48 , P < 0 . 01 ) and S ( 1 ) ( r 0 . 41 , P < 0 . 01 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BMI was calculated , and the following measurements were taken : International Normalized Ratio , antithrombin 3 , tissue plasminogen activator ( t PA ) activity , t PA antigen , plasma fibrinogen level , factor 7 , Plasminogen activator inhibitor ( PAI ) 1 activity and antigen and metabolic parameters : fasting insulin and glucose , total cholesterol , HDL cholesterol , LDL cholesterol and triglycerides . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator ( PA ) and plasminogen activator inhibitor ( PAI ) are involved in many physiological or pathological events . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To detect the expression of urokinase type plasminogen activator ( uPA ) and its inhibitors ( plasminogen activator inhibitors , PAI ) type 1 and type 2 in squamous cell carcinoma of human larynx and reveal the correlation of the major clinicopathologicl parameters and prognosis . ^^^ PAI 1 might act as an essential modulator of the plasminogen activation system or a protector of carcinoma tissue against self degradation rather than as a simple inhibitor of system . uPA and PAI 2 could be new independent and strong biologically prognostic factors . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Images were analysed quantitatively from tissue sections stained for collagen ( Masson trichrome ) , fibrin ( Verhoeff ' s stain ) and elastin ( Hart ' s stain ) , and immunostained for TGF beta 1 , inducible nitric oxide synthase ( iNOS ) , heme oxygenase 1 ( HO 1 ) , alpha smooth muscle actin ( ASMA ) , apoptosis ( TUNEL ) and plasminogen activator inhibitor ( PAI ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : To examine the platelet alphagranule membrane protein ( GMP 140 ) , Von Willebrand factor ( vWF ) , antithrombin 3 activity ( AT 3 ) , plasminogen activity ( PLG ) , the activity of tissue type plasminogen activator ( t PA ) and plasminogen activator inhibitor ( PAI ) in 30 non pregnancy women , 30 normal late pregnancy women and 50 pregnancy induced hypertension women . ^^^ RESULTS : In PIH group vWF [ ( 156 + / 23 ) % ] , GMP 140 [ ( 23 . 9 + / 3 . 6 ) microg / L ] , Fbg [ ( 15 . 5 + / 0 . 8 ) g / L ] , PLG [ ( 141 + / 9 ) % ] , D Dimer [ ( 1 . 42 + / 0 . 32 ) mg / L ] , PAI [ ( 9 . 2 + / 0 . 8 ) kU / L ] were obviously higher than those of control group . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
For testing fibrinolysis , determinations of plasmin alpha ( 2 ) antiplasmin complex ( PAP ) , tissue type plasminogen activator ( tPA ) antigen , plasminogen activator inhibitor ( PAI ) 1 antigen and D dimer were used . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The aim of the present study was to investigate whether epidermal growth factor receptor ( EGF R ) , tissue plasminogen activator ( tPA ) , and plasminogen activator inhibitor ( PAI ) are involved in this process . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fibrinolytic system parameters , plasminogen , tissue type plasminogen activator ( t PA ) and urokinase PA , PA inhibitor type 1 ( PAI 1 ) and PAI type 2 concentrations and PAI 1 activity , were quantified in plasma and pleural fluid . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The levels of plasminogen activator inhibitor ( PAI ) 1 activity , uPA antigen and factor ( F ) XIIa did not significantly differ between the patient groups and healthy controls . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Angiogenesis related genes that showed aberrant expression level are matrix metalloproteinase 2 ( MMP 2 ) , plasminogen activator inhibitor ( PAI ) , integrin , transforming growth factor beta ( TGF beta ) , vascular endothelial growth factor ( VEGF ) , basic fibroblast growth factor ( bFGF ) , and leptin receptor . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Relatively weak and variable tumor cell staining was found for plasminogen activator inhibitors ( PAI ) 1 , 2 , and 3 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Levels of tissue plasminogen activator ( TPA ) antigen , D dimer , and activity of plasminogen activator inhibitor ( PAI ) were measured before and in 24 hours , 3 , 7 , 14 days after randomization . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : The aim of this study was to determine ( a ) if alpha 2 antiplasmin , plasminogen and plasminogen activator inhibitors ( PAI 1 4 ) change in the peripartal period , ( b ) if these changes are explainable by the detachment of the placenta and the release of coagulation factors , and ( c ) if aprotinin could affect postpartal fibrinolysis when given shortly before delivery . ^^^ The results of PAI ( 1 4 ) , alpha 2 antiplasmin and plasminogen were collected shortly before and after delivery and 30 and 120 min after detachment of the placenta . ^^^ RESULTS : Normal deliveries and cesarean sections without aprotinin showed an evident decrease of PAI ( 1 4 ) after delivery while alpha 2 antiplasmin and plasminogen values did not change . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Aldosterone enhances angiotensin 2 ( Ang 2 ) induced plasminogen activator inhibitor ( PAI ) 1 expression in vitro . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The allograft microenvironment was examined using immunohistochemistry for fibrogenic markers ( transforming growth factor [ TGF ] beta , platelet derived growth factor [ PDGF ] , tissue plasminogen activator [ TPA ] , plasminogen activator inhibitor [ PAI ] 1 , matrix metalloproteinase [ MMP ] 2 , and tissue inhibitor of matrix metalloproteinase [ TIMP ] 2 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We analysed three polymorphisms located at the BACE 1 gene , one polymorphism at the ACHE gene , and two variants located at the tissue plasminogen activator and plasminogen activator inhibitor 1 ( genes TPA and PAI 1 , respectively ) , both part of the plasmin system . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In this paper , we have studied the contribution of the plasminogen activation system in the development of atherosclerosis by cross breeding apoE 3 Leiden mice , which have a human like lipid profile , with mice deficient in PAI 1 ( plasminogen activator inhibitor 1 ) , u PA ( urokinase plasminogen activator ) , and t PA ( tissue plasminogen activator ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS AND RESULTS : We studied in prediabetic individuals from the Insulin Resistance Atherosclerosis Study ( IRAS ) the relation of C reactive protein ( CRP ) , plasminogen activator inhibitor ( PAI ) 1 , and fibrinogen to defects in insulin sensitivity ( SI ) and first phase insulin secretion , respectively , as assessed using a frequently sampled intravenous glucose tolerance test . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Endothelial derived plasminogen activator inhibitor ( PAI ) is essential for the regulation of fibrinolysis and impaired endothelial function leads to imbalance in fibrinolysis , resulting in a procoagulant state . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
PATIENTS AND METHODS : The in vivo effect of PGE 1 on the fibrinolytic and hemostatic process was tested on 15 patients before and after treatment with Alprostadil for 21 days using D dimers ( DD ) , fibrinogen , prothrombin time ( PT ) , partial thromboplastin time ( PTT ) , antithrombin ( AT ) , ProC Global , plasminogen , plasminogen activator inhibitor activity ( PAI ) , alpha 2 antiplasmin , coagulation factor 12 , basal and activated fibrinolytic capacity ( fib . cap . ) . ^^^ RESULTS : There was no significant difference in DD , fibrinogen , PT , PTT , AT , ProC Global , plasminogen , PAI , alpha 2 antiplasmin , coagulation factor 12 , basal and activated fibrinolytic capacity observed after the treatment . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To detect single nucleotide polymorphisms ( SNPs ) in codon region of plasminogen activator inhibitor 1 ( PAI 1 ) gene and associate them with development of coronary artery disease ( CAD ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
It has been also shown to enhance fibrinolysis by inhibiting plasminogen activator inhibitor ( PAI ) activity in vitro . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator ( urinary plasminogen activator , urokinase ) ( uPA ) and its PA 1 type 1 inhibitor are not only prognostically but also predictively significant and support clinical decisions on therapy in primary carcinoma of the breast ] . uPA and PAI 1 are the first novel tumor biological prognostic factors in breast cancer for which the prognostic impact has been validated at the highest level of evidence and hence all evaluation criteria for transfer into clinical practice have been fullfilled . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor ( PAI ) activity was elevated in rats fed the fish oil diet . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Levels of D dimer ( DD ) , thrombin antithrombin complex ( TAT ) , prothrombin fragment 1+2 ( F1+2 ) , von Willebrand factor ( vWF ) , fibrinogen , tissue plasminogen activator ( TPA ) and activity of its inhibitor ( PAI ) , soon after start of treatment with heparins and in 1 , 3 , 7 and 14 days . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The aim of this study was to determine the in hospital mortality rate in subjects with shortened aPTTs and the effects of polymorphism in plasminogen activator inhibitor ( PAI ) , t PA and factor 13 gene on the coagulation status . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Levels of plasminogen activator ( PA ) and PA inhibitor ( PAI ) were determined by enzyme immunosorbent assays . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Findings in earlier studies conducted in the authors ' laboratory have suggested that angiostatic steroids suppress the PA activity essential for the invasive aspect of angiogenesis by increasing synthesis of plasminogen activator inhibitor ( PAI ) 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator activity ( PAA ) increased , whereas plasminogen activator inhibition ( PAI ) and plasmin inhibition ( PI ) decreased in proportion to the degree of inflammation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The following fibrinolytic parameters were measured : tissue type plasminogen ( t PA ) antigen and activity , plasminogen activator inhibitor 1 ( PAI 1 ) antigen and activity , and euglobulin clot lysis time ( ECLT ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Since PCI itself did not affect the proliferation rate of Caki 1 cells or cell expression of uPA in vitro , the effect of uPA , PCI , heat inactivated PCI and plasminogen activator inhibitor ( PAI ) 1 on the invasive potential of cultured RCC cells was evaluated . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
INTERVENTIONS : We characterized the expression of tissue type and urokinase type plasminogen activator ( t PA and u PA ) as well as plasminogen activator inhibitor ( PAI ) 1 and PAI 2 in human endothelial cells ( EC ) from the microvascular pulmonary circulation ( HMVEC L ) and compared it with that of EC from pulmonary artery ( HPAEC ) and umbilical vein ( HUVEC ) under baseline conditions and upon stimulation with either tumor necrosis factor alpha or lipopolysaccharide . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor ( PAI ) 1 is the main inhibitor of the fibrinolytic system and is known to play an essential role in tissue remodeling . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We investigated the relationship between the incidence of ONFH and polymorphisms in the genes for plasminogen activator inhibitor ( PAI ) 1 , which is one of the major regulatory proteins of the fibrinolytic system , and 5 , 10 methylenetetrahydrofolate reductase ( MTHFR ) , which is associated with the plasma levels of homocysteine in Japanese subjects . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Expression of plasminogen activator inhibitor ( PAI ) 1 was elevated in TNF alpha treated EVT , and adding antibodies that inhibit PAI 1 activity restored migration , whereas tissue inhibitor of metalloproteinases 1 blocking antibodies were ineffective . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Increased plasma levels of plasminogen activator inhibitor ( PAI ) are associated with myocardial infarction and atherosclerosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue sections from the penis , abdominal aorta , femoral and brachial arteries were stained for collagen , SMC , iNOS , ROS plasminogen activator inhibitor ( PAI ) and apoptosis , and evaluated by quantitative image analysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS AND RESULTS : To examine the effects of nicorandil on endogenous fibrinolysis , plasma concentrations of tissue type plasminogen activator ( t PA ) antigen , type 1 plasminogen activator inhibitor ( PAI 1 ) antigen and PAI activity were measured in consecutive 11 patients ( 7 men and 4 women , mean age 63 years , ranges 41 84 years ) with coronary artery disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Previous studies indicated that the gastric hormone gastrin , which may be increased in H . pylori infection , stimulates gastric expression of plasminogen activator inhibitor ( PAI ) 2 , which is an inhibitor of the urokinase plasminogen activator and has previously been shown to be increased in gastric adenocarcinoma . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
By using immunohistochemistry and real time quantitative polymerase chain reaction techniques , the genetic and proteic analyses were performed on the urokinase type plasminogen activator ( u PA ) , its receptor ( u PAR ) and its inhibitor ( PAI 1 ) , which have been described to be frequently implicated in the process of degradation of the extracellular matrix during the metastatic process . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Repeated measurements of estradiol , progesterone , prothrombin time ( PT ) expressed as INR , activated partial thromboplastin time ( APTT ) ratio , fibrinogen ( FBG ) , factor 8 ( FVIII ) , normalized activated protein C ratio ( nAPC ratio ) , antithrombin 3 activity ( AT ) , protein C activity ( PC ) , protein S activity ( PS ) , tissue type plasminogen activator antigen ( t PA ) , type 1 plasminogen activator inhibitor ( PAI ) , prothrombin fragments 1+2 ( F1+2 ) , were performed during both hyperstimulated and natural cycles , and at onset of the following menstruation or at 8 weeks of pregnancy . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fibrinogen levels , plasminogen activator inhibitor 1 ( PAI 1 ) antigen , PAI 1 activity and thrombin activatable fibrinolytic inhibitor ( TAFI ) antigen levels were measured in each individual of the four groups . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Recent reports suggest that elevated levels of plasminogen activator inhibitor ( PAI ) 1 may contribute to tumor progression . ^^^ XR 5967 , a diketopiperazine , dose dependently inhibited the activity of human and murine PAI 1 , towards urokinase plasminogen activator ( uPA ) , with IC 50 values of 800 nM and 8 . 3 microM , respectively . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Average tissue plasminogen activator ( tPA ) levels were significantly lower in the HAC group by 30 min on CPB ( P < 0 . 05 ) , resulting in preservation of plasminogen activator inhibitor ( PAI ) 1 during CPB ( P < 0 . 05 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : The following polymorphisms were analyzed by sequencing on chip technology using solid phase polymerase chain reaction on oligonucleotide microarrays : factor 5 ( F 5 ) Leiden , factor 2 ( F 2 ) prothrombin G20210A , plasminogen activator inhibitor ( PAI ) 1 4G / 5G , nitric oxide synthase ( NOS ) 3 T768C , NOS 3 Glu298Asp , angiotensinogen ( AGT ) Met235Thr , estrogen receptor ( ER ) alpha Pvu 2 , and mineralcorticoid receptor ( MLR ) Ser810Leu . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
On day 6 , parameters of glomerular repair [ glomerular matrix score , expression of transforming growth factor ( TGF ) beta 1 , fibronectin , and plasminogen activator inhibitor ( PAI ) 1 ] and thrombosis ( aneurysm formation and fibrinogen deposition ) were determined . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We previously demonstrated that thrombin may induce proximal tubular epithelial cells ( PTEC ) proliferation and regulate , through plasminogen activator inhibitor ( PAI ) 1 and urokinase type plasminogen activator ( u PA ) , their profibrotic activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We also report the up regulation of Vascular Cell Adhesion Molecule 1 ( VCAM ) and Plasminogen Activator Inhibitor ( PAI ) 1 after Mg deficiency . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
TGF beta 1 also downregulated urokinase type plasminogen activator ( uPA ) activity while upregulating PA inhibitor ( PAI ) 1 and thrombospondin ( TSP ) 1 gene expression . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The majority of previous factor analyses , however , have used only surrogate measures of insulin sensitivity ; very few have included nontraditional cardiovascular disease ( CVD ) risk factors such as plasminogen activator inhibitor ( PAI ) 1 , fibrinogen , and C reactive protein ( CRP ) ; and only a limited number have assessed the ability of factors to predict type 2 diabetes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
RESEARCH DESIGN AND METHODS : Insulin sensitivity ( through a frequently sampled intravenous glucose tolerance test ) and plasma concentrations of ultrasensitive C reactive protein ( CRP ) , adiponectin , plasminogen activator inhibitor ( PAI ) 1 , tumor necrosis factor alpha , leptin , and interleukin 6 were measured in 89 pGDM ( BMI 26 . 9 + / 0 . 5 kg / m ( 2 ) , age 32 + / 0 . 5 years ) and in 19 women with normal glucose tolerance during pregnancy ( NGT ) ( 23 . 7 + / 0 . 9 kg / m ( 2 ) , 31 + / 1 . 3 years ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Net fibrinolytic activity in plasma reflects the balance between tissue type plasminogen activator and plasminogen activator inhibitor ( PAI ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Cardiac expressions of plasminogen activator inhibitor ( PAI ) 1 , the major physiologic inhibitor of fibrinolysis , and transforming growth factor ( TGF ) beta ( 1 ) , a prototypic profibrotic molecule , were determined and extent of perivascular coronary fibrosis was measured . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
During inflammatory lung injury , the fibrinolytic activity that is normally present within bronchoalveolar lavage ( BAL ) fluid ( BALF ) is often suppressed due to increased levels of inhibitors , including plasminogen activator inhibitor ( PAI ) 1 . ^^^ PAI 1 deficient mice that are protected from bleomycin induced fibrosis had preserved plasminogen activator activity in BALF and increased tissue activity , as determined by in situ zymography . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Young AMI could be also caused by a reduction of the fibrinolytic activity , as it was found when the allele 4G in the promoter of plasminogen activator inhibitor ( PAI ) gene is present . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Treatment with all four OCs caused an increase in levels of fibrinogen , prothrombin fragment 1+2 , D dimer , plasminogen , plasmin antiplasmin complex and an increase in protein C activity , a decrease in antithrombin activity , tissue plasminogen activator ( t PA ) and plasminogen activator inhibitor ( PAI ) , and a slight decrease in the sensitivity to activated protein C , but no significant change in that of the thrombin antithrombin complex . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The plasminogen activator inhibitor 1 ( PAI 1 ) expression can be enhanced by hypoxia and other stimuli leading to the mobilization of intracellular calcium . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The target extracellular matrix ( ECM ) degradation generated by plasminogen activator ( PA ) and regulated by plasminogen activator inhibitor ( PAI ) is an event that affects a wide variety of physiological and pathological processes in the ovary . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We assessed adiponectin , tissue factor pathway inhibitor ( TFPI ) , plasminogen activator inhibitor ( PAI 1 ) , thrombin activatable fibrinolysis inhibitor , and endothelial function / injury markers : von Willebrand factor , thrombomodulin , vascular cell adhesion molecule ( VCAM ) , intercellular adhesion molecule , and CD146 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The release of urokinase type plasminogen activator ( uPA ) and plasminogen activator inhibitor 1 ( PAI ) by GEC or whole glomeruli was assessed by ELISA , fibrin zymography and Northern blot . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In this study we investigated the role of interleukin ( IL ) 12 in regulating trophoblast invasion and the expression of trophoblast proteases ( matrix metalloprotease ( MMP ) 2 , MMP 9 , and urokinase type plasminogen activators ) and their inhibitors ( tissue inhibitors of metalloprotease ( TIMP ) 1 , TIMP 2 , and plasminogen activator inhibitor ( PAI ) 1 ) using an in vitro tissue culture system of human choriocarcinoma cell line JEG 3 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To investigate the effect of a dietary intervention to reduce body weight on red cell aggregation ( RCA ) , factor 7 activity , plasminogen activator inhibitor ( PAI ) activity , tissue plasminogen activator ( t PA ) antigen , fibrinogen , whole blood and plasma viscosity , haematocrit and lipids . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Specifically , overexpression of SRF in human lung fibroblasts upregulated urokinase type plasminogen activator ( uPA ) and its substrate Plg , whereas it downregulated plasminogen activator inhibitor ( PAI ) 1 . ^^^ To determine whether uPA , Plg , and PAI 1 were abnormally expressed in LAM in vivo , we immunostained 12 LAM cases . ^^^ Microdissection based reverse transcriptase / polymerase chain reaction further confirmed upregulation of uPA and Plg and downregulation of PAI 1 message in LAM . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHOD : In a consecutive series of 127 patients resected for primary squamous cell carcinoma of human larynx , the expression of uPA and plasminogen activator inhibitors ( PAI ) type 1 , type 2 was determined immunohistochemically . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In addition , other components commonly aggregate with the major components : elevated apolipoprotein B , small LDL particles , insulin resistance and hyperinsulinemia , impaired glucose tolerance ( IGT ) , elevated C reactive protein ( CRP ) , and variation in coagulation factors ( plasminogen activator inhibitor [ PAI ] 1 and fibrinogen ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Platelet count , fibrinogen , clotting times , prothrombin fragment ( PF ) 1+2 , and tissue plasminogen activator ( t PA ) and plasminogen activator inhibitor ( PAI ) activities were measured preoperatively , immediately before , and 5 min and 24 hr after aortic declamping . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We examined the effect of homocysteine lowering by B vitamin supplementation on tissue plasminogen activator ( tPA ) , plasminogen activator inhibitor type 1 ( PAI ) and von Willebrand factor ( vWf ) markers of endothelial dysfunction in hyperhomocysteinemic and normohomocysteinemic volunteers . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To test the hypothesis that pharmacological plasminogen activator inhibitor ( PAI ) 1 inhibition protects against renin angiotensin aldosterone system induced cardiovascular injury , the effect of a novel orally active small molecule PAI 1 inhibitor , PAI 039 , was examined in a mouse model of angiotensin ( Ang ) 2 induced vascular remodeling and cardiac fibrosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Because each of these processes is regulated by plasminogen activator inhibitor ( PAI ) 1 , we selectively down regulated PAI 1 mRNA in the adult heart to examine the effects on postinfarct neovascularization and myocardial function . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In addition , coagulation factors such as increased levels of tissue factor ( TF ) , van Willebrand factor ( vWF ) and plasminogen activator inhibitor ( PAI ) 1 are important in both , RA and CAD . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : The goal of the present study was to determine , in the three genotypes of the plasminogen activator inhibitor ( PAI ) 1 gene polymorphism , the gender adjusted difference in the relationships between age and PP in subjects with never treated essential hypertension . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Inflammatory markers ( tumour necrosis factor alpha , interleukin 8 , polymorphonuclear elastase ) , fibrinolytic system variables ( tissue plasminogen activator ( PA ) , urokinase PA ( u PA ) , plasminogen activation inhibitor ( PAI ) 1 , PAI 2 ) , and several MMPs ( MMP 1 , MMP 2 , MMP 8 , MMP 9 ) and TIMPs ( TIMP 1 , TIMP 2 ) were determined by ELISA in plasma and pleural fluid . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
On the other hand , plasminogen activator inhibitor 1 ( PAI 1 ) and tissue plasminogen activator ( tPA ) are two important mediators of fibrinolysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Increased levels of tPA , uPA , uPA receptor ( uPAR ) , and their inhibitor , plasminogen activator inhibitor ( PAI ) 1 , have been found in the cerebrospinal fluid ( CSF ) of patients with bacterial meningitis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The content of plasma nitric oxide ( NO ) , and activities of tissue type plasminogen activator ( t PA ) , and plasminogen activator inhibitor ( PAI ) were detected after the hormone was injected for 4 and 8 weeks and after the drugs were given for 4 weeks . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue type plasminogen activator ( t PA ) , plasminogen activator inhibitor ( PAI ) , fibrinogen ( Fbg ) and D dimer ( DD ) were investigated after those rabbits had been treated . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma plasminogen activator inhibitor 1 ( PAI ) antigen , fibrinogen , factor 7 , cholesterol , triglyceride ( TG ) and glucose were determined in 101 healthy subjects , who were divided into 10 subgroups according to age and smoking status . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
RESULTS : In the cross sectional study , we confirm prior positive correlations of adiponectin with HDL and negative correlations with BMI , triglycerides , C reactive protein ( CRP ) , and plasma activator inhibitor ( PAI ) 1 and report a negative correlation with tissue plasminogen activator . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
MEASUREMENTS AND RESULTS : After animals were killed , we measured D dimers , plasminogen activator inhibitor ( PAI ) 1 , and tumor necrosis factor alpha in the bronchoalveolar lavage fluid and calculated lung weight and pressure / volume ( P / V ) plots . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Northern blot analyses confirmed that Etk activation led to induction of steady state mRNA levels of endogenous VEGF and plasminogen activator inhibitor ( PAI ) 1 , a hallmark of hypoxia mediated gene regulation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Levels of plasminogen activity , uPA , tissue plasminogen activator ( tPA ) , and their inhibitor , plasminogen activator inhibitor type 1 ( PAI 1 ) were measured in tears and plasma of patients with VKC . ^^^ CONCLUSIONS : Increased expression of fibrinolytic system components and imbalance between plasminogen activators and PAI may be involved in the pathogenesis of severe allergic conjunctivitis , thus contributing to inflammatory cell migration and tissue remodeling . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
At the same time , increased Plasminogen Activator Inhibitor ( PAI ) 1 secretion has been reported to correlate with fibrotic changes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The increased plasma plasminogen activator inhibitor ( PAI ) activity seen in the LPS group was significantly suppressed in the groups receiving UK ( especially higher dose of UK ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
RESULTS : Markers for inflammation ( interleukin ( IL ) 6 , C reactive protein ( CRP ) ) , thrombosis ( fibrinogen , low molecular weight ( LMW ) fibrinogen , factor 7 , viscosity ) , fibrinolysis ( fibrinolytic activity , plasminogen activator inhibitor ( PAI ) ) , endothelial / platelet activity ( P selectin , von Willebrand factor ( vWf ) ) and oxidative stress ( antibody to oxidized low density lipoprotein ( LDL ) , advanced glycated end products ) were significantly different from a healthy control population . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In patients and 133 age matched healthy controls prothrombotic risk factors ( factor 5 ( FV ) G1691A , factor 2 ( FII ) G20210A , MTHFR T677T , 4G / 5G plasminogen activator inhibitor ( PAI ) 1 , lipoprotein ( Lp ) ( a ) , protein C ( PC ) , protein S ( PS ) , antithrombin ( AT ) , antiphospholipid / anticardiolipin ( APA / ACA ) antibodies ) as well as associated environmental conditions ( smoking and obesity ) were investigated . 70 ( 52 . 6 % ) of the patients had at least one prothrombotic risk factor compared with 26 control women ( 19 . 5 % ; p < 0 . 0001 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Significant improvement in plasminogen activator inhibitor ( PAI ) 1 was present in the rosiglitazone group after 9 months ( p < 0 . 05 ) , and significant PAI 1 improvement was observed in the glimepiride and rosiglitazone groups after 12 months ( p < 0 . 05 and p < 0 . 01 , respectively ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
For example , testosterone treatment is reported to reduce serum levels of the pro inflammatory cytokines interleukin ( IL ) 1beta and tumor necrosis factor ( TNF ) alpha , and to increase levels of the anti inflammatory cytokine IL 10 ; to reduce vascular cell adhesion molecule ( VCAM ) 1 expression in aortic endothelial cells ; to promote vascular smooth muscle and endothelial cell proliferation ; to induce vasodilatation and to improve vascular reactivity , to reduce serum levels of the pro thrombotic factors plasminogen activator inhibitor ( PAI ) 1 and fibrinogen ; to reduce low density lipoprotein cholesterol ( LDL C ) ; to improve insulin sensitivity ; and to reduce body mass index and visceral fat mass . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
AIM : The aim of this study was to observe the effect of a Chinese medicine compound Changtong oral liquid ( CT ) on tissue plasminogen activity ( t PA ) , plasminogen activator inhibitor ( PAI ) , TGF beta 1 and hydroxyproline ( OHP ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We ascertained genotypes for interleukin ( IL ) 6 174 G / C , beta fibrinogen 455 G / A , plasminogen activator inhibitor ( PAI ) 1 675 4G / 5G , and thrombin activatable fibrinolysis inhibitor ( TAFI ) 438 G / A in 2224 men and women > or = 65 years old at baseline . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
FXIII and fibrinogen were measured by functional assays : IgG anticardiolipin antibody ( aCL ) , IgG anti beta 2 glycoprotein 1 ( anti beta 2 GPI ) , and plasminogen activator inhibitor ( PAI ) by immunoassay ; and paraoxonase activity by paranitrophenol formation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Intranasal OVA challenge after sensitization by i . p . administration of OVA induced a higher level of excess subepithelial collagen deposition in wild type ( WT ) C57BL / 6J mice than in plasminogen activator inhibitor ( PAI ) 1 deficient ( PAI 1 ( / ) ) mice . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The results showed that cyanidin 3 glucoside and cyanidin 3 rutinoside treatments could decrease the expressions of matrix matalloprotinase 2 ( MMP 2 ) and urokinase plasminogen activator ( u PA ) in a dose dependent manner and enhance the expression of tissue inhibitor of matrix matalloprotinase 2 ( TIMP 2 ) and plasminogen activator inhibitor ( PAI ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The functions of plasminogen activator inhibitor 1 : do we have all the pieces of PAI . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Prothrombin fragment ( PTF ) 1 + 2 and plasminogen activator inhibitor ( PAI ) activity were measured , and levels correlated with postoperative measures of organ function including the left ventricular stroke work index , the Pao ( 2 ) / fraction of inspired oxygen ( Fio ( 2 ) ) ratio , and creatinine levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
On the 14th day adhesions were evaluated and tissue plasminogen activator ( tPA ) , urokinase plasminogen activator ( uPA ) , plasminogen activator inhibitor ( PAI ) type 1 and 2 were measured in peritoneal biopsy specimens . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : The aim of the study was to investigate the effect of functional polymorphisms in promoters of matrix metalloproteinase ( MMP ) 2 , MMP 3 , MMP 9 , MMP 12 and plasminogen activator inhibitor ( PAI ) 1 genes on the growth rate of small abdominal aortic aneurysms ( AAA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor ( PAI ) 1 is the main inhibitor of the fibrinolytic system and is known to play an essential role in tissue remodeling . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To determine whether plasma concentrations of thrombin activatable fibrinolysis inhibitor ( TAFI ) in patients with type 2 diabetes were associated with components of metabolic syndrome ( MS ) , including high sensitivity C reactive protein ( hs CRP ) , plasminogen activator inhibitor ( PAI ) 1 , and LDL cholesterol . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
At 0 and 12 weeks in both the atorvastatin group ( 10 mg / d ; n=17 ) and the no drug group ( n=10 ) , high sensitivity C reactive protein ( hsCRP ) , monocyte chemoattractant protein ( MCP ) 1 , plasminogen activator inhibitor ( PAI ) 1 , and fibrinogen were measured . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) 4G / 5G and angiotensin converting enzyme ( ACE ) I / D gene polymorphisms and fibrinolytic activity in patients with essential hypertension and dyslipidemia ] . ^^^ Prime genetic factors involved in the process are 4G / 5G polymorphism of promoter region coding tissue plasminogen activator inhibitor 1 ( PAI 1 ) and I / D polymorphism for angiotensin converting enzyme ( ACE ) gene . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS AND RESULTS : We determined insulin effect on nitric oxide ( NO ) production and plasminogen activator inhibitor ( PAI ) 1 synthesis in 12 fibroblast strains obtained from skin biopsy samples of 6 insulin sensitive ( IS ) ( clamp M > 7 mg / kg body weight per minute ) and 6 insulin resistant ( IR ) ( clamp M < 5 mg / kg body weight per minute ) healthy volunteers . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Experimental studies demonstrate a direct impact of viral components ( gp 120 , TAT ) on the endothelium , as they lead to expression of adhesion molecules ( intercellular adhesion molecule [ ICAM ] , E selectin ) , a prothrombotic state ( increase of von Willebrand factor , plasminogen activator inhibitor [ PAI ] 1 , tissue plasminogen activator [ t PA ] , tissue factor ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator ( PA ) / plasmin / PA inhibitor ( PAI ) system is involved in ECM degradation and PAI 1 plays a critical role in ECM remodeling in the kidney . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : Forty eight Sprague Dawley ( SD ) rats were randomly divided into the model group , sham operation group , and control group for indexes observation of triphenyltetrazolium chloride ( TTC ) dyeing , neurological deficit , plasma tissue type plasminogen activator ( tPA ) activity , plasminogen activator inhibitor ( PAI ) activity , thromboxane B ( 2 ) ( TXB ( 2 ) ) content , and 6 keto prostaglandin ( 6 keto PGF ( 1alpha ) ) content . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Levels of sputum interleukin ( IL ) 8 , IL 10 , interferon ( IFN ) gamma , tumor necrosis factor ( TNF ) alpha , human cationic antimicrobial protein 18 ( CAP 18 ) , urokinase type plasminogen activator ( uPA ) , uPA receptor ( uPAR ) , and plasminogen activator inhibitor ( PAI ) 1 were determined . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Restoration of collagen degradation by GSH is associated with a reduction of type 1 plasminogen activator inhibitor ( PAI ) 1 expression / activity as well as recovery of the activities of cell / extracellular matrix associated tissue type plasminogen activator and plasmin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fibrinolytic system components ( u PA , u PAR and plasminogen activator inhibitor ( PAI ) 1 ) were assayed by ELISA with cells treated with 0 . 5 microM and 1 microM RAL for 48 h . u PA activity was evaluated by zymography and a direct fibrinolytic assay . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
MATERIAL AND METHODS : The incidence of the following factors was studied in 97 pregnant women with pregnancy complications and in 103 controls : R506Q mutation encoding Factor 5 Leiden [ FVL ] synthesis , Prothrombin G20210A mutation , T 677 methylenetetrahydropholate reductase mutation [ MTHFR ] , 4G / 4G polymorphism of the plasminogen activator inhibitor [ PAI 4G / 4G ] . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In vitro platelet aggregation induced by collagen and ADP , and variables of coagulation ( factor 7 amidolytic activity and concentrations of fibrinogen and prothrombin fragment 1 and 2 ) and fibrinolysis [ plasminogen activator inhibitor ( PAI ) activity and concentrations of tissue plasminogen activator ( tPA ) / PAI 1 complexes ] did not differ among the 3 diets . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In HUVECs , plasminogen activator inhibitor ( PAI ) 1 release was assayed by ELISA , while the PAI 1 and endothelin ( ET ) 1 mRNA levels were analyzed by Northern blotting . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
At baseline , on days 1 , 3 , 7 and 14 ( 7 days after thienopyridines discontinuation ) we measured ADP induced and spontaneous platelet aggregation ( PA ) , levels of prothrombin fragment 1+2 ( F1+2 ) , thrombin antithrombin complex ( TAT ) , von Willebrand factor ( vWF ) , fibrinogen , tissue type plasminogen activator antigen ( tPA ) , plasminogen activator inhibitor activity ( PAI ) and D dimer ( Dd ) , and counted platelet number . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
PURPOSE : Plasminogen activator inhibitor ( PAI ) 1 mediates transforming growth factor beta 1 ( TGF beta 1 ) related signaling by stimulating collagen Type 1 synthesis in radiation impaired wound healing . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This study was undertaken to investigate effects of TGFbeta 2 on secretion of fibronectin and the protease inhibitor plasminogen activator inhibitor ( PAI ) 1 from human TM cell cultures and perfused human ocular anterior segments . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUNd : Plasminogen activator inhibitor ( PAI ) 1 plays an important role in inflammation and tissue remodeling . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Thrombin antithrombin complex ( TAT ) was determined as a marker of thrombin generation , and plasminogen activator inhibitor ( PAI ) antigen was determined as a marker of fibrinolysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Low plasma levels of adiponectin ( hypoadiponectinemia ) and elevated circulating concentrations of plasminogen activator inhibitor ( PAI ) 1 are causally associated with obesity related insulin resistance and cardiovascular disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : The aim of this study was to investigate gingival crevicular fluid ( GCF ) levels of tissue plasminogen activator ( t PA ) and plasminogen activator inhibitor ( PAI 2 ) during orthodontic tooth movement in adults . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Blood samples were collected to analyse the levels of plasminogen activator inhibitor ( PAI ) 1 , cholesterol , triglyceride , low density lipoprotein , very low density lipoprotein , high density lipoprotein , apolipoprotein A 1 and apolipoprotein B . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The following coagulation tests were performed before and after maximal exercise : prothrombin time ( PT ) , partial activated thromboplastin time ( PTT ) , fibrinogen ( FBG ) , antithrombin 3 ( ATIII ) , protein C ( PC ) , protein S ( PS ) , prothrombin fragment 1+2 ( F1+2 ) , tissue activator of plasminogen ( t PA ) and its inhibitor ( PAI ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We examined the effect of overexpression of icIL 1ra on the phenotype and function of normal fibroblasts with respect to the expression of alpha smooth muscle actin ( alpha SMA ) , a specific marker for myofibroblasts , and plasminogen activator inhibitor ( PAI ) , a protein involved in fibrogenesis and expressed at higher levels in myofibroblasts , and the production of collagenase ( matrix metalloproteinase 1 ( MMP 1 ) ) , the major enzyme involved in the degradation of native collagen in the skin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Platelet cyclic guanosine monophosphate ( cGMP ) concentration ( as marker of NO production ) and serum levels of DHEA S , DHEA , IGF 1 , insulin , glucose , oestradiol ( E ( 2 ) ) , testosterone , plasminogen activator inhibitor ( PAI ) 1 antigen ( PAI 1 Ag ) , homocysteine and lipid profile were evaluated before and after the 2 month treatment with DHEA or placebo . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Overexpression of TGF beta 1 also stimulated expression of plasminogen activator inhibitor type 1 ( plasminogen activator inhibitor [ PAI ] 1 ) in the artery wall . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We measured insulin sensitivity ( euglycemic clamp ) , forearm blood flow responses to graded local acetylcholine ( Ach ) and sodium nitroprusside ( SNP ) infusions , plasma concentrations of tumor necrosis factor ( TNF ) alpha , interleukin ( IL ) 6 , von Willebrand factor ( vWF ) , plasminogen activator inhibitor ( PAI ) 1 , tissue plasminogen activator ( tPA ) , and high sensitivity C reactive protein ( hs CRP ) in 81 diabetic patients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The HUVECs were treated with various concentrations of BDNF ( 25 400 ng / ml ) for different ( 6 48 hours ) , reverse transcriptase polymerase chain reaction ( RT PCR ) was used to assay MMP 2 , MMP 9 , TIMP 1 , and TIMP 2 mRNA in HUVECs , and the conditioned medium was analyzed for MMP and uPA activity by gelatin zymography and fibrin zymography , respectively . uPA , plasminogen activator inhibitor ( PAI ) 1 , tissue inhibitors of metalloproteinase ( TIMP ) 1 , and TIMP 2 were quantified by western blotting analysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Expression of alphaB crystallin , fibronectin ( FN ) , plasminogen activator inhibitor ( PAI ) 1 , thrombospondin ( TSP ) 1 , and connective tissue growth factor ( CTGF ) mRNA and protein in medium perfused and TGF beta 2 perfused anterior segments was examined by Northern and Western blot analyses . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Clinical as well as experimental evidence suggests that vascular overexpression of plasminogen activator inhibitor ( PAI ) 1 , the primary physiological inhibitor of both urokinase and tissue type plasminogen activator , may be involved in the pathophysiology of atherosclerosis and cardiovascular disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The human protein CGI 55 has been described as a chromo helicase DNA binding domain protein ( CHD ) 3 interacting protein and was also found to interact with the 3 ' region of the plasminogen activator inhibitor ( PAI ) 1 mRNA . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue type plasminogen activator ( t PA ) , plasminogen activator inhibitor ( PAI ) , fibrinogen ( Fbg ) and D dimer ( DD ) were investigated after those rabbits had been treated . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Standard cardiovascular risk factors , including biomarkers of inflammation ( e . g . , high sensitivity C reactive protein [ hsCRP ] , interleukin [ IL ] 6 , and plasma fibrinogen ) and endothelial dysfunction ( e . g . , soluble intercellular adhesion molecule [ sICAM ] 1 [ , plasminogen activator inhibitor [ PAI ] 1 ) were assessed . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
MEKK 1 ablation or down regulation by interfering RNA significantly delays skin wound closure and impairs activation of Jun NH 2 terminal kinases , induction of plasminogen activator inhibitor ( PAI ) 1 , and restoration of cell cell junctions of the wounded epidermis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Instead , the protective effects of metformin correlated with complete prevention of the upregulation of plasminogen activator inhibitor ( PAI ) 1 caused by ethanol . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The plasminogen activator inhibitor ( PAI ) 1 , tissue plasminogen activator ( t PA ) and PAI I / t PA ratio were assessed before and after treatment . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A role for plasminogen activator inhibitor 1 in obesity : from pie to PAI . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : We sought to determine the etiologic mechanism of pleiotropic growth factor , hepatocyte growth factor ( HGF ) , as a regulator of hepatic synthesis of plasminogen activator inhibitor ( PAI ) 1 , the physiological inhibitor of fibrinolysis and a potential inducer of atherothrombosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The link between plasminogen activator inhibitor ( PAI ) 1 and the metabolic syndrome with obesity was established many years ago . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In this study , we investigated if total plasminogen activator inhibitor ( PAI ) activity , which is believed to increase in initial diagnosis and relapse in AML patients could be accepted as a relapse criterion or not . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To evaluate the role of plasminogen activators ( PAs ) in physiological angiogenesis , we have investigated the in vivo patterns of expression of urokinase type PA ( uPA ) and PA inhibitor type 1 ( PAI 1 ) during neovascularization of ovarian follicles , the corpus luteum , and the maternal decidua . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The levels of tissue type plasminogen activator ( t PA ) , type 1 plasminogen activator inhibitor ( PAI 1 ) , and t PA / PAI 1 complex antigens were analyzed in the plasma of disseminated intravascular coagulation ( DIC ) patients and healthy controls . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
At rest , heparin and Org 10172 did not influence the plasma concentrations of endogenous t PA antigen and activity , urokinase type PA ( u PA ) antigen , plasmin activatable pro urokinase ( scu PA ) , active urokinase ( tcu PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) antigen . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In HTII women , plasminogen activator inhibitor ( PAI 1 ) levels were higher and the euglobulin clot lysis time prolonged compared to NTII women . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The important role of thrombogenesis in CAD is supported by the fact that initial high levels of plasma fibrinogen , coagulation factor 7 ( VIIc ) , and plasminogen activator inhibitor ( PAI 1 ) are all independent risk factors for CAD or recurrent myocardial infarction as found in multivariate analyses of epidemiological studies . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
An increased blood fibrinolytic activity manifested by increased tissue plasminogen activator ( t PA ) and decreased tissue plasminogen activator inhibitor ( PAI 1 ) and increased FDP levels are seen in 40 patients with mild hypertrophy of prostate . ^^^ Surgical treatment increased blood fibrinolytic activity manifested in the increase in t PA , decrease in PAI 1 , shortening of ELT , increase in FDP , and decrease in plasminogen and 2 AP activities . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The effects of cyclic strain on the production of tissue plasminogen activator ( tPA ) and type 1 plasminogen activator inhibitor ( PAI 1 ) by cultured endothelial cells ( EC ) were examined . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor type 1 ( PAI 1 ) is a physiologic modulator of the fibrinolytic system . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The fibrinolytic response of type 4 patients was comparable to that of normolipidemic subjects , whereas tissue type plasminogen activator antigen levels before and after venous occlusion ( p less than 0 . 01 ) and resting plasminogen activator inhibitor 1 ( PAI 1 ) antigen ( p less than 0 . 01 ) and activity ( p less than 0 . 01 ) were significantly higher in hypertriglyceridemic subjects compared with controls . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The catabolism of t PA was not inhibited by an excess of urokinase type plasminogen activator ( u PA ) , and t PA bound to Novikoff membranes was not complexed to PAI 1 , suggesting a mechanism independent of PAI 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have shown that plasminogen activator inhibitor 1 ( PAI 1 ) inhibits the fibrin binding of both the single chain and two chain forms of tissue type plasminogen activator ( tPA ) through two different mechanisms . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Trophoblasts also secreted prourokinase and plasminogen activator inhibitors types 1 and 2 ( PAI 1 and PAI 2 ) . ^^^ Although prourokinase was secreted in amounts sufficient to endogenously saturate trophoblast uPA receptors , trophoblasts secreted greater amounts of PAI 1 and PAI 2 than uPA , and no net plasminogen activator activity was detected in trophoblast conditioned medium . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Previous studies with the human hepatoma cell line HepG 2 have identified a clearance system for t PA modulated by plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In order to determine the mechanism by which parathyroid hormone ( PTH ) stimulates plasminogen activator ( PA ) activity in rat osteoblasts , we investigated the effect of human PTH ( 1 34 ) [ hPTH ( 1 34 ) ] on the synthesis of mRNAs for tissue type PA ( tPA ) , urokinase type PA ( uPA ) , and PA inhibitor 1 ( PAI 1 ) , and on release of PA activity and PAI 1 protein in both normal rat calvarial osteoblasts and UMR 106 01 osteogenic sarcoma cells . hPTH ( 1 34 ) ( 0 . 25 25 nM ) decreased PAI 1 mRNA and protein , and increased PA activity in both cell types in a dose dependent manner with ED 50 of about 1 nM for both responses . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We examined the regulation and cellular localization of plasminogen activator inhibitor type 1 ( PAI 1 ) and tissue inhibitor of metalloproteinase type 1 ( TIMP 1 ) mRNAs by in situ hybridization . [ 35S ] UTP labeled RNA probes were hybridized to ovarian sections of eCG primed immature rats treated with hCG . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Expression of proteins which modulate the degradative potential of these enzymes , plasminogen activator inhibitors 1 and 2 ( PAI 1 , PAI 2 ) , uPA receptor , and tissue inhibitors of metalloproteases 1 and 2 ( TIMP 1 and TIMP 2 ) , were also assayed . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
When urokinase plasminogen activator / urokinase plasminogen activator receptor complex binds plasminogen activator inhibitor ( PAI 1 ) , the inhibitor triggers a series of events leading to internalization of the entire complex . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In this study , we report the effects of recombinant human TNF alpha on the synthesis of tissue type plasminogen activator ( t PA ) and its inhibitor ( PAI 1 ) by human mesangial cells in culture . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The parameters studied are cellular procoagulant activity , secretion of plasminogen activator inhibitor ( PAI 1 ) and urokinase type plasminogen activator ( u PA ) , activation and internalization of factor 10 and Merocyanine 540 staining . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Treatment with an excess of antibodies against plasminogen activator inhibitor type 1 ( PAI 1 ) caused an 80 % decrease in the binding , leaving about 1 . 6 10 10 ( 5 ) unoccupied binding sites per cell , which appeared to be different from PAI 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have investigated the mechanisms by which type 1 plasminogen activator inhibitor ( PAI 1 ) is regulated by transforming growth factor beta ( TGF beta ) and by epidermal growth factor ( EGF ) in CCL 64 mink lung epithelial cells , BSC 1 monkey kidney epithelial cells , mouse embryo fibroblast ( AKR 2B 84A ) cells and normal rat kidney fibroblasts ( NRK ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Receptor mediated endocytosis of tissue type plasminogen activator ( t PA ) plasminogen activator inhibitor type 1 ( PAI 1 ) complexes results in their clearance by Hep G 2 cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The sequence of two clones from a cDNA library of EGF induced cells and the amino terminal sequence of the purified protein revealed that EIP 1 is identical to rat plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Two plasminogen activators ( PAs ) : tissue type plasminogen activator ( t PA ) and urokinase type plasminogen activator ( u PA ) , as well as the type 1 plasminogen activator inhibitor ( PAI 1 ) are synthesized and secreted by rat astrocytes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Raised plasma levels of fibrinogen , factor VIIc , and plasminogen activator inhibitor 1 ( PAI 1 ) are associated with an increased risk of ischemic heart disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Two recent findings , however , strongly suggest a contribution : ( 1 ) Increased lipoprotein ( a ) levels that reduce tissue type plasminogen activator ( t PA ) mediated clot lysis are a clear risk factor for atherosclerosis ; and ( 2 ) increased plasminogen activator inhibitor 1 ( PAI 1 ) levels in patients with disturbed glucose tolerance predispose to an accelerated development of atherosclerotic disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Confluent monolayers were stimulated by human recombinant interleukin ( IL 1 beta ) and responses in terms of tissue factors like procoagulant activity , tissue plasminogen activator ( tPA ) and plasminogen activator inhibitor ( PAI 1 ) were followed for up to 72 h . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Expression of plasminogen activator and plasminogen activator inhibitor mRNA in human fibroblasts grown on different substrates . mRNA levels for urokinase type plasminogen activator ( uPA ) , tissue type plasminogen activator ( tPA ) , plasminogen activator inhibitor 1 ( PAI 1 ) and plasminogen activator inhibitor 2 ( PAI 2 ) were examined in human diploid ( neonatal foreskin ) fibroblasts grown in 200 ml microcarrier suspension culture . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Vitronectin ( complement S protein , serum spreading factor , epibolin ) is a multifunctional glycoprotein that mediates cell to substrate adhesion , inhibits the cytolytic action of the terminal complement cascade in vitro and binds to several serine protease inhibitors of the serpin family , viz . antithrombin 3 , plasminogen activator inhibitor 1 ( PAI 1 ) and 2 ( PAI 2 ) , heparin cofactor 2 and protease nexin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) , the major physiologic inhibitor of tissue plasminogen activator ( tPA ) , plays a crucial role in the regulation of fibrinolysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In contrast , fluid phase type 1 plasminogen activator inhibitor ( PAI 1 , 5 15 units / ml ) does not inhibit invasiveness unless preincubated with the amnion membranes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) , a member of the serpin superfamily of proteins , has been demonstrated previously to interact functionally with the glycosaminoglycan heparin ( Ehrlich , H . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Vitronectin ( VN ) has been implicated as a major matrix associated regulator component of plasminogen activation by serving as a potent stabilizing cofactor of plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^ The direct binding of heparin , plasminogen as well as PAI 1 in its latent and active form to immobilized VN was studied in the absence or presence of competitors . ^^^ Monoclonal antibodies against the carboxyl terminal portion of VN inhibited both PAI 1 and plasminogen binding , whereas heparin , heparan sulfate with a high degree of sulfation , or dextran sulfate interfered with PAI 1 binding ( KD = 20 nM ) only . ^^^ Binding of Lys plasminogen and active site blocked plasmin was at least 10 fold higher in affinity ( KD = 85 100 nM ) compared to Glu plasminogen ( KD approximately 1 microM ) and could be inhibited by lysine analogs but not by glycosaminoglycans or PAI 1 , indicating that heteropolar plasmin ( ogen ) binding of VN occurs to an adjacent segment upstream to the heparin and PAI 1 binding sites . ^^^ This contention was further supported in binding studies with plasmin modified VN which lost both heparin and PAI 1 binding but exhibited 2 3 fold higher capacity to bind plasminogen . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Complexes of urokinase and plasminogen activator inhibitor type 1 ( PAI 1 ) were detected in cell layers of vitronectin adherent but not fibronectin adherent cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Complexes between 125I labeled urokinase type plasminogen activator ( uPA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) bound to purified alpha 2 macroglobulin ( alpha 2M ) receptor ( alpha 2MR ) / low density lipoprotein receptor related protein ( LRP ) . ^^^ PAI 1 was blocked by natural and recombinant alpha 2MRAP , and about 80 % inhibited by complexes between tissue type plasminogen activator ( tPA ) and PAI 1 , and by a monoclonal anti PAI 1 antibody . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Over a similar time course , both mRNA and protein levels of type 1 plasminogen activator inhibitor ( PAI 1 ) were enhanced by SPARC and the SPARC 4 23 peptide . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Retinoic acid induces tissue type plasminogen activator ( t PA ) but not plasminogen activator inhibitor 1 ( PAI 1 ) expression in cultured human umbilical vein endothelial cells ( HUVEC ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To further address this issue , we evaluated the ability of TNF to regulate : 1 ) PA and plasminogen activator inhibitor ( PAI 1 ) mRNA expression and 2 ) endothelial cell surface associated PA and PAI 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) , the principal physiological inhibitor of tissue plasminogen activator ( tPA ) , is a protein of 379 amino acids and belongs to the SERPIN family of serine protease inhibitors . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Progesterone regulation of plasminogen activator inhibitor 1 ( PAI 1 ) antigen and mRNA levels in human endometrial stromal cells . ^^^ Plasminogen activator inhibitor type 1 ( PAI 1 ) is an efficient inhibitor of both tissue type and urokinase type plasminogen activators , and may therefore be instrumental for the control of plasminogen activation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In order to clarify the effect of hemodialysis ( HD ) on the fibrinolytic system , fibrinolytic activity was evaluated in 27 patients undergoing regular hemodialysis treatment ( RDT ) using new parameters including plasma alpha 2 plasmin inhibitor ( alpha 2 PI ) , alpha 2 plasmin inhibitor plasmin complex ( alpha 2 PIC ) , cross linked fibrin degradation products ( XL FDP ) , tissue plasminogen activator ( t PA ) activity , t PA antigen and plasminogen activator inhibitor 1 ( PAI 1 ) antigen . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Postoperative fibrinolytic shutdown has been attributed to an increase in plasma levels of type 1 plasminogen activator inhibitor ( PAI 1 ) activity and may contribute to postoperative venous thrombosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Immunological and functional levels of tissue type plasminogen activator ( t PA ) and type 1 plasminogen activator inhibitor ( PAI 1 ) were quantified in platelet poor plasma ( PPP ) from patients with CTEPH as well as age matched controls . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma levels of plasminogen activators ( t PA , u PA ) and their inhibitor ( PAI 1 ) were studied in patients suffering from Buerger ' s disease and healthy volunteers before and after 15 minutes of venous occlusion test . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is a rapid inhibitor of tissue plasminogen ( tPA ) in vivo . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) levels increased from 59 + / 35 micrograms / l to 113 + / 39 micrograms / l at 6 h ( P < 0 . 01 ) . tPA PAI 1 complexes increased from 0 . 15 + / 0 . 07 to 0 . 69 + / 0 . 21 nmol / l at 6 h ( P < 0 . 01 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma levels of tissue plasminogen activator ( t PA ) antigen , plasminogen activator inhibitor 1 ( PAI 1 ) antigen and t PA / PAI 1 complex were measured in plasmas from 18 healthy subjects and 75 patients with various diseases ( 28 patients with haematological malignancies , 20 with thrombotic diseases , five with infectious diseases , four with liver diseases , ten with bleeding disorders and eight miscellaneous conditions ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To determine the relation of post percutaneous transluminal coronary angioplasty ( PTCA ) restenosis to serum lipid fractions and to circulating levels of endogenous tissue plasminogen activator ( t PA ) and its rapid inhibitor ( PAI 1 ) , 68 patients with coronary artery disease who underwent a successful PTCA were studied . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Recombinant plasminogen activator inhibitor type 1 ( PAI 1 ) purified in an active form from Escherichia coli and eucaryotic cells was found to contain a mixture of three functionally distinct forms : an active form that forms complexes with plasminogen activators ( PAs ) , an inactive ( latent ) form that remains intact after incubation with PAs , and a substrate like form which is easily cleaved by PAs . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma concentration of thrombin antithrombin 3 complex ( TAT ) , tissue type plasminogen activator ( t PA ) , plasminogen activator inhibitor 1 ( PAI 1 ) , PAI 2 , D dimer complex and urokinase plasminogen activator ( u PA ) activity were studied in 30 patients with acute nonlymphoblastic leukemia ( ANLL ) , before and during antileukemic therapy . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In 29 lean , premenopausal , never treated hypertensive women ( 142 + / 2 / 93 + / 1 mmHg , mean + / SEM ) plasminogen activator inhibitor ( PAI 1 ) was elevated ( 11 . 0 + / 1 . 5 U / ml vs 6 . 3 + / 1 . 0 U / ml , p less than 0 . 05 ) compared to healthy , normotensive women ( 113 + / 2 / 71 + / 2 mmHg ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the present prospective follow up study the effect of 16 weeks insulin treatment and glycemic regulation on plasma levels of tissue plasminogen activator ( tPA ) and plasminogen activator inhibitor 1 ( PAI 1 ) , the main regulators of fibrinolysis , was investigated in 19 type 2 diabetic patients with secondary failure to sulphonylureas . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Weight loss was accompanied at 12 months by significant reductions in median ( interquartile range ) concentrations of serum cholesterol from 5 . 3 ( 4 . 5 6 . 2 ) mmol / l to 3 . 6 ( 2 . 9 4 . 6 ) mmol / l ; factor 7 from 113 ( 92 145 ) % of normal to 99 ( 85 107 ) % ; of fibrinogen from 3 . 5 ( 3 9 . 3 ) g / l to 2 . 8 ( 2 . 4 3 . 8 ) g / l ; and of plasminogen activator inhibitor 1 ( PAI 1 ) activity from 21 ( 11 30 ) IU / ml to 6 . 3 ( 5 10 ) IU / ml . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Type 1 plasminogen activator inhibitor ( PAI 1 ) , the primary physiological inhibitor of endogenous plasminogen activators , modulates fibrinolysis , cell migration , and tissue repair . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have shown previously that products from activated platelets can augment synthesis of plasminogen activator inhibitor type 1 ( PAI 1 ) in cultured endothelial and hepatoma ( Hep G 2 ) cells in vitro and increase plasma PAI 1 activity in vivo in rabbits . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Rat ovarian cells produce not only plasminogen activator ( tPA ) but also plasminogen activator inhibitor type 1 ( PAI 1 ) , and their coordinated geneexpression induced by gonadotropins are thought to be responsible for follicular rupture . ^^^ In this study , it was demonstrated that ( 1 ) theca interstitial compartment synthesizes the majority of PAI 1 activity in the ovary before ovulation , the follicular wall may therefore serve as a specific barrier to prevent the secretion of PA into the extrafollicular compartment ; ( 2 ) Granulosa cells contribute only small amount of ovarian PAI 1 activity , but synthesize most of tissue type plasminogen activator activity involved in the process leading to ovulation : ( 3 ) Since only matured cumulus oocyte complexes secrete high level of tPA and PAI 1 , both tPA and PAI 1 activity in the conditioned medium may be used as reliable markers for evaluating oocyte quality for in vitro fertilization . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A new assay for functional plasminogen activator inhibitor 1 ( PAI 1 ) in plasma was developed . ^^^ The assay is based on the quantitative conversion of PAI 1 to urokinase type plasminogen activator ( u PA ) PAI 1 complex the concentration of which is then determined by an ELISA employing monoclonal anti PAI 1 as catching antibody and monoclonal anti u PA as detecting antibody . ^^^ The level of functional PAI 1 , tissue type plasminogen activator ( t PA ) activity and t PA PAI 1 complex was measured in normal subjects and in patients with venous thromboembolism in a silent phase . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Before occlusion plasma levels of tissue type plasminogen activator ( t PA ) antigen and its inhibitor ( PAI 1 ) were significantly higher in the patient group ( p < 0 . 001 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In healthy female volunteers ( aged 20 46 years , 18 smokers and 17 non smokers ) platelet life span and indices of platelet activity were determined , together with plasma levels of plasminogen activator inhibitor 1 ( PAI 1 ) , fibrinogen , peripheral blood cell counts and hematocrit . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The mean plasminogen inhibitor 1 ( PAI 1 ) activity of the patients was elevated compared with healthy controls . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
It was found that an M ( r ) 72 , 000 protein was digested to an M ( r ) 62 , 000 form by human mast cell tryptase while the plasminogen activator inhibitor , PAI 1 , was not affected . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
These mononucleated , round shaped , migrating cells are HLA A , B , C class 1 antigen ( W6 / 32 ) antibody and low molecular weight cytokeratin positive , and do not immunostain with PAI 1 ( plasminogen activator inhibitor ) and HPL antibodies . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have shown that the urokinase ( UK ) kringle domain contains a high affinity plasminogen activator inhibitor 1 ( PAI 1 ) binding site , responsible for the 10 fold faster complex formation between UK and PAI 1 than between PAI 1 and low molecular weight urokinase ( LMWUK ) . ^^^ Inactivation of tissue type plasminogen activator ( tPA ) by PAI 1 was slowed 10 fold in the presence of peptides derived from the tPA finger and kringle 2 domains . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor type 1 ( PAI 1 ) was significantly raised in remission ( median 11 , range 3 32 ng / ml ) when compared to active disease ( median 7 , range 3 42 ng / ml ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Angiotensin 2 ( AII ) stimulates plasminogen activator inhibitor 1 ( PAI 1 ) gene transcription , translation , and protein secretion from astroglial cells derived from normotensive [ Wistar Kyoto ( WKY ) ] rat brain , an effect mediated by AII type 1 ( AT 1 ) receptors . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Type 1 plasminogen activator inhibitor ( PAI 1 ) is the primary inhibitor of tissue type plasminogen activator and has been found to be increased in a number of clinical conditions generally defined as prothrombotic . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have previously reported that incubation of human umbilical vein endothelial cells ( HUVECs ) with human alpha thrombin causes a time and concentration dependent increase in secreted plasminogen activator inhibitor type 1 ( PAI 1 ) activity ( Gelehrter TD , Sznycer Laszuk R . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor type 1 ( PAI 1 ) in plasma was measured with an assay employing a specific monoclonal antibody in 40 consecutive children hospitalized with the hemolytic uremic syndrome : 12 who recovered adequate renal function ( serum creatinine , less than or equal to 2 . 0 mg per deciliter [ 177 mumol per liter ] ) without dialysis , 23 who recovered adequate renal function after peritoneal dialysis , and 5 who did not recover adequate renal function after undergoing dialysis . ^^^ That the inhibitor was PAI 1 was indicated by the fact that it was a potent inhibitor of tissue plasminogen activator , was acid resistant , and was not inhibited by denaturation ( all unique traits of PAI 1 ) and that it was neutralized by an antibody specific for PAI 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Using chemical crosslinking , we have recently identified a plasminogen activator inhibitor type 1 ( PAI 1 ) independent t PA clearance receptor on rat hepatoma MH1C1 cells with a relative molecular mass of approximately 500 kDa . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In vitro , inflammatory mediators , such as TNF , favor glomerular thrombogenic properties through enhancement of thromboplastin synthesis and of plasminogen activator inhibitor PAI 1 , and through decrease in thrombomodulin activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) accumulates within thrombi and forming whole blood clots . ^^^ The experiments were performed by adding 125I PAI 1 , which retains its complete tissue type plasminogen ( t PA ) inhibitory activity , to fibrin matrices formed in 2 cm 2 tissue culture wells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
By Northern analysis , we now demonstrate that plasminogen activator inhibitor 1 ( PAI 1 ) mRNA is increased in multiple wounded monolayers of bovine microvascular ( BME ) or aortic ( BAE ) endothelial cells , with a maximal 7 and 9 fold increase 4 h after wounding , respectively . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The plasma levels of tissue type plasminogen activator ( t PA ) , plasminogen activator inhibitor 1 ( PAI 1 ) , and the t PA / PAI 1 complex ( including various coagulation factors ) were assayed in 72 patients with coronary artery disease ( CAD ) and 29 control ( C ) subjects . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To elucidate the circadian variation of fibrinolytic components in vasospastic angina , plasma levels of tissue plasminogen activator antigen ( t PA ) , free plasminogen activator inhibitor antigen ( free PAI 1 ) , t PA / PAI 1 complex , and total PAI 1 were measured in venous plasma samples . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Whilst increased plasma beta thromboglobulin ( beta TG ) , platelet factor 4 and thrombospondin levels are regarded as reflecting the release reaction of platelets , tissue type plasminogen activator ( t PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) levels represent endothelial release reaction and / or damage . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In this study , we investigated the mechanism of angiotensin 2 ( Ang 2 ) induced secretion of plasminogen activator inhibitor 1 ( PAI 1 ) from astroglial cells prepared from 21 day old rat brain . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have previously shown that alpha thrombin exerted a mitogenic effect on human glomerular epithelial cells and stimulated the synthesis of urokinase type ( u PA ) and tissue type plasminogen activator ( t PA ) and of their inhibitor , plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
P uPA had a low affinity for the inhibitors of plasminogen activator PAI 1 and PAI 2 , and was inhibited only by the excess amounts of inhibitors . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Co secretion of plasminogen activator inhibitor type 1 ( PAI 1 ) and urokinase type plasminogen activator was identified in short term cultures of primary type 2 pneumocytes isolated from adult rats . ^^^ Type 2 pneumocyte PAI 1 formed SDS resistant complexes with tissue type and urokinase type plasminogen activator and was found to be stable to acid , to short term exposure to heat , and to the denaturants guanidine HCl and SDS , while being sensitive to treatment with alkali and urea . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This difference was not due to the release of plasminogen activator inhibitor 1 ( PAI 1 ) by platelets . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Human mesangial cells in culture synthesize and secrete plasminogen activator inhibitor 1 ( PAI 1 ) and tissue type plasminogen activator ( t PA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is a specific inhibitor of the serine proteases tissue type plasminogen activator ( tPA ) and urokinase type plasminogen activator ( uPA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To evaluate whether baseline levels of endogenous tissue type plasminogen activator ( t PA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) predict the future occurrence of venous thrombosis , levels of these proteins were measured in prospectively collected plasma samples from 55 participants in the Physicians ' Health Study who later developed deep venous thrombosis or pulmonary embolism and from an equal number of age and smoking matched control subjects who remained free of vascular disease during a mean follow up period of 60 . 2 months . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
For these studies we used the firefly luciferase gene under control of several different promoters including those for the Rous sarcoma virus ( RSV ) and for tissue plasminogen activator type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This study was aimed to clarify the influence of aging and circadian fluctuation of fibrinolytic factors to changes of tissue plasminogen ( t PA ) and its inhibitor ( PAI 1 ) during venous occlusion test . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Most patients with thrombotic disease have a defective fibrinolytic defense system caused either by plasminogen activator deficiency , excess of plasminogen activator inhibitor ( PAI 1 ) , or a combination of the two . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma epinephrine , active and total t PA , active plasminogen activator inhibitor type 1 ( PAI 1 ) and t PA / PAI 1 complex concentrations were measured at each exercise and infusion level . ^^^ In these healthy subjects , active plasminogen activator inhibitor type 1 and t PA / PAI 1 complex levels were low ( 41 + / 11 and 21 + / 5 pmol / liter , respectively ) and did not change significantly during exercise or epinephrine infusion . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) , the primary physiological inhibitor of tissue type plasminogen activator ( t PA ) in plasma , is a serine proteinase inhibitor ( serpin ) that forms a 1 : 1 stoichiometric complex with its target proteinase leading to the formation of a stable inactive complex . ^^^ Other serine proteinases , e . g . urokinase type plasminogen activator and thrombin , also cleaved this `` substrate ' ' form of PAI 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is a serine protease inhibitor that inhibits both tissue type and urokinase type plasminogen activators . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Similarly the initial elevation in plasminogen activator inhibitor 1 endothelial type ( PAI 1 ) levels remained high until days 4 and 7 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Because increased concentrations of plasminogen activator inhibitor type 1 ( PAI 1 ) occur also , we hypothesized that proinsulin and split proinsulin may augment endothelial cell PAI 1 expression , thereby potentially attenuating endogenous fibrinolysis and accelerating atherosclerosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) antigen was measured in a phosphate buffered saline ( PBS ) extract of each thrombus ; t PA antigen and plasminogen antigen were determined in a 6 M urea extract of the thrombus , representing bound proteins . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The effect of fibrin on the interaction of human recombinant single chain tissue plasminogen activator ( t PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) was studied in normal rabbit plasma and in plasma with high levels of native PAI 1 . t PA was added to diluted plasma containing calcium ( 10 mM ) and 125I fibrinogen at 37 degrees C . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In cross sectional studies a positive correlation has been found between circulating insulin , triglycerides and plasminogen activator inhibitor ( PAI 1 ) activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Daytime fluctuations of plasminogen activator inhibitor 1 ( PAI 1 ) in populations with high PAI 1 levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The plasma activity of plasminogen activator inhibitor 1 ( PAI 1 ) was measured in 278 clinically healthy subjects ( 98 men , 180 women ; mean age 26 [ 18 50 ] years ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In humans and non human primates , alternative cleavage and polyadenylation of plasminogen activator inhibitor type 1 ( PAI 1 ) pre mRNA transcripts results in two forms of mature mRNA , an unstable 3 . 2 kilobase ( kb ) form , and a relatively more stable 2 . 2 kb form . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To determine a possible relation of changes in plasma levels of plasminogen activator inhibitor 1 ( PAI 1 ) and tissue plasminogen activator ( t PA ) to the development of coronary restenosis after successful coronary angioplasty ( PTCA ) , we followed 104 patients with a low grade residual stenosis after PTCA ( less than 30 % ) for a period of 12 months . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue type plasminogen activator ( t PA ) induces synthesis of a rapidly acting inhibitor , plasminogen activator inhibitor type 1 ( PAI 1 ) in human umbilical vein endothelial cells ( HUVEC ) in culture . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The release of plasminogen activators ( t PA and u PA ) and plasminogen activator inhibitor ( PAI 1 ) after venous stasis . ^^^ The aim of the present study was to compare plasma levels of urokinase type plasminogen activator ( u PA ) , before and after 20 min of venous stasis , with those of tissue type plasminogen activator ( t PA ) , type 1 plasminogen activator inhibitor ( PAI 1 ) and t PA / PAI 1 complexes , to determine whether both plasminogen activators and their inhibitor respond similarly to the same stimulus . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In a subset of 20 patients with physical training , resting levels of plasmin alpha 2PI complex ( PIC ) , thrombin antithrombin 3 complex ( TAT ) , protein C ( P C : Ag ) , plasminogen activator inhibitor 1 ( PAI 1 ) , 7 : C , and P C activities had significantly decreased after one month of physical training ( p less than 0 . 05 ) , although tissue plasminogen activator activities remained unchanged . ^^^ The decrease in plasminogen , t PA : Ag , alpha 2PI , PAI 1 , and PIC after physical training may result from the decreased coagulability . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Therefore , we measured markers of free radical activity ( nonperoxide conjugated diene isomer of linoleic acid [ PL 9 , 11 LA ' ] and lipid peroxides expressed as malondialdehyde [ MDA ] ) along with the hemostatic variables : fibrinogen , von Willebrand factor ( vWf ) , plasminogen activator inhibitor ( PAI 1 ) , tissue plasminogen activator ( t PA ) , and plasmin activity ( B beta 15 42 ) in 24 NIDDM patients ( 12 patients with microalbuminuria and 12 without microalbuminuria ) and in 12 age matched control subjects . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The plasminogen activator activity of the culture medium was analyzed using caseinolysis in agar and zymography assays , immunoblotting , and Northern hybridization analysis for the plasminogen activators ( PA ) and PA inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The patients had a lower mean fibrinolytic response to venous occlusion than the controls and higher antigen levels of tissue type plasminogen activator ( t PA : Ag ) and plasminogen activator inhibitor type 1 ( PAI 1 : Ag ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Human mesangial cells secrete tissue type plasminogen activator ( t PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) , the latter being secreted in large excess in vitro . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Phorbol 12 myristate 13 acetate induces a 3 and 10 fold induction of chloramphenicol acetyltransferase ( CAT ) activity in HT 1080 and HeLa cells , respectively , following transient transfection of a 336 base pair plasminogen activator inhibitor 1 ( PAI 1 ) promoter fragment linked to a CAT reporter gene . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The concentrations of urinary type plasminogen activator ( u PA ) , plasminogen activator inhibitor 1 ( PAI 1 ) , and PAI 2 were measured in gastric cancer tissues and adjacent healthy mucosal tissues . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Expression of plasminogen activator inhibitor type 1 ( PAI 1 ) , an important determinant of the pericellular proteolytic environment , was assessed in cultured human orbital and dermal fibroblasts . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have examined the effect of cytoskeleton disrupting agents on the production and secretion of another proteolytic enzyme , tissue plasminogen activator ( tPA ) , and its inhibitor , plasminogen activator inhibitor 1 ( PAI 1 ) , in human endothelial cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To determine the relationship between cardiovascular complications of estrogen therapy and fibrinolysis , fibrinolysis parameters plasminogen , urokinase type plasminogen activator ( u PA ) , tissue type plasminogen activator ( t PA ) , and plasminogen activator inhibitor 1 ( PAI 1 ) , were assessed in 12 prostatic cancer patients before and 6 weeks after the onset of estrogen therapy . ^^^ The levels of plasminogen , u PA , and PAI 1 in the patients treated with the estrogen therapy were significantly higher than those in the patients before the therapy . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The coding sequences for echistatin ( Echis ) and human plasminogen activator inhibitor type 1 ( PAI 1 ) were inserted in frame with the MEL1sp . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Using endothelial cells from human umbilical vein ( HUVECs ) and human aorta ( HAECs ) , we have studied this regulation of t PA and its inhibitor , plasminogen activator inhibitor 1 ( PAI 1 ) , at the mRNA level and have compared their induction with the expression of platelet derived growth factors A and B ( PDGF A and PDGF B ) and the proto oncogenes c jun and c fos . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is the principal inhibitor of the two activators of the fibrinolytic system : tissue and urokinase type PAs ( t PA and u PA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The second messengers and protein kinases involved in the induction of type 1 plasminogen activator inhibitor ( PAI 1 ) synthesis by various agents were evaluated in cultured bovine aortic endothelial cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In man , the plasminogen activator inhibitor 1 ( PAI 1 ) gene codes for two mRNA species , one of 3 . 2 kilobases ( kb ) and the other of 2 . 4 kb . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
These include cellular release of tissue plasminogen activator , activated protein C induced fibrinolysis , and inactivation of plasminogen activator inhibitor , type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In contrast , EGF specifically enhanced the expression of plasminogen activator inhibitor 1 ( PAI 1 ) and tissue inhibitor of metalloproteinases 1 ( TIMP 1 ) in IMC 2 cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Zymographic analysis of secreted PA related compounds revealed production of free urokinase ( u PA ) and type 1 plasminogen activator inhibitor ( PAI 1 ) complexed to tissular plasminogen activator ( t PA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Constitutive plasminogen activator inhibitor 1 ( PAI 1 ) biosynthesis in human Hep G 2 hepatoma cells is maintained by an autocrine factor . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor type 1 ( PAI 1 ) is a physiologic modulator of the fibrinolytic system . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) , a rapid inhibitor of tissue type plasminogen activator , has been shown to be an independent risk factor for recurrent myocardial infarction ( MI ) at a young age . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Complexing of tissue plasminogen activator with PAI 1 , alpha 2 macroglobulin , and C 1 inhibitor : studies in patients with defibrination and a fibrinolytic state after electroshock or complicated labor . ^^^ Complexes of t PA with plasminogen activator inhibitor 1 ( PAI 1 ) , alpha 2 macroglobulin and C 1 inhibitor were also observed . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The VN multimers catalyzed by TG retained functional activity in binding [ 3H ] heparin , platelets , and plasminogen activator inhibitor type 1 ( PAI 1 ) . [ 3H ] Heparin bound selectively to the 65 kDa monomeric band of VN and to the multimers derived from this band . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Explants from a glioblastoma multiforme were maintained for 4 weeks in a three dimensional Gelfoam matrix culture in order to study the synthesis of alpha 2 antiplasmin ( alpha 2AP ) , alpha 2 macroglobulin ( alpha 2M ) , plasminogen activator inhibitor 1 ( PAI 1 ) , and tissue plasminogen activator ( t PA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Surprisingly , we find that these agents also induce plasminogen activator inhibitor 1 ( PAI 1 ) activity and mRNA in BME cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The generation of TGF beta in co cultures stimulated the production of the protease inhibitor plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Bovine aortic endothelial cells ( BAEs ) were used as a model system to study the nature and origin of protein ( s ) in the extracellular matrix that bind to type 1 plasminogen activator inhibitor ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The interaction of plasminogen activator inhibitor 1 ( PAI 1 ) with its binding protein vitronectin ( VN ) ( Declerck , P . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Polyclonal antibodies against plasminogen activator inhibitor type 1 ( PAI 1 ) caused rapid retraction and rounding of substrate attached HT 1080 cells . ^^^ In the presence of a neutralizing antibody against PAI 1 , vitronectin adherent cells activated plasminogen to the same extent as fibronectin adherent cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Three chimeric mutants of plasminogen activator inhibitor 1 ( PAI 1 ) have been constructed where the strained loop of wild type PAI 1 ( wtPAI 1 ) has been replaced with a 19 amino acid region from either plasminogen activator inhibitor 2 ( PAI 2 ) , antithrombin 3 , or with an artificial serine protease inhibitor superfamily consensus strained loop . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) inhibits the tissue plasminogen activator ( tPA ) and urokinase activation of plasminogen to plasmin , a protease of trypsin like specificity which is involved in a number of processes , including fibrinolysis , matrix degradation and angiogenesis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Functional interaction of plasminogen activator inhibitor type 1 ( PAI 1 ) and heparin . ^^^ Plasminogen activator inhibitor type 1 ( PAI 1 ) , the fast acting inhibitor of tissue type plasminogen activator ( t PA ) and urokinase ( u PA ) , is a member of the serpin superfamily of proteins . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
By enzyme linked immunosorbent assays , forskolin was found to cause a 2 to 4 fold decrease in intracellular and culture medium levels of type 1 inhibitor of plasminogen activators ( PAI 1 ) and tissue type plasminogen activator ( t PA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The interaction between type 1 plasminogen activator inhibitor ( PAI 1 ) and fragments of vitronectin ( Vn ) was investigated . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Catabolism of plasminogen activators by Hep G 2 cells is mediated by a specific receptor which recognizes complexes of these serine proteases with their physiological inhibitor , plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^ This catabolic process is initiated by interaction of exogenous plasminogen activators with bioactive PAI 1 , which is secreted and localizes in an active form to the extracellular matrix ( ECM ) of Hep G 2 cells . ^^^ VN associated with the ECM may confer retention and bioactivity to PAI 1 , potentially facilitating both pericellular regulation of plasmin generation and the rapid hepatic clearance of plasminogen activators . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Hybridization of poly ( A ) + RNA northern blots revealed only the cytoskeletal beta actin message ; by using the more sensitive solution hybridization assay , the plasminogen activator inhibitor 1 ( PAI 1 ) and von Willebrand factor ( vWF ) mRNAs were quantified . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Increased plasminogen activator inhibitor 1 ( PAI 1 ) antigen levels in plasma from patients with septicemia decreased the ratio of the plasma clot lysis rate induced by an anti alpha 2 plasmin inhibitor monoclonal antibody to the tissue type plasminogen activator ( t PA ) concentration . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) regulates fibrinolysis by inhibiting tissue type plasminogen activator ( t PA ) . ^^^ In addition , these experiments indicate that Lp ( a ) may regulate fibrinolysis by competing with PAI 1 and plasminogen for fibrinogen and heparin bound t PA . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The `` serpin ' ' plasminogen activator inhibitor 1 ( PAI 1 ) is the fast acting inhibitor of plasminogen activators ( tissue type ( t PA ) and urokinase type PA ) and is an essential regulatory protein of the fibrinolytic system . ^^^ Nevertheless , by using PAI 1 reactive site variants ( R346M , M347S , and R346M M347S ) , we show that the binding of vitronectin to the PAI 1 mutant proteins improves plasminogen activator inhibition . ^^^ In addition , we show that the inhibition of t PA and urokinase type PA by PAI 1 mutant proteins is accelerated by the presence of the nonprotease A chains of the plasminogen activators . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The interaction between guanidine activated bovine type 1 plasminogen activator inhibitor ( PAI 1 ) and bovine vitronectin was investigated . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The acute phase behaviour of the fast inhibitor of tissue type plasminogen activator ( PAI 1 ) in vivo has been attributed to increased synthesis by endothelial cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) , an essential regulatory protein of the fibrinolytic system , harbors interaction sites for plasminogen activators ( tissue type [ t PA ] and urokinase type [ u PA ] ) and for fibrin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the current work we have analyzed the regulation of vitronectin by transforming growth factor beta 1 ( TGF beta 1 ) in this hepatoma cell line by Northern hybridization , polypeptide and immunoprecipitation analyses and compared the response to another TGF beta regulated gene , plasminogen activator inhibitor ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This protein was identified as type 1 plasminogen activator inhibitor ( PAI 1 ) on Western blots with anti PAI 1 antiserum . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
As a result of the plasmin cleavage , the affinity between vitronectin and the type 1 inhibitor of plasminogen activator ( PAI 1 ) is significantly reduced . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In human umbilical vein endothelial cells high glucose increased fibronectin , collagen 4 , tissue plasminogen activator ( tPA ) , and plasminogen activator inhibitor 1 ( PAI 1 ) mRNA levels 2 fold but did not affect type 4 and interstitial collagenase expression . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Another antibody , TPA 2 14 , partially inhibited the enzymatic activities of tPA towards the synthetic substrate and plasminogen , but it was not able to bind to the inactive tPA complexed with plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is the fast acting inhibitor of both tissue type and urokinase type plasminogen activators ( t PA , u PA ) and is an essential regulatory protein of the fibrinolytic system . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
However , it did not significantly modulate urokinase type plasminogen activator ( u PA ) , tissue type plasminogen activator ( t PA ) , plasminogen activator inhibitor ( PAI 1 ) , and tissue factor ( TF ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Accelerated atherosclerosis accompanying diabetes mellitus , obesity , and some types of hypertension has been associated with hyperinsulinemia , augmented plasma plasminogen activator inhibitor type 1 ( PAI 1 ) , or both . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The plasma level of plasminogen activator inhibitor type 1 ( PAI 1 ) showed only a slight elevation after treatment . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fibrinolytic system components like tissue plasminogen activators ( t PA ) , and urokinase ( u PA ) , and their inhibitors PAI 1 and PAI 2 were all studied . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Vitronectin ( VN ) stabilizes plasminogen activator inhibitor type 1 ( PAI 1 ) activity and prevents the fibrin ( ogen ) induced acceleration of plasminogen activation by t PA . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Thrombin neutralizes plasminogen activator inhibitor 1 ( PAI 1 ) that is complexed with vitronectin in the endothelial cell matrix . ^^^ Vitronectin endows plasminogen activator inhibitor 1 ( PAI 1 ) , the fast acting inhibitor of both tissue type plasminogen activator ( t PA ) and urokinase type plasminogen activator ( u PA ) , with additional thrombin inhibitory properties . ^^^ A physiological implication of our findings may be related to the mutual neutralization of both PAI 1 and thrombin , providing a new link between plasminogen activation and the coagulation system . ^^^ Evidence is provided that in ECM , procoagulant thrombin may promote plasminogen activator activity by inactivating PAI 1 . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Concentrations of free plasminogen activator inhibitor ( PAI 1 ) and complex of tPA PAI 1 decreased from 8 : 30 to 16 : 30 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We investigated the effect of inhibition of plasminogen activator inhibitor 1 ( PAI 1 ) activity by a murine monoclonal anti human PAI 1 antibody ( MAI 12 ) on in vitro thrombolysis and on in vivo thrombolysis and thrombus extension in an experimental animal model for thrombosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Transforming growth factor beta 1 ( TGF beta 1 ) rapidly increases the expression of junB transcription factor and plasminogen activator inhibitor 1 ( PAI 1 ) and prevents the cell cycle dependent phosphorylation of the RB retinoblastoma susceptibility gene product during late G 1 phase in Mv1Lu lung epithelial cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A mutant of recombinant tissue type plasminogen activator ( rt PA ) , obtained by deletion of residues Lys 296 to Gly 302 [ rt PA del ( K 296 G302 ) ] , was previously shown to be resistant to inhibition by plasminogen activator inhibitor 1 ( PAI 1 ) ( Madison et al , Nature 339 : 721 , 1989 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have investigated the occurrence of type 1 inhibitor of plasminogen activators ( PAI 1 ) in human breast tumors . ^^^ The levels of PAI 1 were found to be correlated with those of urokinase type plasminogen activator ( u PA ) . ^^^ These results , combined with our present findings , present 2 possibilities : either the cancer cells need PAI 1 in order to utilize the u PA mediated pathway of plasminogen activation for invasion and metastasis ; or PAI 1 represents a defense mechanism against tumor invasion . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue type plasminogen activator ( t PA ) antigen , plasminogen activator inhibitor 1 ( PAI 1 ) antigen , and PAI 1 activity were determined in 1 . 25 ml of conditioned medium and t PA and PAI 1 mRNA in the cell extracts of 2 10 10 ( 6 ) HUVE cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Human plasminogen activator inhibitor 1 ( PAI 1 ) is the fast acting inhibitor of tissue plasminogen activator and urokinase and is a member of the serpin family of protease inhibitors . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Analysis of cell free conditioned medium derived from gamma IFN treated cultures by micro enzyme linked immunosorbent assay ( ELISA ) methodologies using uPA and plasminogen activator inhibitor type 1 ( PAI 1 ) specific monoclonal antibodies ( MoAbs ) indicate that the decrease in uPA activity observed by sodium dodecyl sulfate polyacrylamide gel electrophoresis ( SDS PAGE ) zymography is a direct result of a decrease in extracellular uPA antigen and is not a consequence of increased PAI 1 antigen . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We measured antigen levels of 2 kinds of plasminogen activator , tissue type plasminogen activator ( t PA ) and urokinase type plasminogen activator ( UK ) , as well as those of their primary inhibitors , type 1 plasminogen activator inhibitor ( PAI 1 ) and type 2 plasminogen activator inhibitor ( PAI 2 ) , in tissue extracts from benign and malignant breast tumors . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Several studies have demonstrated a reduced fibrinolytic activity in these patients , mainly due to an enhanced activity of plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have reported previously that incubation of HTC rat hepatoma cells with the synthetic glucocorticoid dexamethasone causes a 90 % decrease in tissue type plasminogen activator ( tPA ) activity secondary to a 4 fold increase in plasminogen activator inhibitor 1 ( PAI 1 ) mRNA accumulation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Regulation of the human type 1 plasminogen activator inhibitor ( PAI 1 ) promoter by transforming growth factor beta ( TGF beta ) was studied . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Endotoxin treated rabbits produce high levels of plasminogen activator inhibitor 1 ( PAI 1 ) , which inhibits fibrinolysis by neutralizing endogenous tissue type plasminogen activator ( t PA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A computer simulation was developed to study the regulation of active tissue plasminogen activator ( t PA ) levels in plasma by kinetically modeling t PA secretion , t PA inhibition by plasminogen activator inhibitor type 1 ( PAI 1 ) , and hepatic clearance of t PA , PAI 1 and t PA / PAI 1 complex throughout a simplified human circulatory system . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In order to study the hormonal regulation of plasminogen activator inhibitor 1 ( PAI 1 ) secretion by human capillary cells we used epithelial cells from omental tissue ( HOTMEC ) . ^^^ Tissue plasminogen activator ( t PA ) levels in HOTMEC conditioned medium were 50 fold higher than those of HUVEC , and the PAI 1 secretions were identical in both cell types . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Importance of plasminogen activator inhibitor type 1 ( PAI 1 ) for preventing single chain urokinase plasminogen activator ( scu PA ) conversion into two chain urokinase plasminogen activator ( tcu PA ) in plasma in vitro . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Type 1 inhibitor of plasminogen activators ( PAI 1 ) occurs in purified preparations in a latent form that can be activated with denaturants ; in vivo , latency is prevented by binding to vitronectin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A special attention has been focused in changes in the levels of tissue plasminogen activator ( t PA ) activity and antigen and plasminogen activator inhibitor 1 ( PAI 1 ) as indexes of fibrinolysis capacity , representing parameters of vascular endothelial functions . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Platelet aggregation and the plasma levels / activity of plasminogen activator ( tPA ) and its inhibitor ( PAI 1 ) were determined . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In contrast , the activity of plasminogen activator inhibitor ( PAI 1 ) decreased from 17 + / 2 to 12 + / 1 AU / ml . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The factors for which evidence is most convincing include : plasma fibrinogen , coagulation factor 7 , and an inhibitor of fibrinolysis , namely the plasminogen activator inhibitor PAI 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Recent studies have established that , of the known components of the fibrinolytic system , only tissue type plasminogen activator ( tPA ) and its fast acting inhibitor , plasminogen activator inhibitor 1 ( PAI 1 ) , show a marked circadian variation in plasma . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In addition , we demonstrate that Lp ( a ) regulates endothelial cell synthesis of a major fibrinolytic protein , plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^ In cultured human endothelial cells , Lp ( a ) enhanced PAI 1 antigen , activity , and steady state mRNA levels without altering tissue plasminogen activator activity or mRNA transcript levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Zymographic analysis indicated that PRthr treatment of BAEs decreases urokinase and increases type 1 plasminogen activator inhibitor ( PAI 1 ) activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
There was also a significant lowering of plasma fibrinogen levels and plasminogen activator inhibitor ( PAI 1 ) concentration in non smokers . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue plasminogen activator ( tPA ) and plasminogen activator inhibitor ( PAI 1 ) were measured in citrated plasma samples before and after venous occlusion before and at the end of the study period . tPA activity after venous occlusion and tPA capacity were significantly increased after doxazosin as compared to pretreatment values . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma levels of plasminogen activator inhibitor type 1 ( PAI 1 ) , beta thromboglobulin ( beta TG ) , and fibrinopeptide A ( FPA ) were followed over 24 hours in 30 patients treated with alteplase for acute myocardial infarction . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Univariate statistical analysis showed Lp ( a ) concentration to be associated with fibrinogen concentrations in both sexes ( m : r = 0 . 08 , P less than 0 . 05 ; f : r = 0 . 20 , P less than 0 . 001 ) , but not with euglobulin fibrinolysis activity , tissue type plasminogen activator , plasminogen activator inhibitor type 1 ( PAI 1 ) , or the split products of cross linked fibrin ( d dimer ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Transforming growth factor beta ( TGF beta ) treatment of rat osteoblast rich calvarial cells or of the clonal osteogenic sarcoma cells , UMR 106 01 , resulted in dose dependent inhibition of plasminogen activator ( PA ) activity , and increased production of 3 . 2 kb mRNA and protein for PA inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The activation of plasminogen by T PA PAI 1 complex in the absence of fibrin . ^^^ The activity of tissue plasminogen activator plasminogen activator inhibitor 1 ( t PA PAI 1 ) complex to convert plasminogen to plasmin was examined by using fibrin autography and casein zymography where plasminogen was added or removed for casein layer . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In bivariate correlation analysis , only glucose ( r = 0 . 52 , p less than 0 . 05 ) and triglycerides ( r = 0 . 53 , p less than 0 . 05 ) correlated with changes in plasminogen activator inhibitor type 1 ( PAI 1 ) activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Symptom limited treadmill exercise with thallium 201 myocardial single photon emission CT ( SPECT ) and fibrinolytic examinations ( tissue plasminogen activator antigen : tPA , plasminogen activator inhibitor 1 antigen : PAI 1 ) were performed 2 and 14 weeks after AMI in 13 patients with exercise training and in 12 patients without exercise training . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Human glomerular epithelial cells ( GECs ) in culture synthesize single chain , urokinase type plasminogen activator ( SC uPA ) , tissue type plasminogen activator ( t PA ) , and plasminogen activator inhibitor 1 ( PAI 1 ) and possess specific membrane binding sites for u PA . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The receptor for tissue plasminogen activator ( t PA ) in complex with its inhibitor , PAI 1 , on human hepatocytes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the presence of a molar excess of anti plasminogen activator inhibitor type 1 ( PAI 1 ) antibodies the interiorization rate is similar to that observed with catalytically inhibited u PA , suggesting that PAI 1 molecules can modulate the intracellular accumulation of u PA in this cell line . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We analyzed the effect of IL 1 on the synthesis of collagenase , stromelysin , and tissue inhibitor of metalloproteases ( TIMP ) in human cartilage explants and culture chondrocytes , as well as its effect on the secretion of plasminogen activators ( t PA , u PA ) and inhibitors ( PAI 1 , PAI 2 ) in cartilage explants . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The following fibrinolytic variables were analysed in plasma and related to thromboembolism : tissue plasminogen activator ( t PA ) activity , t PA antigen ( t PA Ag ) , plasminogen activator inhibitor ( PAI 1 ) activity and PAI 1 antigen ( PAI 1 Ag ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The plasminogen activation system in human colon cancer : messenger RNA for the inhibitor PAI 1 is located in endothelial cells in the tumor stroma . ^^^ Fourteen human colon adenocarcinomas were examined by in situ hybridization for the presence of mRNA for plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is sensitive to oxidative inactivation , and it has been suggested that specific oxidation of a methionine residue , Met 347 , situated in the P 1 ' position of the reactive center may be the cause of the inactivation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Distribution of plasminogen activator inhibitor ( PAI 1 ) in tissues . ^^^ Extracts of human tissue were analysed for plasminogen activator inhibitor ( PAI 1 ) antigen and activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Type 1 plasminogen activator inhibitor ( PAI 1 ) is a serine protease inhibitor synthesized by ECs and thought to play a crucial role in the regulation of fibrinolysis . ^^^ PAI 1 is a physiological inhibitor of both tissue type plasminogen activator and urokinase type plasminogen activator , key enzymes in the initiation of fibrinolysis . ^^^ PAI 1 in complex with vitronectin is still accessible to plasminogen activators . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Dexamethasone appeared to suppress the cell surface PA activity by enhancing de novo synthesis of PAI 1 , whereas thrombin suppressed it by inactivating single chain urokinase type plasminogen activators . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The effects of recombinant tissue type plasminogen activator ( rt PA ) and of an inactive mutant of rt PA , obtained by mutagenesis of the active site Ser 478 to Ala ( rt PA Ala 478 ) , on the synthesis and secretion of plasminogen activator inhibitor 1 ( PAI 1 ) by human umbilical vein endothelial cells ( HUVEC ) in culture were studied . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
MelJuso cells produced uPA as well as plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Northern blot analysis showed a significant increase of plasminogen activator inhibitor 1 ( PAI 1 ) mRNA when EGF or TNF was present . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Consistently , however , over a period of 7 years , a high basal euglobulin fibrinolytic activity was observed that was characterized by a high tissue type plasminogen activator ( t PA ) activity , normal t PA antigen , and undetectable plasminogen activator inhibitor type 1 ( PAI 1 ) antigen and activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The relative molecular masses of these species ( 60 to 80 and 110 Kd ) suggest that they represent recombinant human t PA both free and bound to sheep plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In this study , the clearance of t PA , plasminogen activator inhibitor 1 ( PAI 1 ) , and t PA PAI 1 complex was determined in an isolated perfused rat liver system . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
PA inhibitor type 1 ( PAI 1 ) is an efficient inhibitor of tissue type PA ( tPA ) and urokinase type PA ( uPA ) that may therefore be instrumental for the control of plasminogen activation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue plasminogen activator ( t PA ) activity increased ( P less than 0 . 02 ) , and t PA antigen decreased ( P less than 0 . 01 ) , whereas plasminogen activator inhibitor ( PAI 1 ) and fibrinogen were unaffected by metformin treatment . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The work described here demonstrates the synthesis by human articular cartilage of plasminogen activator inhibitor 1 ( PAI 1 ) , a potent inhibitor of the serine protease tissue plasminogen activator ( tPA ) . ^^^ A scheme is presented indicating the probable importance of the serine proteases ( tPA and plasminogen ) and PAI 1 in cartilage degradation . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In contrast , plasminogen activator inhibitor 1 ( PAI 1 ) activity in plasma was elevated in the unstable angina group ( 21 . 67 + / 9 . 52 AU / ml ) as compared with either the stable angina group ( 12 . 01 + / 7 . 06 AU / ml , p less than 0 . 02 ) or the controls ( 12 . 49 + / 8 . 54 AU / ml , p less than 0 . 02 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The effects of 6 months of intensive endurance exercise training on resting tissue type plasminogen activator ( t PA ) activity , plasminogen activator inhibitor type 1 ( PAI 1 ) activity , t PA antigen , and fibrinogen were studied in 10 young ( 24 30 years ) and in 13 old male subjects ( 60 82 years ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor ( PAI 1 ) , and tissue plasminogen activator ( tPA ) antigen and activity were measured before and after venous occlusion . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Urokinase type plasminogen activator and its inhibitor PAI 1 in breast cancer : studies at both protein and mRNA level . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
EC have been demonstrated to release tissue type plasminogen activator ( t PA ) and its rapid inhibitor type 1 plasminogen activator inhibitor ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The present study was performed to elucidate the acute effect of insulin on levels of tissue plasminogen activator ( t PA ) and plasminogen activator inhibitor of endothelial cell type ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Previous nucleotide ( nt ) sequence analysis of the 5 ' flanking DNA of the gene ( PAI 1 ) encoding plasminogen activator inhibitor 1 revealed an extensive region of shared nt sequence identity with the 5 ' flanking region of the gene ( t PA ) encoding tissue type plasminogen activator [ Bosma et al . , J . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
GB binding of 9 AA was also inhibited by prior treatment of sections of tumour tissues with PAI 1 , a protein inhibitor of plasminogen activatory . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Euglobulin fibrinolytic activity ( EFA ) , tissue type plasminogen activator ( t PA ) activity , plasminogen activator inhibitor 1 ( PAI 1 ) activity , plasminogen , alpha 2 antiplasmin ( alpha 2 AP ) , fibrinogen degradation products ( FDP ) , and D dimer were measured pre , intra , and postoperatively . ^^^ There were significant increases in EFA and t PA activity ( p less than 0 . 002 ) , and decreases in plasminogen and alpha 2 AP ( p less than 0 . 0001 ) intraoperatively with respect to baseline values . t PA activity decreased significantly after surgery ( p less than 0 . 002 ) , whereas PAI 1 activity showed a marked increase shortly after operation and on postoperative day 1 ( p less than 0 . 0001 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue type plasminogen activator ( t PA ) and its inhibitor , plasminogen activator inhibitor 1 ( PAI 1 ) , play an important role in regulating the fibrinolytic capacity of plasma . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have shown that synthetic peptides containing the amino acid sequence Asn Arg Arg Leu , derived from the amino acid sequence of the inner loop of the kringle 2 domain of tissue type plasminogen activator ( tPA ) , inhibited complex formation between two chain tPA and plasminogen activator inhibitor 1 ( PAI 1 ) by binding to PAI 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The following fibrinolytic variables were analysed in plasma and related to the different steps of surgery : tissue plasminogen activator ( t PA ) activity , t PA antigen and plasminogen activator inhibitor ( PAI 1 ) activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We determined plasma levels of tissue type plasminogen activator ( t PA ) antigen , urokinase type plasminogen activator ( u PA ) antigen , and activity of the fast acting inhibitor of plasminogen activator ( PAI 1 ) in patients with different stages of liver cirrhosis ( Child A , B , and C ) and in age and sex matched healthy controls to investigate the contribution of the liver to the metabolism of these main components of the fibrinolytic system . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The formation of complexes between human plasminogen activator inhibitor 1 ( PAI 1 ) and sodium dodecyl sulfate : possible implication in the functional properties of PAI 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
These latter cell lines also produced plasminogen activator inhibitor type 1 ( PAI 1 ) and type 2 ( PAI 2 ) mRNA and protein . u PA receptor ( u PA R ) mRNA and binding of radiolabeled u PA was found in all melanoma cell lines . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To assess the postulated role of plasminogen activation in tumor invasion , we have investigated the cellular sites of synthesis for urokinase type ( uPA ) and tissue type ( tPA ) plasminogen activators and their inhibitors ( PAI 1 and PAI 2 ) in two human cutaneous neoplasia that differ in their metastatic potential . ^^^ These observations establish that invasive human malignant cells in vivo can activate plasminogen through uPA production during the early phases of tumor growth ; they also demonstrate that the proteolytic activity of tumor cells can be modulated by the concomitant production of PAI 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The regulation of type 1 plasminogen activator inhibitor ( PAI 1 ) gene expression was studied in vivo employing a murine model system . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The expression of urokinase type plasminogen activator ( u PA ) and its type 1 inhibitor ( PAI 1 ) was examined in vivo in mouse wounds by in situ hybridization and immunohistochemistry . u PA mRNA was present in both basal and suprabasal keratinocytes in the regenerative epithelial outgrowths at the edge of the wounds . ^^^ The localized and regulated expression of u PA and PAI 1 seen in this study may reflect that plasminogen activation plays a role in the migration of keratinocytes and connective tissue cells during reepithelialization and tissue remodeling in wound healing . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Since disseminated intravascular coagulation ( DIC ) may directly reflect the abnormal regulation of the fibrinolytic system by endothelial cells , we have measured the levels of tissue type plasminogen activator ( t PA ) , type 1 PA inhibitor ( PAI 1 ) and t PA . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Two protease inhibitors in human plasma play a key part in the control of thrombosis : antithrombin inhibits coagulation and the plasminogen activator inhibitor PAI 1 inhibits fibrinolysis , the dissolving of clots . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
HUVEC responded to exposure to 42 degrees C with a time dependent increase in plasminogen activator inhibitor type 1 ( PAI 1 ) activity and antigen accompanied by a four to fivefold increase in PAI 1 specific m RNA and a decrease in tissue type plasminogen activator ( t PA ) antigen . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Depressed fibrinolytic activity was associated with increased antiplasmin activity and plasminogen activator inhibitor 1 ( PAI 1 ) while PAI 2 concentrations approximated those of control samples and did not change during evolving ARDS . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The concentrations of cathepsin D ( Cath D ) , urokinase ( uPA ) and two plasminogen activator inhibitors ( PAI 1 and PAI 2 ) were analysed in the cytosols of 130 human mammary tumours ( 43 benign tumours and 87 primary and unilateral breast carcinomas ) . uPA , PAI 1 and PAI 2 levels were measured by antigenic immunoassays and Cath D by immunoradiometric assay . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
It was recently demonstrated that patients with coronary heart disease have defects in plasma fibrinolysis due to increased plasminogen activator inhibitor 1 ( PAI 1 ) levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Concomitantly the concentrations of the fast acting plasminogen activator inhibitor type 1 ( PAI 1 ) in plasma increased . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
GM CSF and G CSF ( 1 ng / mL to 1 microgram / mL ) had no effect on the expression of either tissue plasminogen activator ( tPA ) or plasminogen activator inhibitor 1 ( PAI 1 ) by endothelial cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The present study evaluates the effect of retinoic acid on the synthesis of tissue type plasminogen activator ( t PA ) and of plasminogen activator inhibitor 1 ( PAI 1 ) by cultured human umbilical vein endothelial cells ( HUVEC ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The extracellular localizations of urokinase type plasminogen activator ( uPA ) , tissue type plasminogen activator ( tPA ) , and plasminogen activator inhibitor 1 ( PAI 1 ) were examined in cultured bovine capillary endothelial cells ( BCEs ) by an immunofluorescence method using BCEs treated with or without saponin and focal contact preparations . ^^^ These findings suggest that uPA and PAI 1 are located under BCEs participating in the regulation of proteolytic activities provoked by plasminogen PAs plasmin system in vivo . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Recent studies using assays specific for the components of the fibrinolytic system have shown that the effects of metformin are to cause a fall in plasma levels of the fibrinolytic inhibitor , plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Such a defect is mainly characterized by increased plasma levels of an inhibitor of fibrinolysis the plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Both activation of platelets and elevation of plasminogen activator inhibitor type 1 ( PAI 1 ) activity in plasma have been associated with acute myocardial infarction . ^^^ However , when recanalization of completely occluded vessels was induced with tissue type plasminogen activator ( t PA ) , plasma PAI 1 increased more markedly ( from 5 . 6 + / 0 . 7 to 112 . 8 + / 22 . 3 AU / ml , n = 11 ) , exceeding the increase after corresponding intervals in animals in which t PA failed to induce recanalization ( from 5 . 2 + / 1 . 1 to 28 . 3 + / 6 . 1 AU / ml , n = 6 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In our present study , we measured plasminogen activator inhibitor 1 ( PAI 1 ) levels in plasmas from patients with various tumors . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We measured antigen levels of two kinds of plasminogen activators , tissue type plasminogen activator ( t PA ) and urokinase type plasminogen activator ( UK ) , as well as their primary inhibitor , type 1 plasminogen activator inhibitor ( PAI 1 ) in the tissue extracts of benign and malignant breast tumors . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
High levels of von Willebrand factor ( vWF ) , plasminogen activator inhibitor type 1 ( PAI 1 ) and tissue type plasminogen activator ( t PA ) antigens were also recorded in some patients with systemic bleeding with or without incoagulable blood . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
ICI 200 , 880 administration increased elastase inhibitory activity without affecting t PA and plasminogen activator inhibitor ( PAI 1 ) activities . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Recurrent postoperative bleeding in a previously healthy man with a moderate prolongation of PT and PTT which did not correct with vigorous fresh frozen plasma infusion was identified as a unique abnormality of the fibrinolytic system : a combination of an excess of tissue plasminogen activator ( t PA ) at 300 % of normal activity accompanied by a concurrent deficiency of plasminogen activator inhibitor 1 activity ( PAI 1 ) of 10 20 % of normal activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In this study , the authors determined the activity and antigen levels of u PA and t PA , and their inhibitors , plasminogen activator inhibitors types 1 and 2 ( PAI 1 and PAI 2 ) , in normal mucosa , adenomatous polyps , and adenocarcinomas of the human colon . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Inverse relationship between cortisol excretion rate and plasminogen activator inhibitor 1 ( PAI 1 ) antigen and activity in premenopausal obese women . ^^^ The present study was undertaken in order to investigate the possibility of a relationship between plasminogen activator inhibitor 1 ( PAI 1 ) and cortisol excretion rate in 15 obese women . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Human umbilical vein endothelial cells ( HUVEC ) were cultured in the presence of various glycosaminoglycans and the intracellular levels of tissue plasminogen activator ( tPA ) and plasminogen activator inhibitor 1 ( PAI 1 ) measured by ELISA . 10 IU / ml heparin ( 90 micrograms / ml ) brought about a significant ( 20 fold ) increase in intracellular tPA levels over the 6 day culture period ; intracellular PAI 1 levels were significantly decreased ( by 60 70 % ) and culture growth rate promoted . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have studied the effect of plasminogen activator inhibitors PAI 1 and PAI 2 on the binding of urokinase type plasminogen activator ( u PA ) to its receptor in the human choriocarcinoma cell line JAR . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The triglyceride dependent factors , plasminogen activator inhibitor ( PAI 1 ) and factor 7 phospholipid complex , were not affected . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Regulation of plasminogen activation by plasminogen activator inhibitor type 1 ( PAI 1 ) is a critical feature of many biological processes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
One was type 1 plasminogen activator inhibitor ( PAI 1 ) , because the 125I urokinase containing complexes were immunoprecipitated with anti PAI 1 antibodies . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Recombinant human interleukin 1 inhibits plasminogen activator inhibitor 1 ( PAI 1 ) production by human articular cartilage and chondrocytes . ^^^ Human articular cartilage and chondrocyte monolayers in culture constitutively produced plasminogen activator inhibitor 1 ( PAI 1 ) protein and mRNA , as assessed by a specific enzyme linked immunosorbent assay and Northern blotting analysis , respectively . ^^^ Since IL 1 has been shown before to cause human cartilage destruction and a correlated change in plasminogen activator activity , it could be that a concomitant reduction in PAI 1 levels by IL 1 may be significant in the control of these changes in cartilage . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We recently hypothesized that after pharmacologically induced coronary thrombolysis , increased activity of plasminogen activator inhibitor type 1 ( PAI 1 ) retards recanalization , contributes to early reocclusion , or both . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Crystals of bacterially expressed plasminogen activator inhibitor ( PAI 1 ) suitable for 10 ray diffraction analysis have been obtained from 8 % ( w / v ) PEG 1500 , pH 8 . 25 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Secretion of plasminogen activator inhibitor type 1 ( PAI 1 ) by cultured cells is increased after exposure to specific cytokines and growth factors . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor ( PAI 1 ) rapidly inactivates tissue plasminogen activator ( t PA ) and urokinase ( UK ) with nearly identical association rate constants . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
However , in the culture medium of platelet treated aortic EC , a new lysis band of 92 kDa appeared with no associated amidolytic activity suggesting that the 48 kDa plasminogen activator secreted by the aortic EC after treatment with platelets is complexed to the inhibitor PAI 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Taken together with our previous observations , these results demonstrate that the inhibition of endothelial sprout formation occurs concomitantly with an increase in the production of PAI 1 , a physiological plasminogen activator inhibitor . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The inhibitor reacting with a tumour cell surface protease can be exchanged with plasminogen activator inhibitor ( PAI 1 ) . ^^^ A cytoplasmic extract from the tumour tissue , and a purified inhibitor of plasminogen activator ( PAI 1 ) were shown to be exchangeable components of the enzyme inhibitor complex on the fixed tumour cell surfaces . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In addition , hypertension is linked to impaired fibrinolysis and elevated levels of the plasminogen activator inhibitor of endothelial type ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Immunogold EM was employed to compare the distribution of type 1 plasminogen activator inhibitor ( PAI 1 ) on the surface of agonist activated human umbilical vein endothelial cells ( HUVECs ) with that of control , unactivated cells . ^^^ Immunoabsorption of the rabbit anti PAI 1 with purified PAI 1 , or treatment of HUVECs with tissue type plasminogen activator ( 2 . 5 micrograms / ml , 2 h , 4 degrees C ) reduced the amount of staining both on the apical surface and in the extracellular matrix of agonist activated HUVECs by 80 95 % . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Selective assay methods show that almost invariably the fibrinolytic activity of these patients is depressed either following increased levels of fibrinolytic inhibitors ( mainly plasminogen activator inhibitor 1 or PAI 1 ) and / or decreased levels of a plasminogen activator ( tissue plasminogen activator or t PA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
IX , von Willebrand Factor , protein C , tissue type plasminogen activator ( tPA ) , plasminogen activator inhibitor 1 ( PAI 1 ) , beta thromboglobulin , platelet factor 4 , fibrinopeptide A , plasmin alpha 2 antiplasmin complex and FDP . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The interactions between exogenously added tissue type plasminogen activator ( t PA ) and the active form of type 1 plasminogen activator inhibitor ( PAI 1 ) produced by and present in cultured human umbilical vein endothelial cells ( HUVECs ) were investigated . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma levels of free plasminogen activator inhibitor 1 ( PAI 1 ) and complex of t PA PAI 1 decreased from 9 : 30 h to 10 : 00 h ( p less than 0 . 02 ) and to 12 : 30 h ( p less than 0 . 01 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The structural events taking place during the reaction between PAI 1 ( plasminogen activator inhibitor 1 ) and the plasminogen activators sc tPA ( single chain tissue plasminogen activator ) and tc tPA ( two chain tissue plasminogen activator ) were studied . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In 22 human tumor cell lines the regulation of production of plasminogen activators urokinase ( u PA ) and tissue type ( t PA ) and their inhibitors PAI 1 and PAI 2 was studied . ^^^ In 11 of the 22 cells PAI 1 mRNA and in 6 of the 22 cells PAI 2 mRNA was found , pointing to a possible role of plasminogen activator inhibitors in the tumor related plasminogen activator activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The formation and release of covalent complexes between tissue type plasminogen activator ( t PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) limits the application of equilibrium radioligand binding analysis to characterize the interaction between t PA and human umbilical vein endothelial cell ( HUVEC ) monolayers . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Here we report that most of the specific binding of 125I t PA to our HUVEC cultures is accounted for by binding to ( 1 ) plasminogen activator inhibitor type 1 ( PAI 1 ) , a t PA inhibitor produced in abundance by HUVECs ; and ( 2 ) specific binding sites present on the plastic culture surface . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We report here that human omental tissue mesothelial cells in vitro produce large amounts of tissue type plasminogen activator ( t PA ) , together with type 1 and 2 plasminogen activator inhibitor ( PAI 1 and PAI 2 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma samples of tissue plasminogen activator ( tPA ) antigen , and plasminogen activator inhibitor ( PAI 1 ) activity were obtained for the assay . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor type 1 ( PAI 1 ) was identified in extracts of Lewis lung carcinoma , and its immunohistochemical localization was studied together with that of urokinase type ( u PA ) and tissue type ( t PA ) plasminogen activators . ^^^ The results are consistent with an assumption that the plasminogen activation system , and particularly u PA and PAI 1 , plays a role in regulation of breakdown of extracellular matrix proteins during invasive growth in this carcinoma . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We show that dLPS can inhibit the ability of LPS , but not TNF , to elicit the expression of plasminogen activator inhibitor 1 ( PAI 1 ) , prostacyclin , and PGE 2 by human umbilical vein endothelial cells . dLPS also prevented the accumulation of specific PAI 1 mRNA in response to LPS , but not to TNF . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fibrinolysis is regulated in part by the interaction between tissue type plasminogen activator ( t PA ) and plasminogen activator inhibitor 1 ( PAI 1 , a serine protease inhibitor of the serpin family ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The relationships between tissue plasminogen activator ( tPA ) , its fast acting inhibitor ( PAI 1 ) and euglobulin clot lysis time ( ELT ) were investigated with healthy volunteers ' plasma . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To evaluate possible hormonal regulators of the diurnal rhythm in fibrinolytic activity , we measured tissue plasminogen activator ( t PA ) activity , plasminogen activator inhibitor activity ( PAI 1 ) , t PA antigen , insulin , cortisol , and catecholamines in 6 healthy males ( age 34 + / 5 ) every 2 hours for 24 hours . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Northern and western analyses showed that the reduction in protease activity resulted from an increased level of plasminogen activator inhibitor 1 ( PAI 1 ) mRNA and protein . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Preincubation of tPA with plasminogen activator inhibitor 1 ( PAI 1 ) was found to have little effect on binding , suggesting that tPA interacts at sites distinct from surface bound PAI 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The influence of diacylglycerols , which are physiological activators of protein kinase C , on the production of tissue type plasminogen activator ( tPA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) by human umbilical vein endothelial cells ( HUVEC ) was studied in order to gain insight into the regulation of fibrinolysis by these cells . 1 , 2 dioctanoyl sn glycerol ( diC 8 ) stimulated tPA production in a dose and time dependent manner . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Effect of PAI 1 levels on the molar concentrations of active tissue plasminogen activator ( t PA ) and t PA / PAI 1 complex in plasma . ^^^ We determined the in vivo molar concentrations of active tissue plasminogen activator ( t PA ) , active plasminogen activator inhibitor type 1 ( PAI 1 ) , and t PA / PAI 1 complex . t PA activity was measured in plasma stabilized by immediate acidification . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This study was designed to investigate t PA activity , t PA antigen and plasminogen activator inhibitor 1 ( PAI 1 ) antigen levels in the CI patients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have undertaken a structural and functional analysis of recombinant plasminogen activator inhibitor type 1 ( PAI 1 ) produced in Escherichia coli using site directed mutagenesis and immunochemistry . ^^^ Mutations in both the reactive center P 1 and P 1 ' residues ( Arg Met ) and a putative secondary binding site for plasminogen activators on PAI 1 have been engineered to assess their functional effects . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) , a natural plasminogen activator inhibitor , abolished tPA induced HUVEcell migration . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The release of plasminogen activator inhibitor 1 antigen ( PAI 1 : Ag ) was also stimulated by thrombin ; this stimulation was inhibited only by the combination of HC 2 and dermatan sulfate . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The effect of anoxia and reoxygenation on the synthesis and secretion of tissue type plasminogen activator ( t PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) was studied in primary cultures of human umbilical vein endothelial cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The most important of these is endothelial cell plasminogen activator inhibitor ( PAI 1 ) , a member of the serine protease inhibitor ( serpin ) gene family . ^^^ We have previously demonstrated that mutation of arginine 304 of t PA to a glutamic acid residue drastically reduces the rate of interaction between the enzyme and its suicide substrate , PAI 1 , without affecting the reactivity of the enzyme toward its normal substrate , plasminogen ( Madison , E . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The correlation between the activity of tissue plasminogen activator ( TPA ) , levels of tissue plasminogen activator inhibitor ( PAI 1 ) antigen and serum lipids in healthy subjects ] . ^^^ In the present study , the correlation between the activity of tissue plasminogen activator ( TPA ) , the levels of tissue plasminogen activator inhibitor ( PAI 1 ) and serum lipids ( TC , TG , beta Lp , HDLC , LDLC and apolipoproteins ) were studied in 102 healthy subjects . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We report here the effect of purified human alpha thrombin on the synthesis of tissue type plasminogen activator ( t PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) by cultured human mesangial cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The daytime fluctuation of the fibrinolytic activity and the antigen levels of tissue plasminogen activator ( tPA ) and plasminogen activator inhibitor 1 ( PAI 1 ) in plasma were analyzed in normal male and female volunteers . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The circadian fluctuation of the fibrinolytic activity and the antigen levels of tissue plasminogen activator ( tPA ) and plasminogen activator inhibitor 1 ( PAI 1 ) in plasma were analyzed in normal male and female volunteers . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Before and at peak exercise we measured the plasminogen activator activity ( PAA ) in the euglobulin fraction of plasma by an amidolytic method and the concentrations of tissue plasminogen activator ( t PA ) , activator inhibitor complex plasminogen activator inhibitor 1 ( PAI 1 ) complexed with t PA and total PAI 1 by enzyme immunoassay . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The statistical association between tissue plasminogen activator ( t PA ) activity , antigen , plasminogen activator inhibitor 1 ( PAI 1 ) antigen and lipids levels in blood samples used for medical check ups in 111 volunteers attending hospital for health examinations was examined . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have investigated the effect of sodium nitroprusside ( NP ) and glyceryl trinitrate ( GTN ) on fibrinolysis in anaesthetized rabbits ex vivo and in vitro by measurement of euglobulin clot lysis time ( ECLT ) , plasma levels of tissue plasminogen activator ( t PA ) activity , plasma t PA antigen levels and plasminogen activator inhibitor ( PAI 1 ) activity . 2 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue type plasminogen activator and its inhibitor ( PAI 1 ) in plasma in cases of non insulin dependent diabetes mellitus ( NIDDM ) ] . ^^^ Parameters of fibrinolysis , including plasminogen , alpha 2 plasmin inhibitor ( alpha 2 PI ) , tissue type plasminogen activator ( t PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) antigens , and fibrinogen were assayed in 53 patients ( 28 women and 27 men ; mean age : 64 years , age range : 32 87 years ) with non insulin dependent diabetes mellitus ( NIDDM ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor type 1 ( PAI 1 ) can modify fibrinolytic activity in vitro and in vivo . ^^^ The present study was performed to determine whether pharmacologic concentrations of tissue type plasminogen activator ( t PA ) can initiate negative feedback by stimulating PAI 1 synthesis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The regulation of tissue plasminogen activator ( tPA ) and plasminogen activator inhibitor 1 ( PAI 1 ) synthesis was studied in cultured human mesothelial cells derived from omentum ( HOMC ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Gene transfer techniques were utilized to evaluate the role of urokinase type plasminogen activator ( uPA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) in enhancing or preventing the expression of the invasive malignant phenotype , respectively . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
It was possible by using polyclonal antibodies to plasminogen activator inhibitor type 1 ( PAI 1 ) and purified plasminogen activator inhibitor type 1 to confirm that the 46 kD protein purified and characterized here was PAI 1 . ^^^ Since the induction of PAI 1 by dexamethasone was very extensive , it is possible that glucocorticoids regulate proteolysis and fibrinolysis in vivo by increasing the amount of the inhibitor of plasminogen activator and thus preventing the activation of plasminogen to plasmin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma levels of thrombin antithrombin 3 complex ( TAT ) , plasmin alpha 2 plasmin inhibitor complex ( PAP ) , von Willebrand factor antigen ( vWF : Ag ) plasminogen activator antigen ( PA ) and plasminogen activator inhibitor 1 antigen ( PAI 1 ) , were determined in 110 patients with arterial thromboembolic diseases within 4 weeks after attack ( Th ; 41 cases with myocardial infarction and 69 with cerebral infarction ) , 67 patients with various types of carcinoma ( Ca ; 31 cases without metastasis and 36 with metastasis ) and 50 age matched healthy individuals ( Co ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To estimate the extent of the release of plasminogen activator inhibitor type 1 ( PAI 1 ) from platelets following their accidental activation in vitro during blood collection , we studied the antigen levels of PAI 1 and beta thromboglobulin ( beta TG ) in plasma and sera from 38 healthy volunteers . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The sensitivity of a number of serine protease inhibitors ( serpins ) , ( eg . alpha 1 proteinase inhibitor ( alpha 1PI ) and plasminogen activator inhibitor 1 ( PAI 1 ] to oxidative inactivation has been attributed to oxidation of reactive site methionine residues and / or tertiary structural modifications . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
HTC rat hepatoma cells synthesize and secrete tissue type plasminogen activator ( tPA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Messenger RNA for plasminogen activator inhibitor , type 1 ( PAI 1 ) has been detected in RNA extracts from rat peritubular myoid cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Complexes between tissue type plasminogen activator ( t PA ) and its rapidly acting inhibitor plasminogen activator inhibitor type 1 ( PAI 1 ) are bound , internalized , and degraded by HepG 2 cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have analyzed the role of plasminogen activator inhibitor type 1 ( PAI 1 ) in the regulation of tumor cell mediated extracellular matrix degradation . ^^^ This inhibition was correlated with an increase in PAI 1 antigen expression , whereas urinary type plasminogen activator ( u PA ) secretion was unaffected . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Both calvarial osteoblasts and osteogenic sarcoma cells were shown by Western blotting and reverse fibrin autography to produce plasminogen activator inhibitor 1 ( PAI 1 ) , the production of which was increased by LIF treatment . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The rapidly acting inhibitor of plasminogen activators , PAI 1 , was produced intracellularly in Saccharomyces cerevisiae by using the ADH 2 promoter to drive the expression of the human PAI 1 cDNA . ^^^ Hence , this study demonstrates that expression of human PAI 1 in yeast is a viable strategy for the production of ample quantities of this key modulator of plasminogen activator mediated proteolysis . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A recombinant form of plasminogen activator inhibitor 1 ( rPAI 1 ) has been purified from lysates of pCE 1200 , a bacterial expression vector containing the full length PAI 1 gene , by utilizing sequential anion exchange and cation exchange chromatography on Q Sepharose and S Sepharose columns . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Characterization and purification of a secreted plasminogen activator inhibitor ( PAI 1 ) induced by transforming growth factor beta 1 in normal rat kidney ( NRK ) cells : decreased PAI 1 expression in transformed NRK cells . ^^^ This protein was related to type 1 plasminogen activator inhibitor ( PAI 1 ) on the basis of molecular mass , activity in the presence of sodium dodecyl sulfate , immunoprecipitation by antibodies to PAI 1 , and N terminal sequence analysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
TPA treated K 562 cells also synthesize and secrete platelet derived growth factor ( PDGF ) , transforming growth factor beta 1 ( TGF beta 1 ) , urokinase plasminogen activator ( u PA ) and its specific inhibitor , type 1 plasminogen activator inhibitor ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We found an intraperitoneal fibrinogen cleavage and thrombin antithrombin 3 complex formation leading to increased levels of fibrinopeptide A ( FPA : 33 . 3 + / 7 . 0 ng / ml ) and thrombin antithrombin 3 complex ( TAT : 4 . 7 + / 0 . 4 ng / ml ) in plasma by mass transfer from dialysate to plasma . t PA ( tissue plasminogen activator ) and PAI 1 ( plasminogen activator inhibitor type 1 ) concentrations in plasma were within the normal range . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The platelet and plasma pools of plasminogen activator inhibitor ( PAI 1 ) vary independently in disease . ^^^ The relative importance and behaviour of plasma and platelet plasminogen activator inhibitor ( PAI 1 ) in disease has not hitherto been examined . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The pharmacokinetics of the activated and latent forms of plasminogen activator inhibitor 1 ( PAI 1 ) isolated from HT 1080 fibrosarcoma cells ( HT 1080 PAI 1 ) and a nonglycosylated form of human PAI 1 isolated from a yeast expression system ( rPAI 1 ) were followed in the rabbit . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fibrinogen and endothelial type of plasminogen activator inhibitor 1 ( PAI 1 ) were significantly elevated in the obese women with a high WHR compared with the obese women with a low WHR or with both groups of lean women . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
By use of both normal and SV 40 T antigen immortalized cells , it was found that treatment with TGF beta 1 transiently increases mRNA levels for urokinase ( uPA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) approximately 5 and 50 fold , respectively , within 4 h . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Human non small lung cancer cell lines HS 24 ( established from a primary squamous cell carcinoma ) and SB 3 ( established from a metastasis of a primary adenocarcinoma of the lung into the adrenal gland ) were analysed for the proteinases tissue type plasminogen activator ( tPA ) , urokinase type plasminogen activator inhibitor ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Urokinase activity is regulated by the specific endogenous plasminogen activator inhibitors type 1 ( PAI 1 ) and type 2 ( PAI 2 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Conformational differences between latent and active plasminogen activator inhibitor , PAI 1 : a spectroscopic study . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This decreased fibrinolytic function is to a major extent explained by the presence of high plasma levels of plasminogen activator inhibitor 1 ( PAI 1 ) and is most common in patients with hyperlipoproteinemias type IIB and 4 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Human umbilical vein endothelial cells cultured on a collagen lattice were used to study the effects of the interaction between human monocytes and endothelial cells on the production of type 1 plasminogen activator inhibitor ( PAI 1 ) by endothelial cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
High level synthesis of biologically active human plasminogen activator inhibitor type 1 ( PAI 1 ) in Escherichia coli . ^^^ Segments of a cDNA encoding human plasminogen activator inhibitor type 1 ( PAI 1 ) were subcloned into a highly regulated and inducible Escherichia coli expression system . ^^^ A plasmid encoding the mature form of human endothelial PAI 1 produced a functional recombinant molecule , as indicated by its ability to inhibit tissue plasminogen activator ' s enzymatic activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have determined the plasma concentrations of types 1 and 2 of plasminogen activator inhibitor ( PAI 1 and PAI 2 ) , tumor necrosis factor ( TNF alpha ) and endotoxin in 47 patients with bacterial infection ( 22 patients presented with positive blood cultures ) . ^^^ Our results suggest that PAI 1 , but not PAI 2 , is the main plasminogen activator inhibitor in human sepsis . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have reported that glucocorticoids and cyclic nucleotides regulate tissue type plasminogen activator activity in HTC rat hepatoma cells primarily by modulating plasminogen activator inhibitor ( PAI 1 ) gene expression . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The three 44 kD proteins were recognized by antisera raised against endothelial type plasminogen activator inhibitor ( PAI 1 ) . ^^^ Dexamethasone treatment of HUVE and RCME cells reduced cellular and secreted plasminogen activator activity , but no significant effect of dexamethasone on PAI 1 activity in conditioned media could be demonstrated . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Influence of metoprolol CR / ZOK on plasminogen activator inhibitor ( PAI 1 ) in man : a pilot study . ^^^ The effect of metoprolol CR / ZOK ( controlled release ) 100 200 mg daily , on plasminogen activator inhibitor activity ( PAI 1 ) in plasma was measured . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Patients defined as having fulminant septicemia ( n = 13 ) with high ( greater than 700 ng / L ) levels of endotoxin ( LPS ) in plasma and severe coagulopathy , had significantly lower functional levels of plasminogen ( P less than 0 . 05 ) and alpha 2 antiplasmin ( P less than 0 . 01 ) and higher antigen levels of plasminogen activator inhibitor 1 ( PAI 1 ) ( P less than 0 . 01 ) , and fibrin degradation products ( FDP ) ( P less than 0 . 01 ) , but not of PAI 2 ( P greater than 0 . 1 ) as compared with less severely ill patients ( meningitis and meningococcemia ) ( n = 25 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Measurement of plasminogen activator inhibitor 1 ( PAI 1 ) in plasma with various monoclonal antibody based enzyme linked immunosorbent assays . ^^^ Four monoclonal antibodies , MA 7D4 , MA 7F5 , MA 12A4 and MA 15H12 , were raised against human plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^ MA 7D4 was used previously as capture antibody in combination with MA 7F5 conjugated to horseradish peroxidase ( 7F5 HRP ) to construct an ELISA which was 12 times more sensitive towards free PAI 1 as compared to PAI 1 in complex with human tissue type plasminogen activator ( t PA ) ( Blood 71 : 220 225 , 1988 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Elevated fibrinogen and plasminogen activator inhibitor ( PAI 1 ) in hypertension are related to metabolic risk factors for cardiovascular disease . ^^^ The relationship between hypertension , glucose metabolism , fibrinogen and plasminogen activator inhibitor of endothelial cell type ( PAI 1 ) was studied under conditions in which the influence of obesity and adipose tissue distribution ( waist / hip ratio ) were controlled . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
There were no differences in euglobulin lysis time ( ELT ) , tissue plasminogen activator ( t PA ) antigen , and plasminogen activator inhibitor type 1 ( PAI 1 ) antigen between the study group and the control group . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The activities of these key regulatory enzymes are directly neutralized by their primary endogenous inhibitor , plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
An important plasminogen activator inhibitor ( PAI 1 ) is present in plasma and concentrated in alpha granules of platelets . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In order to assess the actual degree of activation of the coagulation and fibrinolytic systems in diabetics , plasma levels of thrombin antithrombin 3 complex ( TAT ) and plasmin alpha 2 plasmin inhibitor complex ( PAP ) were measured together with tissue type plasminogen activator ( t PA ) and plasminogen activator inhibitor ( PAI 1 ) in 18 patients with DM ( three patients with type 1 DM and 15 with type 2 DM ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The present study was undertaken to determine the sensitivity of urokinase receptor directed proteolysis to the type 1 plasminogen activator inhibitor ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Biol . 9 : 124 134 , 1989 ) reveals that it encodes plasminogen activator inhibitor 1 ( PAI 1 ) , a regulator of extracellular proteolysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To delineate interactions of infused tissue type plasminogen activator ( t PA ) with inhibitors in plasma and their impact on fibrinolytic activity , serial plasma samples from patients with acute myocardial infarction and from normal rabbits given infusions of t PA were assayed for t PA antigen , activity of `` fast acting ' ' plasminogen activator inhibitor ( PAI 1 ) , and the presence and nature of t PA inhibitor complexes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Oxidative inactivation of alpha 1 proteinase inhibitor ( A 1 P1 ) and plasminogen activator inhibitor 1 ( PAI 1 ) , both members of the serine protease inhibitor ( serpin ) superfamily , using mild oxidation conditions has been already demonstrated . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have examined the effect of phorbol esters and cAMP elevating compounds on tissue plasminogen activator ( tPA ) and plasminogen activator inhibitor 1 ( PAI 1 ) secretion . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The plasminogen activator inhibitor ( PAI 1 ) from endothelial cells is a potentially important regulator of plasminogen activator activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
During stimulation of washed platelets with various concentrations of thrombin , the nearly concomitant release of VN and plasminogen activator inhibitor 1 ( PAI 1 ) together with platelet factor 4 indicated the association of VN with inner platelet storage granules . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Stability of plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The 48 kDa protein was identified as plasminogen activator inhibitor ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Determination of plasminogen activator inhibitor 1 ( PAI 1 ) in plasma using two different anticoagulants and methods . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Patients with unstable coronary artery disease were randomly treated either with a combination therapy consisting of nitrates and calcium channel blockers without or with addition of clinical grade heparin administered subcutaneously ; in order to evaluate the effect of heparin treatment on the fibrinolytic system , tissue plasminogen activator ( t PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) plasma levels were related to the clinical course of the disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma concentrations of tissue type plasminogen activator ( t PA ) , urokinase ( u PA ) , plasminogen activator inhibitor 1 ( PAI 1 ) and PAI 2 were studied in 53 patients with liver deficiency caused by chronic alcoholism ( n = 40 ) , viral hepatitis ( n = 10 ) or malignant disease of the liver ( n = 3 ) and compared to that of a control group ( n = 20 ) of healthy subjects . u PA and PAI 1 levels were significantly increased in all patients with chronic alcoholism , whereas high t PA was only observed in combination with disturbed liver function tests or with liver cirrhosis ( two and six fold above control values , respectively ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The concentration of tissue plasminogen activator ( t PA ) , plasminogen activator inhibitor 1 ( PAI 1 ) and the complex of t PA and PAI 1 ( t PA PAI 1 complex ) were measured using an enzyme immunoassay , where the first antibody was monoclonal antibody against PAI 1 and the second one was polyclonal anti t PA Fab ' antibody . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue plasminogen activator ( t PA ) regulation of type 1 plasminogen activator inhibitor ( PAI 1 ) secretion by WI 38 human fibroblasts was investigated utilizing a specific ELISA to measure PAI 1 antigen levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor type 1 ( PAI 1 ) was identified in extracts of rat adrenal medulla , and its immunohistochemical localization was studied together with that of tissue type plasminogen activator ( t PA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue plasminogen activator ( tPA ) activity in blood and blood plasma has been difficult to determine because it is unstable , especially in subjects with high levels of plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) inhibits both tissue type plasminogen activator ( tPA ) and urokinase type plasminogen activator ( uPA ) and , therefore , is an important regulator of plasminogen activation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Several blood clotting factors were studied ; von Willebrand factor ( VWF ) , fibrinogen , tissue plasminogen activator ( t PA ) and its inhibitor ( PAI 1 ) and factor 7 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
At rest , essential arterial hypertensives were characterized by increased levels of circulating tissue plasminogen activator , associated with an increased activity of its specific inhibitor , the PAI 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Aspirin ( 650 mg / d 10 2 ) caused no change in resting levels of t PA antigen ( t PA : Ag ) or activity , plasminogen activator inhibitor 1 antigen ( PAI 1 : Ag ) , or activity or t PA PAI 1 complexes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Previous studies with these cells demonstrated their capacity for specific catabolism of t PA in a system modulated by plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Trace amounts of tissue type plasminogen activator ( t PA ) complexed to a plasminogen activator inhibitor type 1 ( PAI 1 ) were identified with specific antibodies . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Furthermore , enhancement of the extrinsic fibrinolytic system is easily explained by the action of activated PC , which counteracts plasminogen activator inhibitor ( PAI 1 ) , to cause enhancement of t PA activity . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The involvement of the erythropoietin ( EPO ) , plasminogen activator inhibitor type 1 ( PAI 1 ) , and multi drug resistance ( MDR 2 ) genes located in chromosomal region 7q21 22 was studied in patients with myeloid disorders and with or without a chromosome 7 abnormality . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
DNA for bovine type 1 plasminogen activator inhibitor ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We describe a novel application of the polymerase chain reaction ( PCR ) technique of DNA amplification to study the exon intron structure of the rat plasminogen activator inhibitor ( PAI 1 ) gene . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Structure and expression of the human gene encoding plasminogen activator inhibitor , PAI 1 . ^^^ The gene ( pai 1 ) encoding human plasminogen activator inhibitor , PAI 1 was cloned from a lambda EMBL 3 genomic library and was found to span approx . 12 kb and to contain eight introns . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Cloned cDNA sequence for the human mesothelial protein ' mesosecrin ' discloses its identity as a plasminogen activator inhibitor ( PAI 1 ) and a recent evolutionary change in transcript processing . ^^^ Comparison of mesosecrin cDNA sequences with the recently published sequence for plasminogen activator inhibitor 1 ( PAI 1 ) cloned from cDNA libraries of endothelial and other cell types revealed that mesosecrin and PAI 1 are the same protein . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The prognostic value of plasminogen activator inhibitor type 1 ( PAI 1 ) in septic shock was investigated in 52 patients with septic shock . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Clinical studies have shown that plasma insulin levels are closely related to plasma plasminogen activator inhibitor 1 ( PAI 1 ) levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
They synthesize and secrete tissue type plasminogen activators ( t PA ) , urinary type plasminogen activators ( u PA ) , as well as plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The plasminogen activator inhibitor PAI 1 , which plays an important role in the regulation of fibrinolysis , was also studied during treatment . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is the primary inhibitor of tissue type plasminogen activator and thus performs an essential role in the regulation of the fibrinolytic process . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The accumulation of plasminogen activator inhibitor type 1 ( PAI 1 ) in CM from butyrate treated cells varied only moderately . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To identify factors potentially influencing expression of type 1 plasminogen activator inhibitor ( PAI 1 ) , we characterized the human tissue specific distribution of PAI 1 mRNA and the influence of epidermal growth factor ( EGF ) on expression of steady state levels of PAI 1 mRNA and secretion of PAI 1 by Hep G 2 cells . ^^^ Expression of PAI 1 mRNA was inversely related to the distribution of tissue type plasminogen activator mRNA ( 2 . 3 kilobases ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
No evidence for endothelial release of prostacyclin was obtained as judged from urinary excretion of 2 , 3 dinor 6 keto PGF 1 alpha ( a major prostacyclin metabolite ) , and plasma concentrations of tissue plasminogen activator , its inhibitor ( PAI 1 ) and the von Willebrand factor were unchanged . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The regional chromosomal location of the human gene for plasminogen activator inhibitor type 1 ( PAI 1 ) was determined by three independent methods of gene mapping . ^^^ The PAI 1 RFLP may prove to be valuable in ordering genetic markers in the CF linkage group and may also be valuable in genetic analysis of plasminogen activation related diseases , such as certain thromboembolic disorders and cancer . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator in normal subjects after exercise and venous occlusion : t PA circulates as complexes with C 1 inhibitor and PAI 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The plasminogen activator inhibitor 1 ( PAI 1 ) synthesized and released by cultured bovine aortic endothelial cells is present in conditioned medium in a latent form that can be activated by guanidine hydrochloride [ Hekman , C . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Both the urokinase type and tissue type plasminogen activator can convert their approximately 54 kDa type 1 inhibitor ( PAI 1 ) to an inactive form with a lower apparent molecular mass . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Full length cDNA for plasminogen activator inhibitor ( PAI 1 ) was isolated from a human umbilical vein endothelial cell ( HUVEC ) lambda gt 11 cDNA library . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We studied the immunocytochemical localization of urokinase type plasminogen activator ( u PA ) and the type 1 plasminogen activator inhibitor ( PAI 1 ) in human fibroblasts and sarcoma cells , using both polyclonal and monoclonal antibodies . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have studied the mechanism of a transforming growth factor beta ( TGF beta ) stimulated production of type 1 plasminogen activator inhibitor ( PAI 1 ) in WI 38 human lung fibroblasts . ^^^ Urokinase type ( u PA ) and tissue type ( t PA ) plasminogen activators are decreased in the culture media of TGF beta treated cells concomitantly with the increase in PAI 1 accumulation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The extracellular matrix ( ECM ) of cultured bovine aortic endothelial cells ( BAEs ) was analyzed by immunoblotting and reverse fibrin autography and shown to contain type 1 plasminogen activator inhibitor ( PAI 1 ) . ^^^ Most PAI 1 in the ECM formed complexes with exogenously added tissue type plasminogen activator ( tPA ) , demonstrating that this PAI 1 was functionally active . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Dexamethasone increases type 1 plasminogen activator inhibitor ( PAI 1 ) activity released from the human fibrosarcoma cell line HT 1080 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
TGF beta induced the synthesis and secretion of the Mr 47 , 000 endothelial type plasminogen activator inhibitor ( PAI 1 ) as shown by reverse zymography , immunblotting , and immunoprecipitation analyses . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Activation of human endothelial cell type plasminogen activator inhibitor ( PAI 1 ) by negatively charged phospholipids . ^^^ The endothelial cell type plasminogen activator inhibitor ( PAI 1 ) may exist in an inactive , latent form that can be converted into an active form upon treatment of the protein with denaturants , such as sodium dodecyl sulfate , guanidine HCl , or urea . ^^^ In the presence of PS vesicles , PAI 1 inhibited tissue type plasminogen activator 50 fold more effectively than in the absence of phospholipids , whereas sodium dodecyl sulfate enhanced PAI 1 activity by 25 fold . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Association of a plasminogen activator inhibitor ( PAI 1 ) with the growth substratum and membrane of human endothelial cells . ^^^ We have studied the distribution of the plasminogen activator inhibitor type 1 ( PAI 1 ) in cultures of confluent human umbilical vein endothelial cells . ^^^ Incubation of isolated metabolically labeled substratum with tissue plasminogen activator ( tPA ) resulted in the appearance and release of an immunologically related inactive 44 , 000 Mr form as well as the tPA PAI 1 complex ( 110 , 000 Mr ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The aim of the present work was to clarify to what extent plasminogen activator inhibitor 1 ( PAI 1 ) and plasminogen activator inhibitor 2 ( PAI 2 ) contribute to the increase in plasma inhibition of tissue type plasminogen activator ( t PA ) observed during pregnancy . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
One important protease inhibitor whose production is affected rapidly by TGF beta is the type 1 plasminogen activator inhibitor ( PAI 1 ) . ^^^ These results , together with previous data , suggest that PAI 1 and plasminogen activators may be regulated oppositely by TGF beta . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Four fibrinolytic parameters , i . e . fibrinolytic activity at rest ( FAr ) , fibrinolytic response after 10 minutes of venous occlusion ( delta FA 10 ' ) , and resting antigenic levels of the plasmatic inhibitor of the plasminogen activators ( PAI 1 ) and of urokinase ( u PA ) , showed significant differences between the two study groups . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Constitutive gene expression of four components of plasminogen activating enzyme system , urinary and tissue type plasminogen activator ( u PA and t PA ) , plasminogen activator inhibitor 1 ( PAI 1 ) and PAI 2 in HT 1080 human fibrosarcoma cells , was modulated by the synthetic glucocorticoid dexamethasone ( Dex , 10 ( 7 ) M ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
During a survey of four month ' s duration the following parameters were determined in 43 healthy blood donors ( 22 males , 21 females ; mean age 29 years / 20 49 / ) : plasminogen activity , plasminogen concentration , alpha 2 antiplasmin ( alpha 2 AP ) activity , alpha 2 AP concentration , tissue type plasminogen activator ( t PA ) activity , t PA concentration , plasminogen activator inhibitor 1 ( PAI 1 ) activity , AT 3 activity , AT 3 concentration and heparin cofactor 2 ( HC 2 ) activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Incubation of HTC rat hepatoma cells with the synthetic glucocorticoid dexamethasone rapidly inhibits tissue type plasminogen activator activity by inducing a specific plasminogen activator inhibitor ( PAI 1 ) . ^^^ Purified PAI 1 rapidly inhibited and formed complexes with both tissue type and urokinase type plasminogen activators . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Functional and immunologic assays indicated that both cytokines decreased HUVEC tissue type plasminogen activator ( tPA ) and increased type 1 plasminogen activator inhibitor ( PAI 1 ) in a dose and time dependent manner . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The latter is due in part to increased levels of the 48 kDa plasminogen activator inhibitor ( PAI 1 ) present in the plasma of non pregnant individuals . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The regulatory region of the human plasminogen activator inhibitor type 1 ( PAI 1 ) gene . ^^^ The human gene for plasminogen activator inhibitor type 1 ( PAI 1 ) has been isolated and its promoter region characterized . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Using a solid phase radioimmunoassay , we observed that antibodies to recombinant tissue type plasminogen activator ( rt PA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) bound to the surface of cultured human umbilical vein endothelial cells ( HUVEC ) . ^^^ When added at low concentrations ( less than 5 nM ) , rt PA bound with high affinity mainly via the catalytic site , forming a sodium dodecyl sulfate stable 105 kDa complex which dissociates from the cell surface over time and which could be immunoprecipitated by a monoclonal antibody to PAI 1 . rt PA bound to this high affinity site retained less than 5 % of its expected plasminogen activator activity . ^^^ These studies suggest that tissue type plasminogen activator and PAI 1 are expressed on the surface of cultured HUVEC . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have determined the nucleotide sequence of the human plasminogen activator inhibitor 1 ( PAI 1 ) gene and significant stretches of DNA which extend into its 5 ' and 3 ' flanking DNA regions ; a total sequence of 15 , 867 base pairs ( bp ) is presented . ^^^ A major finding is the identification of a large region of shared nucleotides ( comprising of about 520 bp ) between the 5 ' flanking DNAs of PAI 1 and tissue type plasminogen activator genes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Daytime fluctuations in blood of tissue type plasminogen activator ( t PA ) and its fast acting inhibitor ( PAI 1 ) . ^^^ Also , activity and antigen of plasminogen activator inhibitor 1 ( PAI 1 ) and antigen of t PA showed fluctuations but with an opposite pattern to that of t PA activity , with highest levels in the morning and lowest ones in the afternoon . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Our knowledge about the components of the fibrinolytic system has greatly increased during the last few years thanks to the cloning of the cDNA of the two plasminogen activators t PA and u PA , of the two plasminogen activator inhibitors PAI 1 and 2 , and of other profibrinolytic and of inhibitory factors of this system . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Highly purified plasminogen activator inhibitors of type 1 ( PAI 1 ) and type 2 ( PAI 2 ) , low Mr form , were compared with respect to their kinetics of inhibition of tissue type ( t PA ) and urokinase type plasminogen activator ( u PA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is a specific and rapid inhibitor of tissue plasminogen activator ( tPA ) and urokinase . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Incubation of HTC rat hepatoma cells with the synthetic glucocorticoid dexamethasone rapidly inhibits plasminogen activator ( PA ) activity and reveals the presence of a specific PA inhibitor ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
There were positive and independent correlations between tissue plasminogen activator ( tPA ) activity after venous occlusion and HbA1c , and between triglycerides and plasminogen activator inhibitor ( PAI 1 ) and tPA antigen concentrations before and after venous occlusion . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Purified , two chain mutant tPAs , or analogues of tPA , lacking one or several structural domains , along with Bowes melanoma tPA were studied in order to determine their susceptibility to inhibition by plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue plasminogen activator ( tPA ) , plasminogen activator inhibitor type 1 ( PAI 1 ) , alpha 2 antiplasmin ( alpha 2 AP ) and plasminogen are definitely involved in fibrinolysis because : ( 1 ) these components can be assigned a fibrinolytic role in purified systems , i . e . in vitro , and ( 2 ) abnormal structural variants and abnormal levels of these components give rise to bleeding or to thrombosis . ^^^ The humoral regulation involves : ( 1 ) the reaction between tPA and PAI 1 ; ( 2 ) the fibrin stimulated plasminogen activation ; ( 3 ) the reaction between plasmin and alpha 2 AP and ( 4 ) plasmin degradation of fibrin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Reduction in plasminogen activator inhibitor 1 ( PAI 1 ) with omega 3 polyunsaturated fatty acid ( PUFA ) intake . ^^^ Activity of plasminogen activator inhibitor 1 ( PAI 1 ) in human blood correlates with thrombotic tendency and with serum triglyceride concentrations . ^^^ After 4 weeks of Max EPA intake by coronary artery disease patients , serum triglyceride concentrations and PAI 1 levels decreased 43 + / 8 % and 21 + / 5 % , respectively ( both p less than or equal to 0 . 01 ) without any change in tissue plasminogen activator ( TPA ) levels . ^^^ No changes were noted at 1 week of Max EPA intake in normal subjects , but at 3 weeks serum triglyceride concentrations and PAI 1 levels decreased 32 + / 13 % and 22 + / 4 % , respectively ( p less than or equal to 0 . 01 ) without any change in tissue plasminogen activator ( TPA ) levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is a member of the serine protease inhibitor super family ( SERPINS ) which is thought to play an integral role in the control of plasminogen activation . ^^^ PAI 1 inhibits both tissue type plasminogen activator and urokinase type plasminogen activator and may therefore be implicated in the control of various physiological processes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
By use of an enzyme linked immunosorbent assay , we have found that phorbol 12 myristate 13 acetate ( PMA ) causes an approximately 10 fold increase in the level of type 1 plasminogen activator inhibitor ( PAI 1 ) accumulated in conditioned medium of the human rhabdomyosarcoma cell line . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The effects of human activated protein C ( APC ) and thrombin on plasminogen activator inhibitor ( PAI 1 ) released from cultured human umbilical endothelial cells , grown in serum free 35S methionine containing medium , were studied in two ways : measurement of PAI 1 activity with an amidolytic assay , and immunoprecipitation of the medium with anti PAI 1 IgG , anti protein C IgG or anti thrombin IgG followed by SDS PAGE and autoradiography . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The plasminogen activator inhibitor from human endothelial cells ( PAI 1 ) exists in two forms in the culture medium : an active form that binds to and inactivates plasminogen activators and a latent form that in its native state has no anti activator activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Changes in PIC , tissue type plasminogen activator , and plasminogen activator inhibitor 1 ( PAI 1 ) in the clinical course of case 1 suggested that fibrinolysis was suppressed by relatively elevated level of PAI 1 around the operation , but thereafter was adversely accelerated by relatively lower levels of PAI 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Changes in plasma tissue plasminogen activator ( t PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) by the interferon treatment for chronic hepatitis C ] . ^^^ To determine the effects of interferon ( IFN ) treatment for chronic hepatitis C on vascular endothelium , we measured the concentrations of tissue plasminogen activator ( t PA ) and its inhibitor ( PAI 1 ) in the plasma from patients before and after IFN treatment for 14 consecutive days . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Two clusters of haemostatic factors could be distinguished in which each variable was correlated ( P < 0 . 001 ) to every other variable : ( a ) Eight fibrinolysis assays including t PA , PAI 1 and euglobulin clot lysis time ( ECLT ) , for which PAI 1 appeared to be the dominating factor ; ( b ) antithrombin 3 , protein C , alpha 2 antiplasmin and plasminogen , the interdependence of which has no obvious explanation . ( 2 ) . ^^^ C reactive protein , an acute phase reactant , was positively correlated ( P < 0 . 001 ) with fibrinogen , factor VIIIc , von Willebrand factor , the fibrinolysis assays t PA , PAI 1 , ECLT and plasminogen . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The relations between glucose , insulin and insulin propeptides , in the fasting state , and after an oral glucose load , and haemostatic function were examined in 62 consecutive non diabetic men with myocardial infarction before the age of 45 and in 41 age matched healthy men . `` True ' ' hyperinsulinaemia , raised plasma concentrations of insulin propeptides , dyslipoproteinaemia , elevated plasma levels of fibrinogen , factor 7 antigen ( VIIag ) and plasminogen activator inhibitor 1 ( PAI 1 ) activity , and lower antithrombin activity ( p < 0 . 05 0 . 001 ) characterized the patients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We therefore evaluated the mRNA levels for urokinase type plasminogen activator ( u PA ) , urokinase type plasminogen activator receptor ( u PAR ) , and plasminogen activator inhibitor type 1 ( PAI 1 ) by using Northern blot analysis and in situ hybridization in four cases of GCT and spindle shaped mononuclear cells at the 35th passage from a GCT . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS Plasma Lp ( a ) was measured by enzyme linked immunosorbent assay , lipids and lipoproteins by enzymatic methods , and apolipoproteins A 1 and B , fibrinogen ( turbidimetric method ) , tissue plasminogen activator ( t PA ) , plasminogen activator inhibitor 1 ( PAI 1 ) , and D dimer levels by enzyme immunoassay . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) , an important risk factor for thrombotic diseases , is a member of the superfamily of serine proteinase inhibitors . ^^^ Both neoantigenic epitopes were also exposed after complex formation between PAI 1 and either urokinase type plasminogen activator , plasmin or thrombin as well as after cleavage of the reactive site loop of non inhibitory substrate type PAI 1 variants . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The serpin plasminogen activator inhibitor 1 ( PAI 1 ) spontaneously adopts an inactive or latent conformation by inserting the N terminal part of the reactive center loop as strand 4 into the major beta sheet ( sheet A ) . ^^^ P 14 P7 in the reactive loop of PAI 1 ) formed stable complexes with PAI 1 and converted the inhibitor to a substrate for tissue type plasminogen activator . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
PmC were relevant in monitoring the fibrinolytic state in blood . 2 ) Both tissue plasminogen activator ( t PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) levels were sustained continuously in the elevated levels in the blood during both UK administration and pulse therapy . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We recently localized the high affinity binding site for activated type 1 plasminogen activator inhibitor ( PAI 1 ) to the somatomedin B domain ( i . e . amino acid ( aa ) 1 51 ) of vitronectin ( Vn ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Increased concentrations of plasminogen activator inhibitor type 1 ( PAI 1 ) in plasma are associated with impaired fibrinolysis and venous and arterial thrombo embolic disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
It has been posited that the GPI anchor facilitates clearance of uPAR bound complexes between two chain urokinase ( tcuPA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) by the alpha 2 macroglobulin receptor ( alpha 2MR ) which permits re expression of unoccupied uPA receptors on the cell surface . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Prothrombin time , activated partial thromboplastin time , fibrinogen , antithrombin 3 , tissue type plasminogen activator ( tPA ) activity , plasminogen activator inhibitor type 1 ( PAI 1 ) activity , and platelet aggregation were measured and compared to those in an age matched control group ( C , n = 7 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor type 1 ( PAI 1 ) is the rapid physiologic inhibitor of tissue type plasminogen activator and urokinase type plasminogen activator ( uPA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Chem . 268 , 13691 13696 ) , ligand blotting was used to localize the binding sites for urokinase type plasminogen activator plasminogen activator inhibitor 1 ( PAI 1 ) complexes and for alpha 1 macroglobulin to a proteolytic fragment of LRP containing the second cluster of complement type cysteine rich repeats . ^^^ A minireceptor containing the cluster of eight complement type cysteine rich repeats followed by four epidermal growth factor precursor homologous domains binds and internalizes 125I labeled plasminogen activator PAI 1 complexes . ^^^ It also mediates the cellular uptake of the uncomplexed protease tissue type plasminogen activator ( tPA ) , suggesting that the tPA and PAI 1 binding sites on LRP are in close vicinity and might promote cooperative binding of tPA PAI 1 complexes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Urokinase plasminogen activator ( uPA ) activity has previously been shown to play a role in migration of cells into basement membranes , and it has been proposed that uPAR also is involved in this process . uPA is known to be internalized and degraded after complex formation with the inhibitor PAI 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In this study , we report that human recombinant HGF stimulates expression of plasminogen activator inhibitor type 1 ( PAI 1 ) and tissue factor ( TF ) in the human hepatoma cell line HepG 2 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have used this method to identify the epitope recognized by a mAb , CB5B10 , raised against plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Because of the potential importance of plasmin generation in these processes , we evaluated the effect of elevated glucose concentrations on expression of plasminogen activator inhibitor 1 ( PAI 1 ) , tissue plasminogen activator ( tPA ) , and urokinase ( uPA ) in cultured bovine brain endothelial cells ( BBEC ) versus cultured bovine aortic endothelial cells ( BAEC ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Assays for urokinase plasminogen activator type ( uPA ) , plasminogen activator inhibitor 1 ( PAI 1 ) and the urokinase receptor ( uPAR ) were conducted . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Active PAI 1 ( plasminogen activator inhibitor 1 ) is bound to vitronectin in plasma and in the extracellular matrix . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In an inflammatory response , endothelial cells are activated to up regulate a number of genes , including E selectin ( ELAM 1 ) , VCAM 1 , ICAM 1 , interleukin ( IL ) 1 , IL 8 and plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Determination of the vitronectin binding site on plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^ Vitronectin is the carrier protein of plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tat was shown to activate human CNS derived endothelial cells ( CNS EC ) by the increase in the expression of E selectin , the synthesis of IL 6 , and the secretion of plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Such a transconformation may be used for targeting the PKA phosphorylation to vitronectin molecules bound to GAGs , for example in the extracellular matrix or on cell surfaces ; ( f ) From the biochemical point of view ( Km values and physiological concentrations ) the phosphorylation of vitronectin can take place at the locus of a hemostatic event ; ( g ) The phosphorylation of Ser 378 in vitronectin alters its function , since it significantly reduces its ability to bind the inhibitor 1 of plasminogen activator ( s ) ( PAI 1 ) . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
For each sample the plasma levels of betathromboglobulin ( BTG ) fibrinopeptide A ( FPA ) , tissue plasminogen activator ( tPA ) , plasminogen activator inhibitor ( PAI 1 ) and D dimer ( D D ) ( ELISA , methods , kits Boehringer ) were measured . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Comparable reductions in overall protein synthesis and the synthesis of E selectin and plasminogen activator inhibitor 1 ( PAI 1 ) were observed . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Platelet function was further studied by measuring the release of carbon 14 labeled serotonin , beta thromboglobulin , plasminogen activator inhibitor 1 ( PAI 1 ) and the generation of thromboxane ( TxB 2 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The LDL receptor related protein is a multifunctional endocytotic receptor that clear apo E and / or lipoprotein lipase enriched lipoproteins , proteases such as alpha 2 macroglobulin plasminogen and activator inhibitor 1 ( PAI 1 ) , Pseudomonas exotoxin A and probably vitellogenin from blood circulation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A particular emphasis was placed on fibrinogen , factor 7 activity , von Willebrand factor ( vWF ) , plasminogen activator inhibitor 1 ( PAI 1 ) activity , anticoagulant proteins C and S , thrombin antithrombin complex and D dimer . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Patients ' plasma levels of ATM ( thrombin induced modified antithrombin 3 ) , FbDP ( fibrin degradation products , D Dimers ) , t PA ( tissue type plasminogen activator ) and PAI 1 ( plasminogen activator inhibitor type 1 ) were measured at regular intervals . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We used an immunohistochemical assay with an antigen retrieval technique to study plasminogen activator inhibitor type 1 ( PAI 1 ) expression in paraffin embedded breast tissue samples at different stages of malignant transformation . ^^^ PAI 1 production by invasive breast cancers could reflect a general upregulation of the plasminogen activation system in proliferating cancer cells , as suggested by the finding that normal mammary epithelium cultures expressed PAI 1 in all cases examined . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The low density lipoprotein receptor related protein / alpha 2 macroglobulin receptor ( LRP ) mediates endocytosis of a number of structurally unrelated ligands , including complexes of plasminogen activator inhibitor type 1 ( PAI 1 ) and tissue type plasminogen activator ( t PA ) or urokinase plasminogen activator ( u PA ) , free t PA , single chain urokinase ( pro u PA ) , alpha 2 macroglobulin protease complexes , and lipoprotein lipase . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Recently , relative increases in the amounts of urokinase type plasminogen activator ( uPA ) and plasminogen activator inhibitor 1 ( PAI 1 ) in tumor samples have been correlated with poorer , pathological grade , shorter disease free interval , and shorter survival . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In contrast , steady state expression of endothelin 1 and plasminogen activator inhibitor 1 ( PAI 1 ) mRNA was upregulated by TNF alpha . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Isolated Sertoli cells of mouse and rat testes have been shown to secrete plasminogen activator ( PA ) and a plasminogen activator inhibitor type 1 ( PAI 1 ) in culture . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Northern analysis of poly A+RNA prepared from cultured human mesangial cells revealed mRNA for tissue type plasminogen activator ( tPA ) , urokinase type plasminogen activator ( uPA ) , plasminogen activator inhibitor 1 ( PAI 1 ) , and uPA receptor ( uPAR ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Effect of dextran on plasma tissue plasminogen activator ( t PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) during surgery . ^^^ We decided to explore the effect of dextran on plasma tissue plasminogen activator ( t PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) during surgical trauma . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Thrombomodulin activity of endothelial cells was decreased , and plasminogen activator inhibitor 1 ( PAI 1 ) and tumor necrosis factor ( TNF ) alpha in the supernatant were increased when leukocyte adhesion occurred after exposure to nonionic contrast agents . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Although procoagulant molecules ( e . g . , tissue factor [ TF ] ) and fibrinolytic components ( e . g . , urokinase [ u PA ] and type 1 plasminogen activator inhibitor [ PAI 1 ] ) have been detected in alveolar fluid from injured lungs , the origin of these molecules remains unknown . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Recent studies have shown that elevated levels of urokinase plasminogen activator ( uPA ) and plasminogen activator inhibitor 1 ( PAI 1 ) in breast cancer correlate with an increased risk of a reduced relapse free survival time and shortened overall survival times . ^^^ The fact that plasminogen activators are indispensable for tube formation of microvascular cells and that they may induce angiogenesis in vitro strongly suggests a role for uPA and PAI 1 in tumour neovascularisation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Patients with elevated plasminogen activator inhibitor 1 ( PAI 1 ) levels or decreased release of tissue plasminogen activator ( t PA ) antigen were given information and advice about improved diet , increased physical activity , weight loss and / or cessation of smoking . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is unique among the serine proteinase inhibitors ( serpins ) in that it can adopt at least three different conformations ( active , substrate and latent ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The distributions of urokinase and tissue plasminogen activators ( uPA , tPA ) , uPA receptor ( uPAR ) , and plasminogen activator inhibitors ( PAI 1 , PAI 2 ) were studied immunohistochemically in two subsets of colorectal adenocarcinomas with low and high aggressiveness , respectively : nine Dukes ' stage A tumors with additional other good prognostic markers and 13 Duke ' s stage C tumors with also other poor prognostic markers ( referred to as Dukes ' stage A and Dukes ' stage C tumors ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have followed the synthesis and secretion of urokinase type plasminogen activator ( u PA ) and its inhibitor , PAI 1 , and matrix metalloproteinases ( MMPs ) and tissue inhibitor of metalloproteinases ( TIMP 1 ) during differentiation of a human osteoblastic cell line , HOS TE 85 , and the effect of TNF alpha on this process . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Urokinase type plasminogen activator and its inhibitor PAI 1 : predictors of poor response to tamoxifen therapy in recurrent breast cancer . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
At two to six hours stimulated expression of the genes encoding plasminogen activator inhibitor ( PAI 1 ) and platelet derived growth factor ( PDGF ) A chain was detected , but constitutive expression of urokinase type plasminogen activator ( u PA ) was not altered . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To evaluate the role of mesothelial cells ( MC ) in the high peritoneal fibrin turnover we investigated the expression of tissue type plasminogen activator ( t PA ) , urokinase type plasminogen activator ( u PA ) , plasminogen activator inhibitor type 1 ( PAI 1 ) , and tissue factor in cultured human peritoneal MC under basal conditions and after exposure to tumour necrosis factor alpha ( TNF alpha ) , interleukin 1 alpha ( IL 1 alpha ) , or bacterial lipopolysaccharide ( LPS ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The following parameters were evaluated at the time 0 and after 2 , 4 , 6 , 8 , 10 and 12 hours from each administration : tissue plasminogen activator ( t PA ) and its inhibitor PAI 1 , euglobulin lysis time , plasminogen and alfa 2 antiplasmin as indexes of the fibrinolytic system ; aPTT , TT , fibrinogen as indexes of the hemostatic coagulative system . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The following parameters were evaluated : tissue plasminogen activator ( t PA ) , plasminogen activator inhibitor ( PAI 1 ) , euglobulin lysis time ( ELT ) , plasminogen , alpha 2 antiplasmin , prothrombin time ( PT ) , activated partial thromboplastin time ( aPTT ) , thrombin clotting time ( TCT ) , and fibrinogen . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We investigated the relationship between fasting insulin level and various hemostatic factors , including fibrinolytic factors ( active plasminogen activator inhibitor 1 ( PAI 1 ) , tissue type plasminogen activator ( tPA ) PAI 1 complex , plasmin alpha 2 plasmin inhibitor ( PIC ) , and D dimer ) , coagulation factors ( activated factor 7 , factor 7 coagulant activity and antigen , factor 8 , factor 10 , and fibrinogen ) , coagulation inhibitors ( antithrombin 3 , heparin cofactor 2 , and protein C ) , and an acute phase marker ( sialic acid ) in 102 healthy individuals aged > or = 75 years ( 46 men and 56 women ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor type 1 ( PAI 1 ) is an important physiological inhibitor of the plasminogen activator system . ^^^ Complex formation with target proteases , tissue type plasminogen activator ( tPA ) and urokinase type plasminogen activator ( uPA ) , caused decreased orientational freedom of BDYIA in the P 3 position , while the orientational freedom of BDYIA in position P 1 ' increased to a level similar to that of BDYIA in reactive center cleaved PAI 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is a primary endogenous inhibitor of tissue type plasminogen activator ( t PA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
An enzyme immunoassay for the simultaneous determination of active type 1 plasminogen activator inhibitor ( PAI 1 ) , and t PA / PAI 1 complexes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The activity and immunoreactivity of tissue type plasminogen activator ( tPA ) as a protease for angiogenesis and the immunoreactivity of its inhibitor , plasminogen activator inhibitor 1 ( PAI 1 ) , were measured in conditioned medium of HUVEC stimulated for 24 h with saponin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Serial changes in plasma plasminogen activator inhibitor 1 ( PAI 1 ) , plasma tissue plasminogen activator ( t PA ) antigen and serum lipoprotein ( a ) levels were compared between the two groups . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In order to determine whether the T cell lymphokines interleukin 4 ( IL 4 ) and gamma interferon ( gamma IFN ) affect SMC fibrinolysis and migration , we examined the effects of human recombinant IL 4 and gamma IFN on human aortic SMC tissue type plasminogen activator ( TPA ) , urokinase type plasminogen activator ( UPA ) , and plasminogen activator inhibitor type 1 ( PAI 1 ) antigen production , as determined by enzyme linked immunosorbent assays . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS AND RESULTS : Experimental measurements of cardiac output , heart rate , tissue plasminogen activator ( TPA ) , urokinase plasminogen activator ( UPA ) , plasminogen activator inhibitor ( PAI 1 ) , C 1 inhibitor , and TPA / C1 inhibitor complex during the infusions and exercise were used to develop a comprehensive fluid phase model of the circulatory regulation of fibrinolysis . alpha and beta adrenergic agonists increased TPA and UPA in plasma by different mechanisms : Phenylephrine decreased hepatic blood flow and thus clearance while isoproterenol stimulated increased secretion of TPA and UPA . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : The thrombolytic properties of a new variant of tissue plasminogen activator ( TPA ) ( T103N , N117Q , KHRR 296 299 AAAA , or TNK TPA ) with longer plasma half life , greater fibrin specificity , and increased resistance to inhibition by plasminogen activator inhibitor ( PAI 1 ) were investigated in a rabbit thrombosed carotid artery model . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE To compare platelet plasminogen activator inhibitor 1 ( PAI 1 ) release in type 2 diabetic patients and healthy control subjects . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma levels of tissue type plasminogen activator ( t PA ) antigen and activity and plasminogen activator inhibitor 1 ( PAI 1 ) antigen were determined at rest and in response to a venous occlusion test . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The presence of mRNA for the uPA receptor ( uPAR ) has been demonstrated in these cells and steady state levels shown to be greatly enhanced , the response being rapid and sustained for at least 24 hours . mRNA for plasminogen activator inhibitor 1 ( PAI 1 ) was modulated in a biphasic manner , with inhibition of the constitutive level apparent at 4 hours of treatment and stimulation apparent at 12 hours and longer , while PAI 1 protein , measured by an ELISA assay for rat PAI 1 , was diminished over this period . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Message levels of urokinase type plasminogen activator ( u PA ) and its inhibitor ( PAI 1 ) and heat shock protein ( HSP ) 70 are markedly raised 4 8 hours after wounding . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The type 1 inhibitor of plasminogen activator ( PAI 1 ) regulates pericellular proteolytic activity functioning , thereby to control matrix integrity , cell growth , and morphology . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Addition of anti TGF beta 1 antibodies , plasminogen activator inhibitor 1 ( PAI 1 ) , or the thrombin inhibitory combination of heparin and anti thrombin 3 ( AT 3 ) to the cells at the time of scraping blocked about 50 % of the increase in bFGF mRNA ; the effects of these agents were not additive . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Recent studies from this laboratory have demonstrated that angiotensin 2 ( Ang 2 ) stimulates the expression of plasminogen activator inhibitor 1 ( PAI 1 ) in cultured endothelial cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The plasma fibrinolytic system was evaluated by determining activities and total plasma concentrations of both tissue type plasminogen activator before and after venous occlusion , and its inhibitor plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^ PAI 1 antigen tended to parallel PAI 1 activity , and levels of tissue type plasminogen activator antigen and activity tended to be lower in the hypertensives at baseline and after venous occlusion , but not significantly different from those in the normotensives . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue plasminogen activator and PAI 1 expression were not altered by TCDD . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Further work in the field of hemostatic factors has shown that fibrinogen , activated coagulation factor 7 , spontaneous platelet aggregation , and elevated levels of plasminogen activator inhibitor 1 ( PAI 1 ) , are all associated with CAD . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
It has been shown that hyperglycaemia may stimulate plasminogen activator inhibitor 1 ( PAI 1 ) over production in human endothelial cells in culture . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Both uPA and its inhibitor , plasminogen activator inhibitor 1 ( PAI 1 ) , were overexpressed in the HPV 16 transformed cells relative to the parental cell line . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor type 1 ( PAI 1 ) was 18 . 4 + / 3 . 6 IU / ml in OSA patients compared with 8 . 2 + / 1 . 7 IU / ml in controls ( p < 0 . 029 ) during rest , indicating decreased fibrinolytic activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) inhibited PA activity of preformed uPA / uPAR complexes and increased cycling of the receptor from the cell surface . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
On the other hand , the levels of 90K were positively correlated with those of cytosolic estrogen receptor , progesterone receptor , urokinase type plasminogen activator , its inhibitor PAI 1 , cathepsin D and PS 2 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The effect of the proteolytic cleavage of plasminogen activator inhibitor type 1 ( PAI 1 ) by human neutrophil elastase ( HNE ) on fibrinolysis was investigated . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is a member of the serine protease inhibitor ( serpin ) supergene family and a central regulatory protein in the blood coagulation system . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To elucidate the pathophysiology of idiopathic pulmonary fibrosis ( IPF ) , we examined procoagulant ( tissue factor : TF ) , fibrinolytic ( tissue type plasminogen activator : t PA and urokinase type plasminogen activator : u PA ) and antifibrinolytic ( plasminogen activator inhibitor 1 : PAI 1 and PAI 2 ) activities in bronchoalveolar lavage ( BAL ) supernatant fluids and BAL cell lysates obtained from IPF patients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
CHIEF OUTCOME MEASURES : Venous blood assay for endotoxin and plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
As markers of endothelial cell dysfunction , levels of von Willebrand factor ( vWF ) , tissue type plasminogen activator plasminogen activator inhibitor 1 ( TPA PAI 1 ) complex , PAI 1 , and tissue factor pathway inhibitor ( TFPI ) were measured . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Type 1 plasminogen activator inhibitor ( PAI 1 ) is the primary inhibitor plasminogen activator and has been found to be increased in a number of clinical conditions generally defined as prothrombotic . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma was assayed for clotting and fibrinolytic activity by measuring thrombin / antithrombin complexes ( TAT ) , prothrombin fragment 1 + 1 ( F 1 + 2 ) , and D dimers ( D di ) ; markers of the endothelial based fibrinolytic components were assayed by measuring tissue plasminogen activator antigen ( t PA Ag ) and its inhibitor ( PAI 1 ) ; finally , the activity of antithrombin 3 , protein C , and protein S were measured . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Twelve healthy male volunteers , mean age twenty five , range twenty one to thirty years , and 12 healthy middle aged male volunteers mean age fifty eight , range forty four to seventy two years , were tested regarding platelet aggregation induced by adenosine diphosphate and fibrinolytic activity , estimated as euglobulin clot lysis time ( ECLT ) , tissue plasminogen activator ( t PA ) , and the fast acting inhibitor against t PA normally referred to as ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : Plasminogen activator inhibitor type 1 ( PAI 1 ) , the primary physiological inhibitor of endogenous plasminogen activators , has been implicated as a potentiating factor in atherogenesis as well as in coronary thrombosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Urokinase type plasminogen activator ( uPA ) and tissue type plasminogen activator ( tPA ) are produced by osteoblasts , as are the specific inhibitor plasminogen activator inhibitor 1 ( PAI 1 ) and a cellular receptor for uPA . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Holter ST segment recording and pretreatment plasma tissue type plasminogen activator ( t PA ) antigen , plasminogen activator inhibitor 1 ( PAI 1 ) antigen , prothrombin fragment F 1 + 2 and soluble fibrin levels were measured in 57 patients with acute evolving myocardial infarction . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Expression of plasminogen activator inhibitor 1 ( PAI 1 ) during cellular remodeling in proliferative glomerulonephritis in the rat . ^^^ Because plasminogen activator inhibitor 1 ( PAI 1 ) has been used as a marker for cell migration as well as matrix accumulation , we were interested in examining the temporal and spatial expression and cellular sources of PAI 1 mRNA and translated protein over the course of HSV induced proliferative glomerulonephritis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) and tissue inhibitor of metallo proteinases ( TIMP ) 1 mRNA levels were significantly increased at two weeks . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To elucidate further the importance of plasminogen activation in epidermal physiology , studies were conducted using mice transgenic for human plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We studied the effect of leukoregulin on the expression of plasminogen activator inhibitor type 1 ( PAI 1 ) in human orbital and dermal fibroblasts . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Northern analysis and ELISA assays showed that 4 HPR at 10 ( 6 ) M enhances the expression of type 1 plasminogen activator inhibitor ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This study investigated the effect of carbazochrome sodium sulphonate ( AC 17 ) on the accumulation of tissue type plasminogen activator antigen ( t PA : Ag ) and plasminogen activator inhibitor 1 antigen ( PAI 1 : Ag ) in culture medium of human umbilical vein endothelial cells ( HUVEC ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A one step enzyme immunoassay ( EIA ) has been developed for plasminogen activator inhibitor 1 ( PAI 1 ) antigen . ^^^ The assay is based on polyclonal antibodies , which were found to be slightly more reactive with tissue type plasminogen activator ( t PA ) / PAI 1 complexes and latent PAI 1 than with active PAI 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
PAI 1 ) , while there was no or very weak binding of active site blocked u PA ( DFP u PA ) , PAI 1 or u PA type 2 plasminogen activator inhibitor complex . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
By multivariate analysis , FT grafts , preoperative plasminogen activator inhibitor 1 ( PAI 1 ) levels , and GEN were predictive of early graft occlusion ( P < 0 . 05 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is the most important inhibitor of tissue type plasminogen activator ( t PA ) in plasma and plays a major role in the regulation of fibrinolysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To see what effect the inflammatory cytokines tumour necrosis factor ( TNF ) , interleukin 1 ( IL 1 ) , and interleukin 6 ( IL 6 ) had , both alone and in combination , on the production of plasminogen activator inhibitor 1 ( PAI 1 ) by human mesothelial cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Butyrate was found to induce a rapid and transient increase in plasminogen activator inhibitor type 1 ( PAI 1 ) mRNA while concomitantly suppressing the constitutive production of both urokinase type plasminogen activator ( uPA ) and uPA receptor ( uPAR ) mRNA transcripts . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
For comparison , a highly metastatic melanoma cell line ( Queen ' s ) that constitutively expresses high tPA production , was transfected with a cDNA coding for human plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Using type 2 pneumocytes , endocytosis of a previously described gp 330 ligand , urokinase ( uPA ) complexed with plasminogen activator inhibitor 1 ( uPA : PAI 1 ) and two new ligands , PAI 1 and pro uPA , was demonstrated . ^^^ In addition , gp 330 acts in concert with LRP in type 2 pneumocytes to mediate clearance of a variety of proteins involved in plasminogen activation , including uPA : PAI 1 complexes PAI 1 and pro uPA . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We previously demonstrated that cultured human umbilical vein endothelial cells ( HUVECs ) overlaid with a fibrin clot induced a slight increase in tissue type plasminogen activator ( t PA ) secretion and marked reduction in plasminogen activator inhibitor 1 ( PAI 1 ) secretion . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
HMEC 1 is a SV 40T transfected human microvascular endothelial cell line that constitutively expresses RNA transcripts for plasminogen activator inhibitor 1 ( PAI 1 ) , tissue type plasminogen activator ( t PA ) , protein S ( PS ) , von Willebrand factor ( vWF ) , and thrombomodulin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The contributing role of hepatocytes and IL 6 in the acute phase like elevation of plasma type 1 plasminogen activator inhibitor ( PAI 1 ) in vivo is not known . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A series of 8 peptides derived from the amino acid sequence accommodating the plasmin cleavage site in vitronectin were synthesized and used to map its binding site for the type 1 plasminogen activator inhibitor ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have shown that a heptapeptide which resides in the middle part of vitronectin ( VN ) is responsible for binding to plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In these studies we examined the effects of HSV infection on HUVEC plasminogen activator inhibitor type 1 ( PAI 1 ) and tissue plasminogen activator ( t PA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Administration of low doses endotoxin or tumor necrosis factor ( TNF ) in human experimental models for sepsis results in transient activation of both coagulation and fibrinolysis and subsequent inhibition of the fibrinolytic system by plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Analysis of cell free conditioned medium obtained from PKC inhibitor treated cultures by micro enzyme linked immunosorbent assay methodologies using uPA and plasminogen activator inhibitor type 1 ( PAI 1 ) specific monoclonal antibodies indicate that the decrease in uPA activity observed by sodium dodecyl sulfate polyacrylamide gel electrophoresis zymography was a direct result of decreased extracellular uPA antigen and not a consequence of increased PAI 1 antigen . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This decrease in PA activity was found to be mediated by a significant increase in plasminogen activator inhibitor type 1 ( PAI 1 ) production . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Kinetic studies are presented which show that native human vitronectin , but not urea treated vitronectin , accelerates the inactivation of human alpha thrombin by human plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Binding of t PA to SMC at 4 degrees C was rapid , specific , saturable , and inhibitable by antibodies to plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^ Internalization and degradation was mediated by the low density lipoprotein receptor related protein / alpha 2 macroglobulin receptor ( LRP ) in that these processes were inhibited by an anti LRP antibody , recombinant LRP associated protein , urokinase type plasminogen activator PAI 1 complexes , and lactoferrin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
High plasma levels of plasminogen activator inhibitor type 1 ( PAI 1 ) , the principal inhibitor of the fibrinolytic system , have been associated with thrombotic and arterial disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The relative topographical distribution of urokinase type plasminogen activator ( uPA ) , tissue type PA ( tPA ) , PA inhibitor 1 ( PAI 1 ) , PA inhibitor 2 ( PAI 2 ) , plasmin ( ogen ) , alpha 2 antiplasmin , and alpha 2 macroglobulin was studied in lesional epidermis of psoriasis vulgaris , and in normal epidermis , by immunohistochemistry . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
VN stabilizes plasminogen activator inhibitor 1 ( PAI 1 ) with potential binding sites reported at both the somatomedin B and heparin binding domains . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Accumulation of plasminogen activator inhibitor type 1 ( PAI 1 ) in the arterial wall may accelerate atherogenesis by inhibiting fibrinolysis , diminishing proteolysis of extracellular matrix proteins , or modifying migration of vascular smooth muscle cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Previous work has shown that LRP is responsible for mediating the internalization of urinary type plasminogen activator ( uPA ) complexed to plasminogen activator inhibitor type 1 ( PAI 1 ) ( Nykjaer et al . , 1992 ; Herz et al . , 1992 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Prognostic value of urokinase type plasminogen activator and 2 inhibitors PAI 1 and PAI 2 in breast cancer ] . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We investigated immunohistochemically the localization of urokinase type plasminogen activator ( u PA ) , tissue type plasminogen activator ( t PA ) , plasminogen activator inhibitor 1 ( PAI 1 ) , plasmin inhibitor ( PI ) , and transforming growth factor beta ( TGA beta ) in tissue sections to examine the relationships between their localization and local invasiveness , tumor size and cervical lymph node metastasis of head and neck squamous cell carcinomas ( SCCs ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The mean values of plasma protein S , von Willebrand factor ( vWF ) , plasminogen activator inhibitor type 1 ( PAI 1 ) , tissue plasminogen activator ( tPA ) were normal and were not correlated neither with that of plasma TM nor with that of plasma beta TG . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Therefore , we assessed the effects of RU 486 administration on the expression of immunoreactive ( ir ) endometrial stromal cell urokinase type ( uPA ) and tissue type ( tPA ) plasminogen activator and their activities as well as levels of ir type 1 plasminogen activator inhibitor ( PAI 1 ) using a well characterized in vitro model of decidualization . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Assessments made at recruitment , and at 2 and 4 months , included measurement of total ulcer surface area , haematological and biochemical screening , measurement of coagulation times , coagulation factor 8 : C ( FVIII : C ) and von Willebrand factor ( vWF ) , and plasminogen activator inhibitor 1 ( PAI 1 ) levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is the primary inhibitor of the plasminogen activators ( PAs ) , tissue type plasminogen activator ( tPA ) , and urokinase type plasminogen activator ( uPA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
There have been reports of abnormalities in the antigenic levels or activity of endothelium derived haemostatic factors , such as tissue type plasminogen activator ( t PA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) ; however the data from these studies are conflicting . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We recently demonstrated that normal mouse kidney contains very low levels of type 1 plasminogen activator inhibitor ( PAI 1 ) , a potent anti fibrinolytic protein , but that during endotoxemia , large amounts of PAI 1 protein and mRNA are expressed in glomerular and peritubular endothelial cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Recent evidence has shown a correlation between the presence of tumor necrosis and low content of tissue plasminogen activator in brain tumors and significantly higher levels of plasminogen activator inhibitor 1 ( PAI 1 ) in human glioblastomas . ^^^ A negative correlation between PAI 1 and tissue plasminogen activator levels almost reached statistical significance ( P = 0 . 07 ) . ^^^ The results of this study indicate that malignant transformation is associated with a significant increase in PAlI 1 and that PAI 1 may play an integral role in the pathogenesis of tissue necrosis , perhaps via the inhibition of tissue plasminogen activator and the promotion of microthrombosis . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Selectivity of the plasminogen activator inhibitor ( PAI 1 ) for the iso enzyme of guanidinobenzoatase on the surface of colonic carcinoma cells . ^^^ The interaction of plasminogen activator inhibitor ( PAI 1 ) with a cell surface protease , guanidinobenzoatase ( GB ) , has been studied in free solution and on the surface of colonic epithelial cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A model of the reactive form of plasminogen activator inhibitor 1 ( PAI 1 ) has been constructed using molecular graphics and starting from the known crystal structure of latent PAI 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Both the decrease in tissue type plasminogen activator ( t PA ) and the increase in plasminogen activator inhibitor 1 ( PAI 1 ) caused by ischemia reperfusion were also significantly suppressed by EGb 761 treatment . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
D dimer , plasminogen activator inhibitor ( PAI 1 ) activity at rest and after exercise , and tissue plasminogen activator ( t PA ) activity after exercise were measured in venous blood in 88 patients with atherosclerotic lesions of various degrees . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We measured three selected components of the fibrinolytic system in amniotic fluid of 36 parturient women , i . e . the antigen of tissue plasminogen activator ( tPA ) and antigens of plasminogen activator inhibitor of type 1 ( PAI 1 ) and type 2 ( PAI 2 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We examined the localization of urokinase type plasminogen activator ( u PA ) , plasminogen activator inhibitors ( PAI 1 and PAI 2 ) and plasminogen ( plg ) in 26 cases of colon cancer by immunohistochemical staining . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) , the primary inhibitor of tissue type plasminogen activator ( t PA ) and urokinase plasminogen activator , is an important regulator of the blood fibrinolytic system . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The role of the finger domain of tissue type plasminogen activator ( t PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) in initiation and progression of thrombolysis . ^^^ Since plasminogen activator inhibitor 1 ( PAI 1 ) is preferentially retained in the platelet rich heads , we conclude that the inhibitor does not interfere with the initial stage of thrombolysis but exerts its action in later stages , resulting in a reduction of the rate of clot lysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Detection of plasminogen activator inhibitor 1 ( PAI 1 ) mRNA in human megakaryocytes by in situ hybridization . ^^^ Platelets have been described to contain a large proportion of the circulating plasminogen activator inhibitor type 1 ( PAI 1 ) which is released on platelet activation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Both tPA and the tPA B chain were largely protected against inhibition by an excess plasminogen activator type 1 ( PAI 1 ) when bound to EC , whereas the same amount of free tPA was totally inactivated . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma thrombin antithrombin 3 complex ( TAT ) , FDP D dimer , activated protein C ( APC ) protein C inhibitor ( PCI ) complex , and tissue type plasminogen activator ( t PA ) , PA inhibitor 1 ( PAI 1 ) were significantly increased in patients with acute myocardial infarction ( AMI ) at onset . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS AND RESULTS : We determined serially in the patients up to 10 days after admission factor 12 and the beta factor XIIa inhibition , kallikrein like activity , prekallikrein , C 1 esterase inhibitor , kallikrein inhibition , high molecular weight kininogen as indicators of the contact phase and bradykinin generation , thrombin antithrombin 3 ( TAT ) complex as marker of the activated coagulation cascade , fibrinogen , plasminogen , plasminogen activator inhibitor 1 ( PAI 1 ) , tissue type plasminogen activator ( TPA ) , and D dimers as indicators of the fibrinolytic system . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The specific , reversible interaction between plasminogen activator inhibitor 1 ( PAI 1 ) and intact fibrin polymers was studied using both purified components and isolated activated platelets as a source of PAI 1 . ^^^ The second order association rate of PAI 1 R346M with tissue type plasminogen activator is over 10 , 000 fold lower than that of wild type PAI 1 , whereas the ability of the variant to bind to fibrin is unaltered . ^^^ Fibrinolysis , mediated by tissue type plasminogen activator , is inhibited in a dose dependent manner by purified PAI 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The proteolytic activity of uPA is modulated by its cell surface receptor , as well as by plasminogen activator inhibitor type 1 ( PAI 1 ) and , to a lesser degree , by other inhibitors . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The levels of plasminogen activators ( uPA and tPA ) and their inhibitors ( PNI and PAI 1 ) were determined by fibrin zymography , ELISA , amidolytic activity assay , complex formation , and Western blot analysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Methods for measuring antigen and activity of plasminogen activators ( t PA , u PA ) , plasminogen activator inhibitors ( PAI 1 , PAI 2 ) and their complex have been improved in the past few years , but few comparative data are available and they should be standardized . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Urokinase ( u PA ) is expressed in stromal cells and only in tumour cells at invasive foci , urokinase receptor ( u PAR ) in tumour cells , plasminogen activator inhibitor type 1 ( PAI 1 ) in the intratumoral extracellular matrix and plasminogen activator inhibitor type 2 ( PAI 2 ) in tumour cells and stromal cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Since abdominal obesity is associated with impaired fibrinolytic capacity and elevated levels of plasminogen activator inhibitor ( PAI 1 ) and since PAI 1 seems to be related to insulin resistance , we investigated the possible effects of dietary intervention on lipids , fibrinolysis , coagulation , and insulin sensitivity in obese PCOS women . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue plasminogen activator ( tPA ) activity and plasminogen activator inhibitor type 1 ( PAI 1 ) activity were used to study fibrinolysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Synthesis and degradation of connective tissue macromolecules in pachydermoperiostosis ( PDP ) : evidence for altered processing of plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^ TGF beta stimulated , both in PDP cells and normal cells , the synthesis of fibronectin , procollagen and plasminogen activator inhibitor l ( PAI 1 ) , but qualitative differences could not be found . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The effect was specific for PAI 1 because tissue type plasminogen activator ( t PA ) and expression of procoagulant activity were not affected by either lipoprotein . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In this investigation we show that uPAR levels correlate with uPA levels in human breast cancers . uPAR levels , however , do not correlate with other components of the plasminogen activator system such as tissue type plasminogen activator ( t PA ) , PAI 1 or PAI 2 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
High and pathological PAI 1 levels before and after the VO test were consistent with a defective fibrinolytic potential due to the inhibitory effect of PAI 1 on plasminogen activation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Transforming growth factor beta ( TGF beta ) regulates the matrix associated plasminogen activator inhibitor 1 ( PAI 1 ) in glomerular mesangial and epithelial cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The level of constitutive plasminogen activator inhibitor type 1 ( PAI 1 ) expression in cultured human orbital fibroblasts is considerably lower than that found in dermal fibroblasts . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
However , it is unknown whether greater constitutive expression of the tPA gene might increase plasminogen activator inhibitor 1 ( PAI 1 ) secretion , which could negate expected increases in fibrinolytic activity that accompany greater tPA protein production . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the present study the expression of tissue type plasminogen activator ( t PA ) , urokinase plasminogen activator ( u PA ) and plasminogen activator inhibitors 1 and 2 ( PAI 1 and PAI 2 ) antigen in conditioned medium from cultured human umbilical vein ( HUVEC ) and human saphenous vein ( HSVEC ) endothelial cells was investigated under basal conditions and after stimulation with LPS , TNF alpha , interferon gamma ( IFN gamma ) or interleukin 6 ( IL 6 ) alone or in combinations . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Additionally , we have measured the release of urokinase ( uPA ) , tissue plasminogen activator ( tPA ) , plasminogen activator inhibitor 1 ( PAI 1 ) and plasminogen activator inhibitor 2 ( PAI 2 ) into the cell culture media . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To clarify the changes which occur postoperatively in intravascular fibrinolysis , plasma levels of tissue type plasminogen activator ( t PA ) antigen , the total plasminogen activator inhibitor type 1 ( PAI 1 ) antigen , and the t PA PAI 1 complexes were assayed in this study . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
If these more common defects are not found , the rarer defects , including HC 2 , plasminogen , or TPA deficiency , dysfibrinogenemia , elevated PAI 1 , or heterozygous homocystinemia should be looked for . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Euglobulin lysis time ( ELT ) , a global measure of plasma fibrinolytic activity , and the levels of tissue plasminogen activator ( tPA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) were not different before and after hysterectomy . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS AND RESULTS : In 107 consecutive patients undergoing coronary angioplasty , we measured plasma levels of tissue type plasminogen activator ( t PA ) , plasminogen activator inhibitor 1 ( PAI 1 ) , von Willebrand factor , and fibrinogen before and immediately after angioplasty and at a 6 month follow up . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A significant relationship has been described between plasminogen activator inhibitor 1 ( PAI 1 ) and plasma insulin concentrations . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Insulin resistance represents a situation with a high risk of atherothrombosis and is accompanied by increased plasma plasminogen activator inhibitor 1 ( PAI 1 ) levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The aim of the study was to evaluate plasma concentration of fibrinogen , plasma activity of antithrombin 3 ( AT 3 ) and plasma activity of plasminogen activator inhibitor ( PAI 1 ) in insulin dependent diabetic ( IDDM ) patients and the assessment of correlation between them and the parameters of glyco metabolic control comprising glycemia and concentrations of fructosamine and glycated hemoglobin HbA1c . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The liver plays many roles in this regulation , including the synthesis of plasminogen , alpha 2 antiplasmin ( alpha 2 AP ) and plasminogen activator inhibitor 1 ( PAI 1 ) , and the clearance of tissue plasminogen activator ( t PA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In experimental animals and humans , intravenous ( i . v . ) injection of endotoxin induces large increases in circulating plasminogen activator inhibitor type 1 ( PAI 1 ) , a major inhibitor of blood fibrinolysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS AND RESULTS : We studied the association of plasminogen activator inhibitor antigen ( PAI 1 ) , tissue type plasminogen activator antigen ( TPA ) , and D dimer with early atherosclerosis in a cross sectional case control study involving 457 pairs chosen from the biracial cohort of the Atherosclerosis Risk in Communities ( ARIC ) Study . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The effect of heparin on the mesangial plasminogen activating system ( tissue type plasminogen activator , t PA , and plasminogen activator inhibitor type 1 , PAI 1 ) , which is thought to be involved in matrix remodelling , has not been previously reported . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Blood samples were analyzed for tissue plasminogen activator ( TPA ) activity and plasminogen activator inhibitor 1 ( PAI 1 ) activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This TM spike was not correlated with the progressive tissue type plasminogen activator ( t PA ) increase , plasminogen activator inhibitor 1 ( PAI 1 ) , or von Willebrand factor ( vWF ) values . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The cells expressed plasminogen activator inhibitor 1 ( PAI 1 ) , but relatively little PAI 2 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) activity is increased in patients with non insulin dependent diabetes mellitus ( NIDDM ) and may contribute to their excess risk of cardiovascular disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor type 1 ( PAI 1 ) , a major inhibitor of fibrinolysis and another risk factor for atherothrombosis , which is associated with features of the metabolic risk factor syndrome ( Syndrome 10 ) was also followed prospectively . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In contrast , the cellular plasminogen activator inhibitor 1 ( PAI 1 ) mRNA level demonstrated biphasic curves during the 24 h after seeding on Matrigel : the PAI 1 mRNA level was increased eightfold initially at 4 h over that at 0 h , then declined , and again secondarily increased to greater than tenfold at 18 h . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The concentrations of the plasminogen activators u PA and t PA as well as the inhibitor PAI 1 were studied immunohistochemically in 35 osteosarcoma specimens compared to 15 Ewing ' s sarcomas and various other bone lesions . ^^^ The immunoreactivities of plasminogen activators in osteosarcoma specimens were significantly higher than PAI 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Conformational studies on plasminogen activator inhibitor ( PAI 1 ) in active , latent , substrate , and cleaved forms . ^^^ Plasminogen activator inhibitor 1 ( PAI 1 ) , the primary physiological inhibitor of t PA , is an unusual member of the serpin family of serine protease inhibitors , in that it spontaneously converts to a latent form . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Induction of plasminogen activator inhibitor type 1 ( PAI 1 ) by proinsulin and insulin in vivo . ^^^ Fasting hyperinsulinemia appears to be associated with decreased fibrinolytic activity in blood , which results from increased activity of plasminogen activator inhibitor type 1 ( PAI 1 ) , a potential independent risk factor for coronary artery disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The answer would appear to be yes , as patent microalbuminuria between 30 and 300 mg / 24 hours is found , as well as retinopathy and an increase in fibrinogen and PAI 1 plasminogen activator inhibitor . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Three of these cell lines co expressed the plasminogen activator inhibitor PAI 1 in addition to uPA . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Net release or uptake were assessed by arterio venous ( AV ) concentration gradients across the forearm of t PA antigen and t PA activity , and plasminogen activator inhibitor antigen type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The tumor associated protease urokinase type plasminogen activator ( uPA ) and its inhibitor PAI 1 were detected in malignant ovarian cancer tissue extracts . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We determined the contribution of plasminogen activator inhibitor type 1 ( PAI 1 ) , stored in the alpha granules of platelets , to thrombolysis resistance and to reocclusion . ^^^ In combination with a single bolus injection of recombinant tissue type plasminogen activator ( rTPA ; 0 . 25 mg / kg ) , the anti PAI 1 antibody reduced thrombus growth significantly , from 21 . 5 + / 2 . 7 % in the animals treated with rTPA alone to 12 . 2 + / 2 . 6 % in the animals treated with rTPA and the antibody . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor type 1 ( PAI 1 ) is a key determinant of the fibrinolytic capacity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The identity of the cell binding site ( s ) , for the most part , appeared to be distinct from other known APC ligands which are associated with cell membranes or extracellular matrix including phospholipid , thrombomodulin , factor 5 , plasminogen activator inhibitor type 1 ( PAI 1 ) and heparin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Because alterations in plasminogen activator inhibitor type 1 ( PAI 1 ) expression or function may be involved in both fibrin deposition and accumulation of extracellular matrix , we have studied the effects of CR on the expression of PAI 1 in kidneys from female B / W mice fed either ad libitum or on a 40 % CR diet . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In addition , such a relation was found for plasminogen activator inhibitor types 1 ( PAI 1 ) and 2 ( PAI 2 ) in SCC 4 monocultures , but not in keratinocyte monocultures . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To investigate structural functional aspects of plasminogen activator inhibitor 1 ( PAI 1 ) we have taken advantage of the lack of cysteines in the PAI 1 molecule and replaced Ser 344 ( P 3 ) and Asn 329 ( P 18 ) with cysteine residues , thereby creating unique attachment sites for extrinsic fluorescent probes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma levels of the vascular endothelial cell markers , thrombomodulin ( TM ) , plasminogen activator inhibitor 1 ( PAI 1 ) , tissue type plasminogen activator ( t PA ) , and von Willebrand factor ( vWF ) were measured in 55 patients on maintenance haemodialysis ( HD ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The factors related to the initiation of fibrinolysis , especially with regard to the tissue type plasminogen activator ( tPA ) and the plasminogen activator inhibitor 1 ( PAI 1 ) , were investigated in 15 patients who underwent hepatic resection , and the findings were compared between those with normal livers and those with diseased livers . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue plasminogen activator ( TPA ) activity and plasminogen activator inhibitor 1 ( PAI 1 ) activity were measured in 15 inactive , 15 regularly active , and 15 highly active men . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the present study , intra individual comparisons were made of the concentrations of t PA , urokinase type plasminogen activator ( u PA ) , PAI 1 , and PAI 2 in GCF from the same sites before and after periodontal treatment in eight healthy male volunteers aged 35 46 yr . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
APC plays an important role in regulating thrombosis and fibrinolysis by inhibiting not only blood coagulation factors Va and VIIIa but also type 1 plasminogen activator inhibitor ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Serum lipids and lipoproteins , and plasma coagulation and fibrinolytic enzymes , including fibrinogen concentrations and plasminogen activator inhibitor 1 ( PAI 1 ) activity were measured at baseline and after 6 week supplementation of either fish or olive oil . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor C 1 ( PAI 1 ) plays a critical role in the regulation of fibrinolysis , serving as the primary inhibitor of tissue type plasminogen activator . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To investigate a possible link between endothelial cell damage and VOD , tissue plasminogen activator ( tPA ) and its inhibitor ( PAI 1 ) were measured in 32 patients as endothelial cell derived parameters of the fibrinolytic system . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue type plasminogen activator ( t PA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) were identified as the primary plasminogen activator and plasminogen activator inhibitor , respectively , in equine blood . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To determine whether unsaturated fatty acids induce changes in the mRNA level of plasminogen activator inhibitor type 1 ( PAI 1 ) , Northern analyses were performed on human umbilical vein endothelial cells ( HUVEC ) and vascular smooth muscle cells that were treated with two common fatty acids . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue plasminogen activator ( tPA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) were quantitated using standard chromogenic activity assays . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Factor 8 activity ( 8 : C ) , von Willebrand factor antigen ( vWF : Ag ) , tissue plasminogen activator antigen ( tPA ) , plasminogen activator inhibitor activity ( PAI 1 ) , antithrombin 3 , protein C and protein S were assayed before and 1 , 3 , 6 , 12 , 18 , and 24 months after BMT . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Our specific aim was to compare three plasminogen activator inhibitor type 1 ( PAI 1 ) antigen ELISA kit assays ( the Biopool AB , Ltd , TintElize PAI 1 Strip Well Format ; the American Diagnostica , Inc . , Imubind 822 / 1 ; and the second generation Imubind 822 / 1S ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS AND RESULTS : We determined levels of plasminogen activator inhibitor ( PAI 1 ) antigen and tissue plasminogen activator ( TPA ) antigen in 1431 subjects from the Framingham Offspring Study . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma levels of beta thromboglobulin ( BTG ) , platelet factor 4 ( PF 4 ) , tissue plasminogen activator ( t PA ) , plasminogen activator inhibitor ( PAI 1 ) and plasminogen were determined in 36 essential hypertensive and 20 age and sex matched control subjects . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In addition , we describe the relationship between vitronectin ( VN ) and plasminogen activator inhibitor 1 ( PAI 1 ) in the self regulating mechanism of TGF beta action for fibrogenesis in acute viral hepatitis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) , specific inhibitor of plasminogen activators ( PA ) , plays an important role in the regulation of fibrinolysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Neither drug had an effect on tissue type plasminogen activator or plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Measurements were made of serum estradiol , and the plasma concentrations of tissue type plasminogen activator ( t PA ) antigen , plasminogen activator inhibitor ( PAI 1 ) antigen , antithrombin 3 ( AT 3 ) and protein C activity , factor 7 ( FVII ) antigen , and fibrinogen . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We measured fibrinogen levels as well as the fibrinolytic parameters tissue type plasminogen activator ( t PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) in plasma samples obtained at basal conditions and after stimulating the fibrinolytic system by venous occlusion ( VO ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The effects of calcium on human foreskin keratinocyte expression of urokinase type ( uPA ) and tissue type ( tPA ) plasminogen activator enzymes and plasminogen activator inhibitor 1 and 2 ( PAI 1 , PAI 2 ) were assessed by Northern analyses . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Thus , uPA bound to monocyte / macrophages and its interactions with plasminogen activator inhibitors types 1 and 2 ( PAI 1 and PAI 2 ) may modify atherogenesis by altering cell associated proteolytic activity , degradation of ECM , and neointimal formation at sites of vascular injury . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To determine whether previously reported abnormalities in fibrinolytic activity and plasma lipoprotein ( a ) levels could reflect obesity rather than diabetes per se , plasma concentrations of tissue type plasminogen activator ( t PA ) , type 1 plasminogen activator inhibitor ( PAI 1 ) , and lipoprotein ( a ) ( Lp ( a ) ) were investigated in sixty four type 2 diabetic patients ( 56 . 1 + / 9 . 5 years ; body mass index , 24 . 6 + / 3 . 3 kg / m2 ) and thirty two control subjects ( 57 . 9 + / 8 . 9 years ; body mass index , 24 . 6 + / 3 . 4 kg / m2 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Binding parameters [ association rate ( kass ) and dissociation rate ( kdiss ) constants , and affinity constants ( KA = kass / kdiss ) ] for the interaction between urokinase type plasminogen activator ( u PA ) and its substrate plasminogen , its inhibitor plasminogen activator inhibitor 1 ( PAI 1 ) and its receptor ( u PAR ) , were determined by real time biospecific interaction analysis ( BIA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The alpha 2 macroglobulin receptor / low density lipoprotein receptor related protein ( alpha 2MR / LRP ) binds several ligands , including complex between the two chain urokinase type plasminogen activator ( uPA ) and type 1 plasminogen activator inhibitor ( PAI 1 ) , and the single chain zymogen pro urokinase ( pro uPA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Analysis by electrophoresis on SDS PAGE and autoradiography of the cell associated radioactivity and of the intracellular content showed that active u PA and u PA complexed to plasminogen activator inhibitor type 1 ( PAI 1 ) were bound to the cell surface , but only u PA / PAI 1 complexes were internalized and degraded . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Conversely , plasminogen activator inhibitor 1 ( PAI 1 ) levels were slightly higher in group 2 than in group 1 patients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Urokinase plasminogen activator ( uPA ) and its type 1 inhibitor ( PAI 1 ) : regulators of proteolysis during cancer invasion and prognostic parameters in breast cancer . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A positive family history for ischemic complications of atherosclerosis was more common in subjects with a history of stroke than in those without ; moreover , plasma levels of plasminogen activator inhibitor 1 ( PAI 1 ) and tissue type plasminogen activator ( TPA ) were higher in patients with documented previous events . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue plasminogen activator ( TPA ) and plasminogen activator inhibitor 1 ( PAI 1 ) activity were measured before and after exercise . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
TGF alpha enhanced the expression of the tissue type plasminogen activator ( t PA ) gene , whereas TGF beta increased the expression of the PA inhibitor 1 ( PAI 1 ) gene and inhibited that of the t PA gene . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Regulation of plasminogen activator inhibitor 1 ( PAI 1 ) expression by 1 , 25 dihydroxyvitamin D 3 in normal and malignant rat osteoblasts . ^^^ In rat calvarial osteoblast like cells and in clonal osteogenic sarcoma cells ( UMR 106 01 ) , 1 , 25 dihydroxyvitamin D 3 ( 1 , 25 ( OH ) 2D3 ) enhanced plasminogen activator ( PA ) activity and decreased PA inhibitor 1 ( PAI 1 ) production over the same concentration range . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This review presents the structural determinants on the t PA molecule that mediate clearance via these two pathways , gives an overview of the structure of the LRP / alpha 2 MR and discusses the role of plasminogen activator inhibitor type 1 ( PAI 1 ) in the hepatic clearance of t PA . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The plasminogen activator inhibitor PAI 1 is markedly elevated in vivo and in vitro upon exposure to the inflammatory mediators tumor necrosis factor alpha ( TNF alpha ) , interleukin 1 ( IL 1 ) , and bacterial lipopolysaccharide . ^^^ In contrast to TNF alpha induced PAI 1 production , the transcription and synthesis of urokinase type plasminogen activator ( u PA ) was not inhibited by genistein . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Separation of active and inactive forms of recombinant human plasminogen activator inhibitor type 1 ( PAI 1 ) expressed in Chinese hamster ovary cells : comparison with native human PAI 1 . ^^^ Human plasminogen activator inhibitor type 1 , PAI 1 , was expressed in Chinese hamster ovary cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Samples were assayed for coagulation factors ( fibrinopeptide A , antithrombin 3 , protein C ) , fibrinolytic factors [ tissue type plasminogen activator ( t PA ) , alpha 2 antiplasmin , plasminogen activator inhibitor ( PAI 1 ) ] and markers of platelet activation ( platelet factor 4 , beta thromboglobulin ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE To compare platelet plasminogen activator inhibitor 1 ( PAI 1 ) concentration in type 2 diabetic patients and healthy control subjects . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Variables determined were tissue type plasminogen activator ( t PA ) and the plasminogen activator inhibitors type 1 ( PAI 1 ) and type 2 ( PAI 2 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A major hemostatic imbalance was demonstrated with particularly marked reduction in fibrinolytic activity [ drop of antithrombin 3 ( ATIII ) and protein C with an increase of plasminogen activator inhibitor ( PAI 1 ) levels ] which were directly correlated with the severity of the inflammatory state . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Increased plasma activity of plasminogen activator inhibitor 1 ( PAI 1 ) is considered as a risk factor for thrombosis associated with atherosclerosis by reduction of fibrinolysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The action of the mediators over endothelial cells induces an increase in plasminogen activator inhibitor type 1 ( PAI 1 ) levels with inhibition of fibrinolysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The increased levels of fibrinogen , TAT complexes , B beta 15 42 peptide and plasminogen activator inhibitor 1 ( PAI 1 ) in plasma ( p < 0 . 01 ) are consistent with an enhanced fibrin turnover and endothelial perturbation due to a systemic inflammatory state . ^^^ Plasminogen and alpha 2 plasmin inhibitor activity in SF were significantly reduced as compared to the plasma levels ( p < 0 . 01 ) , whereas an increase in PAI 1 activity was found in SF as compared to plasma ( p < 0 . 01 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In this report we examine the effects of mutations at this position , in the serpin , plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^ However , whereas WTPAI 1 forms SDS stable complexes with both plasminogen activators , the mutant PAI 1 was efficiently cleaved as a substrate . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We previously reported that plasminogen activator inhibitor type 1 ( PAI 1 ) mRNA was present at higher steady state levels in prematurely senescent fibroblasts derived from a subject with Werner syndrome ( WS ) compared to early passage ( EP ) fibroblasts from an age matched normal subject ( Murano et al . , 1991 , Mol . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This study was performed to determine whether altered gene expression of plasminogen activator inhibitor type 1 ( PAI 1 ) occurs within the arterial wall after experimentally induced balloon injury . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
There were mutual relations among fibrinolytic parameters such as tissue plasminogen activator ( t PA ) antigens , total plasminogen activator inhibitor 1 ( PAI 1 ) , t PA PAI 1 complex , free PAI 1 , and ECLT . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Hormonal intake was followed by decreased antigen concentrations of tissue plasminogen activator ( t PA ) and plasminogen activator inhibitor ( type 1 [ PAI 1 ] ) , whereas the activities of t PA and PAI 1 were unchanged . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Compared with the plasma values of healthy control children , levels of tissue plasminogen activator ( t PA ) antigen , plasminogen activator inhibitor type 1 ( PAI 1 ) activity , and vWF as well as fibrin ( ogen ) degradation products were significantly elevated in the plasma of HUS patients on admission . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Blood samples were obtained before and after the procedure and were analyzed for fibrinolysis and coagulation indicators such as plasminogen activator type 1 ( PAI 1 ) activity , thrombin antithrombin 3 ( TAT ) complexes , and platelet activation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The conversion of plasminogen into serine protease plasmin with fibrinolytic activity depends on the actual balance between plasminogen activators ( urokinase type ; u PA and tissue type ; t PA ) and their inhibitors ( type 1 and 2 plasminogen activator inhibitors ; PAI 1 and PAI 2 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Compared to the postabsorptive state , plasminogen activator inhibitor ( PAI 1 ) activity and antigen , tissue plasminogen activator ( t PA ) antigen and FFA decreased ( p < 0 . 001 ) after 120 min of euglycemic hyperinsulinemia . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The role of progestationally regulated stromal cell tissue factor and type 1 plasminogen activator inhibitor ( PAI 1 ) in endometrial hemostasis and menstruation . ^^^ This paradoxical relationship was investigated by evaluating endometrial expression of tissue factor ( TF ) , the primary initiator of hemostasis , and plasminogen activator inhibitor 1 ( PAI 1 ) , the primary inhibitor of fibrinolysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Smoking habits correlated with degree of insulin resistance and consequently with various manifestations of the insulin resistance syndrome including levels of insulin , high density lipoprotein cholesterol , triglycerides , and plasminogen activator inhibitor 1 ( PAI 1 ) activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Lipid parameters , Factor 7 ( F 7 ) , fibrinogen , plasminogen activator inhibitor 1 ( PAI 1 ) , and insulin like growth factor 1 ( IGF 1 ) were measured at the same time . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The present study was undertaken to assess the role of tumor associated urokinase type plasminogen activator ( uPA ) and its inhibitor type 1 ( PAI 1 ) as a predictor for early relapse and poor prognosis in patients with stage 2 cervical cancer of the uterus . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Patients with ischaemic heart disease have high levels of plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A significant increase in plasminogen activator inhibitor type 1 ( PAI 1 ) antigen and activity levels was observed in the HR patient group in comparison with the MR and LR groups in the preoperative and early postoperative period . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma D dimers ( one ELISA and two latex assays ) , fibrin monomer , prothrombin fragment 1 + 2 ( F1+2 ) , thrombin antithrombin 3 complex ( TAT ) and the t PA PAI 1 complex were all significantly correlated to the extension of DVT , whilst fibronectin , tissue type plasminogen activator ( t PA ) , single chain urokinase type plasminogen activator ( scru PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) were not . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fibrinolysis is mainly dependent on the activity of tissue plasminogen activator ( tPA ) and its inhibitor plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
High plasma levels of plasminogen activator inhibitor 1 ( PAI 1 ) in polycythemia vera and essential thrombocythemia are associated with thrombosis . ^^^ We studied the hematocrit level , platelet count , use of any antiaggregant drugs , thrombotic or bleeding accidents and plasma levels of antithrombin 3 , protein C , total protein S , free protein S , vWF : Ag ( Von Willebrand ' s factor related antigen ) , thrombin antithrombin complexes , D dimer , fibrinolytic activity , tissue plasminogen activator , plasminogen and PAI 1 in 33 patients ( 19 with ET and 14 with PV ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
When mRNA obtained from RAECs cultured for 16 hours in serum free medium was analysed for the presence of specific messages of tissue type plasminogen activator ( t PA ) , urokinase type plasminogen activator ( u PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) using human probes , weak specific binding could be seen for both t PA and mu PA while the PAI 1 probe gave a strong specific signal at 3 . 4 Kb and a weak signal at 2 . 3 Kb . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
It is demonstrated that 1 ) theca interstitial compartment synthesizes the majority of plasminogen activator inhibitor type 1 ( PAI 1 ) in the ovary before ovulation , and the follicular wall may therefore serve as a specific barrier with the presence of PAI 1 activity to prevent the secretion of tPA into the extrafollicular compartments ; 2 ) granulosa cells secrete only a small amount of ovarian PAI 1 , but synthesize the most of tissue type plasminogen activator tPA involved in the processes leading to ovulation ; 3 ) since only matured cumulus oocyte complexes secrete a large amount of tPA and PAI 1 , both tPA and PAI 1 activity in the conditioned medium may be used as reliable markers for evaluating oocyte quality for in vitro fertilization . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In this study , we used type 1 plasminogen activator inhibitor ( PAI 1 ) , a major inhibitor of the endogenous fibrinolytic system , to determine its efficacy in the suppression of thrombolysis in canines . ^^^ In one group of dogs , activated type 1 plasminogen activator inhibitor ( PAI 1 ) ( 130 micrograms ) was delivered directly into the forming thrombus ; in another , TXA ( 110 mg / kg ) was given intravenously before thrombus formation ; in controls , thrombus was induced without inhibitors . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) plays particularly important role in regulation of homeostasis of fibrinolytic system . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We quantitated urokinase and tissue plasminogen activator ( u PA , t PA ) , plasminogen activator inhibitor 1 and 2 ( PAI 1 , PAI 2 ) , and fibrinolytic activity in peripheral blood ( PB ) , tumour blood ( TB ) , peritoneal / ascitic fluid ( PAF ) and cystic fluid ( CF ) from 104 patients with benign and 36 patients with malignant ovarian tumours , and in peripheral blood from 62 healthy controls . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Increased plasma activity of plasminogen activator inhibitor 1 ( PAI 1 ) in two patients with Klinefelter ' s syndrome complicated by leg ulcers . ^^^ We detected increased activity of plasminogen activator inhibitor 1 ( PAI 1 ) , with only a partial decrease upon venous occlusion . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We investigated the expression and cellular localization of plasminogen activator inhibitor type 1 ( PAI 1 ) in human astrocytoma in vivo . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Cross linked fibrin degradation products ( XL FDP ) , tissue plasminogen activator ( t PA ) antigen , fibrinopeptide A ( FPA ) , and plasminogen activator inhibitor 1 ( PAI 1 ) activity were measured in peripheral blood . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Oral management of a patient with a plasminogen activator inhibitor ( PAI 1 ) deficiency : case report . ^^^ Plasminogen activator inhibitor 1 ( PAI 1 ) deficiency causes a rare bleeding disorder by allowing excessive fibrinolysis to occur . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
PATIENTS AND METHODS : In 22 patients ( 8 men , 14 women , ages 32 to 62 years ) undergoing cardiac catheterization , blood samples were procured before and 15 minutes after the administration of intranasal saline ( n = 8 , controls ) or cocaine , 2 mg / kg ( n = 14 ) , and the plasma concentrations of fibrinogen , plasminogen , and lipoprotein ( a ) , as well as tissue plasminogen activator activity and plasminogen activator inhibitor ( PAI 1 ) activity , were measured . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The impact of long term , heavy exercise on recently established cardiovascular / thromboembolic risk factors of the fibrinolytic system , tissue plasminogen activator ( tPA ) and plasminogen activator inhibitor ( PAI 1 ) in relation to food composition was studied . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In contrast , no change in urokinase type plasminogen activator and plasminogen activator inhibitor 1 ( PAI 1 ) antigen synthesis was seen . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Elevated plasma levels of type 1 plasminogen activator inhibitor ( PAI 1 ) have been implicated in mediating the fibrin deposition and occlusive lesions that occur within the placental vasculature in preeclampsia ( PE ) and intrauterine growth retardation ( IUGR ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To explore alternate hypotheses , we examined the interaction of retinoic acid and IL 1 on endothelial cell ( EC ) function and found that RA directly affects and modifies the effects of IL 1 on EC proliferation , prostacyclin production , and plasminogen activator inhibitor capacity ( PAI 1 ) . ^^^ With respect to plasminogen activator inhibitor capacity , both IL 1 and retinoic acid stimulated EC PAI 1 synthesis , but the individual effects were additive , with RA augmenting the known IL 1 effects on EC PAI 1 production . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
After binding to its receptor ( uPAR ) , active cell surface urokinase ( uPA ) is not internalized while the complex formed by uPA with plasminogen activator inhibitor type 1 ( PAI 1 ) is internalized and degraded . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
On the other hand , endothelial cells also produce plasminogen activator inhibitor 1 ( PAI 1 ) ( 3 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Human colorectal carcinogenesis has been shown previously to be associated with impressive changes in the tissue levels of plasminogen activators and their inhibitors , exemplified by an increase in the urokinase type plasminogen activator ( u PA ) and the inhibitors PAI 1 and PAI 2 , and a decrease in tissue type plasminogen activator ( t PA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Analysis of radiolabeled proteins in the secreted fraction by sodium dodecyl sulfate ( SDS ) polyacrylamide gel electrophoresis ( PAGE ) revealed prominent protein bands at 220 and 49 . 5 kD in both diabetic and nondiabetic cultures that were identified by immunoblot analysis as fibronectin and a mixture of secreted protein acidic and rich in cysteine ( SPARC ) and plasminogen activator inhibitor 1 ( PAI 1 ) , respectively . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
No statistically significant changes in plasminogen activator inhibitor 1 ( PAI 1 ) levels were found . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) , a major regulator of fibrinolysis , is an important component of the acute phase response in humans . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) , the main physiological inhibitor of tissue type plasminogen activator ( t PA ) , may occur in three interconvertible conformations : active , latent , and substrate . ^^^ Incubation of PAI 1 P 12 , PAI 1 P 10 , or PAI 1 P 8 with a 2 fold molar excess of urokinase type plasminogen activator , plasmin , or thrombin also primarily generated a 41 kDa cleavage product ( 62 89 % ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The present study was performed to investigate the acute effects of physiologically induced hyperinsulinemia on plasminogen activator inhibitor 1 ( PAI 1 ) , tissue plasminogen activator ( t PA ) and triglycerides ( TG ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Northern blot analysis demonstrated expression of urokinase type plasminogen activator ( uPA ) , tissue type PA ( tPA ) and PA inhibitor 1 ( PAI 1 ) in some of the above cell lines . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
PURPOSE : Evaluation of the relationship between plasminogen activator inhibitor 1 ( PAI 1 ) and the metastatic potential of primary breast cancer , and to compare the prognostic impact of PAI 1 in multivariate analysis with those of conventional prognostic factors , including steroid hormone receptors , and those of urokinase plasminogen activator ( uPA ) , pS 2 protein ( PS 2 ) , and cathepsin D . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The aims of this study were to determine whether elevated plasminogen activator inhibitor type 1 ( PAI 1 ) activity after myocardial infarction reflects baseline PAI 1 or represents an acute phase response secondary to the infarction , and to determine how tissue plasminogen activator ( t PA ) activity and total t PA antigen levels in healthy control subjects differ from those in patients after myocardial infarction . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS AND RESULTS : To determine if the failure to lyse pulmonary thromboemboli is caused by an abnormality in the endothelial cell ( EC ) associated fibrinolytic system , conditions were established to culture ECs from patient main pulmonary arteries during surgical pulmonary thromboendarterectomies and to analyze the conditioned media for levels of tissue type plasminogen activator ( TPA ) and type 1 plasminogen activator inhibitor ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
It recently has been hypothesized that increased plasma plasminogen activator inhibitor 1 ( PAI 1 ) activity could be a possible link between insulin resistance and coronary heart disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The influence of heparin on the reaction between thrombin and plasminogen activator inhibitor 1 ( PAI 1 ) has been examined . ^^^ Quantitative zymographic analysis of tissue plasminogen activator and PAI 1 activities and chromogenic substrate assay of thrombin activity showed that low affinity heparin stimulated the inactivation of PAI 1 by an equimolar amount of thrombin , but caused only a minimal stimulation of thrombin inhibition . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
PATIENTS AND METHODS : We investigated tissue plasminogen activator ( tPA ) , its main inhibitor ( PAI 1 ) and the natural anticoagulants protein C and S by enzymimmunoassay prospectively in 32 bone marrow transplant recipients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In an attempt to understand the pathogenesis of renal vein thrombosis occurring early after renal transplantation , gene expression of plasminogen activator inhibitor 1 ( PAI 1 ) was investigated by an in situ hybridization technique . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Western blots of Triton extracts incubated with anti tPA antibody demonstrated a major 64 kD protein band , compared to a 70 kD band for standard single chain tPA , plus a minor 118 kD band corresponding to a complex of tPA like PA and plasminogen activator inhibitor ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Cytokine modulation of plasminogen activator inhibitor 1 ( PAI 1 ) production by human articular cartilage and chondrocytes . ^^^ Recombinant human cytokines were examined for their effects on plasminogen activator inhibitor 1 ( PAI 1 ) production by human articular cartilage and chondrocyte monolayer cultures . ^^^ The inhibition of PAI 1 levels by cytokines and reagents which stimulate cartilage resorption ( i . e . , TNF alpha , interleukin 1 alpha , retinoic acid ) and enhancement by cytokines which counter it ( i . e . , TGF beta , bFGF ) further implicate plasminogen activator in the mechanism ( s ) of cartilage degradation in diseases such as arthritis . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is a serpin proteinase inhibitor which regulates fibrinolysis and the proteinase cascade of tumour invasion . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We assayed urokinase plasminogen activator ( uPA ) , tissue type plasminogen activator ( tPA ) , and plasminogen activator inhibitor 1 ( PAI 1 ) in 43 human brain tumors ( predominantly astrocytic gliomas ) and in histologically disease free brain tissue resected with 21 of the tumors . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
If these more common defects are not found , then the rarer defects , including heparin cofactor 2 , plasminogen or tissue plasminogen activator deficiency , dysfibrinogenemia , or elevated PAI 1 should next be sought . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The rates of plasminogen activator inhibitor ( PAI 1 ) , fibrinogen , plasminogen , and alpha 2 antiplasmin , along with the venous occlusion test to determine tissular plasminogen activator ( t PA ) , both functional and antigenic , before and after venous occlusion , were tested in all cases . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Increased plasma levels of plasminogen activator inhibitor 1 ( PAI 1 ) , responsible for reduced fibrinolytic activity , have been shown to be an important risk factor for cardiovascular disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In recent years , epidemiological studies identified some hemostatic parameters whose abnormalities may help predict the risk of ischemic events : fibrinogen [ 14 ] , plasminogen activator inhibitor 1 ( PAI 1 ) [ 3 ] , lipoprotein ( a ) [ 46 ] , anticardiolipin antibodies ( ACA ) and lupus anticoagulant ( LA ) [ 10 ] , leukocyte count [ 34 ] , blood viscosity [ 34 ] . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A positive correlation was also observed between plasma and ascitic fluid plasminogen , anti plasmin and fibrinogen , while a negative correlation was found between plasma and ascitic fluid plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have studied the prognostic value of urokinase type plasminogen activator ( uPA ) , uPA receptor ( uPAR ) , and type 1 plasminogen activator inhibitor ( PAI 1 ) in tumor extracts from 84 patients with squamous cell lung carcinoma and 38 patients with large cell lung carcinoma , measuring each molecule with sandwich enzyme linked immunosorbent assays . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
One of these mechanisms involves internalization of complexes between t PA and its cognate inhibitor plasminogen activator inhibitor type 1 ( PAI 1 ) ; the other mechanism is independent of PAI 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Multiple transforming growth factor beta ( TGF beta ) responsive elements have been identified within the 5 ' flanking region of the plasminogen activator inhibitor type 1 ( PAI 1 ) gene . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue plasminogen activator ( TPA ) antigen , TPA activity , plasminogen activator inhibitor 1 ( PAI 1 ) antigen and PAI 1 activity as fibrinolysis variables , and an angiographic study were performed 2 and 26 weeks after ACBG . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To investigate the potential role of plasminogen activator inhibitor 1 ( PAI 1 ) , which is released from the alpha granules of activated platelets , in thrombolysis resistance , we employed a model ( the `` Chandler loop ' ' ) that mimics the formation of arterial thrombi in vivo and that can be manipulated in terms of rheological parameters and composition of blood cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor type 1 ( PAI 1 ) , the primary physiological inhibitor of tissue type plasminogen activator , is an unusual member of the serine protease inhibitor ( serpin ) superfamily in that it spontaneously converts to a latent form lacking activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In multivariate analysis , VLDL and global coronary atherosclerosis score predicted reinfarction ; plasma plasminogen activator inhibitor 1 ( PAI 1 ) activity and global coronary stenosis score predicted cardiac death ; and VLDL triglyceride levels , global coronary atherosclerosis score and age predicted any major coronary event . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have characterised the urokinase type and the tissue type plasminogen activators ( PA ) and their inhibitor , PAI 1 , secreted from glomerular epithelial and mesangial cells as well as their co cultures and have investigated the effect of transforming growth factor beta 1 ( TGF beta 1 ) on the production of such species . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In HUVEC , the ratio of fibrinolysis antigens was antifibrinolytic , consisting of 55 fold more plasminogen activator inhibitor type 1 ( PAI 1 ) than tissue type plasminogen activator ( tPA ) . ^^^ In contrast , HRMEC produced urokinase type plasminogen activator ( uPA ) in a 24 fold excess to PAI 1 and were thereby profibrinolytic with regard to fibrinolysis antigen expression . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Arterial and coronary sinus blood were sampled concomitantly before cardioplegia and after release of the aortic cross clamp , for measurement of t PA antigen ( Ag ) and activity , plasminogen activator inhibitor ( PAI 1 ) Ag and activity , t PA / PAI 1 complex , single chain urokinase ( sc uPA ) and urokinase ( uPA ) plasminogen activators , the fibrin split product D dimer , thrombin antithrombin complex ( TAT ) , and the prothrombin split product F 1 + 2 . ^^^ Tissue plasminogen activator activity and t PA / PAI complex increased , PAI 1 activity decreased , while all other parameters were unchanged across the coronary circulation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have investigated the effect of TNF alpha on the synthesis and / or steady state mRNA levels of collagen , alkaline phosphatase ( ALP ) , plasminogen activators ( PAs ) and their inhibitor PAI 1 , and collagenases ( MMPs ) and their inhibitor TIMP 1 by human osteoblastic , HOS TE 85 , cells in monolayer cultures . ^^^ TNF alpha enhances urokinase plasminogen activator ( u PA ) activity and steady state mRNA levels twofold without affecting tissue plasminogen activator ( t PA ) or PAI 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Thrombospondin ( TSP ) and transforming growth factor beta 1 ( TGF beta ) promote human A 549 lung carcinoma cell plasminogen activator inhibitor type 1 ( PAI 1 ) production and stimulate tumor cell attachment in vitro . ^^^ PAI 1 , which is a natural inhibitor of tumor cell associated urokinase type plasminogen activator ( uPA ) activity , inhibited activation of plasminogen to plasmin in the growth media , thereby preventing plasmin induced detachment of cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Furthermore , both TGase inhibitors and a neutralizing antibody to TGase potentiated the effect of retinol in enhancing plasminogen activator ( PA ) levels in cultures of BAECs by suppressing the TGF beta mediated enhancement of PA inhibitor 1 ( PAI 1 ) expression . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the present study we have found that , in addition to a reduction in cellular proliferation , sodium butyrate induces the transient expression of plasminogen activator inhibitor type 1 ( PAI 1 ) in the LIM 2405 human colonic tumor cell . ^^^ Approximately 40 % of the PAI 1 secreted is biologically active as judged by the formation of higher molecular weight , SDS resistant complexes with urokinase plasminogen activator ( uPA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Processing of type 1 plasminogen activator inhibitor ( PAI 1 ) into the regulated secretory pathway . ^^^ To understand the processing of type 1 plasminogen activator inhibitor ( PAI 1 ) into the storage granules of platelets , we utilized a eukaryotic expression vector ( pRC / CMV ) to transfer the human cDNA for PAI 1 into AtT 20 cells , a mouse pituitary cell line known to sort proteins in a regulated fashion . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In this study , we measured the antigen levels of urokinase ( u PA ) , tissue plasminogen activator ( t PA ) , type 1 plasminogen activator inhibitor ( PAI 1 ) , and type 2 plasminogen activator inhibitor ( PAI 2 ) , and cancer tissue ( 19 adenocarcinomas and 19 squamous cell carcinomas ) and normal lung tissue . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Previous reports documented the inhibitory efficacy of different doses of aspirin on arachidonic acid ( AA ) induced platelet aggregation , however , the sensitivity of platelets toward other agonists as well as the effects of aspirin on platelet and plasma plasminogen activator inhibitor 1 ( PAI 1 ) release and levels were not investigated . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) was detectable in lavage of animals with HMD but not those with evolving DAD or BPD . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) , a M ( r ) 50 , 000 serine protease inhibitor , is the major physiological inhibitor of plasminogen activation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have characterized regulation of type 1 plasminogen activator inhibitor ( PAI 1 ) gene expression by phorbol 12 myristate 13 acetate ( PMA ) and the cAMP inducing agent forskolin in the human breast carcinoma cell line MCF 7 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor ( PAI 1 ) activity , fibrinogen , insulin , blood lipid , and blood pressure levels were studied in 20 GH deficient adults ( 10 men , 10 women ) 50 + / 11 years old with routine hormone replacement therapy ( except GH ) and compared with 20 healthy control subjects matched for sex , age , and body mass index . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The aim of this study was the evaluation of the in vitro production of prostacyclin , and of tissue plasminogen activator ( tPA ) and its inhibitor , PAI 1 , by human endothelial cells cultured in the presence of polyethylene terephthalate ( PET ) . ^^^ Tissue plasminogen activator concentration in the supernatants of the cultures in contact with the material was similar to that observed in the controls , while PAI 1 production was significantly reduced . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A large set of monoclonal antibodies has been raised against plasminogen activator inhibitor 1 ( PAI 1 ) and have been applied ( a ) for the development of various enzyme linked immunosorbent assays with various specificities towards the different forms of PAI 1 ; ( b ) for immunopurification purposes ; ( c ) for immunoprecipitation and immunoblotting experiments . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The two types of plasminogen activator , tissue type ( tPA ) and urokinase type ( uPA ) , are produced by osteoblasts , as is the specific PA inhibitor , PAI 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Both interferons caused a marked decrease in PAI 1 mRNA expression after 48 h with no change in urokinase type plasminogen activator ( u PA ) mRNA expression . ^^^ We conclude that IFN alpha and IFN gamma stimulate plasminogen mediated pericellular proteolysis of human RPE cells in culture by inhibiting PAI 1 gene expression . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We compared the plasma TM levels with the plasma levels of other specific markers of endothelial cell activation such as : prostacyclin ( PGI 2 ) , tissue type plasminogen activator ( t PA ) and plasminogen activator inhibitor ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In established normal rat kidney ( NRK ) cells , synthesis of the 52 kDa type 1 inhibitor of plasminogen activator [ p 52 ( PAI 1 ) ] is stimulated by the cell shape modulating fungal metabolite cytochalasin D ( CD ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The plasma level of plasminogen activator inhibitor 1 ( PAI 1 ) , however , did not change after the operation in the renal cell carcinoma group , and it decreased slightly in the transitional cell carcinoma group although it was not significant . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) , a member of the serine protease inhibitor ( Serpin ) superfamily , is the primary inhibitor of the plasminogen activators tPA and uPA . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Parathyroid hormone ( PTH ) , prostaglandin E 2 , ( PGE 2 ) or tumor necrosis factor alpha ( TNF alpha ) enhanced the secretion of urokinase type plasminogen activator ( u PA ) antigen and suppressed the secretion of plasminogen activator inhibitor 1 ( PAI 1 ) antigen to the conditioned medium . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Expression of plasminogen activator inhibitor type 1 ( PAI 1 ) by HT 29di human large bowel carcinoma cells is modulated as a function of epithelial differentiation . ^^^ Induction reflected specific changes in protein abundance , involving , most notably , a differentiation associated increase in the expression and substrate deposition of a 47 kDa protein with pI / mw two dimensional map coordinates and immunochemical properties identical to that of plasminogen activator inhibitor type 1 ( PAI 1 ) , a major regulator of the pericellular proteolytic cascade . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Role of platelet GpIIb / IIIa receptors in the modulation of platelet plasminogen activator inhibitors type 1 ( PAI 1 ) release . ^^^ This study was undertaken to determine the role of platelet glycoprotein ( GP ) IIb / IIIa receptors in the modulation of plasminogen activator type 1 ( PAI 1 ) release from human platelets as compared to other platelet functions . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The tissue ( tPA ) and urokinase ( uPA ) types of plasminogen activator and the plasminogen activator inhibitor 1 ( PAI 1 ) are enzymatic proteins that may play an important role in the degradation of the extracellular matrix in physiologic and neoplastic conditions . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
AIMS To identify the relative contribution of plasminogen activators , particularly tissue plasminogen activator ( t PA ) and specific plasminogen activator inhibitors ( PAI 1 , PAI 2 ) , to the fibrinolytic changes associated with various types of liver disease or severe chemical and physical damage to the liver . ^^^ Reduced PAI 1 activity in cirrhosis or a critical difference in the ratio of t PA to PAI 1 concentrations may explain the enhanced plasminogen activator activity previously noted in cirrhosis but not metastatic disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS Sections of normal and cirrhotic liver and liver with metastases were stained using the alkaline phosphatase antialkaline phosphatase ( APAAP ) technique and monoclonal antibody specific for plasminogen activator inhibitor ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Increased levels of plasminogen activator inhibitor 1 ( PAI 1 ) in human brain tumors . ^^^ Plasminogen activator inhibitor 1 ( PAI 1 ) is the most significant regulator of fibrinolysis in plasma , but little is known of the levels or activities of this important serpin in normal brain and brain tumors . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In vitro studies have shown that insulin and IGF 1 releases the fibrinolytic inhibitor plasminogen activator inhibitor 1 ( PAI 1 ) from cells of hepatic origin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Levels of plasminogen activator inhibitor 1 ( PAI 1 ) antigen secreted from HUVECs also increased up to 2 fold in concentration dependent fashion following addition of TNF alpha ( 10 100 U / ml ; 24 h ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The ability of n 3 fatty acids to modify tissue factor pathway inhibitor ( TFPI ) and tissue plasminogen activator inhibitor ( PAI 1 ) was also evaluated along with fibrinogen and thrombin antithrombin 3 ( TAT ) complexes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Seminal plasma ( N = 10 ) collected in the absence of extrinsic inhibitors had a mean of 25 + / 5 ng / ml uPA : PCI , 76 + / 23 ng / ml tPA : PCI , and 4 + / 2 ng / ml of tPA complexes with plasminogen activator inhibitor 1 ( tPA : PAI 1 ) . 93 % of the uPA and 17 % of the tPA antigen in seminal plasma was in complex with PCI and , when complexation was inhibited by collecting semen into an 1 , 10 phenanthrolinium solution , 33 % of the uPA and 7 % of the tPA was complexed to PCI . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Platelets contain a great deal of plasminogen activator inhibitor 1 ( PAI 1 ) , the principal endogenous inhibitor of tissue type plasminogen activator ( t PA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
If these commoner defects are not found , the rarer defects , including HC 2 , plasminogen or t PA deficiency , dysfibrinogenemia , or elevated PAI 1 , should next be sought . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma levels of antithrombin 3 ( AT 3 ) , protein C ( PC ) , plasminogen ( Pg ) and alpha 2 antiplasmin ( AP ) , total and free protein S ( PS ) , thrombin antithrombin 3 complex ( TAT ) , F1 . 2 fragment of prothrombin ( F1 . 2 ) , fibrinogen ( Fg ) , soluble fibrin monomers ( FM ) , tissue plasminogen activator ( t PA ) , plasminogen activator inhibitor 1 ( PAI 1 ) , total fibrinogen / fibrin degradation products ( TDP ) and D dimer ( DD ) were determined prior to the therapeutic regime , at the end of the treatment , and 24 hours later . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Regulation of endothelial cell ( EC ) plasminogen activator inhibitor type 1 ( PAI 1 ) , the primary physiological inhibitor of tissue type plasminogen activator ( TPA ) and urokinase type plasminogen activator ( UPA ) , by various stimuli has been well characterized . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We investigated the immunohistochemical localization of plasminogen activator inhibitor type 1 ( PAI 1 ) in surgical specimens of 41 human intracranial tumors . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In this paper , we describe a highly sensitive and specific , nonradioactive quantitative bioassay for TGF beta based on its ability to induce plasminogen activator inhibitor 1 ( PAI 1 ) expression . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor type 1 ( PAI 1 ) , a member of the serpin family of serine protease inhibitors , inhibits both tissue type plasminogen activator ( t PA ) and urokinase type plasminogen activator ( u PA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Zymographic analyses showed that tissue type plasminogen activator ( t PA ) occurred in association with casein micelles , partially as a complex with type 1 plasminogen activator inhibitor ( PAI 1 ) , whereas urokinase type plasminogen activator ( u PA ) was confined to milk leukocytes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Prognostic impact of urokinase type plasminogen activator and its inhibitor PAI 1 in completely resected gastric cancer . ^^^ The prognostic impact of the proteolytic factors urokinase type plasminogen activator ( uPA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) was evaluated in 76 completely resected gastric cancer patients enrolled in a prospective study . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have hypothesized that type 1 plasminogen activator inhibitor ( PAI 1 ) may exacerbate accumulation of extracellular matrix in atheroma by inhibiting local generation of plasmin and intramural proteolysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The relation of habitual diet and cardiorespiratory fitness to plasma fibrinogen concentration , Factor 7 activity ( F VIIc ) , Factor 10 activity ( F 10 ) , tissue plasminogen activator ( t PA ) , plasminogen activator inhibitor 1 ( PAI 1 ) concentrations , anti thrombin 3 ( AT 3 ) and apolipoprotein ( a ) ( Apo [ a ] ) was analyzed in 111 normolipidemic men aged 51 53 years . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In a group of 18 patients with thrombosis of the fistula euglobulin fibrinolysis without stimulus ( 340 + / 48 min . ) was longer , also after veno occlusion ( 199 + / 50 min . ) , as compared with the group without thrombosis ( 277 + / 38 and 121 + / 27 min . resp . ) and the level of the inhibitor of the plasminogen activator ( PAI 1 ) differed : 3 . 3 + / 0 . 6 i . u . as compared with 2 . 6 + / 0 . 8 i . u . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the fibrinolytic system , tissue plasminogen activator ( tPA ) localization and immunoreactivity were comparable in all eyes , but plasminogen activator inhibitor 1 ( PAI 1 ) immunoreactivity was elevated within the walls of retinal vessels in the sickle cell tissue . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We investigated the release of plasminogen activator inhibitor type 1 ( PAI 1 ) from cultured vascular endothelial cells after exposure to basic fibroblast growth factor ( bFGF ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
PATIENTS AND METHODS : Components of the fibrinolytic system ( i . e . , PAI 1 , t PA , fibrinogen , plasminogen , and alpha 2 antiplasmin ) were determined in 100 patients with AMI . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Increased insulin levels are also associated with increases in the anti fibrinolytic factor , plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Parameters of fibrinolysis , including basal plasma tissue type plasminogen activator ( t PA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) antigen levels were studied in 49 non insulin dependent diabetic patients ( 23 men , 26 women : ages 51 . 3 + / 14 . 9 years ) and 16 age matched non diabetic subjects ( 9 men , 7 women ages 49 . 8 + / 12 . 2 years ) as a control group . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) levels in patients with chronic venous leg ulceration . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
There were decreases in AT , factors 5 , 2 , 10 , 9 , protein S ( total and free ) , C4b binding protein , thrombomodulin , and platelets counts , whereas heparin , ACT , thrombospondin , plasminogen activator inhibitor ( PAI 1 ) , and tissue plasminogen activator ( tPA ) increased . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS AND RESULTS : To determine if the failure to lyse pulmonary thromboemboli is caused by the local expression of the primary inhibitor of tissue type plasminogen activator ( type 1 plasminogen activator inhibitor , PAI 1 ) , levels of PAI 1 antigen and mRNA were analyzed by immunohistochemistry and in situ hybridization in specimens harvested from a series of patients during pulmonary thromboendarterectomies . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue plasminogen activator ( tPA ) and plasminogen activator inhibitor 1 ( PAI 1 ) have been pointed out as markers for deep venal thrombosis , acute myocardial infarction and several thrombotic disorders . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The fibrinolytic system is part of the defense against thrombotic and cardiovascular events , but so far no study has shown that clinical measurements of fibrinolytic key components such as tissue plasminogen activator ( t PA ) or plasminogen activator inhibitor type 1 ( PAI 1 ) have any predictive value beyond 3 years . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the corn oil group , plasminogen activator inhibitor ( PAI 1 ) decreased significantly but in the cod liver oil group , PAI 1 remained unchanged . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitors in the blood , that is , notably plasminogen activator inhibitor type 1 ( PAI 1 ) , bind circulating tissue type plasminogen activator ( t PA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
As determined by histopathological methods , the malignant tumors showed statistically significantly higher expression of urokinase plasminogen activator ( uPA ) , type 1 plasminogen activator inhibitor ( PAI 1 ) , and especially urokinase plasminogen activator receptor ( uPAR ) than benign tissues . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
As a test of this hypothesis , sex hormones and fibrinogen , factor 7 and plasminogen activator inhibitor ( PAI 1 ) , hemostatic factors recently shown to be risk factors for myocardial infarction , were measured in men with hypertension and in healthy control subjects . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Reduced GFA in fibrin associated GN was associated with decreased expression of tissue type plasminogen activator ( tPA ) and increased expression of plasminogen activator inhibitor type 1 ( PAI 1 ) and glomerular macrophage infiltration . ^^^ These studies demonstrate that fibrin deposition in GN is associated with a net reduction of GFA , attributable to reduced expression of plasminogen activators and augmentation of PAI 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The roles of alpha 2 antiplasmin and plasminogen activator inhibitor 1 ( PAI 1 ) in the inhibition of clot lysis . ^^^ The relative importance of the two major inhibitors of fibrinolysis , alpha 2 antiplasmin ( alpha 2 AP ) and plasminogen activator inhibitor ( PAI 1 ) , were investigated using a simple microtitre plate system to study fibrin clot lysis in vitro . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
It shows substantial resistance to the fast acting inhibitor , plasminogen activator inhibitor 1 ( PAI 1 ) , requiring a 10 fold greater molar excess of PAI 1 to reduce its activity by 50 % , compared to t PA . ^^^ These results show that it is possible to combine mutations in different domains of t PA to construct a variant which is simultaneously slower clearing , less reactive towards plasminogen in the absence of a fibrin clot , and resistant to inactivation by PAI 1 . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
There were no important effects of saruplase on overall blood coagulation ( activated partial thromboplastin time ) and platelet function ( collagen induced platelet aggregation , urinary [ 2 , 3 dinor ] thromboxane B 2 excretion and plasminogen activator inhibitor 1 [ PAI 1 ] release from platelets ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We then measured the antigen levels of total PAI 1 and t PA PAI 1 complex in the lyzed solutions of PRP clot and PPP clot to analyse the possible effect of plasminogen activator inhibitor 1 ( PAI 1 ) present in platelets . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma levels of t PA ( tissue plasminogen activator ) and t PA PAI 1 ( plasminogen activator inhibitor 1 ) complex increased with increase in age , but those of PAI 1 ( total and free ) did not change in controls . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Four patients had elevated levels of plasminogen activator inhibitor ( PAI 1 ) and one patient had an inadequate increase in tissue plasminogen activator ( tPA ) post venous occlusion . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Defined abnormalities include congenital dysfunction and deficiency of plasminogen , and probably impaired plasminogen activation secondary to elevated levels of plasminogen activator inhibitor type 1 ( PAI 1 ) or to impaired release of tissue plasminogen activator ( tPA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Angiotensin 2 ( ANG 2 ) stimulates plasminogen activator inhibitor 1 ( PAI 1 ) gene expression in astroglial cells prepared from rat brains . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Because of the frequent occurrence of premature cardiovascular disease in patients with non insulin dependent , type 2 diabetes mellitus ( NIDDM ) , the attenuated fibrinolytic activity of plasma from type 2 diabetic patients with increased concentrations of plasminogen activator inhibitor type 1 ( PAI 1 ) , and the fact that insulin stimulates synthesis of PAI 1 by human hepatic cells in vitro , we and others have hypothesized that accelerated vascular disease in type 2 diabetes may result in part from impaired fibrinolysis secondary to excessive elaboration of PAI 1 stimulated by insulin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The strongest relations between insulin and hemostatic factors were observed with fibrinolytic variables , particularly plasminogen activator inhibitor 1 ( PAI 1 ) levels ( r = . 44 , P < . 0001 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The content of plasminogen ( PLG ) and plasminogen activator inhibitor 1 ( PAI 1 ) were higher in the patients with essential hypertension than in the controls . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In our study , we measured resting tissue type plasminogen activator ( t PA ) activity and resting plasminogen activator inhibitor 1 ( PAI 1 ) activity in 15 healthy men and in 20 patients ( male ) with coronary heart disease in the morning and evening . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Type 1 plasminogen activator inhibitor ( PAI 1 ) is the major physiological inhibitor of plasminogen activation , inhibiting both tissue and urokinase type plasminogen activators . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We investigated the effect of cadmium ( 0 . 5 , 1 . 0 or 2 . 0 microM ) on the release of plasminogen activator inhibitor 1 antigen ( PAI 1 : Ag ) from cultured human vascular endothelial cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The first case showed an increase in plasminogen activator inhibitor 1 ( PAI 1 ) activity , and the second case had a decrease in platelet aggregation induced by adenosine diphosphate and adrenaline but normal with collagen . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Homozygous plasminogen activator inhibitor 1 ( PAI 1 ) deficient ( PAI 1 / ) mice were generated by homologous recombination in D 3 embryonic stem cells . ^^^ SDS gel electrophoresis of plasma incubated with 125I labeled recombinant human tissue type plasminogen activator revealed an approximately 115 , 000 M ( r ) component with plasma from endotoxin stimulated ( 0 . 5 mg / kg ) PAI 1+ / + but not from PAI 1 / mice , which could be precipitated with a polyclonal anti PAI 1 antiserum . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The effects of plasminogen activator inhibitor 1 ( PAI 1 ) gene inactivation on hemostasis , thrombosis and thrombolysis were studied in homozygous PAI 1 deficient ( PAI 1 / ) mice , generated by homologous recombination in D 3 embryonic stem cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue plasminogen activator ( tPA ) , plasminogen activator inhibitor 1 ( PAI 1 ) and von Willebrand factor ( vWF ) , all of endothelial origin and active in the haemostasis , were analysed in 74 patients with rheumatoid arthritis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
SMC of different origin responded to thrombin treatment with a dose and time dependent increase in tissue type plasminogen activator ( t PA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) levels in both cell lysates and conditioned media with maximum effects achieved at 10 20 IU / ml thrombin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Antigens of tissue plasminogen activator ( t PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) were measured . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The role of defective fibrinolysis caused by elevated activity of plasminogen activator inhibitor 1 ( PAI 1 ) in promoting fibrin deposition in vivo has not been well established . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Constitutive biosynthesis of plasminogen activator inhibitor type 1 ( PAI 1 ) by cultured human aortic endothelial cells independent of insulin . ^^^ BACKGROUND : Both tissue type plasminogen activator ( t PA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) are synthesized by vascular endothelium , whereas hepatocytes synthesize PAI 1 but not t PA . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have studied the prognostic value of urokinase type plasminogen activator ( uPA ) and type 1 plasminogen activator inhibitor ( PAI 1 ) in tumor extracts from 106 patients with adenocarcinoma of the lung . uPA and PAI 1 levels were determined by sandwich enzyme linked immunosorbent assays . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The present study was undertaken to investigate the role of plasminogen activator inhibitor type 1 ( PAI 1 ) and activated protein C ( APC ) in the regulation of tumor cell invasion . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Obese and diabetic subjects had threefold elevations of plasma concentrations of plasminogen activator inhibitor type 1 ( PAI 1 ) compared with values in lean control subjects . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
For these analyses we cloned partial rabbit cDNAs for apolipoprotein A 1 ( apoA 1 ) , apolipoprotein B ( apoB ) , apolipoprotein E ( apoE ) , cholesteryl ester transfer protein ( CETP ) , hepatic lipase ( HL ) , lipoprotein lipase ( LPL ) , HMG CoA reductase , LDL receptor , 7 alpha hydroxylase , albumin , bile salt dependent cholesteryl ester hydrolase ( CEH ) , lecithin : cholesterol acyl transferase ( LCAT ) , and plasminogen activator inhibitor protein 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The balance between the EC derived fibrinolytic components , plasminogen activator ( tPA ) , and plasminogen inhibitor ( PAI 1 ) contributes to maintaining thromboresistance . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The tissue type plasminogen activator ( t PA ) level was increased , but it was well correlated with the plasminogen activator inhibitor 1 ( PAI 1 ) level . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To assess the actual degree of activation of coagulation systems and vascular disorders in hypercholesterolemia , plasma levels of vascular endothelial cell markers , such as thrombomodulin ( TM ) , tissue type plasminogen activator , plasminogen activator inhibitor 1 ( PAI 1 ) , and von Willebrand factor , were measured in 51 patients with hypercholesterolemia . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We examined vascular endothelial cell markers , thrombomodulin ( TM ) , plasminogen activator inhibitor 1 ( PAI 1 ) , tissue plasminogen activator ( t PA ) , and von Willebrand factor , in 80 patients with disseminated intravascular coagulation ( DIC ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fibrinogen , von Willebrand factor antigen , FVIII : C , thrombin antithrombin 3 complex ( TAT 3 ) , fibrin monomers ( FM ) , plasminogen activator inhibitor 1 ( PAI 1 ) and D dimers were tested . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Most notable were the strong associations of fibrinolysis parameters tissue plasminogen activator antigen and plasminogen activator inhibitor activity ( PAI 1 ) with total and very low density lipoprotein ( VLDL ) triglycerides . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE To compare the activity of plasminogen activator inhibitor ( PAI 1 ) in diabetic and non diabetic patients admitted with acute myocardial infarction and to determine whether PAI 1 activity influences reperfusion after thrombolytic therapy . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : Both vascular disease and elevated concentrations in plasma of plasminogen activator inhibitor type 1 ( PAI 1 ) are prominent in patients with non insulin dependent diabetes mellitus ( NIDDM ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Increased plasminogen activator inhibitor 1 ( PAI 1 ) activity has been reported in Type 2 ( non insulin dependent ) diabetes and is a recognized risk factor for coronary artery disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Although platelet alpha granules contain plasminogen activator inhibitor 1 ( PAI 1 ) , a fast acting inhibitor of t PA , the contribution of PAI 1 to the antifibrinolytic effect of platelets has remained a subject of controversy . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To clarify age related and lipid related hemostatic abnormalities in the elderly , we measured the plasma levels of active PAI 1 antigen ( aPAI 1 ) , tPA PAI 1 complex ( TPC ) , plasminogen , alpha 2 plasmin inhibitor ( alpha 2 PI ) , plasmin alpha 2 PI complex ( PIC ) , and D dimer , together with the plasma levels of fibrinogen , factor 7 ( F 7 ) , and thrombin antithrombin 3 complex ( TAT ) and the serum lipid levels in 68 hyperlipidemic and 82 normolipidemic elderly subjects . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Prognostic value of urokinase type plasminogen activator ( uPA ) and plasminogen activator inhibitors PAI 1 and PAI 2 in breast carcinomas . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Although platelets contain approximately 90 % of the total amount of plasminogen activator inhibitor type 1 ( PAI 1 ) present in blood , the functional significance of PAI 1 in platelets has been controversial . ^^^ This study was performed to determine whether elaboration of PAI 1 from platelets activated physiologically by thrombolysis of pre formed clots inhibits activation of plasminogen by tissue type plasminogen activator ( t PA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The coagulant response to a number of stimuli is regulated by the expression of tissue factor , but the role of the plasminogen activator inhibitors , PAI 1 and PAI 2 , in contributing to the net coagulant response is not known . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Recent findings have elucidated the mechanism for clearance from the extracellular space of the two types of plasminogen activators , urokinase type plasminogen activator ( u PA ) and tissue type plasminogen activator ( t PA ) , and their type 1 inhibitor ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Quantitative zymography and enzyme linked immunosorbent assay were used to determine the amounts of urokinase type plasminogen activator ( u PA ) , tissue type plasminogen activator , and plasminogen activator inhibitors type 1 and type 2 ( PAI 1 and PAI 2 ) in benign and malignant primary brain tumors ( n = 28 ) as well as nonneoplastic brain ( n = 5 ) . u PA and PAI 1 antigen were undetectable in normal brain but significantly elevated in glioblastoma multiforme ( u PA , 2 . 86 + / 3 . 01 ng / mg ; PAI 1 , 8 . 19 + / 5 . 57 ng / mg ; P < 0 . 001 ) . ^^^ These findings indicate that malignancy in primary CNS neoplasms is associated with elevated levels of u PA and PAI 1 , supporting the role of the plasminogen plasmin system in the pathogenesis of CNS malignancy and as a potential biomarker and therapeutic target . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In addition , both PAs can be complexed with the plasminogen activator inhibitors PAI 1 or PAI 2 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Structure function relationship and molecular interaction of type 1 plasminogen activator inhibitor ( PAI 1 ) ] . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A reduced release of t PA was found in 4 patients , while 10 out of 14 patients had comparatively higher levels of plasminogen activator inhibitor ( PAI 1 ) . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Eight hours after the intake of 100g of butter , plasminogen activator inhibitor 1 ( PAI 1 ) level in plasma was significantly higher and euglobulin clot lysis time was significantly prolonged compared to those of the control group . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Such alterations include increased plasma concentrations of fibrinogen , Factor 7 coagulant activity and plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We investigated the possible role of type 1 plasminogen activator inhibitor ( PAI 1 ) on success or failure of thrombolytic therapy with recombinant tissue plasminogen activator ( rt PA ) in 10 responders and 10 non responders with acute myocardial infarction and early initiation of therapy within 2 h of onset using the common infusion scheme ( 100 mg rt PA over 3 h ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Glomerular plasminogen activator inhibitor 1 ( PAI 1 ) steady state mRNA and bioactivity were increased after the induction of an augmented form of antiglomerular basement membrane ( GBM ) antibody glomerulonephritis . ^^^ PAI 1 mRNA expression correlated with glomerular PAI 1 bioactivity as determined by a functional tissue type plasminogen activator ( t PA ) binding assay . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To determine whether oxidized low density lipoprotein ( Ox LDL ) , which accumulates in atherosclerotic arteries , modulates the endothelial fibrinolytic system , cultures of human umbilical vein endothelial cells were incubated with low density lipoproteins or lipids , and levels of plasminogen activator inhibitor 1 ( PAI 1 ) and tissue type plasminogen activator ( t PA ) antigens in the conditioned medium were measured by enzyme linked immunosorbent assay . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The main physiological inhibitor of the plasminogen activators is plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We studied the plasminogen activation system in tumor tissue by measuring the antigen level of the 2 plasminogen activators , tissue type ( t PA ) and urokinase type ( U PA ) and their inhibitors , plasminogen activator inhibitors type 1 ( PAI 1 ) and type 2 ( PAI 2 ) in the tissue extracts of 43 human benign and malignant ovarian tumors . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the present report , we describe that affinity purified gp 330 from rabbit renal cortex binds plasminogen activator inhibitor type 1 ( PAI 1 ) complexed with urokinase type plasminogen activator ( uPA ) . alpha 2M methylamine , which binds with high affinity to alpha 2MR / LRP , did not bind to gp 330 . ^^^ The binding was calcium dependent and inhibited by recombinant RAP ( rRAP ) and tissue type plasminogen activator PAI 1 complexes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The cardiovascular risk factor plasminogen activator inhibitor type 1 ( PAI 1 ) has been associated with abdominal obesity , hypertension , hypertriglyceridemia , hyperinsulinemia , glucose intolerance , and type 2 diabetes , conditions known to be linked with insulin resistance . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In our search for compounds that can stimulate endogenous fibrinolysis , we have found that certain triazolobenzodiazepines enhance the production of tissue type plasminogen activator ( t PA ) by vascular endothelial cells maintained in vitro , with no or even a lowering effect on plasminogen activator inhibitor type 1 ( PAI 1 ) production . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
No significant changes in plasma D dimer and fibrinogen values were detected in the two groups . tPA , urokinase type plasminogen activator , PAI 1 and procoagulant activity were evaluated in vitro on cultured human endothelial cells and found to be unchanged following GM CSF addition . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma insulin , C peptide and plasminogen activator inhibitor 1 ( PAI 1 ) levels were measured in 64 men with coronary artery disease ( CAD ) documented by angiography . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In order to elucidate the influence of the risk factors of coronary heart disease on the fibrinolytic activity , relationships between blood pressure , body mass index ( BMI ) , plasma lipoprotein ( a ) ( Lp ( a ) ) level and the plasma levels of tissue plasminogen activator ( tPA ) and plasminogen activator inhibitor 1 ( PAI 1 ) were analyzed in the subjects with mild hypertension . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The mass concentrations and activity of tissue plasminogen activator ( tPA ) and plasminogen activator inhibitor ( PAI 1 ) in plasma were measured three months after the infarction . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Levels of prothrombin fragments 1+2 ( F1+2 ) , tissue plasminogen activator antigen ( t PA ) , plasminogen activator inhibitor 1 activity ( PAI 1 ) , D dimer and interleukin 6 ( IL 6 ) were measured in arterial ( AB ) and mixed venous blood ( MVB ) in five patients during and after total hip replacement operation with acrylic cement prosthesis fixation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A murine model of partial hepatectomy ( PH ) was employed to investigate type 1 plasminogen activator inhibitor ( PAI 1 ) gene expression in regenerating liver . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Production of plasminogen activator inhibitor type 1 ( PAI 1 ) by plaque macrophages ( 6 . 7 + / 2 . 7 ng / 10 ( 5 ) cells / 24 hours [ mean + / SEM ] ) was significantly greater than PAI 1 production by blood monocytes isolated simultaneously from the same patients ( 1 . 8 + / 1 . 5 ng / 10 ( 5 ) cells / 24 hours ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In this study , we evaluated the levels of t PA activity , t PA antigen and plasminogen activator inhibitor 1 ( PAI 1 ) in blood from the patients with central serous chorioretinopathy , and compared them with the levels of total cholesterols ( TCH ) , triglycerides ( TG ) , and high density lipoprotein cholesterol ( HDL ) . t PA activity levels and HDL were lower than in standard controls but t PA antigen , PAI 1 antigen , and TG were higher . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
O 2 stressed cells accumulated significantly greater ECM levels ( approximately 3 to 4 fold that of control cells ) of a 52 kDa glycoprotein ( p 52 ) , recently identified as the matrix form of plasminogen activator inhibitor type 1 ( PAI 1 ) ( P . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The progestin medroxyprogesterone acetate ( MPA ) enhanced expression of the endothelial type plasminogen activator inhibitor PAI 1 by stromal cells from cycling endometrium and by decidual cells from first trimester endometrium . ^^^ Extrapolation of these in vitro results to periimplantational events in humans suggests that under progesterone regulation , decidual cell derived PAI 1 could 1 ) restrain blastocyst invasion of the stroma by inhibiting trophoblast associated urokinase type plasminogen activator , and 2 ) prevent hemorrhage during trophoblast invasion of the endometrial vasculature by inhibiting fibrinolysis mediated by tissue type plasminogen activator . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The latent form of type 1 plasminogen activator inhibitor ( PAI 1 ) acquires inhibitory activity by denaturation followed by refolding . ^^^ We show here that the reactions of denatured / refolded PAI 1 with plasminogen activators are affected by low concentrations of SDS , which may remain after using SDS for denaturation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : A single kindred in North America with venous thrombosis was described as having defective fibrinolysis because of increased levels of plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The effects of native and acetylated low density lipoproteins ( LDLs and acetyl LDLs , respectively ) on the release of plasminogen activator inhibitor type 1 ( PAI 1 ) by cultured human umbilical vein endothelial cells ( ECs ) were evaluated . ^^^ The effect of LDL and acetyl LDL was concentration dependent and specific for PAI 1 because tissue type plasminogen activator and expression of procoagulant activity were not affected by either lipoprotein . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Urokinase type plasminogen activator ( u PA ) , its receptor ( u PAR ) , and type 1 inhibitor ( PAI 1 ) in cultured human mesangial cells were investigated . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In contrast to the differing effects of TGF beta on cell growth , we found that all these cell types showed strong induction of most of the mRNA and protein species examined , including fibronectin , collagen 4 , laminin , type 4 collagenase , urokinase type plasminogen activator ( uPA ) , and plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
As compared to baseline , 10 g oat husk supplementation per day resulted in a reduction of plasma plasminogen activator inhibitor type 1 ( PAI 1 ) activity ( p < 0 . 05 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
High plasma plasminogen activator inhibitor 1 ( PAI 1 ) activity is associated with insulin resistance and is correlated with hyperinsulinemia . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
High levels of urokinase type plasminogen activator and its inhibitor PAI 1 in cytosolic extracts of breast carcinomas are associated with poor prognosis . ^^^ The prognostic value of urokinase type plasminogen activator ( uPA ) and type 1 plasminogen activator inhibitor ( PAI 1 ) levels in cytosolic extracts of ductal breast carcinomas was studied , retrospectively , in 118 premenopausal and 72 postmenopausal high risk patients entered into the protocol of Danish Breast Cancer Cooperative Group trials for adjuvant treatment of breast cancer . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The two allele sequences of a common polymorphism in the promoter of the plasminogen activator inhibitor 1 ( PAI 1 ) gene respond differently to interleukin 1 in HepG 2 cells . ^^^ We have detected a common ( allele frequency 0 . 53 / 0 . 47 ) single base pair insertion / deletion polymorphism 675 base pairs upstream from the start of transcription of the plasminogen activator inhibitor 1 ( PAI 1 ) gene , using the chemical cleavage mismatch analysis . `` Band shift assays ' ' suggest that the allele with the single base pair insertion contains an additional protein binding site which is not present in the del allele . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Previous studies have identified plasminogen activator inhibitor type 1 ( PAI 1 ) dependent t PA binding sites in the human hepatoma cell line HepG 2 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Active plasminogen activator inhibitor ( PAI 1 ) antigen , t PA , and urokinase plasminogen activator antigen levels fell significantly after OC treatment and remained low during OC treatment . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have explored TMp in patients with atheromatous disease and compared its level with others endothelial cell markers , particularly those who indicate cell activation , as tissue type plasminogen activator ( t PA ) , inhibitor of plasminogen activator ( PAI 1 ) and prostacyclin ( PG 12 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
DESIGN : Tissue plasminogen activator activity ( t PA ) and antigen ( t PAAg ) and plasminogen activator inhibitor Type 1 antigen ( PAI 1 ) were measured in homogenates of endometrium sampled between 24 and 36 h after the onset of menstruation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Of the hemostatic variables , plasminogen activator inhibitor 1 ( PAI 1 ) , plasma antiplasmin , plasma fibrinogen , and urine beta thromboglobulin concentrations were significantly elevated in patients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The interaction of endothelin 1 ( ET 1 ) with either interleukin 1 beta ( IL 1 beta ) or tumor necrosis factor alpha ( TNF alpha ) on the release of tissue plasminogen activator antigen ( t PA : Ag ) and plasminogen activator inhibitor 1 antigen ( PAI 1 : Ag ) was investigated in a culture system of vascular endothelial cells derived from human umbilical vein . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Immunohistochemical localization of plasminogen activator inhibitor 1 ( PAI 1 ) was studied using the streptavidin biotin method in human atherosclerotic coronary arteries . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The variables measured were serum oestradiol content , plasma antithrombin 3 ( AT 3 ) activity , protein C activity and the plasma concentrations of tissue type plasminogen activator ( t PA ) antigen , plasminogen activator inhibitor ( PAI 1 ) antigen , and fibrinogen . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The article contains a survey of the recent papers on the fibrinolytic inhibitors which regulate the process of plasminogen activation PAI 1 and PAI 2 . ^^^ PAI 1 , secreted mainly by endothelial cells and platelets , is the main plasmic inhibitor of plasminogen activation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Local accumulation of plasminogen activator inhibitor 1 ( PAI 1 ) in response to thrombosis has been implicated not only in inhibition of fibrinolysis but also in the pathogenesis of vascular disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Despite normal or high tissue plasminogen activator ( tPA ) and plasminogen activator inhibitor ( PAI 1 ) antigen levels , the plasma PAI 1 activity and the formation of tPA / PAI 1 complexes were lower in APL patients than in normal controls , suggesting a proteolytic degradation of PAI 1 , not able to complex tPA . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The importance of a specific variable region in different serine proteases for the interaction with plasminogen activator inhibitor 1 ( PAI 1 ) is studied . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Assays of the fibrinolytic system included euglobulin clot lysis times ( ECLT ) , tissue plasminogen activator ( tPA ) , and plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Type 1 plasminogen activator inhibitor ( PAI 1 ) may be markedly increased in the plasma of patients with endotoxemia and / or renal disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Impact of weight loss on plasminogen activator inhibitor ( PAI 1 ) , factor 7 , and other hemostatic factors in moderately overweight adults . ^^^ Measurements of plasminogen activator inhibitor 1 ( PAI 1 ) antigen , tissue type plasminogen activator ( t PA ) antigen , D dimer antigen , factor 7 activity , fibrinogen , and protein C antigens were made at baseline and after 6 months in 90 men and 88 women . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the absence of accessory components , plasminogen activator inhibitor 1 ( PAI 1 ) rapidly forms equimolar , inactive complexes both with tissue type ( t PA ) and with urokinase type ( u PA ) plamsinogen activator . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Recently inflamed peritoneal tissue has been shown to have reduced fibrinolytic activity secondary to increased levels of plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Insulin therapy in type 2 diabetic subjects suppresses plasminogen activator inhibitor ( PAI 1 ) activity and proinsulin like molecules independently of glycaemic control . ^^^ Activity of plasminogen activator inhibitor ( PAI 1 ) , a fast acting inhibitor of fibrinolysis , decreased significantly ( 14 . 3 % + / 27 . 5 % ; p = 0 . 02 ) but no changes occurred in concentration of lipoproteins or apoproteins between therapies . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Recent studies suggest that plasminogen activator inhibitor ( PAI 1 ) may be a risk factor for recurrent myocardial infarction . ^^^ We measured PAI 1 activity and antigen and tissue type plasminogen activator ( t PA ) antigen in 35 ( 20 nondiabetic and 15 diabetic ) subjects with no clinical or electrocardiographic evidence of ischemic heart disease and in 74 ( 50 nondiabetic and 24 diabetic subjects ) who had survived a myocardial infarction in the preceding 6 24 months . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor type 1 ( PAI 1 ) , the physiologic inhibitor of both tissue type plasminogen activator ( tPA ) and urokinase type plasminogen activator ( uPA ) , is a major biosynthetic product of endothelial cells in vitro ; endothelial cells in vivo , in contrast , do not appear to produce significant amounts of PAI 1 as made evident by in situ hybridization studies in normal mice . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have investigated the role of plasminogen activator inhibitor 1 ( PAI 1 ) in the regulation of fibrinolysis using a model thrombus composed of thrombin stimulated platelets , fibrin ( ogen ) , plasminogen , and recombinant tissue type plasminogen activator . ^^^ This delay in lysis was almost fully reversed by the addition of a PAI 1 specific monoclonal antibody that blocks the ability of PAI 1 to inhibit plasminogen activators . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Thromb . 11 : 1821 1829 ) we have shown that oxidized low density lipoproteins ( ox LDL ) stimulated the synthesis and secretion of plasminogen activator inhibitor 1 ( PAI 1 ) by human umbilical vein endothelial cells ( HUVEC ) in culture . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This led to a decrease in hematocrit ( 35 . 5 + / 6 . 3 > 31 . 8 + / 5 . 6 % , P < 0 . 01 ) , fibrinogen , and platelets , as well as a decrease in fibrinolysis ( Euglobulin Clot Lysis Time increases 246 + / 52 > 300 + / 46 min and fast acting plasminogen activator inhibitor 1 [ PAI 1 ] activity increases 10 . 5 + / 6 . 9 > 15 . 1 + / 9 IU / mL , P < 0 . 01 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The occurrence of type 1 plasminogen activator inhibitor ( PAI 1 ) in human cerebrospinal fluid ( CSF ) has not previously been reported . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activators are inhibited by plasminogen activator inhibitors 1 ( PAI 1 ) and 2 ( PAI 2 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Venous blood samples were taken at time 0 , 3 , 6 , 25 and 49 h for assay of fibrinogen ( Fbg ) , fibrinopeptide A ( FPA ) , total fibrin ( ogen ) degradation products ( TDP ) , fibrin degradation products ( FbDP ) , fibrinogen degradation products ( FgDP ) , cross linked fibrin degradation products ( XL FDP ) , tissue plasminogen activator ( tPA ) , urinary type plasminogen activator ( u PA ) , plasminogen , alpha 2 antiplasmin ( alpha 2 AP ) and plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
These proteins were identified as the previously described 54 kDa protein inducible in interferon gamma sensitive cell types and type 1 plasminogen activator inhibitor ( PAI 1 ) , respectively . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor type 1 ( PAI 1 ) is the primary physiologic inhibitor of the naturally occurring plasminogen activators . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The present study was carried out to explore the possible relation of plasma plasminogen activator inhibitor 1 ( PAI 1 ) , fibrinogen , and factor 7 levels to other risk factors for coronary heart disease ( CHD ) and to serum sex hormone levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Since platelets are a physiological reservoir for the plasminogen activator inhibitor ( PAI 1 ) contained in plasma , we evaluated plasma and platelet tissue plasminogen activator ( tPA ) and PAI 1 in 20 ET patients with and without thrombotic complications and in 13 control subjects . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
High levels of histidine rich glycoprotein ( HRGP ) and plasminogen activator inhibitor 1 ( PAI 1 ) have been claimed to contribute to the hypofibrinolytic state observed in patients with venous thrombosis . ^^^ Binding of tissue plasminogen activator ( t PA ) by PAI 1 may induce hypofibrinolysis . ^^^ Plasminogen activation was performed by adding plasma to fibrin surfaces to which t PA had been previously bound in the presence of 40 mg / ml bovine serum albumin and 20 mumol / L of the lysine analog trans 4 ( aminomethyl ) cyclohexane carboxylic acid to prevent nonspecific binding and thereby the inhibitory effect of elevated PAI 1 levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In normal rat kidney ( NRK ) cells , synthesis of the 52 kDa substrate associated type 1 inhibitor of plasminogen activator [ p 52 ( PAI 1 ) ] is linked to alterations in cell shape and substrate adhesion . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Increased concentrations of plasminogen activator inhibitor 1 ( PAI 1 ) were detected in endothelial cell conditioned medium following treatment with rt TSP 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is present in the platelet alpha granule and is released on platelet activation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Blood samples were obtained on days 1 , 4 , and 7 after hospital admission to measure tissue type plasminogen activator antigen ( t PA ) , urokinase type plasminogen activator ( u PA ) , plasminogen activator inhibitor antigen ( PAI 1 ) , plasminogen , alpha 2 antiplasmin , fibrinogen , antithrombin 3 , protein C , protein S , thrombin antithrombin complexes ( TAT ) , D dimer , and von Willebrand factor related antigen ( vWF : Ag ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitors ( PAI 1 and PAI 2 ) in normal pregnancies , pre eclampsia and hydatidiform mole . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Lysis of blood clots from vehicle and retinoic acid treated rats could be completely blocked by addition of tranexamic acid or antibodies against rat t PA before clot formation . t PA activity in plasma was slightly increased after retinoic acid treatment ; no effects were measured on plasma PAI 1 , u PA , plasminogen , and alpha 2 antiplasmin levels . t PA activity in lung and kidney was marginally enhanced by retinoic acid but in heart and aortic tissue extracts t PA activity was increased by about 50 % . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In this study the effect of vitamin A status and retinoid treatment on the activity of tissue type plasminogen activator ( TPA ) and its inhibitor , plasminogen activator inhibitor type 1 ( PAI 1 ) , in plasma and in several tissues was investigated in BN / BiRij rats . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
By an in situ hybridization technique , we have studied gene expression of plasminogen activator inhibitor 1 ( PAI 1 ) in human renal tissue showing severe acute vascular rejection ( n = 8 ) , clinically irreversible ( chronic ) vascular rejection ( n = 3 ) , mild vascular rejection ( n = 8 ) , parenchymal rejection ( n = 4 ) , ' normal ' kidneys ( n = 6 ) , and non rejecting kidneys ( n = 6 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
These features of alpha 2 PI and its complex with plasmin are similar to those of plasminogen activator inhibitor type 1 ( PAI 1 ) and its complex with plasminogen activators ( PAs ) , thus they may represent some common features of the SERPINS . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In four normotensive subjects and six hypertensive patients , we investigated whether infusion of angiotensin 2 ( Ang 2 ) affected circulating levels of plasminogen activator inhibitor 1 ( PAI 1 ) , the most important physiological inhibitor of tissue type plasminogen activator ( t PA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In this work we have investigated the effects of SDS on the stability of complexes between single chain or two chain tissue plasminogen activator ( t PA ) and its inhibitor ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor type 1 ( PAI 1 ) levels produced by HFMEC remained unaffected by IL 4 , whereas tissue type plasminogen activator ( t PA ) levels were slightly decreased when HFMEC were treated with IL 4 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Lastly , the simulation predicted that 6 months of endurance training produced a decrease in resting plasminogen activator inhibitor type 1 ( PAI 1 ) secretion , resulting in less t PA inhibition and an overall increase in active t PA after training . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Using gonadotropin induced ovulation as a model , we have studied how two components of the PA system , tissue type plasminogen activator ( tPA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) , are regulated temporally and spatially by gonadotropins , leading to the initiation and termination of a well directed proteolytic process . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Functional display of human plasminogen activator inhibitor 1 ( PAI 1 ) on phages : novel perspectives for structure function analysis by error prone DNA synthesis . ^^^ The synthesis of the human plasminogen activator inhibitor 1 ( PAI 1 ) protein in the cytoplasm of transformed Escherichia coli cells results in inactive protein preparations that can be activated by denaturation and renaturation . ^^^ In addition , PAI 1 retains its capacity to form equimolar complexes with its target serine protease tissue type plasminogen activator ( t PA ) , as well as its ability to inhibit t PA activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Small differences are also observed in the abilities of these tcr variants to interact with the fast acting plasma inhibitor of uPA , viz . , plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We , therefore , performed immunohistological studies on human colon tumours using monoclonal antibodies against urokinase ( u PA ) and tissue type plasminogen activator ( t PA ) as well as against plasminogen activator inhibitors 1 and 2 ( PAI 1 , PAI 2 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
There were no differences in prevalence of CHD or levels of blood pressure , serum lipids , or plasminogen activator inhibitor 1 ( PAI 1 ) activity between the three ACE genotypes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To study a possible hypercoagulability in vascular disease , in 22 patients with essential hypertension and in 13 patients with obliterative arteriopathies of the lower limbs we measured the levels of plasma thrombomodulin ( TM ) , plasma and urine beta thromboglobulin ( beta TG ) , plasma D dimer ( DD ) and plasminogen activator inhibitor ( PAI 1 ) and compared to the values obtained from 10 healthy volunteers . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
On the contrary , uPAR bound complexes of uPA with its serpin inhibitors PAI 1 ( plasminogen activator inhibitor type 1 ) or PN 1 ( protease nexin 1 ) are readily internalized in several cell types . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This cell line synthesized prostacyclin , tissue type plasminogen activator ( tPA ) , and plasminogen activator inhibitor 1 ( PAI 1 ) as well as produced the proform of matrix metalloproteinase 1 , which was activated by cultivating the cells with plasminogen . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Kinetic analyses showed that anhydrotrypsin had little or no ability to compete with trypsin for binding to alpha 1 proteinase inhibitor ( alpha 1PI ) , plasminogen activator inhibitor 1 ( PAI 1 ) , antithrombin ( AT ) , or AT heparin complex when present at up to a 100 fold molar excess over trypsin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Synthesis of tissue plasminogen activator ( t PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) was higher in the control cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Methods used to assess the expression and levels of urokinase type plasminogen activator ( uPA ) or plasminogen activator inhibitor 1 ( PAI 1 ) have also been developed , and correlate with angiogenic activity and prognosis of patients with breast cancer . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To characterize the structural requirements for the conformational flexibility in plasminogen activator inhibitor 1 ( PAI 1 ) we have crystallized human PAI 1 , carrying a mutation which stabilizes PAI 1 in its substrate form . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Testosterone level was low and Plasminogen Activator Inhibitor ( PAI 1 ) was elevated . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Three major components of the plasminogen activators ( PA ) / plasmin system are synthesized physiologically in glomeruli , and can be involved in glomerular proteolysis and extracellular matrix metabolism : tissue type PA ( tPA ) , urokinase ( uPA ) and PA inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Blood levels of the clotting factor fibrinogen and tissue plasminogen activator inhibitor 1 ( PAI 1 ) , a primary inhibitor of fibrinolysis , have been positively linked to risk of coronary heart disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma platelet factor 4 ( PF 4 ) , fibrinopeptide A ( FPA ) , tissue plasminogen activator antigen ( t PA ) , and plasminogen activator inhibitor 1 activity ( PAI 1 ) were measured . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The present study compared the activities of recombinant tissue type plasminogen activator ( t PA ) and a plasminogen activator inhibitor 1 ( PAI 1 ) resistant variant t PA ( Kt PA , KHRR 296 299 AAAA ) in preventing renal fibrin deposition in rabbits with elevated PAI 1 activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the U 937 histiocytic cell line , we investigated the effect of calcium mobilizing agents with or without tumor necrosis factor alpha ( TNF ) on the regulation of the synthesis of plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In this cross sectional study we compared the abilities of lipoprotein ( a ) [ Lp ( a ) ] , plasminogen activator inhibitor 1 ( PAI 1 ) , and tissue plasminogen activator ( TPA ) to discriminate between individuals with and without a history of stroke from among subjects in a metabolic ward . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
An increase in levels of plasma plasminogen activator inhibitor type 1 ( PAI 1 ) is one of the main hemostatic alterations in patients with coronary heart disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Therefore , we evaluated whether thrombin affected the expression of endometrial stromal cell urokinase type ( uPA ) and tissue type ( tPA ) plasminogen activators and their primary inhibitor , type 1 plasminogen activator inhibitor ( PAI 1 ) , and whether ovarian steroids modulated putative thrombin effects . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Although elevated plasma plasminogen activator inhibitor 1 ( PAI 1 ) is associated with obesity , very little is known about its tissue or cellular origin , or about the events that lead to increased PAI 1 levels under obese conditions . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue plasminogen activator ( TPA ) , free plasminogen activator inhibitor 1 ( free PAI 1 ) , TPA / PAI 1 complex , and total PAI 1 antigen levels were measured before , at 1 week after , and at 3 months after PTCA . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The urokinase plasminogen activator ( u PA ) and its inhibitor ( PAI 1 ) in embryo fetal bone formation in the human : an immunohistochemical study . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The fasting values of serum lipids , plasminogen activator inhibitor ( PAI 1 ) activity , tissue plasminogen activator ( t PA ) antigen , and insulin sensitivity did not differ between Le ( a b ) men and men with other Lewis phenotypes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Hypofibrinolysis was identified as a deficiency of stimulated tissue plasminogen activator in 22 ( 45 % ) patients and elevated plasminogen activator inhibitor 1 ( PAI 1 ) in 29 ( 59 % ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) promoter polymorphism and coronary artery disease in non insulin dependent diabetes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma fibrinogen , thrombin antithrombin complex ( TAT ) , plasmin plasmin inhibitor complex , fibrin D dimer , activated protein C ( APC ) protein C inhibitor ( PCI ) complex , von Willebrand factor ( vWf ) , tissue plasminogen activator ( t PA ) , PA inhibitor 1 ( PAI 1 ) , and thrombomodulin levels in both PE and DVT patients were significantly increased compared with normal volunteers . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Then , in order to investigate the mechanisms of hyperfibrinolysis in liver cirrhosis , plasma levels of tissue type plasminogen activator ( t PA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) were determined in these patients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
No significant differences were found between the two groups for placental procoagulant tissue factor and anticoagulant thrombomodulin activities , and for the content in plasminogen activators and PAI 1 antigens . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The 4G / 5G genetic polymorphism in the promoter of the plasminogen activator inhibitor 1 ( PAI 1 ) gene is associated with differences in plasma PAI 1 activity but not with risk of myocardial infarction in the ECTIM study . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In Paris , France , clinicians compared data on 64 women aged 19 40 who used combined oral contraceptives ( OCs ) for 6 200 months with data on 64 healthy women who did not use OCs for the last two months and who were matched for age and smoking status to investigate activity of plasminogen activator inhibitor 1 ( PAI 1 ) , factor 7 antigen , fibrinogen concentration , and antithrombin activity in users of OCs containing either 30 mcg or 50 mcg estrogen and in nonusers . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have recently shown that plasminogen activator inhibitor 1 ( PAI 1 ) mRNA is elevated after hemorrhage in various tissues including liver . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
It was found that cadmium markedly decreased the release of both tissue plasminogen activator antigen ( t PA : Ag ) and plasminogen activator inhibitor type 1 antigen ( PAI 1 : Ag ) from vascular smooth muscle cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Type 1 plasminogen activator inhibitor ( PAI 1 ) is known to be synthesized in an active conformation but it is rapidly converted into an inactive conformation ( t1 / 2 1 h ) upon incubation at 37 degrees C . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Upon transfection , wild type T beta R 1 restored the TGF beta signals for growth inhibition and production of plasminogen activator inhibitor 1 ( PAI 1 ) and fibronectin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS AND RESULTS : Enzyme immunoassays ( EIAs ) showed that urokinase and tissue plasminogen activators ( uPA , tPA ) and PA inhibitors ( PAI 1 , PAI 2 ) were present in ascites from both patient groups and that tPA was the predominant PA . uPA , tPA , and PAI 1 , were detected in plasma from patients and controls . ^^^ Plasma from the liver disease patients showed a higher tPA / PAI 1 ratio and , thus a higher potential for plasminogen activation than plasma from cancer patients and controls . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) in plasma : its role in thrombotic disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In order to establish a link between cytokines and the hemostatic changes the following parameters were determined in 44 patients with cirrhosis ( alcoholic = 15 , postnecrotic = 22 , others = 7 ) : TNF alpha , IL 6 , thrombin antithrombin ( TAT ) complexes , prothrombin fragment 1 + 2 ( F 1 + 2 ) and t PA by using enzyme linked immunosorbent assays , and PAI 1 , plasminogen and alpha 2 antiplasmin ( alpha 2 AP ) by using chromogenic substrates . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
After assay of accumulated release of tissue type plasminogen activator ( t PA ) and endothelin 1 ( ET ) , cells were stimulated with 1 U / ml of human thrombin for 1 h and medium collected for RIA of 6 keto prostaglandin F 1 alpha ( 6 keto PGF 1 alpha ) , thrombospondin ( TSP ) , von Willebrand factor ( vWf ) and ELISA of plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) levels are elevated in obese insulin resistant subjects . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Within 5 days , smooth muscle cells ( SMCs ) on the luminal surface expressed the mRNA for tissue type plasminogen activator ( TPA ) , urokinase type plasminogen ( UPA ) , the receptor for UPA ( UPAR ) , and plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This study examined the effects of tumor necrosis factor alpha ( TNF alpha ) and plasminogen on collagenase , stromelysin , and plasminogen activator inhibitor 1 ( PAI 1 ) synthesis of collagenase and stromelysin , which remained predominantly in proenzyme forms , as determined by Western analysis of culture media . ^^^ TNF alpha reduced plasminogen induced activation of MMPs , suggesting induction of an inhibitor or plasmin generation , such as PAI 1 . ^^^ Surprisingly plasminogen also increased PAI 1 secretion by vascular SMCs ( 3 . 6 fold over control ) . ^^^ In addition , the induction of PAI 1 by TNF alpha and plasminogen suggests a negative feedback mechanisms limit both plasmin mediated and MMP mediated matrix degradation . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is an important regulator of plasminogen activators and has been shown to be involved in the accumulation of extracellular matrix ( ECM ) in various tissues . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The present study was undertaken in order to determine the recognition site for tissue type plasminogen activator plasminogen activator inhibitor type 1 [ t PA PAI 1 ] complexes in rat liver in vivo and in vitro . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Three enzyme linked immunosorbent assays for the quantitation of murine tissue type plasminogen activator ( t PA ) , urokinase type plasminogen activator ( u PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) , were developed using monoclonal antibodies raised against the autologous proteins in gene inactivated mice . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Type 1 and type 2 plasminogen activator inhibitors ( PAI 1 and PAI 2 , respectively ) are known to mediate thrombosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
HB EGF enhanced the mRNA expression of tissue type plasminogen activator ( t PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) mRNA . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We investigated the effect of exogenous staphylococcal sphingomyelinase ( SMase ) on the release of tissue type plasminogen activator ( t PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) from cultured human umbilical vein endothelial cells ( HUVEC ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The balance of proteases and inhibitors differed dramatically from that observed in plasma , with higher levels of t PA , PAI 1 and PAI 2 , and lower levels of u PA ( urokinase ) , plasminogen , alpha 2 AP and t PA PAI 1 complex in bone marrow , and resulted in favourable conditions for fibrinolysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The urokinase type plasminogen activator ( u PA ) and the plasminogen activator inhibitor 1 ( PAI 1 ) are among the best second generation prognostic tissue factors in breast cancer . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The current study indicates that plasminogen activator activity of scuPA bound to recombinant , soluble uPAR ( suPAR ) is also fivefold less sensitive to inhibition by plasminogen activator type 1 ( PAI 1 ) than is soluble or receptor bound tcuPA . ^^^ Binding of PaI 1 to suPAR / scuPA complexes is totally reversible and can be overcome by increasing the concentration of plasminogen , suggesting a competitive mechanism of inhibition ( Ki = 18 nmol / L ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In an animal model of bleomycin induced lung fibrosis , increased expression of type 1 plasminogen activator inhibitor ( PAI 1 ) is associated with accumulation of fibrin in fibroproliferative lesions . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Using an adult pseudopregnant rat model , we have studied how two components of the PA system , tissue type plasminogen activator ( tPA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) , are expressed temporally and spatially during different developmental stages of the corpus luteum ( CL ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Active plasminogen activator inhibitor 1 ( PAI 1 ) , but not inactivated PAI 1 , inhibited VN binding to cells and displaced VN that was prebound to endothelial cell monolayers . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Serial blood samples were obtained via femoral venous catheters for tissue plasminogen activator ( tPA ) , plasminogen activator inhibitor ( PAI 1 ) , tPA PAI 1 complex ( tPA PAI ) , and euglobulin lysis time ( ELT ) from all subjects and for fibrin degradation products ( FbDP ) and fibrinogen degradation products ( FgDP ) from phase 2 subjects . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To test the hypothesis that DHEA might exert its effects by enhancing endogenous fibrinolytic potential , a double blind , placebo controlled study was conducted that assessed the effects of DHEA administration on plasma plasminogen activator inhibitor type 1 ( PAI 1 ) and tissue plasminogen activator ( tPA ) antigen . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In order to determine possible overexpression of cathepsin D and PAI 1 ( plasminogen activator inhibitor ) in head and neck tumours , cytosols from 92 primary squamous cell carcinomas ( SCC ) , 19 lymph node metastases and 24 adjacent normal tissue samples were examined . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
It was found that urokinase type plasminogen activator ( uPA ) , its receptor ( uPAR ) and plasminogen activator inhibitor type 1 ( PAI 1 ) were expressed diffusely in most thyroid carcinomas . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Complex regulation of plasminogen activator inhibitor type 1 ( PAI 1 ) gene expression by serum and substrate adhesion . ^^^ Expression of plasminogen activator inhibitor type 1 ( PAI 1 ) , a member of the serine protease inhibitor ( SERPIN ) superfamily that functions to negatively regulate the plasmin based pericellular proteolytic cascade , was induced early after exposure of growth arrested normal rat kidney ( NRK ) cells to serum containing medium . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : Obesity is known to predispose to attenuated fibrinolysis attributable to increased concentrations in plasma of type 1 plasminogen activator inhibitor ( PAI 1 ) , the primary physiological inhibitor of endogenous fibrinolysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
TGF beta 1 increases fibronectin expression and urokinase plasminogen activator ( uPA ) activity and plasminogen activator inhibitor 1 ( PAI 1 ) levels in 3D cultures . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The cellular distribution of mRNAS for urokinase type plasminogen activator ( uPA ) , its specific receptor ( uPAR ) , and its inhibitors ( PAI 1 and 2 ) in mouse skin was analyzed by in situ hybridization after topical application of the tumor promoter phorbol 12 myristate 13 acetate . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fibrin gel degradation occurred through plasmin mediated fibrinolysis , which was initiated by fibroblasts exhibited high uPA but low plasminogen activator inhibitor 1 ( PAI 1 ) activities , and transforming growth factor beta 1 prevented fibrinolysis of normal fibroblasts by upregulating PAI 1 while downregulating uPA activities . ^^^ In terms of the pivotal role of the plasmin / plasminogen activator system in matrix remodeling , the elevated PAI 1 level exhibited by keloid fibroblasts may have significant consequences not only in altered fibrin degradation , but also in subsequent repair steps that lead to keloids and fibrosis . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
However , single deficient mice lacking tissue type plasminogen activator ( tPA ) , urokinase type plasminogen activator ( uPA ) , or PA inhibitor type 1 ( PAI 1 ) gene function were recently found to have normal reproduction , although mice with a combined deficiency of tPA and uPA were significantly less fertile . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Furthermore both HA and SHA stimulated HUVEC to produce plasminogen activator inhibitor ( PAI 1 ) and tissue plasminogen activator ( t PA ) in a dose and time dependent fashion ; the amount of PAI 1 produced was found to exceed that of t PA . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is a member of the serpin superfamily of proteins and is the fast acting inhibitor of both urinary plasminogen activator and tissue type plasminogen activator . ^^^ Using site directed mutagenesis , the P1 ' P 5 ' residues ( P 1 ' is the first residue on the carboxy terminal side of the protease cleavage site ) of the wild type PAI 1 reactive center sequence were replaced with the corresponding sequences of plasminogen activator inhibitor 2 , antithrombin , alpha 2 antiplasmin and protease nexin 1 . ^^^ The results suggest a crucial role for both reactive center length and sequence in the inhibition of plasminogen activators by PAI 1 . ^^^ Apparently , the determinants of the rapid inhibitory specificity of PAI 1 are localized to the P1 ' P 5 ' region of the reactive center and these residues act synergistically to produce the exquisite specificity of PAI 1 for plasminogen activators . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The concentrations of urokinase plasminogen activator ( uPA ) , tissue type plasminogen activator ( tPA ) , plasminogen activator inhibitor 1 ( PAI 1 ) and interleukin 1beta were all found to be significantly different in interfaces and in pseudocapsules , compared to controls . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Prognostic relevance of urokinase type plasminogen activator ( uPA ) and plasminogen activator inhibitors PAI 1 and PAI 2 in gastric cancer . ^^^ Expression of urokinase type plasminogen activator ( uPA ) , plasminogen activator inhibitor 1 ( PAI 1 ) and plasminogen activator inhibitor 2 ( PAI 2 ) was evaluated in 125 surgically resected gastric cancers by immunohistochemical analysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The patients had clearly disturbed fibrinolytic function , with elevated plasminogen activator inhibitor 1 ( PAI 1 ) activity at rest ( approximately 25 U / mL ; reference , < 15 U / mL ) . ^^^ Plasma levels of PAI 1 activity and tissue type plasminogen activator ( TPA ) activity or antigen were unaffected by gemfibrozil treatment both at rest and during the provocations . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The concentration of plasminogen activator inhibitor 1 ( PAI 1 ) increased significantly during the progression from normal vessels to fatty streaks to the developed atherosclerotic plaque . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To evaluate the role of plasminogen activators ( tPA uPA ) and inhibitor ( PAI 1 ) in the pathogenesis of preeclampsia . ^^^ CONCLUSIONS : The elevated PAI 1 level is associated with the preeclampsia and the imbalance between the plasminogen activators ( tPA , uPA ) and the inhibitor ( PAI 1 ) might be involved in the pathogenesis of preeclampsia . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Cysteine proteases ( cathepsin B [ CATB ] and cathepsin L [ CATL ] ) , the serine protease urokinase type plasminogen activator ( UPA ) , and plasminogen activator inhibitor type 1 ( PAI 1 ) are thought to play an important part in cancer invasion and metastasis . ^^^ Urokinase type plasminogen activator , PAI 1 and CATB levels had a significant prognostic impact . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activation was assessed by measuring the plasmin activity and plasminogen activator inhibitor 1 ( PAI 1 ) levels in cell conditioned media and the cell associated urokinase type plasminogen activator ( uPA ) levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Its regulation is largely mediated by interaction with a host of inhibitors including antithrombin 3 ( ATIII ) , heparin cofactor 2 ( HCII ) , alpha 2 macroglobulin ( alpha 2 M ) , protease nexin 1 , and plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Treatment of the cells with interleukin ( IL ) beta or tumor necrosis factor alpha ( TNFalpha ) under static conditions had no effect on tissue plasminogen activator ( t PA ) secretion , while release of plasminogen activator inhibitor 1 ( PAI 1 ) increased . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The effect of chronic stress on tissue type plasminogen activator ( TPA ) and plasminogen activator inhibitor 1 ( PAI 1 ) antigens was studied in 69 healthy middle aged men . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
They also had significantly ( P < . 05 ) higher plasma fibrinogen , factor 8 clotting activity , tissue type plasminogen activator antigen , and plasminogen activator inhibitor 1 ( PAI 1 ) activity ( 19 . 2+ / 2 . 4 versus 8 . 5+ / 1 . 6 AU / mL , P < . 001 ) and lower basal tissue type plasminogen activator activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This study assessed the short and long term effects of an energy restrictive diet with or without exercise on plasminogen activator inhibitor 1 antigen ( PAI 1 Ag ) and PAI 1 activity , tissue type plasminogen activator antigen ( TPA Ag ) , and fibrinogen serum levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Phage display technology has been exploited to study in detail the interaction between plasminogen activator inhibitor 1 ( PAI 1 ) and either thrombin or an essential positively charged `` loop ' ' of tissue type plasminogen activator ( t PA ) , denoted variable region 1 ( VR 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Elevated plasma levels of plasminogen activator inhibitor 1 ( PAI 1 ) have been shown to be a risk factor for the development of vascular complications in obese and hyperinsulinemic non insulin dependent diabetes ( NIDDM ) patients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
RESULTS : Univariate analysis showed that a low tissue type plasminogen activator ( t PA ) activity in normal mucosa and in carcinomas and a high antigen level of inhibitor type 1 ( PAI 1 ) , and , to a lesser extent , of urokinase type plasminogen activator ( u PA ) receptor , in carcinomas are associated with a poor overall survival of the patients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : A strong positive correlation exists between the breast cancer tissue content of either urokinase plasminogen activator ( uPA ) or plasminogen activator , inhibitor type 1 ( PAI 1 ) , quantified in the tissue extracts by immunoassays , and the survival of patients with breast cancer . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The expression of tissue type plasminogen activator ( t PA ) , urokinase type PA ( u PA ) and PA inhibitor 1 ( PAI 1 ) in such treated cells was investigated by specific ELISAs on the protein level and by Northern blotting on the mRNA level . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have investigated the localization of urokinase type plasminogen activator ( u PA ) , type 1 plasminogen activator inhibitor ( PAI 1 ) , u PA receptor ( u PAR ) and alpha ( 2 ) macroglobulin receptor / low density lipoprotein receptor related protein ( alpha ( 2 ) MR / LRP ) in human breast tumors by immunohistochemical methods . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Platelets have been regarded as the main source of plasminogen activator inhibitor 1 ( PAI 1 ) found in occlusive platelet rich clots . ^^^ We will show that , in vitro , tumor necrosis factor alpha stimulated endothelial cells secrete large amounts of PAI 1 over a period of hours , which then binds to fibrin and protects the clot from tissue plasminogen activator induced fibrinolysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) , a rapid inhibitor of both uPA and tissue type plasminogen activator ( tPA ) is the major physiologic regulator of plasminogen activator activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS AND RESULTS : We investigated the relation of current use of replacement hormones to three measures of plasma fibrinolytic activity : tissue type plasminogen activator ( TPA ) antigen , plasminogen activator inhibitor 1 ( PAI 1 ) antigen , and D dimer . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We examined mRNA expressions of urokinase type plasminogen activator ( u PA ) , its specific receptor ( u PR ) , and plasminogen activator inhibitors ( PAI 1 and PAI 2 ) in 50 human breast cancers by the reverse transcriptase polymerase chain reaction method . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma levels of tissue plasminogen activator ( t PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) in a resting and venous occluded state were measured . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fluctuations in tissue plasminogen activator ( t PA ) activity , t PA antigen , and plasminogen activator inhibitor 1 ( PAI 1 ) antigen levels were evaluated in blood samples obtained from 84 patients with initial uneventful acute myocardial infarction ( AMI ) and 35 patients with reinfarction and fatal infarction ( patients with bad prognoses ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The anti TGF beta IIR NT antibodies also blocked the TGF beta dependent induction of the plasminogen activator inhibitor ( PAI 1 ) promoter observed in mink lung epithelial cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We tested whether the physiological inhibitors of urokinase , plasminogen activator inhibitor 1 and 2 ( PAI 1 , PAI 2 ) , could regulate the activity of spirochete bound urokinase . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Median levels of fibrinogen ( P < 0 . 0001 ) , thrombin antithrombin 3 complex ( TAT ) ( P < 0 . 005 ) , and plasminogen activator inhibitor 1 ( PAI 1 ) activity ( P < 0 . 05 ) in plasma were significantly elevated in diabetic patients compared with controls . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Activity of plasminogen activator inhibitor ( PAI 1 ) in plasma of women treated after menopause with hormone replacement therapy ] . ^^^ Plasma activity of plasminogen activator inhibitor ( PAI 1 ) , levels of fibrinogen and serum lipids profile was measured before , after 6 and 12 months of continuous treatment . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Since the possible variation of tissue type plasminogen activator ( TPA ) antigen and plasminogen activator inhibitor 1 ( PAI 1 ) antigen concentrations over time after stroke has been rarely studied , it was examined in plasma from stroke patients in the acute and convalescent phases of the disease and in a control group . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Increased levels of plasma fibrinogen ( FBG ) , coagulation factor 7 ( FVII ) , tissue plasminogen activator ( t PA ) , and plasminogen activator inhibitor 1 ( PAI 1 ) as well as hyperlipidemia are regarded as important risk factors for CVD . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is a unique member of the serpin superfamily . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Type 1 plasminogen activator inhibitor ( PAI 1 ) and its cofactor vitronectin ( Vn ) are stored within the alpha granules of platelets . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : Plasminogen activator inhibitor 1 ( PAI 1 ) , an important regulator of fibrinolysis and extracellular matrix turnover , has been implicated in a number of vascular diseases . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
These clinical studies indicate that overexpression of factors associated with the invasion of gastric cancer cells through the basement membrane , including E cadherin , MMP 2 , plasminogen activator inhibitor 1 ( PAI 1 ) , and tissue inhibitor metalloproteinase 2 ( TIMP 2 ) , can be predictive of tumor recurrence and overall survival in patients with this disease . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) binds to the somatomedin B ( SMB ) domain of vitronectin ( VN ) , a domain present in at least seven other proteins . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Mitogen activated protein ( MAP ) kinase phosphatase 1 and a dominant negative MAP / ERK kinase 1 mutant reduced stimulation of plasminogen activator inhibitor 1 ( PAI 1 ) promoter activity by TGF beta 1 from 11 . 5 to 4 fold and 4 . 9 fold , respectively . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We report here that n butyrate can increase substantially the level of plasminogen activator inhibitor type 1 ( PAI 1 ) messenger RNA ( mRNA ) in Hep G 2 cells , up to eightfold above control cultures . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
PURPOSE : Plasminogen activator inhibitor type 1 ( PAI 1 ) inhibits the plasminogen activators that convert plasminogen to plasmin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A possible cause of accelerated atherothrombosis in the syndrome of insulin resistance appears to be an elevated blood concentration of plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^ Initially elevated PAI 1 concentrations decreased by 50 % , with a simultaneous decrease in the concentration of tissue type plasminogen activator ( t PA ) / PAI 1 complexes but no significant change in t PA suggested a decrease in inhibition of the fibrinolytic system . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A 5 . 4 kb cDNA encoding the protein that binds to the B Box of the plasminogen activator inhibitor 1 ( PAI 1 ) gene was isolated and sequenced . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The role of fat accumulation and its effect on plasminogen activator inhibitor 1 ( PAI 1 ) levels was investigated in humans and animals . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We analyzed the expression of plasminogen activator inhibitor 1 ( PAI 1 ) in 16 leiomyomas and adjacent myometrium of women who underwent a hysterectomy while in the proliferative ( n = 8 ) and secretory phases ( n = 8 ) of the menstrual cycle . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor type 1 ( PAI 1 ) is undetectable in cells of some aggressive malignancies , but present in the stroma of tumor associated microvasculature . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The plasma level of plasminogen activator inhibitor 1 antigen ( PAI 1 ) was transiently increased 15 min after the start of bathing and returned to the pre bathing level 360 min later . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Glycosylated human plasminogen activator inhibitor type 1 ( PAI 1 ) , produced in Chinese hamster ovary ( CHO ) cells , showed a variety of compounds with different molecular weights when subjected to electrospray mass spectrometry ( ES MS ) , owing to the heterogeneity of the carbohydrate chains . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We obtained that the fibrinogen , tissue plasminogen activator ( tPA ) and plasminogen activator inhibitor ( PAI 1 ) levels are significantly increased ( p < 0 . 01 ) in the group of patients , and in the same way , there are also differences ( p < 0 . 01 ) between men and women , so in the control group as in the patients group ; these differences should mean that women have a major risk for suffering an stroke , but it does n ' t fits the fact that stroke is more frequent in men and that they are younger when they suffer from this disease . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma levels of tissue plasminogen activator antigen ( t PA : Ag ) , plasminogen activator inhibitor type 1 antigen ( PAI 1 : Ag ) and PAI 1 activity , fibrin plate , von Willebrand factor antigen ( vWF : Ag ) , tissue factor ( TF ) and soluble thrombomodulin ( sTM ) were measured . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In experimental models , plasminogen activator mediated degradation of the extracellular matrix is inhibited by type 1 plasminogen activator inhibitor ( PAI 1 ) . ^^^ Immunohistochemical analysis showed that PAI 1 antigen was primarily confined to tumour cells and vascular endothelium , a distribution similar to that previously reported for plasminogen activator activity in RCC . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The plasminogen activators ( PA ) , which are regulated by their specific inhibitor , PAI 1 , convert the zymogen plasminogen to plasmin , a protease involved in fibrinolysis and extracellular matrix turnover . ^^^ We investigated the effects of IL 1 on the production of tissue type plasminogen activator ( t PA ) , urokinase ( u PA ) and PAI 1 by glomerular cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
They aimed to examine the effect of proinsulin and insulin on fasting secretion of plasminogen activator inhibitor type 1 ( PAI 1 ) and tissue plasminogen activator ( t PA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Stearic fat resulted in a tendency toward lower activity of plasminogen activator inhibitor 1 ( PAI 1 ) than did myristic fat ( P < 0 . 08 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In breast cancer , receptor bound urokinase type plasminogen activator ( uPA ) and its inhibitor PAI 1 seem to play an important role in the dissolution of the surrounding tissue and the formation of tumour stroma . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
At the time of re evaluation , serum triglyceride , fibrinogen , and plasminogen activator inhibitor type 1 ( PAI 1 ) levels were lower and high density lipoprotein ( HDL ) cholesterol levels were higher in the bezafibrate group than in group C . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue plasminogen activator ( t PA ) , plasminogen activator inhibitor 1 ( PAI 1 ) , and thrombomodulin were also measured . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma levels of selected coagulation and fibrinolytic parameters ( activated partial thromboplastin time , prothrombin time , fibrinogen , antithrombin 3 , protein C , thrombin anti thrombin 3 complexes ( TAT ) , plasminogen activator inhibitor 1 ( PAI 1 ) , plasminogen , alpha 2 plasmin inhibitor ) were evaluated in 90 patients with clinical suspicion of pulmonary embolism ( PE ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The hypothesis that tea drinking may protect against coronary heart disease ( CHD ) through effects on clotting as measured by plasma fibrinogen , tissue type plasminogen activator ( tPA ) and plasminogen activator inhibitor 1 ( PAI 1 ) was tested in 65 healthy volunteers ( 31 men and 34 women ; aged 20 74 years ) in a randomized , blind , placebo controlled , crossover study lasting 10 weeks ( run in phase 2 weeks , tea and placebo phases 4 weeks ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fibrinogen , factor 7 ( FVII ) , factor 8 : C ( FVIII : C ) , antithrombin 3 ( ATIII ) , protein C , protein S , heparin cofactor 2 ( HCII ) and plasminogen activator inhibitor ( PAI 1 ) levels were measured at baseline and after 6 and 12 cycles . 167 women who took the treatment for at least 6 cycles were evaluable . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor type 1 ( PAI 1 ) is a fast acting inhibitor of plasminogen activators ( PAs ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The plasminogen and plasmin system , which is mainly regulated by urokinase type plasminogen activator ( uPA ) , its receptor ( uPAR ) and its inhibitor ( PAI 1 ) , is generally believed to play a role in cancer invasion and metastasis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Sequential analyses in a control group with active PTB showed anaemia , thrombocytosis , elevations in plasma fibrinogen , fibrin ( ogen ) degradation products ( FDP ) , tissue plasminogen activator ( t PA ) and inhibitor ( PAI 1 ) with depressed antithrombin 3 levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Injection of plasminogen induced a variable increase ( on average 7 to 10 fold ) of PAI 1 , but no correlation with the extent of spontaneous clot lysis was observed . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Young and senescent cells were compared in quiescent and activated growth conditions for the secretion of tissue type plasminogen activator ( t PA ) , urokinase type plasminogen activator ( u PA ) , plasminogen activator inhibitor 1 ( PAI 1 ) and plasminogen activator inhibitor 2 ( PAI 2 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : Under carefully controlled conditions , fasting blood was drawn from 19 healthy control subjects , 10 patients with PRP , 17 with lcSSc and nine with dSSc for measurement of the following : von Willebrand factor ( VWF ) and soluble thrombomodulin as markers of endothelial damage / activation , thromboxane ( as thromboxane B 2 ) and beta thromboglobulin as markers of platelet activation , and tissue plasminogen activator antigen , tissue plasminogen activator activity and plasminogen activator inhibitor 1 ( PAI 1 ) as markers of fibrinolysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Unfavourable changes in a series of variables held independent risk factors for the development of vascular lesions ( HDL cholesterol , haematocrit , white blood cell count , fibrinogen and plasminogen activator inhibitor 1 ( PAI 1 ) ) are thought to be directly influenced by cigarette smoking . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Simultaneously , plasma levels of the inhibitor of plasminogen activation , PAI 1 , sharply increased . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The aim of this study was to investigate the anti thrombotic effects of an inhibitor of the plasminogen activator inhibitor 1 ( PAI 1 ) in rats given endotoxin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The proteins of fibrinolysis have been quantified in human thrombi , to assess the balance between plasminogen activators and their major inhibitor PAI 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This occurs because of the short half life of rt PA and rapid increase in plasminogen activator inhibitor ( PAI 1 ) and alpha 2 antiplasmin levels in plasma . ^^^ PAI 1 and alpha 2 antiplasmin plasma levels were suppressed in all dogs receiving lys plasminogen whether it was given before or after rt PA . ^^^ In contrast , lys plasminogen given after rt PA does not influence the thrombolytic effect of rt PA , whereas it suppresses PAI 1 and alpha 2 antiplasmin levels in plasma . ^^^ This study also suggests that binding of plasminogen to the clot is more important than the plasma levels of PAI 1 and alpha 2 antiplasmin . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Venous blood samples were taken at each visit for plasma glucose and insulin , HbA1c , triglyceride and cholesterol , plasminogen activator inhibitor 1 ( PAI 1 ) antigen and activity , tissue plasminogen activator ( tPA ) , and euglobulin clot lysis time ( ECLT ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : By contributing to a prothrombotic state , increased levels of plasminogen activator inhibitor 1 ( PAI 1 ) may be involved in the pathogenesis of the vascular complications of non insulin dependent diabetes mellitus ( NIDDM ) . ^^^ RESEARCH DESIGN AND METHODS : A total of 135 Caucasian NIDDM subjects treated with oral therapy or diet alone were classified by the presence or absence of retinopathy , and fasting blood samples were taken for assay of PAI 1 antigen and activity , tissue plasminogen activator ( t PA ) , t PA complexed with PAI 1 , euglobulin clot lysis time ( a measure of overall fibrinolytic activity ) , glucose , HbA1c , cholesterol , triglyceride , and insulin levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A critical component in the regulation of thrombus formation and clearance is the balance between tissue plasminogen activator ( tPA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
On postnatal day 1 there were differences between plasminogen activator inhibitor 1 ( PAI 1 ) activity and antigen , of both full term and preterm infants with and without IVH ( P < 0 . 05 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma plasminogen activator inhibitor type 1 ( PAI 1 ) and tissue plasminogen activator ( tPA ) antigens and activities were measured in 28 patients with hypertension and 12 normal controls . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor ( PAI 1 ) activity is elevated in Asian and Caucasian subjects with non insulin dependent ( type 2 ) diabetes but not in those with impaired glucose tolerance ( IGT ) or non diabetic Asians . ^^^ In order to study the plasminogen activator inhibitor activity ( PAI 1 ) in subjects at different risk of non insulin dependent diabetes and ischaemic heart disease we examined 89 subjects with diet controlled NIDDM ( 49 Caucasian , 40 Asian ) , 29 with impaired glucose tolerance ( IGT ) ( 13 Caucasian , 16 Asian ) , and 149 with normal glucose tolerance ( 67 Caucasian , 82 Asian ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
O . ) and plasminogen activator inhibitor type 1 ( PAI 1 ) activity were taken at 6 months after the first episode of VTE or the first recurrent VTE in 784 and 207 patients , respectively , who were anticoagulated for 1 . 5 or 6 months ( first VTE ) and 6 months or indefinitely ( first recurrence ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
When compared with the control groups circulating tissue type plasminogen activator antigen , and especially plasminogen activator inhibitor type 1 , PAI 1 antigen and activity were significantly increased , the mean increase ranging between 54 % and 140 % in the bypass group . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This study was performed to test the hypothesis that ECs inhibit transforming growth factor beta 2 ( TGF beta 1 ) activation through the release of plasminogen activator inhibitor ( PAI 1 ) . ^^^ CONCLUSIONS : In a model designed to study SMC / EC interactions , it was seen that ECs can alter growth characteristics of SMCs by producing PAI 1 , which interferes with the plasminogen pathway of TGF beta 1 activation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
After a delay of 90 min , plasminogen activator inhibitor 1 ( PAI 1 ) antigen rose to high levels in the r TNF alpha treated group ( mean maximum PAI 1 , 1652 ng / ml versus 211 ng / ml in controls ; P < 0 . 02 ) , associated with a sharp decrease of tissue plasminogen activator activity and a slower decrease of plasminogen antiplasminogen complexes ( from 5 . 28 to 0 . 02 IU / ml in 2 h and from 1573 to 347 micrograms / liter in 22 h , respectively ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) ] . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Each mutant clone retains all three TGFbeta receptors yet fails to induce a TGFbeta inducible luciferase reporter construct or TGFbeta mediated plasminogen activator inhibitor 1 ( PAI 1 ) expression . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In 30 patients with prostatic carcinoma a higher of t PA , a low of PAI 1 , alpha 2 antiplasmin and plasminogen activity with increased fibrin degradation products ( FDP ) level and a short euglobulin lysis time ( ELT ) were observed . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
MAIN RESULTS : Discriminant analysis suggested that smokers , compared with non smokers , were characterised by a higher alcohol energy percent , lower HDL cholesterol concentration , lower systolic blood pressure , and a higher plasminogen activator inhibitor 1 ( PAI 1 ) value . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Upon activation with cytokines or other stimuli , EC up regulate a number of genes , including E selectin ( ELAM 1 ) , intercellular adhesion molecule ( ICAM ) 1 , vascular cell adhesion molecule ( VCAM ) 1 , interleukin ( IL ) 1 , IL 8 , tissue factor ( TF ) , plasminogen activator inhibitor 1 ( PAI 1 ) , MCP 1 ( monocyte chemoattractant protein 1 ) and endothelial cell inducible gene ( ECI 6 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Cyclic strain induced plasminogen activator inhibitor 1 ( PAI 1 ) release from endothelial cells involves reactive oxygen species . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the in vitro clot lysis system , with use of clots prepared from fresh frozen human plasma , r ProUK exhibits a lag phase to the onset of lysis and a concentration dependent threshold effect due to the presence of the inhibitors alpha 2 antiplasmin and plasminogen activator inhibitor ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Similarly , D dimer was over four fold ( p = 0 . 0001 ) , while tissue plasminogen activator and plasminogen activator inhibitor 1 ( PAI 1 ) antigens were about two fold ( p = 0 . 02 and p < 0 . 003 , respectively ) higher than in PAOD . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) was identified in polymorphs from normal individuals and levels rose significantly in polymorphs from septic patients : neutrophils from normal subjects did not contain PAI 2 but this protein was detectable in significant quantities in polymorph preparations from septic patients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To identify potential factors that may contribute to this problem , we characterized elaboration by human brain endothelial cells of plasminogen activator inhibitor 1 ( PAI 1 ) and measured PAI 1 mRNA levels . ^^^ METHODS AND RESULTS : When human cerebral microvascular endothelial cells ( HCMEC ) , pial arterial endothelial cells , and middle meningeal arterial endothelial cells were exposed to 10 to 1000 ng / mL recombinant tissue type plasminogen activator ( RTPA ) , urokinase type plasminogen activator ( UPA ) , or streptokinase / plasminogen ( 37 U streptokinase plus 2 mumol / L plasminogen ) for 24 hours , they exhibited concentration dependent decreases in elaboration of PAI 1 of 65 + / 3 % , 48 + / 3 % , and 59 + / 8 % . ^^^ UPA and streptokinase / plasminogen elicited decreases of 33 + / 8 % and 35 + / 4 % , respectively , that were specific with respect to the protease agonists as to total protein synthesis and cell type ; ie , neither human umbilical vein endothelial cells nor cerebral pericytes exhibited inhibition of PAI 1 elaboration . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In this study , the effects of ET 1 on fibrinolysis , plasminogen activator inhibitor 1 ( PAI 1 ) synthesis and PAI 1 mRNA expression were examined in cultured rat mesangial cells ( MCs ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : Previous studies have reported decreased intrinsic fribrinolytic activity increased systemic plasminogen activator inhibitor 1 ( PAI 1 ) activity and / or decreased systemic tissue plasminogen activator ( t PA ) activity in patients with acute myocardial infarction . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND & AIMS : Plasminogen activator inhibitor type 1 ( PAI 1 ) plays a crucial role in the regulation of extracellular matrix degrading enzymes and in the production of fibrogenic mediators such as transforming growth factor beta through inhibition of plasminogen activation . ^^^ Transforming growth factor beta 1 , tissue plasminogen activator , and dexamethasone increased PAI 1 production in HSCs . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Compared with men , women at baseline had similar rhythms for tissue plasminogen activator ( t PA ) activity and plasminogen activator inhibitor 1 ( PAI 1 ) activity , but lower levels of total t PA antigen . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
An immunohistological analysis revealed the presence of plasminogen activator inhibitor type 1 ( PAI 1 ) in the basement membrane as well as in the interior of the tubules . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) , a possible risk parameter for thromboembolism , was significantly more increased postoperatively in the control group , which received only homologous blood . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
RESULTS : A marked increase in the expression of tissue factor ( TF ) and type 1 plasminogen activator inhibitor ( PAI 1 ) and an inhibition of tissue type and urokinase type plasminogen activators ( tPA and uPA , respectively ) , matrix metalloproteinases ( MMP ) , and endothelin 1 ( ET 1 ) expression accompany progestin induced decidualization of estrogen primed endometrial stromal cells both in vivo and in vitro . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The plasminogen activator ( PA ) / plasmin system has been extensively investigated in these processes , and descriptive studies have demonstrated that urokinase type PA ( uPA ) , uPA receptor ( uPAR ) and PA inhibitor 1 ( PAI 1 ) are expressed by endothelial cells during angiogenesis in vivo . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The sites of synthesis of urokinase type plasminogen activator ( uPA ) , uPA receptor ( uPAR ) , plasminogen activator inhibitor type 1 ( PAI 1 ) and alpha 2 macroglobulin receptor / low density lipoprotein receptor related protein ( alpha 2MR / LRP ) transcripts were determined by in situ hybridization . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
High level expression of active human plasminogen activator inhibitor type 1 ( PAI 1 ) in E . coli . ^^^ Plasminogen activator inhibitor 1 ( PAI 1 ) is an important regulator of plasminogen activation , which inhibits both tissue type plasminogen activator ( tPA ) and urokinase type plasminogen activator ( uPA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To characterize the vasospastic angina patients with exercise induced ischemia , we measured hemostasis ( platelet factor 4 ; PF 4 , fibrinopeptide A ; FPA ) and fibrinolytic parameters ( tissue plasminogen activator antigen ; t PA , free plasminogen activator inhibitor 1 antigen ; free PAI 1 ) in 15 normal subjects and 33 vasospastic angina patients without significant coronary artery stenosis ( less than 50 % stenosis ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Synthesis of plasminogen activator inhibitor type 1 ( PAI 1 ) by the endothelium may protect these cells and the subendothelial cell matrix from excessive degradation and retard leukocyte migration . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Expression of plasminogen activator inhibitor type 1 ( PAI 1 ) , a serine protease inhibitor and member of the serpin gene family which is synthesized by `` activated ' ' or migrating keratinocytes in vivo , was restricted to the preconfluent stages of cell growth in vitro , a condition equivalent to wound regeneration in situ . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Confluent quiescent ECs were incubated with or without 5 . 0 U / ml rHuEPO for 1 , 6 , and 18 hours , and supernatant concentrations of plasminogen activator inhibitor 1 ( PAI 1 ) : antigen ( Ag ) , tissue plasminogen activator and thrombomodulin , and supernatant activities of tissue factor pathway inhibitor and von Willebrand factor were measured . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Direct and reverse fibrin zymography indicated the presence of urokinase like plasminogen activator ( u PA ) and PAI 1 in U 251 conditioned media and cell lysates . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Antigen levels of tissue plasminogen activator ( t PA ) , urokinase type plasminogen activator ( u PA ) , plasminogen activator inhibitors type 1 ( PAI 1 ) and PAI 2 in GCF were determined with ELISAs and 17 beta oestradiol and progesterone in serum with radioimmunoassays . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In HuH 7 cells , the antigen and mRNA levels of plasminogen activator inhibitor type 1 ( PAI 1 ) , an acute phase protein produced by hepatocytes , were increased in response to stimulation with either IL 6 or IL 1 beta or both , but HC 2 antigen and mRNA levels were not changed by the same stimulation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Though the secreted antigens for tissue type plasminogen activator ( t PA ) and type 1 plasminogen activator inhibitor ( PAI 1 ) in the conditioned medium ( CM ) of HUVECs were simultaneously increased at 43 degrees C during this period , the increase in the levels of t PA ( about 26 . 6 fold at 120 min ) was greater than that of PAI 1 ( 1 . 8 fold at 120 min ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Interleukin 1 induction of type 1 plasminogen activator inhibitor ( PAI 1 ) gene expression in the mouse hepatocyte line , AML 12 . ^^^ Type 1 plasminogen activator inhibitor ( PAI 1 ) , the major regulator of fibrinolysis , is an important component of the acute phase ( AP ) response , the coordinated systemic reaction of an organism to tissue injury . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Several newer markers for vascular distress , such as tissue plasminogen activator ( TPA ) , tissue plasminogen activator inhibitor 1 ( PAI 1 ) , TPA / PAI 1 complex , and the newly reported inhibitor of the coagulation process , namely , tissue factor pathway inhibitor ( TFPI ) , have been implicated in the pathogenesis of pulmonary hypertension . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma levels of factor 7 clotting activity ( F VIIc ) , plasminogen activator inhibitor 1 ( PAI 1 ) activity and antigen , tissue type plasminogen activator ( t PA ) activity significantly differed in men with liver steatosis ( n = 31 ) as compared with those without steatosis ( n = 33 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The international standard for plasminogen activator inhibitor 1 ( PAI 1 ) activity . ^^^ Since the finding that plasminogen activator inhibitor 1 ( PAI 1 ) may influence the initiation and progression of acute myocardial infarction , the assay of PAI 1 in plasma using a variety of commercial kits has become commonplace . ^^^ Since PAI 1 inhibits the 2 major plasminogen activators , tissue type plasminogen activator ( t PA ) and urinary type plasminogen activator ( u PA ) in an equimolar manner it was important to establish the potency of the PAI 1 inhibitor in terms of both t PA and u PA neutralisation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Protein and mRNA expression of TGF beta isoforms , TGF beta 1 , beta 2 and beta 3 , and deposition of fibronectin containing extra domain A ( fibronectin EDA+ ) and plasminogen activator inhibitor 1 ( PAI 1 ) were studied in human chronic glomerulonephritis and diabetic nephropathy . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor ( PAI 1 ) and non insulin dependent diabetes in Pima Indians , south Asians and Europeans . ^^^ Activity of plasminogen activator inhibitor 1 ( PAI 1 ) , a potent inhibitor of fibrinolysis , is raised in non insulin dependent diabetes mellitus ( NIDDM ) and may contribute to excess macrovascular disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Increased levels of plasminogen activator inhibitor ( PAI 1 ) have been found in atherosclerotic arteries . ^^^ In this study tissue plasminogen activator ( t PA ) , urokinase type plasminogen activator ( u PA ) and PAI 1 were localized in arterial biopsies of healthy and atherosclerotic vessels by immunohistochemistry . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
These results suggest neutrophil membrane proteolytic activity could assist thrombus dissolution and may be of particular value in assisting early clot dissolution by plasmin and when clot stabilization occurs through plasminogen activator inhibitor 1 ( PAI 1 ) inhibition of plasminogen activation . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To study whether increased resistance in the placental circulation changes the plasma levels of plasminogen activators types 1 and 2 ( PAI 1 and PAI 2 ) in severe preeclampsia , the levels of PAI 1 activity and PAI 2 antigen were determined in 33 severely preeclamptic and 22 normal pregnant women during gestational weeks 24 35 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Levels of thrombin antithrombin ( TAT ) complexes , tissue plasminogen activator ( t PA ) activity and plasminogen activator inhibitor 1 ( PAI 1 ) activity were determined in femoral vein blood from both limbs during and after surgery . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tumour necrosis factor alpha ( TNF alpha ) and interleukin 1 beta ( IL 1 beta ) increased in several , but not all , cell lines the production of urokinase type plasminogen activator ( uPA ) , tissue type PA ( tPA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) as analysed by zymography , enzyme immunoassays and Northern analysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the present study we examined the in vitro regulation of plasminogen activator inhibitor 1 ( PAI 1 ) expression in peritubular cells recovered from 20 day old rat testes . ^^^ Given that PAI 1 inhibits Sertoli cell plasminogen activator activity and that bFGF and TGF alpha are synthesized by Sertoli cells , these factors are likely to interact to regulate protease activity in localized regions of the seminiferous tubule . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This review focuses on the main components of the fibrinolytic system tissue plasminogen activator ( tPA ) , urokinase ( uPA ) and plasminogen activator inhibitor ( PAI 1 ) and on thrombin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Associations between increased plasma concentrations of the three haemostatic factors fibrinogen , Factor 7 and plasminogen activator inhibitor 1 ( PAI 1 ) and cardiovascular disease ( CVD ) have recently been demonstrated in epidemiological studies . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The aim of the present study was to elucidate whether marked job stress affects the parameters of blood coagulation and fibrinolysis , such as plasma fibrinogen concentration , tissue plasminogen activator ( t PA ) , and plasminogen activator inhibitor 1 ( PAI 1 ) activities , in 213 middleaged male workers in a computer producing factory . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The resulting cell line acquired an almost infinite lifespan , was morphologically unchanged , expressed SV 40 antigen , and coexpressed von Willebrand factor ( vWF ) , tissue plasminogen activator ( t PA ) , plasminogen activator inhibitor 1 ( PAI 1 ) , angiotensin conversion enzyme ( ACE ) , and endothelin converting enzyme ( ECE ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Basal plasma tissue plasminogen activator antigen , PAI 1 total antigen and PAI 1 `` active ' ' antigen were unaffected by therapy ( 8 . 4 + / 0 . 5 vs 8 . 6 + / 0 . 5 ng / ml , 118 + / 20 vs 124 + / 16 ng / ml and 21 + / 7 vs 30 + / 7 ng / ml , respectively ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor type 1 ( PAI 1 ) levels rose rapidly after IPC only in the controls and non anticoagulated CVI patients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
One week before and 1 week after the conditioning programs data were collected for body weight , percentage body fat , VO 2 max and 12 h fasting blood levels of total tissue type plasminogen activator ( t PA ) , tissue type plasminogen activator activity ( t PAa ) , total plasminogen activator inhibitor ( PAI 1 ) , plasminogen activator inhibitor activity ( PAI 1a ) , cholesterol ( CHOL ) , triglycerides ( TG ) , and high density lipoprotein cholesterol ( HDL C ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We examined the interference of endogenous inhibitors such as plasminogen activator inhibitor 1 ( PAI 1 ) and alpha 2 antiplasmin , and that of an endogenous activator namely single chain urokinase type plasminogen activator ( scu PA ) on the Coaset t PA assay . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
After both placebo and 6 and 18 weeks of 1 SRO treatment , the following parameters were measured : sitting blood pressure by mercury sphygmomanometer ; platelet aggregation , plasma beta thromboglobulin ( BTG ) , platelet factor 4 ( PF 4 ) , and plasminogen activator inhibitor 1 ( PAI 1 ) by means of ELISA methods ; and euglobulin lysis time before ( ELT ) and after standardized ( 10 min ) venous occlusion ( ELT VO ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is related to insulin resistance and several components of the insulin resistance syndrome , and PAI 1 levels are elevated in subjects with non insulin dependent diabetes mellitus . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The following measurements were undertaken : Acute Physiology and Chronic Health Evaluation ( APACHE ) 2 score , multiple organ failure ( MOF ) score , plasma levels of thrombin antithrombin 3 complexes ( TAT ) , antithrombin 3 ( AT 3 ) , protein C antigen , factor 12 , and plasminogen activator inhibitor type 1 antigen ( PAI 1 ) , neopterin , and interleukin 6 ( IL 6 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The role of urokinase type plasminogen activator and its inhibitor PAI 1 in gastric cancer . ^^^ BACKGROUND : It has been proposed that the serine protease urokinase type plasminogen activator ( UPA ) and its inhibitor type 1 ( PAI 1 ) may play an important part in cancer spread and metastasis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In this study we investigated the correlation of the Plasminogen Activator Inhibitor 1 ( PAI 1 ) , which is the specific inhibitor of uPA and which seems to be important for tumour formation , with prognosis in breast cancer . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Prognostic significance of plasminogen activator inhibitor 1 ( PAI 1 ) in primary breast carcinoma ] . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Evidence has been presented that primary breast cancer patients with tumors containing high levels of u PA experience a worse prognosis . u PA and its inhibitor , type 1 plasminogen activator inhibitor ( PAI 1 ) , are potentially important prognostic factors in breast cancer to identify patients at high risk for recurrence and also in the classification of clinically important subgroups . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Addition of exogenous plasminogen activator inhibitor 1 ( PAI 1 ) to fibrin clots inhibits fibrinolysis in vivo . ^^^ These results indicate that active PAI 1 accumulates in porcine coronary artery thrombi in concentrations markedly higher than those present in plasma and that PAI 1 may be an important determinant of the known resistance of platelet rich thrombi to lysis by tissue type plasminogen activator . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Although the relation of insulin to CHD in the general population is somewhat controversial , insulin is clearly related to multiple cardiovascular risk factors ( especially elevated triglyceride , decreased high density lipoprotein , small dense low density lipoprotein , impaired glucose tolerance and increased plasminogen activator inhibitor 1 ( PAI 1 ) ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
It has been shown recently in epidemiological studies , that increased concentration of several factors , mainly fibrinogen , factor 7 , von Willebrand factor ( vWF ) , and the fibrinolytic variables plasminogen activator inhibitor 1 ( PAI 1 ) and tissue plasminogen activator ( t PA ) , can be considered as risk factors for CHD . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The present study was undertaken to determine whether uPA and plasminogen activator inhibitor 1 ( PAI 1 ) mRNAs are expressed in vivo in the decidua of pregnant rats and in the deciduoma of `` pseudopregnant ' ' rats . ^^^ Plasminogen activator inhibitor 1 mRNA was scattered in the decidualized endometrium , but greater amounts of PAI 1 mRNA were found in the fetal tissue on Day 10 of pregnancy . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We previously reported significantly elevated levels of plasminogen activator inhibitor type 1 ( PAI 1 ) in plasma and placenta from pregnant women with severe pre eclampsia , and pre eclampsia is a frequent problem in molar pregnancies . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NO metabolites ( NO 2 and NO 3 ) , endothelin ( ET 1 ) , tissue plasminogen activator ( tPA ) , plasminogen activator inhibitor ( PAI 1 ) , fibrinogen , D dimer , fibrinopeptide A , beta thromboglobulin ( beta TG ) , blood viscosity , plasma viscosity , haematocrit ( Htc ) and red blood cell ( RBC ) filterability index ( FI ) were determined during headache free periods . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) plays a key role in limiting plasminogen activation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is involved in the accumulation of extracellular matrix in various tissues . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fibrin zymographic studies indicated that jararhagin increased tissue type plasminogen activator ( tPA ) activity by the dissociation of a complex of tPA with type 1 plasminogen activator inhibitor ( PAI 1 ) . alpha 2 Plasmin inhibitor ( alpha 2 PI ) activity in the plasma was measured using a synthetic chromogenic substrate method after incubation with jararhagin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Activation of fibrinolysis by t PA through generation of plasmin is complemented with multifactorial desactivation of platelets by PGI 2 and a selective inhibition of release of plasminogen activator inhibitor 1 ( PAI 1 ) from platelets by NO . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The series consists of 12 subjects ( 6 males , 6 females , mean age 52 + / 7 ) , suffering from acute myocardial infarction ; just after the first symptoms and instrumental signs ( before the thrombolysis ) and after two weeks a venous blood withdrawal was done ; on the plasma of each sample the determination of fibrinogen ( F ) ( coagulative method ) , tissue plasminogen activator ( t PA ) , plasminogen activator inhibitor ( PAI 1 ) , D dimer ( D D ) , fibrinopeptide A ( FPA ) and betathromboglobulin ( BTG ) ( ELISA methods ) was performed . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Defects in the fibrinolytic system decreased tissue type plasminogen activator ( t PA ) activity and elevated levels of plasminogen activator inhibitor ( PAI 1 ) , in patients with SLE have been associated with an increased tendency to thrombosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the present study we investigated plasma levels of plasminogen activator inhibitor 1 ( PAI 1 ) , fibrinogen and von Willebrand factor ( vWF ) in borderline hypertensive ( BHT ) men [ diastolic blood pressure ( DBP ) 85 94 mmHg , n = 75 ] and age matched normotensive ( NT ) control subjects ( DBP < or = 80 mmHg , n = 75 ) , in relation to smoking , body mass index ( BMI ) and fasting lipoprotein and insulin levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The increase seen for MCP 1 mRNA at 8 h was also observed for IL 8 mRNA but was not apparent for growth related gene expressions , urokinase type plasminogen activator ( u PA ) , and plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Present studies are concerned with the interactions of the tumour associated proteases , guanidinobenzoatase ( GB ) and plasminogen activators ( PAs ) with PAs inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
At the end of each treatment , blood samples for assessment of platelet aggregation and platelet release of platelet factor 4 ( PF 4 ) and for assessment of fibrinolysis , estimated by tissue plasminogen activator ( t PA ) , plasminogen activator inhibitor type 1 ( PAI 1 ) , and euglobulin clot lysis time ( ECLT ) , were taken , first at rest , then immediately after five to ten minutes of vigorous exercise , and finally after the subsequent hour of recovery rest . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The antigen levels of plasminogen activator inhibitor type 1 ( PAI 1 ) , plasminogen activator inhibitor type 2 ( PAI 2 ) , tissue type plasminogen activator ( t PA ) , and urokinase type plasminogen activator ( u PA ) were measured during pregnancy and severe preeclampsia . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Cell bound uPA is regulated by plasminogen activator inhibitor type 1 ( PAI 1 ) or type 2 ( PAI 2 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
With reference to plasminogen activator inhibitor 1 ( PAI 1 ) , more PAI 1 was released from cells grown on PVC than from those on the control plates coated with gelatin and collagen A . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In plasma samples of 38 patients ( median age : 49 years ) receiving CMF ( schedule 1 21 or 1 8 ) for Stage 2 breast cancer , we evaluated : PT , aPTT , antithrombin 3 ( AT 3 ) , protein C ( PC ) , protein S ( PS ) , thrombin antithrombin complex ( TAT ) , prothrombin fragment F 1 + 2 ( F 1 + 2 ) , fibrinogen ( Fbg ) , tissue type plasminogen activator ( t PA ) , plasminogen activator inhibitor ( PAI 1 ) and D dimer ( D D ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The first part of the paper deals with the relationship between two inhibiting factors of the complex enzyme cascade regulating fibrinolysis , namely plasminogen activator inhibitor type 1 ( PAI 1 ) and lipoprotein ( a ) ( Lp ( a ) ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Lipoprotein ( a ) , plasminogen activator inhibitor ( PAI 1 ) , tissue plasminogen activator ( t PA ) and the PAI 1 / t PA ratio were significantly lower in controls than in coronary , epiaortic and peripheral artery disease patients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Endothelial cells play a central role in fibrinolysis due to their production of both tissue plasminogen activator ( t PA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Our main questions were whether and how the concentration of tissue plasminogen activator ( tPA ) and plasminogen activator inhibitors of type 1 ( PAI 1 ) and type 2 ( PAI 2 ) change in the plasma throughout normal labor . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : Fourteen patients undergoing laparoscopic cholecystectomy and 12 patients undergoing open cholecystectomy had blood taken in the perioperative period for fibrinopeptide A ( FPA ) prothrombin fragment F1 . 2 , antithrombin 3 , tissue plasminogen activator ( tPA ) and its fast acting inhibitor plasminogen activator inhibitor 1 ( PAI 1 antigen and activity ) , and the euglobulin clot lysis time ( ECLT ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasmin antiplasmin complexes ( PAP ) , fibrinogen and fibrin degradation products ( FgDP , FnDP ) were significantly increased , and the activity of plasminogen activator inhibitor ( PAI 1 ) was slightly reduced , denoting an activation of fibrinolysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To assess whether plasminogen activator inhibitor 1 ( PAI 1 ) activity is elevated in the progeny of young coronary men , 193 young subjects were recruited and divided into two groups . ^^^ We measured PAI 1 activity , tissue type plasminogen activator ( t PA ) antigen , a 2 antiplasmin , fibrinogen , lipids and apolipoproteins in both groups . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have previously shown that GH deficient adults have increased concentrations of fibrinogen and plasminogen activator inhibitor ( PAI 1 ) activity . ^^^ PAI 1 activity , PAI 1 antigen and tissue plasminogen activator ( t PA ) antigen levels decreased during the GH treatment period ( p < 0 . 05 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
RESULTS : Urokinase type plasminogen activator ( uPA ) , uPA receptor , tissue type plasminogen activator ( tPA ) , plasminogen activator inhibitor 1 ( PAI 1 ) , matrix metalloproteinases MMP 8 , MMP 9 and tissue inhibitor of metalloproteinases TIMP 1 were measured by ELISA . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Hormone replacement therapy in postmenopausal women has been shown to enhance fibrinolytic capacity by lowering plasminogen activator inhibitor 1 ( PAI 1 ) and tissue plasminogen activator inhibitor ( tPA ) antigen values . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This study attempted to verify the existence of a relationship between oxidative stress documented by malondialdehyde ( MDA ) and superoxide dismutase ( SOD ) and fibrinolysis analysed by tissue plasminogen activator ( tPA ) and its inhibitor ( PAI 1 ) in diabetes mellitus . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Alterations in the plasma levels of tissue plasminogen activator ( t PA ) and plasminogen activator inhibitor ( PAI 1 ) as observed in various liver disorders are attributed to deranged liver function . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : Concentrations of the plasminogen activators pro urokinase , tissue plasminogen activator , plasminogen activator inhibitors 1 and 2 ( PAI 1 and PAI 2 ) , plasminogen , and fibrin split product D dimer in synovial fluid ( SF ) and blood plasma of 29 patients with rheumatoid arthritis ( RA ) were compared with the concentrations of 18 patients with spondyloarthropathy ( SpA ) . ^^^ Joint destruction correlated significantly with increasing PAI 1 antigen and with decreasing plasminogen in SF when results from all patients were pooled . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
One candidate gene in this region is Plasminogen Activator Inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : Although elevated plasminogen activator inhibitor 1 ( PAI 1 ) is associated with obesity and may be a risk factor for cardiovascular disease , the mechanism ( s ) that lead to this elevation , and the tissue / cellular origins of this increase , remain to be defined . ^^^ MATERIALS AND METHODS : PAI 1 activity and antigen levels were determined using a tissue type plasminogen activator ( t PA ) binding assay and Western blotting . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have studied conformational changes of type 1 plasminogen activator inhibitor ( PAI 1 ) during a temperature dependent inhibitor substrate transition by measuring susceptibility of the molecule to non target proteinases . ^^^ Accordingly , PAI 1 was recovered in a reactive centre cleaved form from incubations with urokinase type plasminogen activator ( uPA ) and tissue type plasminogen activator ( tPA ) at 0 degree C , but not at 37 degrees C . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Patients receiving CyA had significantly higher concentrations of plasma fibrinogen ( P < 0 . 05 ) , prothrombin fragment 1 + 2 ( F 1 + 2 ; P < 0 . 05 ) , plasminogen activator inhibitor 1 ( PAI 1 ; P < 0 . 05 ) , and von Willebrand factor antigen ( P < 0 . 05 ) than did patients not taking CyA . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
An increased incidence of events was associated with higher baseline concentrations of tissue plasminogen activator ( TPA ) antigen ( P = . 0002 ) , plasminogen activator inhibitor 1 ( PAI 1 ) activity ( P = . 02 ) , and PAI 1 antigen ( P = . 001 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Since TNF alpha may contribute to thrombotic complications in sepsis patients , we determined markers of thrombin activation , parameters of the fibrinolytic system ( D dimer , tissue plasminogen activator antigen ( tPA ) urinary type plasminogen activator antigen ( uPA ) , plasminogen activator inhibitor antigen ( PAI 1 ) and von Willebrand factor antigen ( vWF ) in 30 patients with sepsis or septic shock . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A strong inverse correlation was seen between plasma plasminogen activator inhibitor 1 ( PAI 1 ) activity and Ks ( r = 0 . 603 , p < 0 . 001 ) or fiber mass length ratio ( r = 0 . 565 , p < 0 . 001 ) in the patient group . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The activities , antigens and messenger RNA ( mRNA ) levels of urokinase type plasminogen activator ( uPA ) and plasminogen activator inhibitor 1 ( PAI 1 ) in articular cartilage were measured in patients with no history of joint diseases ( control ) , those with osteoarthritis ( OA ) classified into osteophyte formed site ( OS ) and weight bearing site ( WS ) , and in patients with rheumatoid arthritis ( RA ) . 2 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have previously reported that plasminogen activator inhibitor type 1 ( PAI 1 ) expression in endothelial cells ( ECs ) can be modulated differently by smooth muscle cells depending on their origin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
PURPOSE : The plasminogen system , which includes tissue type plasminogen activator ( tPA ) , urokinase type plasminogen activator ( uPA ) , and their main inhibitor , plasminogen activator inhibitor type 1 ( PAI 1 ) , plays a major role in both fibrinolysis and tissue remodeling . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The concentrations of matrix metalloproteinase 1 ( MMP 1 ) , matrix metalloproteinase 8 ( MMP 8 ) , matrix metalloproteinase 9 ( MMP 9 ) , lactoferrin and urokinase plasminogen activator ( uPA ) , tissue type plasminogen activator ( tPA ) and the inhibitors , tissue inhibitor of metalloproteinase 1 ( TIMP 1 ) , plasminogen activator inhibitor 1 ( PAI 1 ) , plasminogen activator inhibitor ( PAI 2 ) , and alpha 2 macroglobulin in the synovial fluids of patients with rheumatoid arthritis was determined before and during chemical synoviorthesis with a sodium salt of the fatty acids from cod liver oil ( Varicocid ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor type 1 ( PAI 1 ) ( assayed by ELISA , n = 9 ) , the PAI 1 binding protein , vitronectin ( immunoprecipitation , n = 3 ) and tissue factor ( ELISA , n = 3 ) were not affected by LIF , but fibrinogen production increased up to twofold with LIF ( 500 U / ml ; Western blot , n= 3 ) . ^^^ In HUVECs , synthesis of tissue type plasminogen activator or PAI 1 was not altered by LIF or OSM ( ELISA , n = 9 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The rise in blood fibrinolysis is mainly due to an increase in tissue type plasminogen activator ( t PA ) and a decrease in its main inhibitor plasminogen activator inhibitor ( PAI 1 ) which are released from the endothelial cells of the vessel wall . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To clarify the specific expression and regulation of mRNAs for urokinase ( uPA ) , its receptor ( uPAR ) , and type 1 plasminogen activator inhibitor ( PAI 1 ) , 1 analyzed RNA from four human cancer cell lines by RNA blotting after treatment with cycloheximide , anisomycin , emetine or puromycin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The genetic polymorphism of fibrinogen , plasminogen , PAI 1 and some other compounds modifying circulating fibrinogen levels are also discussed in this review . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The incubation of mesangial cells with TSP increased the secretion of tissue type plasminogen activator ( tPA ) and urokinase type plasminogen activator ( uPA ) , while plasminogen activator inhibitor type 1 ( PAI 1 ) decreased . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Here we compare these natural mutations with reciprocal mutations in recombinants that restore the inhibitory stability of a labile member of the family , plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Pearson and Spearman correlation coefficients were calculated to determine associations between the variables of interest and tissue plasminogen activator ( t PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) activities in the basal state and after stimulation with maximal exercise . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Urokinase plasminogen activator ( uPA ) and plasminogen activator inhibitor 1 ( PAI 1 ) were administered to determine the effect of TGF beta activation on the axial length in normal and FDM eyes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have developed a first generation kinetic model that can be used to simulate the effects of secretion , inhibition , and clearance reactions on the concentrations of active tPA , active plasminogen activator inhibitor type 1 ( PAI 1 ) , and tPA / PAI 1 complex in the circulation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A single protein of Mr 45 , 000 co purified with hepatoma cell derived Vn , which was immunologically identified as type 1 plasminogen activator inhibitor ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The mechanism of regulation of the plasminogen activator inhibitor type 1 ( PAI 1 ) gene by transforming growth factor beta 1 ( TGF beta 1 ) was studied in vitro and in vivo in endothelial cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Type 1 plasminogen activator inhibitor ( PAI 1 ) is a key regulator of the fibrinolytic cascade that is stored in a rapidly releasable form within platelet alpha granules . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : We measured the coagulation activation marker prothrombin fragment F 1 + 2 ( F 1 + 2 ) , fibrinogen , plasminogen activator inhibitor 1 activity ( PAI 1 ) , interleukin 6 ( IL 6 ) , insulin , lipids and lipoprotein ( a ) ( Lp ( a ) ) , in 12 patients with chronic renal disease before and after gemfibrozil . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
However , the incubation of mesangial cells with renin for 24 hours induced a significant increase ( 170 % of control , P = 0 . 04 ) of plasminogen activator inhibitor 1 ( PAI 1 ) antigen in the conditioned medium . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Murine recombinant two chain u PA bound to murine endothelioma cells was quantitatively inhibited by murine plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^ Thus , the interactions between murine plasminogen , u PA and PAI 1 are qualitatively similar to those between their human counterparts . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
When plasminogen activator inhibitor 1 ( PAI 1 ; 100 muM in an osmotic minipump ) was infused into the kitten visual cortex , OD plasticity was suppressed ; i . e . a significantly large number of binocular cells was recorded in the PAI 1 infused cortex following monocular deprivation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Human peritoneal mesothelial cells ( HMC ) play a critical role in maintaining the intraperitoneal balance between fibrinolysis and coagulation by expressing the fibrinolytic enzyme tissue type plasminogen activator ( t PA ) as well as a specific plasminogen activator inhibitor , PAI 1 , and the procoagulant protein tissue factor ( TF ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Parallel experiments with the cultured endothelial cells and BFA indicated that the fungal metabolite enhanced a rate of accumulation of plasminogen activator inhibitor 1 ( PAI 1 ) antigen , but not of tissue type plasminogen activator antigen in the medium . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The same concentrations of Dex led to a decrease in urokinase type plasminogen activator ( u PA ) synthesis and an increase in plasminogen activator inhibitor type 1 ( PAI 1 ) synthesis by SCC cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In addition to routine coagulation tests , antithrombin 3 , von Willebrand factor ( vWF ) , prothrombin fragment 1+2 ( F1+2 ) , thrombin antithrombin complex ( TAT ) , D dimer ( DD ) , and plasminogen activator inhibitor type 1 ( PAI 1 ) were measured in the plasma at the time of diagnosis and as soon as remission was achieved after therapy with plasma exchange and Iloprost . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor ( PAI 1 ) , tissue type plasminogen activator ( tPA ) and von Willebrand factor ( vWF ) concentrations were measured by ELISA in the supernatant of the following cultures : endothelial cells from human umbilical vein ( HUVEC ) ; human colon cancer cells ( HRT 18 ) ; and co culture cells of HUVEC + HRT 18 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The expression of tissue type plasminogen activator ( t PA ) and a number of metalloproteases as well as plasminogen activator inhibitor 1 ( PAI 1 ) and tissue inhibitor of metalloproteases 1 ( TIMP 1 ) was analyzed in the central nervous system ( CNS ) of normal control and multiple sclerosis ( MS ) cases by immunohistopathology . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In this study , the localization of plasminogen activator inhibitor 1 ( PAI 1 ) and its association with glomerular subepithelial deposits of vitronectin ( VN ) in membranous nephropathy ( MN ) was evaluated . ^^^ Renal biopsy tissue from 30 patients with MN along with specimens of normal kidney removed from six patients with renal tumors were examined for glomerular deposits of urokinase type plasminogen activator , tissue type plasminogen activator ( t PA ) , PAI 1 , VN , and fibrinogen by using immunofluorescence and immunoelectron microscopic techniques . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma fibrinolytic potential is reduced in NIDDM and it is known that glucose and insulin can modulate plasminogen activator inhibitor ( PAI 1 ) and tissue plasminogen activator ( t PA ) secretion and can therefore regulate local fibrinolysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma tissue type plasminogen activator ( t PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) antigen levels were significantly higher in type 4 HL than in the controls . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Thrombomodulin , plasminogen activator inhibitor type 1 ( PAI 1 ) and fibronectin as biomarkers of endothelial damage in preeclampsia and eclampsia . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue plasminogen activator ( T PA ) and tissue plasminogen activator inhibitor ( PAI 1 ) in patients after head injury ] . ^^^ The following factors of fibrinolysis : tissue plasminogen activator ( t PA ) and tissue plasminogen activator inhibitor 1 ( PAI 1 ) play an important role in patients after trauma . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The system of plasminogen activation is controlled at several levels : plasminogen activator inhibitors ( PAI 1 and PAI 2 ) counteract the activity of plasminogen activators and alpha 2 antiplasmin inhibits the activity of plasmin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In 90 middle aged male volunteers , psychosocial stress related variables , defined as feelings of excessive tiredness and as personality and behavioral factors reflecting a stress inducing life style ( type A behavior , hostility , and anger ) , were significantly correlated with the hyperinsulinemia , hyperglycemia , dyslipidemia , hypertension , increased abdominal obesity , and increased plasminogen activator inhibitor 1 ( PAI 1 ) antigen comprising the IRS . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Coagulation was explored by standard clotting tests and by measurement of prothrombin complex factors , factor 8 ( 8 : C ) and antithrombin 3 ( ATIII ) , protein C ( PC ) and protein S ( PS ) activities , while fibrinolytic potential was evaluated using D dimer , tissue plasminogen activator ( t PA ) and plasminogen activator inhibitor ( PAI 1 ) assays . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The plasminogen activator system ( PA system ) consists of urokinase type plasminogen activator ( uPA ) , tissue type PA ( tPA ) , as well as the two types of plasminogen activator inhibitors ( PAI 1 and PAI 2 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Ambulatory blood pressure profiles and plasminogen activator inhibitor ( PAI 1 ) activity in lean women with and without the polycystic ovary syndrome . ^^^ OBJECTIVE : Hyperinsulinaemic women with the polycystic ovary syndrome ( PCOS ) may be at increased risk of vascular disease later in life , mediated by blood pressure or lipid abnormalities or by elevated plasma levels of plasminogen activator inhibitor 1 ( PAI 1 ) activity . ^^^ PAI 1 and plasminogen are involved in ovarian follicle maturation and the present finding suggests a biologically plausible link between hyperinsulinaemia , anovulation and vascular risk in PCOS . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We estimated the euglobulin fibrinolytic activity ( EFA ) and , the activities and antigens of both tissue type plasminogen activator ( t PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Expression of urokinase type plasminogen activator ( uPA ) and its inhibitor PAI 1 in benign , borderline , malignant primary and metastatic ovarian tumors . ^^^ Elevated levels of expression of the urokinase type plasminogen activator ( uPA ) and its inhibitor PAI 1 have shown to be related to poor prognosis in a variety of cancer types . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor type 1 ( PAI 1 ) , a member of serine proteinase inhibitor superfamily , is known to inhibit thrombin in the presence of either heparin or vitronectin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We show here that lungs of mice exposed to hyperoxia overproduce plasminogen activator inhibitor 1 ( PAI 1 ) , and that PAI 1 upregulation impairs fibrinolytic activity in the alveolar compartment . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The serpin plasminogen activator inhibitor 1 ( PAI 1 ) folds into an active structure and then converts slowly to a more stable , but low activity , `` latent ' ' conformation [ Hekman , C . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In this study , the expression of three glycoproteins that play a role in the plasminogen activator system as activators of proteolysis urokinase type plasminogen activator ( u PA ) , tissue type plasminogen activator ( t PA ) , and plasminogen activator inhibitor type 1 ( PAI 1 ) were studied in various components of dedifferentiated chondrosarcomas of bone . ^^^ CONCLUSIONS : The current study documents the overexpression of u PA , t PA , and PAI 1 in dedifferentiated chondrosarcoma and suggests involvement of the plasminogen activator system in the biology of these tumors . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The glomerular biosynthesis of fibronectin and plasminogen activator inhibitor 1 ( PAI 1 ) , and cortical mRNA expression for fibronectin , collagen 1 , and PAI 1 ( which may be affected by TGF beta ) in the HS rats were elevated , compared with the LS rats . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The effects of the endocrine milieu on growth , invasion and metastasis , associated with neovascularization of endometrial cancer , the expression of plasminogen activator inhibitor 1 ( PAI 1 ) , and its mRNA in endometrial atypical hyperplasia and cancer , and normal endometria as controls were determined in premenopausal and postmenopausal women . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : Plasminogen activator inhibitor type 1 ( PAI 1 ) implicated as a determinant of thrombosis , and possibly of atherosclerosis , is increased approximately four fold in the blood of subjects with type 2 diabetes , and the increase is closely correlated with concentrations of insulin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We examined the potential of in vivo linkage of plasminogen activator inhibitor 1 ( PAI 1 ) and angiotensin 2 ( Ang 2 ) in the setting of endothelial injury and sclerosis following radiation injury in the rat . ^^^ PAI 1 is a major physiological inhibitor of the plasminogen activator ( PA ) / plasmin system , a key regulator of fibrinolysis and extracellular matrix ( ECM ) turnover . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A three dimensional reconstruction analysis of localization of phosphodiester and phosphorothioate oligonucleotide antisense to type 1 plasminogen activator inhibitor ( PAI 1 ) mRNA within endothelial cells is described . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The activity of plasminogen activator inhibitor 1 ( PAI 1 ) , an inhibitor of fibrinolysis , is associated with insulin resistance ( IR ) and the risk of venous and arterial thrombotic cardiovascular disease ( CVD ) in the general population , and may behave as an acute phase reactant . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : Cysteine proteases [ cathepsin B ( CATB ) , cathepsin L ( CATL ) ] , the serine protease urokinase type plasminogen activator ( UPA ) and its inhibitor type 1 ( PAI 1 ) play an important part in cancer invasion . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue type plasminogen activator ( t PA ) and its physiological inhibitor , plasminogen activator inhibitor 1 ( PAI 1 ) , are known to be synthesized by vascular endothelial cells and to play important roles in regulating the fibrinolytic activity of plasma . ^^^ We found that a new butadiene derivative , ( 3E , 4E ) 3 benzylidene 4 ( 3 , 4 , 5 trimethoxybenzylidene ) pyrrolidine 2 , 5 dione ( T 686 ) , inhibits PAI 1 production without affecting plasminogen activator ( PA ) synthesis in cultured bovine endothelial cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In addition to lowering serum triglyceride levels , fibrates have also been shown to reduce elevated plasma plasminogen activator inhibitor 1 ( PAI 1 ) levels in vivo . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To investigate the relationship between an insertion / deletion ( 4G / 5G ) polymorphism in the promoter region of the plasminogen activator inhibitor 1 ( PAI 1 ) gene and the phenotypes of PAI 1 levels , coronary atheroma , and a past history of coronary thrombosis , we studied 453 patients ( 320 men and 133 women ) characterized by coronary angiography . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Expression of plasminogen activator inhibitor type 1 ( PAI 1 ) , a member of the SERPIN gene family that functions to regulate the plasmin based pericellular proteolytic cascade , is growth state regulated in normal rat kidney ( NRK ) cells ( Ryan and Higgins , 1990 , J . ^^^ The IgG fractions of two different antisera which neutralize the ability of PAI 1 to complex with and thereby inhibit the catalytic activity of urokinase plasminogen activator significantly reduced ( by 25 35 % ) the incidence of cells displaying the serum stimulated phenotype ; antibodies that bind PAI 1 but do not block PAI 1 inhibitory activity were without effect . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In this study , we examined the effect of 15 HPETE on the release of tissue type plasminogen activator ( t PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) from cultured human umbilical vein endothelial cells ( HUVEC ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Post mortem concentration of tissue plasminogen activator ( t PA ) and plasminogen activator inhibitor ( PAI 1 ) in the vitreous body of the human eye ] . ^^^ Earlier we observed after sudden death high concentrations of t PA Ag in plasma with strong activation of fibrinolysis , consumption of PAI 1 , plasminogen , fibrinogen , alfa 2 antiplasmin and a big increase of FDP . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : Insulin and its precursors found in increased plasma concentrations in non insulin dependent diabetes mellitus ( NIDDM ) augment synthesis of plasminogen activator inhibitor type 1 ( PAI 1 ) in Hep G 2 cells in vitro and in rabbit liver in vivo . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Baseline cross sectional changes and 1 year changes in insulin resistance , fasting serum levels of insulin , C peptide , proinsulin , glucose , and lipids as well as weight , mean blood pressure , and plasminogen activator inhibitor 1 ( PAI 1 ) values were recorded . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) , the primary inhibitor of tissue type plasminogen activator and urokinase , is known to convert readily to a latent form by insertion of the reactive center loop into a central beta sheet . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We cross sectionally measured plasminogen activator inhibitor 1 ( PAI 1 ) activity , fibrinogen , factor 7 ( FVII : C ) and 8 ( FVIII : C ) coagulant activity , and von Willebrand factor antigen ( VWF : Ag ) in 162 traditional horticulturalists older than 40 years from the tropical island of Kitava , Papua New Guinea , where the intake of western food is negligible and where stroke and ischaemic heart disease appear to be absent . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Also the factor 7 coagulant activity ( F 7 : C ) , tissue type plasminogen activity ( tPA ) and plasminogen activator inhibitor activity ( PAI 1 ) were not affected by the experimental diets . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We previously demonstrated that lipopolysaccharide ( LPS ) induces plasminogen activator inhibitor 1 ( PAI 1 ) gene expression primarily in endothelial cells in most organs of the mouse , with maximal induction by 3 hours . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : Tetranectin ( TN ) , tissue type plasminogen activator ( t PA ) , and plasminogen activator inhibitor ( PAI 1 ) were quantitatively assessed ( ELISA ) in plasma of 41 patients with RA and 30 healthy subjects , alpha 2 Antiplasmin activity was assessed by the amidolytic method . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : The biological activity of plasminogen ( Plg ) , plasminogen activators ( PA ) , alpha 2 antiplasmin ( alpha 2 AP ) and plasminogen activator inhibitor 1 ( PAI 1 ) was determined by photometric analysis in 15 compensated and 35 decompensated patients with endemic Egyptian hepatosplenomegaly . ^^^ RESULTS : The progressive deterioration of liver function in schistosomal patients , which matched the severity of the disease , led to simultaneous defects in profibrinolytic ( decreased Plg and increased PA and t PA ) and antifibrinolytic ( decreased alpha 2 AP and PAI 1 ) factors the latter defects being the most prominent resulting in significant generation of plasmin ( increased APP complexes ) and therefore enhanced fibrinolysis ( increased FbDP and D dimer ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Effects of nicotine treatment ( 4 . 5 mg / kg of nicotine free base / day administered s . c . by osmotic minipumps for 14 days ) on focal ischemic stroke and expression of tissue plasminogen activator ( t PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) in cerebral microvessels were studied in rats in vivo using a reversible ( 1 h ) middle cerebral artery occlusion model . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The serine protease urokinase type plasminogen activator ( uPA ) and its inhibitor , plasminogen activator inhibitor 1 ( PAI 1 ) , appear to have a major function in these processes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
RESULTS : The patients had signs of disturbed fibrinolysis , with elevated plasma levels of tissue plasminogen activator ( tPA ) antigen and plasminogen activator inhibitor ( PAI 1 ) activity at rest , and attenuated responses of tPA antigen and activity to exercise . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Here , we report negative feedback regulation of t PA expression , exerted by t PA or complexes of t PA with its physiological inhibitor , plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We examined the regulation by tumor necrosis factor alpha ( TNF alpha ) of plasminogen activator inhibitor 1 ( PAI 1 ) in cultured peritubular cells recovered from 20 day old rat testes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) , a unique member of the serpin superfamily , plays an important role in fibrinolysis and is an established risk factor for cardiovascular diseases . ^^^ Detailed analysis of the reaction products formed during the interaction between PAI 1 and its target proteinases tissue type plasminogen activator ( t PA ) or urokinase type plasminogen activator ( u PA ) , in the presence of these monoclonal antibodies , revealed two distinct mechanisms of PAI 1 inactivation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Both basal plasminogen activator inhibitor 1 antigen ( PAI 1 Ag ) and activity ( PAI 1 Act ; P < 0 . 05 ) , as well as basal and exercise induced tissue type plasminogen activator antigen ( t PA Ag ; P < 0 . 05 ) , were decreased after training . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is the major physiological inhibitor of plasminogen activators ( PA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) and amino propeptide of type 3 procollagen ( PIIINP ) have been described as markers of hepatic veno occlusive disease ( VOD ) after bone marrow transplantation ( BMT ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Venous blood was collected on fasting from patients and controls to examine the following parameters : fibrinogen ( F ) , factor 7 ( F 7 ) , antithrombin 3 ( AT 3 ) , protein C ( PC ) , protein S ( PS ) using coagulometric methods ( IL ) , and tissue plasminogen activator ( tPA ) , plasminogen activator inhibitor ( PAI 1 ) , fibrinopeptide A ( FPA ) , betathromboglobulin ( BTG ) and dimer D ( D D ) using ELISA methods ( Boehringer ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue plasminogen activator antigen ( t PA : Ag ) and plasminogen activator inhibitor 1 antigen ( PAI 1 : Ag ) released were determined by enzyme immunoassay . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Levels of prothrombin fragments 1 + 2 , D dimers , plasminogen , alpha 2 antiplasmin , tissue plasminogen activator ( tPA ) , and plasminogen activator inhibitor ( PAI 1 ) in venous blood were investigated just before the operation , at the end of the operation and three hours later . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We previously have described plasminogen activator inhibitor 1 ( PAI 1 ) as a possible marker of VOD . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fibrinogen is an established risk factor for stroke and myocardial infarction and high levels of plasminogen activator inhibitor 1 ( PAI 1 ) activity were predictive of a recurrent myocardial infarction . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
IMR 90 cells also produce plasminogen activator inhibitor type 1 ( PAI 1 ) , but Ca SP showed little effect on the PAI 1 production . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) , the major physiologic inhibitor of tissue type plasminogen activator and urokinase , is abundantly expressed in atherosclerotic vascular wall . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Immunoreactivity for the plasminogen activator inhibitor type 1 ( PAI 1 ) was present in normal mesothelium , and substantially increased in inflammation , where , in addition , immunoreactivity was found throughout the submesothelial tissue . ^^^ This PAI 1 was partly co localized with macrophages , as was the urokinase plasminogen activator ( u PA ) , suggesting an involvement of these cells in peritoneal tissue fibrinolysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor type 1 ( PAI 1 ) , the primary physiologic inhibitor of plasminogen activation , is associated with the adhesive glycoprotein vitronectin ( Vn ) in plasma and the extracellular matrix . ^^^ In contrast , inactive forms of PAI 1 ( latent , elastase cleaved , synthetic reactive center loop peptide annealed , or complexed to plasminogen activators ) display greatly reduced affinities for both forms of adsorbed Vn , with relative affinities reduced by more than 2 orders of magnitude . ^^^ This is supported by the observation that PAI 1 associated with beta anhydrotrypsin , which does not undergo rearrangement of beta sheet A , shows no such decrease in affinity , whereas PAI 1 complexed to beta trypsin , which does undergo sheet A rearrangement , displays reduced affinity for Vn similar to PAI 1 . plasminogen activator complexes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Vitronectin ( VN ) is an obligatory cofactor for the inhibition of thrombin by plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^ In contrast , VN does not accelerate the association between tissue type plasminogen activator ( t PA ) and PAI 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Differences were also observed for tissue plasminogen activator ( t PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) with MVEC supernatants or cell lysates . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The estrogen regulated pS 2 protein and the Plasminogen Activator Inhibitor type 1 ( PAI 1 ) have been reported as important tumor parameters both in breast and in ovarian cancer . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasmin production is determined by the balance between plasminogen activators ( PA ) and their inhibitors ( PAI 1 , 2 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
They also had higher levels of fibrinogen , plasminogen activator inhibitor 1 ( PAI 1 ) activity and fasting and steady state C peptide levels during the clamp . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fibrinolytic activity was determined by tissue type plasminogen activator ( tPA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) activities in cultured medium . 3 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue type plasminogen activator ( tPA ) is the chief plasminogen activator in the blood , but its activity is restricted by plasminogen activating inhibitors type 1 ( PAI 1 ) and type 2 ( PAI 2 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The plasminogen activator inhibitor ( PAI 1 ) remained unchanged after anoxia , although wide interindividual variations were seen . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Cultured endothelial cells ( ECs ) produced a constitutive plasminogen activator inhibitor 1 ( PAI 1 ) , whereas primary culture of monocytes from blood did not produce a detectable amount of PAI 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The RNA species encoded by IGFBP 3 ( insulin like growth factor binding protein 3 ) , PAI 1 ( plasminogen activator inhibitor 1 ) and SPARC ( secreted protein acidic and rich in cysteine ; a . k . a . osteonectin ) are overexpressed in senescent human diploid fibroblasts ( HDF ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The present study examined whether TGF beta 1 affects PA and plasminogen activator inhibitor 1 ( PAI 1 ) production by cultured human cytotrophoblasts . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In contrast , plasminogen activator inhibitor 1 ( PAI 1 ) can stimulate melanoma cell migration on VN , presumably by inhibiting uPA / uPAR mediated cell adhesion to VN and thereby releasing the inhibition of cell migration induced by uPA . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the patients and in 10 control subjects , plasma levels of thrombomodulin , beta thromboglobulin , D dimer , tissue type plasminogen activator ( t PA ) and plasminogen activator inhibitor ( PAI 1 ) had previously been measured . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Impaired fibrinolysis due to elevated levels of plasma plasminogen activator inhibitor type 1 ( PAI 1 ) is a risk factor for thromboembolic disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Blood monocytes spontaneously activate endothelial cells in culture , leading to adhesion of monocytic cells onto the endothelial surface and overproduction of endothelial proteins such as von Willebrand factor ( vWf ) and plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Increased expression of plasminogen activator inhibitor 1 ( PAI 1 ) mRNA in atherosclerotic human arteries suggests a linkage between PAI 1 gene expression and cellular proliferation , the fundamental feature of atherosclerosis . ^^^ To investigate whether smooth muscle cell ( SMC ) proliferation influences overall fibrinolytic properties of the vascular wall , we examined the effect of serial in vitro passaging of human SMCs on tissue plasminogen activator ( TPA ) and PAI 1 synthesis levels as well as the ability to modulate TPA and PAI 1 synthesis of human umbilical vein endothelial cells ( HUVECs ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Gene polymorphisms associated with the plasma levels of fibrinogen , factor 7 , and plasminogen activator inhibitor 1 ( PAI 1 ) hemostasis proteins that help to predict the risk of atherothrombotic disease were compared in 124 healthy individuals > or = 100 years old and 130 young , healthy individuals to identify genetic influences on extreme longevity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Sixteen nondiabetic women with polycystic ovary syndrome ( PCOS ) aged 18 to 33 years were studied before and after 8 weeks on metformin ( 1 . 5 g / d ) therapy to assess whether reducing hyperinsulinemia would reduce the levels of the major inhibitor of fibrinolysis , antigenic plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The effect of the proteolytic cleavage of plasminogen activator inhibitor type 1 ( PAI 1 ) by human neutrophil elastase ( HNE ) on fibrinolysis was investigated . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma levels of fibrin D dimer , thrombin antithrombin complex ( TAT ) , plasmin plasmin inhibitor complex ( PPIC ) , soluble fibrin monomer ( sFM ) , prothrombin activated peptide F 1 + 2 ( F 1 + 2 ) , thrombomodulin ( TM ) , tissue type plasminogen activator ( t PA ) , and PA inhibitor ( PAI 1 ) in DIC patients were significantly higher than levels in Non DIC patients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
An abnormality in platelet aggregability or fibrinolysis , namely elevated activity of plasminogen activator inhibitor 1 ( PAI 1 ) , has been recently documented in patients suffering from Klinefelter ' s syndrome associated with leg ulceration without underlying venous insufficiency . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
During the first month after injury , we found that the expression of two proteinase inhibitors ( plasminogen activator inhibitor type 1 [ PAI 1 ] and tissue inhibitor of metalloproteinases 2 [ TIMP 2 ] ) was modulated . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fibrinolytic activity was measured both as plasminogen activator inhibitor type 1 ( PAI 1 ) activity and tissue plasminogen activator ( ( t ) PA ) activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Total fibrinolytic activity , measured on fibrin plates , plasma concentration of tissue type plasminogen activator ( tPA : Ag ) and plasmin alpha 2 antiplasmin complexes ( PAP ) were low , whereas plasminogen activator inhibitor 1 concentration ( PAI 1 : Ag ) was elevated in comparison with normal values . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The activation of plasminogen is regulated by plasminogen activator inhibitor 1 ( PAI 1 ) , plasmin is controlled by alpha 2 plasmin inhibitor . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In patients with restenosis , plasminogen activator inhibitor type 1 ( PAI 1 ) levels were significantly higher ( 88 . 2 + / 36 . 1 vs 118 . 5 + / 50 . 0 ng / dl ; p < 0 . 05 ) and plasmin plasmin inhibitor complex ( PIC ) levels were significantly lower ( 0 . 76 + / 0 . 26 vs 0 . 61 + / 0 . 26 microg / ml ; p < 0 . 02 ) than at baseline . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To determine whether the T cell lymphokines interleukin 4 ( IL 4 ) and interferon gamma ( IFN gamma ) modulate SMC fibrinolysis and migration induced by basic fibroblast growth factor ( bFGF ) , we examined the effects of IL 4 and IFN gamma on human SMC tissue type plasminogen activator ( tPA ) , urokinase type plasminogen activator ( UPA ) , and plasminogen activator inhibitor 1 ( PAI 1 ) antigen production , determined by enzyme linked immunosorbent assays . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Dominant negative Smad 3 , but not other dominant negative Smads , reduced stimulation of the plasminogen activator inhibitor 1 ( PAI 1 ) and other gene promoters by phorbol ester , cAMP , and platelet derived growth factor . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Our study characterized the effect of Hirulog 1 on thrombin induced production of plasminogen activator inhibitor 1 ( PAI 1 ) in cultured baboon aortic smooth muscle cells ( BASMCs ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This assay is based on the ability of TGF beta to induce plasminogen activator inhibitor 1 ( PAI 1 ) expression . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Proinsulin like molecules and plasminogen activator inhibitor type 1 ( PAI 1 ) activity in diabetic and non diabetic subjects with and without myocardial infarction . ^^^ Elevated plasminogen activator inhibitor type 1 ( PAI 1 ) activity has been shown to correlate with plasma insulin , proinsulin like molecules , serum triglycerides and insulin sensitivity in both non insulin dependent diabetic ( NIDDM ) subjects and subjects with coronary heart disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Activation of the renin angiotensin system ( RAS ) can disturb the balance of the fibrinolytic system by stimulating excess production of plasminogen activator inhibitor type 1 ( PAI 1 ) and increasing the risk of thrombotic events . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The function of uPA at this stage was tested using the protease inhibitors aprotinin , alpha 2 antiplasmin , or plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The different components of this system . e . g . urokinase plasminogen activator ( uPA ) , its receptor uPAR , as well as its main inhibitor plasminogen activator inhibitor type 1 ( PAI 1 ) have all been shown to have prognostic value in breast cancer , i . e . high tumor levels are associated with a poor prognosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This increase in TNF alpha contributes to the insulin resistance , elevated plasminogen activator inhibitor 1 ( PAI 1 ) levels , and cardiovascular complications associated with obesity and noninsulin dependent diabetes ( NIDDM ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor type 1 ( PAI 1 ) contributes to the pathogenesis of atherothrombosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
ELISAs for urokinase plasminogen activator ( uPA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) have shown that tumor levels of these molecules are prognostic parameters in breast cancer as well as other types of cancer . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Baseline plasma levels of t PA , plasminogen activator inhibitor 1 ( PAI 1 ) , plasminogen , alpha 2 antiplasmin , fibrinogen , lipoprotein ( a ) , thrombomodulin and von Willebrand factor as well as platelet and leukocyte count and clot retraction were also determined in each donor . rt PA induced clot lysis varied over a wide range ( 28 75 % ) and was significantly related to endogenous t PA , PAI 1 , plasminogen ( p < 0 . 001 ) and age ( p < 0 . 01 ) . ^^^ Multivariate analysis indicated that both PAI 1 antigen and plasminogen independently predicted low response to rt PA . ^^^ Surprisingly , however , not only PAI 1 but also plasminogen was negatively correlated with rt PA induced clot lysis . ^^^ The observation that neutralization of PAI 1 by specific antibodies , both in plasma and within the clot , did not potentiate clot lysis indicates that the inhibitor , including the platelet derived form , is insufficient to attenuate the thrombolytic activity of a pharmacological concentration of rt PA and that its elevation , similarly to the elevation of plasminogen , is not the cause of clot resistance but rather a coincident finding . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) 4G / 5G promoter polymorphism and levels in subjects with cerebrovascular disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In contrast , shear stresses of 6 approximately 24 dynes / cm2 decreased the expression of TNF alpha induced TF in a shear intensity and exposure time dependent manner Tissue plasminogen activator ( t PA ) , which converts plasminogen to plasmin to degrade fibrin clot , and plasminogen activator inhibitor 1 ( PAI 1 ) , which inhibits t PA function , play central roles in fibrinolysis in the endothelium . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The interactions between tPA , alpha 2 macroglobulin ( alpha 2 M ) , and plasminogen activator inhibitor 1 ( PAI 1 ) were investigated both in vitro and in patients undergoing tPA therapy for MI in an attempt to identify variables that might affect the clinical efficacy of tPA . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is a unique member of the serpin superfamily . ^^^ Wild type PAI 1 ( wtPAI 1 ) revealed the same conformational distribution pattern toward tissue type plasminogen activator ( t PA ) as toward urokinase type plasminogen activator ( u PA ) ( i . e . 53 + / 6 . 9 % active , 36 + / 6 . 8 % latent , and 12 + / 1 . 9 % substrate ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Increased expression of urokinase type plasminogen activator ( u PA ) , plasminogen activator inhibitor 1 ( PAI 1 ) , and collagenases in Caco 2 cells infected by Salmonella typhimurium . ^^^ Hypothesizing that the proteases might be provided by host cells , we investigated the changes of expression of urokinase type plasminogen activator ( u PA ) , plasminogen activator inhibitor 1 ( PAI 1 ) , and collagenases in epithelial cells ( Caco 2 ) infected with Salmonella typhimurium . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Endogenous fibrinolytic activity was assessed by measurement of tissue plasminogen activator ( tPA ) and its naturally occurring inhibitor , plasminogen activator inhibitor ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To elucidate the molecular interactions that underlie the interplay between the receptor , RAP , and the ligands , we have analyzed and delineated the binding sites of plasminogen activator inhibitor 1 ( PAI 1 ) , tissue type plasminogen activator ( t PA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We also measured the levels of alpha 2 macroglobulin ( alpha 2M ) and plasminogen activator inhibitor 1 ( PAI 1 ) in blood , and studied their relation to apoE genotypes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
AIM : To study cerebrospinal fluid ( CSF ) concentrations of plasminogen activator inhibitor type 1 ( PAI 1 ) in patients with neurological disease . ^^^ Similarly , there was no association between CSF PAI 1 concentrations and urokinase type plasminogen activator ( uPA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue plasminogen activator ( t PA ) , plasminogen activator inhibitor 1 ( PAI 1 ) , thrombomodulin ( TM ) , von Willebrand factor ( vWF ) , factor 7 , fibrinogen ( FBG ) , FDP , D dimer ( D D ) , plasminogen ( PLG ) , thrombin antithrombin 3 ( TAT ) , alpha 2 plasmin inhibitor / plasmin complex ( PIC ) , antithrombin 3 ( AT 3 ) , protein C , N terminal propeptide for type 3 procollagen ( P 3 P ) , were measured weekly from pre BMT to day 28 after BMT . ^^^ There were no changes in other hemostatic parameters . t PA , PAI 1 and FBG would thus appear useful markers for the diagnosis of VOD , and AT 3 and PLG , predictive markers for VOD . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The aim of work was to study whether activity and antigen level of tissue plasminogen activator ( t PA ) and activity of plasminogen activator inhibitor ( PAI 1 ) were related to severity and extensiveness of vascular lesions in peripheral obliterative atherosclerotic disease ( POAD ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Serial levels of fibrinopeptide A ( FPA ) , fibrinopeptide B beta 15 42 ( FPB beta 15 42 ) , D dimer , tissue plasminogen activator antigen concentration ( t PA antigen ) , t PA activity , plasminogen activator inhibitor 1 antigen concentration ( PAI 1 antigen ) , and PAI 1 activity were determined in 63 patients with out of hospital cardiopulmonary arrest . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Porcine plasminogen activator inhibitor 1 ( poPAI 1 ) cDNA was isolated from a cDNA library prepared from cultured porcine aortic cells and characterized in comparison with PAI 1 cDNA ' s from other species including human , bovine , rabbit , rat and murine . ^^^ The purified recombinant porcine PAI 1 ( rpoPAI 1 ) had a specific activity of 508 , 800 + / 800 U / mg ( mean + / SD , n = 3 ) towards human tissue type plasminogen activator ( ht PA ) and a functional half life in vitro of 2 . 1 + / 0 . 8 h ( n = 3 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Increased levels of plasminogen activator inhibitor type 1 ( PAI 1 ) are thought to potentiate the development of coronary events in this condition . ^^^ Plasma PAI 1 activity , tissue plasminogen activator ( tPA ) activity , levels of fibrinogen and factor 7 ( c ) , and platelet count were measured before and after intervention ( mean+ / SE ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The aim of this study was to investigate the changes of fibrinogen , tissue plasminogen activator ( tPA ) , plasminogen activator inhibitor type 1 ( PAI 1 ) , and lipid levels in continuous ambulatory peritoneal dialysis ( CAPD ) patients with atherosclerosis , and the relationship between those factors and serum albumin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fibrin degradation products ( FbDP ) , D dimer ( DD ) , tissue type plasminogen activator ( t PA ) , and plasminogen activator inhibitor type 1 ( PAI 1 ) were measured as parameters for ongoing fibrinolysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Increased levels of plasminogen activator inhibitor 1 ( PAI 1 ) are a well known risk for cardiovascular diseases . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Preincubation of plasma vitronectin with plasminogen activator inhibitor 1 ( PAI 1 ) , which provoked multimer formation , induced the binding of vitronectin to osteonectin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The present study investigated transcellular signalling mechanism involved in thrombin induced production of plasminogen activator inhibitor 1 ( PAI 1 ) in cultured vascular baboon aortic smooth muscle cells ( BASMC ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have studied the role of plasminogen activator inhibitor 1 ( PAI 1 ) in cell migration , using human amnion WISH cells and human epidermoid carcinoma HEp 2 cells in an assay measuring migration from microcarrier beads and a modified Boyden chamber assay . ^^^ A PAI 1 mutant without ability to inhibit plasminogen activation was as active as wild type PAI 1 as a migration inhibitor , showing that inhibition of plasminogen activation was not involved . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Molecular modeling techniques combined with recently acquired biochemical / biophysical data were used to provide insight into the stable complex formation between plasminogen activator inhibitor 1 ( PAI 1 ) and the target proteinases : tissue type plasminogen activator , urokinase type plasminogen activator , and thrombin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fibrinolysis is regulated in part by the interaction of tissue type plasminogen activator ( t PA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^ In this study , we have significantly extended our earlier observations by identifying t PA variants that are substantially more resistant to inhibition by PAI 1 than any previously reported variants of t PA or urokinase type plasminogen activator . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma levels of tissue plasminogen activator ( TPA ) activity and antigen ( ag ) , plasminogen activator inhibitor ( PAI 1 ) activity at test , and TPA responses to exercise were determined at baseline and after 1 month ' s treatment and were related to subsequent fatal and nonfatal CV events . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue type plasminogen activator ( t PA ) antigen and activity and plasminogen activator inhibitor 1 ( PAI 1 ) antigen and activity were measured in 12 hypertensive ( 69 + / 1 yr ) and 11 normotensive ( 64 + / 1 yr ) men before and after an acute bout of submaximal exercise . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Citrated blood samples were taken from each patient the day before surgery and on postoperative days 1 , 3 , and 7 , before and after venous occlusion , in order to evaluate plasma levels of tissue plasminogen activator ( t PA ) and plasminogen activator inhibitor ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Thrombomodulin ( TM ) , beta thromboglobulin ( beta TG ) , D dimer ( DD ) , tissue type plasminogen activator ( t PA ) , plasminogen activator inhibitor ( PAI 1 ) and quantitative determination of functional protein S ( PS ) were measured using ELISA procedures in the plasma of 16 untreated patients with newly diagnosed deep vein thrombosis in the leg and in 10 healthy volunteers . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Urokinase can form a tripartite complex binding urokinase receptor ( uPAR ) and plasminogen activator inhibitor type 1 ( PAI 1 ) , a component of the extracellular matrix ( ECM ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The plasminogen activator inhibitor type 1 ( PAI 1 ) is often associated with the extracellular matrix . ^^^ Here we investigated whether immobilized plasminogen activator inhibitor type 1 ( PAI 1 ) could regulate cell spreading and cytoskeleton reorganization . ^^^ These data indicate that PAI 1 plays a direct role in dynamic cell adhesion particularly at the leading edge , where increased levels of urokinase plasminogen activator ( uPA ) and its receptor ( uPAR ) are localized in migrating cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A sensitive and robust assay for urokinase and tissue type plasminogen activators ( uPA and tPA ) and their inhibitor type 1 ( PAI 1 ) in breast tumor cytosols . uPA and PAI 1 are becoming established as amongst the most effective markers of poor prognosis for patients with node negative breast cancer ; tPA is an index of longer survival . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Levels of uPA , urokinase plasminogen activator receptor ( uPAR ) and plasminogen activator inhibitor 1 ( PAI 1 ) were measured semiquantitatively in paraffin sections of tumours from 147 patients with NSCLC . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma levels of lipoprotein ( a ) [ Lp ( a ) ] , tissue plasminogen activator ( tPA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) were assessed in addition to anthropometry and levels of glucose , total cholesterol , triglycerides , high density lipoprotein ( HDL ) , low density lipoprotein ( LDL ) and apo A 1 and B in 73 patients ( 36 men and 37 women ) with primary hyperlipidaemia ( group NDHL ) in Kuwait . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Imbalance of tissue type plasminogen activator ( t PA ) and its specific inhibitor ( PAI 1 ) in patients with rheumatoid arthritis associated with disease activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor type 1 ( PAI 1 ) concentrations did not change after low dose Xa / phospholipids , but increased eightfold after high dose Xa / phospholipids , IL 6 pretreatment induced within 8 h a twentyfold increase of PAI 1 but no further increase was observed after injection of factor Xa / phospholipids . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Our aim was to assess the impact of a monounsaturated fat enriched ( Mono ) diet and a diet recommended by the National Cholesterol Education Program ( NCEP ) on plasma levels of fibrinogen and activities of factor 7 ( FVII : C ) and plasminogen activator inhibitor 1 ( PAI 1 ) and the impact of genetic polymorphisms of these variables ( HaeIII , MspI , and 4G / 5G polymorphisms , respectively ) in 28 subjects with impaired glucose tolerance ( [ IGT ] 17 men and 11 women ; mean age , 55 . 6 + / 5 . 5 years ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Therefore , we studied the efficacy of prestorage leucocyte reduction by filtration on total content and extracellular accumulation of histamine , eosinophil cationic protein ( ECP ) , eosinophil protein 10 ( EPX ) , myeloperoxidase ( MPO ) , plasminogen activator inhibitor type 1 ( PAI 1 ) and interleukin 6 ( IL 6 ) in samples obtained from 5 units of SAGM blood , 7 units of plasma reduced whole blood and 6 units of whole blood before and after filtration , respectively . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The plasminogen system , via its triggers , tissue type plasminogen activator ( t PA ) and urokinase type plasminogen activator ( u PA ) and its inhibitor , plasminogen activator inhibitor 1 ( PAI 1 ) , has been implicated in thrombosis , arterial neointima formation , and atherosclerosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Since plasminogen activator inhibitor type 1 ( PAI 1 ) is a major inhibitor of matrix degradation and elevated plasma PAI 1 levels are reported to be associated with increased low density lipoprotein ( LDL ) cholesterol , PAI 1 was examined in the kidneys of rats fed a sodium deficient diet , with or without cholesterol . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This study was undertaken in order to assess whether triglycerides and / or their fatty acids directly influence the secretion of plasminogen activator inhibitor type 1 ( PAI 1 ) in HepG 2 cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Increased plasma plasminogen activator inhibitor type 1 ( PAI 1 ) , coagulation factor 7 ( FVII ) and fibrinogen levels have been recognized as risk factors for cardiovascular disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Previously we revealed that the plasminogen activator inhibitor 1 ( PAI 1 ) gene was being overexpressed in skin fibroblasts from a patient with this syndrome . ^^^ PAI 1 is a potent inhibitor of tissue plasminogen activator and a possible risk factor of atherosclerosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In previous studies we found that colorectal carcinomas have a marked increase of the urokinase type of plasminogen activator ( u PA ) , and the inhibitors PAI 1 and PAI 2 , whereas the tissue type plasminogen activator ( t PA ) is found to be decreased in comparison with adjacent normal mucosa . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Mutational analysis of the genes encoding urokinase type plasminogen activator ( uPA ) and its inhibitor PAI 1 in advanced ovarian cancer . ^^^ Evidence has accumulated that urokinase type plasminogen activator ( uPA ) , its inhibitor ( PAI 1 ) and receptor ( uPAR ) are involved in tumor invasion and metastasis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue type plasminogen activator ( TPA ) and plasminogen activator inhibitor 1 ( PAI 1 ) activity and antigen levels were measured at rest and after a maximal exercise test . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Strong clinical and experimental evidence has accumulated that the tumor associated serine protease plasmin , its activator uPA ( urokinase type plasminogen activator ) , the receptor uPA R ( CD 87 ) , and the inhibitors PAI 1 and PAI 2 are linked to cancer invasion and metastasis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
For both the beta fibrinogen gene and the plasminogen activator inhibitor 1 ( PAI 1 ) gene such functional variations have been described . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Because vitronectin also binds plasminogen activator inhibitor type 1 ( PAI 1 ) , and plasmin cleavage of vitronectin reduces PAI 1 binding , we explored the effects of plasmin and PAI 1 on the interaction between uPAR and vitronectin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Although tissue type plasminogen activator ( tPA ) and plasminogen activator inhibitor 1 ( PAI 1 ) are believed to be involved in the biochemical cascade leading to extracellular matrix degradation during ovulation , the presence and possible role of urokinase type PA ( uPA ) and its receptor ( uPAR ) in follicular wall remodeling during follicular development are poorly understood . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Amino acid sequencing of the amino terminal 28 amino acids showed that it was human plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Human plasminogen activator inhibitor 1 ( PAI 1 ) deficiency : characterization of a large kindred with a null mutation in the PAI 1 gene . ^^^ Plasminogen activator inhibitor 1 ( PAI 1 ) , the primary inhibitor of tissue and urokinase type plasminogen activators , is considered a critical regulator of the fibrinolytic system . ^^^ These observations define the clinical spectrum of PAI 1 deficiency and provide additional evidence to support the hypothesis that the primary function of plasminogen activator inhibitor 1 in vivo is to regulate vascular fibrinolysis . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
One such group , the plasminogen activators ( PAs ) and their inhibitor , PA inhibitor type 1 ( PAI 1 ) , is produced by glomerular cells with altered expression during nephritis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : To investigate the role of plasma neutrophil elastase ( elastase alpha 1 proteinase inhibitor complex ) , plasminogen activator inhibitor 1 ( PAI 1 ) , and disseminated intravascular coagulation ( DIC ) in patients with posttraumatic acute respiratory distress syndrome ( ARDS ) and to explore the time course of the changes of these factors after trauma , we performed a prospective case control study . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The urokinase type plasminogen activator ( u PA ) system consists of the serine proteinases plasmin and u PA ; the serpin inhibitors alpha 2 anti plasmin , PAI 1 and PAI 2 ; and the u PA receptor ( u PAR ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Before and after treatment with troglitazone ( 400 mg daily for 12 weeks ) , all had 1 ) a GnRH agonist ( leuprolide ) test , 2 ) a 75 g oral glucose tolerance test , 3 ) a frequently sampled 4 glucose tolerance test to determine the insulin sensitivity index and the acute insulin response to glucose , 4 ) an oscillatory glucose infusion to assess the ability of the beta cell to entrain to glucose as quantitated by the normalized spectral power for the insulin secretion rate , and 5 ) measures of fibrinolytic capacity [ plasminogen activator inhibitor type 1 ( PAI 1 ) and tissue plasminogen activator ] . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In patients with late restenosis plasminogen activator inhibitor ( PAI 1 ) also increased from 2 . 4 to 4 . 9 U / ml ( P < 0 . 05 ) 24 h after DCA while there were no significant changes in patients without restenosis and in control patients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We investigated the usefulness of the fluorogenic prothrombin time ( FPT ) for detection of hypercoagulability and its association with hyperlipidemia in 19 patients with non insulin dependent diabetes mellitus ( NIDDM ) and 10 healthy control subjects , compared with plasma levels of fibrinogen , plasminogen activator inhibitor 1 ( PAI 1 ) and D dimer . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The urokinase type plasminogen activator ( UPA ) and its inhibitor PAI 1 are thought to play an important part in gastric cancer ( GC ) invasion and metastasis . ^^^ The concomitant activation of UPAR , UPA and PAI 1 in GC confirm the important role of the plasminogen activator system in the process of invasion and metastasis . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have previously reported that notoginsenoside R 1 ( NG R 1 ) increases the synthesis of tissue type plasminogen activator ( t PA ) and decreases plasminogen activator inhibitor 1 ( PAI 1 ) activity in cultured human endothelial cells from different vascular sources . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Here , we tested whether the systemic treatment of mice with kainic acid ( KA ) , an amino acid inducing limbic seizures , could elevate in the brain mRNAs encoding uPA and its specific inhibitor , plasminogen activator inhibitor 1 ( PAI 1 ) , a major antifibrinolytic agent . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Blood samples were measured the levels of blood coagulation factors 7 ( F 7 ) and 10 ( F 10 ) , and plasminogen activator inhibitor 1 ( PAI 1 ) in these subjects , together with the concentrations of serum lipids . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
MEASUREMENTS : ( 1 ) plasma concentrations of plasminogen activator inhibitor 1 antigen ( PAI 1 Ag ) , plasminogen activator inhibitor 1 activity ( PAI 1 activity ) , fibrinogen , von Willebrand factor antigen ( vWF Ag ) , von Willebrand factor activity ( vWF activity ) , and factor 7 activity as pro thrombotic factors ; ( 2 ) plasma concentrations of tissue plasminogen activator antigen ( t PA Ag ) , protein C , and antithrombin 3 as anti thrombotic factors ; ( 3 ) fasting plasma insulin and glucose concentrations , and the lipid pattern ( triglycerides , total and HDL cholesterol ) as metabolic parameters . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A major mechanism for the regulation of extracellular matrix remodelling is via local production of specific proteinase inhibitors , such as the serine proteinase inhibitor plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Derivatives of vitronectin obtained by specific cleavage at its cluster of basic amino acids with thrombin , elastase and plasmin are shown to have a decreased ability to bind plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma levels of tissue plasminogen activator ( t PA ) , plasminogen activator inhibitor 1 ( PAI 1 ) , von Willebrand Factor ( vWF ) , and fibrin D dimer were determined by enzyme linked immunosorbent assays . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In twenty patients with primitive venous hypertension and in ten healthy subjects we have determined the plasmatic levels of : Thrombomodulin ( TM ) , beta Thromboglobulin ( beta TG ) , D Dimer ( DD ) , the tissue activator of the plasminogen ( t PA ) and the inhibitor of the activator of the plasminogen ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Transient co transfection of a luciferase reporter construct ( 3TP Lux ) containing three AP 1 sites and the plasminogen activator inhibitor 1 ( PAI 1 ) promoter , in conjunction with a construct that directs expression of a dominant negative mutant ERK 2 ( TAYF ) protein , did not block the ability of TGFbeta to induce AP 1 or PAI 1 activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the present study we investigated levels of plasminogen activator inhibitor type 1 ( PAI 1 ) and urokinase plasminogen activator receptor ( uPAR ) , as quantitated by ELISA in tumour extracts from 64 NSCLC patients ( 38 squamous cell carcinomas , 26 adenocarcinomas ) , and compared them to staining intensity as semiquantitated by immunohistochemistry for PAI 1 and uPAR on corresponding cryostat sections . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Using in situ hybridization with digoxigenin labelled cRNA probes ( dig cRNA ) , we demonstrated that tPA and plasminogen activator inhibitor type 1 ( PAI 1 ) were expressed in testes of both immature and mature rhesus monkeys . tPA mRNA was localized predominantly in Sertoli cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To investigate the mechanism of this decrease , we studied the regulation of plasminogen activator inhibitor 1 ( PAI 1 ) , tissue type plasminogen activator ( TPA ) , tissue factor ( TF ) , and tissue factor pathway inhibitor ( TFPI ) by angiotensin 2 ( Ang 2 ) in cultured rat aortic endothelial cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma levels of plasminogen activator inhibitor 1 ( PAI 1 ) activity and PAI 1 antigen and tissue plasminogen activator ( TPA ) antigen were measured before randomization and on day 14 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
RESULTS : In both mild and severe preeclampsia , the mean plasma concentrations of thrombin antithrombin 3 complex ( TAT ) and plasminogen activator inhibitor type 1 ( PAI 1 ) activity were significantly increased , while fibrinogen , antithrombin 3 ( ATIII ) and plasminogen activator inhibitor type 2 ( PAI 2 ) antigen levels were significantly reduced compared to controls . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) cDNA was expressed in Escherichia coli ( E . coli ) with high efficiency using a heat inducible vector . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We measured the antigen levels of urokinase type plasminogen activator ( u PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) in tissue extracts from nasopharyngeal carcinomas . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In breast cancer , several investigations have demonstrated that the tumour biological factors uPA urokinase type plasminogen activator ) and its inhibitor PAI 1 are statistically independent , strong prognostic factors for disease free ( DFS ) and overall survival ( OS ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The aim of this study was to evaluate the antithrombotic potential of T 686 ( ( 3E , 4E ) 3 benzylidene 4 ( 3 , 4 , 5 trimethoxy benzylidene ) pyrr olidine 2 , 5 dione ) , a novel inhibitor of plasminogen activator inhibitor 1 ( PAI 1 ) , in rat thrombosis models . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
When HUVECs were conditioned with AS 4 , a dose ( 0 . 01 100 microg AS IV / ml ) and time dependent decrease in plasminogen activator inhibitor type 1 ( PAI 1 ) and an increase in tissue type plasminogen activator ( t PA ) synthesis were observed , which were significant from 1 microg AS IV / ml and from 12 h of incubation with 100 microg AS IV / ml . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
At the onset of AMI , plasma levels of tissue type plasminogen activator ( t PA ) , PA inhibitor 1 ( PAI 1 ) , fibrin D dimer , thrombin antithrombin complex ( TAT ) , and plasmin plasmin inhibitor complex ( PPIC ) were significantly increased . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
All subjects were tested on the following parameters : fibrinogen , factor 7 , prothrombin fragment 1 + 2 ( F 1 + 2 ) , thrombin antithrombin 3 complexes ( TAT ) , tissue plasminogen activator ( t PA ) antigen ( Ag ) before and after venous occlusion ( VO ) , and plasminogen activator inhibitor type 1 ( PAI 1 ) activity pre and post VO . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Epidemiologial studies suggest that elevated plasma plasminogen activator inhibitor 1 ( PAI 1 ) activity is associated with ischaemic heart disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fibrinolysis , the process to remove fibrin in tissues , is initiated by tissue type plasminogen activator ( tPA ) and suppressed by type 1 plasminogen activator inhibitor ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Clearance of tissue plasminogen activator ( TPA ) and TPA / plasminogen activator inhibitor type 1 ( PAI 1 ) complex : relationship to elevated TPA antigen in patients with high PAI 1 activity levels . ^^^ BACKGROUND : To evaluate the effect of plasminogen activator inhibitor type 1 ( PAI 1 ) levels on the clearance of total tissue plasminogen activator ( TPA ) antigen , we studied the clearance of active TPA and TPA / PAI 1 complex in subjects with low ( 181+ / 109 pmol / L ; n=7 ) and high ( 1166+ / 322 pmol / L ; n=4 ) baseline active PAI 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : Elevated levels of plasminogen activator inhibitor 1 ( PAI 1 ) have been associated with the occurrence of thrombotic disease , and inhibition of PAI 1 activity in vivo resulted in enhanced thrombolysis and a reduction in reocclusion . ^^^ XR 5118 selectively and competitively inhibited binding of the PAl 1 inhibiting monoclonal antibody CLB 2C8 , indicating that binding of XR 5118 to PAI 1 takes place at the area between amino acids 110 and 145 of the PAI 1 molecule , which is known to be involved with the binding of PAI 1 to tissue plasminogen activator ( TPA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The levels of plasminogen activator urokinase ( uPA ) and of its inhibitor ( PAI 1 ) were measured by use of ELISA in the cytosol of tissue homogenates obtained from endometrial carcinomas and the marginal , tumor free endometrium of postmenopausal patients ( n = 64 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Total homocysteine ( tHcy ) concentrations in culture media as a measure of homocysteine export increased in all cell lines , including the cell line with CS deficiency , with constant amounts of approximately 2 . 5 microM every 24 h . von Willebrand factor ( vWF ) , tissue plasminogen activator ( tPA ) and plasminogen activator inhibitor ( PAI 1 ) in culture media were used as markers of endothelial function and increased also with progression of culture time . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Impaired fibrinolysis , resulting from increased plasminogen activator inhibitor 1 ( PAI 1 ) or reduced tissue type plasminogen activator ( t PA ) plasma levels , may predispose the individual to subacute thrombosis in sepsis and inflammation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVES : To evaluate the effect of therapeutic and pharmacologic concentrations of two non steroidal anti inflammatory drugs ( NSAIDs ) , nimesulide and naproxen , on the synthesis of urokinase ( uPA ) , plasminogen activator inhibitor ( PAI 1 ) and interleukin 6 ( IL 6 ) in human synovial fibroblasts isolated from osteoarthritis ( OA ) patients . ^^^ The suppressive action of the two drugs on the synthesis of uPA , while stimulating PAI 1 production , may have a positive impact on the balance of plasminogen activator / inhibitor , which could help reduce cartilage catabolism . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is not related to response to neoadjuvant chemotherapy in breast cancer . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We investigated the time course and localization of ovarian tissue type plasminogen activator ( tPA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) expression during the ovulatory period in rat by RNase protection assay and in situ hybridization . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) content in platelets from healthy individuals genotyped for the 4G / 5G polymorphism in the PAI 1 gene . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Quantitative reverse transcription polymerase chain reaction and in situ hybridization were employed to investigate the expression of tissue type and urokinase type plasminogen activators ( t PA and u PA , respectively ) , of their specific inhibitor ( PAI 1 ) , and of the procoagulant molecule tissue factor ( TF ) in tissues from mice that develop autoimmune disease ( MRL lpr / lpr ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A defect in the fibrinolytic system results from an increase in type 1 plasminogen activator inhibitor ( PAI 1 ) in diabetes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The trandolapril group did not differ significantly from the placebo group with respect to AUC 1 12 t PA antigen [ 11 . 67 ( 3 . 95 26 . 45 ) versus 10 . 34 ng / ml ( 3 . 71 19 . 62 ) , P = 0 . 19 ] and AUC 1 12 plasminogen activator inhibitor type 1 ( PAI 1 ) antigen [ 27 . 57 ( 8 . 38 89 . 49 ) versus 24 . 40 ng / ml ( 7 . 94 90 . 62 ) , P = 0 . 92 ] . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : Using Northern blot analysis , in situ hybridization , and immunohistochemistry , the expression of uPA , its receptor ( uPAR ) , plasminogen activator inhibitor 1 ( PAI 1 ) , and transforming growth factor beta 1 ( TGF beta 1 ) was studied in 14 patients undergoing pancreatic resection for CP . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The interaction of thrombin with plasminogen activator inhibitor 1 ( PAI 1 ) is shown to result in the simultaneous formation of both cleaved PAI 1 and a sodium dodecyl sulfate stable thrombin PAI 1 complex . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To investigate the relationship between plasminogen activator ( PA ) , plasminogen activator inhibitor 1 ( PAI 1 ) and the extracellular matrix in malignant and normal lung epithelial cells and to determine whether malignant lung epithelial cells may be more invasive than normal lung epithelial cells because of differences in expression of these proteins in response to TGF beta , the regulation of PA , PAI 1 , fibronectin , laminin and thrombospondin by TGF beta 1 in human non small cell lung cancer ( NSCLC ) cells was examined and compared with normal human bronchial epithelial ( NHBE ) cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The aim of study was the evaluation of tissue plasminogen activator ( t PA ) and its inhibitor ( PAI 1 ) in the 2 type diabetes on the base of the common fibrinolytic system tests as euglobulin lysis time ( ELT ) and the concentration of fibrin / fibrinogen products ( FDP ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
C . 3 . 4 . 21 . 68 ) and plasminogen activator inhibitor type 1 ( PAI 1 ) are still not fully elucidated . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We investigated in human umbilical vein endothelial cells ( HUVECs ) the interaction between the signaling pathways triggered by calcium mobilization and those affected by human recombinant tumor necrosis factor alpha ( TNF ) on the expression of type 1 plasminogen activator inhibitor ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the primary cancers , PAI 2 levels correlated weakly but significantly with those of uPA and PAI 1 , but not with tissue type plasminogen activator ( tPA ) or uPA receptor ( uPAR ) levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In 587 frozen samples of malignant and nonmalignant tissue of breast , uterus , vulva , and ovary , levels of urokinase plasminogen activator ( uPA ) , tissue plasminogen activator ( tPA ) , and plasminogen activator inhibitor 1 ( PAI 1 ) were examined with enzyme linked immunosorbent assay ( ELISA ) and cathepsin D ( cath D ) with radioimmunoassay . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is the primary physiological inhibitor of both tissue type plasminogen activator ( t PA ) and urokinase type plasminogen activator ( u PA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This study characterizes the expression of tissue type plasminogen activator ( TPA ) , urokinase type plasminogen activator ( UPA ) , and plasminogen activator inhibitor 1 ( PAI 1 ) in hyperplastic vein grafts and normal venous tissue . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : We examined the patterns of expression of urokinase type plasminogen activator ( u PA ) , tissue type plasminogen activator ( t PA ) , plasminogen activator inhibitor 1 ( PAI 1 ) , and vitronectin in head and neck squamous cell carcinomas using immunohistochemical techniques . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Inhibition of metastasis of intraocular melanomas by adenovirus mediated gene transfer of plasminogen activator inhibitor type 1 ( PAI 1 ) in an athymic mouse model . ^^^ A replication deficient adenovirus vector was used for the in vivo transfer of plasminogen activator inhibitor type 1 ( PAI 1 ) cDNA . ^^^ Intraocular injection of an adenovirus vector ( AdCMV PAI 1 ) expressing plasminogen activator inhibitor 1 resulted in : ( 1 ) the transduction of more than 95 % of human and murine uveal melanoma cells in the eyes of nude mice ; ( 2 ) a 50 % reduction in the number of animals developing liver metastases ; and ( 3 ) a 78 % reduction in the metastatic tumor burden in animals that eventually developed metastases . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
There were no significant differences between athletes and controls in plasminogen activator inhibitor 1 ( PAI 1 ) and thrombin antithrombin complex ( TAT ) levels at rest . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Global fibrinolytic activity ( euglobulin fraction , fibrin plate assay ) , tissue plasminogen activator ( tPA ) antigen ( Ag ) and activity ( Act ) , plasminogen activator inhibitor 1 ( PAI 1 ) Ag and Act , alpha 2 antiplasmin plasmin complexes , and von Willebrand factor ( vWF ) antigen were assayed . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS AND RESULTS : The tests of fibrinolysis ( serum levels of fibrinogen , D dimers , tissue plasminogen activator ( tPA ) and plasminogen inhibitor 1 ( PAI 1 ) and circulating cytoadhesive molecules ( sE selectin , sP selectin and ICAM 1 ) were followed in a group of 66 pregnant women and compared with the unpaired Student ' s t test with a group of 16 women after uncomplicated ovarectomy for benign disease . ^^^ There were significant correlations between serum levels of 17 beta estradiol fibrinogen ( r = 0 . 46 , p < 0 . 01 ) , plasminogen activator 1 ( PAI 1 ) ( r = 0 . 38 ) and tissue plasminogen activator 1 ( tPA ) ( r = 0 . 22 , p < 0 . 05 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Induction of tissue type plasminogen activator ( tPA ) and type 1 plasminogen activator inhibitor ( PAI 1 ) as early growth responses in rat hepatocytes in primary culture . ^^^ Early growth response with respect to tissue type plasminogen activator ( tPA ) and type 1 plasminogen activator inhibitor ( PAI 1 ) gene expression was studied in rat hepatocytes in primary culture . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Both have been shown to mediate endocytosis and degradation of complex between plasminogen activators and type 1 plasminogen activator inhibitor ( PAI 1 ) by cultured cells . ^^^ We have now studied the specificity of binding and endocytosis by VLDLR and alpha2MR / LRP among a variety of serine proteinase / serpin complexes , including various combinations of the serine proteinases urokinase type and tissue type plasminogen activators , plasmin , thrombin , human leukocyte elastase , cathepsin G , and plasma kallikrein with the serpins PAI 1 , horse leukocyte elastase inhibitor , protein C inhibitor , C 1 inhibitor , alpha 2 antiplasmin , alpha 1 proteinase inhibitor , alpha 1 antichymotrypsin , protease nexin 1 , heparin cofactor 2 , and antithrombin 3 . ^^^ We found that the receptors bind with high affinity to some , but not all , combinations of plasminogen activators and thrombin with PAI 1 , protease nexin 1 , protein C inhibitor , and antithrombin 3 , while complexes of many serine proteinases with their primary inhibitor , i . e . plasmin / alpha2 antiplasmin complex , do not bind , or bind with a very low affinity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The conversion of plasminogen to plasmin by plasminogen activators ( PAs ) is controlled by their specific inhibitor , PAI 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue plasminogen activator , D dimer and plasminogen activator inhibitors ( PAI 1 and PAI 2 ) were determined . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma levels of tissue type plasminogen activator ( t PA ) , plasminogen activator inhibitor 1 ( PAI 1 ) and von Willebrand factor ( vWF ) were measured by enzyme linked immunosorbent assays . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) , a member of the serpins , has a unique conformational flexibility . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) antigen plasma levels in subjects attending a metabolic ward : relation to polymorphisms of PAI 1 and angiontensin converting enzyme ( ACE ) genes . ^^^ Plasminogen activator inhibitor 1 ( PAI 1 ) is a determinant of vascular events . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Immunoelectron microscopic localization of plasminogen activator inhibitor type 1 ( PAI 1 ) in smooth muscle cells from morphologically normal and atherosclerotic human arteries . ^^^ The major physiologic inhibitor of t PA and u PA is plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Differential regulation of the plasminogen activator inhibitor 1 ( PAI 1 ) gene expression by growth factors and progesterone in human endometrial stromal cells . ^^^ Plasminogen activator inhibitor 1 ( PAI 1 ) has important regulatory functions in haemostasis , extracellular matrix turn over and cell adhesion . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Furthermore , dialysate concentrations of thrombin antithrombin 3 ( TAT ) complexes ( indicator of thrombin formation ) , D dimers ( indicator of fibrinolysis ) , and plasminogen activator inhibitor 1 ( PAI 1 ) were measured . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In a group of 13 patients with obliterative arteriopathies of the lower limbs the plasma levels of thrombomodulin ( TM ) , betathromboglobulin ( beta TG ) , D dimer ( DD ) and plasminogen activator inhibitor ( pAI 1 ) were measured , and compared to the values obtained from 10 healthy volunteers . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : We examined the relationships among vitronectin ( VN ) , plasminogen activator inhibitor 1 ( PAI 1 ) , and transforming growth factor beta 1 ( TGF beta 1 ) in liver diseases to evaluate the presence of plasmin cascade in human hepatic fibrosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fibrinogen , vWF , plasminogen , ECLT , a 2 antiplasmin , tPA Ag , PAI 1 in all pts and in the control group were measured . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Using human platelet rich plasma , P selectin expression was measured by flow cytometry and type 1 plasminogen activator inhibitor ( PAI 1 ) secretion as well as beta thromboglobulin ( beta TG ) were determined by ELISA . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We sought to learn more about this variability by examining the effects of gemfibrozil and ciprofibrate on plasma levels of tissue type plasminogen activator ( t PA ) , plasminogen activator inhibitor 1 ( PAI 1 ) and fibrinogen in primary hyperlipidaemic patients after six and twelve weeks of treatment using different assay systems for PAI 1 and fibrinogen . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Ex vivo platelet aggregation , activities and concentrations of tissue type plasminogen activator ( t PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) were measured before , 90 and 150 minutes after drug intake . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The tissue distribution of uPA , tPA , uPA receptor ( uPAR ) , and plasminogen activator inhibitor type 1 ( PAI 1 ) was studied by immunohistochemistry . uPA , tPA , uPAR , and PAI 1 mRNA values and mRNA distribution were assessed by northern blot and in situ hybridisations respectively . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This study was performed to compare measurements of the enzymatic components of the intrinsic fibrinolytic system ( tissue plasminogen activator [ tPA ] , plasminogen activator inhibitor [ PAI 1 ] ) with the observed morphologic changes in thrombosed venous segments using venous duplex ultrasound scanning ( VDUS ) at intervals after diagnosis of acute DVT . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In addition , overexpression of specific Smad combinations can mimic the transcriptional effect of TGF beta on both the plasminogen activator inhibitor 1 ( PAI 1 ) promoter and the reporter construct p3TP Lux . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The serpin plasminogen activator inhibitor 1 ( PAI 1 ) , an important risk factor for thrombotic disease can be neutralized by distinct mechanisms . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The effects of different flavonoids isolated from the roots of Scutellaria baicalensis Georgi on the production of tissue type plasminogen activator ( t PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) induced by thrombin and thrombin receptor agonist peptide , Ser Phe Leu Leu Arg Asn Pro Asn Asp Lys Tyr Glu Pro Phe , have been examined in cultured human umbilical vein endothelial cells ( HUVECs ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A Smad 3 protein in which the three C terminal serines have been replaced by aspartic acids is also a dominant inhibitor of TGF beta signaling , but can activate plasminogen activator inhibitor 1 ( PAI 1 ) transcription in a ligand independent fashion when its nuclear localization is forced by transient overexpression . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Transplant patients had higher insulin ( 35 + / 3 vs 24 + / 3 microIU / L ) , fibrinogen ( 298 + / 15 vs 261 + / 14 mg / dl ) , and plasminogen activator inhibitor 1 ( PAI 1 ) ( 17 + / 2 vs 11 . 7 + / 2 arbitrary units / ml ) plasma levels than controls . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The aim of this study was to know if lipoproteins , fibrinogen , plasminogen activator inhibitor 1 ( PAI 1 ) and platelet aggregation show more abnormalities in renal transplant patients with CRAD than in those with stable renal function . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
MC were found to react with antibodies against tissue type plasminogen activator ( tPA ) and urokinase receptor ( uPAR / CD87 ) , but not with antibodies against urokinase ( uPA ) or plasminogen activator inhibitors ( PAI 1 , PAI 2 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Therefore , we studied the consequences of plasminogen activator inhibitor 1 ( PAI 1 ) gene inactivation and adenoviral PAI 1 gene transfer on arterial neointima formation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : Insulin resistant states are characterized by accelerated atherosclerosis and are associated with increased plasma concentrations of insulin and plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The effects of a soluble NSP ( fibre ) concentrate ( SFC ) on plasma fibrinogen and plasminogen activator inhibitor 1 ( PAI 1 ) , serum and liver lipids and lipoproteins and glucose tolerance were compared with those of bezafibrate ( BF ) , a lipid lowering drug , in obese baboons ( Papio ursinus ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Samples for enzyme linked immunosorbent assay or radioimmunoassay analyses of histamine , myeloperoxidase ( MPO ) , eosinophil cationic protein ( ECP ) , and plasminogen activator inhibitor 1 ( PAI 1 ) were drawn from the units at donation , after 7 days of storage just before transfusion , and during the in vitro transfusion . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : The 4G allele of the 4G / 5G polymorphism in the promoter of the plasminogen activator inhibitor ( PAI 1 ) gene is associated with increased PAI 1 activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The type 1 inhibitor of plasminogen activator ( PAI 1 ) is a major physiologic regulator of pericellular proteolytic activity and , as such , influences matrix integrity , cell to substrate adhesion , and cellular proliferation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Cytokine mediated regulation of rat ovarian function : interleukin 1 inhibits plasminogen activator activity through the induction of plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Enhanced invasion was not associated with significant changes in the expression of uPA or its membrane receptor UPAR ; plasminogen activator inhibitors PAI 1 and PAI 2 ; metalloproteinases MMP 1 , MMP 2 , MMP 3 , MMP 9 and membrane type MMP 1 ; or tissue inhibitors of metalloproteinases TIMP 1 and TIMP 2 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fibrinogen , factor 7 coagulant activity , von Willebrand factor ( vWf ) antigen , and plasminogen activator inhibitor 1 ( PAI 1 ) activity were measured in 46 adult participants in the Arterial Disease Multiple Intervention Trial ( ADMIT ) and in 76 control subjects and related to ankle brachial systolic pressure index ( ABI ) , a measure of lower limb arterial stenosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Both plasminogen activator inhibitor 1 ( PAI 1 ) binding and activity were increased on glycated fibrin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Quantitative immunoreactive assays for tissue type plasminogen activator ( t PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) in the culture media indicated that OSF ( 25 micrograms / ml ) increased the accumulation of PAI 1 antigen , but not of t PA antigen , 2 . 7 fold compared with control . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The system is controlled by a series of plasminogen activator inhibitors ( PAIs ) , most importantly PAI 1 and PAI 2 , providing means of temporally restricting the process of plasminogen activation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the circulation , fibrinolytic activity is determined to a large degree by the relative levels of tissue plasminogen activator ( tPA ) and its major inhibitor ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The complex of the type 1 plasminogen activator inhibitor ( PAI 1 ) and its target proteinases , the urokinase and tissue type plasminogen activators ( uPA and tPA ) , but not the free components , bind with high affinity to the endocytosis receptors alpha 2 macroglobulin receptor / low density lipoprotein receptor related protein ( alpha2MR / LRP ) and very low density lipoprotein receptor ( VLDLR ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Using a pregnant mare serum gonadotropin ( PMSG ) / human chorionic gonadotropin ( hCG ) induced rhesus monkey corpus luteum ( CL ) model , we have studied how urokinase type plasminogen activator ( uPA ) , tissue type plasminogen activator ( tPA ) , and plasminogen activator inhibitor type 1 ( PAI 1 ) , are temporally expressed in CL of rhesus monkey at the luteotropic and luteolytic periods . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The following endothelium derived proteins were measured as markers of endothelial cell function : von Willebrand factor ( vWf ) and von Willebrand factor propeptide ( vWf : AgII ) , tissue type plasminogen activator ( tPA ) , plasminogen activator inhibitor 1 ( PAI 1 ) , cellular fibronectin ( cFN ) and thrombomodulin ( TM ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Both genes and environmental factors have been reported to influence plasma levels of plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The oral estrogen group was associated with a significant decrease in both mean tissue type plasminogen ( t PA ) concentration and plasminogen activator inhibitor ( PAI 1 ) activity and a significant rise in global fibrinolytic capacity ( GFC ) compared with the two other groups . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The hypothesized relationships between plasminogen activator inhibitor ( PAI 1 ) genotypes , PAI 1 levels , and their potential regulation by hypertriglyceridemic ( HTG ) very low density lipoprotein ( VLDL ) and lipoprotein ( a ) [ Lp ( a ) ] was examined in a PAI 1 genotyped human umbilical vein endothelial cell ( HUVEC ) culture model system . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
It has been shown that Ang 2 modulates fibrinolysis , that is , Ang 2 increases plasminogen activator inhibitor 1 ( PAI 1 ) mRNA and plasma PAI 1 levels in vitro and in vivo . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activators ( PAs ) and their inhibitor , plasminogen activator inhibitor type 1 ( PAI 1 ) , have been implicated in modulation of luminal fibrinolysis and mural proteolysis contributing to atherogenesis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The expression of uPA , activators of uPA ( cathepsin D , antithrombin 3 ) , uPA substrates ( plasminogen , matrix metalloproteinase 2 [ collagenase 4 , 72 kD ; MMP 2 ] ) , uPA / plasmin inhibitors ( plasminogen activator inhibitor type 1 and 2 [ PAI 1 , PAI 2 ] , alpha 1 antitrypsin , alpha 2 antiplasmin ) , uPA receptor ( uPA R ) , and parameters of the uPA R cycle ( alpha 2 macroglobulin , alpha 1 antichymotrypsin ) could be determined immunohistochemically and were scored semiquantitatively in 203 patients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We therefore investigated the inhibitory effect of TNP 470 on cancer cell proliferation , and the suppressive effect of TNP 470 on urokinase type plasminogen activator ( u PA ) and its inhibitor ( PAI 1 ) , in human lung cancer cell lines in vitro . ^^^ Unchanged serum levels of u PA and PAI 1 would be of great advantage to the diseased patients , since the plasminogen activator system has a crucial function in the process of distant metastasis . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Euglobulin lysis time , tissue type plasminogen activator and plasminogen activator inhibitor 1 ( PAI 1 ) activities , and antigens were determined before and after the venous occlusion test . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This latter inhibitory capacity was the result of a significant increase in plasminogen activator inhibitor type 1 ( PAI 1 ) , given its abolition by a polyclonal anti rat PAI 1 immunoglobulin G . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Small , dense LDL particle concentration correlates with plasminogen activator inhibitor type 1 ( PAI 1 ) activity . ^^^ Apolipoprotein B ( apoB ) concentration in the most dense LDL 5 ( r = 0 . 39 , p < 0 . 001 ) and LDL 6 ( r = 0 . 43 , p < 0 . 001 ) subfractions associated with plasminogen activator inhibitor type 1 ( PAI 1 ) activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the present study we have analyzed the relationship between coagulation inhibitors ( antithrombin 3 , protein C and S , thrombomodulin ) , liver function impairment , and plasma activity of the endothelium derived proteins plasminogen activator ( t PA ) and plasminogen activator inhibitor ( PAI 1 ) in 27 alcoholic cirrhotic patients and 25 controls . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Circulating concentrations of plasminogen activator inhibitor 1 ( PAI 1 ) , factor 7 and fibrinogen have all been related to vascular risk in large prospective studies . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Limited and directed proteolysis regulated by plasminogen activator ( PA ) , plasminogen activator inhibitor type 1 ( PAI 1 ) and other related factors may play an essential role in these processes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The following factors were measured : tissue plasminogen activator ( t PA ) , plasminogen activator inhibitor 1 ( PAI 1 ) , plasmin alpha 2 plasmin inhibitor complex ( PIC ) , stabilized fibrin degradation product ( D dimer ) , and von Willebrand factor antigen determined by enzyme immunoassay , and endothelin 1 by radioimmunoassay with two antibodies . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have examined the effects of an inhibitor of plasminogen activator inhibitor 1 ( PAI 1 ) production , ( 3E , 4E ) 3 benzylidene 4 ( 3 , 4 , 5 trimethoxy benzylidene ) pyrrol idine 2 , 5 dione ( T 686 ) , on lipopolysaccharide ( LPS ) induced death in mice . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Arterial and venous plasma levels of plasminogen activator inhibitor 1 ( PAI 1 ) antigen and activity were higher in BH subjects ( P < or = . 05 throughout ) , who in contrast to NC subjects , also had a significant forearm net release of PAI 1 antigen ( P = . 006 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Triglyceride rich lipoproteins may attenuate fibrinolysis by increasing the plasma levels of plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Increased plasma plasminogen activator inhibitor 1 ( PAI 1 ) concentration has been identified as a risk factor for coronary heart disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) , a member of the urokinase type plasminogen activator ( uPA ) system , can already be defined as an established new prognostic factor in gastric cancer . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Application of a model to the latent plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^ Mutants of a protease inhibitor , plasminogen activator inhibitor type 1 ( PAI 1 ) , containing one or two cysteine residues , were labeled with sulfhydryl specific derivatives of 4 , 4 difluoro 4 borata 3a azonia 4a aza s indacence ( BODIPY ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
All doses of r hirudin prevented decreases in tissue plasminogen activator ( t PA ) and reduced the increase in plasminogen activator inhibitor 1 ( PAI 1 ) activity observed at 2 hours after endotoxin administration . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue plasminogen activator ( t PA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) play important role in regulation of fibrinolysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue and urokinase plasminogen activators ( t PA , u PA ) and their inhibitor PAI 1 in blood of patients with laryngeal neoplasms ] . ^^^ In this study we measured the concentrations of tissue plasminogen activator ( t PA ) , urokinase plasminogen activator ( u PA ) , activity of plasminogen activator inhibitor type 1 ( PAI 1 ) and euglobulin lysis time ( ELT ) in the blood of 20 men aged 42 75 years old with planoepitheliale larynx carcinoma , and 10 healthy persons in similar age . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In fact , in PC 3 and DU 145 cells but not in LNCaP cells , urokinase type plasminogen activator ( uPA ) and plasminogen activator inhibitor 1 ( PAI 1 ) are induced by bombesin treatment . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This study was conducted to determine whether prolactin ( PRL ) suppresses gonadotrophin induced ovulation and disturbs the co ordinated gene expression of tissue type plasminogen activator ( tPA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) in rat ovary . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Therefore , we analysed the relationships between free T 4 ( fT 4 ) levels and Factor 7 and 8 activities ( FVIIc and FVIIc ) , D Dimers ( DDI ) and Plasminogen Activator Inhibitor type 1 ( PAI 1 ) , in a group of 472 healthy patients referred for hyperlipidemia . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Consecutive tissue cryosections of 51 adenomas , 49 distant mucosa samples and five mucosa samples from control subjects were histopathologically analysed for dysplasia grade and tissue type , urokinase plasminogen activator levels and plasminogen activator inhibitor type 1 ( PAI 1 ) using immunosorbent methods . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : We evaluated plasminogen activator inhibitor 1 ( PAI 1 ) , factor 7 activity ( FVII ) , and fibrinogen in a sample of octo nonagenarians . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In HBECs , TGF beta 1 inhibited cell proliferation and uPA activity , while it augmented plasminogen activator inhibitor 1 ( PAI 1 ) antigen level . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma concentrations of tissue type plasminogen activator ( t PA ) , plasminogen activator inhibitor type 1 ( PAI 1 ) , and D dimer were investigated in 50 patients treated intravenously for acute myocardial infarction with either streptokinase ( n = 23 ) , urokinase ( n = 17 ) , or recombinant t PA ( rt PA , n = 10 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
After ACEI administration the renin secretion increased and the levels of the plasminogen activator inhibitor ( PAI 1 ) did not change . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A novel low molecular weight inhibitor , AR H029953XX , was developed from a known fibrinolytic compound , flufenamic acid , which prevented complex formation of human plasminogen activator inhibitor type 1 ( PAI 1 ) with tissue plasminogen activator ( tPA ) by inhibition of PAI 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma levels of plasminogen activator inhibitor 1 ( PAI 1 ) modulate this risk . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Increased levels of plasminogen activator inhibitor 1 ( PAI 1 ) have been discussed as a part of the insulin resistance syndrome . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The plasminogen activator inhibitor type 1 ( PAI 1 ) gene encodes the physiological inhibitor of tissue type and urokinase type plasminogen activators and is induced by cytokines such as transforming growth factor beta ( TGF beta ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
EC inhibition of TGF beta 1 activation could be blocked with plasminogen activator inhibitor 1 ( PAI 1 ) antibody . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The two fucosylated FG 2 Fc chimeras were compared with each other , with non fucosylated FG and with intact t PA with regard to their effect on the clearance of t PA and t PA 10 plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Insensitivity to plasminogen activator inhibitor 1 ( PAI 1 ) and the presumed lack of free plasminogen in serum free culture media argued against plasmin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Various coagulation analytes including antithrombin 3 ( ATIII ) activity , protein C activity , protein S activity , alpha 2 antiplasmin activity , anticardiolipin antibodies ( aCL ) , plasminogen activator inhibitor ( PAI 1 ) activity and tissue type plasminogen activator ( tPA ) antigen were measured using citrated plasma samples from the patients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Blood samples were collected from the circuits before the start of the perfusion and at 0 . 5 , 1 , 3 , 12 , and 24 h of perfusion , and analysed for platelet count , plasma betathromboglobulin ( beta TG ) , platelet membrane glycoprotein ( GP ) Ib and GPIIb / IIIa expression , thrombin / antithrombin 3 complex ( TAT ) , prothrombin fragment 1+2 ( F1+2 ) , fibrinogen , D dimer , and plasminogen activator inhibitor 1 activity ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Serosal fibrinolysis is regulated by mesothelial release of tissue type plasminogen activator ( t PA ) and plasminogen activator inhibitor types 1 and 2 ( PAI 1 and PAI 2 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Several studies have linked higher plasma fibrinogen and plasminogen activator inhibitor ( PAI 1 ) concentrations with increased risk of cardiovascular disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In invasive but not in intraductal regions , especially those with abundant stroma , plasminogen activator inhibitor 1 ( PAI 1 ) mRNA was observed in cancer cells , fibroblasts , macrophages , and endothelial cells , and PAI 2 mRNA was present in cancer cells , and fibroblasts , macrophages , and lymphocytes around them . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
MAIN OUTCOME MEASURE ( S ) : Euglobulin clot lysis times , plasminogen activator inhibitor 1 ( PAI 1 ) activity , fibrinogen , plasminogen , and alpha 2 antiplasmin concentrations in plasma . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Much of the controversy surrounding the binding of plasminogen activator inhibitor 1 ( PAI 1 ) to the low density lipoprotein receptor related protein ( LRP ) may be due to the labile structure of PAI 1 and the distinct conformations that it can adopt . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
High plasma plasminogen activator inhibitor 1 ( PAI 1 ) activity is a frequent finding in obesity , and both PAI 1 and obesity are risk factors for cardiovascular disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Increased concentrations of plasminogen activator inhibitor type 1 ( PAI 1 ) in blood and attenuated fibrinolytic activity , hypertriglyceridaemia , and insulin resistance are common in subjects with obesity and non insulin dependent diabetes mellitus who are at markedly increased risk for coronary artery disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the acute phase , intense plasminogen activator inhibitor 1 ( PAI 1 ) gene expression was apparent in areas interfacing the dissecting hematoma , but no tissue type PA ( t PA ) , urokinase type PA ( u PA ) , or MMP 9 mRNAs were detected . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
These include a reduced proliferative capacity , an altered size and shape , the presence of underphosphorylated retinoblastoma protein ( pRb ) , increased expression of plasminogen activator inhibitor ( PAI 1 ) and the appearance of senescence associated beta galactosidase ( SA beta gal ) activity [ 2 , 3 , 13 15 ] . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Antithrombin 3 ( ATIII ) , thrombin antithrombin 3 complexes ( TAT ) , heparin cofactor 2 ( HCII ) , protein C ( PC ) , protein S ( PS ) , tissue plasminogen activator ( t PA ) , D dimer , and plasminogen activator inhibitors ( PAI 1 and PAI 2 ) levels in uncomplicated pregnancies and in pregnancies complicated by intrauterine growth retardation ( IUGR ) have been determined . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Resting levels of plasma fibrinogen , tissue type plasminogen activator ( t PA ) antigen and activity , plasminogen activator inhibitor 1 ( PAI 1 ) antigen and activity , and fibrin D dimer were measured in 24 healthy premenopausal women : 11 sedentary ( aged 28+ / 1 years ; Pre S ) and 13 physically active ( aged 30+ / 1 years ; Pre PA ) and in 27 healthy postmenopausal women : 14 sedentary ( aged 61+ / 1 years ; Post S ) and 13 physically active ( aged 58+ / 1 years ; Post PA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Using site directed mutagenesis , changes of Tyr 221 in plasminogen activator inhibitor 1 ( PAI 1 ) have provided mutants with normal activity , but with increased stability . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The effects on fibrinolysis are dominated by ( highly ) increased levels of plasminogen activator inhibitor type 1 ( PAI 1 ) , leading to inadequate fibrinolysis . ^^^ Although levels of plasminogen activator antigen are increased , its activity is almost completely inhibited by PAI 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The formation of a ternary uPA / suPAR / VN complex on the cell surface and the free extracellular matrix could be inhibited by a monoclonal antibody against VN , as well as by plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Recent studies demonstrated that u PA , plasminogen activator inhibitor type 1 ( PAI 1 ) , and tissue type plasminogen activator ( t PA ) are prognostic factors in breast cancer . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This points to plasminogen activator inhibitor 1 ( PAI 1 ) as one of the specific binding sites . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Hypofibrinolysis caused by increased plasminogen activator inhibitor 1 ( PAI 1 ) has been implicated in the vasculopathy of type 2 diabetes , typified by increased insulin , glucose , and triglycerides . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have tested the effects of Lp ( a ) lipoprotein or the apolipoprotein of Lp ( a ) lipoprotein ( apo ( a ) ) on cultured human umbilical vein endothelial cells ( HUVECs ) with respect to : ( 1 ) the level of endothelin 1 ( ET 1 ) mRNA ; ( 2 ) release of ET 1 into the culture medium ; ( 3 ) plasminogen activator inhibitor 1 ( PAI 1 ) secretion into the culture medium and ; ( 4 ) total gene expression in HUVECs , examined by a polymerase chain reaction ( PCR ) based technique , differential display reverse transcription PCR ( DD RT PCR ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have investigated the expression and cellular localization of urokinase type plasminogen activator ( uPA ) , tissue type plasminogen activator ( tPA ) , urokinase type plasminogen activator receptor ( uPAR ) , and plasminogen activator inhibitor 1 ( PAI 1 ) as well as plasminogen activation in rat liver regeneration by recruitment of progenitor ( oval ) cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Enhanced fibrinolysis observed was countered by elevated plasminogen activator inhibitor 1 ( PAI 1 ) levels , a trend similar to that observed in the amniotic fluid during labour . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) was proposed to be a link between the renin angiotensin system and thrombotic risk . ^^^ Baseline levels of PAI 1 antigen and activity and tissue plasminogen activator ( t PA ) antigen were determined in fasting morning plasma samples . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We present a systematic analysis of the sensitivity and specificity of immunohistochemical stainings for components of the plasminogen activation system , i . e . , uPA , tPA , PAI 1 , PAI 2 , and uPAR , on routinely processed ( formalin fixed , paraffin embedded ) tissues . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The relative distribution of urokinase type plasminogen activator ( u PA ) , tissue type plasminogen activator ( t PA ) , plasminogen activator inhibitor 1 ( PAI 1 ) and plasminogen activator inhibitor 2 ( PAI 2 ) was studied in cultured human gingival fibroblasts , healthy gingival tissues and inflamed gingival tissues by immunohistochemistry . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This study was designed to characterize the direct effects of hyperglycemia on plasminogen activator inhibitor 1 ( PAI 1 ) expression in cultured vascular smooth muscle cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : We studied the coagulation cascade , natural clotting inhibitors , fibrinolytic proteins and resistance to activated protein C in 20 patients with advanced gastrointestinal cancer and 84 volunteers by measuring PT , APTT , fibrinogen , AT 3 , PC , PS , APC resistance , fibrinolytic system ( PLG , ANPL , PAI 1 , and t PA ) and activation peptides ( D Dimers , prothrombin 0 fragment 1 + 2 / F1 + 2 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Non lipid mechanisms of estrogen action include decreasing insulin resistance , serum fibrinogen , factor 7 and plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) , which is present in plasma , platelets , and vascular endothelium , may be an important determinant of the resistance of arterial thrombi to lysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Most of the variance in DCLT ( 68 % in men , 63 % in women ) was explained by tissue type plasminogen activator ( t PA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) activities . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is unique among the serpins because of its conformational flexibility . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In this study , the effects of ANP on the enhanced expression of tissue factor ( TF ) and plasminogen activator inhibitor 1 ( PAI 1 ) by angiotensin 2 ( Ang 2 ) in cultured rat aortic endothelial cells ( RAECs ) were examined . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Thirteen amino acid substitutions have been introduced within the stretch Phe 113 to Asp 138 in the plasminogen activator inhibitor 1 ( PAI 1 ) molecule by site directed mutagenesis . ^^^ The PAI 1 variants have been characterized by their reactivity with tissue plasminogen activator ( tPA ) , interactions with vitronectin or heparin , and stability . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To better understand the impact of two common polymorphisms of the tissue type plasminogen activator ( t PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) genes on the in vivo regulation of fibrinolysis , we have studied this genetic variables together with other clinical and metabolic factors in a sample of the Italian population . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Oligonucleotides with a nucleotide sequence complementary to various regions of human plasminogen activator inhibitor type 1 ( PAI 1 ) mRNA have been studied as antisense inhibitors of expression of PAI 1 protein in cultured cells [ human umbilical vein endothelial cells ( HUVEC ) , human aortic smooth muscle cells , human hybrid endothelial cells ] . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Mean plasminogen activator inhibitor ( PAI 1 ) activity was higher in ApoE E 4 allele bearing individuals ( E3 / E4 + E4 / E4 , 11 . 89 ( SE 1 . 27 ) U / ml ; E3 / E3 , 9 . 19 ( SE 0 . 80 ) U / ml ; E2 / E3 , 7 . 21 ( SE 1 . 04 ) U / ml , P values of E 4 group 5 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Specifically , t PA antigen , plasminogen activator inhibitor 1 ( PAI 1 ) , and D dimer were measured preoperatively ( preop ) and on Postoperative Days ( POD ) 1 and 7 by the ELISA method . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Zymography and Northern blot analysis of purified astroglial , microglial , and mixed glial cell cultures demonstrated that astroglial cells produce tPA and a plasminogen activator inhibitor ( PAI 1 ) and are thereby responsible for the production of plasmin which may activate the inactive TGF in these cultures . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
However , the strength of triglyceride as a risk factor for CHD may depend partially on its association with other variables ( e . g . , hypertension , plasminogen activator inhibitor 1 [ PAI 1 ] , etc . ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To examine the relationship between plasma plasminogen activator inhibitor 1 ( PAI 1 ) activity and PAI 1 gene ( 4G / 5G ) polymorphism and diabetic retinopathy in Pima Indians with type 2 diabetes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Soluble thrombomodulin ( sTM ) and plasminogen activator inhibitor type 1 ( PAI 1 ) were investigated as markers of endothelial dysfunction in 35 patients after autologous or allogeneic BMT and compared with the occurrence of the typical complications sepsis , veno occlusive disease of the liver ( VOD ) , graft versus host disease ( GVHD ) , and capillary leakage syndrome ( CLS ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The 4G allele of the plasminogen activator inhibitor ( PAI 1 ) gene is associated with increased PAI 1 levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Increased plasma levels of insulin and the fibrinolytic inhibitor , plasminogen activator inhibitor type 1 ( PAI 1 ) , are two new cardiovascular risk factors . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) plasma levels have been consistently related to a polymorphism ( 4G / 5G ) of the PAI 1 gene . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor ( PAI 1 ) and fibrinolysis activity and ( ELT ) were determined . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Urokinase type plasminogen activator ( uPA ) and one of its inhibitors , the PAI 1 , are involved in the proteolytic cascade of matrix degradation during in vivo morphogenesis or metastasis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Regulation of tissue type plasminogen activator ( tPA ) and type 1 plasminogen activator inhibitor ( PAI 1 ) gene expression in rat hepatocytes in primary culture . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
MEASUREMENT AND RESULT : t PA , PAI 1 , t PA PAI 1 complexes , plasminogen , fibrinogen and plasmin alpha 2 antiplasmin complexes were measured serially by ELISA and free u PA by SDS PAGE with zymography . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Agonist activity of antiestrogen receptor complexes to regulate urokinase plasminogen activator ( uPA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) endogenous gene expression in breast cancer cells . ^^^ We now describe the regulation of urokinase plasminogen activator ( uPA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) endogenous gene expression by estradiol ( E 2 ) and different antiestrogens in BC 2 cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : In children , haemolytic uraemic syndrome ( HUS ) is associated with high plasma plasminogen activator inhibitor type 1 ( PAI 1 ) , which may contribute to the persistence of renal glomerular and arteriolar thrombi . ^^^ METHODS : We measured tissue type plasminogen activator ( t PA ) and PAI 1 activities in the plasma of 18 HIV infected patients with biopsy proven HUS ( HIV+ / HUS+ ) and 48 HIV infected patients without HUS ( HIV+ / HUS ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Levels of Factor 7 : C ( FVII : C ) , fibrinogen , plasminogen activator inhibitor 1 ( PAI 1 ) and von Willebrand factor ( vWF ) were estimated in 296 subjects from one centre . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A common 4G allele in the promoter of the plasminogen activator inhibitor 1 ( PAI 1 ) gene as a risk factor for pulmonary embolism and arterial thrombosis in hereditary protein S deficiency . ^^^ Reduced fibrinolytic capacity due to increased plasminogen activator inhibitor 1 ( PAI 1 ) activity in plasma is a common finding in patients with coronary heart disease or venous thromboembolism , although its clinical significance is debated . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Two enzyme linked immunosorbent assays ( ELISAs ) for the quantitation of rat plasminogen activator inhibitor 1 ( PAI 1 ) antigen and activity , respectively , in biological fluids were developed using monoclonal antibodies raised against recombinant rat PAI 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We subjected the complex between the serine proteinase urokinase type plasminogen activator ( uPA ) and the serpin plasminogen activator inhibitor 1 ( PAI 1 ) to proteolytic digestion under nondenaturing conditions . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma fibrinogen ( FGN ) , tissue type plasminogen activator ( t PA ) , plasminogen activator inhibitor 1 ( PAI 1 ) , lipoprotein ( a ) ( Lp ( a ) ) , and net fibrinolytic activity of plasma were assayed 6 24 months after transplant as indicators of the fibrinolytic system and then correlated with the IVUS measurements . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
But it was established that this secretory protein , complexing urokinase in cultured media , is not identical to the plasminogen activator inhibitor type 1 ( PAI 1 ) . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The current study was performed to determine whether peripheral arterial disease ( PAD ) and its progression are also associated with impaired fibrinolysis , by measurement of tissue plasminogen activator ( tPA , the activator of fibrinolysis ) and its inhibitor plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Previous studies by our group and other groups indicated that the generation of plasminogen activator inhibitor 1 ( PAI 1 ) , the major physiological inhibitor for plasminogen activators , from cultured vascular smooth muscle cells ( SMC ) is elicited by thrombin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : Plasma tissue type plasminogen activator ( tPA ) , urokinase type plasminogen activator ( uPA ) , and the plasminogen activator inhibitors ( PAI 1 and PAI 2 ) were evaluated and compared with plasma 17 beta estradiol levels , ranging from 20 pg / mL to > 5 , 000 pg / mL during the course of treatment . ^^^ However , the major plasminogen activator inhibitor ( PAI 1 ) also decreased ; thus , the net clinical effect in terms of increased potential for thrombosis should be minimal . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We previously reported that type 1 plasminogen activator inhibitor ( PAI 1 ) levels are significantly increased in plasma and placenta from pregnant women with preeclampsia compared to normal pregnant women . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To evaluate the association among known angiogenic growth factors or factors related to the plasminogen activation system and clinicopathological factors in patients with colorectal cancer , we examined the expression of vascular endothelial growth factor ( VEGF ) , basic fibroblast growth factor ( bFGF ) , transforming growth factor alpha ( TGF alpha ) , urokinase type plasminogen activator ( u PA ) , u PA receptor ( u PA R ) and plasminogen activator inhibitor 1 ( PAI 1 ) in clinical specimens of colorectal cancers by Northern blot analysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We measured the abundance and activity of urokinase plasminogen activator ( uPA ) , and the levels of PA inhibitor ( PAI 1 ) and insulin like growth factor 1 ( IGF 1 ) in conditioned media from both explants and osteoblast like cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Therefore , we investigated the relationship between fasting plasma insulin , total and regional adiposity , fasting plasma glucose and lipids , plasma plasminogen activator inhibitor 1 ( PAI 1 ) , fibrinogen , and coagulation factor 7 in a sample of 100 healthy free living octogenarians nonagenarians ( 52 men and 48 women ) who were disability free according to the Katz index . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fasting plasma insulin , plasminogen activator inhibitor 1 ( PAI 1 ) activity , plasma triglyceride concentrations , and systolic ( SBP ) and diastolic ( DBP ) blood pressure were not significantly different between the three ACE genotypes among nondiabetic and diabetic subjects . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
After intervention , significant between group differences in favor of doxazosin were found : lower triglycerides ( p = 0 . 008 ) and higher HDL cholesterol ( p = 0 . 036 ) ; furthermore , improvement of fibrinolysis : lower plasminogen activator inhibitor 1 ( PAI 1 ) activity ( p = 0 . 012 ) , higher tissue plasminogen activator ( tPA ) activity after venous occlusion ( VO ) ; and higher levels of serum D dimer , both unstimulated ( p = 0 . 0016 ) and after VO ( p = 0 . 0032 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Because recent data suggest that the balance between plasminogen activators ( PAs ) and type 1 plasminogen activator inhibitor ( PAI 1 ) plays a role in regulating cell migration within the extracellular matrix , we investigated the expression of these molecules by immunohistochemical and in situ hybridization analysis of pulmonary artery specimens from patients suffering fatal pulmonary embolism . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Raloxifene did not significantly change high density lipoprotein cholesterol ( HDL C ) , triglycerides , or plasminogen activator inhibitor 1 ( PAI 1 ) ; whereas HRT increased HDL C by 11 % and triglycerides by 20 % , and decreased PAI 1 by 29 % ( for all , P < . 001 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Impaired fibrinolysis due to excessive production of the plasminogen activator inhibitor 1 ( PAI 1 ) are further risk factors which participate in the process of atherogenesis from the beginning of formation of the atheromatous plaque to the thrombotic occlusion of the vascular lumen . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor ( PAI 1 ) and diabetes mellitus . 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Type 1 plasminogen activator inhibitor ( PAI 1 ) is a major physiologic inhibitor of plasminogen activation . ^^^ Incubation of HTC rat hepatoma cells with the cyclic nucleotide analogue , 8 bromo cAMP , causes a dramatic increase in tissue type plasminogen activator activity secondary to a 90 % decrease in PAI 1 mRNA . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Human plasminogen activator inhibitor 1 ( PAI 1 ) is a gene that is potently induced by TGF beta . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We studied the effects of PRAP 1 , a PAI 1 inhibiting polyclonal antibody , on tissue type plasminogen activator ( t PA ) induced lysis of arterial like thrombi prepared in vitro from rat and human blood in a Chandler loop device . ^^^ The plasminogen activator inhibitor ( PAI 1 ) activity was 7 . 5 + / 2 . 8 ( rat ) and 3 . 4 + / 1 . 3 ( human ) times higher in the thrombus head compared with the tail . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Comparing combined low and usual alcohol periods , an increase in mean weekly alcohol intake from 92 to 410 ml ( mean daily intake from 13 to 58 ml ) was associated with a decrease in plasma fibrinogen ( by 11 % , P < 0 . 001 ) and platelet count ( 3 % , P < 0 . 05 ) , but increases in factor 7 ( 7 % , P = 0 . 001 ) , tissue plasminogen activator ( tPA ; 16 % , P = 0 . 01 ) and plasminogen activator inhibitor 1 ( PAI 1 ; 21 % , P < 0 . 001 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We also measured urokinase type PA ( uPA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) , which may not be endothelium derived but share major clearance pathways with tPA . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Concurrently , the expression of pro alpha 1 ( 1 ) collagen , fibronectin , and plasminogen activator inhibitor 1 ( PAI 1 ) was also quantified by hybridization of total mRNA from TGF beta 1 ( + / + ) and TGF beta 1 ( / ) embryonic fibroblasts . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The degradation was inhibited by the addition of plasminogen activator inhibitor type 1 ( PAI 1 ) or aprotinin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Among anticoagulant and fibrinolytic factors , an elevated plasma plasminogen activator inhibitor 1 ( PAI 1 ) concentration has been identified as a risk factor for the development of myocardial infarction . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Smokers had : lower mean serum HDL cholesterol ( 0 . 76 versus 0 . 81 mmol / l ) and higher mean serum fasting triglyceride ( 1 . 92 versus 1 . 71 mmol / l ) , which will increase atherosclerosis ; higher mean plasma fibrinogen ( 2 . 75 versus 2 . 67 g / l ) and plasminogen activator inhibitor 1 [ PAI 1 ] ( 24 . 9 versus 22 . 2 ng / ml ) , which will increase thrombosis ; and lower mean plasma vitamin C ( 4 . 4 versus 6 . 4 mg / l ) and serum selenium ( 118 versus 123 microg / l ) , which may increase atherosclerosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fibrinogen ( 13 % ) and plasminogen activator inhibitor 1 ( PAI 1 ) concentrations ( 26 % ) decreased , but there were no changes in thrombotic markers including thrombin antithrombin 3 complex , prothrombin fragment 1 . 2 , D dimer , antithrombin activity , protein C and S and von Willebrand factor antigen . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We examined the relation of general and visceral adiposity to plasma hemostatic factors [ fibrinogen , D dimer , and plasminogen activator inhibitor 1 ( PAI 1 ) ] in obese boys and girls 7 11 y of age ( n = 41 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fibrinolytic measures included tissue plasminogen activator ( TPA ) antigen and plasminogen activator inhibitor ( PAI 1 ) activity , and as coagulation factors we examined factors VIIc , factor VIIIc , and fibrinogen . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS AND RESULTS : Confluent CMECs were exposed to IL 1 in serum free medium for 24 hours , and cell conditioned medium was assayed for plasminogen activator inhibitor type 1 ( PAI 1 ) , the primary physiological inhibitor of plasminogen activators , and for type 1 collagen with Western blotting . ^^^ IL 1 ( 2 ng / mL ) specifically increased the accumulation of PAI 1 ( 4 . 4 + / 0 . 6 fold ; mean + / SD ; n = 9 ) without affecting tissue plasminogen activator ( t PA ) or urokinase plasminogen activator ( u PA ) levels , which remained unchanged . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Our results may be relevant in explaining the phenomenology of such proteins as human plasminogen activator inhibitor 1 ( PAI 1 ) , photosystem 2 , and prions . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue type plasminogen activator ( tPA ) and its inhibitor ( PAI 1 ) in patients treated with continuous ambulatory peritoneal dialysis . ^^^ AIM : To establish whether the values of two key enzymes of fibrinolysis , tissue type plasminogen activator ( tPA ) and its inhibitor ( PAI 1 ) , differ between patients treated with continuous ambulatory peritoneal dialysis ( CAPD ) and healthy volunteers and whether plasma and dialysate tPA and PAI 1 values vary during one exchange of dialysis solution . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) activity and antigen were higher than at B 1 on SU therapy ( 23 . 7 5 19 . 9 AU 10 mL ( 1 ) ( P = . 02 ) and 47 . 6 5 32 . 2 ng 10 mL ( 1 ) ( P = . 006 ) , respectively ) , but not on 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A paradoxical coexisting hypofibrinolysis was found as suggested by a low global fibrinolytic activity in the euglobulin plasma fraction fibrin plate assay ( FA , p < 0 . 01 ) and high levels of tissue plasminogen activator inhibitor type 1 ( PAI 1 , p < 0 . 01 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
MAIN OUTCOME MEASURES : Plasma lipids , fibrinogen , factor 7 coagulant activity ( FVIIc ) , and plasminogen activator inhibitor type 1 ( PAI 1 ) antigen . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Bovine mammary epithelial ( BME UV 1 , clone E T and BME UV , clone E T 2 ) and myoepithelial ( BMM UV , clone m T 2 ) cell lines were used to study the modulation of cell associated activity of urokinase type plasminogen activator ( u PA ) , as well as mRNA transcripts of u PA , its receptor ( u PAR ) , and inhibitors ( PAI 1 and PAI 2 ) during the cell cycle . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : Inhibition of fibrinolysis attributable to elevated concentrations of plasminogen activator inhibitor type 1 ( PAI 1 ) in blood is associated with insulin resistance , hyperinsulinemia , and type 2 diabetes mellitus . ^^^ METHODS AND RESULTS : Samples acquired by directional coronary atherectomy from 25 patients with type 2 diabetes and 18 patients without diabetes were characterized qualitatively histologically for cellularity and by immunohistochemistry visually and qualitatively and by quantitative image analysis for assessment of urokinase type plasminogen activator ( u PA ) and PAI 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : Plasminogen activator inhibitor type 1 ( PAI 1 ) is an important endogenous regulator of the fibrinolytic system . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We previously reported that plasminogen activator inhibitor 1 ( PAI 1 ) is dramatically up regulated in the plasma and adipose tissues of genetically obese mice . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
MEASUREMENTS AND MAIN RESULTS : Blood samples were analyzed for tissue plasminogen activator ( TPA ) activity , TPA antigen , plasminogen activator inhibitor 1 ( PAI 1 ) activity , prothrombin complex F1 . 2 , and antithrombin 3 ( AT 3 ) at the following times : before cardiopulmonary bypass ( CPB ) , during CPB ( 30 and 60 minutes ) , post CPB , and day 1 postsurgery . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Aspirin therapy will reduce platelet activation both by its negative effect on platelet aggregation ( SPA ) and by inhibition of granule release which liberates such mediators as platelet factor 4 ( PF 4 ) and plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma concentrations of plasminogen activator inhibitor ( PAI 1 ) , prothrombin fragment F1+2 , fibrinogen , and von Willebrand Factor ( vWF ) activity were measured . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : Plasminogen activator inhibitor 1 ( PAI 1 ) , the main inhibitor of plasminogen activators in plasma and in peritoneum , impairs plasmin formation that is essential for the repair processes of the mesothelium damaged by peritoneal dialysis fluids and peritonitis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Synthesis of plasminogen activator inhibitor type 1 ( PAI 1 ) , a major physiological modulator of plasmin generation , is regulated by growth factors and changes in cell shape . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To determine whether hyaluronan alters the expression of the fibrinolytic system protein , plasminogen activator inhibitor type 1 ( PAI 1 ) , in human vascular SMCs , thereby potentially accelerating vascular disease in patients with type 2 diabetes . ^^^ METHODS : Urokinase type and tissue type plasminogen activators ( uPA and tPA ) and PAI 1 were assayed in vascular SMC conditioned media and in cell lysates , using enzyme linked immunosorbent assay and western blotting . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor ( PAI 1 ) and markers of endothelial dysfunction in patients with diabetes mellitus ] . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : Transforming growth factor Beta ( TGF Beta ) arrests many cell types in the G 1 phase of the cell and upregulates plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Most importantly , however , MC lack plasminogen activator inhibitors ( PAI 1 , PAI 2 , PAI 3 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The close proximity of binding sites for alpha ( 5 ) integrins and plasminogen activator inhibitor 1 ( PAI 1 ) on vitronectin may have consequences for cell adhesion and migration , or for the localized inhibition of plasminogen activators . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To investigate a potential physiological role of the plasminogen / plasmin system in activation of the matrix metalloproteinase ( MMP ) system , the distribution of latent and active MMP 2 ( gelatinase A ) or MMP 9 ( gelatinase B ) was monitored in aorta extracts and in serum free conditioned cell culture medium obtained from wild type ( WT ) mice and from mice with deficiency of tissue type plasminogen activator ( t PA ( / ) ) , urokinase type plasminogen activator ( u PA ( / ) ) , plasminogen activator inhibitor 1 ( PAI 1 ( / ) ) or plasminogen ( Plg ( / ) ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The aim of the study was to investigate whether infection of endothelial cells with human cytomegalovirus ( HCMV ) perturbs expression and production of plasminogen activator inhibitor type 1 ( PAI 1 ) . mRNA expression of PAI 1 was investigated by isolating total RNA from HCMV infected and control cells , followed by Northern blotting and probing with 32P labelled PAI 1 probe . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
K and TNK tPA are more fibrin specific than rt PA , and are also resistant to inactivation by plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To understand the hormonal regulation of the components of the plasminogen plasmin system in human breast cancer , we examined the oestradiol ( E 2 ) regulation of plasminogen activators ( PAs ) , namely urokinase type plasminogen activator ( uPA ) and tissue type plasminogen activator ( tPA ) , plasminogen activator inhibitor type 1 ( PAI 1 ) and uPA receptor ( uPAR ) , in our model system . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Cell growth is arrested and plasminogen activator inhibitor 1 ( PAI 1 ) is upregulated . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In this study we analyzed the expression and distribution of the urokinase plasminogen activator ( uPA ) , its membrane receptor ( urokinase plasminogen activator receptor [ uPAR ] ) , and its inhibitor ( plasminogen activator inhibitor 1 [ PAI 1 ] ) in acute necrotizing pancreatitis in human beings . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the present study , we analyzed the expression of urokinase plasminogen activator ( uPA ) , urokinase plasminogen activator receptor ( uPAR ) , and plasminogen activator inhibitor type 1 ( PAI 1 ) in samples of chronically rejected human kidneys . ^^^ CONCLUSION : The demonstrated up regulation of uPA / uPAR / PAI 1 in chronic renal rejection is consistent with the plasminogen / plasmin system contributing to tissue remodeling in this disorder . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Similar binding data and number of free binding sites , about 200 fmol / mg protein , were found for UPA in complex with its inhibitor plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The plasminogen activators tPA and uPA , and their inhibitors , PAI 1 and PAI 2 , have been associated with epithelial homeostasis and wound healing . ^^^ Collectively , these results show that keratinocyte plasminogen activator activity is suppressed by hydrocortisone as a function of increased PAI 1 combined with an attenuation of PA induction by agents that increase intracellular cAMP . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : The vascular endothelium , through the production of t PA and plasminogen activator inhibitor ( PAI 1 ) , is an important regulator of fibrinolysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The cultured mesothelial cells produced tissue type plasminogen activator ( t PA ) , urokinase plasminogen activator ( uPA ) , and plasminogen activator inhibitor type 1 and type 2 ( PAI 1 and PAI 2 ) during unstimulated conditions . ^^^ Treatment with the proinflammatory mediators LPS and TNF alpha resulted in an overall decreased fibrinolytic capacity with a decrease in the release of t PA and an increase in plasminogen activator inhibitors PAI 1 and PAI 2 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Previous studies have demonstrated that low density lipoproteins ( LDLs ) stimulate the production of plasminogen activator inhibitor 1 ( PAI 1 ) and reduce the generation of tissue plasminogen activator ( tPA ) in vascular endothelial cells ( ECs ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Leukaemic and normal bone marrow samples were compared in terms of their content of the fibrinolytic agents , tissue plasminogen activator ( t PA ) and urokinase type plasminogen activator ( u PA ) and their inhibitors . plasminogen activator inhibitors 1 and 2 ( PAI 1 and PAI 2 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Samples were taken before , at 3 and 9 months after the beginning of the program to measure : tissue type plasminogen activator ( t PA ) antigen and plasminogen activator inhibitor ( PAI 1 ) activity and antigen . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To determine the level of expression and the significance of urokinase type plasminogen activator ( uPA ) and its plasminogen activator inhibitor type 1 ( PAI 1 ) in adenocarcinoma of the esophagus , we studied 54 tumor cases and a control group of normal gastric mucosa cases with ELISA using detergent extracted samples . uPA and PAI 1 were significantly elevated as compared to control tissue by factors of 16 and 14 , respectively . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
All patients received placebo and each drug for 8 weeks in randomised order in a double blind , cross over study designed to evaluate any different effects of the drugs on serum lipoproteins , cholesteryl ester transfer protein ( CETP ) , cholesteryl ester transfer activity ( CETA ) , plasma fibrinogen , plasminogen activator inhibitor 1 ( PAI 1 ) or paraoxonase . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The molecular integrity of the TGF beta , receptors in all cell lines , except ME 180 and C 33A , could be confirmed by examining the distinct transcriptional induction of plasminogen activator inhibitor 1 ( PAI 1 ) , p 21 ( WAF1 / CIP1 ) and , in some cases , the accompanying downregulation of c myc in response to TGF beta . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor type 1 ( PAI 1 ) , the primary inhibitor of urinary type plasminogen activator , is thought to play an important role in the control of stroma invasion by both endothelial and tumor cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Elevated plasminogen activator inhibitor 1 ( PAI 1 ) levels have been described in some populations to associate with hyperinsulinaemia in the metabolic syndrome which predisposes to coronary heart disease ( CHD ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) activity was measured in plasma and in the supernatants of the washed and gel filtered platelets after activation by thrombin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Employing a fibrin clot lysis assay , we reassessed the significance of the neutralization of plasminogen activator inhibitor type 1 ( PAI 1 ) activity by thrombin and factor Xa in fibrinolysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The present study was designed to investigate the effect of prolactin ( PRL ) on plasminogen activator inhibitor 1 ( PAI 1 ) and tissue type plasminogen activator ( tPA ) gene expression in eCG primed granulosa cells in vitro . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Production of urokinase type plasminogen activator ( u PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) in human brain tumours . ^^^ We investigated the role of plasminogen activators ( PAs ) and their inhibitor ( plasminogen activator inhibitor 1 , PAI 1 ) in human brain tumours . ^^^ The amounts of urokinase type plasminogen activator ( u PA ) , tissue type plasminogen activator ( t PA ) , and plasminogen activator inhibitor 1 ( PAI 1 ) , and the activity of u PA and t PA were determined by enzyme linked immunosorbent assay ( ELISA ) , and u PA and PAI 1 were immunolocalized using monoclonal antibodies in human brain tumours and normal brain tissues . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
When mesangial cells are exposed to the TxA 2 agonist U 46619 , a substantial increase in production of plasminogen activator inhibitor 1 ( PAI 1 ) protein is observed that is significantly greater than that induced by 10 % serum alone . ^^^ Thus TxA 2 stimulates the production of PAI 1 and plasminogen activators by mesangial cells through a receptor dependent mechanism . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The plasma urokinase type plasminogen activator ( uPA ) , plasminogen activator inhibitor 1 ( PAI 1 ) , and urokinase type plasminogen activator receptor ( uPAR ) levels were measured in healthy volunteers and breast cancer patients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
D dimers , tissue plasminogen activator ( t PA ) , plasminogen activator inhibitor ( PAI 1 ) , tumour necrosis factor alpha ( TNF alpha ) and full blood counts were measured . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue extraction procedures for investigation of urokinase plasminogen activator ( uPA ) and its inhibitors PAI 1 and PAI 2 in human breast carcinomas . ^^^ Urokinase type plasminogen activator ( uPA ) and its inhibitors , plasminogen activator inhibitor type 1 ( PAI 1 ) and type 2 ( PAI 2 ) , are supposed to be involved in the expression of the invasive and metastatic phenotype of cancer cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We analysed the expression of several down stream molecules known to be involved in TGF beta signalling ( Smads ) and TGF beta mediated cell cycle regulation ( cyclins D ) during the differentiation of control and wtT beta RII expressing ES cells and showed that upregulation of these molecules correlated with ( 1 ) an increase in plasminogen activator inhibitor 1 ( PAI 1 ) synthesis and ( 2 ) growth inhibition , following addition of TGF beta 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To investigate this question , we overexpressed plasminogen activator inhibitor 1 ( PAI 1 ) , an inhibitor of t PA and u PA , in a rat model of aortic aneurysm . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Abnormal expression of fibrinolytic genes [ e . g . , tissue type and urokinase type plasminogen activators ( t PA and u PA ) and their specific inhibitor ( PAI 1 ) ] and of the procoagulant molecule tissue factor ( TF ) , has been reported in various types of renal diseases . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
By using suspended human umbilical vein endothelial cells ( HUVEC ) , which are free from the formation of extracellular matrix ( ECM ) where type 1 plasminogen activator inhibitor ( PAI 1 ) preferably accumulates and interacts with t PA with high affinity we demonstrated a relatively low affinity binding site for t PA on the cells and identified a novel t PAR . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue type plasminogen activator ( t PA ) and plasminogen activator inhibitor ( PAI 1 ) were studied in 18 smokers and 18 closely matched non smokers , all of whom had Type 1 diabetes mellitus ( DM ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In particular , we describe tissue factor , tissue factor pathway inhibitor , prothrombin fragment 1 . 2 , thrombin antithrombin complex , fibrinopeptide A , tissue plasminogen activator ( t PA ) , plasminogen activator inhibitor 1 ( PAI 1 ) , t PA PAI complex , Bbeta 15 42 related peptides , fibrinogen degradation products , fibrin degradation products , D dimer , platelet factor 4 , beta thromboglobulin , 5 hydroxytryptamine , thromboxane B 2 , prostacyclin , endothelin , angiotensin converting enzyme , soluble thrombomodulin , C 1 esterase inhibitor , anaphylotoxins C3a , C4a , and C5a , bradykinin , tumor necrosis factor , leukotriene C 4 , platelet activating factor , anti phospholipid antibody , and von Willebrand factor . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
TGF beta 1 was added at concentrations of 0 , 1 , 5 , and 10 ng / mL with or without plasminogen activator inhibitor type 1 ( PAI 1 ) at concentrations of 0 , 5 , 10 , 50 , and 100 micrograms / mL . ^^^ RESULTS : TGF beta 1 and PAI 1 inhibited the conversion of plasminogen into angiostatin in a time and dose dependent manner . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The significant correlations became more attenuated ( and nonsignificant ) after adjustment for cardiovascular risk factors , especially plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
These include reduced levels of high density lipoprotein ( HDL ) cholesterol , hypertriglyceridemia , increased small dense LDL particles , hypertension , visceral obesity , and increased levels of plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Selection of peptides that bind to plasminogen activator inhibitor 1 ( PAI 1 ) using random peptide phage display libraries . ^^^ Panning of the hexa peptide library on immobilized plasminogen activator inhibitor 1 ( PAI 1 ) specifically selected a minor fraction of concatemers , indicating that binding to PAI 1 requires an extended amino acid sequence . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
RESULTS : Substance P caused dose dependent increases in blood flow ( P < 0 . 001 ) and plasma t PA antigen ( P = 0 . 04 ) and activity ( P < 0 . 001 ) concentrations confined to the infused forearm , but had no effect on plasminogen activator inhibitor type 1 ( PAI 1 ) or von Willebrand factor concentrations . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue plasminogen activator ( T PA ) and plasminogen activator inhibitor ( PAI 1 ) levels in the conditioned medium of cultured porcine brain microvascular endothelial cells . ^^^ Vascular endothelial cells are known to produce tissue plasminogen activator ( t PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Urokinase type plasminogen activator and plasminogen activator inhibitors ( PAI 1 and PAI 2 ) in extracts of invasive cervical carcinoma and precursor lesions . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is produced by the endothelium and determines the rate and extent of fibrinolysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The increased IGFBP 3 proteolysis most probably resulted from amplified expression of tissue type plasminogen activator ( t PA ) and depression of its inhibitor ( PAI 1 ) observed in IGFBP 2 expressing xenografts . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Before the patients underwent PTCA , blood was obtained by venipuncture for measurement of Lp ( a ) , total cholesterol , thrombin antithrombin ( TAT ) complex , alpha 2 antiplasmin plasmin ( APP ) complex , and plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The following haemostatic parameters were determined ; thrombelastography , fibrinogen , antithrombin 3 ( ATIII ) , thrombin antithrombin ( TAT ) complex , beta thromboglobulin ( beta TG ) , plasminogen activators ( t PA , u PA ) , plasminogen activator inhibitors ( PAI 1 , PAI 2 ) , and plasminogen . ^^^ No significant differences were seen for TAT complex , PAI 1 , plasminogen and D dimer levels although their mean levels were higher than observed in non pregnant subject except for PAI 2 , the level was significantly reduced when compared with normal pregnancy . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is a unique member of the serpin superfamily because of its conformational and functional flexibility . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) concentrations were measured similarly but did not differ among the three groups . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Sertoli cells secrete plasminogen activators ( PAs ) on both sides of the blood testis barrier , i . e . , in the basal and apical compartments of the seminiferous tubules , whereas peritubular cells secrete plasminogen activator inhibitor 1 ( PAI 1 ) , a fast acting and specific PA inhibitor . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Subcultured SF were cultivated for 2 , 4 , 6 , 8 , 10 and 13 days and the medium assayed for the presence of both plasminogen activators ( PAs ) and plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Blood was collected before and after each exercise test and was analyzed for the fibrinolytic variables , tissue plasminogen activator ( t PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) activity , and lactate . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor ( PAI 1 ) antigen levels in primary TTP and secondary TTP post bone marrow transplantation . ^^^ Our objectives were to measure and compare plasminogen activator inhibitor levels ( PAI 1 ) in primary adult thrombotic thrombocytopenic purpura ( TTP ) and in secondary TTP associated with bone marrow transplantation ( BMT ) TTP . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
However , protein levels of plasminogen activator inhibitor 1 ( PAI 1 ) , a specific inhibitor of urokinase , were increased by 16K PRL independent of the action of bFGF . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Coordinated induction of plasminogen activator inhibitor 1 ( PAI 1 ) and inhibition of plasminogen activator gene expression by hypoxia promotes pulmonary vascular fibrin deposition . ^^^ Plasma levels of plasminogen activator inhibitor 1 ( PAI 1 ) antigen , detected by ELISA , increased in a time dependent fashion after hypoxic exposure ( increased as early as 4 h , P < 0 . 05 vs . normoxic controls ) , and were accompanied by an increase in plasma PAI 1 activity by 4 h ( P < 0 . 05 vs . normoxic controls ) . ^^^ Northern analysis of hypoxic murine lung demonstrated an increase in PAI 1 mRNA compared with normoxic controls ; in contrast , transcripts for both tissue type plasminogen activator ( tPA ) and urokinase type plasminogen activator ( uPA ) decreased under hypoxic conditions . ^^^ These studies identify enhanced expression of PAI 1 as an important mechanism suppressing fibrinolysis under conditions of low oxygen tension , a response which may be further amplified by decreased expression of plasminogen activators . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Single chain urokinase plasminogen activator ( scuPA ) , the unique form secreted by cells , expresses little intrinsic plasminogen activator activity . scuPA can be activated by proteolytic cleavage to form a two chain enzyme ( tcuPA ) , which is susceptible to inhibition by plasminogen activator inhibitor type 1 ( PAI 1 ) . scuPA is also activated when it binds to its cellular receptor ( uPAR ) , in which case the protein remains as a single chain molecule with less susceptibility to PAIs . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
At the same stages , a prominent expression of plasminogen activator inhibitor type 1 ( PAI 1 ) by spongiotrophoblasts and giant trophoblasts , as well as of LDL receptor related protein ( LRP ) by spongiotrophoblasts and decidual cells could be detected , suggesting a role in regulating extracellular proteolysis in the area of fetomaternal interface . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : We examined the expression of components of the matrix metalloproteinase ( MMP ) system and plasminogen activator inhibitor type 1 ( PAI 1 ) in kidneys from rats injected daily s . c . during three weeks with CsA ( 10 , 15 or 20 mg CsA / kg body wt ) or vehicle solution . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Considerable evidence suggests that high plasma concentrations of plasminogen activator inhibitor type 1 ( PAI 1 ) and fibrinogen increase the risk of cardiovascular disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Pretreatment plasminogen activator inhibitor 1 ( PAI 1 ) levels and the outcome of thrombolysis with streptokinase in patients with acute myocardial infarction . ^^^ BACKGROUND : The risk for reinfarctions and delays in reperfusion after streptokinase therapy may be caused by the antifibrinolytic effect of platelet derived type 1 plasminogen activator inhibitor ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Augmentation of arterial endothelial cell expression of the plasminogen activator inhibitor type 1 ( PAI 1 ) gene by proinsulin and insulin in vivo . ^^^ We have shown previously that insulin and proinsulin typically elevated in blood in patients with type 2 diabetes increase plasma activity of plasminogen activator inhibitor type 1 ( PAI 1 ) in vivo . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
PURPOSE : To compare the prognostic impact of tumor angiogenesis factors ( vascular endothelial growth factor [ VEGF ] , angiogenin , and basic fibroblast growth factor [ bFGF ] ) , tumor proteolysis factors ( urokinase type plasminogen activator [ uPA ] and plasminogen activator inhibitor 1 [ PAI 1 ] ) , and conventional tumor markers ( stage , grade , and steroid receptors ) in early breast cancer . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Thrombin can regulate the fibrinolytic system by increasing the endothelial production of both tissue plasminogen activator ( t PA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
There was no significant relationship between either of the nm 23 isoforms and cathepsin D ( Cat D ) , urokinase plasminogen activator ( uPA ) , its inhibitor ( PAI 1 ) , steroid hormone receptors or ploidy status . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Human endometrial stromal cell cultures , stimulated for two days with recombinant transforming growth factor beta 1 ( TGFbeta 1 ; 10 ng / ml ) , contained conditioned medium concentrations of urokinase plasminogen activator ( uPA ) , plasminogen activator inhibitor 1 ( PAI 1 ) , and uPA : PAI 1 complex . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The mRNAs of ECM degrading components urokinase type plasminogen activator ( uPA ) , plasminogen activator inhibitor 1 ( PAI 1 ) , matrix metalloproteinase 1 ( MMP 1 ) , and tissue inhibitor of metalloproteinases 1 ( TIMP 1 ) , as well as TGFbeta 1 , bFGF , and FGFR , were detected during IVM in a factor specific pattern : all transcript levels found at COC 0 generally increased after 3 h of maturation and either remained high or decreased thereafter . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is a serine protease inhibitor of the serpin superfamily which rapidly inactivates tissue plasminogen activator ( tPA ) , but reacts with thrombin at a much slower rate . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The serpin plasminogen activator inhibitor 1 ( PAI 1 ) can occur , in vitro , in both an inhibitory and a non inhibitory but cleavable substrate form . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Preoperative lens epithelium expressed epidermal growth factor ( EGF ) , EGF receptor ( R ) , fibroblast growth factor ( FGF ) , FGF R , interleukin ( IL ) 1 RII , tumor necrosis factor alpha ( TNF alpha ) , plasminogen activator inhibitor type 1 ( PAI 1 ) , keratin and laminine . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Endothelial cells express fibrinolytic proteins including : urokinase ( u PA ) and tissue type ( t PA ) plasminogen activators , type 1 ( PAI 1 ) and 2 ( PAI 2 ) plasminogen activator inhibitors , and u PA receptor ( u PAR ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
High levels of plasminogen activator inhibitor 1 ( PAI 1 ) in tissue extracts have been associated with poor prognosis in many epithelial cancers . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Elevated plasminogen activator inhibitor 1 ( PAI 1 ) and fibrinogen concentrations are risk factors for coronary heart disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In addition , plasminogen activator inhibitor type 1 ( PAI 1 ) activity was found to be significantly and positively associated with tPA antigen concentration ( P < 0 . 001 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
TGF beta signals through type 1 and 2 receptor serine / threonine kinases and induces transcription of many genes including plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : Immunohistochemistry and Western blot analysis were performed using an antibody that detects free tPA antigen and tPA complexed to its rapid inhibitor , plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The transcriptional localizations of urokinase type plasminogen activator ( uPA ) , its receptor ( uPAR ) and its inhibitors ( PAI 1 and PAI 2 ) , which are possibly involved in cancer metastasis , have not been determined in human lung cancer . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The tissue concentrations of urokinase type plasminogen activator ( u PA ) , urokinase type plasminogen activator receptor ( u PAR ) , plasminogen activator inhibitor type 1 ( PAI 1 ) and tissue type plasminogen activator ( t PA ) were investigated by an ELISA technique in normal and malignant samples of the prostate from 24 patients undergoing radical prostatectomy for organ confined prostate cancer . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To investigate whether nonenzymatic glycated end products ( AGEs ) have effects on the expression and bioactivity of plasminogen activator inhibitor 1 ( PAI 1 ) , one of the seripin proteinases , which lead to extracellular matrix ( ECM ) degradation in cultured human mesangial cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Elevated plasminogen activator inhibitor 1 ( PAI 1 ) is a risk factor for thrombosis , and inhibitors of the interaction between PAI 1 and tissue plasminogen activator ( t PA ) have antithrombotic and prothrombolytic activity in animals . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To identify the binding sites for RAP , lactoferrin , and plasminogen activator inhibitor 1 ( PAI 1 ) , a bacterial expression system has been developed to produce soluble LRP fragments spanning residues 783 1399 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Antithrombin 3 , thrombin antithrombin 3 complexes , heparin cofactor 2 , protein C , protein S , tissue plasminogen activator , ( t PA ) D dimer and plasminogen activator inhibitor ( PAI 1 and PAI 2 ) activities in normal and gestational diabetes pregnancies were determined . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Both the urokinase type plasminogen activator receptor ( uPAR ) and the plasminogen activator inhibitor 1 ( PAI 1 ) are thought to be important factors in this system . ^^^ Urokinase type plasminogen activator receptor mRNA , PAI 1 mRNA , uPAR and PAI 1 protein were diffusely distributed in the cytoplasm of the cancer cells and concentrated at invasive foci . ^^^ Plasminogen activator inhibitor 1 protein expression correlated with lymphatic , venous invasion , lymph node metastasis and depth of invasion ( P < 0 . 01 ) ; PAI 1 mRNA expression was linked to lymphatic , venous invasion ( P < 0 . 01 ) , lymph node metastasis and depth of invasion ( P < 0 . 05 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Lipid profiles , fibrinogen , Factor 7 , and plasminogen activator inhibitor 1 ( PAI 1 ) were measured by routine laboratory methods . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The effects of transforming growth factor beta 1 ( TGF beta 1 ) and basic fibroblast growth factor ( bFGF ) were examined on the accumulation of plasminogen activator inhibitor 1 ( PAI 1 ) mRNA in astrocytes in vitro . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fasting samples were analysed for serum lipids ( total , HDL and LDL cholesterol and triglyceride ) and plasma fibrinogen , factor 7 coagulant ( FVII : C ) activity , tissue plasminogen activator ( t PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) activities . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
One determinant of this system is the balance between plasminogen activators ( tissue type plasminogen activator [ t PA ] ) and inhibitors ( plasminogen activator inhibitor 1 [ PAI 1 ] ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To test critically the role and timing of these steps in the reaction of the plasminogen activator inhibitor PAI 1 , we blocked the vacant position 4 in beta sheet A of this serpin with an octapeptide . ^^^ The peptide blocked PAI 1 was a substrate for both tissue type plasminogen activator ( tPA ) and trypsin and was hydrolyzed at the scissile bond . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
RESULTS : Plasminogen activator inhibitor 1 ( PAI 1 ) activity and antigen decreased significantly but similarly by 30 and 40 % , respectively , in both the placebo and the metformin groups . ^^^ In contrast to the results for PAI 1 , there was a significantly greater decrease in tissue type plasminogen activator ( tPA ) antigen in the metformin than in the placebo group ( mean+ / SD : 1 . 1+ / 3 . 1 vs . 0 . 2+ / 3 . 2 ng / ml , P < 0 . 02 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
RESULT ( S ) : The concentrations of urokinase plasminogen activator ( u PA ) and PAI 1 were higher in endometrium from women with endometriosis than in endometrium from controls and even higher in endometriotic tissue than in endometrium from both groups . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To evaluate the effect of the uremic environment on the fibrinolytic activity of endothelial cells , we studied plasminogen activator ( t PA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) production by human umbilical vein endothelial cells ( HUVEC ) in culture , exposed either to uremic or normal sera , before and after cytokine stimulation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Biologic variables analyzed included apolipoprotein B ( apo B ) , lipoprotein ( a ) , C reactive protein ( CRP ) , fibrinogen , factor 7 , tissue plasminogen activator ( TPA ) and inhibitor ( PAI 1 ) , thrombin antithrombin ( TAT ) , fragment 1+2 ( F1+2 ) , von Willebrand factor ( vWF ) , activated protein C resistance , homocyst ( e ) ine , anticardiolipin antibodies , blood group , and the angiotensin converting enzyme insertion / deletion ( I / D ) and angiotensin 2 receptor gene polymorphisms . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In vivo studies have demonstrated a strong positive correlation between plasma very low density lipoprotein ( VLDL ) triglyceride and plasma plasminogen activator inhibitor 1 ( PAI 1 ) activity levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Increased plasminogen activator inhibitor type 1 ( PAI 1 ) levels , leading to impaired fibrinolysis , are associated with increased visceral fat in middle aged and obese subjects . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Increased expression of plasminogen activator inhibitor 1 ( PAI 1 ) has been reported in atherosclerotic and balloon injured vessels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) has been shown to be an independent risk factor for coronary artery disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have reported previously that both urokinase type plasminogen activator ( uPA ) and its type 1 inhibitor ( PAI 1 ) are statistically significant prognostic variables in patients with high risk breast cancer ( Grondahl Hansen et al . , Cancer Res . , 53 : 2513 2521 , 1993 ) , and we recently described that the uPA receptor ( uPAR ) is a prognostic marker in postmenopausal , node positive breast cancer patients ( Grondahl Hansen et al . , Clin . ^^^ These data , together with previously published data on the prognostic significance of components of the urokinase plasminogen activation system in breast cancer cytosols , strongly indicate that PAI 1 is a statistically significant and independent prognostic marker in both low and high risk breast cancer patients . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have recently described the urokinase type plasminogen activator ( uPA ) and its type 1 inhibitor ( PAI 1 ) as strong prognostic variables in breast cancer ( J . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
There was a weak positive correlation ( r = 0 . 22 ) between p 53 protein and plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor ( PAI 1 ) and diabetes mellitus . 2 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The low density lipoprotein receptor related protein / alpha2 macroglobulin receptor ( LRP / alpha2MR ) mediates the internalization of numerous ligands , including prourokinase ( pro UK ) and complexes between two chain urokinase ( tc u PA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have investigated the biochemical mechanism of tumor necrosis factor ( TNF ) alpha induced release of plasminogen activator inhibitor 1 ( PAI 1 ) from human umbilical vein endothelial cells ( HUVEC ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In contrast , plasminogen activator inhibitor 1 ( PAI 1 ) immunoreactive material was localized exclusively in serous cells of seromucinous glands . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : In patients with established ischemic heart disease , prospective cohort studies have indicated that plasminogen activator inhibitor ( PAI 1 ) , the inhibitor of the fibrinolytic system , may predict cardiovascular events . ^^^ METHODS AND RESULTS : The aim of the present study was to test whether plasma levels of PAI 1 , tissue type plasminogen activator ( tPA ) , von Willebrand factor ( vWF ) , and thrombomodulin ( TM ) could predict the occurrence of a first acute myocardial infarction ( AMI ) in a population with high prevalence of coronary heart disease by use of a prospective nested case control design . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS AND RESULTS : To investigate the relation between donor specific fibrinolytic protein genotypes and Tx CAD , we identified donor plasminogen activator inhibitor 1 ( PAI 1 ) HindIII and tissue plasminogen activator ( TPA ) EcoRI restriction fragment length polymorphisms based genotypes by Southern blot analysis in 48 recipients of cardiac allografts and correlated these genotypes with the development of CAD . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Levels of plasminogen activator inhibitor 1 ( PAI 1 ) activity and tissue PA ( t PA ) antigen were measured in Type 2 diabetes subjects with ( n=40 ) and without ( r=80 ) acute stroke compared to non diabetic subjects with ( n=80 ) and without ( n=80 ) acute ischaemic stroke . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Samples were drawn from the donors to determine the normal range of histamine , plasminogen activator inhibitor 1 ( PAI 1 ) , myeloperoxidase ( MPO ) and interleukin ( IL ) 6 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Hypoxia in tumors and expression of high levels of tumor associated plasminogen activator inhibitor 1 ( PAI 1 ) indicate a poor prognosis for some cancer patients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Also , plasma levels of plasminogen activator inhibitor 1 and 2 ( PAI 1 , PAI 2 ) increased during pregnancy . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
External quality assessment of trans European multicentre antigen determinations ( enzyme linked immunosorbent assay ) of urokinase type plasminogen activator ( uPA ) and its type 1 inhibitor ( PAI 1 ) in human breast cancer tissue extracts . ^^^ High levels of urokinase type plasminogen activator ( uPA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) in breast cancer tissue extracts have been associated with rapid disease progression . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : Plasma levels of modified antithrombin 3 ( ATM ) , tissue plasminogen activator ( TPA ) , its inhibitor ( PAI 1 ) , TPA PAI 1 complexes and plasmin antiplasmin complexes ( PAP ) , d dimer , and fibrinogen were measured in plasma from 36 patients with chronic atrial fibrillation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The low density lipoprotein receptor related protein ( LRP ) , a multi functional endocytic receptor , mediates the cellular internalization of tissue type ( t PA ) and urokinase type ( u PA ) plasminogen activator and their complexes with plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Levels of mRNA for plasminogen activator inhibitor 1 ( PAI 1 ) , tissue inhibitor of metalloprotease 1 ( TIMP 1 ) , alpha 1 ( 4 ) collagen , and fibronectin EIIIA ( FN EIIIA ) mRNAs were significantly enhanced in kidneys within 12 h to 3 days after injury and remained elevated at 7 28 days postischemia relative to levels in kidneys of sham operated controls . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : An insertion or deletion ( I / D ) polymorphism in the angiotensin converting enzyme ( ACE ) gene and a 4 / 5 guanine tract polymorphism ( 4G / 5G ) in the promoter region of the plasminogen activator inhibitor 1 ( PAI 1 ) gene are associated with the plasma activities of these substances and with coronary heart disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The placenta is a source of both plasminogen activator inhibitor type 2 ( PAI 2 ) and type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Urokinase type plasminogen activator ( uPA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) in tissue and serum of head and neck squamous cell carcinoma patients . ^^^ The aim of this study was to determine urokinase type plasminogen activator ( uPA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) concentrations in tumour and adjacent normal tissue samples from 58 patients , and in serum samples from 40 of 58 patients with squamous cell carcinoma of the head and neck obtained at diagnosis and after completion of therapy . uPA and PAI 1 serum concentrations were also measured in 28 healthy volunteers who served as controls . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We used a blood brain barrier ( BBB ) model to analyze regulation of brain capillary endothelial tPA and its inhibitor , plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The effect of number of days in culture and plasminogen activator inhibitor 1 ( PAI 1 ) 4G / 5G genotype on PAI 1 antigen release by cultured human umbilical vein endothelial cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To test this hypothesis , we examined the effect of salt depletion on tissue type plasminogen activator ( tPA ) antigen and plasminogen activator inhibitor 1 ( PAI 1 ) activity and antigen in normotensive subjects in the presence and absence of quinapril ( 40 mg BID ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The following biochemical parameters were determined in all men : cholesterol Ch ; triglycerides TG ; phospholipids PL ; apolipoproteins : Apo A , Apo A 1 , Apo B ; lipoproteins : VLDL , LDL , HDL and their lipids and proteins components ; lipoprotein ( a ) Lp ( a ) ; fibrinogen Fb ; euglobulin lysis time ELT ; inhibitor tissue plasminogen activator PAI 1 ; antithrombin 3 AT 3 ; spontaneous platelet aggregation SPA , platelet factor 4 PF 4 and glucose . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In both groups the activated partial thromboplastin time ( APTT ) , prothrombin ratio ( INR ) , fibrinogen , euglobulin lysis time ( ELT ) , platelet number and platelet adhesion and aggregation , tissue plasminogen activator antigen ( t PA Ag ) and activity of plasminogen activator inhibitor ( PAI 1 ) were tested and compared . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
RESULTS : The fibrinolytic capacity showed marked circadian variation at the end of the placebo phase ( p = 0 . 002 ) , plasminogen activator inhibitor 1 ( PAI 1 ) activity peaking at 06 . 00 AM when tissue plasminogen activator ( tPA ) activity was at its nadir . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The present review discusses recent research showing adipose tissue to be highly metabolically active , producing and releasing many different bioactive compounds besides free fatty acids ( FFA ) such as tumor necrosis factor alpha ( TNF alpha ) , leptin , acetylation stimulating protein ( ASP ) , plasminogen activator inhibitor 1 ( PAI 1 ) , cholesterol ester transfer protein ( CETP ) , prostaglandins and oestrogens . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Triglyceride enriched lipoproteins are accompanied by elevations in factor 7 clotting activity , plasminogen activator inhibitor ( PAI 1 ) and viscosity of blood and plasma . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Several recent studies have reported contradicting results concerning the relevance of the plasminogen activator inhibitor 1 ( PAI 1 ) 4G / 5G polymorphism for myocardial infarction . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Epidemiological studies have demonstrated that levels of plasma fibrinogen , von Willebrand factor ( vWf ) , plasminogen activator inhibitor 1 ( PAI 1 ) and tissue type plasminogen activator ( tPA ) are associated with the incidence of vascular disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To investigate the underlying molecular mechanisms , we examined the effects of advanced glycation endproducts ( AGE ) , non enzymatically glycated protein derivatives , on the production of prostacyclin ( PGI 2 ) , an anti thrombogenic prostanoid , and of plasminogen activator inhibitor 1 ( PAI 1 ) , a fast acting serine protease inhibitor of fibrinolysis , in human microvascular endothelial cells ( EC ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS AND RESULTS : To evaluate hemostatic variables as potential risk determinants platelet aggregation ( PA , representing platelet activity ) , thrombin / antithrombin complexes ( TAT , representing thrombin generation ) , and plasminogen activator inhibitor type 1 ( PAI 1 , representing endogenous fibrinolysis ) were determined in 31 patients with AMI at 0 , 1 , 2 . and 12 h after the start of thrombolysis as well as at hospital discharge . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In addition , fibrates have been found to alter the plasma concentrations of fibrinogen , plasminogen activator inhibitor 1 ( PAI 1 ) and apolipoprotein A 1 ( apo A 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We investigated the effect of CsA therapy on the regulation of fibrinolysis in kidney graft recipients by measuring plasma concentration and activity of plasminogen activators ( tPA , uPA ) and their inhibitors ( PAI 1 , 2 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Incubation of HTC rat hepatoma cells with the cyclic nucleotide analogue 8 bromo cAMP results in a 3 fold increase in the rate of degradation of type 1 plasminogen activator inhibitor ( PAI 1 ) mRNA . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To evaluate von Willebrand factor ( vWF ) , tissue plasminogen activator antigen ( t PA ) and its activity before and after venous occlusion , plasminogen activator inhibitor ( PAI 1 ) , dehydroepian drosterone sulphate ( DHEAS ) , and established clinical risk factors as long term predictors for reinfarction and mortality . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
F 3 fraction enhanced mRNA expression of urokinase type plasminogen activator ( u PA ) , matrix metalloproteinase 2 ( MMP 2 ) , and membrane type MMP ( MT MMP ) in CPAE cells whereas the expression of plasminogen activator inhibitor 1 ( PAI 1 ) mRNA was not changed . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Proinflammatory cytokines such as tumor necrosis factor alpha ( TNFalpha ) play an important role in the regulation of EC and also regulate the production of plasminogen activator inhibitor type 1 ( PAI 1 ) , which is an EC producing factor with the inhibitory activity of fibrinolysis , and the expression of intercellular adhesion molecule 1 ( ICAM 1 ) , which is an adhesion molecule that plays an important role in inflammation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Accumulated data indicate that endocytosis of the glycosylphosphatidyl inositol anchored protein urokinase plasminogen activator receptor ( uPAR ) depends on binding of the ligand uPA : plasminogen activator inhibitor 1 ( PAI 1 ) and subsequent interaction with internalization receptors of the low density lipoprotein receptor family , which are internalized through clathrin coated pits . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is a specific inhibitor of plasminogen activators and may be the principal regulator of plasminogen activation in vivo . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have characterized the regulation of plasminogen activator inhibitor 1 ( PAI 1 ) gene expression by phorbol 12 myristate 13 acetate ( PMA ) , serum , and interleukin 1alpha ( IL 1alpha ) in the human hepatoma cell line HepG 2 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Among these 56 differentially expressed genes are 42 known genes , including the hallmark endothelial cell activation markers interleukin 8 ( IL 8 ) , monocyte chemoattractant protein 1 ( MCP 1 ) , vascular cell adhesion molecule 1 ( VCAM 1 ) , plasminogen activator inhibitor 1 ( PAI 1 ) , Gro alpha , Gro beta and E selectin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Blood samples were processed for the determination of tissue plasminogen activator ( t PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Finally , crossing PAI 2 / with PAI 1 / mice to generate animals deficient in both plasminogen activator inhibitors failed to uncover an overlap in function between these two related proteins . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Changes in tissue plasminogen activator ( t PA ) and plasminogen activator inhibitor ( PAI 1 ) , another two endothelium derived proteins and modulators of blood fibrinolytic activity , have not been reported in hyperthyroidism . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : Human mesothelial cells ( HMCs ) have an important role in maintaining an adequately functioning fibrinolytic system in the peritoneal cavity by secreting the fibrinolytic enzymes tissue type and urokinase type plasminogen activator ( t PA and u PA ) , as well as a specific PA inhibitor , PA inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The following hemostatic parameters were studied : plasma fibrinolytic activity ( PFA ) , euglobulin fibrinolytic activity ( EFA ) , tissue type plasminogen activator ( t PA ) , fast acting plasminogen activator inhibitor 1 ( PAI 1 ) , and D dimer ( D D ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The level of plasminogen activator inhibitor 1 ( PAI 1 ) was also evaluated by Northern blotting and protein radiolabeling . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The aim of this study was to evaluate the effect of a new antihypertensive agent , moxonidine ( M ) , on microalbuminuria ( urine albumin excretion , UAE ) , plasma thrombomodulin ( TM ) , and tissue plasminogen activator inhibitor ( PAI 1 ) in patients with mild to moderate EH associated with increased UAE . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Measures of hypofibrinolysis ( reduced ability to lyse thrombi ) included lipoprotein Lp ( a ) , plasminogen activator inhibitor activity , and polymerase chain reaction analysis of the hypofibrinolytic 4G / 5G polymorphism of the PAI 1 gene . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Here we show that enhanced cell attachment contributes to the suppression via increased secretion of fibronectin ( FN ) and also of plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We investigated whether plasma levels of the plasminogen activator inhibitor type 1 antigen ( PAI 1 : Ag ) are genetically determined in monozygotic ( MZ ) and dizygotic ( DZ ) twins . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : Tissue plasminogen activator ( tPA ) , its inhibitor ( PAI 1 ) , plasmin antiplasmin complexes ( PAP ) and D dimer were measured in 13 patients with rheumatic atrial fibrillation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
MC were examined by Giemsa staining and by immunohistochemistry using antibodies against tryptase , chymase , tissue type plasminogen activator ( tPA ) , urokinase ( uPA ) , urokinase receptor ( uPAR ) , and plasminogen activator inhibitors ( PAI 1 , PAI 2 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Two timed haemostasis measurements included the determination of coagulation factors , protein C ( PC ) , protein S ( PS ) , C4b binding protein ( C4bBP ) , antithrombin ( AT ) , and plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen Activator Inhibitor ( PAI 1 ) activity was higher on the palmitic acid compared with the oleic acid diet ( difference between diets of 2 . 3 U / ml ; P = 0 . 0098 ; 95 % CI , 0 . 4 to 4 . 3 U / ml ) and the lauric acid diet ( difference between diets of 2 . 2 U / ml ; P = 0 . 0123 ; 95 % CI , 0 . 2 to 4 . 1 U / ml ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Increased concentrations of plasminogen activator inhibitor type 1 ( PAI 1 ) and of D dimer have jointly been found in subjects with cardiovascular disease . ^^^ To understand this apparent paradox of increased inhibition of fibrinolysis ( high PAI 1 ) combined with increased fibrinolytic activity ( high D dimer ) , we examined the relation between D dimer , PAI 1 and the activator of fibrinolysis , tissue type plasminogen activator ( t PA ) in subjects with varying severity of peripheral atherosclerosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Transforming growth factor beta ( TGF beta ) exerts its effects on cell proliferation , differentiation and migration in part through its modulation of extracellular matrix components , such as fibronectin and plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Regulation of tissue type plasminogen activator and its inhibitor ( PAI 1 ) by lipopolysaccharide induced phagocytosis in a Sertoli cell line . ^^^ The mechanisms controlling the expression of PA and of its major physiological inhibitor , plasminogen activator inhibitor type 1 ( PAI 1 ) , in the seminiferous epithelium are still unknown . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The very low density lipoprotein receptor ( VLDLr ) binds diverse ligands , including urokinase type plasminogen activator ( uPA ) and uPA plasminogen activator inhibitor 1 ( PAI 1 ) complex . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is a major regulator of fibrinolysis ; elevation of PAI 1 is associated with an increased risk of thrombotic disorders . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Vitronectin ( VN ) binds to plasminogen activator inhibitor 1 ( PAI 1 ) and integrins and may play an important role in the vascular response to injury by regulating fibrinolysis and cell migration . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The activities of plasmin activator inhibitor 1 ( PAI 1 ) and tissue type plasminogen activator ( t PA ) , as well as t PA antigen levels , were determined in plasma before , during and 60 min after the infusion of angiotensin 2 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NaPPS and CaPPS stimulated the release of tissue plasminogen activator ( t PA ) , superoxide dismutase , and lipases from vascular endothelium while concomitantly decreasing plasma levels of the endogenous plasminogen activator inhibitor PAI 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fibrinogen , factor 7 mass concentration ( FVII : Ag ) , activated factor 7 ( FVIIa ) , von Willebrand factor ( vWF ) , and plasminogen activator inhibitor 1 ( PAI 1 ) were measured . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We studied 3 plasma antigenic markers of fibrinolysis , viz , plasminogen activator inhibitor 1 ( PAI 1 ) , fibrin fragment D dimer , and plasmin antiplasmin complex ( PAP ) for the prediction of arterial thrombosis in healthy elderly persons over age 65 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor type 1 ( PAI 1 ) is a major physiological inhibitor of fibrinolysis , with its plasma levels correlating with the risk for myocardial infarction and venous thrombosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A strong and independent relationship between plasminogen activator inhibitor 1 ( PAI 1 ) antigen and insulin and its precursors ( proinsulin , 32 33 split proinsulin ) was found consistently across varying states of glucose tolerance ( PAI 1 versus fasting insulin [ proinsulin ] , r=0 . 38 [ r=0 . 34 ] in normal glucose tolerance ; r=0 . 42 [ r=0 . 43 ] in impaired glucose tolerance ; and r=0 . 38 [ r=0 . 26 ] in type 2 diabetes ; all P < 0 . 001 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
High levels of plasminogen activator inhibitor 1 ( PAI 1 ) and preponderance of small dense low density lipoproteins ( LDL ) have both been associated with atherosclerotic disease and with the insulin resistance syndrome ( IRS ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The increased ovarian proteolytic activity associated with ovulation is controlled by locally produced specific inhibitors , plasminogen activator inhibitor 1 ( PAI 1 ) and tissue inhibitor of metalloproteases 1 ( TIMP 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma levels of the thrombin antithrombin complex ( TAT ) , tissue factor pathway inhibitor free antigen ( TFPI Fag ) , protein S free antigen , plasminogen activator inhibitor type 1 ( PAI 1 ) activity and serum levels of triglycerides were significantly increased , whereas plasma levels of antithrombin ( AT ) , fibrinogen , C4b binding protein ( C4b BP ) , PAI 2 antigen and serum HDL cholesterol levels were decreased in the presence of preeclampsia . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The recombinant protein was titrated with the Erythrina caraffa trypsin inhibitor ( ETI ) and characterized in its interaction with plasminogen and the natural inhibitor plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^ The P225Y mutation did not result in cation binding , but caused a significant loss of specificity ( up to 100 fold ) toward chromogenic substrates and plasminogen and considerably reduced the inhibition by PAI 1 and ETI . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The very low density lipoprotein receptor ( VLDLR ) binds , among other ligands , the Mr 40 , 000 receptor associated protein ( RAP ) and a variety of serine proteinase serpin complexes , including complexes of the proteinase urokinase type plasminogen activator ( uPA ) with the serpins plasminogen activator inhibitor 1 ( PAI 1 ) and protease nexin 1 ( PN 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Treatment of HUVEC with 15d PGJ 2 also reduced mRNA levels of vascular endothelial cell growth factor receptors 1 ( Flt 1 ) and 2 ( Flk / KDR ) and urokinase plasminogen activator and increased plasminogen activator inhibitor 1 ( PAI 1 ) mRNA . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) was expressed in both the granulation tissue and the granular cell layer of the matrix , but not in the basal epithelial cells ; PAI 2 showed a pericellular expression pattern in the subbasal and granular cell layers . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In a collective of 112 node negative breast cancer patients , we compared the prognostic impact of HER 2 / neu gene amplification ( AMP ) determined by fluorescence in situ hybridization ( FISH ) and HER 2 / neu protein overexpression ( EXP ) measured by immunohistochemistry ( IHC ) with traditional prognostic factors ( tumor size , grade , steroid hormone receptor status , menopausal status ) and tumor invasion markers uPA ( urokinase type plasminogen activator ) and its inhibitor PAI 1 determined by enzyme immunoassay ( ELISA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) in its active conformation : crystallization and preliminary 10 ray diffraction data . ^^^ Because of its intrinsic lability , wild type plasminogen activator inhibitor 1 ( PAI 1 ) can not be crystallized in its active conformation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In addition , the effects of ACE 1 on plasma levels of plasminogen activator inhibitor ( PAI 1 ) and of tissue plasminogen activator ( TPA ) were studied . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Transforming growth factor beta ( TGFbeta ) activates transcription of the plasminogen activator inhibitor type 1 ( PAI 1 ) gene through a major TGFbeta responsive region ( 740 and 647 ) in the PAI 1 promoter . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Urokinase and plasminogen activator inhibitor ( PAI 1 ) status in primary ovarian carcinomas and ovarian metastases compared to benign ovarian tumors as a function of histopathological parameters . ^^^ Ninety eight patients with histologically confirmed ovarian tumors ( 77 primary ovarian carcinomas of stages T 1 to T 3 according to the postoperative histopathological classification pTNM classification , 14 ovarian metastases of various origins and seven benign ovarian tumors ) were investigated with regard to the concentration of urokinase type plasminogen activator ( uPA ) and plasminogen activator inhibitor ( PAI 1 ) in membrane extracts of tumors . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Prognostic impact of urokinase type plasminogen activator ( uPA ) and its inhibitor ( PAI 1 ) in cytosols and pellet extracts derived from 892 breast cancer patients . ^^^ To evaluate the clinical relevance of urokinase type plasminogen activator ( uPA ) and its type 1 inhibitor ( PAI 1 ) measured by a recently developed enzyme linked immunosorbent assay ( ELISA ) , we analysed both components in samples derived from 892 patients with primary breast cancer ( median follow up 99 months ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Induced transcription of the plasminogen activator inhibitor type 1 ( PAI 1 ) gene in serum free cultures of normal rat kidney ( NRK 52E ) cells following disruption of actin microfilament structures with cytochalasin D ( CD ) provides a simple model to probe mechanisms underlying shape related expression control . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The following parameters were determined : glycaemia , HbA1c , blood level fibrinogen , euglobulin clot lysis time , plasminogen activator inhibitor ( PAI 1 ) activity , microalbuminuria , triglyceride , total , HDL and LDL cholesterol concentration . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma levels of fibrinogen , coagulation factor VIIc , tPA and plasminogen activator inhibitor ( PAI 1 ) antigen were measured before and after intervention . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have studied effects of the solvent composition on the activity and the conformation of human plasminogen activator inhibitor 1 ( PAI 1 ) from HT 1080 fibrosarcoma cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
HL 60 cells treated by PMA develop the monocyte adherent phenotype and synthesize plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A low estrogen status in postmenopausal women is associated with elevated plasma levels of plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is likely to play a role in vascular disease , primarily in subjects with android obesity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Type 1 plasminogen activator inhibitor ( PAI 1 ) is the primary inhibitor of tissue and urokinase type plasminogen activators . ^^^ The somatomedin B ( SMB ) domain of VN contains both the high affinity PAI 1 binding site and the specific site for urokinase plasminogen activator receptor ( uPAR ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
C 1 inhibitor , prekallikrein and PAI 1 normalized after repeated infusions of lys plasminogen . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The active process of pericellular proteolysis is central in tumor invasion , and in particular the essential role of the urokinase type plasminogen activator ( uPA ) is well established . uPA mediated plasminogen activation facilitates cell migration and invasion through extracellular matrices by dissolving connective tissue components . uPA , its receptor ( uPAR ) and plasminogen activator inhibitor 1 ( PAI 1 ) are enriched in several types of tumors . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Activity of both plasminogen tissue activator ( t PA ) and plasminogen activator inhibitor ( PAI 1 ) were also determined . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the present study the ability of plasminogen activator inhibitor type 1 ( PAI 1 ) to interfere with platelet and megakaryoblastic cell adhesion was investigated . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The relevance of plasminogen activator inhibitor 1 ( PAI 1 ) as a marker for the diagnosis of hepatic veno occlusive disease in patients after bone marrow transplantation . ^^^ Recently , plasminogen activator inhibitor 1 ( PAI 1 ) , the main inhibitor of the fibrinolytic system , has been found to be significantly elevated in VOD patients probably reflecting hypofibrinolysis in these patients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We evaluated the prognostic impact of the protease urokinase plasminogen activator ( uPA ) and its inhibitor PAI 1 on overall survival in patients with advanced ovarian cancer stage FIGO IIIc in order to select patients at risk . uPA and PAI 1 antigen were determined by ELISA in primary tumour tissue extracts of 86 ovarian cancer patients FIGO stage IIIc enrolled in a prospective study . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Histamine , interleukin 6 ( IL 6 ) , plasminogen activator inhibitor 1 ( PAI 1 ) , eosinophil cationic protein ( ECP ) and myeloperoxidase ( MPO ) were analysed in plasma or serum collected from all patients 30 min before skin incision , at skin incision and 5 , 10 and 30 min and thereafter every 30 min after skin incision until the grafts were secured by wrapping . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Elevated plasminogen activator inhibitor 1 ( PAI 1 ) plasma levels , responsible for reduced fibrinolysis , are associated with animal and human obesity and with increased cardiovascular disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) rapidly inactivates tissue plasminogen activator ( tPA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This study aimed to identify the intracellular signaling pathway in angiotensin 2 ( Ang 2 ) induced upregulation of plasminogen activator inhibitor type 1 ( PAI 1 ) mRNA expression in cultured rat glomerular mesangial cells , and to examine the interaction between Ang 2 and TGF beta signaling . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We show here that hK 2 rapidly forms a complex with plasminogen activator inhibitor 1 ( PAI 1 ) , the primary inhibitor of uPA in tissues . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In this study , we show that in human keratinocytes HGF / SF but not the related cytokine macrophage stimulating protein ( MSP ) significantly increases expression of VEGF and plasminogen activator inhibitor 1 ( PAI 1 ) on the level of protein and mRNA . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Zn2+ induced cell adhesion to VN was abolished by cation chelators such as 1 10 phenanthroline , as well as by plasminogen activator inhibitor 1 ( PAI 1 ) and a monoclonal antibody ( MoAb ) against uPAR . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Definite increase in tissue type plasminogen activator ( t PA ) antigen ( p = 0 . 00075 ) with a modest elevation of its inhibitor plasminogen activator inhibitor 1 ( PAI 1 ) ( p = 0 . 27 ) probably contributes to this effect . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The leukocyte derived and platelet derived bioactive substances histamine , eosinophil cationic protein ( ECP ) , eosinophil protein 10 ( EPX ) , myeloperoxidase ( MPO ) , plasminogen activator inhibitor type 1 ( PAI 1 ) , and activated complement factor C 3 ( C3a ) and various coagulation factors and split products were analyzed in patient and drainage blood samples . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The effects of plateletpheresis on plasma levels of prothrombin fragment ( F ( 1+2 ) ) , D dimer , plasmin plasmin inhibitor ( PPI ) complexes , and plasminogen activator inhibitor ( PAI 1 ) ; on the activation of neutrophils ( % L selectin+ ) ; and on the frequency of platelet neutrophil aggregates ( % CD41+ neutrophils ) were compared . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Synthesis of the major negative physiologic regulator of plasmin activation [ plasminogen activator inhibitor type 1 ( PAI 1 ) ] is elevated during progressive cellular senescence , in premature aging disorders ( e . g . , Werner ' s syndrome ) , and in conditions associated with tissue fibrosis and excessive fibrin accumulation ( e . g . , sclerosis , keloid formation ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
VLDL activation of plasminogen activator inhibitor 1 ( PAI 1 ) expression : involvement of the VLDL receptor . ^^^ The potential role of the very low density lipoprotein ( VLDL ) receptor in mediating VLDL induced plasminogen activator inhibitor 1 ( PAI 1 ) expression was studied in vitro . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The present study compares plasma urokinase plasminogen activator ( uPA ) peptide levels , plasma plasminogen inhibitor ( PAI 1 ) activity and urokinase receptors ( uPAR ) on peripheral blood monocytes of patients with stable coronary artery disease ( SCAD ) and healthy volunteers . 2 . ^^^ Urokinase plasminogen activator levels were analysed by ELISA and PAI 1 activity was determined by a plasmin generation method using the chromogenic substrate S 2390 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Forearm blood flow was assessed by venous plethysmography ; t PA and plasminogen activator inhibitor 1 ( PAI 1 ) antigen values were expressed as flow dependent ( net release , the product of venoarterial concentration gradient and forearm blood flow ) or independent ( absolute and fractional concentration gradients ) indices . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Among them , plasminogen activator 1 ( PAI 1 ) , which is a regulator of the fibrinolytic system , was overexpressed in the visceral fat in an animal model of obesity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Before and after pharmacological treatment , were evaluated the clinical symptoms ( claudicatio intermittens and rest pain ) and the following haemostatic parameters : plasma thrombomodulin ( TM ) , beta thromboglobulin ( beta TG ) , D dimer ( DD ) , tissue type plasminogen activator ( t PA ) and plasminogen activator inhibitor ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Prothrombin fragment 1+2 ( F1+2 ) , thrombin antithrombin 3 complexes ( TAT ) , tissue type plasminogen activator ( t PA ) functional and antigen , plasminogen activator inhibitor 1 ( PAI 1 ) , plasminalpha 2 antiplasmin complexes ( PAP ) , D Dimer , thrombomodulin ( TM ) and von Willebrand factor ( vWF ) were measured in patients and in 30 healthy subjects . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma levels of plasminogen , plasminogen activator inhibitor 1 ( PAI 1 ) , and alpha 2 antiplasmin were unaltered , but plasmin : alpha 2 antiplasmin ( PAP ) levels were significantly lower in TMcyt / cyt mice than in TMwt / wt mice ( 0 . 46 + / 0 . 2 and 1 . 99 + / 0 . 1 ng / mL , respectively ; P < . 001 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) promoter 4G / 5G genotype and increased PAI 1 circulating levels in postmenopausal women with coronary artery disease . ^^^ Increased circulating levels of type 1 plasminogen activator inhibitor ( PAI 1 ) have been associated with coronary artery disease ( CAD ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The purpose of this study was to evaluate the predictive value of changes in plasminogen activator inhibitor 1 ( PAI 1 ) activity and of thallium dipyridamole perfusion imaging performed 3 months after successful angioplasty . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have extended this study and evaluated whether or not this was also true for the genetic polymorphisms of tissue type plasminogen activator ( t PA ) , plasminogen activator inhibitor 1 ( PAI 1 ) , angiotensin converting enzyme ( ACE ) and angiotensinogen in a group of 133 Greenland Inuit , aged 30 34 gamma . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This study investigated whether spontaneous lipid enrichment of human macrophages affects their thrombogenic potential as measured by increased production of tissue factor ( TF ) and plasminogen activation inhibitor types 1 and 2 ( PAI 1 and PAI 2 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The role of fibrinolytic system components in thrombus formation and removal in vivo was investigated in groups of six mice deficient in urokinase type plasminogen activator ( u PA ) , tissue type plasminogen activator ( t PA ) , or plasminogen activator inhibitor 1 ( PAI 1 ) ( u PA / , t PA / or PAI 1 / , respectively ) or of their wild type controls ( u PA+ / + , t PA+ / + or PAI 1+ / + ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : The role of plasminogen system components in focal cerebral ischemic infarction ( FCI ) was studied in mice deficient in plasminogen ( Plg / ) , in tissue or urokinase plasminogen activator ( tPA / or uPA / ) , or in plasminogen activator inhibitor 1 or alpha 2 antiplasmin ( PAI 1 ( / ) or alpha 2 AP / ) . ^^^ CONCLUSIONS : Plg system components affect FCI at 2 different levels : ( 1 ) reduction of tPA activity ( tPA gene inactivation ) reduces whereas its augmentation ( PAI 1 gene inactivation ) increases infarct size , and ( 2 ) reduction of Plg activity ( Plg gene inactivation or alpha 2 AP injection ) increases whereas its augmentation ( alpha 2 AP gene inactivation or alpha 2 AP neutralization ) reduces infarct size . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Whereas VLDL has consistently been shown to induce a concentration dependent increase in the expression of plasminogen activator inhibitor 1 ( PAI 1 ) in human umbilical vein endothelial cells ( HUVECs ) and liver cells , variable effects have been reported for native and oxidatively modified LDL . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Human adipose tissue has been shown to produce plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We measured D dimer and plasminogen activator inhibitor 1 ( PAI 1 ) activity in 45 trauma patients to assess their efficacy in predicting the post traumatic hemostatic perturbations . ^^^ The PAI 1 activity and plasminogen activator activity showed a significant negative correlation on days 1 , 2 , and 3 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The effect of peroxisome proliferator activated receptor ( PPAR ) gamma activators , thiazolidinediones , on plasminogen activator type 1 ( PAI 1 ) was examined in cultured human umbilical vein endothelial cells ( HUVEC ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The anti fibrinolytic activity observed in the alveoli during hyperoxia was to a large extent prevented by KGF , most probably by suppressing the expression of plasminogen activator inhibitor 1 ( PAI 1 ) mRNA and protein . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
PURPOSE : To evaluate whether cathepsin D , urokinase type plasminogen activator ( uPA ) , its inhibitor , plasminogen activator inhibitor 1 ( PAI 1 ) , or clinical factors can predict which patients are at risk for developing distant metastases after local recurrence ( LR ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
W . of the lower limbs , ankle / brachial index , dosage of tissue plasminogen activator ( t PA ) , plasminogen activator inhibitor 1 ( PAI 1 ) , hematocrit , hematic filtration , and viscosity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The distribution of mRNAs and antigens of tissue type ( t ) and urokinase type ( u ) plasminogen activators ( PA ) plus their corresponding inhibitors , type 1 ( PAI 1 ) and type 2 ( PAI 2 ) were studied in human and rhesus monkey placentae by in situ hybridisation and immunocytochemistry . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : High levels of urokinase type plasminogen activator ( u PA ) were demonstrated in gastric carcinomas along with inhibitors of plasminogen activators ( PAI 1 and PAI 2 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
These phenotypic changes were associated with reduced expression levels of the endogenous urokinase type plasminogen activator ( uPA ) and plasminogen activator inhibitor 1 ( PAI 1 ) genes , the products of which are implicated in the control of cell adhesion and invasion . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Furthermore , plasminogen activator inhibitor type 1 ( PAI 1 ) activity , tissue plasminogen activator antigen levels , von Willebrand factor antigen levels , tissue factor pathway inhibitor ( TFPI ) activity , and endothelin 1 levels were measured . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : Tissue plasminogen activator antigen ( tPA ) and tissue plasminogen activator inhibitor 1 ( PAI 1 ) activity were measured in 20 normotensive male subjects and 46 male patients with mild essential hypertension divided into 2 groups ( 22 patients treated with 5 to 10 mg enalapril once a day and 24 treated with 5 to 10 mg nitrendipine once a day ) before and 3 months after drug administration . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In postmenopause , an increase in plasma Lp ( a ) and plasminogen activator inhibitor 1 ( PAI 1 ) levels was found . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The presence of the two plasminogen activators ( PAs ) , tissue type plasminogen activator ( tPA ) , and urokinase type plasminogen activator ( uPA ) , and their inhibitor type 1 ( PAI 1 ) in bone cells , suggests a role in one or more aspects of bone resorption such as osteoclast formation , mineral dissolution , and degradation of the organic matrix . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fibrotic disease was evaluated by urinary protein excretion , histological assessment of glomerular cell number , matrix accumulation , and production of transforming growth factor beta 1 and matrix components fibronectin and plasminogen activator inhibitor type 1 ( PAI 1 ) by isolated glomeruli in culture . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma hemostatic variables [ fibrinogen , plasminogen activator inhibitor 1 ( PAI 1 ) , and D dimer ) were measured at months 0 , 4 , and 8 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Rarer defects include heparin cofactor 2 ( HC 2 ) , plasminogen or tissue plasminogen activator deficiency ( TPA ) , elevated plasminogen activator inhibitor 1 ( PAI 1 ) and dysfibrinogenemia . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Obesity is associated with a cluster of abnormalities , including hypertension , insulin resistance , hyperinsulinemia , and elevated levels of both plasminogen activator inhibitor 1 ( PAI 1 ) and transforming growth factor beta ( TGF beta ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A cell line , TKM 33 , has been established and cloned from human umbilical vein endothelial cells , was previously reported to produce a large amount of urokinase type PA ( u PA ) and small amounts of tissue type plasminogen activator ( t PA ) and PA inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
TNF alpha has been implicated as an inducer of the synthesis of plasminogen activator inhibitor 1 ( PAI 1 ) , the primary physiological inhibitor of fibrinolysis , mediated by plasminogen activators in cultured adipocytes . ^^^ TNF alpha selectively increased the synthesis of PAI 1 without increasing activity of plasminogen activators . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The consistent positive correlation between triglyceride and plasminogen activator inhibitor 1 ( PAI 1 ) levels in plasma and the fact that very low density lipoprotein ( VLDL ) induces secretion of PAI 1 from cultured human umbilical vein endothelial cells ( HUVECs ) and human hepatoblastoma cells have raised the question of whether fibrate treatment , the main effect of which is a profound lowering of plasma concentrations of VLDL , might improve fibrinolytic function by reducing the plasma levels of PAI 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The serpin plasminogen activator inhibitor 1 ( PAI 1 ) slowly converts to an inactive latent form by inserting a major part of its reactive center loop ( RCL ) into its beta sheet A . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Studies in adults have demonstrated that the genetic mutations C677T methylenetetrahydrofolate reductase ( MTHFR ) , prothrombin 20210A , and the 4G polymorphism of the plasminogen activator inhibitor 1 ( PAI 1 ) gene are associated with elevated plasma levels of homocysteine . prothrombin and PAI 1 , respectively and with an increased risk of thrombosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Changes in urokinase plasminogen activator ( uPA ) , tissue like plasminogen activator ( tPA ) and plasminogen activator inhibitor 1 ( PAI 1 ) immunoreactivity were also assessed . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) , a rapid inhibitor of tPA , may contribute to arterial thrombolysis resistance . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : Plasminogen activator inhibitor 1 ( PAI 1 ) is a serpin that has a key role in the control of fibrinolysis through proteinase inhibition . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the retrospective study , the records of fibrinopeptide Bbeta 15 42 , plasmin antiplasmin complex , plasminogen activator inhibitor 1 antigen concentration ( PAI 1 antigen ) , and PAI 1 activity in 76 trauma patients were reviewed . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This review focuses primarily on the clinicians , point of view , suggesting that increases in plasminogen activator inhibitor type 1 ( PAI 1 ) plasma levels after balloon angioplasty or permanently elevated lipoprotein ( a ) ( Lp ( a ) ) plasma levels might be helpful in the prediction of restenosis after coronary angioplasty . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the metabolic dyshomeostasis of multiple metabolic syndrome participate in the process of atherogenesis also : isoforms of apolipoprotein E 4 , isoforms of apolipoprotein A 4 1 / 1 , hyperuricaemia , raised levels of the plasminogen activator inhibitor 1 ( PAI 1 ) , hyperfibrinogenaemia , hyperhomocysteinaemia and other metabolites ( cytokines , endothelin etc . ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
TGF beta 1 enhanced uPA production , the number of uPA cell surface binding sites , and the expression of the plasminogen activator inhibitor PAI 1 , in transformed PDV cells , but had no major effect on nontumorigenic MCA3D keratinocytes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Estrogen receptor ( ER ) , progesterone receptor ( PR ) , the estrogen inducible protein pS 2 , and plasminogen activator inhibitor 1 ( PAI 1 ) are important prognostic factors in primary breast cancer . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Cytosolic determinations of cathepsin D ( cath D ) , urokinase plasminogen activator ( uPA ) and its specific inhibitor PAI 1 have shown an association with adverse prognosis in breast cancer . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Prognostic value of tissue type plasminogen activator ( tPA ) and its complex with the type 1 inhibitor ( PAI 1 ) in breast cancer . ^^^ Determination of specific forms of components of the plasminogen activation system , i . e . tPA : PAI 1 complex and free , uncomplexed tPA and / or PAI 1 , may be considered a useful adjunct to the analyses of the separate components ( tPA and / or PAI 1 ) and provide valuable additional prognostic information with respect to survival of breast cancer patients . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Basal expression of the human plasminogen activator inhibitor 1 ( PAI 1 ) is mediated by a promoter element named B box that binds the helicase like transcription factor ( HLTF ) , homologous to SNF / SWI proteins . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We examined the effect of pH on the extraction of urokinase type plasminogen activator ( u PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) from paranasal sinus mucous membrane associated with chronic sinusitis and antrochoanal polyps . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OP 1 dose dependently inhibited activin A induced activation of p3TP Lux transcriptional reporter , containing part of the human plasminogen activator inhibitor 1 ( PAI 1 ) promoter , while activin A inhibited OP 1 mediated alkaline phosphatase induction . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor type 1 ( PAI 1 ) regulates tissue fibrinolysis and is expressed in arterial tissue ; however , its biological role remains uncertain . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The fasting insulin concentration was correlated inversely with HDL cholesterol and directly with the fasting triglyceride concentration , blood pressures , plasminogen activator inhibitor 1 ( PAI 1 ) , and tissue plasminogen activator ( tPA ) , but it was not correlated with LDL cholesterol , apolipoproteins B and A 1 , lipoprotein ( a ) , ( Lp ( a ) ) , fibrinogen , factor VIIc , or prothrombin fragment ( F ) 1 + 2 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The effects of endothelin 1 ( ET 1 ) on the production of plasminogen activator inhibitor 1 ( PAI 1 ) and tissue plasminogen activator ( t PA ) by human brain derived endothelial cells in culture were studied . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is present in the platelet alpha granule and is released on activation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
ECV 304 cells display further characteristics of endothelial cells , including the expresssion of thrombomodulin and of the vitronectin receptor CD 51 , as well as the secretion of plasminogen activator inhibitor 1 ( PAI 1 ) and endothelin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Prior studies from our laboratory have established that decidual cells of luteal phase and pregnant endometrium express two crucial modulators of hemostasis : 1 ) tissue factor ( TF ) , the primary initiator of hemostasis via factor Xa activation ; and 2 ) plasminogen activator inhibitor type 1 ( PAI 1 ) , the fast inhibitor of the primary fibrinolytic agent , tissue type plasminogen activator . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Loop insertion is an integral part of the inhibitory mechanism and also takes place at conversion of serpins to the latent state , occurring spontaneously only in plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Factors reflecting two major aspects of tumour biology , invasion ( urokinase type plasminogen activator ( uPA ) , plasminogen activator inhibiter ( PAI 1 ) , cathepsin D ) and proliferation ( S phase fraction ( SPF ) , Ki 67 , p 53 , HER 2 / neu ) , were assessed in 125 node negative breast cancer patients without adjuvant systemic therapy . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To determine the ability of radiation to modulate mesangial cell expression of various molecules involved in promoting extracellular matrix ( ECM ) accumulation [ fibronectin , plasminogen activator inhibitor 1 ( Pai 1 ) , and tissue inhibitor of metalloproteinase 2 ( Timp 2 ) ] and degradation ( Tgfb , plasminogen activators u PA or t PA , matrix metalloproteinases Mmp 2 and Mmp 9 ) , primary cultures of rat mesangial cells ( passage number 6 11 ) were placed in serum free medium 24 h prior to irradiation with single doses of 0 . 5 20 Gy ( 137 ) Cs gamma rays . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Concerning matrix turnover proteins , simvastatin markedly reduced mRNA expression of plsminogen activator inhibitor 1 ( PAI 1 ) without affecting the expression of tissue type plasminogen activator ( tPA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Samples were collected from blood units immediately after donation , and before and after leucofiltration , and analysed by ELISA and RIA methods for extracellular content of myeloperoxidase ( MPO ) , eosinophil cationic protein ( ECP ) , histamine ( HIS ) and plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Vitamin E further worsened the hypofibrinolysis documented by a decrease of tissue plasminogen activator ( P < 0 . 01 ) without changes in its inhibitor PAI 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In normal subjects and in patients with cardiovascular disease , plasma triglycerides are positively correlated with plasminogen activator inhibitor type 1 ( PAI 1 ) levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Insulin resistant states , including type 2 diabetes mellitus , are associated with increased concentrations of plasminogen activator inhibitor type 1 ( PAI 1 ) in blood and in extracted coronary atheroma , as well as with an increased incidence of acute coronary syndromes , known to be precipitated by the rupture of vulnerable atherosclerotic plaques . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Atherogenesis in the vasculature is accelerated by changes in the dynamic equilibrium between endogenous tissue plasminogen activator and plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^ Increased expression of PAI 1 , decreased expression of tissue plasminogen activator , or both can lead to decreased fibrinolytic activity and predispose to thrombosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the citrate plasma of patients studied , tissue plasminogen activator ( t PA ) , plasminogen activator inhibitor type 1 ( PAI 1 ) , plasmin alpha ( 2 ) antiplasmin ( PAP ) complexes , fibrin fibrinogen degradation products ( FDP ) and euglobulin lysis time ( ELT ) were measured . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Cell count was determined by cell counting , supernatant levels of plasminogen activator inhibitor 1 ( PAI 1 ) and endothelin 1 ( ET 1 ) by ELISA , and nitrite levels by spectroscopic colorimetric assay . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The concentrations of urokinase plasminogen activator ( uPA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) were determined by the ELISA assay . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A multicomparmental and multifactorial model of production of plasminogen activator inhibitor ( PAI 1 ) . 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A multicompartmental and multifactorial model of production of plasminogen activator inhibitor ( PAI 1 ) . 2 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In 1991 , our group was the first to report the prognostic strength of plasminogen activator inhibitor type 1 ( PAI 1 ) in primary breast cancer . ^^^ The prognostic impact of invasion markers PAI 1 and urokinase type plasminogen activator ( uPA ) on disease free survival ( DFS ) and overall survival ( OS ) in breast cancer has since been independently confirmed . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The tissue type plasminogen activator ( t PA ) is a serine protease that is involved in neuronal plasticity and cell death induced by excitotoxins and ischemia in the brain . t PA activity in the central nervous system is regulated through the activation of serine protease inhibitors ( serpins ) such as the plasminogen activator inhibitor ( PAI 1 ) , the protease nexin 1 ( PN 1 ) , and neuroserpin ( NSP ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Vascular endothelial cells play a critical role in the regulation of coagulation and fibrinolysis by controlling the expression of tissue factor ( TF ) , tissue factor pathway inhibitor ( TFPI ) , plasminogen activator inhibitor 1 ( PAI 1 ) , and tissue type plasminogen activator ( TPA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : Many studies have convincingly shown that survivors of myocardial infarction have impaired fibrinolytic activity because of increased concentrations of plasma plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Endothelial function was assessed by measuring plasma concentrations of the endothelium derived proteins endothelin ( ET ) , von Willebrand factor ( vWF ) , and plasminogen activator inhibitor type 1 ( PAI 1 ) as well as brachial artery flow mediated , endothelium dependent vasodilatation ( FMD ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : The complex between urokinase ( uPA ) and its type 1 inhibitor ( PAI 1 ) is formed exclusively from the active forms of these components ; thus , the complex concentration in a biological sample may reflect the ongoing degree of plasminogen activation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
It has recently been reported that Ang 2 stimulates the expression of plasminogen activator inhibitor 1 ( PAI 1 ) in several cell lines . ^^^ PAI 1 is a major physiological inhibitor of the plasminogen activator / plasmin system , a key regulator of fibrinolysis and extracellular matrix ( ECM ) turnover . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Urokinase type plasminogen activator ( u PA ) and tissue type plasminogen activator ( t PA ) play important roles in fibrinolysis , cell migration , tissue destruction , angiogenesis and tissue remodeling . u PA and t PA activity in tissue are tightly regulated by plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^ However , little is known of the activity of endogenous plasminogen activators ( PAs ) and PAI 1 in ischemic brain . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Clinical implications of elevated PAI 1 revisited : multiple arterial thrombosis in a patient with essential thrombocythemia and elevated plasminogen activator inhibitor 1 ( PAI 1 ) levels : a case report and review of the literature . ^^^ Plasminogen activator inhibitor ( PAI 1 ) , a member of the serine protein family , is the most active in vivo inhibitor of fibrinolysis induced by plasminogen , tissue plasminogen activator ( tPA ) , and urokinase type plasminogen activator ( uPA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The expression of tissue factor ( TF ) , tissue factor pathway inhibitor ( TFPI ) , von Willebrand factor ( vWF ) , endothelial nitric oxide ( NO ) synthase ( eNOS ) , tissue plasminogen activator ( tPA ) , its inhibitor ( PAI 1 ) , and myosin , an indicator of local shear stress , was examined in the endothelium of cerebral vessels according to vessel size and location in human autopsy brains , using immunohistochemistry . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
MAIN OUTCOME MEASURES : Body weight , oxygen consumption , plasminogen activator inhibitor type 1 ( PAI 1 ) activity , tissue plasminogen activator ( tPA ) antigen , fibrinogen and fasting plasma insulin measured at the start of the programme and at follow up after 1 year . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Total content and extracellular concentration of myeloperoxidase ( MPO ) , eosinophil cationic protein ( ECP ) , histamine and plasminogen activator inhibitor 1 ( PAI 1 ) was analysed by ELISA or RIA methods . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A reduced fibrinolytic capacity due to high levels of PAI 1 , the most important inhibitor of plasminogen activators , was suggested to play a role in the development of cardiovascular diseases and transplant coronary artery disease . ^^^ The following tests were assayed at least 1 year after transplantation : fibrinogen , factor 8 coagulant activity , von Willebrand factor antigen , euglobulin lysis time , tissue plasminogen activator antigen and activity , PAI 1 antigen and activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Angiotensin converting enzyme ( ACE ) inhibition significantly decreases plasminogen activator inhibitor 1 ( PAI 1 ) without altering tissue plasminogen activator ( tPA ) during activation of the renin angiotensin aldosterone system in humans . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We studied plasminogen activator inhibitor type 1 antigen ( PAI 1 ) , tissue type plasminogen activator antigen ( t PA ) , D dimer ( DD ) , plasmin alpha 2 antiplasmin complexes ( PAP ) , and thrombin antithrombin 3 complexes ( TAT ) in 7 children with peritonitis ( group A ) and 12 children during stable peritoneal dialysis ( group B ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : Type 1 plasminogen activator inhibitor ( PAI 1 ) is considered to be risk factor for acute myocardial infarction ( AMI ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Several studies have found an association between high plasminogen activator inhibitor 1 ( PAI 1 ) levels and myocardial infarction . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Transcription of the plasminogen activator inhibitor type 1 ( PAI 1 ) gene appears to be growth state regulated in several cell types ( e . g . , Ryan and Higgins , 1993 , J Cell Physiol 155 : 376 384 ; Mu et al . , 1998 , J Cell Physiol 174 : 90 98 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Recent studies have shown that plasminogen activator inhibitor 1 ( PAI 1 ) , a prothrombotic factor associated with atherosclerosis complications , is also produced in adipose tissue . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The following parameters were determined : plasminogen activators ( t PA , u PA ) , plasminogen activator inhibitor 1 ( PAI 1 ) , D dimer , beta thromboglobulin ( beta TG ) , thrombin antithrombin ( TAT ) complex , fibrinogen , Factor 7 , platelets , haematocrit and haemoglobin levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In 76 HD patients ( prevalent CVD , 44 of 76 patients ) , serum lipid , lipoprotein , apolipoprotein ( Apo ) , plasma fibrinogen , tissue plasminogen activator ( TPA ) , plasminogen activator inhibitor ( PAI 1 ) , and factor 7 levels were measured using standard kits . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Children with meningococcal sepsis have higher than normal concentrations of plasminogen activator inhibitor 1 ( PAI 1 ) in plasma . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Furthermore , suppression of cyclin D 1 expression with a cyclin D 1 antisense cDNA resulted in loss of TGF beta 1 mediated growth inhibition in association with reduced induction of cyclin D 1 , p 21 ( C ) ( ip ) ( 1 ) and plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The plasminogen activator inhibitors 1 ( PAI 1 ) and 2 ( PAI 2 ) are two specific inhibitors of u PA . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Blood levels of lipoproteins , glucose , iron and transferrin , fibrinogen , tissue plasminogen activator ( t PA ) antigen level and activity and plasminogen activator inhibitor ( PAI 1 ) antigen level and activity were also determined . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor type 1 ( PAI 1 ) , a serine protease inhibitor , affects the processes of fibrinolysis , wound healing , and vascular remodeling . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
It is known that angiotensin 2 ( Ang 2 ) exerts an antifibrinolytic effect by stimulating synthesis of plasminogen activator inhibitor type 1 ( PAI 1 ) , a specific inhibitor of tissue plasminogen activator ( t PA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Urokinase plasminogen activator ( uPA ) and plasminogen activator inhibitor 1 ( PAI 1 ) expression was determined by enzyme linked immunosorbent assay . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The urokinase type plasminogen activator ( uPA ) system plays an important role in tumor cell invasion , metastases , and angiogenesis . uPA , uPA receptor , and plasminogen activator inhibitor 1 ( PAI 1 ) are prognostic factors in different solid tumors , e . g . , renal cell carcinomas ( RCCs ) . von Hippel Lindau ( VHL ) disease is an inherited cancer syndrome that is characterized by extensively vascularized tumors , including hemangioblastomas and RCCs . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To further investigate the role of plasminogen activator inhibitor 1 ( PAI 1 ) in adipose tissue physiology , the production and regulation of PAI 1 was determined in primary cultures of human preadipocytes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
One of these involves the decrease in plasma levels of plasminogen activator inhibitor type 1 ( PAI 1 ) , the main inhibitor of fibrinolysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Cysteine proteases [ Cathepsin B and L ( CATB , CATL ) ] and the serine protease urokinase type plasminogen activator ( UPA ) with its inhibitor type 1 ( PAI 1 ) are thought to play an important part in colorectal cancer invasion and metastasis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A drastic up regulation of the expression of the mRNA for plasminogen activator inhibitor 1 ( PAI 1 ) , which is known as an inhibitor for fibrinolysis , may explain the suppression of the bleeding tendency . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have tried to answer this question by measuring DNA polymorphisms of selected cardiovascular risk indicators [ factor 7 , FVII ( R / Q353 , intron 7 ( 37bp ) n , and 323ins10 ) , beta fibrinogen ( 455G / A ) , plasminogen activator inhibitor type 1 , PAI 1 ( 675 ( 4G / 5G ) ) , tissue plasminogen activator , t PA ( intron 8 ins 311 ) , platelet receptor glycoprotein IIb / IIIa , GPIIb / IIIa ( L / P33 ) , prothrombin ( 20210G / A ) , methylene tetrahydrofolate reductase , MTHFR ( A / V114 ) , angiotensin converting enzyme , ACE ( intron 16 ins 287 ) , and angiotensinogen ( M / T235 ) ] . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Regular exercise , plasminogen activator inhibitor 1 ( PAI 1 ) activity and the 4G / 5G promoter polymorphism in the PAI 1 gene . ^^^ The aim of this controlled randomised clinical trial was to investigate the effects of regular low to moderate intensity physical activity on plasminogen activator inhibitor 1 ( PAI 1 ) activity during three years while taking into account the 4G / 5G polymorphism in the promoter of the PAI 1 gene . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Thereby , human peritoneal mesothelial cells ( HMC ) play an important role in maintaining the balance between the peritoneal generation and degradation of fibrin by expressing the fibrinolytic enzyme tissue type plasminogen activator ( t PA ) as well as the specific plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have examined the association of four candidate genes , angiotensin converting enzyme ( ACE ) : insertion / deletion ( I / D ) polymorphism , plasminogen activator inhibitor 1 ( PAI 1 ) : 4G / 5G polymorphism , decorin : 179 / 183 / 185 polymorphism and Werner syndrome helicase : C / R polymorphism , with the presence of diabetic nephropathy in Type 1 diabetic patients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : Recent reports link C . pneumoniae infection of arteriosclerotic lesions to the precipitation of acute coronary syndromes , which also feature tissue factor and plasminogen activator inhibitor 1 ( PAI 1 ) overexpression . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Here we demonstrate that induction of the cholesterol metabolic pathway by growth of embryonic chicken atrial cells in medium supplemented with lipoprotein depleted serum coordinately decreased the expression of the TGFbeta type 2 receptor ( TGFbetaRII ) , TGFbeta ( 1 ) , and TGFbeta signaling as measured by plasminogen activator inhibitor 1 ( PAI 1 ) promoter activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : The effects of iloprost infusion on plasminogen activator inhibitor type 1 ( PAI 1 ) , glucometabolic control and cardiovascular equilibrium in patients with type 2 diabetes mellitus and peripheral arterial occlusive disease were investigated . ^^^ Plasma levels of glucose , plasminogen , PAI 1 activity and fibrinogen , blood pressure and heart rate were determined in all studies , while plasma insulin levels , blood HbA ( 1c ) , walking distance and Winsor index only in studies 3 and IV . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To identify regions responsible for ligand recognition , soluble receptor fragments containing the eight cysteine rich class A repeats were produced . ( 125 ) 1 RAP and ( 125 ) 1 labeled urokinase type plasminogen activator : plasminogen activator inhibitor type 1 ( uPA : PAI 1 ) complexes bound to the soluble fragment with K ( D , app ) values of 0 . 3 and 14 nM , respectively . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
PURPOSE : To study interactions between disease free survival ( DFS ) and four components of the plasminogen activator system : urokinase type plasminogen activator ( uPA ) , its two inhibitors ( PAI 1 and PAI 2 ) , and its membrane receptor uPAR . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : Cathepsin B ( CATB ) and cathepsin L ( CATL ) , which are cysteine proteases , urokinase ( UPA ) and tissue type plasminogen activator ( TPA ) , both serine proteases , and their inhibitor type 1 ( PAI 1 ) are believed to play an important role in colorectal carcinoma ( CRC ) invasion and metastasis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue type plasminogen activator ( tPA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) antigen concentrations were measured by ELISA . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The present morphological study was therefore designed to investigate the occurrence and distribution of the tissue and urokinase plasminogen activators ( t PA and u PA ) , the u PA receptor ( u PAR ) and the plasminogen activator inhibitors ( PAI 1 and PAI 2 ) in normal human testis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Hemostasis markers measured thrombin antithrombin complexes ( TAT ) , fibrinogen , plasmin alpha 2 antiplasmin complexes ( PAP ) , plasminogen activator inhibitor ( PAI 1 ) , and D dimer . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
During acute and chronic inflammatory lung diseases , the normal fibrinolytic activity in the alveolar space is inhibited by increased levels of plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Type 1 plasminogen activator inhibitor ( PAI 1 ) , a major physiological inhibitor of plasminogen activation , is an important component of the hepatic acute phase response . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We examined the mRNA levels of estrogen receptor ( ER ) , progesterone receptor ( PR ) , estrogen inducible pS 2 and plasminogen activator inhibitor 1 ( PAI 1 ) in 23 cell lines derived from benign and malignant breast tissues using a competitive reverse transcription polymerase chain reaction ( cRT PCR ) system . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Here we report that glucocorticoid receptor ( GR ) represses TGF beta transcriptional activation of the type 1 plasminogen activator inhibitor ( PAI 1 ) gene in a ligand dependent manner . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODOLOGY : We immunohistochemically examined 97 colorectal carcinomas for the expression of urokinase type plasminogen activator ( uPA ) and plasminogen activator inhibitor 1 ( PAI 1 ) to investigate whether uPA and PAI 1 expressions could serve as prognostic parameters ; the gene expression of uPA and PAI 1 in human colon cancer tissues was also analyzed using reverse transcription polymerase chain reaction ( RT PCR ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The mediators of the plasminogen activator system , namely urokinase type plasminogen activator ( u PA ) , tissue type plasminogen activator ( t PA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) , are a key complex involved in fibrinolysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Addition of plasminogen promoted uPA activity in both normal and OA osteoblasts via a positive feedback loop due to plasmin generation , since this activity was inhibited by both PAI 1 and alpha 2 antiplasmin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To investigate the effect of insulin on fibrinolysis , we evaluated levels of plasminogen activator inhibitor 1 ( PAI 1 ) and tissue plasminogen activator ( tPA ) antigens during insulin infusion in the forearm vascular beds of 8 healthy subjects . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
MAIN OUTCOME MEASURES : Tissue type plasminogen activator ( t PA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Furthermore , synthesis of plasminogen activator inhibitor 1 ( PAI 1 ) , and to a weak extent that of fibronectin , were inhibited in endoglin transfectants . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Urokinase plasminogen activator ( u PA ) and its fast acting type 1 inhibitor ( PAI 1 ) localize to cellular focal adhesive structures and the adjoining proximal undersurface region , respectively ( Kutz et al . , J . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) ] . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Substitution of the native variable region 1 ( VR1 / 37 loop ) of thrombin by the corresponding VR 1 of tissue type plasminogen activator ( thrombin VR 1 ( tPA ) ) increases the rate of inhibition by plasminogen activator inhibitor type 1 ( PAI 1 ) by three orders of magnitude , and is thus sufficient to confer PAI 1 specificity to a heterologous serine protease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The cofactors heparin , vitronectin ( VN ) , and thrombomodulin ( TM ) modulate the reactivity of alpha thrombin with plasminogen activator inhibitor ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Changes in the expression of this system , consisting of urokinase and tissue type plasminogen activators ( uPA and tPA , respectively ) , plasminogen activator inhibitors ( PAI 1 , PAI 2 ) and uPA receptor , have been associated with tumour aggressiveness in a variety of solid malignant tumours . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Gene expression for plasminogen activator inhibitor 1 ( PAI 1 ) , urokinase and tissue plasminogen activators ( uPA and tPA ) , urokinase plasminogen activator receptor ( uPAR ) , and transforming growth factor beta 1 ( TGF beta 1 ) was examined by Northern analysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Circulating plasminogen activator inhibitor 1 ( PAI 1 ) levels are elevated in patients with coronary heart disease and may play an important role in atherothrombosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Increased plasma levels of coagulation proteins such as fibrinogen and plasminogen activator inhibitor 1 ( PAI 1 ) are associated with an increased risk of myocardial infarction . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We investigated the production by leukaemic cells of plasminogen activators [ urokinase ( uPA ) and tissue type PA ( tPA ) ] , cell surface receptor for uPA ( uPAR ) and PA inhibitors ( PAI 1 and PAI 2 ) . ^^^ The finding of uPA , uPAR , PAI 1 and PAI 2 synthesized by leukaemic cells suggests that plasminogen activation may contribute to the invasive behaviour of these cells , the fibrinolytic imbalance observed in leukaemic patients and the differentiation and proliferation of M 4 M5 by interaction of uPA with uPAR . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The generated single site changed plasminogen activator inhibitor 1 ( PAI 1 ) mutants were expressed in Escherichia coli and purified by heparin Sepharose and anhydrotrypsin agarose chromatographies . ^^^ The PAI 1 mutants His143Asp and His143Phe only displayed about 20 % of the specific activity obtained for wtPAI 1 , because they , to a large extent , act as substrates for tissue type plasminogen activator . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The primary goal of this investigation was to see whether plasminogen activator inhibitor 1 ( PAI 1 ) concentrations varied as a function of differences in insulin mediated glucose disposal in 2 groups of healthy women matched for every other variable that might play a role in regulation of PAI 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVES : To measure tumor necrosis factor alpha ( TNF alpha ) and interleukin 1beta ( IL 1beta ) in pleural effusions caused by tuberculosis ( TB ) and malignancy and their relationship with plasminogen activator inhibitor type 1 ( PAI 1 ) and tissue type plasminogen activator ( tPA ) , and to compare the differences between tuberculous and malignant pleural effusions . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Cell conditioned medium was assayed for tissue type plasminogen activator ( t PA ) , urokinase type plasminogen activator ( u PA ) , and plasminogen activator inhibitor type 1 ( PAI 1 ) by enzyme linked immunosorbent assay . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma levels of type 1 plasminogen activator inhibitor ( PAI 1 ) , a risk factor for cardiovascular disease , are elevated in obese subjects , especially those with omental fat accumulation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In RT PCR experiments , tissue type PA ( tPA ) mRNA levels in both aged hGF and rGF were higher than in young cells , whereas plasminogen activator inhibitor 1 ( PAI 1 ) mRNA remained unchanged and urotype PA ( uPA ) mRNA was not detected . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Value of p 53 , urokinase plasminogen activator , PAI 1 and Ki 67 in vulvar carcinoma ] . ^^^ OBJECTIVE : The present study was to measure new prognostic factors including the plasminogen activator urokinase and the plasminogen inhibitor PAI 1 , as well as p 53 and Ki 67 , a marker of proliferation and to compare the clinical value of these in relation to the classic histopathological prognostic factors . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVES : The study was done to assess whether the common polymorphic allele ( 4G ) of the plasminogen activator inhibitor 1 ( PAI 1 ) gene is associated with coronary artery disease ( CAD ) or myocardial infarction ( MI ) . ^^^ Plasminogen activator inhibitor 1 plays a central role in intravascular thrombosis and thrombolysis ; the common insertion / deletion polymorphism ( 4G / 5G ) of PAI 1 has been correlated with altered PAI 1 levels and proposed as a coronary risk factor . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In all patients levels of total cholesterol , triglyceride , HDL cholesterol , LDL cholesterol , lipoprotein ( a ) ( Lpa ) C reactive protein ( CRP ) , fibrinogen , thrombin / antithrombin 3 complex ( TAT ) , plasminogen activator inhibitor type 1 ( PAI 1 ) , tissue plasminogen activator ( t PA ) and von Willebrand antigen were measured . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To investigate the influence of a 4G / 5G polymorphism in the PAI 1 gene promoter and environmental factors on plasma plasminogen activator inhibitor 1 ( PAI 1 ) levels in subjects with essential hypertension . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Total cholesterol , apolipoprotein A 1 ( apo A 1 ) , apolipoprotein B ( apo B ) , plasminogen activator inhibitor ( PAI 1 ) , insulin , and leptin were analysed in stored samples . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Increased factor VIIc ( FVIIc ) and plasminogen activator inhibitor type 1 ( PAI 1 ) levels may lead to a thrombotic state and subsequently to a higher risk of myocardial infarction . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is the primary physiological inhibitor of both tissue type and urokinase type plasminogen activators . ^^^ The balance between plasminogen activators and PAI 1 plays an important role in several physiological and pathophysiological processes such as atherosclerosis or thrombosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) functions as an important regulator of fibrinolysis by inhibiting both tissue type and urokinase type plasminogen activator . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The focus was on the impact of physical activity on platelet aggregation , fibrinogen , and plasminogen activator inhibitor 1 ( PAI 1 ) in overweight and obese subjects . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We , therefore , tested the hypothesis that intravascular fibrin deposition in situ directly obstructs cerebral microcirculation and that local changes in type 1 plasminogen activator inhibitor ( PAI 1 ) gene expression contribute to intravascular fibrin deposition after embolic MCA occlusion . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
MEASUREMENTS : Plasma concentrations of oestradiol ( E ) , dehydroepiandrosterone sulphate ( DHEA S ) , total testosterone ( T ) , FSH , PRL , sex hormone binding globulin ( SHBG ) , type 1 procollagen propeptide ( PICP ) and the cross linked carboxyterminal telopeptide of type 1 collagen ( ICTP ) , total cholesterol , HDL cholesterol , triglycerides ( TG ) , apolipoprotein ( apo ) A 1 , apo B , lipoprotein ( a ) [ Lp ( a ) ] , fibrinogen , factor VIIc and plasminogen activator inhibitor 1 ( PAI 1 ) were evaluated with commercially available kits . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This study was aimed at evaluating the relationship between visceral fat accumulation and plasma plasminogen activator inhibitor 1 ( PAI 1 ) levels in healthy , obese men and women undergoing weight loss therapy . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the present study , we demonstrate that brain natriuretic peptide ( BNP ) and C type natriuretic peptide ( CNP ) interact with angiotensin 2 ( Ang 2 ) in regulative blood coagulation and fibrinolysis by suppressing the expressions of both tissue factor ( TF ) and plasminogen activator inhibitor 1 ( PAI 1 ) induced by Ang 2 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Immunological quantitation of rabbit plasminogen activator inhibitor 1 in biological samples : evidence that rabbit platelets do not contain PAI 1 . ^^^ Two immunoassays for the specific quantitation of rabbit plasminogen activator inhibitor 1 ( PAI 1 ) antigen and activity in biological samples were developed and applied for the evaluation of PAI 1 in rabbits . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In this study , we investigated the effects of angiotensin metabolites on the mRNA expression of tissue factor ( TF ) , tissue factor pathway inhibitor ( TFPI ) , plasminogen activator inhibitor 1 ( PAI 1 ) , and tissue type plasminogen activator ( TPA ) in cultured rat aortic endothelial cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Western analysis was used to assess changes in p 53 , p21WAF , p16INK4a , cyclin D 1 and plasminogen activator inhibitor 1 ( PAI 1 ) levels at senescence . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
For the patients with ' medium baseline values ' , total plasminogen activator inhibitor 1 ( PAI 1 ) and t PA PAI 1 complex levels decreased , while the changes in lipids and lipoproteins were not significant after amlodipine treatment . ^^^ For the patients with ' high baseline values ' , the mean triglyceride and very low density lipoprotein cholesterol ( VLDLC ) levels were reduced while the reductions in total and free PAI 1 and the increase in tissue plasminogen ( t PA ) levels were not significant after amlodipine treatment . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
MATERIALS AND METHODS : In the present study , we determined the plasma concentrations of tissue type plasminogen activator ( tPA ) , urokinase type plasminogen activator ( uPA ) , plasminogen activator inhibitor 1 ( PAI 1 ) , PAI 2 , and uPA receptor ( uPAR ) in 25 patients with ovarian cancer , 16 patients with benign gynecologic tumor or inflammation , and 36 healthy controls in order to find out whether the plasma levels of these markers could be used to evaluate the prognostic value in patients with gynecologic cancers . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have examined the serum levels of the plasminogen activator inhibitor type 1 ( PAI 1 ) antigen and activity , tissue plasminogen activator ( t PA ) antigen and activity , soluble thrombomodulin ( sTM ) , and tissue factor pathway inhibitor ( TFPI ) before and after reaching the target blood pressure ( < 140 / 90 mm Hg ) in 13 hypertensive patients receiving perindopril ( mean age 40+ / 11 years , 6 women , 7 men ) and in 12 patients receiving losartan ( mean age 38+ / 9 years , 6 women , 6 men ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The fibrinolytic potential was measured by whole blood clot lysis time ( WBCLT ) , tissue plasminogen activator , and plasminogen activator inhibitor 1 ( PAI 1 ) antigens in plasma . ^^^ Acute exercise caused an immediate rise in both tissue plasminogen activator antigen and PAI 1 antigen levels and WBCLT was significantly shortened . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is the only functionally labile serpin , as it converts spontaneously into a non reactive ' latent ' conformation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Additionally , we considered the secretion of urokinase type plasminogen activator ( uPA ) , plasminogen activator inhibitor 1 and 2 ( PAI 1 and PAI 2 ) , as well as matrix metalloproteinases ( MMP ) 1 , 2 , 3 , and 9 , and their inhibitors TIMP 1 and TIMP 2 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fibrinolytic PMC activity was detected by zymography for tissue plasminogen activator ( tPA ) and by reverse zymography for plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : We evaluated assays to measure both total tissue plasminogen activator ( tPA ) and the three principle forms of tPA in plasma : active tPA , tPA complexed with plasminogen activator inhibitor type 1 ( PAI 1 ) , and tPA complexed with C 1 inhibitor . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Induced expression of plasminogen activator inhibitor type 1 ( PAI 1 ) , a major negative regulator of pericellular plasmin generation , accompanies wound repair in vitro and in vivo . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Compared with endothelial cells , the trophoblast lining decidual spiral arteries have a reduced capacity to lyse fibrin , and recent studies have shown this to be caused by high levels of plasminogen activator inhibitors ( PAI 1 and PAI 2 ) . ^^^ Cytotrophoblast cells isolated from the placenta and placental bed from IUGR pregnancies express significantly higher levels of PAI 1 , coupled with a significant decrease in plasminogen activator activity , compared with trophoblast cells from normal pregnancy maintained in culture . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fibrinolytic factors such as tissue plasminogen activator ( t PA ) , plasminogen activator inhibitor type 1 ( PAI 1 ) , and t PA PAI 1 complex ( PAI C ) of specimens were measured by enzyme linked immunoassay . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This study was designed to test whether plasma levels of tissue plasminogen activator ( tPA ) , plasminogen activator inhibitor 1 ( PAI 1 ) , and tPA / PAI 1 complex could predict a first ever stroke . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Epidemiologic information suggests that plasminogen activator inhibitor 1 ( PAI 1 ) , a central regulator of the fibrinolytic system , plays an important role in determining the overall risk for clinically significant vascular thrombosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We studied 428 patients ( 44 % men ) and measured blood levels of fibrinogen , plasminogen activator inhibitor 1 ( PAI 1 ) , tissue plasminogen activator antigen ( t PA ) , plasma viscosity , von Willebrand factor , D dimer and platelet count , both at baseline and after 90 days of daily immersion . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Markedly elevated plasminogen activator inhibitor type 1 ( PAI 1 ) levels prior to treatment , reflecting a reduced fibrinolytic potential , decreased rapidly under PC substitution . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Moreover , human recombinant MIF upregulated the expression of urokinase plasminogen activator inhibitor 1 ( PAI 1 ) precursor mRNA in human osteoblastic Saos 2 cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
MAIN OUTCOME MEASURES : Trends across quintiles of fasting insulin in levels of plasminogen activator inhibitor 1 ( PAI 1 ) antigen , tissue type plasminogen activator ( tPA ) antigen , von Willebrand factor ( vWF ) antigen , factor 7 antigen , fibrinogen , and plasma viscosity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Although previous work has focused on the effect of angiotensin 2 ( Ang 2 ) on plasminogen activator inhibitor ( PAI 1 ) expression , the present study tests the hypothesis that aldosterone contributes to the regulation of PAI 1 expression . ^^^ PAI 1 antigen , but not tissue plasminogen activator antigen , concentrations were significantly higher in adrenal venous blood than in peripheral venous blood . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Increasing levels of alcohol consumption were associated with increases in tPA and plasminogen activator inhibitor ( PAI 1 ) activity and with decreases in fibrinogen and white cell count . tPA , PAI 1 , fibrinogen ( nephelometric ) , and viscosity were positively associated with body mass index . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Genotype frequency of plasminogen activator inhibitor 1 ( PAI 1 ) 4G / 5G polymorphism in healthy Japanese males and its relation to PAI 1 levels . ^^^ Plasminogen activator inhibitor 1 ( PAI 1 ) plays an inhibitory role in the fibrinolytic enzyme system and is associated with thrombotic diseases . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
By comparison , the mRNAs of the proteinase inhibitors , plasminogen activator inhibitor 1 ( PAI 1 ) and tissue inhibitor of metalloproteinase ( TIMP ) were 5x greater than that of control rats on day 4 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) , the major circulating inhibitor of urokinase [ urokinase type plasminogen activator ( uPA ) ] , has been linked to the pathogenesis of lung cancer . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : Von Willebrand factor ( vWF ) and the fibrinolytic factors tissue plasminogen activator ( tPA ) , measured as tPA capacity , and plasminogen activator inhibitor 1 ( PAI 1 ) , platelets , fibrinogen , and inflammatory markers were measured in 74 patients with active seropositive RA . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : Plasminogen activator inhibitor 1 ( PAI 1 ) is a key regulator of fibrinolytic pathway and extracellular matrix ( ECM ) turnover . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) may participate in the development of cardiovascular remodeling by inhibiting extracellular matrix turnover and fibrinolysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We therefore investigated during the phorbol ester ( phorbol 12 myristate 13 acetate ( PMA ) ) induced monocyte / macrophage differentiation of the human HL 60 leukemia cells , if TNFalpha contributed to plasminogen activator inhibitor type 1 ( PAI 1 ) synthesis that is initiated by a protein kinase Cbeta extracellular signal regulated kinase 2 dependent pathway ( Lopez , S . , Peiretti , F . , Morange , P . , Laouar , A . , Fossat , C . , Bonardo , B . , Huberman , E . , Juhan Vague , I . , and Nalbone , G . ( 1999 ) Thromb . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The association between drug resistance and three markers for invasive capacity : cathepsin D ( Cath D ) , urokinase type plasminogen activator ( uPA ) and inhibitor of plasminogen activator type 1 ( PAI 1 ) was examined in nine cervical and laryngeal carcinoma cell lines resistant to different cytostatics . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
DEVELOPMENT : The conditions related to increased risk of thrombosis are : the congenital thrombophilias due to deficiency of protein C , protein S or antithrombin 3 , resistance to protein C activated by Leiden ' s factor 5 cofactor of protein C with genetic mutation ; the primary antiphospholipid syndrome with anticardiolipin antibodies and lupus inhibitor ; platelet disorders , deficit of heparin cofactor 2 , deficit of plasminogen and plasminogen tissue activator ( t PA ) and increase in the inhibitor of plasminogen tissue activator ( PAI 1 ) ; alterations in factors of coagulation such as deficits of factor 7 and factor 13 , mutation of prothrombin 20210 > A , increase in factor 8 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
On both occasions plasma total cholesterol , LDL C , HDL C , triglycerides , lipoprotein [ a ] ( Lp [ a ] ) , tissue plasminogen activator ( tPA ) , plasminogen activator inhibitor 1 ( PAI 1 ) , antithrombin 3 ( AT 3 ) , plasminogen and fibrinogen were determined just before the meal ( t 0 ) and at times 2 hours , 4 h , 6 h , 8 h after it ( t 2 t8 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : Fibrinogen , prothrombin fragment F1+2 , D dimer , and plasminogen activator inhibitor type 1 ( PAI 1 ) activity was determined in 10 patients who underwent open ( group A ) and 10 patients who underwent VLPS cholecystectomy ( group B ) , respectively . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
RESULTS : Birth weight was inversely associated ( p < 0 . 03 ) with subscapular : triceps skinfold ratio ( truncal fat ) , plasminogen activator inhibitor 1 ( PAI 1 ) activity , specific insulin and proinsulin like molecules when adjusted for BMI . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
While abnormalities in plasma fibrinolytic activity have been described in diabetic retinopathy , platelets ( a rich source of plasminogen activator inhibitor type 1 , PAI 1 ) have received little attention . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma plasminogen activator inhibitor 1 ( PAI 1 ) levels are elevated in insulin resistant subjects and are associated with increased cardiovascular risk of atherothrombosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Six animals each were treated either with conventional or with GDCs coated with a mixture of tissue thromboplastin to enhance intra aneurysmal thrombus formation and of plasminogen activator inhibitor type 1 ( PAI 1 ) in inhibit intra aneurysmal clot fibrinolysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activators u PA ( urokinase ) and t PA ( tissue ) as well as the inhibitors PAI 1 and PAI 2 are present in gingival crevicular fluid in concentrations significantly greater than in plasma . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Parameters monitored included blood loss , prothrombin F1 . 2 , thrombin antithrombin complexes , t PA , PAI 1 , plasminogen , fibrin D dimer , and plasma factor 13 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We examined whether statins altered expression of the major determinants of fibrinolytic balance , plasminogen activator inhibitor 1 ( PAI 1 ) , and tissue type plasminogen activator ( tPA ) in human vascular smooth muscle ( SMC ) and endothelial ( EC ) cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In this report we compared the mechanism by which nitric oxide ( NO ) , generated exogenously and endogenously , affects the plasminogen activator inhibitor type 1 ( PAI 1 ) expression in endothelial cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Expression of the plasminogen activator system and the inhibitors PAI 1 and PAI 2 in posttraumatic lesions of the CNS and brain injuries following dramatic circulatory arrests : an immunohistochemical study . ^^^ To study this supposition , we investigated immunohistochemically the expression of tPA , uPA and its receptor , the plasminogen activator inhibitors PAI 1 and PAI 2 , tetranectin as well as the laminin breakdown as an event of secondary brain injury . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We studied tissue plasminogen activator ( t PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) levels in plasma and peritoneal effluent in 10 children on continuous ambulatory peritoneal dialysis ( CAPD ) before , and 8 and 12 weeks after , treatment with recombinant human erythropoietin ( rHuEPO ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the latter , the protein kinase C agonist phorbol myristate acetate transiently enhanced tissue factor ( TF ) mRNA levels and elicited a more prolonged elevation in TF protein levels , but did not affect plasminogen activator inhibitor 1 ( PAI 1 ) mRNA and protein levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Antigen levels of tissue type plasminogen activator ( tPA ) and plasminogen activator inhibitor ( PAI 1 ) were comparable with young endothelial cells , and mRNA was present for tPA , PAI 1 , tissue factor ( TF ) , tissue factor pathway inhibitor and thrombomodulin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To better understand the regulation of tissue plasminogen activator ( t PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) during liver transplantation , we used a computer model of the human circulatory system to simultaneously evaluate the effect of t PA secretion , t PA inhibition by PAI 1 , hepatic clearance of t PA , blood loss , transfusion and hemodynamics on t PA and PAI 1 levels during liver transplantation in three patients that differed in severity of liver disease , blood loss and anhepatic changes in t PA . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
These results , combined with recent studies of the tumor metastasis suppressor gene KAI 1 and plasminogen activator inhibitor 1 ( PAI 1 ) , define a new category of molecular targets of p 53 that have the potential to negatively regulate tumor invasion and / or metastasis . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The serpin plasminogen activator inhibitor type 1 ( PAI 1 ) is an important protein in the regulation of fibrinolysis and inhibits its target proteinases through formation of a covalent complex . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Coagulation fibrinolysis parameters determined were D dimer ( DD ) , thrombin antithrombin 3 complex ( TAT ) , tissue plasminogen activator ( TPA ) , and plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor type 1 ( PAI 1 ) and its role in cardiovascular disease . ^^^ Reduced endogenous fibrinolytic activity secondary to increased plasma activity of plasminogen activator inhibitor type 1 ( PAI 1 ) is now considered as a new cardiovascular risk factor . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS AND RESULTS : We investigated 20 patients ( M / F = 15 / 5 ; mean age = 36 . 7 years ) with angiographically proven CAD for their plasma levels of tissue type plasminogen activator ( t PA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) at basal conditions as well as after VO and at maximal ES ( standardised bicycle stress test ) and compared the data to those obtained from 12 sex and age matched healthy controls ( M / F = 9 / 3 ; mean age = 40 . 4 years ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A series of conjugates containing residues of lipophilic alcohols covalently bound to 5 ' end of oligodeoxyribonucleotides targeted against human plasminogen activator inhibitor ( PAI 1 ) mRNA was synthesized via the oxathiaphospholane approach . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Intracellular infection of endothelial cells with Rickettsia rickettsii results in increased steady state levels of plasminogen activator inhibitor 1 ( PAI 1 ) mRNA . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To determine whether changes in subcutaneous adipose tissue plasminogen activator inhibitor 1 ( PAI 1 ) expression influence plasma PAI 1 level during weight loss in obese humans . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the solid tumor , urokinase type plasminogen activator ( uPA ) , plasminogen activator inhibitor type 1 ( PAI 1 ) and uPA receptor ( uPAR ) are considered as prognostic factors . ^^^ We have found that the plasminogen activation system ( uPA , PAI 1 , uPAR ) of tumor tissue is activated from the early stage of breast cancer . ^^^ The blood level of the plasminogen activation system correlated with that of tissue in an order of uPAR ( r ( 2 ) =0 . 61 ; P=0 . 001 ) , uPA ( r ( 2 ) =0 . 35 ; P=0 . 001 ) and PAI 1 ( r ( 2 ) =0 . 11 ; P=0 . 001 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Using a series of DNA array membranes , we identified a group of hypoxia induced genes that included plasminogen activator inhibitor 1 ( PAI 1 ) , insulin like growth factor binding protein 3 ( IGFBP 3 ) , endothelin 2 , low density lipoprotein receptor related protein ( LRP ) , BCL 2 interacting killer ( BIK ) , migration inhibitory factor ( MIF ) , matrix metalloproteinase 13 ( MMP 13 ) , fibroblast growth factor 3 ( FGF 3 ) , GADD 45 , and vascular endothelial growth factor ( VEGF ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor type 1 ( PAI 1 ) is the primary inhibitor of plasminogen activation and has been proposed to promote atherosclerosis by facilitating fibrin deposition within developing lesions . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Elevated levels of plasminogen activator inhibitor type 1 ( PAI 1 ) are found in advanced atherosclerotic plaque compared with normal vessel and may contribute to plaque progression and complications associated with plaque rupture . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In this article , the regulation of plasminogen activator inhibitor 1 ( PAI 1 ) expression in rat aortic smooth muscle cells ( RASMCs ) by adenine and uridine nucleotides was examined and compared . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Impaired fibrinolysis due to elevated levels of plasminogen activator inhibitor type 1 ( PAI 1 ) is a risk factor for atherothrombotic disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Measurements of fasting triglycerides and antigen concentrations of tissue type plasminogen activator ( t PA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) were also included . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The present study was performed to analyze the relationship between portal hypertension and alterations of the endothelium derived proteins thrombomodulin , plasminogen activator ( t PA ) and plasminogen activator inhibitor ( PAI 1 ) , which were determined in plasma samples of 28 alcoholic cirrhotic patients and 46 controls . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The following polymorphisms were studied : apolipoprotein B ( apo B ) signal peptide insertion / deletion polymorphism , 5 ' apolipoprotein ( a ) [ apo ( a ) ] TTTTA repeat polymorphism , apolipoprotein E ( apo E ) varepsilon 2 , varepsilon 3 , varepsilon 4 polymorphism , and plasminogen activator inhibitor 1 ( PAI 1 ) 4G / 5G promoter polymorphism . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Aliquots of glomeruli were used for RNA preparation and for culture to determine 72 hour production of TGF beta , fibronectin and plasminogen activator type 1 ( PAI 1 ) , which were assayed by ELISA on culture supernatants . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We also evaluated the relationships between FDR and several cardiovascular risk factors or markers of inflammatory response or endothelial activation , for example , duration of dialysis , BP , smoking habits , cholesterol , parathormone ( PTH ) , serum albumin , plasma fibrinogen , C reactive protein ( CRP ) , plasma homocysteine , plasminogen activator inhibitor ( PAI 1 ) , and von Willebrand factor ( vWF ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Chronic exposure of endothelial cells to homocysteine also increases the expression of two surface molecules linked to vascular disease , intracellular adhesion molecule 1 ( ICAM 1 ) and plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Neither the production of urokinase nor the conversion of pro urokinase to the active , two chain form was elevated by KOD , but it decreased plasminogen activator inhibitor 1 ( PAI 1 ) activity of cells and inactivated PAI 1 irreversibly in a purified system . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We investigated the production of TGF beta 1 , the biological effects of TGF beta and neutralizing antibody on HCC cells , activation of Smad 2 , Smad 3 , and Smad 4 , induction of antagonistic Smads ( Smad 6 and Smad 7 ) , and promoter activities of two target genes , plasminogen activator inhibitor type 1 ( PAI 1 ) and p15INK4B . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The concentrations of tissue plasminogen activator ( t PA ) , urokinase plasminogen activator ( u PA ) , and plasminogen activator inhibitor type 1 ( PAI 1 ) in cell conditioned medium were determined by ELISA and the level of PAI 1 mRNA was determined using northern hybridisation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma plasminogen activator inhibitor ( PAI 1 ) activity was significantly increased in diabetic animals . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The crystal structure of a constitutively active multiple site mutant of plasminogen activator inhibitor 1 ( PAI 1 ) was determined and refined at a resolution of 2 . 7 A . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) has been reported in greater concentration in GB stone bile and may be a nucleating factor in the pathogenesis of GB stone formation . ^^^ Tissue plasminogen activator ( t PA ) and PAI 1 of choledochal bile were measured by enzyme linked immunosorbent assay in patients with cholangitis due to acalculous bile duct obstructions ( n = 9 ) , choledocholithiasis with cholangitis ( n = 20 ) , and normal bile ( n = 7 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In situ hybridization and immunocytochemical localization were used to define the cellular and tissue distribution of urokinase plasminogen activator ( uPA ) , plasminogen activator inhibitor type 1 ( PAI 1 ) and 2 ( PAI 2 ) and urokinase receptor in early monkey placenta and uterus . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Elevated plasma level of plasminogen activator inhibitor 1 ( PAI 1 ) in patients with relapsing remitting multiple sclerosis . ^^^ We determined the plasma level of plasminogen activator inhibitor 1 ( PAI 1 ) , a key regulator of fibrinolysis and cell migration , in patients with MS . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The low density lipoprotein receptor related protein ( LRP ) is a multiligand clearance receptor that removes free tissue type plasminogen activator ( t PA ) or complexes of t PA with plasminogen activator inhibitor type 1 ( PAI 1 ) from the blood circulation or the pericellular space . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Gender and the 4G / 5G polymorphism in the plasminogen activator inhibitor 1 ( PAI 1 ) gene are believed to play a role in the regulation of plasma PAI 1 activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Attachment to vitronectin was also inhibited in a dose dependent manner by the type 1 plasminogen activator inhibitor ( PAI 1 ) , a serine protease inhibitor . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : Plasminogen activator inhibitor type 1 ( PAI 1 ) plays a key role in fibrinolytic activity , which is important for thrombotic cardiovascular events . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
After 4 weeks ' dietary intervention fasting plasma factor 7 coagulant ( FVIIc ) activity , tissue type plasminogen activator ( t PA ) activity , plasminogen activator inhibitor ( PAI 1 ) antigen and beta thromboglobulin did not differ between diets M and D . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Serp 1 inhibits plasminogen activators in a manner similar to plasminogen activator inhibitor ( PAI 1 ) , a vascular protein that plays a pivotal regulatory role in vascular wound healing . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Among the various plasma coagulation and fibrinolysis factors that are found to be altered in diabetes , the increased level of plasminogen activator inhibitor ( PAI 1 ) in the plasma and in the vessel wall is of the utmost importance . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Increased production of plasminogen activator inhibitor 1 ( PAI 1 ) has been implicated in the development of thrombosis and atherosclerosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
On the other hand , the Y99L mutation has no effect on the activity of tPA toward the natural substrate plasminogen , that carries Gly at P 2 , and reduces more than 10 fold the inhibition of tPA by plasminogen activator inhibitor 1 ( PAI 1 ) , that carries Ala at P 2 . ^^^ In addition , residue Y 99 plays an active role in the recognition of PAI 1 , but not plasminogen . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
PURPOSE : To identify in the adult and developing rodent eye cells expressing the gene encoding plasminogen activator inhibitor 1 ( PAI 1 ) , an important component of the fibrinolytic system . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We hypothesized that the introduction of fixed low dose warfarin alone or in combination with aspirin ( 300 mg ) could normalize hemostatic markers , namely plasma fibrin D dimer ( an index of thrombogenesis ) , plasminogen activator inhibitor 1 ( PAI 1 , an index of fibrinolysis ) , fibrinogen , and von Willebrand factor ( vWf , an index of endothelial dysfunction ) , in a manner comparable to adjusted dose warfarin ( target INR 2 . 0 to 3 . 0 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
PURPOSE : To determine the ability of radiation to modulate kidney tubule epithelial cell expression of various molecules involved in regulating extracellular matrix accumulation ( collagen types 1 and 3 , fibronectin , plasminogen activator inhibitor 1 ( PAI 1 ) , TGF beta and tissue inhibitor of metalloproteinases 2 ( TIMP 2 ) ) and degradation ( plasminogen activators u PA or t PA , MMP 2 and MMP 9 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) has a central role in the regulation of the fibrinolytic enzyme system . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) was cleaved at its C terminus by reptilase and lost its specific activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The urokinase type plasminogen activator system ( uPAS ) , consisting of the urokinase plasminogen activator ( uPA ) , the uPA receptor ( uPA R ) , and their corresponding inhibitors , PAI 1 and PAI 2 , is thought to play a role in this process . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma levels of fibrinogen , tissue plasminogen activator ( t PA ) , and plasminogen activator inhibitor 1 ( PAI 1 ) were measured on admission and discharge . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The preliminary results of other studies on the effects of 4 HPR on tissue plasminogen activator ( t PA ) , plasminogen activator inhibitor 1 ( PAI 1 ) , and urokinase plasminogen activator ( uk PA ) and on the relevance of circulating p 53 antibodies with relapse will be also presented . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Raised plasminogen activator inhibitor 1 ( PAI 1 ) is not an independent risk factor in the polycystic ovary syndrome ( PCOS ) . ^^^ BACKGROUND : It has been postulated that an insulin driven increase in plasminogen activator inhibitor 1 ( PAI 1 ) levels may link insulin resistance to anovulatory infertility in women with PCOS and that it may place them at increased risk of thromboembolic disease . ^^^ MEASUREMENTS : PAI 1 activity , insulin , glucose , triglycerides , total cholesterol , LDL cholesterol , HDL cholesterol , FSH , LH , PRL , testosterone , SHBG , 17 hydroxyprogesterone , plasminogen , fibrinogen ( alpha 2 antiplasmin , blood pressure and insulin sensitivity with a homeostasis model assessment ( HOMA ) computer programme . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the last decade various groups have reported a strong and statistically independent prognostic impact of the serine protease uPA ( urokinase type plasminogen activator ) and its inhibitor PAI 1 ( plasminogen activator inhibitor type 1 ) in node negative breast cancer patients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
After long term follow up , the prognostic impact of the following proteolytic factors associated with tumor invasion and metastasis was evaluated in 276 primary breast cancer patients : uPA ( urokinase type plasminogen activator ) , PAI 1 ( uPA inhibitor type 1 ) , and cathepsins B , D and L . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
By using immunofluorescence confocal microscopy , we demonstrate that the antigens of thrombin , plasminogen activator inhibitor 1 ( PAI 1 ) , and vitronectin ( Vn ) colocalize in human neointimal atherosclerotic arterial tissue . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In this study , we determined whether hypoxia in the range of that observed in pathophysiological hypoxic states stimulates plasminogen activator inhibitor 1 ( PAI 1 ) production in bovine aortic endothelial cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Type 1 plasminogen activator inhibitor ( PAI 1 ) , the primary inhibitor of tissue type plasminogen activator ( t PA ) , circulates as a complex with the abundant plasma glycoprotein , vitronectin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Activity of plasminogen activator inhibitor ( PAI 1 ) , platelet adhesion and aggregation , antigens of tissue and urokinase plasminogen activators ( respectively , t PA Ag and u PA Ag ) , euglobulin lysis time ( ELT ) , complexes of plasmin antiplasmin ( PAP ) and fibrin degradation products ( FDP ) were tested before and after fourteen days administration of 20 30 mg / d prednisone . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In HTG , basal fibrinolytic activity , ie tissue plasminogen activator ( t PA ) activity , was impaired as a result of high plasminogen activator inhibitor type 1 ( PAI 1 ) antigen and activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
AIMS / HYPOTHESIS : Increased plasma plasminogen activator inhibitor 1 ( PAI 1 ) concentrations are characteristic for subjects with insulin resistance and could contribute to the increased cardiovascular risk in this state . ^^^ Plasminogen activator inhibitor 1 protein was measured by ELISA , PAI 1 mRNA by a semiquantitative RT PCR technique . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Troglitazone , a novel oral insulin sensitizer , normalizes increased plasma activity of plasminogen activator inhibitor type 1 ( PAI 1 ) in hyperinsulinemic patients such as women with polycystic ovary syndrome and patients with type 2 diabetes mellitus . ^^^ In human endothelial cells , PAI 1 was diminished by 32 % ( P < 0 . 001 ) , whereas tissue type plasminogen activator was unaffected . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To clarify the role of rhEPO in the development of stenosis of AV fistulae , this study examined expression of the erythropoietin receptor ( EPO R ) , TGF beta 1 , plasminogen activator inhibitor type 1 ( PAI 1 ) , cellular fibronectin containing an extra domain A ( EDA+ ) , and TGF beta 1 mRNA , and assessed in situ rhEPO binding in tissue specimens from seven cutaneous veins and eight patent and seven stenosed portions of AV fistulae of patients undergoing dialysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
MDCK cells transformed by LMP 1 showed invasive growth to form branching tubules into collagen gel without HGF treatment . mRNA differential display and Northern hybridization identified plasminogen activator inhibitor 1 ( PAI 1 ) , urokinase type plasminogen activator ( uPA ) and ets 1 as genes upregulated during transformation by LMP 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
High plasma plasminogen activator inhibitor 1 ( PAI 1 ) activity is a frequent finding in obesity and adipose tissue has recently been suggested to be a source of circulating PAI 1 in humans . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Previously , we found a relationship between plasminogen activator inhibitor Type 1 ( PAI 1 ) and lipoprotein ( a ) [ Lp ( a ) ] in Type 2 diabetes mellitus patients without complications . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The antigen of urokinase type plasminogen activator ( u PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) were measured by ELISA , and u PA activity was evaluated by electrophoretic enzymography . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To determine EGR 1 functions , we re expressed EGR 1 in human glioblastoma U 251 cells and found that the secretion of transforming growth factor beta 1 ( TGF beta 1 ) , plasminogen activator inhibitor 1 ( PAI 1 ) , and fibronectin ( FN ) was greatly enhanced . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
MAIN OUTCOME MEASURE ( s ) : Expression of the messenger ribonucleic acid ( mRNA ) of tissue type plasminogen activator ( t PA ) and that of a specific PA inhibitor type 1 ( PAI 1 ) in endometrial tissue samples , as evaluated with the use of Northern blot analysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The child was homozygous for the 4G allele of the plasminogen activator inhibitor 1 ( PAI 1 ) 4G / 5G promoter polymorphism . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Expression of nerve growth factor induced type 1 plasminogen activator inhibitor ( PAI 1 ) mRNA is inhibited by genistein and wortmannin . ^^^ Nerve growth factor ( NGF ) , which acts as a neurotrophic factor in a rat pheochromocytoma cell line ( PC 12 ) , stimulated type 1 plasminogen activator inhibitor ( PAI 1 ) mRNA expression from 1 to 5 h , after addition at 5 ng / ml . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The aim of this study was to establish whether patients with GHD , like those with CVD , show an increase in fibrinogen ( FBG ) , type 1 plasminogen activator inhibitor ( PAI 1 ) , acute phase response proteins ( APR ) , and soluble adhesion molecules . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The identification of the Hind 3 polymorphic site in the 3 ' end of the plasminogen activator inhibitor 1 ( PAI 1 ) gene and a simple method to identify the Hind 3 polymorphism rapidly in the PAI 1 gene using PCR is described . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Adult human saphenous vein endothelial cells ( HVEC ) were cultured in a compliant tubular device and evaluated by Northern hybridization for the effects of combined pressurized pulsatile flow and cyclic strain on the expression of mRNAs for endothelin 1 ( ET 1 ) , endothelial cell nitric oxide synthase ( ecNOS ) , tissue plasminogen activator ( tPA ) , and plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Endogenous fibrinolytic activity is predominantly regulated by the plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^ In addition , endothelial cells synthesize and secrete substantial amounts of plasminogen activators and their inhibitor PAI 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
RESULTS : We used a recently developed method for making precise distance measurements , based on donor donor energy migration ( DDEM ) , to accurately triangulate the position of the protease urokinase type plasminogen activator ( uPA ) in complex with the serpin plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In view of the potential importance of the proteolytic mechanisms in the evolution of MS lesions , the authors studied the 4G / 5G promoter polymorphism of the plasminogen activator inhibitor 1 ( PAI 1 ) gene in the susceptibility of MS . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Vascular endothelial cells ( ECs ) modulate the blood fibrinolytic system by secreting tissue type plasminogen activator ( t PA ) , urokinase type plasminogen activator ( u PA ) , and their inhibitor , type 1 plasminogen activator inhibitor ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Total fibrinolytic activity in the vasculature is finely tuned by the balance between tissue plasminogen activator and plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^ Although PAI 1 targets plasminogen activators , it also reacts with other serine proteases such as thrombin and factor Xa . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To study the link between IL 10 and fibrinolysis in vivo , the induction of plasminogen activator inhibitor 1 ( PAI 1 ) was evaluated . ^^^ Northern analysis demonstrated exaggerated pulmonary PAI 1 expression in IL 10 ( / ) mice after I / R , with a corresponding increase in plasma PAI / tissue type plasminogen activator activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma tissue type plasminogen activator ( tPA ) and plasminogen activator inhibitor ( PAI 1 ) and lipoprotein ( a ) [ Lp ( a ) ] in 133 healthy subjects were determined . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A deletion / insertion polymorphism ( 4G or 5G ) in the promoter of the plasminogen activator inhibitor type 1 ( PAI 1 ) gene is suggested to be involved in regulating the synthesis of the inhibitor , 4G allele , being associated with the enhanced gene expression and plasma PAI 1 levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Among these individuals , we evaluated the role of polymorphisms of the plasminogen activator inhibitor 1 ( PAI 1 ) gene in the thrombophilic phenotype . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : A point mutation in the plasminogen activator inhibitor 1 ( PAI 1 ) gene and a three allelic variation in the apolipoprotein E ( ApoE ) gene have been suggested as risk factors for the development of diabetic micro and macrovascular complications . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : Urokinase type plasminogen activator ( uPA ) , its receptor ( uPAR ) and plasminogen activator inhibitors ( PAI 1 and PAI 2 ) , all play important roles in tumour invasion and metastasis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma fibrinogen , antithrombin 3 , von Willebrand factor , tissue plasminogen activator ( tPA ) , plasminogen activator inhibitor 1 ( PAI 1 ) prothrombin time , and activated partial thromboplastin time were determined using standard methods . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) has been found to be a bad prognostic factor in a number of tumours but the reason has not been fully explained . ^^^ This indicated that the inhibitory activity of PAI 1 was required for its anti apoptotic effect but the urokinase type plasminogen activator receptor was not involved . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
CPB and GE accelerated plasminogen activator inhibitor 1 ( PAI 1 ) inactivation , and TTB caused direct , reversible inhibition of PAI 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
However , 10 days of treatment with HCT significantly increased plasminogen activator inhibitor 1 ( PAI 1 ) antigen ( 26 . 8 + / 5 . 8 5 21 . 1 + / 3 . 4 ng / mL [ p = . 037 ] ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Furthermore , the levels of secreted plasminogen activator inhibitor 1 ( PAI 1 ) were markedly higher , while no apparent differences were seen in the levels of active uPA and tPa between EGF R ( / ) and wild type pancreata . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor type 1 ( PAI 1 ) is the primary inhibitor of endogenous plasminogen activators that generate plasmin in the vicinity of a thrombus to initiate thrombolysis , or in the pericellular region of cells to facilitate migration and / or tissue remodeling . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To examine the effects of the inclusion of extruded dry beans in the diet on serum lipoprotein , plasma fibrinogen , plasma viscosity and plasminogen activator inhibitor 1 ( PAI 1 ) levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
However , no significant differences between the two periods were seen in factor 7 coagulant activity ( FVIIc ) , fibrinogen , prothrombin fragments 1+2 ( F1+2 ) , tissue plasminogen activator ( tPA ) plasminogen activator inhibitor 1 ( PAI 1 ) or 2 , 3 , dinor thromboxane B 2 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Transcriptional activation of plasminogen activator inhibitor type 1 ( PAI 1 ) was impaired in four of the six mutants due to the defects in homo and / or hetero oligomerization with wild type Smads . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Some monoclonal antibodies against plasminogen activator inhibitor 1 ( PAI 1 ) are able to inhibit its reaction with its target proteinases . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The purpose of this study was to evaluate the effects of 4 HPR on uPA and plasminogen activator inhibitor 1 ( PAI 1 ) in prostate cancer . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
High plasma levels of fibrinogen and plasminogen activator inhibitor ( PAI 1 ) are reported to be correlated with coronary heart disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
It was found that cadmium promotes the synthesis of plasminogen activator inhibitor 1 ( PAI 1 ) whereas lead inhibits the synthesis of tissue plasminogen activator ( t PA ) in vascular endothelial cells ; consequently , both heavy metals reduced fibrinolytic activity in the liquid phase . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Blood samples for endotoxin , plasminogen activator inhibitor 1 ( PAI 1 ) activity , tissue type plasminogen activator ( t PA ) antigen , and cross linked fibrin degradation products ( XL FDP ) were drawn before , during , and 7 days after surgery . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Before and after treatment , glycemic control , steady state plasma glucose and insulin ( SSPG and SSPI , respectively ) , and markers of fibrinolysis ( tissue plasminogen activator [ tPA ] and plasminogen activator inhibitor 1 [ PAI 1 ] ) were analyzed in each patient . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Elevated levels of plasminogen activator inhibitor 1 ( PAI 1 ) are characteristic of the obese state and may contribute to the association between obesity and cardiovascular disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The obese subjects presented significantly elevated values for insulin ( P < . 001 ) , tissue plasminogen activator ( [ t PA ] P < . 001 ) , plasminogen activator inhibitor 1 ( [ PAI 1 ] P < . 001 ) , and fibrinogen ( P < . 001 ) with respect to the control group . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
HBx did not affect TGF beta induced activation of promoter activities of the plasminogen activator inhibitor 1 ( PAI 1 ) gene . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We investigated effects of the angiotensin converting enzyme ( ACE ) inhibitor imidapril and the angiotensin 2 type 1 ( AT 1 ) antagonist candesartan cilexetil on cardiac plasminogen activator inhibitor 1 ( PAI 1 ) expression in rats . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
ELISA for tissue type plasminogen activator ( t PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) in the culture media indicated that OSF increased the bFGF induced release of PAI 1 antigen , but not of t PA antigen . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Since reported data have indicated that plasminogen activators ( uPA and tPA ) were able to excise the angiostatin fragment from the plasminogen parent molecule via plasmin generation , we determined levels of uPA and tPA and PAI 1 antigen in the conditioned media , and correlated the results with angiostatin generating capacity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
While data concerning a number of parameters remain contradictory , high levels of type 1 plasminogen activator inhibitor ( PAI 1 ) and lipoprotein ( a ) and hyper homocystinemia appear to play a significant role in the pathogenesis of this disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is a unique member of the serpin family , as it spontaneously converts into a latent conformation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Elevated levels of plasminogen activator inhibitor 1 ( PAI 1 ) are characteristic for obesity and are associated with increased risk of thromboembolic complications . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Elevated levels of plasminogen activator inhibitor 1 ( PAI 1 ) with and without reduction of tissue plasminogen activator ( tPA ) in plasma have been frequently found in patients with DM . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Proteins influencing plasminogen activation to plasmin , namely plasminogen activators tissue type plasminogen activator ( t PA ) and urokinase type plasminogen activator ( u PA ) and their principal inhibitors , plasminogen activator inhibitor 1 ( PAI 1 ) and PAI 2 , were measured in the plasma , the polymorph and mononuclear cell fractions taken from patients with major sepsis who were entering a general intensive care unit . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In this report we have studied the conformation of the reactive centre of plasminogen activator inhibitor type 1 ( PAI 1 ) mutants with inhibitory and substrate properties . ^^^ The distances found were 57+ / 4 A and 63+ / 3 A , respectively , which is comparable to the distance obtained between the same residues when PAI 1 is in complex with urokinase type plasminogen activator ( uPA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Euglobulin lysis time ( ELT ) , tissue plasminogen activator activity ( t PA : act ) and antigen ( t PA : Ag ) , PAI 1 activity ( PAI 1 : act ) , and antigen ( PAI 1 : Ag ) were assayed on blood samples drawn before and 20 min after the venous occlusion test ( VO ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Cytokines and oxygen centered free radicals implicated in insulin resistance stimulate adipocyte and endothelial production of plasminogen activator inhibitor type 1 ( PAI 1 ) , the primary physiologic inhibitor of fibrinolysis , in vitro . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The present study demonstrated that glycation enhanced Lp ( a ) induced production of plasminogen activator inhibitor 1 ( PAI 1 ) , and further decreased the generation of tissue type plasminogen activator ( t PA ) from human umbilical vein endothelial cells ( HUVEC ) and human coronary artery EC . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Oviductal plasminogen activator inhibitor 1 ( PAI 1 ) : mRNA , protein , and hormonal regulation during the estrous cycle and early pregnancy in the pig . ^^^ Recent identification of plasminogen activator inhibitor 1 ( PAI 1 ) in the pig oviduct has prompted an evaluation of its mRNA , protein synthesis , and hormonal regulation during the estrous cycle and early pregnancy , defined as time prior to and after maternal recognition of pregnancy . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
One of the proteolytic systems produced by bone cells is the plasminogen activator / plasmin pathway , which involves the two plasminogen activators and the type 1 plasminogen activator inhibitor ( PAI 1 ) and results in plasmin generation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BTEB 2 also activates a number of vascular disease associated genes , such as tissue factor , PAI 1 ( plasminogen activator inhibitor 1 ) , and Egr 1 gene . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In this chapter , we summarize our studies on plasminogen activator inhibitor 1 ( PAI 1 ) , tissue factor , and transforming growth factor beta ( TGF beta ) expression in obesity , using genetically obese mice as a model . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
High plasminogen activator inhibitor 1 ( PAI 1 ) levels are associated with an increased cardiovascular risk of atherothrombosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The role of the 13 histidine residues in plasminogen activator inhibitor 1 ( PAI 1 ) for the stability of the molecule was studied by replacing these residues by threonine , using site directed mutagenesis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Low plasma fibrinolytic activity in association with increased plasma plasminogen activator inhibitor 1 ( PAI 1 ) levels has been linked to an increased risk of atherosclerosis in obesity and type 2 diabetes . ^^^ We assessed insulin sensitivity ( 5 h , 80 mU 10 m ( 2 ) 10 min ( 1 ) hyperinsulinemic euglycemic clamp ) and measured plasma PAI 1 antigen and activities and tissue plasminogen activator ( tPA ) in 14 patients with type 2 diabetes and 20 normal control subjects ( 10 lean , 10 obese ) before and after 3 months of treatment with troglitazone ( 600 mg / day ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In order to elucidate the relationship between homocysteine and the fibrinolytic system , we examined the effect of homocysteine on plasminogen activator inhibitor 1 ( PAI 1 ) and tissue type plasminogen activator ( tPA ) gene expression and protein secretion in cultured human vascular endothelial and smooth muscle cells in vitro . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Elevated levels of plasminogen activator inhibitor 1 ( PAI 1 ) can reduce the efficiency of the endogenous fibrinolytic system . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Immunofluorescence and quantitative immunofluorescence with antibodies against alpha smooth muscle actin , desmin , matrix metalloproteinases 2 ( MMP 2 ) , MMP 9 , tissue inhibitor of metalloproteinases 1 ( TIMP 1 ) and 2 ( TIMP 2 ) , urokinase type plasminogen activator ( u PA ) and its inhibitor 1 ( PAI 1 ) were studied with confocal microscopy . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Local intracoronary delivery of recombinant adenoviruses expressing anti migratory or anti proliferative proteins including human constitutive endothelial nitric oxide synthase ( NOS 3 ) , plasminogen activator inhibitor 1 ( PAI 1 ) , or herpesvirus thymidine kinase ( TK ) ( combined with ganciclovir ) was used to prevent neointimal formation in porcine coronary arteries . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The role of plasminogen activator inhibitor 1 ( PAI 1 ) in the plasma , blood platelets , and vessel wall during acute arterial thrombus formation was investigated in gene deficient mice . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In addition to analyses of t PA binding to plasminogen activator inhibitor 1 ( PAI 1 ) in the extracellular matrix ( ECM ) and to the t PAR , we further evaluated the binding of three t PA mutants , deltaFE1X t PA lacking finger ( F ) , epidermal growth factor like ( E ) domains and one sugar chain at Asn 177 thus comprising two kringles ( K 1 and K 2 ) and protease ( P ) domains , deltaFE3X t PA with three glycosylation sites deleted at Asn 117 , 184 , and 448 , and deltaFEK 1 t PA comprising K 2 and P domains without glycosylation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To evaluate the status of hemostatic factors , fibrinogen , tissue plasminogen activator ( tPA ) antigen level , plasminogen activator inhibitor 1 ( PAI 1 ) antigen level , and PAI 1 activity were assessed . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fibrinopeptide A ( FP A ) , D Dimer , plasminogen activators ( PA ) of the urokinase ( u PA ) or tissue type ( t PA ) , PA inhibitor 1 ( PAI 1 ) and alpha 2 antiplasmin ( alpha 2 AP ) were determined by ELISA technique . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the adult epidermis , keratinocytes do not normally express the type 1 inhibitor of plasminogen activator ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The defects found were as follows : antiphospholipid syndrome , 67 % ; sticky platelet syndrome , 21 % ; tissue plasminogen activator ( TPA ) deficiency , 9 % ; factor 5 Leiden , 7 % ; high PAI 1 , 6 % ; protein S , 5 % ; high LP ( a ) , 3 % ; AT , 2 % ; protein C , 1 % . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The aim of the study was to analyse the role of cathepsin D and plasminogen activator inhibitor 1 ( PAI 1 ) expression as independent prognosticators and to assess their predictive value with respect to tamoxifen treatment . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Additionally , the activity of type 1 plasminogen activator inhibitor ( PAI 1 ) in the intrapleural lavage fluid ( ILF ) was measured at 24 hours postoperatively because this is the main influence on adhesion formation after surgery . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The serine protease inhibitor plasminogen activator inhibitor 1 ( PAI 1 ) is synthesized and released from human adipose tissue ex vivo and regulates smooth muscle and endothelial cell migration in vitro , but its role in adipose tissue is not known . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue plasminogen activator antigen ( t PA Ag ) and tissue plasminogen activator inhibitor ( PAI 1 ) in the course of hemodialysis in patients with chronic renal failure ] . ^^^ In 10 patients with chronic renal insufficiency we are tissue plasminogen activator antigen ( t PA Ag ) , tissue plasminogen activator inhibitor ( PAI 1 ) and euglobulin lysis time ( ELT ) designed . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Four gene mutations ( factor 5 Leiden , methylenetetrahydrofolate reductase [ MTHFR ] , prothrombin , and 4G / 5G polymorphism of the plasminogen activator inhibitor type 1 [ PAI 1 ] gene ) were assessed by polymerase chain reaction ( PCR ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have studied the serpin , plasminogen activator inhibitor 1 ( PAI 1 ) , in both the active and the latent state and found that anionic halide ions may play a role in the active to latent structural transition . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The concentration of the glycoprotein plasminogen activator inhibitor 1 ( PAI 1 ) is raised in insulin resistance . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In adipose tissue from both obese mice and humans , plasminogen activator inhibitor 1 ( PAI 1 ) expression has been reported to be upregulated to levels of increased plasma PAI 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
She also had familial hypofibrinolysis with 4G4G polymorphism of the plasminogen activator inhibitor ( PAI 1 ) gene and high PAI 1 activity ( PAI Fx ) , 42 . 5 U / mL , normal < 21 . 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The effects of fluvastatin , a synthetic hydroxymethylglutaryl coenzyme A ( HMG CoA ) inhibitor , on the biosynthesis of tissue plasminogen activator ( t PA ) and of its major physiological inhibitor ( plasminogen activator inhibitor type 1 , PAI 1 ) were investigated in cultured human umbilical vein endothelial cells ( HUVEC ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) 4G / 5G polymorphism , coronary thrombosis , and myocardial infarction in middle aged Finnish men who died suddenly . ^^^ High plasminogen activator inhibitor 1 ( PAI 1 ) plasma levels increase future risk of myocardial infarction ( MI ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We studied the expression of uPA , urokinase plasminogen activator receptor ( uPAR ) and plasminogen activator inhibitor type 1 ( PAI 1 ) in human breast carcinomas and their bone metastases , using in situ hybridisation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Elevated plasminogen activator inhibitor 1 ( PAI 1 ) levels are associated with venous thromboembolism , although their significance is unclear . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma tissue plasminogen activator ( t PA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) antigen and activity were measured at baseline and 6 hours after the dose . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Urokinase type plasminogen activator ( uPA ) and plasminogen activator inhibitor 1 ( PAI 1 ) have been reported as prognostic factors in breast cancer patients and plasminogen activation is regulated by various factors such as uPAR and growth factors . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To elucidate the role of the plasminogen activator inhibitor 1 ( PAI 1 ) in bone turnover in vivo , bone metabolism was analyzed in mice deficient in the expression of PAI 1 gene ( PAI 1 / ) at baseline ( 8 week old mice ) and 4 weeks after ovariectomy ( OVX ) or sham operation ( Sham ) and compared with wild type ( WT ) mice . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma levels of thrombin antithrombin ( TAT ) complexes , tissue plasminogen activator ( t PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) activities were measured using commercially available kits . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The aim of this study was to test the hypothesis that plasma levels of plasminogen activator inhibitor type 1 ( PAI 1 ) and interleukin 6 ( IL 6 ) in children at the time of diagnosis of HUS would predict renal function outcome in terms of glomerular filtration rate ( GFR ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
It has been demonstrated in vitro that lipoprotein ( a ) [ Lp ( a ) ] increases the endothelial synthesis of plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma levels of : von Willebrand Factor ( vWF ) , thrombomodulin , plasminogen activity inhibitor type 1 ( PAI 1 : antigen and activity ) , tissue type plasminogen activator ( t PA : antigen ) , prothrombin fragment 1+2 ( F1+2 ) and thrombin antithrombin complexes ( TAT ) were measured previously to CRRT ( base line ) , and after 24 and 48 hours of therapy . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The plasminogen activation system also includes the serpins PAI 1 and PAI 2 , and the uPA receptor ( uPAR ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
For this purpose , the presence and enzymatic activity of matrix metalloproteinases ( MMP 2 , MMP 9 ) , tissue inhibitors of MMPs ( TIMP 1 , TIMP 2 ) , urokinase type ( uPA ) and tissue type ( tPA ) plasminogen activators ( PAs ) , and plasminogen activator inhibitor 1 ( PAI 1 ) were quantified by western blot and gelatin or plasminogen casein zymography . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The balance between urokinase type plasminogen activator and plasminogen activator inhibitor 1 is modified ; RNA and catalytic activity for the former are elevated while PAI 1 RNA is reduced . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To study plasminogen activator inhibitor 1 ( PAI 1 ) gene expression and protein synthesis in fibrotic liver tissues and plasma activity levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Several studies have demonstrated an increased level of plasma plasminogen activator inhibitor 1 ( PAI 1 ) in patients with coronary artery disease ( CAD ) . ^^^ The concentrations of plasma PAI 1 , tissue plasminogen activator ( t PA ) , and t PA 10 PAI 1 complex were similar in the CAD ( ) and CAD ( + ) groups , but were greater on day 1 in the AMI group compared with the 2 CAD groups . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A potential interaction between the cell death and extracellular matrix remodelling is evident from the observation that IGFBP 5 binds to plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^ We thus hypothesized that IGFBP 5 could activate cell death by sequestration of IGF 1 and activate plasminogen cleavage by sequestering PAI 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Neither the morphology of the cells nor the secretion of prostacyclin ( PGI 2 ) , von Willebrand factor ( vWF ) , tissue plasminogen activator ( t PA ) and plasminogen activator inhibitor ( PAI 1 ) was affected by the crosslink density of the collagen substrate . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Since little is known about the evaluation of markers of haemostatic and fibrinolytic systems in other adrenal disorders , we studied plasminogen activator inhibitor ( PAI 1 ) , tissue plasminogen activator ( t PA ) , fibrinogen and von Willebrand factor antigen ( vWF Ag ) levels in 11 patients with Cushing ' s syndrome and in 12 patients with adrenal incidentaloma . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Erythropoietin ( EPO ) mimetic peptide ( EMP ) encoding sequence was inserted into the gene of plasminogen activator inhibitor 1 ( PAI 1 ) between Ala 348 and Pro 349 ( P2 ' P 3 ' ) , generating a novel gene , PAI 1 / EMP ( PMP ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) gene 4G / 5G promoter polymorphism is not associated with breast cancer . ^^^ The antigen content of plasminogen activator inhibitor 1 ( PAI 1 ) in primary breast cancer tissue extracts may be of strong prognostic value : high levels of PAI 1 in tumors predict poor prognosis for patients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Methods and results : Hypertensive status , antihypertensive drug treatment , total and high density lipoprotein ( HDL ) cholesterol , triglyceride , apoproteins A 1 and B , lipoparticles LpA 1 , LpE : B and Lp ( a ) , fibrinogen , plasminogen activator inhibitor 1 ( PAI 1 ) activity and factor 7 were assessed in a sample of men 50 59 years living in France ( n = 7050 ) and Northern Ireland ( n = 2374 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Concentrations of plasminogen activator ( tPA ) and plasminogen activator inhibitor 1 ( PAI 1 ) as measures of the fibrinolytic activity of mesothelial cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
High density mutagenesis by combined DNA shuffling and phage display to assign essential amino acid residues in protein protein interactions : application to study structure function of plasminogen activation inhibitor 1 ( PAI 1 ) . ^^^ To validate the procedure , human plasminogen activator inhibitor 1 ( PAI 1 ) was chosen , because its 3D structure is known , many experimental tools are available and it may serve as a model protein for structure function studies of serine proteinases and their inhibitors ( serpins ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Matrix metalloproteinase 3 ( MMP 3 or stromelysin 1 ) specifically hydrolyzes the Ser ( 337 ) Ser ( 338 ) ( P 10 P9 ) and Val ( 341 ) Ile ( 342 ) ( P 6 P5 ) peptide bonds in human plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^ At an enzyme / substrate ratio of 1 / 10 at 37 degrees C , PAI 1 protein cleavage occurred with half lives of 27 or 14 min for active or stable PAI 1 and was associated with rapid loss of inhibitory activity toward tissue type plasminogen activator with half lives of 15 or 13 min , respectively . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The 4G / 4G genotype at nucleotide position 675 in the promotor region of the plasminogen activator inhibitor 1 ( PAI 1 ) gene is less frequent in young patients with minor stroke than in controls . ^^^ The insertion / deletion polymorphism ( 4G / 5G ) in the promotor region of the plasminogen activator inhibitor 1 ( PAI 1 ) gene has been associated with an increased risk of myocardial infarction . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NO production , physiologic parameters , and histology were studied in addition to the mRNA expression of TGF beta 1 , plasminogen activator inhibitor 1 ( PAI 1 ) and the matrix proteins biglycan and collagens type 1 and 4 by Northern and the protein expression of PAI 1 and fibronectin by enzyme linked immunosorbent assay . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Currently , data concerning plasminogen activator inhibitor type 1 ( PAI 1 ) expression in the ligated kidney are unavailable . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Based on recent findings linking activation of the RAAS with impaired fibrinolytic balance , we hypothesized that aldosterone induces sclerosis through effects on plasminogen activator inhibitor 1 ( PAI 1 ) , the major physiological inhibitor of plasminogen activation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Previously , we showed that a similar arrangement between a SBE and an E box of an element is essential for TGF beta dependent transcription of the plasminogen activator inhibitor 1 gene ( PAI 1 ) and that TGF beta induced phosphorylation of Smad 3 triggers its association with TFE 3 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The aims of the study were to determine the acute effect of angiotensin 2 and bradykinin on the local vascular release of tissue plasminogen activator ( t PA ) and its inhibitor , plasminogen activator inhibitor type 1 ( PAI 1 ) , and the endothelium derived haemostatic factor , von Willebrand factor ( vWf ) from the forearm . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The plasminogen activator inhibitor type 1 ( PAI 1 ) has an essential role in tissue remodeling . ^^^ The functional significance of PAI 1 secretion was demonstrated by complete inhibition of tissue type plasminogen activator activity with supernatants of stimulated HMC 1 cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Different factors affect pHo , but it remains unclear whether pHo are genetically determined and whether they are related to other risk markers , such as the angiotensin 1 converting enzyme ( ACE ) and the plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The renin angiotensin system is now recognized to be linked to induction of plasminogen activator inhibitor 1 ( PAI 1 ) , possibly via the AT ( 4 ) receptor , thus promoting both thrombosis and fibrosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
It leads to the identification of plasminogen activator inhibitor 1 or PAI 1 as a new target for tumor treatment . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This distinct pattern appears identical in the genomic structures of human plasminogen activator inhibitor 1 ( PAI 1 ) at 7q21 and protease nexin 1 ( PI 7 ) at 2q33 35 , confirming that these four genes in three different chromosomes form a discrete subset within the serpin superfamily . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
APC plays an important role in regulating blood coagulation and fibrinolysis by inhibiting not only blood coagulation factors Va and VIIIa but also type 1 plasminogen activator inhibitor ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The serine protease urokinase type plasminogen activator ( uPA ) , its inhibitor ( PAI 1 ) , and its receptor ( uPAR ; CD 87 ) facilitate cancer cell invasion and metastasis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Experimental and clinical research supports a direct link between activation of the renin angiotensin system and production of plasminogen activator inhibitor 1 ( PAI 1 ) , the primary physiologic inhibitor of tissue plasminogen activator . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
When overexpressed in primary MC , GFAT produced a two to threefold increase in the activity of plasminogen activator inhibitor 1 ( PAI 1 ) promoter . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor type 1 ( PAI 1 ) plays a critical role in vascular pathophysiology both at the intra and extravascular levels . ^^^ We therefore investigated the effects of atorvastatin ( ATOR ) and fluvastatin ( FLU ) on PAI 1 and also tissue type plasminogen activator ( t PA ) synthesis in 20 % fetal calf serum cultured human umbilical vein endothelial cells ( HUVEC ) stimulated or not by recombinant human pro inflammatory cytokines , i . e . tumor necrosis factor alpha ( TNFalpha ) and interleukin 1alpha ( IL 1alpha ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A rapid reversed phase HPLC assay is described for quantitating recombinant plasminogen activator inhibitor type 1 ( PAI 1 ) in cultures of Escherichia coli . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Since the urokinase type plasminogen activator ( uPA ) initiates this cascade , this hypothesis was tested by investigating the effects of noncytotoxic levels of nickel subsulfide on the balance of uPA expression relative to expression of its inhibitor , PAI 1 , in cultured human bronchial epithelial cells ( BEAS 2B ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : Preoperative plasma plasminogen activator inhibitor 1 ( PAI 1 ) is a prognostic variable in patients with colorectal cancer . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Urokinase type plasminogen activator ( uPA ) and its receptor ( uPAR ) , plasminogen ( Plg ) , and plasminogen activator inhibitors 1 and 2 ( PAI 1 and PAI 2 ) have been observed in many cancers and may contribute to progression and metastasis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To investigate whether HRT use induces a procoagulant state , we undertook a prospective cohort study in postmenopausal women to investigate the effects of 3 months of treatment with oral HRT ( conjugated equine estrogen 0 . 625 mg daily and medroxyprogesterone 2 . 5 mg daily ) on markers of thrombin generation ( prothrombin fragment 1+2 , thrombin antithrombin complexes ) , fibrinolytic potential ( plasminogen activator inhibitor 1 ( PAI 1 ) activity ) , and activated protein C ( APC ) resistance . ^^^ There was a consistent pattern of increased fibrinolytic potential with HRT use associated with one marker ( PAI 1 ) , but not with another marker ( tissue plasminogen activator antigen ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : In 20 patients with RP ( in all patients secondary to SSc ) and in 10 controls the levels of thrombomodulin ( TM ) , beta thromboglobulin ( beta TG ) , D dimer ( DD ) , tissue type plasminogen activator ( t PA ) and plasminogen activator inhibitor ( PAI 1 ) were measured in venous plasma samples taken at 9 . 00 and 14 . 00 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND / AIMS : The detailed role of type 1 plasminogen activator inhibitor ( PAI 1 ) in liver with ischemia reperfusion injury remains unclear . ^^^ Peripheral blood was taken perioperatively and PAI 1 , tissue type plasminogen activator ( tPA ) , plasma aspartate aminotransferase ( AST ) and cytokine levels were measured . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have used immunohistochemistry to examine three components of this system , ie , uPA , uPA receptor ( uPAR ) , and plasminogen activator inhibitor 1 ( PAI 1 ) , in a pilot study on 142 cases of breast carcinoma . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Subcutaneous adipose tissue expression of plasminogen activator inhibitor 1 ( PAI 1 ) in nondiabetic and Type 2 diabetic subjects . ^^^ OBJECTIVE : Increased plasma levels of plasminogen activator inhibitor 1 ( PAI 1 ) have been suggested to be a part of the insulin resistance syndrome , and recent data suggest that adipose tissue participates in the production of PAI 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The interaction of fibrinolytic components with GPIb / V / IX of platelets on thrombus formation , was investigated in mice deficient in tissue type ( tPA / ) , urokinase type plasminogen activator ( uPA / ) or plasminogen activator inhibitor 1 ( PAI 1 / ) and in their wild type control ( tPA+ / + , uPA+ / + , PAI 1+ / + ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We studied the effect of LDL ( ) on the release by ECs of molecules implicated in leukocyte recruitment [ interleukin 8 ( IL 8 ) and monocyte chemotactic protein 1 ( MCP 1 ) ] and in the plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Although the renin angiotensin system has been implicated in increasing plasminogen activator inhibitor 1 ( PAI 1 ) expression , the role of the angiotensin type 1 ( AT ( 1 ) ) receptor is controversial . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To investigate the relationship between the 4G / 5G polymorphism of the type 1 plasminogen activator inhibitor ( PAI 1 ) gene and thrombotic manifestations in patients with antiphospholipid syndrome ( APS ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The purpose of this study was to evaluate the changes in tissue plasminogen activator ( t PA ) , plasminogen activator inhibitor type 1 ( PAI 1 ) and D dimer ( DD ) antigen plasma levels in acute myocardial infarction ( AMI ) patients after thrombolytic therapy with two different thrombolytic agents , rt PA or acetyl streptokinase and to find out any correlation between the plasma t PA , PAI 1 and DD levels with the infarct size as it is estimated from the peak of serum CPK levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The plasminogen activator inhibitor type 1 ( PAI 1 ) , as the main inhibitor of plasminogen activation , regulates fibrinolysis and the plasmin mediated matrix metalloproteinase activation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To investigate whether the course of primary melanoma disease correlates with expression of the various components of the proteolytic plasminogen activation ( PA ) system , immunohistochemical stainings for activators of plasminogen ( tissue type ( tPA ) and urokinase type ( uPA ) ) , inhibitors of plasminogen activation ( type 1 ( PAI 1 ) and type 2 ( PAI 2 ) ) and the receptor for uPA ( uPAR ) were performed on 214 routinely processed melanoma lesions . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Blood samples were collected at the beginning and at the end of each dietary period from fasted subjects for determination of factor 7 coagulant activity ( FVIIc ) , activated factor 7 ( FVIIa ) , factor 7 antigen ( FVIIag ) , tissue plasminogen activator ( tPA ) activity , plasminogen activator inhibitor type 1 ( PAI 1 ) activity , fibrinogen , prothrombin fragment 1+2 ( F ( 1+2 ) ) , and plasma lipids . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We evaluated each subject ' s hemostatic factors , including factor 7 , factor 12 , thrombin antithrombin 3 complex ( TAT ) , fibrinogen , plasmin antiplasmin complex ( PIC ) , plasminogen activator inhibitor ( PAI 1 ) , and D dimer . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is known to be elevated in the glomeruli of MRL lpr / lpr mice , and intraperitoneal administration of either TGF beta or TNF alpha into normal mice markedly induced the expression of this potent inhibitor of fibrinolysis in renal glomerular or tubular cells in vivo . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Hyperglycemia increased expression from an 85 bp truncated plasminogen activator inhibitor 1 ( PAI 1 ) promoter luciferase reporter containing two Sp 1 sites in a similar fashion ( 3 . 8 fold ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
APC plays an important role in regulating coagulation and fibrinolysis by inactivating not only blood coagulation factors Va and VIIIa but also type 1 plasminogen activator inhibitor ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Here we report the identification of a novel 38 base pair TGF beta responsive element in the human plasminogen activator inhibitor 1 ( PAI 1 ) promoter , which contains two Sp 1 binding sites , and is required for TGF beta induced Smad dependent transcriptional activation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : The following parameters were evaluated in 104 patients with previously untreated hypertension : plasminogen activator inhibitor 1 ( PAI 1 ) , tissue plasminogen activator ( tPA ) antigen , fibrinogen , D dimer , and von Willebrand factor ( vWF ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Since alpha ( s 2 ) casein also binds plasminogen and tissue type plasminogen activator ( t PA ) , resulting in the conversion of plasminogen to plasmin , and since IGFBP 5 binds to plasminogen activator inhibitor 1 ( PAI 1 ) , we investigated whether apoptosis and extracellular matrix ( ECM ) degradation might be coordinately controlled by GH and PRL possibly acting through IGFBP 5 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The antifibrinolytic molecule plasminogen activator inhibitor 1 ( PAI 1 ) is a cardiovascular risk factor that is consistently elevated in insulin resistant states such as obesity and non insulin dependent diabetes mellitus ( NIDDM ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor type 1 ( PAI 1 ) antigen and PAI 1 activity were only decreased in the rilmenidine group ( not statistically significant ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
High plasma levels of plasminogen activator inhibitor 1 ( PAI 1 ) are associated with an increased risk of cardiovascular disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In vivo tumor progression in mice with targeted deficiencies in urokinase type plasminogen activator ( UPA / ) and its inhibitor , plasminogen activator inhibitor 1 ( PAI 1 / ) , was studied using a fibrosarcoma tumor model . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To investigate the prognostic significance of the plasminogen activation system in human chondrosarcoma , the immunohistochemical expression of urokinase type plasminogen activator ( uPA ) , urokinase type plasminogen activator receptor ( uPAR ) , plasminogen activator inhibitor , 1 ( PAI 1 ) and 2 ( PAI 2 ) were analyzed in 28 patients with chondrosarcoma . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : We compared the biological characteristics , that is , growth rate , motility , and invasive activity , of five ovarian cancer cell lines with the gene expression of various matrix proteases ( matrix metalloproteinase 1 [ MMP 1 ] , MMP 2 , MMP 9 , membrane type MMP type 1 [ MT 1 MMP ] , MT 2 MMP , MT 3 MMP , urokinase plasminogen activator [ uPA ] ) , their inhibitors ( tissue inhibitor of metalloproteinase type 1 [ TIMP 1 ] , TIMP 2 , plasminogen activator inhibitor type 1 , [ PAI 1 ] , and PAI 2 ) , and the potential transcriptional regulators E1AF and Ets 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Total cholesterol ( TC ) , high density lipoprotein cholesterol ( HDL C ) , triglycerides ( TG ) , lipoprotein ( a ) ( Lp ( a ) ) , fibrinogen , plasminogen activator type 1 antigen ( PAI 1 ) , tissue plasminogen antigen ( t PA ) , von Willebrand factor ( vWF ) , and plasma total homocysteine ( tHcy ) were measured before and 12 weeks after the start of the study in both groups . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Induction of renal failure by five sixths nephrectomy of Sprague Dawley rats resulted in hypertension ( 163 + / 19 vs . control pressures of 108 + / 6 mmHg ) , proteinuria ( 83 + / 47 vs . 14 + / 2 mg / day ) , and increased renal expression of fibronectin , thrombospondin , collagen 1 and 3 , transforming growth factor beta ( TGF beta ) , and plasminogen activator inhibitor 1 ( PAI 1 ) mRNA . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
However , the role of the individual activators ( urokinase [ uPA ] and tissue plasminogen [ tPA ] activators ) and inhibitors ( plasminogen activator inhibitor [ PAI 1 ] ) of the fibrinolytic system in maintaining patency after coronary artery angioplasty and stenting is unclear . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We assessed plasminogen activator ( uPA and tPA ) and inhibitor ( PAI 1 ) expression in rat iliofemoral arteries after balloon injury using Western blot , enzyme activity , and quantitative reverse transcriptase polymerase chain reaction ( RT PCR ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Chromogenic assays , immunoblotting , and Northern blot hybridization methods were employed to assess the effects of various agonists on the production of tissue plasminogen activator ( t PA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) by the lymphatic endothelium ( LEC ) . ^^^ Fibrin autography showed that plasminogen dependent fibrinolytic activity occurred at M ( r ) of 110 kDa , which represents a complex of tPA with PAI 1 , and 65 and 55 kDa bands corresponding to tPA and uPA , respectively . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This study was designed to investigate the relationship of urokinase type plasminogen activator ( uPA ) , uPA receptor ( uPAR ) , and plasminogen activator inhibitor type 1 ( PAI 1 ) to invasion and metastasis of hepatocellular carcinoma ( HCC ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
When the endothelial cells were injured by thrombin , secretion of plasminogen activator inhibitor 1 ( PAI 1 ) increased and then the PA activity proportionally decreased . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
All patients showed normal antithrombin , protein C , protein S , and plasminogen activator inhibitor 1 ( PAI 1 ) values . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Impaired fibrinolysis as a result of increased plasminogen activator inhibitor 1 ( PAI 1 ) levels in plasma is a common finding in patients with deep vein thrombosis ( DVT ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : Tumor necrosis factor alpha ( TNF alpha ) , interleukin ( IL ) 6 , IL 10 , cICAM 1 , tissue type plasminogen activator ( t PA ) , plasminogen activator inhibitor 1 ( PAI 1 ) , and D dimer antigens were measured by ELISA in the blood of 45 RA patients and 33 healthy subjects ( HS ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma levels of plasminogen activator inhibitor 1 activity ( PAI 1 ) and serum triglycerides were increased by alcohol . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Does plasminogen activator inhibitor 1 ( PAI 1 ) control trophoblast invasion . ^^^ Urokinase plasminogen activator , its receptor and the inhibitor PAI 1 are believed to control proteolysis and remodelling of maternal tissue during trophoblast invasion . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor type 1 ( PAI 1 ) , the most important physiological fibrinolysis inhibitor , is considered an independent factor of cardiovascular risk in Type 2 diabetes mellitus ( T2DM ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The present study underscores a regulatory role of intracellular ceramide in astrocytes for the release of an extracellular serine protease , tissue type plasminogen activator ( t PA ) , and its inhibitor , plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Total cholesterol and tissue plasminogen activator ( t PA ) , plasminogen activator inhibitor 1 ( PAI 1 ) and t PA PAI 1 complex were reduced . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Dissolution of the fibrin blood clot is regulated in large part by plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^ This study found that genetic deficiency for PAI 1 , the primary physiologic regulator of tissue type plasminogen activator ( tPA ) , prolonged the time to occlusive thrombosis following photochemical injury to carotid atherosclerotic plaque in apolipoprotein E deficient ( apoE ( / ) ) mice . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We assayed antiphospholipid antibodies [ lupus anticoagulant ( LA ) and anticardiolipin antibodies ( aCL ) ] , lipoprotein ( a ) [ Lp ( a ) ] , plasminogen activator inhibitor 1 ( PAI 1 ) , and total homocysteine ( tHcy ) levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The enhancement by fucoidan 6 AH or by CNBr Fbg of the in vitro activation of Glu Plg by t PA was reversed by plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
SSeCKS gene expression and plasminogen activator inhibitor 1 ( PAI 1 ) gene expression correlate in RASM cells treated with Ang 2 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We focused on plasminogen activator inhibitor 1 ( PAI 1 ) because it is directly induced by angiotensin , inhibits matrix degradation , and may thus be pivotal in remodeling . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The increased expression of plasminogen activator inhibitor type 1 ( PAI 1 ) is associated with increased concentrations of fatty acids in blood and may accelerate atherogenesis in diabetes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Mice deleted for the plasminogen activator inhibitor 1 ( PAI 1 ) gene are relatively protected from developing pulmonary fibrosis induced by bleomycin . ^^^ We hypothesized that PAI 1 deficiency reduces fibrosis by promoting plasminogen activation and accelerating the clearance of fibrin matrices that accumulate within the damaged lung . ^^^ Although elimination of fibrin from the lung was not in itself protective , the beneficial effect of PAI 1 deficiency was still associated with proteolytic activity of the plasminogen activation system . ^^^ We conclude that protection from fibrosis by PAI 1 deficiency is dependent upon increased proteolytic activity of the plasminogen activation system ; however , complete removal of fibrin is not sufficient to protect the lung . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We investigated immunohistochemically the localization of type 1 plasminogen activator inhibitor ( PAI 1 ) in rat and human brain tissues . ^^^ The present results support a notion that PAI 1 and its target proteases such as plasminogen activators and thrombin are involved in a variety of physiological and pathological processes in brain . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : Thrombin antithrombin complex ( TAT ) , D dimer , fibrinogen and plasminogen activator inhibitor ( PAI 1 ) antigen plasma levels were determined in 40 patients with AMI and in 23 with UA on admission , at 10 days and at three months . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is a unique member of the serpin family , as it spontaneously converts into a latent conformation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the present study , the fibrinolytic parameters tissue type plasminogen activator ( tPA ; antigen and activity ) and plasminogen activator inhibitor type 1 ( PAI 1 ; antigen and activity ) were measured in peritoneal fluid , in peritoneal biopsies and in plasma to establish the time course of changes in fibrinolytic activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Levels of tissue and urokinase plasminogen activator ( t PA and uPA ) , plasminogen activator inhibitor type 1 ( PAI 1 ) and type 2 ( PAI 2 ) mRNA and protein were assessed by quantitative reverse transcriptase polymerase chain reaction ( Q RT PCR ) and ELISA , respectively . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In type 2 diabetes mellitus the activity of the endogenous fibrinolytic system is reduced secondary to increased plasma activity of the plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We examined the levels of tissue plasminogen activator ( t PA ) , plasminogen activator inhibitor type 1 ( PAI 1 ) , and blood coagulation factors 7 and 10 as parameters of coagulofibrinolysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Concentrations of the fibrinolytic components tPA and urokinase plasminogen activator ( uPA ) , tPA activity and plasminogen activator inhibitor type 1 ( PAI 1 ) concentration were measured by enzyme linked immunoabsorbent assay . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Urokinase type plasminogen activator ( uPA ) , its receptor ( uPAR ) , and its inhibitor , plasminogen activator inhibitor type 1 ( PAI 1 ) , are proposed to be prognostic factors in some cancers . ^^^ METHODS : To determine the prognostic value of the urokinase plasminogen activation system , contents of uPA , uPAR , and PAI 1 were measured in extracts of endometrial cancer tissue using ELISAs . uPA , uPAR , and PAI 1 levels were determined in 91 , 54 , and 92 extracts , respectively , and correlated with tumor histology , stage , grade , lymph node involvement , prevalence of metastasis , and recurrence as well as with estrogen ( ER ) , progesterone ( PR ) , epidermal growth factor ( EGFR ) receptor and HER 2 / neu contents . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In 167 patients , undergoing PTCA , Lp ( a ) plasma levels , aCL , euglobulin lysis time ( ELT ) , plasminogen activator inhibitor 1 ( PAI 1 ) activity and tissue type plasminogen activator ( t PA ) plasma levels were evaluated before the procedure . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Acute psychological stress decreases plasma tissue plasminogen activator ( tPA ) and tissue plasminogen activator / plasminogen activator inhibitor 1 ( tPA / PAI 1 ) complexes in cardiac patients . ^^^ Plasminogen activator inhibitor 1 ( PAI 1 ) inhibits t PA expression . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Immunohistochemistry or in situ hybridization was used to examine the expression of aquaporin 2 ( AQP 2 ) , plasminogen activator inhibitor 1 ( PAI 1 ) , and the composition of the ECM in the inner medulla . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To directly assess the physiological impact of an imbalanced fibrinolytic system on both early and late stages of this disease , mice deficient for plasminogen activator inhibitor 1 ( PAI 1 ( / ) ) were used in a model of vascular injury / repair , and the resulting phenotype compared to that of wild type ( WT ) mice . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Among the proteases involved in the tumor invasion process , components of the plasminogen activator system ( plasminogen activator type urokinase uPA , its membrane receptor uPAR and its two inhibitors PAI 1 and PAI 2 ) appear to define high risk patients in primary breast cancer . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
RESULTS : Pre and postmenopausal women with CAD showed significant lower fibrinolytic activity and higher plasminogen activator inhibitor type 1 ( PAI 1 ) levels than their control groups . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To assess the hypofibrinolytic 4G / 4G mutation of the plasminogen activator inhibitor ( PAI 1 ) gene as a possible factor contributing to severe preeclampsia , abruptio placentae , fetal growth restriction , and stillbirth . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Two monoclonal antibody based enzyme linked immunosorbent assays ( ELISAs ) for the quantitation of porcine plasminogen activator inhibitor 1 ( PAI 1 ) antigen and activity in plasma were constructed and validated . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A 5 microg / kg bolus of tissue plasminogen activator ( t PA ) was infused into 11 healthy subjects followed by measurement of t PA activity and antigen , PAI 1 activity and antigen , t PA / PAI 1 complex , plasmin / antiplasmin ( PAP ) complex and D dimer over 4 h . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
DESIGN AND METHODS : Tissue plasminogen activator ( t PA ) , its endothelial inhibitor ( PAI 1 ) , plasmin : antiplasmin complexes ( PAPc ) , modified antithrombin 3 ( ATM ) , D dimer ( D D ) and fibrinogen ( FIB ) were measured in 36 patients with chronic atrial fibrillation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The effect of insulin and insulin like growth factor 1 ( IGF 1 ) on plasminogen activator inhibitor 1 ( PAI 1 ) release from primary cultures of human preadipocytes and adipocytes has been investigated . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
No associations were observed between antibody titres to C . pneumoniae and C reactive protein ( CRP ) , interleukin 6 ( IL 6 ) , age , total cholesterol levels , fibrin degradation products ( FDP ) , plasminogen activator inhibitor 1 ( PAI 1 ) and erythrocyte sedimentation rate ( ESR ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
AIMS : To plasminogen activator system ( PAS ) consists of the plasminogen activators ( urokinase ( uPA ) and tissue type ( tPA ) plasminogen activators ) , the uPA receptor ( uPAR ) , and the plasminogen activator inhibitors ( PAI 1 and PAI 2 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : The concentrations of fibrinogen , factor 7 and 8 , von Willebrand factor , plasminogen activator inhibitor 1 ( PAI 1 ) , and tissue plasminogen activator have been associated with coronary heart disease . ^^^ FINDINGS : Quantitative genetic model fitting showed that genetic factors contributed to about 41 75 % of the variation in concentrations of fibrinogen , factor 7 , factor 8 , PAI 1 , tissue plasminogen activator , factor 13 A subunit and B subunit , and von Willebrand factor . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Several recent studies have shown that stimulation of the RAAS may be associated with an activation of plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A complex of plasminogen activator inhibitor 1 ( PAI 1 ) and PAI 1 binding protein ( PAI 1 BP ) contained S protein ( vitronectin ) , PAI 1 and unidentified 40 kDa protein on SDS PAGE under reducing conditions . ^^^ However , after the incubation of PAI 1 with SP 40 , 40 at 37 degrees C for 1 h , PAI 1 could still form a complex with tissue plasminogen activator ( tPA ) , and it inhibited plasmin formation in the mixture of plasminogen and urine plasminogen activator ( uPA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In these subjects , the following parameters were established : euglobulin lysis time ( ELT ) , the concentration of tissue plasminogen activator antigen ( t PA Ag ) , the concentration of urokinase plasminogen activator antigen ( u PA Ag ) , the activity of plasminogen activator inhibitor type 1 ( PAI 1 ) , the concentration of plasmin antiplasmin complex ( PAP ) and fibrinogen / fibrin degradation products ( FDP ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activators ( t PA and u PA ) and plasminogen activators inhibitors ( PAI 1 and PAI 2 ) in some myeloproliferative syndromes . ^^^ In the study we aimed to evaluate fibrinolysis system in blood plasma of the patients with selected myeloproliferative syndromes on the basis of examinations of plasminogen activators ( tissue t PA and urokinase type u PA ) and type 1 and type 2 plasminogen activator inhibitors ( PAI 1 and PAI 2 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : A common 4G allele of a 4G / 5G polymorphism in the promoter region of the plasminogen activator inhibitor 1 ( PAI 1 ) gene is associated with increased transcription of the PAI 1 protein , which may lead to decreased fibrinolysis . ^^^ PAI 1 may protect against destabilization of the atherosclerotic plaque , or it may inhibit neurotoxicity of tissue plasminogen activator in the brain . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We postulate that low vitamin C levels in winter could be associated raised plasma fibrinogen and plasminogen activator 1 ( PAI 1 ) concentrations and therefore with increased cardiovascular risk . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is the primary physiological inhibitor of plasminogen activation in vivo . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We studied thrombin antithrombin complexes ( TAT ) , prothrombin fragments 1+2 ( F1+2 ) , tissue type plasminogen activator ( tPA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) concentrations in patients with acute middle cerebral artery ischemic stroke due to atherosclerotic large artery disease ( n=50 ) , lone AF ( n=24 ) and cardioembolism ( n=21 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The expression of plasminogen activator inhibitor 1 ( PAI 1 ) gene in human astrocytomas ] . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
During their development from progenitor cells , adipocytes not only express enzymatic activities necessary for the storage of triglycerides , but also achieve the capability to produce a number of endocrine factors such as leptin , tumor necrosis factor alpha ( TNFalpha ) , complement factors , adiponectin / adipoQ , plasminogen activator inhibitor 1 ( PAI 1 ) , angiotensin 2 and others . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is a specific inhibitor of plasminogen activators and may be the principal regulator of plasminogen activation in vivo . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Recent studies showed that catecholamines contribute to the regulation of plasminogen activator inhibitor 1 ( PAI 1 ) expression , at least in endothelial cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To investigate further the role of plasminogen activator inhibitor 1 ( PAI 1 ) in human adipose tissue , the regulation of cytokines , cortisol ( dexamethasone ) as well as estrogen on PAI 1 were determined in human adipose tissue fragments . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
There is also suggestion that plasminogen activation inhibitor type 1 ( PAI 1 ) has an important role in atherogenesis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : The aim of the study was to evaluate the prognostic significance of tumour and serum concentrations of urokinase type plasminogen activator ( uPA ) , its type 1 inhibitor ( PAI 1 ) and cathepsin D ( Cath D ) in patients with squamous cell carcinoma of the head and neck ( SCCHN ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Angiotensin converting enzyme ( ACE ) DD genotype , and plasminogen activator inhibitor ( PAI 1 ) 4G / 4G genotype have been reported to affect PAI 1 activity in control subjects and atherosclerotic patients , but no data are available on the influence of angiotensin 2 type 1 receptor ( AT1R ) A1166C polymorphism on the inhibitor levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This study was designed to investigate whether prolactin ( PRL ) affects coordinated regulation of tissue plasminogen activator ( tPA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) gene expression in rat granulosa cells in vitro . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Similar results were obtained for the alpha ( 1 ) antitrypsin variants with thrombin and for PAI 1 and PAI 2 with their common target tissue plasminogen activator . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Venous blood samples were collected at baseline and at 8 weeks after fluvastatin therapy ( 40 mg / day ) to measure of tissue plasminogen activator ( t PA ) , plasminogen activators inhibitor 1 ( PAI 1 ) , fibrinogen , D dimer and lipid profile . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We investigated intracellular mechanisms involved in the up regulation of plasminogen activator inhibitor 1 ( PAI 1 ) synthesis by human recombinant tumor necrosis factor alpha ( TNF ) during monocyte differentiation of HL 60 cells triggered by the transforming growth factor beta1 / vitamin D ( 3 ) ( TGF / D3 ) mixture . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Acute phase protein alpha 1 acid glycoprotein interacts with plasminogen activator inhibitor type 1 and stabilizes its inhibitory activity . alpha ( 1 ) Acid glycoprotein , one of the major acute phase proteins , was found to interact with plasminogen activator inhibitor type 1 ( PAI 1 ) and to stabilize its inhibitory activity toward plasminogen activators . ^^^ Furthermore , the PAI 1 activity toward urokinase type plasminogen activator and tissue type plasminogen activator was significantly prolonged in the presence of alpha ( 1 ) acid glycoprotein . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Elevated expression of plasminogen activator inhibitor 1 ( PAI 1 ) in tumors is associated with a poor prognosis in many cancers . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
MCs reacted with monoclonal antibodies to tryptase , chymase , and c kit / CD117 and stained positively for tissue type plasminogen activator ( tPA ) and urokinase receptor ( uPAR / CD87 ) but did not express detectable urokinase ( uPA ) or plasminogen activator inhibitors ( PAI 1 , PAI 2 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
PSK also suppressed the expression of urokinase plasminogen activator ( uPA ) and uPA receptor but did not change plasminogen activator inhibitor 1 ( PAI 1 ) expression . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In order to determine a correlation of cell cycle phases with the fibrinolytic system , we investigated the expression of u PA , tissue type plasminogen activator ( t PA ) , and plasminogen activator inhibitor type 1 ( PAI 1 ) in normal and tumor containing prostate extracts and analyzed a possible relationship with flow cytometry determined proliferative activity of the samples . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is an inhibitor of the fibrinolytic system . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor type 1 ( PAI 1 ) is an important regulatory component of fibrinolysis and is elevated in the presence of endothelial dysfunction . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Postprandial triglyceridemia may represent a procoagulant state involving disturbances of both blood coagulation and fibrinolysis , in particular due to elevation of the plasma levels of activated factor 7 ( VIIa ) and plasminogen activator inhibitor ( PAI 1 ) . ^^^ Plasminogen activator inhibitor 1 ( PAI 1 ) is the major physiological inhibitor of the plasminogen activators in the circulation and thereby the principal inhibitor of the fibrinolytic system . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A control group of 200 healthy subjects was also investigated for the presence of factor 5 Leiden ( FVL ) , the 20210A allele of the prothrombin ( PT 20210A ) gene , the thermolabile variant ( 677TT ) of methylenetetrahydrofolate reductase ( MTHFR ) , and the 4G / 4G genotype of the plasminogen activator inhibitor ( PAI 1 ) promoter . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is thought to play a major role in the development of progressive fibrosis via the inhibition of extracellular matrix degradation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Increased expression of plasminogen activator inhibitor 1 ( PAI 1 ) in cancer patients is associated with unfavorable outcome , and the reason for this paradox has been poorly understood . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The plasminogen activator inhibitor type 1 ( PAI 1 ) is a multifaceted proteolytic factor . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the present study , effects of OP 1 on the expression of the plasminogen activator inhibitor 1 ( PAI 1 ) in fetal rat calvaria ( FRC ) cells were examined . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To evaluate the role of plasminogen activator inhibitor 1 ( PAI 1 ) and tissue type plasminogen activator ( t PA ) in children with an estimated risk of vascular occlusion reported to range from 7 % to 16 % , we conducted a prospective study in infants and children with underlying cardiac disease . ^^^ Five of the nine infants showed increased PAI 1 clearly correlated to the 4G / 4G genotype of the plasminogen activator 1 promoter polymorphism along with elevated t PA concentration before the first diagnostic cardiac catheterisation was performed . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The 4G / 5G polymorphism of the plasminogen activator inhibitor type 1 ( PAI 1 ) gene is involved in coronary artery disease ( CAD ) , with the highest risk in 4G / 4G homozygotes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) plays an important role in the processes of peripheral tissue remodeling and fibrinolysis through the regulation of plasminogen activation . ^^^ During the apoptotic processes , plasminogen activator ( PA ) activity in the PAI 1 deficient medium was as low as the control level . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma plasminogen activator inhibitor type 1 ( PAI 1 ) , D dimer and prothrombin fragment F 1 + 2 were also measured . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : Plasma plasminogen activator inhibitor 1 ( PAI 1 ) is thought to contribute to the pathogenesis of atherosclerosis and is a predictor of ischemic heart disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Phosphorylation at serine 15 is required for transcriptional induction of the plasminogen activator inhibitor 1 ( PAI 1 ) gene by the alkylating agent N methyl N ' nitro N nitrosoguanidine . ^^^ Here , we show that the physiological inhibitor of urokinase type plasminogen activator , PAI 1 , is also induced by MNNG in a p 53 dependent fashion , because MNNG induced PAI 1 in p 53 expressing cells but not in p 53 / cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) antigen levels were significantly higher in SAFP compared with SAMP ( 18 . 2 vs . 13 . 3 U / ml , P = 0 . 04 ) even after adjustment for known covariates , but there was no difference in PAI 1 antigen levels between males and females in the control group . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
RESULTS : Diabetic women with CHD ( n = 14 ) had greater insulin resistance , calculated by homeostasis model assessment ( 10 . 2 ( 7 . 0 14 . 8 ) vs . 6 . 5 ( 5 . 5 7 . 7 ) , P = 0 . 010 ) , and higher plasminogen activator inhibitor 1 ( PAI 1 ) levels ( 45 ( 29 69 ) vs . 24 ( 19 32 ) ng / ml , P = 0 . 013 ) , than those without CHD . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Protein C was inversely associated with PAD prevalence ( odds ratio 0 . 33 , 95 % CI 0 . 18 0 . 61 , P=0 . 0004 ) . sTM was inversely associated with plasminogen , but no associations with t PA , PAI 1 , or D dimer were seen . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In all investigated persons activities of alpha 1 proteinase inhibitor ( alpha 1 PI ) , alpha 2 macroglobulin ( alpha 2 M ) , alpha 2 antiplasmin ( alpha 2 AP ) , antithrombin 3 ( ATIII ) and plasminogen activator inhibitor type 1 ( PAI 1 ) were determined . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Compared to N and As lines , S lines also had diminished ability to grow in multi layers and exhibited increased mRNA levels for plasminogen activator inhibitor 1 ( PAI 1 ) , secretory leukocyte protease inhibitor ( SLPI ) , and tissue inhibitor of metalloproteinases ( TIMP ) 2 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Transforming growth factor beta ( TGF beta ) treatment resulted in reduced cell surface plasmin generation and a large increase in plasminogen activator inhibitor type 1 ( PAI 1 ) antigen production in NCI H 292 cells , whereas no conspicuous effects were observed with IL 1 beta and TNF alpha treatment ( regulators in pulmonary epithelial cells ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To study the circulating levels of Thrombomodulin ( TM ) and Plasminogen activator inhibitor type 1 ( PAI 1 ) in women with pregnancy induced hypertension ( PIH ) and normal pregnant women . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Proteolytic enzymes , like urokinase ( uPA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) , are involved in remodelling tissues during invasion and metastasis of tumor cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) levels and gene promoter polymorphisms in subjects with colorectal cancer . ^^^ The high level of plasminogen activator inhibitor 1 ( PAI 1 ) in colorectal cancer predicts poor prognosis for patients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Accumulating evidence suggests that plasma levels of the plasminogen activator inhibitor 1 ( PAI 1 ) may modulate the risk of coronary artery disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : Fibrinolytic activity and the main regulators of endogenous fibrinolytic activity , tissue plasminogen activator , and plasminogen activator inhibitor 1 ( PAI 1 ) were measured in patients treated with and without nimodipine . ^^^ The results also show that increased fibrinolytic activity is seen only in patients treated with nimodipine and that plasminogen activity and PAI 1 returned to baseline levels after treatment with nimodipine had been discontinued . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We verified the regulation of protooncogene cot , XMP , and human enhancer of filamentation 1 ( HEF 1 ) , genes involved in cellular proliferation , as well as metallothionein , plasminogen activator inhibitor ( PAI 1 ) , and HM 74 , genes involved in cellular signaling and regeneration . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Therefore , the expression of the matrix metalloproteinase ( MMP ) 2 and MMP 9 and of the serine protease urokinase type plasminogen activator ( uPA ) and its inhibitor plasminogen activator inhibitor type 1 ( PAI 1 ) in the progression of ovarian cancer was investigated . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
PURPOSE : Recent studies suggest that HER 2 / neu specifically promotes the invasive capacity of tumor cells by up regulating secretion of the proteolytic enzyme , urokinase type plasminogen activator ( uPA ) , or its inhibitor , plasminogen activator inhibitor 1 ( PAI 1 ) , in colon and gastric cancer . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
AIMS : Weak staining for urokinase plasminogen activator ( uPA ) , tissue type plasminogen activator ( tPA ) , or plasminogen activator inhibitor 1 ( PAI 1 ) confined to crescents has been described in a few cases of severe crescentic glomerulonephritis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Immunohistochemical analyses of the healing tissues and an analysis of the periodontal wound healing fluid by ELISA were carried out for the detection of tissue type plasminogen activator ( t PA ) , urokinase type plasminogen activator ( u PA ) , and 2 plasminogen activator inhibitors ( PAI 1 and PAI 2 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Conversely , 5 Ha Ras expression decreased steady state levels of mRNAs from tissue inhibitor of metalloproteinase 1 ( TIMP 1 ) , an inhibitor of MMP 9 ; plasminogen activator inhibitor 1 ( PAI 1 ) , which indirectly activates MMP 9 by increasing plasmin levels ; and collagen 4 , a substrate of MMP 9 and a major component of basement membrane . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma plasminogen activator inhibitor type 1 ( PAI 1 ) increases in diabetes , and this might contribute to decreased fibrinolysis and accelerated atherosclerosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Several antibodies against the serine proteinase domain ( SPD ) were found to have overlapping epitopes composed of variable combinations of Arg 178 , Arg 179 , His 180 , Arg 181 , Tyr 209 , Lys 211 , and Asp 214 in the so called 37 loop and 60 loop , located near the active site and taking part in the binding of uPA to plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^ Besides inhibiting uPA catalysed plasminogen activation , all antibodies to SPD strongly delayed the binding of uPA to PAI 1 , decreasing the second order rate constant 15 to 6500 fold . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Recent evidence also suggests that long term NOS inhibition induces expression of plasminogen activator inhibitor 1 ( PAI 1 ) in vascular tissues and that PAI 1 may contribute to the development of fibrosis after chemical or ionizing injury . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We also studied fibrinolysis parameters : plasminogen , tissue type plasminogen activator ( t PA ) antigen , t PA activity , type 1 plasminogen activator inhibitor ( PAI 1 ) antigen , PAI 1 activity , and the 4G / 5G polymorphism of the promoter region of the PAI 1 gene . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In diabetic patients with microangiopathy significantly higher N acetyl beta glucosaminidase ( NAG ) activities in serum and E selection or ICAM 1 concentrations were found as compared with patients without microangiopathy , whereas plasma concentrations of tissue plasminogen activator ( tPA ) or inhibitor ( PAI 1 ) were comparable with those in the control group . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : A balance between urokinase type plasminogen activator ( uPA ) and its main inhibitor type 1 ( PAI 1 ) appears to be important for cancer invasive behavior . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Aldosterone may promote fibrosis by several mechanisms , including plasminogen activator inhibitor 1 ( PAI 1 ) expression and consequent alterations of vascular ribrinolysis , by stimulation of transforming growth factor beta 1 ( TGF beta 1 ) , and by stimulation of reactive oxygen species ( ROS ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The expression of matrix metalloproteinase 2 ( MMP 2 ) , plasminogen activator inhibitor 1 ( PAI 1 ) and interleukin 1 ( IL 1 alpha ) were upregulated in the highly metastatic subpopulations , while the expression of carcinoembryonic antigen ( CEA ) , caspase 5 , Fas ligand , Prk / FNK , cyclin E , cyclin B 1 , Ki 67 , proliferating cell nuclear antigen ( PCNA ) , Smad 4 , macrophage proinflammatory human chemokine 3 alpha ( MIP 3 alpha ) / LARC , Met and CD 44 were downregulated . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activators of urokinase and tissue types and their inhibitor ( PAI 1 ) in cytosol fraction in thyroid diseases ] . ^^^ Enzyme immunoassay ( ELISA ) was used to estimate the levels of plasminogen activators of urokinase ( uPA ) and tissue ( tPA ) types and one of their inhibitors ( PAI 1 ) in the cytosolic fraction of the thyroid in 129 patients with malignant and benign tumors and various non cancer diseases of the gland . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To evaluate the contribution of an imbalance between coagulation activation and fibinolysis activation and inhibition to morbidity and mortality in sepsis , we determined in medical hospitalized patients at inclusion ( day 0 ) for fever ( temperature above 38 . 0 degrees C axillary or 38 . 3 degrees C rectally ) , and daily thereafter for two days , circulating thrombin antithrombin 3 ( TAT ) complexes , plasmin alpha 2 antiplasmin ( PAP ) complexes ( day 0 only ) , tissue type plasminogen activator ( t PA ) , plasminogen activator inhibitor 1 ( PAI 1 ) and interleukin ( IL ) 6 , the latter as a marker of the inflammatory host response . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma levels of plasminogen activator inhibitor type 1 ( PAI 1 ) , tissue type plasminogen activator ( t PA ) , fibrinogen , thrombin antithrombin ( TAT ) complexes , and prothrombin fragments ( F1 . 2 ) were measured at baseline and after standardized venous occlusion ( VO ) in patients with PPH ( 24 female , 9 male ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Alpha 2 antiplasmin ( alpha 2 AP ) and plasminogen activator inhibitor 1 ( PAI 1 ) are the main physiological inhibitors of the plasminogen / plasmin system in mammalian plasma . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Analysis of the proteolytic plasminogen activator system revealed that endostatin modulates the distribution of soluble and cell surface associated urokinase type plasminogen activator ( uPA ) and plasminogen activator inhibitor , type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is one of important coagulant factors . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Both tissue type and urokinase type plasminogen activators can be efficiently inhibited by plasminogen activator inhibitor 1 ( PAI 1 ) , a protease inhibitor of the serpin family . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To clarify the role of plasminogen activator inhibitor type 1 ( PAI 1 ) in postburn hypercoagulation , we assayed the plasma levels of tissue type plasminogen activator ( t PA ) antigen , total PAI 1 antigen , and total t PA PAI 1 complex in 15 burned patients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Platelet plasminogen activator inhibitor 1 ( PAI 1 ) , a trace alpha granule protein , is a key physiological regulator of fibrinolysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Immunohistochemistry was used to detect microvascular integrity , plasminogen activator inhibitor 1 ( PAI 1 ) and the deposition of fibrin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We demonstrate that adipose tissue expresses a number of acute phase reactants at high levels , including serum amyloid A 3 ( SAA 3 ) , alphal acid glycoprotein , the lipocalin 24p3 as well as plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor type 1 ( PAI 1 ) is bound to vitronectin ( VN ) in plasma and in the extracellular matrix . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
EXPERIMENTAL DESIGN : Antigen levels of urokinase type plasminogen activator , plasminogen activator inhibitor 1 ( PAI 1 ) , Cathepsins B , D , and L were determined using immunochemical assays in primary tumor tissue of 276 patients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator ( PA ) inhibitor 1 ( PAI 1 ) has been recognized as a surrogate marker of endothelial dysfunction in diseases associated with impaired angiogenesis , including atherosclerosis , diabetic vasculopathy , and nephropathy . ^^^ To establish the necessary and sufficient components of the PA system [ PAI 1 , urokinase type PA ( uPA ) , or tissue type PA ( tPA ) , and plasminogen ( Plg ) ] for angiogenesis , we examined angiogenic competence of vascular explant cultures obtained from mice deficient in PAI 1 , tPA , uPA , and Plg . ^^^ In summary , 1 ) PAI 1 by itself is a modest inhibitor of endothelial sprouting , 2 ) tPA and Plg are indispensable for angiogenesis in this model , 3 ) Plg is not the only substrate for PAs , and 4 ) the activity of MMP 9 is undetectable in explant cultures from tPA and Plg knockout mice . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
HYPOTHESIS : This study investigated the influence of the 4G / 5G promotor polymorphism of the plasminogen activator inhibitor type 1 ( PAI 1 ) gene on instent restenosis in smoking and nonsmoking patients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Previously , we showed that ectopic expression of E2F1 repressed the plasminogen activator inhibitor type 1 ( PAI 1 ) promoter in a manner dependent on the presence of DNA binding and transactivation domains of E2F1 but independent of binding to pocket binding proteins , suggesting a novel mechanism for E2F mediated negative gene regulation [ Koziczak , M . , Krek , W . & Nagamine , Y . ( 2000 ) Mol . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The serpin plasminogen activator inhibitor type 1 ( PAI 1 ) plays a regulatory role in various physiological processes ( e . g . fibrinolysis and pericellular proteolysis ) and forms a potential target for therapeutic interventions . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
PAI 1 ( plasminogen activator inhibitor 1 ) binds the urokinase type plasminogen activator ( uPA ) and causes its degradation via its receptor uPAR and low density lipoprotein receptor related protein ( LRP ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Increased expression of plasminogen activator inhibitor type 1 ( PAI 1 ) is now considered as an independent risk factor for cardiovascular disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor type 1 ( PAI 1 ) is known to contribute to thrombus formation and to the development and the clinical course of acute and chronic cardiovascular disease , as well as of other arterial and venous thromboembolic diseases . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Antigen and activity levels of tPA and plasminogen activator inhibitor 1 ( PAI 1 ) in media from BEC infected with AdCMVtPA were analyzed . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Michaelis complex , acylation , and conformational change steps were resolved in the reactions of the serpin , plasminogen activator inhibitor 1 ( PAI 1 ) , with tissue plasminogen activator ( tPA ) and trypsin by comparing the reactions of active and Ser 195 inactivated enzymes with site specific fluorescent labeled PAI 1 derivatives that report these events . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) binds to the somatomedin B ( SMB ) domain of vitronectin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Adipose tissue expresses a variety of genes including tumor necrosis factor alpha and type 1 plasminogen activator inhibitor ( PAI 1 ) ; and these factors , produced by adipocytes , may be associated with the risk of coronary events in obesity . ^^^ In this study , we characterized the production of fibrinolytic factors including tissue type plasminogen activator ( tPA ) , urokinase type PA ( uPA ) , and PAI 1 in the differentiation of preadipocytes , and examined the hormonal regulation of these fibrinolytic factors in mature adipocytes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor type 1 ( PAI 1 ) is a rapid inhibitor of tissue plasminogen activator ( tPA ) in circulation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
However , the clot dissolving efficacy of fibrinolytic agents such as tissue type plasminogen activator ( t PA ) is limited , in vivo , in part by the action of plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Blood samples were analysed for hemoglobin ( HB ) , total platelet count ( TPC ) , C reactive protein ( CRP ) , activated partial thromboplastin time ( APTT ) , prothrombin complex ( PT ) , fibrinogen , interleukin 1 beta ( IL 1 beta ) , tumor necrosis factor alpha ( TNF alpha ) , D dimer , tissue plasminogen activator ( t PA ) , plasminogen activator inhibitor 1 ( PAI 1 ) , prothrombin fragments 1 and 2 ( F 1 + 2 ) , and thrombin antithrombin 3 complex ( TAT ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The study population consisted of 1 , 045 postinfarction patients ( 846 non diabetic , 125 non insulin and 74 insulin requiring diabetics ) with the following blood tests performed 2 months after an index myocardial infarction : lipoprotein ( a ) , apolipoprotein B , apolipoprotein A , cholesterol , HDL cholesterol , triglycerides , insulin , von Willebrand factor ( vWF ) , fibrinogen , factor 7 , D dimer , and plasminogen activator inhibitor ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The aim of this study was to compare the effects of trandolapril and losartan on plasminogen activator inhibitor type 1 ( PAI 1 ) levels and insulin sensitivity in hypertensive postmenopausal women . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Markers of endothelial function chosen were adhesion molecules , which are involved in the early stages of atherosclerosis , and plasminogen activator inhibitor 1 ( PAI 1 ) , which is an independent risk factor for the development of cardiovascular disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To investigate the relationship between the plasminogen activator inhibitor 1 ( PAI 1 ) gene polymorphism and cerebrovascular disease and detect whether it plays an important role in the pathogenesis of cerebrovascular disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
There were no major differences between the groups in serum lipoproteins , nonesterified fatty acids , plasma insulin , blood glucose , or plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The aim of this study was to determine whether proinsulin can increase plasminogen activator inhibitor type 1 expression in intra abdominal adipose tissue in vivo , potentially contributing to the increased PAI 1 seen with insulin resistance . ^^^ CONCLUSION / INTERPRETATION : Hyperproinsulinaemia can contribute to increased expression of plasminogen activator inhibitor type 1 in intra abdominal adipose tissue implicated in increasing PAI 1 activity in blood , impaired fibrinolysis , and accelerated atherogenesis typical of Type 2 diabetes . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The components of the plasminogen activator system were measured , i . e . tissue plasminogen activator ( tPA ) , urokinase plasminogen activator ( uPA ) , plasminogen activator inhibitor 1 ( PAI 1 ) and plasminogen activator inhibitor 2 ( PAI 2 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : Elevated plasma levels of plasminogen activator inhibitor type 1 ( PAI 1 ) are associated with myocardial infarction , atherosclerosis , and restenosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We used primary human vascular smooth muscle cells ( VSMC ) and studied the effects of losartan on angiotensin 2 ( Ang 2 ) mediated ( a ) DNA synthesis , ( b ) secretion of tissue type plasminogen activator ( tPA ) and plasminogen activator inhibitor 1 ( PAI 1 ) , ( c ) secretion of matrix metalloprotease 2 ( MMP 2 ) activity and tissue inhibitors of MMPs ( TIMPs ) , and ( d ) synthesis of glycosaminoglycans . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : Plasminogen activator inhibitor type 1 ( PAI 1 ) exerts antifibrinolytic and profibrotic activities . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor type 1 ( PAI 1 ) , an inhibitor of fibrinolysis and an important and independent cardiovascular risk factor , has been shown to be elevated in obesity and type 2 diabetes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Disclosure of a specific prothrombotic / antifibrinolytic state by determination of plasminogen activator inhibitor type 1 ( PAI 1 ) , tissue type plasminogen activator ( t PA ) , and t PA / PAI 1 complex levels in plasma may help to define patients at high risk of developing acute coronary syndromes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Classically , activated protein C ( APC ) of the protein C / protein S anticoagulant pathway has functioned not only to inactivate the procoagulant factors Va and VIIIa but also to inhibit the activity of plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The paper presents recent data on the role of oncogenes and suppressive genes , receptors of steroidal hormones , secretory protein pS 2 , cathepsin D , urokinase and tissue plasminogen activators and their inhibitor PAI 1 , polypeptide growth factors and somatostatin and their receptors in the evaluation of proliferative activity and drug therapy responses and in the prediction of disease and on the simultaneous estimation of the limited number of mutually complementing parameters that can characterize the proliferative activity of a tumor , its metastatic potential and sensitivity to different types of overall and regional regulation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We investigated the effects of low density lipoproteins ( LDL ) and lipoprotein ( a ) [ Lp ( a ) ] oxidized by O2 * / HO * free radicals generated by gamma radiolysis of water , on the release of tissue Plasminogen Activator ( tPA ) and of its main inhibitor Plaminogen Activator Inhibitor 1 ( PAI 1 ) by human umbilical vein endothelial cells ( HUVEC ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
There is a strong link between inhibition of fibrinolysis and obesity , and elevation of the plasma inhibitor , plasminogen activator inhibitor 1 ( PAI 1 ) , is regarded as a central factor . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
On both treatment days , substance P caused dose dependent increases in blood flow and plasma t PA antigen and activity concentrations ( P < 0 . 001 for all ) but had no effect on plasma plasminogen activator inhibitor type 1 ( PAI 1 ) concentrations . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : In the present study , we investigated , by in situ hybridization , PAR 1 gene expression and the mRNA levels for tissue factor and plasminogen activator inhibitor 1 ( PAI 1 ) , two key regulatory molecules of coagulation and fibrinolysis , in 16 CAN biopsies and in 10 normal human kidney grafts . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The content of urokinase and tissue type plasminogen activators and plasminogen activator inhibitor PAI 1 in the cytosol of primary and metastatic melanomas and benign skin pigment neoplasms was estimated by enzyme immunoassay . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We assessed the potential role of 3 factor 13 subunit A coding sequence polymorphisms , along with a promoter polymorphism of plasminogen activator inhibitor 1 ( PAI 1 , which is also involved in fibrin stabilization and vascular remodeling ) , in young white women with hemorrhagic stroke . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The presence of SCIs was associated with older age , higher levels of 24 h systolic blood pressure , 2 h insulin , thrombin generation markers ( prothrombin fragment 1+2 and thrombin antithrombin complexes ) , plasminogen activator inhibitor 1 ( PAI 1 ) , D dimer and von Willebrand factor ( vWF ) , but not with plasmin alpha 2 plasmin complex ( PIC ) levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) expression by keratinocytes has been identified shortly after wound injury . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To examine whether differences in body fat distribution contribute to this risk , 12 healthy AIs and 12 Caucasians matched for age and body mass index ( BMI ) underwent a 75 g oral glucose tolerance test , 2 h euglycemic hyperinsulinemic clamp , abdominal ( L 2 3 ) computed tomography scan , and fasting lipid and plasminogen activator inhibitor 1 ( PAI 1 ) levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The RAS is now recognized to be linked to induction of plasminogen activator inhibitor 1 ( PAI 1 ) likely via both the type 1 ( AT 1 ) and type 4 ( AT 4 ) receptors , thus , promoting both thrombosis and fibrosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The complex between urokinase type plasminogen activator ( uPA ) and its inhibitor PAI 1 ( plasminogen activator inhibitor 1 ) has been prognostically evaluated in patients with breast cancer . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS AND RESULTS : In 47 PMI patients recently submitted to cardiological assessment and in 42 controls ( 50 70 years old men ) , traditional risk factors ( total cholesterol , high density lipoprotein cholesterol , blood glucose , blood pressure , cigarette smoking and body mass index ) and the following variables were measured : fibrinogen , plasminogen activator inhibitor 1 ( PAI 1 ) , lipoprotein ( a ) [ Lp ( a ) ] , total homocysteine , plasma folates , vitamin B 12 , high sensitivity C reactive protein and C 3 complement . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Expression of urokinase and tissue type plasminogen activators and their inhibitor PAI 1 in the cytosolic fraction of 20 osteosarcomas , 20 chondrosarcomas , 13 giant cell bone tumors , 5 Ewing ' s sarcomas , and 7 osteochondral exostoses was studied by enzyme immunoassay . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This study investigates the extent of plasminogen activator inhibitor 1 ( PAI 1 ) and apolipoprotein ( a ) [ apo ( a ) ] in the plaques of different types of coronary artery disease as well as the correlation between these molecules and infiltration of macrophages to plaques . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The type 1 inhibitor of plasminogen activator ( PAI 1 ) is an important physiological regulator of extracellular matrix ( ECM ) homeostasis and cell motility . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Subcutaneous abdominal , but not femoral fat expression of plasminogen activator inhibitor 1 ( PAI 1 ) is related to plasma PAI 1 levels and insulin resistance and decreases after weight loss . ^^^ AIMS / HYPOTHESIS : Abdominal fat produces plasminogen activator inhibitor 1 ( PAI 1 ) and could contribute to increased plasma PAI 1 values in human obesity associated with insulin resistance . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Concerning the fibrinolytic parameters , both OCs increased plasminogen activity , whereas no changes in PAI 1 , t PA , alpha 2 antiplasmin or fibrin degradation products were observed . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Urokinase plasminogen activator and its inhibitor , PAI 1 , in association with progression free survival in early stage endometrial cancer . ^^^ We investigated the prognostic importance of u PA and plasminogen activator inhibitor type 1 ( PAI 1 ) in endometrial cancer , analysed with luminometric immunoassay ( LIA ) and enzyme linked immunosorbent assay ( ELISA ) , respectively . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the present study we examined the relation of uPA ( urokinase plasminogen activator ) , uPAR ( uPA receptor ) and PAI 1 ( plasminogen activator inhibitor type 1 ) to the biological growth behavior of esophageal cancer , as well as their influence on survival in esophageal cancer . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The concentrations of endothelin 1 ( E ) , von Willebrand factor ( vWF ) , plasminogen activator inhibitor 1 ( PAI 1 ) and thrombomodulin ( T ) were measured in the cell culture media . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
There is abundant evidence that the plasminogen activator ( PA ) system with its key components uPA ( urokinase type plasminogen activator ) , its cell surface receptor uPA R ( CD 87 ) and its inhibitor PAI 1 plays a key role in tumour invasion and metastasis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
There is ample information on the clinical role of biologic factors in female breast cancer : urokinase type plasminogen activator ( uPA ) , its receptor uPAR , its inhibitors PAI 1 and PAI 2 , cathepsin D and pS 2 protein . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma total homocysteine ( tHcy ) rises with urinary albumin excretion rate in diabetes , and plasminogen activator inhibitor 1 ( PAI 1 ) has been correlated with increased matrix accumulation in various glomerulopathies . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This type of loop insertion is unique to plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Using an invasive technique , we studied the mean transit time , the net quantitative turnover rate , and the sites of synthesis and catabolism of tissue plasminogen activator ( t PA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) in healthy young volunteers in the fasting , steady state . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activators ( tissue type ; t PA and urokinase type ; u PA ) and plasminogen activator inhibitors ( PAI 1 , PAI 2 ) are found in high concentrations in gingival crevicular fluid ( GCF ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma levels of tissue plasminogen activator ( t PA ) antigen and activity , crosslinked fibrin degradation products ( D dimer ) , alpha 2 antiplasmin plasmin complex , and plasminogen activator inhibitor 1 ( PAI 1 ) antigen were measured . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Thrombin / antithrombin 3 complex ( TAT ) , soluble fibrin ( SF ) , total fibrinogen and fibrin degradation products ( TDP ) , plasminogen activator inhibitor type 1 ( PAI 1 ) , urokinase type plasminogen activator ( uPA ) and uPA receptor ( uPAR ) were measured preoperatively , starting anesthesia , during surgery and postoperatively . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The thermolabile variant ( TT ) of the methylenetetrahydrofolate reductase ( MTHFR ) gene , and homozygosity for the 4G allele of the promoter region of the plasminogen activator inhibitor 1 ( PAI 1 ) are potential genetic polymorphisms that have not been consistently associated with increased risk of VT . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Elevated cytokines induce tissue factor mediated activation of coagulation , suppression of the anticoagulant pathway , and plasminogen activator inhibitor 1 ( PAI 1 ) mediated inhibition of fibrinolysis followed by disseminated fibrin deposition in the microvasculature . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Convincing evidence indicates that this imbalance between coagulation and fibrinolysis is due to increased levels of plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
AIM : To determine the activity of glutathione ( GSH ) and concentrations of glutathione S transferases ( GST ) , urokinase type plasminogen activator ( uPA ) , and plasminogen activator inhibitor type 1 ( PAI 1 ) , and to evaluate their diagnostic and prognostic value and possible correlation with clinical and histopathological prognostic factors for ovarian carcinomas . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is the primary inhibitor of tPA and uPA activity , and is expressed in corresponding brain areas . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The expression of tissue factor ( TF ) , the primary initiator of hemostasis ; urokinase type plasminogen activator ( uPA ) ; tissue type plasminogen activator ( tPA ) ; plasminogen activator inhibitor 1 ( PAI 1 ) as well as the potent matrix metalloprotease , MMP 3 was assessed . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Type 1 plasminogen activator inhibitor ( PAI 1 ) , the primary inhibitor of tissue type plasminogen activator ( t PA ) , is found in plasma and platelets . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Methods and Results We performed a literature search to identify published case control studies correlating the factor 5 Leiden or prothrombin G20210A mutations or fibrinogen G 455A or plasminogen activator inhibitor 1 ( PAI 1 ) 4G / 5G polymorphisms with the risk of myocardial infarction . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Hemorrhagic skin lesions and thrombosis are caused by up regulation of tissue factor which induces coagulation , and by inhibition of fibrinolysis by plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activation without changes in tPA and PAI 1 in response to subcutaneous administration of ancrod . ^^^ Plasmin generation is independent of an increase in tPA activity or changes in plasminogen activator inhibitor 1 ( PAI 1 ) concentration in plasma . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Because fibrinolytic system components have been demonstrated to play an important role in the balance of intraperitoneal generation and degradation of fibrin , we studied the effect of early and advanced glycated human serum albumin , methylglyoxal , and 3 deoxyglucosone on the synthesis of tissue type plasminogen activator ( tPA ) , as well as its specific inhibitor ( PAI 1 ) , in human peritoneal mesothelial cells ( HPMC ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Components investigated were the fibrinolytic stimulator tissue plasminogen activator ( t PA ) , urokinase plasminogen activator ( uPA ) and the antagonist . plasminogen activator inhibitor type one ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The results were related to disease activity variables and accumulated disease activity , to lipid levels [ i . e . , cholesterol , high density lipoproteins , low density lipoproteins , triglycerides ( TG ) ] , to hemostatic factors [ tissue plasminogen activator antigen ( tPAag ) , plasminogen activator inhibitor 1 ( PAI 1 ) , von Willebrand factor ( vWF ) ] , and to soluble adhesion molecules ( sICAM 1 and sE selectin ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Platelet dependent thrombin generation and plasma concentrations of catecholamines , thrombin antithrombin 3 complex ( TAT ) , plasmin alpha 2 plasmin inhibitor complex ( PIC ) , and plasminogen activator inhibitor 1 ( PAI 1 ) were measured before , immediately after , and at 10 and 30 min after stress . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Higher molecular weight forms ( 97 110 kDa ) of plasminogen activators were seen in zymograms , apparently complexed with PAI 1 , starting at 6 h both in the presence and absence of hydrocortisone . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : In 30 cases of primary prostate carcinoma ( stage A ) , serum levels of testosterone ( T ) , free testosterone ( FT ) , dehydroepiandrosterone ( DHEA ) , sex hormone binding globulin ( SHBG ) , prostatic specific antigen ( PSA ) , triglyceride ( TG ) , total cholesterol ( TC ) , high density lipoprotein cholesterol ( HDL C ) , low density lipoprotein cholesterol ( LDL C ) , apoprotein alpha 1 ( APO alpha 1 ) and apoprotein beta ( APO beta ) , insulin , plasma fibrinopeptide A ( FPA ) , plasminogen activator inhibitor 1 ( PAI 1 ) , fibrinogen were determined before and 1 week , 1 , 4 , 8 months after castration . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Urokinase plasminogen activator receptors ( u PAR ) , u PA and plasminogen activator inhibitor type 1 ( PAI 1 ) were determined by immunoassay and RNase protection assay . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : Increased levels of fibrinogen and plasminogen activator inhibitor 1 ( PAI 1 ) are associated with an increased risk of ischemic coronary disease and its complications . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In our pilot study , we analyzed the clinical relevance of YB 1 expression in breast cancer ( n = 83 ) after a median follow up of 61 months and compared it with tumor biologic factors already used for clinical risk group discrimination , i . e . , HER 2 , urokinase type plasminogen activator ( uPA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
On the other hand , high tumor tissue concentrations of urokinase plasminogen activator ( uPA ) , uPA receptor ( R ) and PAI 1 have more consistently been associated with poor histologic differentiation and poor prognosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To investigate the mechanism of Chinese medicine ligustrazini against thrombosis , and the effects of ligustrazini on plasminogen activator inhibitor ( PAI 1 ) expression in normal endothelial cells and lipopolysaccharide ( LPS ) stimulated endothelial cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To investigate the role of active plasminogen activator inhibitor 1 ( PAI 1 ) in the evolution of a microthrombus generated in the arteriolar microcirculation , the monoclonal antibody , 33H1F7 , which transforms active PAI 1 to a tissue type plasminogen activator ( t PA ) substrate , was evaluated in an arteriolar thrombosis model in the rat mesentery . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is a serine protease inhibitor ( SERPIN ) specific for tissue type and urokinase like plasminogen activators . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
RESULTS : The children in whom the hemolytic uremic syndrome subsequently developed had significantly higher median plasma concentrations of prothrombin fragment 1+2 , tissue plasminogen activator ( t PA ) antigen , t PA plasminogen activator inhibitor type 1 ( PAI 1 ) complex , and D dimer than children with uncomplicated infection . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To investigate the association between gene polymorphism of the plasminogen activator inhibitor 1 ( PAI 1 ) and myocardial infarction ( MI ) in Chinese . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A ground state dimer ( denoted D ( 1 ) ) exhibiting a strong absorption maximum at 477 nm ( epsilon = 97 000 M ( 1 ) cm ( 1 ) ) can form between adjacent BODIPY groups attached to mutant forms of the protein , plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To observe the effect of puerarin on superoxide dismutase ( SOD ) , lipid peroxidation ( LPO ) , tissue plasminogen ( TPA ) and plasminogen activator inhibitor ( PAI 1 ) of coronary heart disease ( CHD ) patients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Interaction of plasminogen activator inhibitor type 1 ( PAI 1 ) with vitronectin . ^^^ The serpin plasminogen activator inhibitor type 1 ( PAI 1 ) plays an important role in physiological processes such as thrombolysis and fibrinolysis , as well as pathophysiological processes such as thrombosis , tumor invasion and metastasis . ^^^ In addition to inhibiting serine proteases , mainly tissue type ( tPA ) and urokinase type ( uPA ) plasminogen activators , PAI 1 interacts with different components of the extracellular matrix , i . e . fibrin , heparin ( Hep ) and vitronectin ( Vn ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The plasminogen activator inhibitor 1 ( PAI 1 ) is stabilized in its inhibitory conformation by binding to Vitronectin ( Vn ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A weak inverse correlation emerged between TGF beta 1 and age ( r= 0 . 28 ) , TGF beta 1 and lipoprotein ( a ) [ Lp ( a ) ; r= 0 . 35 ] , TGF beta 1 and C reactive protein ( CRP ; r= 0 . 27 ) , and TGF beta 1 and plasminogen activator inhibitor 1 ( PAI 1 ; r= 0 . 41 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the present study , we used immunohistochemistry and in situ hybridization techniques to determine the localization of urokinase type ( u PA ) and tissue type ( t PA ) plasminogen activators , type 1 plasminogen activator inhibitor ( PAI 1 ) and membrane receptor for u PA ( uPA R ) antigen and their sites of synthesis in renal thrombotic microangiopathy ( N = 10 ) as compared to acute tubular necrosis ( N = 5 ) and normal human kidneys ( N = 7 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In acute liver injury , HSC derived TGF beta increased plasminogen activator inhibitor type 1 ( PAI 1 ) and alpha 2 ( 1 ) procollagen ( COL1A2 ) transcripts . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Previous studies by our group indicated that nonenzymatically glycated low density lipoprotein ( LDL ) increased plasminogen activator inhibitor 1 ( PAI 1 ) production and decreased the generation of tissue plasminogen activator ( tPA ) from cultured human umbilical vein endothelial cells ( HUVEC ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue type plasminogen activator ( t PA ) and its inhibitor ( PAI 1 ) in plasma and in human peripheral blood monocyte cell ( PBMC ) , as well as the procoagulant activity ( PCA ) in PBMC were measured by chromogenic substrate method . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) and alpha 2 anti plasmin ( alpha 2 AP ) may contribute to arterial thrombolysis resistance . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Pooled analysis of prognostic impact of urokinase type plasminogen activator and its inhibitor PAI 1 in 8377 breast cancer patients . ^^^ BACKGROUND : Urokinase type plasminogen activator ( uPA ) and its inhibitor ( PAI 1 ) play essential roles in tumor invasion and metastasis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is one of the primary inhibitors of the fibrinolytic system and has been implicated in a variety of thrombotic disorders . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This overview summarizes the current knowledge on plasminogen activator inhibitor 1 ( PAI 1 ) in the progression of atherosclerosis and the influence of MMPs in aneurysm formation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BTEB2 / IKLF and Hex activate not only the SMemb gene but also other genes activated in synthetic SMCs including plasminogen activator inhibitor 1 ( PAI 1 ) , iNOS , PDGF A , Egr 1 , and VEGF receptors . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Vitronectin ( Vn ) stabilizes the inhibitory form of plasminogen activator inhibitor 1 ( PAI 1 ) , an important modulator of fibrinolysis . ^^^ The binding of PKA phosphorylated Vn to immobilized PAI 1 and to immobilized plasminogen is shown to be lower than that of Vn . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Serine proteinase inhibitors , including plasminogen activator inhibitor type 1 ( PAI 1 ) and antithrombin , are key regulators of hemostatic processes such as thrombosis and wound healing . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) or heparin , but not desulfated glycosaminoglycans , interfered with binding of VN to TGF beta , and soluble PAI 1 was able to dissociate VN bound TGF beta . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
MEASUREMENTS AND RESULTS : After blood sampling we measured activation markers of fibrinolysis [ plasmin / alpha ( 2 ) antiplasmin complexes ( PAP ) , complexes of tissue plasminogen activator / plasminogen activator inhibitor ( tPA / PAI ) , fibrin ( ogen ) degradation products ( FDPs ) , D dimmers fibrin degradation products ( D d ) ] , the utilization marker of antithrombin 3 ( ATIII ) thrombin / antithrombin complexes ( TAT ) , several factors of fibrinolysis [ plasminogen , tissue plasminogen activator ( tPA ) , plasminogen activator inhibitor 1 ( PAI 1 ) , alpha ( 2 ) antiplasmin ] , and the natural coagulation inhibitors [ ATIII , protein C ( PrC ) , protein S ( PrS ) ] . ^^^ In severe sepsis and mainly in septic shock , coagulation inhibitors ( ATIII , PrC ) and plasminogen were markedly decreased , whereas tPA and PAI 1 were further increased . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The potential importance of the renin angiotensin system in glomerular sclerosis is underscored by the effectiveness of therapies that aim to inhibit its manifold actions , including induction of plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To investigate the effects of inflammatory cytokines on the production of plasminogen activator inhibitor 1 ( PAI 1 ) by human pleural mesothelial cells ( HPMC ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To observe the influence of plasminogen activator inhibitor 1 ( PAI 1 ) overexpression on extracellular matrix ( ECM ) accumulation of rat mesangial cells . ^^^ The recombinant PAI 1 / GFP had significant inhibition activity on urokinase type plasminogen activator and displayed autonomous fluorescence . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Prothrombin time ( PT ) , partial thromboplastin time ( PTT ) , fibrinogen ( FBG ) , platelets ( PLT ) , thrombin antithrombin complexes ( TAT ) , t PA Ag , t PA activity , plasminogen activator inhibitor 1 ( PAI 1 ) , and alpha 2 antiplasmin ( AP ) activities were measured . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Antibodies to both uPA and uPA receptor ( uPAR ) were shown to significantly inhibit cell invasion , as did the uPA inhibitors ( plasminogen activator inhibitor 1 [ PAI 1 ] , p aminobenzamidine [ PABN ] , aprotinin , and amiloride ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : This study compares the effect of estrogens and ACE inhibition on plasminogen activator inhibitor 1 ( PAI 1 ) concentrations in healthy postmenopausal women , genotyped for a 4G / 5G polymorphism in the PAI 1 promoter , a polymorphism shown to influence PAI 1 concentrations . ^^^ Methods and Results Morning estradiol , PAI 1 , tissue plasminogen activator , plasma renin activity , angiotensin 2 , and aldosterone were measured in 19 postmenopausal women ( 5G / 5G : 4G / 5G : 4G4G=5 : 10 : 4 , respectively ) at baseline and during randomized , single blind , crossover treatment with conjugated equine estrogens 0 . 625 mg per os per day , ramipril 10 mg per os per day , and combination estrogens and ramipril . ^^^ Both conjugated estrogens [ PAI 1 antigen from 12 . 5 ( 7 . 6 , 17 . 4 ) [ mean ( 95 % CI ) ] baseline to 6 . 6 ( 2 . 6 , 10 . 7 ) ng / mL , P < 0 . 01 ] and ACE inhibition [ 8 . 3 ( 4 . 9 , 11 . 7 ) ng / mL , P < 0 . 005 ] decreased PAI 1 without decreasing tissue plasminogen activator . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
High levels of components of the plasminogen activation system , and paradoxically also its inhibitor , plasminogen activator inhibitor 1 ( PAI 1 ) , have been correlated with a poor prognosis for patients with cancers of different types . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
As increased plasminogen activator inhibitor type 1 ( PAI 1 ) activity ( act ) is an early marker of cardiovascular risk in PCOS , we have sought abnormalities in young girls with PP . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Levels or presence of protein C , protein S , antithrombin , methylenetetrahydrofolate reductase C677T , factor 5 Leiden , prothrombin gene G20210A , antiphospholipid antibodies , plasminogen , tissue type plasminogen activator ( tPA ) , type 1 tPA inhibitor ( PAI 1 ) , PAI 1 4G / 5G polymorphism , prothrombin fragment 1+2 , plasmin / alpha ( 2 ) antiplasmin complexes , thrombomodulin , and activated factors 7 and 12 were determined . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have examined expression of the components of the plasminogen activation system in human astrocytoma U 373 MG cells and found that interleukin 1beta ( IL 1beta ) , tumour necrosis factor alpha TNF alpha ) , interferon gamma ( INF gamma ) and epidermal growth factor ( EGF ) specifically regulate the expression of tissue type plasminogen activator ( t PA ) , urokinase type plasminogen activator ( u PA ) , plasminogen activator inhibitor type 1 ( PAI 1 ) and protease nexin 1 ( PN 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We conducted a randomized controlled trial to assess the effects of these drugs on plasminogen activator inhibitor 1 ( PAI 1 ) antigen , an inhibitor of fibrinolysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To evaluate the association between haemostatic parameters and increased risk of myocardial infarction ( MI ) at a young age , we measured fibrinogen , factor 7 , antithrombin 3 , protein C , protein S , tissue factor ( TF ) , free form tissue factor pathway inhibitor ( TFPI ) , plasminogen , alpha 2 antiplasmin , tissue plasminogen activator ( tPA ) , plasminogen activator inhibitor 1 ( PAI 1 ) , and lipoprotein ( a ) in 140 young men with MI before age 45 and 150 age matched healthy men . ^^^ TF , TF / TFPI ratio , PAI 1 , PAI I / tPA ratio , plasminogen , and lipoprotein ( a ) in young MI patients were all significantly higher than controls , while TFPI , antithrombin 2 , and tPA were significantly lower ( P < 0 . 001 of each ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Human atherosclerotic lesions exhibit increased expression of plasminogen activator inhibitor type 1 ( PAI 1 ) that has been implicated in atherogenesis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the plasmin dependent pathway , the expression of plasminogen activator inhibitor ( PAI 1 ) mRNA was continuously increased , while the expression of urokinase type plasminogen activator ( uPA ) mRNA was not increased . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is believed to control proteolytic activity and cell migration during angiogenesis . ^^^ We also showed that PAI 1 angiogenic activity is associated with its control of plasminogen activation but not with the regulation of cell matrix interaction . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : Polycystic ovarian syndrome ( PCOS ) is associated with insulin induced plasminogen activator inhibitor 1 ( PAI 1 ) elevations . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue plasminogen activator ( t PA ) and tissue plasminogen activator inhibitor ( PAI 1 ) activities were measured . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) inhibits this process . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Inhibitor of plasminogen activator 1 ( PAI 1 ) in hepatocellular carcinoma ] . ^^^ OBJECTIVE : To study the expression of the type 1 inhibitor of plasminogen activator ( PAI 1 ) on protein and mRNA in hepatocellular carcinoma ( HCC ) , and the relation between PAI 1 and biological behaviour of HCC . ^^^ When negative PAI 1 conupared with positive urokinase type plasminogen activator ( uPA ) and positive uPA receptor ( uPAR ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To study the relationship between plasminogen activator inhibitor type 1 ( PAI 1 ) and biological behaviour of hepatocellular carcinoma ( HCC ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To describe abnormalities in coagulation and fibrinolysis in septic shock with purpura and to assess the relationship between plasma plasminogen activator inhibitor 1 ( PAI 1 ) concentrations and multiple organ system failure ( MOSF ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is the primary inhibitor of both tissue and urokinase type plasminogen activators ( t PA , u PA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma tissue plasminogen activator ( t PA ) , plasminogen activator inhibitor 1 ( PAI 1 ) , fibrinogen , and D dimer were measured before and 20 minutes after the procedures . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We examined the alteration of plasminogen activator inhibitor 1 ( PAI 1 ) and tissue type plasminogen activator ( t PA ) in kidneys with unilateral ureteral obstruction in rats . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To investigate the change of plasminogen activator inhibitor 1 ( PAI 1 ) synthesized by the iris and the lens epithelial cells ( LECs ) after extracapsular cataract extraction ( ECCE ) with intraocular lens ( IOL ) implantation and the role of PAI 1 in the occurrence of fibrin reaction and the formation of posterior capsular opacification . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The present study tests the hypothesis that endogenous aldosterone regulates plasminogen activator inhibitor 1 ( PAI 1 ) production in humans . ^^^ Hemodynamic parameters , PAI 1 and tissue type plasminogen activator ( t PA ) antigen , potassium , PRA , angiotensin 2 , and aldosterone were measured in nine male hypertensive subjects after a 3 wk washout , after 2 wk of hydrochlorothiazide ( HCTZ ; 25 mg plus 20 mmol KCl / d ) , and after 2 wk of spironolactone ( 100 mg / d plus KCl placebo ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To explore the relationship of plasminogen activator inhibitor 1 ( PAI 1 ) gene 675 4G / 5G and beta fibrinogen gene 455 G / A variations to glomerular microthrombosis ( T ) in lupus nephritis ( LN ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Such signaling processes are stimulated by protease activated receptor 1 ( PAR 1 ) , which upon activation , causes the expression of various substances including tissue factor ( TF ) and plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^ Statins downregulate TF mitigating thrombin generation and also downregulate PAI 1 , which normally consumes tissue plasminogen activator ( tPA ) . ^^^ In the absence of PAI 1 , tPA activates plasminogen to generate plasmin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Furthermore , MMP 3 specifically hydrolyzes and inactivates human plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
PURPOSE : A strong prognostic impact of urokinase type plasminogen activator ( uPA ) and its inhibitor and plasminogen activator inhibitor type 1 ( PAI 1 ) as individual factors is well established in breast cancer . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The plasminogen activator system , including plasminogen activator inhibitor type 1 ( PAI 1 ) , plays a key role in tumor invasion and neoangiogenesis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Concentration of : tissue plasminogen activator antigen ( t PA : Ag ) , urokinase plasminogen activator antigen ( u PA : Ag ) , plasminogen activator inhibitor type 1 antigen ( PAI 1 : Ag ) ( ELISA ) , PAI 1 activity ( PAI 1 act . ) , euglobulin lysis time ( ELT ) ( Kowarzyk Buluk method ) , fibrinogen , fibrin degradation products ( FDP ) ( Merskey method ) in blood plasma were evaluated . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : Subjects with an ultrasound confirmed deep venous thrombosis had prothrombin fragment 1+2 ( F 1+2 ) , tissue plasminogen activator ( t PA ) activity , plasminogen activator inhibitor ( PAI 1 ) activity , and t PA antigen levels determined before anticoagulation therapy . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Enhanced PAI 1 levels from early second trimester and during labour and plasminogen activators in normal pregnancy . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
STUDY OBJECTIVE : Cytokines increase endothelial tissue factor ( TF ) and tissue plasminogen activator inhibitor type 1 ( PAI 1 ) expression in vitro . ^^^ Tissue factor interacts with factor 7 to facilitate thrombosis and PAI 1 inhibits fibrinolysis by endogenous plasminogen activators . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
AIMS : To study long term effects of enalapril on mass concentrations of tissue plasminogen activator ( tPA ) , plasminogen activator inhibitor ( PAI 1 ) , tPA / PAI 1 complex and von Willebrand factor ( vWF ) in both genders with uncomplicated myocardial infarction . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To study the plasminogen activator inhibitors 1 ( PAI 1 ) and matrix metalloproteinases ( MMPs ) expression on the cultured rat mesangial cells ( MsC ) transfected with antisense TGF beta 1 vector . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The aim of the study was to test the effect of natural ( RRR ) AT supplementation ( 1 , 200 IU / day ) on markers of thrombosis , plasminogen activator inhibitor 1 ( PAI 1 ) , and soluble P selectin ( sP selectin ) in type 2 diabetic patients with and without macrovascular complications ( MVCs ) compared with matched control subjects . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) plays a key role in control of coagulation and tissue remodeling and has been shown to be regulated by a number of cell stimuli , among those hypoxia . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The overall normal vessel architecture and the antigenicity of von Willebrand factor , tPA and plasminogen activator inhibitor type 1 ( PAI 1 ) were retained for at least 9 days . tPA was constantly secreted into the conditioned medium at least up to day 12 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Epidemiological studies suggest that elevated plasma levels of plasminogen activator inhibitor 1 ( PAI 1 ) predispose an individual to ischemic heart disease or promote plaque progression by inhibiting fibrinolysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To examine the role of plasminogen activator inhibitor type 1 ( PAI 1 ) , the major fibrinolytic inhibitor , in vivo during murine antigen induced arthritis ( AIA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
PAI 1 concentration was markedly higher in DH patients ( 36 . 2 ng / ml ) than in controls ( 22 . 40 ng / ml ) , whereas plasminogen level was significantly lower ( 86 . 0 % vs . 115 . 9 % ) . ^^^ Increased type 1 plasminogen activator inhibitor level ( PAI 1 ) may reflect a chronic inflammatory condition present in DH patients . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
By use of cultured rat aortic endothelial cells transfected with an IkappaB super repressor ( DeltaN 2 cells ) , we provide evidence that NF kappaB signalling is required in the linoleic acid induced VCAM 1 expression in endothelial cells , whereas other transcription factors appear to be involved in the increased endothelial plasminogen activator inhibitor 1 ( PAI 1 ) production in response to linoleic acid . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Insulin inhibits the pro inflammatory transcription factor early growth response gene 1 ( Egr ) 1 expression in mononuclear cells ( MNC ) and reduces plasma tissue factor ( TF ) and plasminogen activator inhibitor 1 ( PAI 1 ) concentrations . ^^^ We have now tested the effect of insulin on the pro inflammatory transcription factor , early growth response 1 ( Egr 1 ) and plasma concentration of tissue factor ( TF ) and plasminogen activator inhibitor 1 ( PAI 1 ) , two major proteins whose expression is modulated by Egr 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We were able to facilitate plasminogen activator inhibitor 1 ( PAI 1 ) promoter activity approximately by 14 fold using an enhancer element . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Analysis of plasminogen activator inhibitor 1 ( PAI 1 ) expression showed that PAI 1 antigen is upregulated by 24 hr and could account for the tPA activity downregulation seen at this time point . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The purpose of this study was to compare the 30 day prognostic value of the indexes of inflammation [ interleukin 6 ( IL 6 ) ] , endothelial activation [ von Willebrand factor antigen ( vWf ) ] , fibrinolysis [ plasminogen activator inhibitor 1 ( PAI 1 ) ] and coagulation ( F 1 + 2 ) , in a consecutive series of patients with non ST elevation acute coronary syndromes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) has been proposed to play an inhibitory role in arterial neointima formation after injury . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) increases in endotoxin induced DIC and many thrombotic diseases such as myocardial infarction , type 2 diabetes mellitus , and hyperlipidemia . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) polymorphisms in patients with obstructive sleep apnoea . ^^^ Type 1 plasminogen activator inhibitor ( PAI 1 ) is one of the primary regulators of the fibrinolytic system . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have synthesized and evaluated a series of tetramic acid based and hydroxyquinolinone based inhibitors of plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) inhibits plasminogen activators ( u PA and t PA ) by forming stable complexes endocytosed via a low density lipoprotein receptor superfamily member dependent mechanism . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The following variables were measured before treatment as well as after 1 , 3 and 6 months of treatment : factor 7 activity , protein C activity , fibrinogen level , antithrombin 3 activity , plasminogen activator inhibitor 1 ( PAI 1 ) level and the plasma concentration of tissue type plasminogen activator ( t PA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The correlation between insulin and of proinsulin like molecules and those plasminogen activator inhibitor 1 ( PAI 1 ) antigen was also similar ( r = 0 . 28 0 . 29 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We studied the concentrations of C reactive protein ( CRP ) , fibrinogen , and plasminogen activator inhibitor 1 ( PAI 1 ) in 1 , 047 nondiabetic subjects in relation to incident diabetes within 5 years in the Insulin Resistance Atherosclerosis Study . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue plasminogen activator ( tPA ) and urokinase ( uPA ) are targets of plasminogen activator inhibitor 1 ( PAI 1 ) inhibition . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is an important regulator of fibrinolysis by its inhibition of both tissue type and urokinase plasminogen activators . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor type 1 ( PAI 1 ) and tissue plasminogen activator ( tPA ) are the major regulators of plasmin generation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In nonpregnant women s DD showed a good correlation with fibrinolytic parameters [ euglobulin lysis time ( ELT ) and type 1 inhibitor of tissue plasminogen activator ( PAI 1 ) act : P < . 01 ; tissue plasminogen activator ( t PA ) ag and PAI 1 ag : P < . 05 ] , confirming previous data , whereas in pregnant women no correlation was observed . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
TGFbeta was the only growth factor able to exceptionally up regulate plasminogen activator inhibitor 1 ( PAI 1 ) , mainly in dystrophic satellite cells . ^^^ Since TGFbeta challenged dystrophic myoblasts undergo an exceptional up regulation of the receptor and of PAI 1 , we propose the possibility that the TGFbeta induced fibrinolytic pattern ( low urokinase plasminogen activator , high receptor and high PAI 1 ) may be exploited to promote survival and spreading of transplanted engineered myoblasts in Duchenne muscular dystrophy . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The serine proteinase inhibitor plasminogen activator inhibitor type 1 ( PAI 1 ) is the primary physiological inhibitor of the tissue type and the urokinase type plasminogen activator ( tPA and uPA , respectively ) and as such an important regulator of proteolytic events taking place in the circulation and in the extracellular matrix . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Studies on the plasminogen activating system in gingival crevicular fluid ( GCF ) as well as gingival tissue are reviewed . t PA , u PA , PAI 1 and PAI 2 have all been detected in GCF . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Its antiinvasive action is due to an upregulation of tissue inhibitor of matrix metalloprotease 1 ( TIMP 1 ) and plasminogen activator inhibitor ( PAI 1 ) and a downregulation of urokinase type plasminogen activator ( uPA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Relationship of plasma activities of tissue type plasminogen activator ( tPA ) and plasminogen activator inhibitor 1 ( PAI 1 ) with age , sex , body weight , smoking , blood lipids were studied in 131 healthy subjects . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Serum tissue type plasminogen activator ( tPA ) , plasminogen activator inhibitor type 1 ( PAI 1 ) , menstrual and reproductive hormone patterns , lipid and glucose metabolic parameters , bilateral ovarian volume , side effects were determined before and after oral administration of metformin 375 mg three times daily for 12 16 weeks . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Clinical implications of urokinase and tissue type plasminogen activators and their inhibitor ( PAI 1 ) in breast cancer tissue . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Angiotensin 2 ( Ang 2 ) is a potent stimulator of plasminogen activator inhibitor 1 ( PAI 1 ) expression , which is an important regulator of pathogenesis of atherosclerosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Virus induced suppression of hemangiosarcoma was dependent on host T cells and associated with intratumoral persistence of IFN gamma expressing cytotoxic lymphocytes , and led to the reduced expression of hepatic plasminogen activator inhibitor 1 ( PAI 1 ) , a metastasis linked marker . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The components of the PPS include the urokinase plasminogen activator ( uPA ) , its cell surface receptor urokinase plasminogen activator receptor ( uPAR ) , and its naturally occurring inhibitors , plasminogen activator inhibitors 1 and 2 ( PAI 1 and PAI 2 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Other factors in patients with type 2 diabetes include alterations in serum fibrinogen , PAI 1 , tissue type plasminogen activator ( tPa ) and factors 5 , 2 and 7 , which have all been linked to the risk of myocardial infarction . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have used two fluorescent probes , NBD and dansyl , attached site specifically to the serpin plasminogen activator inhibitor 1 ( PAI 1 ) to address the question of whether a common mechanism of proteinase translocation and full insertion of the reactive center loop is used by PAI 1 when it forms covalent SDS stable complexes with four arginine specific proteinases , which differ markedly in size and domain composition . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Angiotensin 2 ( Ang 2 ) is the primary candidate to mediate this inter relationship , since this peptide is capable of stimulating plasminogen activator inhibitor 1 ( PAI 1 ) in vitro and in vivo . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Invasion and metastasis of solid tumors require tumor biologic factors that promote the dissolution of the surrounding tumor matrix and the basement membranes , and the serine protease urokinase type plasminogen activator ( uPA ) and its inhibitor , plasminogen activator inhibitor type 1 ( PAI 1 ) , play major roles in these invasive processes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Polymorphism 4G / 5G in the plasminogen activator inhibitor 1 ( PAI 1 ) gene is associated with IgE mediated allergic diseases and asthma in the Czech population . ^^^ BACKGROUND : Plasminogen activator inhibitor type 1 ( PAI 1 ) is a glycoprotein that belongs to the serine protease inhibitor superfamily and has an essential role in tissue remodeling after inflammation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
There is evidence that type 1 plasminogen activator inhibitor ( PAI 1 ) may have an important role in peritoneal function . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We evaluated the two key components of the fibrinolytic system , tissue type plasminogen activator ( t PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) in women with clinical signs of unstable coronary artery disease ( CAD ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have determined that angiotensin 2 ( Ang 2 ) stimulates plasminogen activator inhibitor 1 ( PAI 1 ) synthesis and secretion in human trophoblasts in a time and concentration dependent manner . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The plasma levels of von Willebrand factor , tissue plasminogen activator ( TPA ) , plasminogen activator inhibitor ( PAI 1 ) , and the TPA PAI 1 complex were significantly increased in TTP / HUS patients ; however , the levels of these markers were not significantly different between TTP / HUS patients who survived and those who died , suggesting that these markers might not be directly related to outcome . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue inhibitors of MMPs ( TIMPs ) and plasminogen activator inhibitor ( PAI 1 ) are produced in conjunction with these enzymes and are important regulators of their activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We chose urokinase type plasminogen activator ( uPA ) , plasminogen activator inhibitor type 1 ( PAI 1 ) and Cathepsin D as invasive markers , and Ki 67 and C erbB 2 oncoproteins as proliferative factors for our study . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The NH ( 2 ) terminal somatomedin B ( SMB ) domain ( residues 1 44 ) of human vitronectin contains eight Cys residues organized into four disulfide bonds and is required for the binding of type 1 plasminogen activator inhibitor ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
There is increasing evidence that angiotensin 2 influences thrombogenesis by regulating the expression of plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^ In this study , the effects of angiotensin 2 and its receptors on the expression and release of PAI 1 and tissue type plasminogen activator ( t PA ) were examined in human coronary artery endothelial cells ( HCAECs ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Hemostatic factors of endothelial origin , i . e . , plasminogen activator inhibitor 1 ( PAI 1 mass ) , von Willebrand Factor ( vWF ) , and D dimer were analyzed by ELISA , and tissue plasminogen activator ( tPA ) activity was analyzed by a chromogen method . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Paradoxically , high levels of plasminogen activator inhibitor 1 ( PAI 1 ) , an endogenous inhibitor of uPA , also predict for aggressive disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma antigen levels of tumor necrosis factor ( TNF ) alpha and interleukin ( IL ) 6 , representative atherogenic cytokines , tissue factor ( TF ) and tissue factor pathway inhibitor ( TFPI ) , markers of coagulation , and plasma activity level of plasminogen activator inhibitor type 1 ( PAI 1 ) , a marker of defective fibrinolysis , were measured . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : a single base pair deletion / insertion ( 4G / 5G ) polymorphism in the plasminogen activator inhibitor ( PAI 1 ) promoter appears to influence PAI 1 synthesis ( increased PAI 1 and inhibition of fibrinolysis with the 4G allele ) and survival after severe trauma . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We also investigated the possible contributions of plasminogen activator inhibitor 1 ( PAI 1 ) , which has been implicated in thrombosis and sclerosis , and the novel steroid receptor superfamily member , peroxisome proliferator activated receptorgamma ( PPARgamma ) , implicated in monocyte foamy macrophage transformation in atherosclerosis and improved insulin responsiveness in diabetes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Prothrombin time ( PT ) , activated partial thromboplastin time ( aPTT ) , fibrinogen , factors 5 , 7 , 8 , 9 and 10 activities , vWF , antithrombin 3 ( AT 3 ) , protein C , protein S , tissue plasminogen activator ( t PA ) and tissue plasminogen activator inhibitor 1 ( PAI 1 ) , as well as common lipid variables , were measured . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fasting blood samples were collected before and after 12 month treatment for determinations of fibrinogen , prothrombin fragment 1+2 ( F1+2 ) , plasma D dimer , soluble tissue factor , tissue plasminogen activator ( tPA ) antigen , tPA activity , plasminogen activator inhibitor type 1 activity ( PAI 1 activity ) and serum D dimer as a global test of fibrinolytic activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To investigate the structural determinants of maspin in its apoptosis sensitizing effect , MDA MB 435 cells were also transfected with maspin / PAI 1 and PAI 1 / maspin chimeric constructs resulting from swapping the N terminal and the C terminal domains between maspin and PAI 1 ( plasminogen activator inhibitor type 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue plasminogen activator ( t PA ) antigen , t PA activity , plasminogen activator inhibitor 1 ( PAI 1 ) activity and plasma renin activity ( PRA ) were measured at the end of a 2 week run in period on the control diet and after each treatment period . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
AIM : Analysis of relationships between clinical characteristics of the patients , high concentration of acute phase proteins fibrinogen , C reactive protein ( CRP ) , activity of the inhibitor of type 1 plasminogen activator ( PAI 1 ) and frequency of angina recurrence after successful coronary angioplasty ( CA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is a potential target for anti thrombotic and anti cancer therapy . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We previously demonstrated that plasminogen activator inhibitor 1 deficient ( PAI 1 / ) mice are protected against hypertension and perivascular fibrosis induced by relatively short term NOS inhibition . ^^^ In this study , we compared the temporal changes in systolic blood pressure and coronary perivascular fibrosis induced by long term treatment with N ( omega ) nitro L arginine methyl ester ( L NAME ) in wild type ( WT ) , PAI 1 ( / ) and tissue type plasminogen activator deficient ( t PA / ) mice . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Circulating concentrations of adipocytokines , such as leptin , tumor necrosis factor alpha ( TNF alpha ) , and plasminogen activator inhibitor 1 ( PAI 1 ) , vary with exercise training , menopause , or regional variations in adipose tissues . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Endothelial dysfunction appears on one hand as suppression in the release of the above mediators , and on the other as deleterious discharge of prostaglandin endoperoxides ( PGH 2 , PGG 2 ) , superoxide anion O 2 , peroxynitrite ( ONOO ) , and plasminogen activator inhibitor ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Primary Breast Cancer , Urokinase Type Plasminogen Activator , Inhibitors The aim of the study was to monitor urokinase plasminogen activator antigen concentrations and its type 1 ( PAI 1 ) and type 2 ( PAI 2 ) inhibitors in histologically defined forms of primary breast cancer and a comparison with these antigens levels in normal tissue . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We investigated the consequences of the gene polymorphisms of tissue plasminogen activator ( tPA ) and plasminogen activator inhibitor 1 ( PAI 1 ) in patients positive for aPL . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) , tissue plasminogen activator activity and plasmin antiplasmin complexes ( PAP ) were detected at baseline and after venous occlusion test . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the serpin plasminogen activator inhibitor 1 ( PAI 1 ) , RCL movements are regulated by vitronectin , having a previously poorly defined binding site lateral to PAI 1 ' s beta sheet A . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We examined the roles of vitronectin and plasminogen activator inhibitor 1 ( PAI 1 ) in neointima development . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Since anti invasive effects of TGF beta in the normal EVT cells were shown to be mediated in part by plasminogen activator inhibitor 1 ( PAI 1 ) and urokinase type plasminogen activator ( uPA ) , we compared the expression of PAI 1 and uPA in the normal EVT , JAR , and JAR smad3 / c cells in the presence or absence of TGF beta 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Gene expression levels for the platelet derived growth factor receptor alpha ( PDGFRalpha ) , plasminogen activator inhibitor 1 ( PAI 1 ) , and stromal cell derived factor 1A ( SDF1A ) are constitutively augmented in RSF compared with NSF . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
DESIGN AND METHODS : Lipids , lipoproteins , lipid hydroperoxide , AuAb oxLDL , total antioxidant status ( TAS ) , serum soluble intercellular adhesion molecule 1 ( sICAM 1 ) , plasminogen activator inhibitor 1 ( PAI 1 ) levels in serum , the activities of antioxidant enzymes including glutathione peroxidase ( GSH Px ) , glutathione reductase ( GR ) , superoxide dismutase ( SOD ) , and catalase ( CAT ) in erythrocytes and plasma , were determined in 25 patients with Behet ' s disease and in 25 healthy volunteers . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma Lp ( a ) concentration and activation of tissue type plasminogen activator ( t PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) were determined in 50 patients with chronic renal failure ( CRF ) and in 50 healthy subjects . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A mutant of TSV PA ( F193G ) , in which Phe ( 193 ) had been replaced by a glycine , was inactivated by plasminogen activator inhibitor 1 ( PAI 1 ) and alpha ( 2 ) antiplasmin 100 fold more rapidly than the wild type enzyme . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The adhesive glycoprotein vitronectin ( VN ) forms a function stabilizing complex with plasminogen activator inhibitor 1 ( PAI 1 ) , the major fibrinolysis inhibitor in both plasma and vessel wall connective tissue . ^^^ PAI 1 complex interaction , resulting in a significant reduction of PAI 1 inhibitory function on plasminogen activators , resembling the effect of VN antibodies that prevent stabilization of PAI 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In addition , serum levels of plasminogen activator inhibitor 1 ( PAI 1 ) , thrombomodulin ( TM ) , tissue plasminogen activator ( tPA ) , and tissue factor ( TF ) were determined . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is one of the target genes of hypoxia inducible factor 1alpha ( HIF 1alpha ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Enzyme linked immunosorbent assays ( ELISAs ) were used to measure cysteine cathepsin B ( CatB ) and cathepsin L ( CatL ) and their inhibitors , stefin A ( StA ) and stefin B ( StB ) , together with urokinase ( u PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) , in 150 cytosols of primary invasive breast carcinoma . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor type 1 ( PAI 1 ) is considered to be the main regulator of fibrinolytic activity in blood and has been identified as a key enzyme in the metastasis and vascularization of solid tumors . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This study revealed OSM mediated expression of mRNAs encoding tissue type plasminogen activator ( tPA ) and plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Resting plasma von Willebrand factor antigen ( vWF Ag ) and tissue plasminogen activator ( tPA ) antigen concentrations and plasminogen activator inhibitor 1 ( PAI 1 ) activity were higher in the patients compared with control subjects . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The endothelium is a major source of plasminogen activator inhibitor 1 ( PAI 1 ) , which plays a critical role in the regulation of fibrinolysis . ^^^ Ang 2 increased PAI 1 and tissue plasminogen activator ( t PA ) release , while its metabolite angiotensin ( 1 7 ) ( Ang ( 1 7 ) ) amino acid fragment decreased them . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have recently shown that resting human mast cells ( MCs ) produce tissue type plasminogen activator ( t PA ) without simultaneously expressing plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is the primary physiological inhibitor of plasminogen activation in blood . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Northern blot analysis demonstrated that genes encoding urokinase type plasminogen activator ( uPA ) , urokinase type plasminogen activator receptor ( uPAR ) , plasminogen activator inhibitor 1 ( PAI 1 ) , tissue inhibitor of metalloproteinases ( TIMP 1 ) and c myc were up regulated in response to hyaluronan . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
INTRODUCTION : Plasminogen activator inhibitor 1 ( PAI 1 ) , a known inhibitor of plasminogen activators , may regulate smooth muscle cell migration ( SMC ) through alteration in matrix metalloproteinase ( MMP ) activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Physiologic and histologic changes were studied in addition to TGF beta 1 , plasminogen activator inhibitor 1 ( PAI 1 ) and biglycan mRNA expressions by Northern blot . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Using the microsequencing method we identified the third one , a M ( r ) 45 , 000 glycosylated protein , as plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
These results were confirmed when additional control for fibrinogen and plasminogen activator inhibitor type 1 ( PAI 1 ) was carried out in a subgroup of cases and controls . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We previously demonstrated in glomerular mesangial and endothelial cells that both high glucose concentrations and glucosamine activated the plasminogen activator inhibitor 1 ( PAI 1 ) gene promoter through the transcription factor , Sp 1 ; and that the glutamine : fructose 6 phosphate amidotransferase inhibitor , 6 diazo 5 oxonorleucine , inhibited the effect of high glucose , but not that of glucosamine . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : Thirteen age and gender matched sibling pairs of Type 2 ( non insulin dependent ) diabetic patients , one hyperglycaemic , one normoglycaemic ( fasting plasma glucose at screening 6 . 0 7 . 7 mmol . l ( 1 ) and < 6 . 0 mmol . l ( 1 ) , respectively ) were assessed for plasminogen activator inhibitor antigen ( PAI 1 ) , tissue plasminogen activator antigen ( t PA ) , fibrinogen , Factor 7 and Factor VIII / von Willebrand factor antigen . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is a serine protease inhibitor that was isolated 20 years ago . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The present study was aimed at characterization of TCDD to induce plasminogen activator inhibitor 1 ( PAI 1 ) in mouse hepatoma cell lines . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We therefore investigated the prognostic value of plasminogen activator inhibitors type 1 ( PAI 1 ) and type 2 ( PAI 2 ) and the combination of both inhibitors in 332 patients with operable breast cancer . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Leptin , placenta growth factor , the plasminogen activator inhibitor ( PAI 1 ) / PAI 2 ratio , and uric acid were predictive of the development of preeclampsia . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Concurrent increases in the levels of thrombomodulin , tissue factor , and plasminogen activator inhibitor type 1 ( PAI 1 ) indicated increased production of these proteins . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
One receptor for the ApoE protein is the LRP / alpha 2 macroglobulin receptor , which also binds to and endocytoses tPA and plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Transcription of c fos , collagenase , transforming growth factor beta , actin , urokinase plasminogen activator and its type 1 inhibitor ( PAI 1 ) appears to be particularly responsive to shape activated signaling pathways . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Thrombus formation and degradation is partly due to a complex interplay between tissue type plasminogen activator ( t PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^ The goal of this study was to conduct an exploratory data analysis to determine whether there is evidence that the relationship ( i . e . correlation ) between plasma t PA and PAI 1 is influenced by interactive effects of the angiotensin converting enzyme ( ACE ) insertion / deletion ( I / D ) and plasminogen activator inhibitor 1 ( PAI 1 ) 4G / 5G polymorphisms in a sample of 50 unrelated African Americans and 117 unrelated Caucasians . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The goal of this study was to compare CPM with linear regression analysis for the exploratory analysis of non additive interactive effects of the angiotensin converting enzyme ( ACE ) insertion / deletion ( I / D ) and plasminogen activator inhibitor 1 ( PAI 1 ) 4G / 5G polymorphisms on plasma PAI 1 levels in a sample of 50 unrelated African Americans and 117 unrelated Caucasians . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Urokinase type plasminogen activator ( uPA ) , its inhibitors ( PAI 1 and PAI 2 ) , and its receptor ( uPAR ) play a key role in tumor invasion and metastasis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We measured tissue plasminogen activator ( tPA ) antigen , plasminogen activator inhibitor 1 ( PAI 1 ) and fibrinogen levels in South Indian diabetic and non diabetic subjects with and without CAD . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
TCDD induced the early appearance of ovarian plasminogen activator inhibitor type 1 ( PAI 1 ) , plasminogen activator inhibitor type 2 ( PAI 2 ) , urokinase plasminogen activator ( uPA ) , and tissue plasminogen activator ( tPA ) at 24h after dosing when compared with controls . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : Plasminogen activator inhibitor 1 ( PAI 1 ) regulates fibrinolysis and has been reported to be an independent risk factor for ischemic cardiovascular events . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fasting blood was taken for plasma glucose , insulin , lipids , IGF 1 , plasminogen activating inhibitor 1 ( PAI 1 ) and the adhesion molecules ICAM 1 , VCAM 1 and E Selectin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Also , the level of gene expression of transforming growth factor beta ( TGF beta ) and plasminogen activator inhibitor 1 ( PAI 1 ) in the renal cortex were reduced , suggesting that lisinopril improved extracellular matrix ( ECM ) metabolism . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We investigated relationships among adult periodontitis , smoking , and a variation in the deletion / insertion ( 4G / 5G ) promoter polymorphism of the plasminogen activator inhibitor 1 ( PAI 1 ) gene in 304 Caucasian subjects . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Urokinase plasminogen activator and its inhibitor , PAI 1 , as prognostic markers in breast cancer : from pilot to level 1 evidence studies . ^^^ Paradoxically , high concentrations of plasminogen activator inhibitor ( PAI 1 ) , an endogenous inhibitor of uPA , also correlate with poor prognosis in patients with breast cancer , including the subgroup with node negative disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : Quantitative real time reverse transcription PCR ( RT PCR ) assays were developed to quantify urokinase type plasminogen activator ( uPA ) , plasminogen activator inhibitor type 1 ( PAI 1 ) , and tissue metalloproteinase inhibitor type 1 ( TIMP 1 ) mRNA in 54 breast cancer tissues . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
One hundred and six subjects with peripheral arterial disease ( PAD ) and intermittent claudication were characterized on the activity level of tissue plasminogen activator ( tPA , the activator of fibrinolysis ) , the activity level of plasminogen activator inhibitor ( PAI 1 , the inhibitor of fibrinolysis ) , daily physical activity , ambulatory function , and demographic information . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
RESEARCH DESIGN AND METHODS : Von Willebrand factor ( vWF ) , tissue plasminogen activator ( t PA ) , plasminogen activator inhibitor type 1 ( PAI 1 ) , and thrombomodulin were studied as markers of endothelial dysfunction in a population based study of elderly subjects with normal glucose tolerance ( NGT ) or IGT and type 2 diabetes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The observation , that increased plasma plasminogen activator inhibitor 1 ( PAI 1 ) levels were associated with insulin resistance and atherothrombosis added for the first time a pathological basis for an association of the insulin resistance syndrome not only with metabolic , atheromatous ( atherosclerotic ) risk but also with atherothrombotic risk . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) , the primary physiological inhibitor of both tissue type plasminogen activator and urokinase type plasminogen activator in plasma , is a well established risk factor in thrombotic diseases . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The expression of the cardiac ECM proteins , plasminogen activator inhibitor 1 ( PAI 1 ) , fibronectin , and collagen type 1 , was examined by Western blotting using extracts from neonatal rat primary cardiac fibroblasts . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : Although the renin angiotensin system and insulin resistance ( IR ) have been identified as major regulators of plasminogen activator inhibitor type 1 ( PAI 1 ) , their roles in hypertensive subjects is not clearly defined . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
MATERIALS AND METHODS : The effects of BK on the expression of tissue factor ( TF ) , tissue factor pathway inhibitor ( TFPI ) , plasminogen activator inhibitor 1 ( PAI 1 ) , and tissue type plasminogen activator ( TPA ) in cultured rat aortic endothelial cells ( RAECs ) were respectively evaluated by Northern blot and chromogenic assay or enzyme linked immunosorbent assay ( ELISA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BRCA 2 co activates Smad 3 dependent transcriptional activation of luciferase reporter and expression of plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The relative distribution of type 1 fibres and capillarization were positively related to high density lipoprotein ( HDL ) cholesterol and negatively to serum triglycerides ( TG ) and plasminogen activator inhibitor 1 ( PAI 1 ) activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The plasminogen activator system , including urokinase type plasminogen activator ( uPA ) and type 1 plasminogen activator inhibitor ( PAI 1 ) , plays an important role in repair of the peritoneum damaged by several types of peritonitis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A 2 week infusion of AII ( 300 ng / kg / min ) via an osmotic pump increased systolic blood pressure ( 171 + / 2 vs . 138 + / 6 mm Hg ) , urinary protein excretion ( 32 + / 6 vs . 14 + / 2 mg / day ) , and renal ( 2 . 2 + / 0 . 5 vs . 1 . 0 + / 0 . 1 ) and cardiac ( 1 . 8 + / 0 . 3 vs . 1 . 0 + / 0 . 1 ) gene expression of plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) , an inhibitor of urokinase plasminogen activator , is paradoxically associated with a poor prognosis in breast cancer . ^^^ Furthermore , stable transfection of a related serine protease inhibitor , plasminogen activator inhibitor 3 ( PAI 3 , or protein C inhibitor ) gave results similar to wild type PAI 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : The aim of our study was to examine whether plasminogen activator inhibitor 1 ( PAI 1 ) plasma levels varied as a function of differences in glucose tolerance status independently of body fatness , body fat distribution , and insulin sensitivity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The strong prognostic impact of the two invasion factors urokinase type plasminogen activator ( uPA ) and its inhibitor , plasminogen activator inhibitor type 1 ( PAI 1 ) , in breast cancer has recently been validated at level 1 evidence . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : Data about the effects of smoking on thrombo hemostatic factors ( tissue factor [ TF ] and tissue factor pathway inhibitor [ TFPI 1 ] ) are limited and on fibrinolytic factors ( tissue plasminogen activator [ t PA ] and plasminogen activator inhibitor 1 [ PAI 1 ] ) are debatable . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To investigate the relationship of circulating plasminogen activator inhibitor 1 ( PAI 1 ) levels with features of insulin resistance and genotype at a single nucleotide insertion / deletion ( 4G / 5G ) polymorphism in the promoter region of the PAI 1 gene in 101 South Asian ischaemic stroke patients and 102 symptom free reference subjects . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The plasmatic levels of the following haemostatic factors were measured within the first 6 h of the SIRS evolution : von Willebrand Factor ( vWF ) , thrombomodulin , plasminogen activity inhibitor type 1 ( PAI 1 antigen ) , tissue type plasminogen activator ( t PA antigen ) , prothrombin fragment 1 + 2 ( F 1 + 2 ) , thrombin antithrombin complexes ( TAT ) and D dimer . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have previously cloned epithelioid type smooth muscle cells from rat carotid arteries , and showed that polypeptide growth factors basic fibroblast growth factor ( bFGF ) and platelet derived growth factor ( PDGF ) could dose dependently induce plasminogen activator inhibitor 1 ( PAI 1 ) secretion from these cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We found that mLRP1B4 and urokinase plasminogen activator receptor ( uPAR ) form immunoprecipitable complexes on the cell surface in the presence of complexes of uPA and its inhibitor , plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The serpin plasminogen activator inhibitor 1 ( PAI 1 ) is a well known risk factor for thromboembolic and cardiovascular diseases . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma plasminogen activator inhibitor 1 ( PAI 1 ) levels were higher in mice on the HFD as compared to the SFD ; they were comparable in extracts of s . c . or GON adipose tissue , whereas at different time points tissue type ( t PA ) and urokinase type ( u PA ) plasminogen activator activity was somewhat lower in the adipose tissues of mice on HFD . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Invasion factors urokinase type plasminogen activator ( uPA ) and its plasminogen activator inhibitor ( PAI 1 ) are the only novel tumor biological prognostic factors validated at the highest level of evidence with regard to their clinical utility in breast cancer . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The neutralization of positively charged Arg residues in this cluster decreases the affinity of scu PA and the double chain urokinase type plasminogen activator for PAI 1 , which results in an enhancement of the stability in plasma and the fibrinolytic efficiency of the activator . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fibronectin ( FN ) and plasminogen activator inhibitor type 1 ( PAI 1 ) synthesis were measured by ELISA . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Multiple logistic regression models showed that plasminogen activator inhibitor 1 ( PAI 1 ) antigen ( P = 0 . 029 ) , percentage change of body weight ( P = 0 . 001 ) and bilirubin ( P < 0 . 001 ) were independent marker variables for the occurrence of VOD , and PAI 1 antigen ( P = 0 . 030 ) and bilirubin ( P = 0 . 049 ) were independent marker variables for the occurrence of severe VOD . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In addition to aspartyl and cysteineproteinases , serine proteinases including the plasminogen activator system ( uPA , uPAR , tPA , PAI 1 and PAI 2 ) and matrix metalloproteinases ( MMPs ) with their tissue inhibitors ( TIMPs ) play an essential role in these processes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is a key factor of fibrinolytic activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : The prognostic value of plasma concentrations of tissue type plasminogen activator ( t PA ) , plasminogen activator inhibitor 1 ( PAI 1 ) , and C reactive protein has been reported in patients with coronary artery disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Its major components are urokinase ( uPA ) and tissue type plasminogen activator ( tPA ) , plasminogen activation inhibitor type 1 and 2 ( PAI 1 and PAI 2 ) and a receptor for urokinase ( uPAR ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : The serum concentrations of fasting glucose , insulin , lipids , the activities of tissue type plasminogen activator ( t PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) , and the level of blood pressure were measured in 159 patients with stroke and 40 healthy control subjects . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Effect of thrombin on cell proliferation and plasminogen activator inhibitor type ( PAI 1 ) expression in human embryonic glomerular mesangial cells ] . ^^^ OBJECTIVE : To explore the effect of thrombin on cell proliferation and plasminogen activator inhibitor Type 1 ( PAI 1 ) expression in human embryonic glomerular mesangial cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To assess the effects of pharmacological interruption of the renin angiotensin system on the fibrinolysis , tissue plasminogen activator antigen ( t PA ) , plasminogen activator inhibitor 1 antigens ( PAI 1 ) and neurohormones , such as plasma renin activity , norepinephrine , angiotensin 2 ( AII ) and 4 ( AIV ) concentrations , were measured in 60 hypertensives . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue plasminogen activator ( t PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) have opposing effects on thrombi . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) , tissue plasminogen activator ( t PA ) , fibrinogen and insulin were measured in 43 patients 3 years after they had undergone the Magenstrasse and Mill ( MM ) procedure and in 43 morbidly obese ( MO ) patients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the present study , we describe an assay for the assessment of components of the plasminogen activation system ( uPA , tPA and PAI 1 , and their complexes ) in blood which is not susceptible to interference by heterophilic antibodies . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Significance of urokinase type plasminogen activator and plasminogen activator inhibitor 1 ( PAI 1 ) expression in human colorectal carcinomas . ^^^ In the present study , the antigen levels of urokinase type plasminogen activator ( uPA ) and its inhibitor PAI 1 , and their immunohistochemical staining were compared in paired colorectal tumor ( n = 64 ) and background colon tissue of the same patients with clinical and pathological staging . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Mural thrombus of the aorta in association with homozygous plasminogen activator inhibitor type 1 ( PAI 1 ) 675 ( 4G ) and heterozygous GP Ia 807C / T genotypes . ^^^ The genetic analysis showed a homozygous mutation of plasminogen activator inhibitor type 1 ( PAI 1 ) 675 ( 4G ) and a heterozygous mutation of GP Ia 807C / T . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Measures included fibrinogen , plasminogen activator inhibitor 1 ( PAI 1 ) , D dimer , C reactive protein ( CRP ) , fitness , percent body fat ( % BF ) , and visceral adiposity ( VAT ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Low levels of tPA or excessive levels of plasminogen activator inhibitor 1 ( PAI 1 ) cause hypofibrinolysis , causally related to the development of atherosclerosis and associated thrombotic complications , as well as with the development of venous and arterial thrombosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have delineated two different reaction mechanisms of monoclonal antibodies ( mAbs ) , MA 8H9D4 and either MA 55F4C12 or MA 33H1F7 , that convert plasminogen activator inhibitor 1 ( PAI 1 ) to a substrate for tissue ( tPA ) and urokinase plasminogen activators . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This review explores the hypothesis that the RAAS causes injury and fibrosis , in part , through effects on plasminogen activator inhibitor 1 ( PAI 1 ) , the major physiologic inhibitor of plasminogen activators in vivo . ^^^ PAI 1 , by inhibiting the production of plasmin from plasminogen , tips the balance in favor of extracellular matrix accumulation and promotes fibrosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Interestingly , this distribution pattern coincided with what we have recently described for the plasminogen activator inhibitor 2 ( PAI 2 ) mRNA , however differing from that of the plasminogen activator inhibitor 1 ( PAI 1 ) mRNA , as also shown here . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Statins reduced mRNA levels of plasminogen activator inhibitor 1 ( PAI 1 ) and increased the mRNA levels of thrombomodulin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : Plasminogen activator inhibitor type 1 ( PAI 1 ) is the primary physiologic inhibitor of plasminogen activator in vivo . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Expression of mRNA for the plasminogen activators ( uPA and tPA ) and their inhibitor ( PAI 1 ) were analyzed by RT PCR ELISA . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Transcription of the gene encoding plasminogen activator inhibitor type 1 ( PAI 1 ) , a serine protease inhibitor important in the control of barrier proteolysis and cell to matrix adhesion , is spatially temporally regulated following epithelial denudation injury in vitro as well as in vivo . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Of 14 screened coagulation parameters , thromboxane B ( 2 ) ( TXB ( 2 ) ) , prostaglandin F ( 1alpha ) ( PGF ( 1alpha ) ) , plasminogen activator inhibitor type 1 ( PAI 1 ) , thrombomodulin ( TM ) , and thrombospondin ( TSP ) were found to be ultrasound sensitive . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : The fibrinolytic activities of conditioned medium and cell lysates from human glioma cell lines , A 172 , T98G , U 87 and TM 1 were studied by fibrin plate zymography . mRNA expression of tissue plasminogen activator ( tPA ) , urokinase type plasminogen activator ( uPA ) and plasminogen activator inhibitors ( PAI 1 , PAI 2 ) was measured by Northern blot analysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We assessed lipids , body mass index ( BMI ) and new risk factors : lipoprotein ( a ) Lp ( a ) , apolipoprotein A 1 ( apo A 1 ) and apolipoprotein B ( apo B ) , homocysteine ( Hcy ) , fibrinogen ( FB ) , tissue plasminogen activator ( t PA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor type 1 ( PAI 1 ) , a risk marker of atherosclerosis , is highly expressed in adipose tissue from obese subjects . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Replacement of the four tryptophans of plasminogen activator inhibitor type 1 ( PAI 1 ) with the spectrally unique analogue 7 azatryptophan permitted observations of conformational changes in the serpin but not those of the proteinase . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : Both thrombolytic therapy and coronary angioplasty have been inconsistent together for primary acute myocardial infarction ( AMI ) therapy , because conventional thrombolytic agents accelerate plasminogen activator inhibitor 1 ( PAI 1 ) activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Serum levels of tissue type plasminogen activator ( tPA ) activity , plasminogen activator inhibitor 1 ( PAI 1 ) activity , tPA antigen , PAI 1 antigen , FVII , FX , and fibrinogen were assayed after both treatments . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The plasminogen activator inhibitor 1 ( PAI 1 ) dependent fibrinolytic inhibition occurring in endotoxemia contributes to disseminated intravascular coagulation ( DIC ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To assess whether the plasminogen activator inhibitor 1 ( PAI 1 ) gene 4G / 5G polymorphism is associated with coronary heart disease ( CHD ) in Chinese patients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Activities and concentrations of tissue plasminogen activator ( tPA ) , plasminogen activator inhibitor type 1 ( PAI 1 ) , tPA / PAI complex , fibrinogen , and D dimers were determined in all specimen with ELISA tests . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
After release of obstruction by removing an encased rubber tube , changes in interstitial volume were morphologically evaluated and the mRNA expression of transforming growth factor beta ( TGF beta ) , type 4 collagen ( collagen 4 ) , and plasminogen activator inhibitor 1 ( PAI 1 ) were examined by reverse transcription polymerase chain reaction ( RT PCR ) up to 28 days . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
RESULTS : Analysis in patients with active PTB showed anemia , leucocytosis , thrombocytosis , elevation in plasma fibrinogen , factor 8 , plasminogen activator inhibitor 1 ( PAI 1 ) with depressed antithrombin 3 ( AT 3 ) and protein C ( PC ) levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
By expressing the fibrinolytic enzyme tissue type plasminogen activator ( t PA ) and its specific inhibitor , plasminogen activator inhibitor 1 ( PAI 1 ) , human peritoneal mesothelial cells ( HMC ) play an important role in regulating peritoneal fibrinolysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In 78 non diabetic , normotensive first degree relatives of type 2 diabetic patients ( 47 without a family history of hypertension and 31 with a family history of hypertension ) and in 36 normoglycemic , normotensive subjects with no family history of hypertension , we evaluated plasma levels of fasting glucose and insulin , tissue type plasminogen activator ( t PA ) , plasminogen activator inhibitor ( PAI 1 ) , D dimer ( DD ) and prothrombin fragment 1 + 2 ( F1+2 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) deficient transgenic mice have improved survival and less fibrosis after intratracheal bleomycin instillation . ^^^ We hypothesize that PAI 1 deficiency limits scarring through unopposed plasminogen activation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have made deletions of the porcine plasminogen activator inhibitor 1 ( PAI 1 ) gene to obtain recombinant truncated PAI 1 proteins to examine functions of the PAI 1 isoforms . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : Sixteen DM2HD patients and 23 healthy individuals ( HI ) had their euglobulin clot lysis time ( ECLT ) , and tissue type plasminogen activator ( tPA ) and plasminogen activator inhibitor 1 ( PAI 1 ) activities ( act ) and concentrations ( ag ) assessed before and after standard fibrinolytic stimulus ( i . v . administration of 0 . 4 microg / kg BW 1 deamino 8 D arginine vasopressin , DDAVP ) along with metabolic status markers . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This behavior suggests that maspin inhibits matrix degrading proteases , such as those of the plasminogen activation system , in a similar manner to the serpin PAI 1 . ^^^ We have compared the effects of maspin with those of PAI 1 in a range of situations in which plasminogen activation is potentiated , reflecting the biological context of this proteolytic system : urokinase type plasminogen activator bound to its receptor on the surface of tumor cells , tissue type plasminogen activator specifically bound to vascular smooth muscle cells , fibrin , and the prion protein . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : Factor VIIc , antithrombin , fibrinogen , thrombin antithrombin complex ( TAT ) , FDP ( D Dimer ) , tissue plasminogen activator ( tPA ) and plasminogen activator inhibitor 1 ( PAI 1 ) were measured in 80 healthy postmenopausal women after 3 , 6 and 12 months therapy with either 17beta oestradiol / norethisterone acetate or tibolone . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We used electron microscopy and immunoconfocal ( IF ) labeling for bFGF , matrix metalloproteinase ( MMP ) 2 , MMP 9 , tissue type plasminogen activator ( tPA ) , its inhibitor ( PAI 1 ) , fibronectin ( FN ) , and Ki 67 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue concentrations of tissue type plasminogen activator ( tPA ) , plasminogen activator inhibitor type 1 ( PAI 1 ) and the resulting tPA activity were assayed . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Here , we show that oncostatin M ( OSM ) and interleukin 1 ( IL 1 ) regulate the expression of plasminogen activator inhibitor 1 ( PAI 1 ) and urokinase type plasminogen activator ( uPA ) in human astrocytes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Decreases in mean creatinine and plasminogen activator inhibitor 1 ( PAI 1 ) levels during DF therapy predicted better survival . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The expression of the plasminogen activator inhibitor 1 ( PAI 1 ) gene is enhanced by insulin both in vivo and in various cell types . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : It has been proposed that the mechanism of action of the new risk factors for myocardial infarction and stroke , von Willebrand factor ( vWF ) , tissue plasminogen activator ( tPA ) and tissue plasminogen activator inhibitor 1 ( PAI 1 ) could possibly be mediated via a primary effect on atherogenesis but there is little data to substantiate this . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : This study was performed to delineate the relationship between plasminogen activator inhibitor type 1 ( PAI 1 ) activity and PAI 1 protein to characterize the functional importance of elevated PAI 1 in diabetes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
AIMS : The potential role of portal over flow on early expression of early growth response gene 1 ( Egr 1 ) , type 1 plasminogen activator inhibitor ( PAI 1 ) and phosphatase of regenerating liver 1 ( PRL 1 ) was analysed by a comparative experimental study using PBL and PH . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In our study , we have studied the effects of CD 44 stimulation by ligation with HA upon the expression of matrix metalloproteinases ( MMPs ) 2 and 9 as well as urokinase type plasminogen activator ( uPA ) , its receptor ( uPAR ) and its inhibitor ( PAI 1 ) and the subsequent induction of invasion of human chondrosarcoma cell line HCS 2 / 8 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Increased level of plasminogen activator inhibitor 1 ( PAI 1 ) and procoagulant activity have been recognized as hallmarks of endothelial dysfunction . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Among coagulative parameters , plasminogen activator inhibitor 1 ( PAI 1 ) was significantly reduced by CEE ( 29 % , P < . 05 ) but not ETP treatment ( +16 % , P = not significant ) , while fibrinogen , antithrombin , and homocysteine were unaffected by therapy . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tumor tissues from 71 patients with CRC were assayed to determine the antigen levels of urokinase type plasminogen activator ( uPA ) , uPA receptor ( uPAR ) , and plasminogen activator inhibitor 1 and 2 ( PAI 1 and PAI 2 ) , as well as immunohistochemical expression of VEGF . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor type 1 ( PAI 1 ) antigen concentrations follow a circadian oscillation peaking in the morning . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We investigated the effects of high concentrations of glucose on plasminogen activator inhibitor 1 ( PAI 1 ) gene expression in cultured rat vascular smooth muscle cells ( VSMC ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Serum levels of testosterone ( T ) , free testosterone ( FT ) , dehydroepiandrosterone ( DHEA ) , sex hormone binding globulin ( SHBG ) , prostatic specific antigen ( PSA ) , triglyceride ( TG ) , total cholesterol ( TC ) , high density lipoprotein cholesterol ( HDL C ) , low density lipoprotein cholesterol ( LDL C ) , apoprotein alpha ( 1 ) ( APOalpha ( 1 ) ) and apoprotein beta ( APObeta ) , insulin , plasma fibrinopeptide A ( FPA ) , plasminogen activator inhibitor 1 ( PAI 1 ) and fibrinogen were determined just prior to , 1 week and 1 , 4 and 8 months after castration . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We adapted template directed dye terminator incorporation with fluorescence polarization detection ( TDI FP ) to the analysis of eight SNPs implicated in mediating the sepsis syndrome : TNF alpha ( 308 ) , TNF alpha ( 238 ) , TNF beta ( +250 ) , IL 1beta ( +3953 ) , IL 6 ( 174 ) , IL 10 ( 592 ) , plasminogen activator inhibitor 1 ( PAI 1 ( 675 ) ) , and TLR 4 299 ( +1032 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is the major inhibitor of endogenous thrombolysis , thereby promoting thrombosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Since elevated plasminogen activator inhibitor 1 ( PAI 1 ) primarily contributes to endotoxin induced thrombosis , we first compared the induction of PAI 1 by lipopolysaccharide ( LPS ) between young and aged mice . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Primary human embryo lung fibroblasts and adult diploid fibroblasts infected by the human cytomegalovirus ( HCMV ) display beta galactosidase ( beta Gal ) activity at neutral pH ( senescence associated beta Gal [ SA beta Gal ] activity ) and overexpression of the plasminogen activator inhibitor type 1 ( PAI 1 ) gene , two widely recognized markers of the process designated premature cell senescence . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
MEASUREMENTS AND RESULTS : Procalcitonin ( PCT ) , C reactive protein ( CRP ) , cytokines ( IL 6 , IL 8 and TNF alpha ) , plasminogen activator inhibitor 1 ( PAI 1 ) and several routine laboratory parameters were determined and expressed as medians ( ranges ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To review the published evidence of a relationship between levels of plasminogen activator inhibitor 1 ( PAI 1 ) or the 4G / 5G polymorphism of the PAI 1 gene and the occurrence of venous thromboembolic disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fibrinolysis was quantified with measurement of the activities of tissue plasminogen activator ( tPA ; the activator of fibrinolysis ) and its inhibitor plasminogen activator inhibitor 1 ( PAI 1 ) with amidolytic technique . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Blood samples for plasminogen activator inhibitor 1 ( PAI 1 ) antigen and tissue plasminogen activator ( t PA ) antigen were obtained at baseline in all patients and control subjects . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : CSF and serum concentrations of urokinase plasminogen activator ( urokinase [ uPA ] ) , uPA receptor ( uPAR ) , and PA inhibitor 1 ( PAI 1 ) were quantified by ELISA in 12 patients with bacterial meningitis , control patients ( n = 10 ) with noninflammatory neurologic diseases , and 10 patients with Guillain Barr syndrome ( GBS ) , a disease in which blood CSF barrier disruption occurs without CSF pleocytosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We examined the diurnal pattern in Plasminogen Activator Inhibitor type 1 ( PAI 1 ) activity and Plasminogen activator ( t PA ) in relation to the 4G / 5G polymorphism in the promoter of the PAI 1 gene . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
An increase in homocysteine level was associated with a rise in plasminogen activator inhibitor ( PAI 1 ) , tissue plasminogen activator ( TPA ) antigen , von Willebrand factor and fibrinogen level . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The question whether the alcohol induced plasma increase of plasminogen activator inhibitor ( PAI 1 ) may originate from thrombocytes was also addressed . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
On the other hands , HRT has shown to enhance systemic fibrinolysis with decreased plasma plasminogen activator inhibitor 1 ( PAI 1 ) levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
DNA synthesis was assessed by measuring the incorporation of [ 3H ] thymidine into cellular DNA fraction . tPA , uPA and type 1 plasminogen activator inhibitor ( PAI 1 ) gene expressions were measured by Northern blotting . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is an inhibitor of the fibrinolytic system . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Interaction of plasminogen activator inhibitor type 1 ( PAI 1 ) with vitronectin ( Vn ) : mapping the binding sites on PAI 1 and Vn . ^^^ The serpin plasminogen activator inhibitor type 1 ( PAI 1 ) , as the primary physiological inhibitor of both urokinase type ( uPA ) and tissue type ( tPA ) plasminogen activator , plays an important role in the regulation of the fibrinolytic system as well as in extracellular remodeling in both physiological and pathophysiological processes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We demonstrate the efficiency of this method for two clinically relevant targets : ( 1 ) the 10 bp insertion / deletion polymorphism in the promoter of the factor VIIc ( F VIIc ) gene and ( 2 ) the 4G / 5G single nucleotide polymorphism in the promoter of the plasminogen activator inhibitor 1 ( PAI 1 ) gene . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We hypothesize that a genetic variant of the plasminogen activator inhibitor 1 ( PAI 1 ) determines the risk of AVN in glucocorticoid treated patients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In 100 healthy individuals and 129 patients with venous thromboembolism , we have determined antigenic FVIII levels along with several endothelial proteins including vWF , soluble thrombomodulin ( sTM ) , tissue type plasminogen activator ( t PA ) , and plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The parameters examined were tissue type plasminogen activator ( t PA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Impaired fibrinolysis with elevated plasminogen activator inhibitor 1 ( PAI 1 ) activity is associated with resistance to fibrinolytic therapy in AMI patients , but it is also found in patients with AF . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Overexpression of plasminogen activator inhibitor 1 ( PAI 1 ) reduces tumor cell migration in vitro and metastasis in mice in vivo by mechanisms involving either inhibition of urokinase plasminogen activator ( u PA ) activity or competition for an integrin binding site on vitronectin . ^^^ The mutant PAI 1 proteins were defective in either vitronectin binding ( PAI 1 ( VN ) ) , plasminogen activator inhibition ( PAI 1 ( INH ) ) or both ( PAI 1 ( VN , INH ) ) . ^^^ Migration of cells infected by virus expressing either PAI 1 ( INH ) or PAI 1 ( VN , INH ) was unaffected , indicating a requirement for plasminogen activator inhibitory activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Expression of the prothombotic protein plasminogen activator inhibitor 1 ( PAI 1 ) is known to be regulated by NO * and was increased in the left atrium by 1 . 8 fold in AF ( P < 0 . 05 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : Measurement of platelet number , plasma levels of fibrinogen , tissue plasminogen activator ( t PA ) antigen , plasminogen activator inhibitor 1 ( PAI 1 ) activity , and fibrin fragment D dimer . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Specific mutations at three sites in the alteplase molecule result in 15 fold higher fibrin specificity , 80 fold reduced binding affinity to the physiological plasminogen activator inhibitor PAI 1 and 6 fold prolonged plasma half life ( 22 vs 3 . 5 minutes ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) has been associated with postnatal organ fibrosis . ^^^ We hypothesized that the relative balance between urokinase type plasminogen activator ( uPA ) and PAI 1 expression in favor of uPA prevents scarring in early fetal skin wounds , whereas a change in favor of PAI 1 in late gestation results in wound scarring . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To investigate the relationship between coagulation activities and the fibrinolytic system during normal pregnancy , we measured the plasma concentrations of coagulation factors , antithrombin 3 ( AT 3 ) , D dimer , tissue plasminogen activator ( tPA ) , total protein S ( TPS ) , and plasminogen activator inhibitor type 1 ( PAI 1 ) in 436 apparently healthy pregnant , postpartum , and nonpregnant women . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Serum components , such as lipoproteins , coagulation factors ( factor 7 , tissue plasminogen activator ( tPA ) , plasminogen activator inhibitor 1 ( PAI 1 ) , fibrinogen ) , and homocysteine have been associated with cardiovascular disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The regulated expression of the urokinase type plasminogen activator ( uPA ) and plasminogen activator inhibitor ( PAI 1 ) is believed to modulate the invasive capacity of human trophoblastic cells in vitro and in vivo . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
When injected s . c . in athymic mice , PANC 1 clones expressing sT beta RII exhibited decreased tumor growth in comparison with sham transfected cells and attenuated expression of plasminogen activator inhibitor 1 ( PAI 1 ) , a gene associated with tumor growth . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
ACE inhibition reduces plasminogen activator inhibitor 1 ( PAI 1 ) , a risk factor for myocardial infarction , whereas the effect of angiotensin receptor antagonism on PAI 1 is uncertain . ^^^ Hydrochlorothiazide increased plasma PAI 1 ( P=0 . 013 ) but not tissue type plasminogen activator ( tPA ) ( P=0 . 431 ) antigen . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
AIMS : Since infection of endothelial or smooth muscle cells with Chlamydia pneumoniae increased expression of tissue factor and plasminogen activator inhibitor 1 ( PAI 1 ) , C . pneumoniae might be involved in triggering acute thrombotic events in patients with coronary artery disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : We previously reported that plasminogen activator inhibitor 1 ( PAI 1 ) , in the presence of vitronectin ( VN ) , inhibits thrombin activity in vitro . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In addition , fibrinolytic factors ( plasminogen activator inhibitor 1 ( PAI 1 ) , tissue plasminogen activator ( tPA ) and fibrinogen ) were measured in patients who received fibrinolysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is a factor in urokinase type plasminogen activator proteolytic system , which is important for tumour invasion and metastasis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is a serpin that suppresses fibrinolysis by inhibiting the activity of plasminogen activator ( PA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
AIMS / HYPOTHESIS : Plasminogen activator inhibitor 1 ( PAI 1 ) increases in several insulin resistant conditions such as obesity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Cerivastatin , a HMG CoA reductase inhibitor , reduces plasminogen activator inhibitor 1 ( PAI 1 ) expression in endothelial cells by down regulation of cellular signaling and the inhibition of PAI 1 promoter activity . ^^^ In this report , molecular mechanisms of the inhibitory effect on plasminogen activator inhibitor type 1 ( PAI 1 ) expression produced by cerivastatin ( CRV ) , the most active compound in this class , were studied using monocultures of human endothelial cell line ( EA . hy 926 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The following inflammatory parameters were measured : tumour necrosis factor alpha ( TNF alpha ) , plasminogen activator inhibitor 1 ( PAI 1 ) , interleukin 1beta ( IL 1beta ) , IL 6 , IL 10 , microCRP and tissue factor ( TF ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Direct binding of Nur77 / NAK 1 to the plasminogen activator inhibitor 1 ( PAI 1 ) promoter regulates TNF alpha induced PAI 1 expression . ^^^ Plasminogen activator inhibitor 1 ( PAI 1 ) is the main fibrinolysis inhibitor , and high plasma levels are associated with an increased risk for vascular diseases . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma levels of plasmin plasmin inhibitor complex and tissue type plasminogen activator / plasminogen activator inhibitor 1 complex ( PAI 1 ) were significantly higher in patients with low fibrinogen than in those with high fibrinogen . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
It is now widely accepted that white adipose tissue ( WAT ) secretes a number of peptide hormones , including leptin , several cytokines , adipsin and acylation stimulating protein ( ASP ) , angiotensinogen , plasminogen activator inhibitor 1 ( PAI 1 ) , adiponectin , resistin etc . , and also produces steroids hormones . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Similarly , plasma concentrations of plasminogen activator inhibitor 1 ( PAI 1 ) have been shown to be higher in obese patients as compared to non obese controls and to be directly correlated with visceral fat . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Second messengers involved in the signal transduction pathway leading to induction of the plasminogen activator inhibitor ( PAI 1 ) have not yet been well characterized . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The fundamental role in the regulation of fibrinolysis is played by plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) protein expression in tumor cells was determined to verify the biological activity of TGF beta ( 1 . ) Cytoplasmatic TGF beta ( 1 ) mRNA expression in tumor cells was significantly correlated with the amount of intratumoral stroma and the deposition of collagen 4 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
RESULTS : Trophoblast proteases , matrix metalloproteases ( MMP 2 , MMP 9 ) , membrane type matrix metalloproteases ( MT MMP 1 & 2 ) and urokinase type plasminogen activator ( uPA ) were found to be up regulated by IL 1beta while the protease inhibitors , tissue inhibitor of metalloproteases ( TIMP 1 & 2 ) and plasminogen activator inhibitors ( PAI 1 & 2 ) to be up regulated by TGF beta 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Von Willebrand factor , tissue plasminogen activator ( t PA ) , plasminogen activator inhibitor 1 ( PAI 1 ) and thrombomodulin were also measured . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To determine whether normal peritoneal and adhesion fibroblasts express tissue plasminogen activator ( tPA ) and plasminogen activator inhibitor ( PAI 1 ) and whether their expression is regulated by oxygen . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : The objective of this study was to investigate the role of plasminogen activator inhibitor 1 ( PAI 1 ) in adipose tissue development in vivo . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Here we found that the serine protease tissue plasminogen activator ( tPA ) was upregulated in the central and medial amygdala by acute restraint stress , where it promoted stress related neuronal remodeling and was subsequently inhibited by plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Five week old male mice were kept on standard chow ( SFD ) or on high fat diet ( HFD ) for 15 weeks , and subcutaneous ( SC ) and gonadal ( GON ) adipose tissue , as well as mature adipocytes and stromal vascular ( S 5 ) cells were harvested . mRNA levels of plasminogen activator inhibitor 1 ( PAI 1 ) , tumor necrosis factor alpha ( TNF alpha ) , ADAM 17 ( TACE or TNF alpha converting enzyme ) , ADAMTS 1 and ADAMTS 8 were quantified in isolated adipose tissues and cell fractions , and during differentiation of murine preadipocytes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The prognostic significance of TN was also compared to that of plasminogen activator inhibitor 1 ( PAI 1 ) , urokinase plasminogen activator ( uPAR ) and carcinoembryonic antigen ( CEA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Age and sex adjusted HOMA was correlated to waist hip ratio ( r = 0 . 38 , p = 0 . 0001 ) , triglycerides ( r = 0 . 22 , p = 0 . 03 ) , systolic blood pressure ( r = 0 . 21 , p = 0 . 04 ) , tissue plasminogen activator ( t PA ) ( r = 0 . 22 , p = 0 . 04 ) ; plasminogen activator inhibitor 1 ( PAI 1 ) ( r = 0 . 26 , p = 0 . 02 ) ; fibrinogen ( r = 0 . 25 , p = 0 . 02 ) ; and factor 7 antigen ( r = 0 . 21 , p = 0 . 06 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Little is known about the modulating effect of NO on the endothelial overexpression and production of tissue factor ( TF ) and plasminogen activator inhibitor 1 ( PAI 1 ) occurring in endotoxemia . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : The roles of urokinase type plasminogen activator ( uPA ) and plasminogen activator inhibitor 1 ( PAI 1 ) in the formation of macroscopic types and invasion were investigated . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Serum leptin , glucose , insulin , lipid profile , sex hormone binding globulin ( SHBG ) , plasminogen activator inhibitor 1 ( PAI 1 ) , tissue plasminogen activator ( t PA ) and fibrinogen were all measured . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To compare plasma plasminogen activator inhibitor type 1 ( PAI 1 ) levels and to examine the association of PAI 1 with visceral adiposity and other components of the metabolic syndrome in overweight and obese premenopausal African American ( AA ) and Caucasian ( CC ) women . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have chosen plasminogen activator inhibitor ( s ) type 1 ( PAI 1 ) , which selectively inhibits the urokinase plasminogen activator ( uPA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor type 1 ( PAI 1 ) acts as a negative regulator . ^^^ This system is complicated by a poorly understood intrinsic reactivity of the uPA pro enzyme ( pro uPA ) before proteolytic activation , directed against both plasminogen and PAI 1 . ^^^ However , in spite of this very fast inhibition , two chain uPA still became the dominant plasminogen activator when plasminogen was incubated with pro uPA and PAI 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the present study , we analyzed the gene expression of plasminogen activator inhibitor 1 ( PAI 1 ) , a key molecule in the development of thrombosis , in a murine model of aging , klotho mutant ( kl / kl ) mice . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The recent epidemic in obesity may heighten thrombotic risks in the elderly because adipose tissue is an important source of inflammatory cytokines and plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : Vascular endothelial growth factor ( VEGF ) and plasminogen activator inhibitor 1 ( PAI 1 ) were determined by ELISA methods in plasma collected from the patients before treatment and after 1 , 3 and 6 months . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
SPUC was 2 3 fold more effective in lysis of surfactant containing clots and 5 fold more resistant against plasminogen activator 1 ( PAI 1 ) as compared to the native u PA . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Interfering with increased levels of plasminogen activator inhibitor 1 ( PAI 1 ) might offer new therapeutic strategies for a variety of cardiovascular diseases . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Assessments included tissue Plasminogen Activator ( t PA ) , Plasminogen Activator Inhibitor 1 antigen ( PAI 1 Ag ) , Plasminogen Activator Inhibitor 1 activity ( PAI 1 Act ) , Plasminogen ( Pl ) , Fibrin peptide A ( FPA ) , Fibrinogen ( Fr ) , and the ankle / brachial pressure index ( ABI ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BMI had significant genetic correlations with fasting insulin , systolic blood pressure ( sBP ) , plasminogen activator activator inhibitor 1 ( PAI 1 ) and fibrinogen and triglyceride . ^^^ PAI 1 and tissue plasminogen activator ( t PA ) showed significant genetic correlation with sBP and with each other . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Besides degrading of matrix proteins , PMN E has been shown to be able to cleave and inactivate plasminogen activator inhibitor 1 ( PAI 1 ) , the main inhibitor of uPA , and alpha 2 antiplasmin , the natural inhibitor of plasmin , thus enabling an uncontrolled matrix degradation by the fibrinolytic enzymes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Extracellular proteolysis by HRPE uPAR was evaluated using fluorescent bodipy BSA and assessed for specificity by plasminogen activator inhibitor 1 ( PAI 1 ) inhibition . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) , a marker of atherothrombosis , is also elevated in the metabolic syndrome and in diabetes , and endothelial cells are the major source of PAI 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The basic helix loop helix leucine zipper ( bHLHZIP ) protein TFE 3 and Smad 3 synergistically activate transcription of the plasminogen activator inhibitor 1 ( PAI 1 ) as well as other genes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Both urokinase like plasminogen activator ( uPA ) and its inhibitor plasminogen activator inhibitor ( PAI 1 ) , as well as uPA PAI 1 complexes , have been identified as important prognostic factors in breast cancer . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tumour angiogenesis and the levels of plasminogen activator inhibitor type 1 ( PAI 1 ) are both informative prognostic markers in breast cancer . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Role of PAI 1 plasminogen activator inhibitor in tumor invasion and angiogenesis ] . ^^^ High levels of components of the plasminogen activation system , and paradoxically also its inhibitor , plasminogen activator inhibitor 1 ( PAI 1 ) , have been correlated with a poor prognosis for patients with cancers of different types . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The following parameters were determined at hospital discharge : plasma viscosity , whole blood viscosity , erythrocyte membrane fluidity , erythrocyte aggregation , protein C , plasminogen inhibitor type 1 ( PAI 1 ) , leukocyte count and elastase . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In contrast , a remarkable increase in the mRNA level of plasminogen activator inhibitor 1 ( PAI 1 ) was found in the testis , suggesting the activation of PPARgamma . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : When different concentration of 17 beta estrodial including 10 ( 10 ) mol / L ( the group E 1 ) , 10 ( 8 ) mol / L ( the group E 2 ) , 10 ( 6 ) mol / L ( the group E 3 ) were treated in original cultured HUVEC , the changes of tissue plasminogen activator ( t PA ) and plasminogen activator inhibitor ( PAI 1 ) were measured by spectrophotometric assay , and the level of message RNA were examined by in situ hybridization . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Other phenotype markers including plasminogen activator inhibitor 1 ( PAI 1 ) and beta actin mRNAs were also significantly increased by argatroban . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fasting blood samples for determination of tPA and plasminogen activator inhibitor ( PAI 1 ) enzyme activities were obtained before , immediately after , and 60 min after submaximal treadmill walking . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Stromal cells also contribute to breast cancer growth and metastasis through the production of extracellular matrix ( ECM ) modifiers such as urokinase type plasminogen activator ( uPA ) , its receptor ( uPAR ) , its inhibitors ( PAI 1 and PAI 2 ) , matrix metalloproteinases ( MMPs ) , and growth factors , including the fibroblast and insulin like growth factors ( FGF ' s and IGF ' s ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To explore the action of platelet surface activity protein ( platelet granule membrane protein CD 63 and lysosome membrane protein CD62P ) , plasminogen activator inhibitor ( PAI 1 ) and C reactive protein ( C RP ) in occurrence and development of unstable angina pectoris ( UAP ) , and the effect of Puerarin on them . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : Plasma RAS levels and plasminogen activator inhibitor ( PAI 1 ) activity were measured in 2 groups of rats : the sham operated group ( Group A ) and the HF with Heart Qi deficiency Syndrome model group ( Group B ) established by making arteriovenous fistula . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The expression of factors of the urokinase type plasminogen activation system , including the urokinase type plasminogen activator ( u PA ) and the plasminogen activator inhibitor type 1 ( PAI 1 ) , which have been described to be frequently implicated in the process of degradation of the extracellular matrix during the metastatic process , were also analyzed . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Do plasminogen activator inhibitor ( PAI 1 ) or tissue plasminogen activator PAI 1 complexes predict complications in Type 1 diabetes : the Pittsburgh Epidemiology of Diabetes Complications Study . ^^^ AIMS : To examine the predictive power of plasminogen activator inhibitor 1 ( PAI 1 ) and the complexes it forms with tissue plasminogen activator ( tPA PAI 1 ) for the two major Type 1 diabetes ( T1D ) complications ( coronary artery disease ( CAD ) and overt nephropathy ) in the context of standard risk factors . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The changes of fasting blood glucose ( FBG ) , fasting plasma insulin ( FINS ) , plasma total cholesterol ( TC ) , triglyceride ( TG ) , low and high density lipoprotein cholesterol ( LDL C & HDL C ) and plasminogen activator inhibitor 1 ( PAI 1 ) activity were measured before and after treatment , and the insulin sensitivity index ( ISI ) calculated . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue plasminogen activator ( t PA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) may be involved in the pathogenesis of peptic ulcers through suppression of fibrinolysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The magnitude of this effect , which refers to the AAA patients unselected for familial occurrence , indicates that the disturbance of aortic wall physiology caused by the presence of the MTHFR 677T allele is greater than the effect of the earlier described allele disequilibrium at the polymorphic alleles of the PAI 1 ( plasminogen activator inhibitor 1 ) gene seen only in familial cases of AAA . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We sought to evaluate the role of AT 1 agonistic autoantibodies ( AT 1 AA ) in two major features of preeclampsia increased plasminogen activator inhibitor 1 ( PAI 1 ) production and shallow trophoblast invasion . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
PDGF BB stimulation of MC increased mRNA for transforming growth factor beta 1 ( TGF beta 1 ) , monocyte chemoattractant protein 1 ( MCP 1 ) , and plasminogen activator inhibitor 1 ( PAI 1 ) and increased the cell numbers . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
High plasma plasminogen activator inhibitor 1 ( PAI 1 ) concentrations have been reported in coronary artery disease and stroke . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tumor necrosis factor alpha ( TNF alpha ) is elevated in obesity and in acute inflammatory states , and contributes to the elevated plasminogen activator inhibitor 1 ( PAI 1 ) levels associated with these conditions . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The association between plasminogen activator inhibitor 1 ( PAI 1 ) and insulin resistance is established in western countries . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor type 1 ( PAI 1 ) , competes with alphavbeta 3 integrin for vitronectin ( VN ) binding . ^^^ By using specific PAI 1 mutants with either VN binding or plasminogen activator ( PA ) inhibiting activities ablated , we have shown that the PAI 1 mediated interference with insulin signaling occurs through its direct interaction with VN , and not through its PA neutralizing activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The mechanism for the conversion of plasminogen activator inhibitor 1 ( PAI 1 ) from the active to the latent conformation is not well understood . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : Patients with highly active antiretroviral therapy associated lipodystrophy ( HAART+LD+ ) have high plasminogen activator inhibitor 1 ( PAI 1 ) concentrations for unknown reasons . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The mechanism appears to be due to decreased oxidative inactivation of plasminogen activator inhibitor 1 ( PAI 1 ) in the MPO ( / ) , leading to decreased tissue plasmin activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma levels of haemostasis factors ( HFs ) such as fibrinogen , tissue type plasminogen activator ( t PA ) , plasminogen activator inhibitor 1 ( PAI 1 ) and D dimer may be markers of arteriosclerosis for the following reasons : There seems to be no difference in levels of HFs between patients with longstanding stable angina and those with an isolated myocardial infarction . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In fibrinolysis , a clear reduction in plasminogen activator inhibitor 1 ( PAI 1 ) was observed , but no significant change in tissue type plasminogen activator antigen ( t PA Ag ) or activity was found , although fibrinolytic activity assessed as t PA activity ( t PA Act ) tended to increase after oERT . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
MATERIALS AND METHODS : Plasminogen activators ( t PA and u PA ) and their inhibitors ( PAI 1 and PAI 2 ) secretions were assayed in cultures of epithelial , stromal , and trophoblast cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : Protein expression of the PAS , including urokinase type plasminogen activator ( uPA ) and its receptor ( uPAR ) , plasminogen ( Plg ) , and plasminogen activator inhibitors 1 and 2 ( PAI 1 and PAI 2 ) , was determined in the colonic tissue samples of 56 patients with resected primary CRC by quantitative immunohistochemistry and correlated with clinicopathological parameters and patient outcome . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activators ( PAs ) are known to be a major pathway of MMP activation , and this suggests that their inhibitor , plasminogen activator inhibitor 1 ( PAI 1 ) , also plays important roles in the development of CALs in KD . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have investigated whether there are any differences in the release of urokinase plasminogen activator ( uPA ) and its inhibitor ( PAI 1 ) from cultured endometrial and endometriotic stromal cells , and whether the release is regulated by epidermal growth factor ( EGF ) or transforming growth factor beta 1 ( TGFbeta 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
An increased plasma plasminogen activator inhibitor 1 ( PAI 1 ) level is a risk factor for myocardial infarction , particularly when associated with visceral obesity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
After 40 days mouse survival , albuminuria , matrix accumulation , inflammatory cell infiltration , immunoglobulin G ( IgG ) deposition , expression of transforming growth factor beta 1 ( TGF beta 1 ) , fibronectin and plasminogen activator inhibitor 1 ( PAI 1 ) mRNA and protein , anti DNA antibody titer , inducible nitric oxide synthase ( iNOS ) mRNA expression , blood amino acid levels , blood urea nitrogen ( BUN ) concentrations and blood and urinary NOx ( nitrite + nitrate ) levels were assessed . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Congenital plasminogen activator inhibitor 1 ( PAI 1 ) deficiency is an extremely rare disorder characterized by a bleeding diathesis due to hyperfibrinolysis as a result of decreased PAI 1 activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Secondary efficacy variables were HbA ( 1c ) response ( rated as excellent , good , or marginal ) and changes in FPG , fasting insulin , fibrinogen , and plasminogen activator inhibitor 1 ( PAI 1 ) levels from baseline to study end point . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Ad DN ERK inhibited PDGF BB induced plasminogen activator inhibitor type 1 ( PAI 1 ) , monocyte chemoattractant protein 1 , and transforming growth factor beta 1 expressions , Ad DN p 38 blocked monocyte chemoattractant protein 1 and transforming growth factor beta 1 expression but not PAI 1 , whereas Ad DN JNK suppressed only PAI 1 expression . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
PURPOSE : The independent clinical relevance of invasion factors urokinase type plasminogen activator ( uPA ) / PAI 1 and HER 2 status was evaluated in lymph node negative breast cancer patients ( N = 118 ) without adjuvant systemic therapy after long term follow up of more than 10 years ( median , 126 months ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In vascular injury models , Serp 1 altered early cellular plasminogen activator ( tissue plasminogen activator ) , inhibitor ( PAI 1 ) , and receptor ( urokinase type plasminogen activator ) expression ( p < 0 . 01 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The plasminogen / plasmin system , urokinase type plasminogen activator ( uPA ) , its receptor ( uPAR ) , and its inhibitor ( PAI 1 ) , influence extracellular proteolysis and cell migration in lung injury or neoplasia . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Before HD , the plasma levels of fibrinogen , plasmin plasmin inhibitor complex ( PIC ) , thrombomodulin ( TM ) , and D dimer were increased , while the plasma levels of protein C ( PC ) , antithrombin ( AT ) , thrombin antithrombin complex ( TAT ) , and tissue plasminogen activator ( tPA ) plasminogen activator inhibitor 1 ( PAI 1 ) complex ( tPA PAI 1 complex ) were decreased . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Postmortem analysis of plasma samples obtained after the transfusions revealed unexpectedly elevated levels of plasminogen activator inhibitor 1 ( PAI 1 ) antigen and activity associated with a nonmeasurable euglobulin clot lysis time , disclosing extreme hypofibrinolysis , which might facilitate coronary thrombosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : Levels of hemostatic factors ( vWF , plasminogen activator inhibitor type 1 ( PAI 1 ) , antithrombin 3 ( ATIII ) , in tissue sections and cultured endothelial cells of canine femoral arteries and canine femoral veins were compared by the immunohistochemistry technique . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To determine the efficacy of 4 different fibrinolysis system parameters , namely , tissue plasminogen activator ( tPA ) , tissue plasminogen activator inhibitor type 1 ( PAI 1 ) , plasmin antiplasmin complexes ( PAP ) , and D dimer , in the diagnosis of acute PE . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Morphometric analysis of aorta was also performed and plasminogen activator inhibitor 1 ( PAI 1 ) as well as tissue type plasminogen activator ( t PA ) plasma activities were measured . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Negatively charged organochemical inactivators of the anti proteolytic activity of plasminogen activator inhibitor 1 ( PAI 1 ) convert it to inactive polymers . ^^^ During incubation with urokinase type plasminogen activator , the polymers were slowly converted to reactive centre cleaved monomers , indicating substrate behaviour of the terminal PAI 1 molecules in the polymers . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Experimental studies have shown that lipoproteins or mevalonate regulate matrix metalloproteinase ( MMP ) 9 , tissue factor ( TF ) , plasminogen activator inhibitor 1 ( PAI 1 ) expression , providing nonlipid mechanism . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Ac SDKP inhibited TGF beta 1 induced plasminogen activator inhibitor 1 ( PAI 1 ) and alpha 2 ( 1 ) collagen mRNA . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In an association study , the relationship between the insertion / deletion ( I / D ) plasminogen activator inhibitor 1 ( PAI 1 ) gene polymorphism or the I / D angiotensin 1 converting enzyme ( ACE ) gene polymorphism and the development of diabetic retinopathy in patients with type 2 diabetes was investigated . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We confirmed the findings of gene array expression and quantified the changes in expression in VF of genes involved in insulin resistance ( PPARgamma leptin ) and its syndrome ( angiotensinogen and plasminogen activating inhibitor 1 , PAI 1 ) by real time PCR ( qRT PCR ) technology . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The aim of this study was to examine glucocorticoid effect on plasminogen activator inhibitor 1 ( PAI 1 ) , tumour necrosis factor alpha ( TNFalpha ) , leptin and interleukin 6 ( IL 6 ) adipose tissue secretion . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The aim of this study was to evaluate the effect of fenofibrate on the plasma levels of Plasminogen Activator Inhibitor type 1 ( PAI 1 ) and fibrinogen in patients with combined dyslipidemia . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To investigate the effect of peroxisome proliferator activated receptors ( PPARs ) activators on plasminogen activator inhibitor 1 ( PAI 1 ) expression in human umbilical vein endothelial cells and elucidate a possible mechanism . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Under hypoxic conditions , the expression of plasminogen activator inhibitor 1 ( PAI 1 ) is mainly controlled by the hypoxia inducible factor HIF 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Biguanides and thiazolidinediones ( TZDs ) , which are primarily used as anti diabetic drugs , are also associated with other beneficial effects on cardiovascular risk factors such as reduced plasma plasminogen activator inhibitor 1 ( PAI 1 ) concentration in both diabetic and non diabetic obese subjects . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND AND AIM : Concentrations in blood of plasminogen activator inhibitor type 1 ( PAI 1 ) and circulating free ( non esterified ) fatty acids ( FFA ) are increased in diabetes and may accelerate atherosclerosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Gene expression profile of ECs subjected to heat shock demonstrates that plasminogen activator inhibitor 1 ( PAI 1 ) , a protein involved in the control of extracellular matrix degradation , is specifically up regulated . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tumor tissue concentrations of the proteinase inhibitors tissue inhibitor of metalloproteinases 1 ( TIMP 1 ) and plasminogen activator inhibitor type 1 ( PAI 1 ) are complementary in determining prognosis in primary breast cancer . ^^^ The purpose of this study was to investigate the association between tumor tissue levels of total tissue inhibitor of metalloproteinases 1 ( TIMP 1 ) and prognosis in patients with primary breast cancer and to analyze whether measurement of TIMP 1 in tumor extracts added prognostic information to that obtained from measurements of urokinase type plasminogen activator and plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Another effect of DD , namely , stimulation of plasminogen activator inhibitor 1 ( PAI 1 ) secretion did not depend on the NO level . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Interaction between genotype and diabetes status was estimated for nine CVD risk factors [ body fat mass ( FAT ) , body mass index ( BMI ) , high density lipoprotein cholesterol ( HDL C ) , log transformed fibrinogen , log transformed triglycerides , log transformed urinary albumin : creatinine ratio ( LACR ) , plasminogen activator inhibitor 1 ( PAI 1 ) , systolic blood pressure ( SBP ) , and waist to hip ratio ( WHR ) ] , using a maximum likelihood variance decomposition technique . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) and nuclear factor kappa B ( NF kappaB ) are major factors known to promote tubulointerstitial fibrosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Type 1 plasminogen activator inhibitor ( PAI 1 ) is a 50 kDa glycoprotein belonging to the serine protease superfamily . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
MATERIALS AND METHODS : MMPs , TIMPs , plasminogen activators and PAI 1 as well as growth rate and adhesion to fibronectin were assessed . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Locally increased amplification of plasminogen activator inhibitor 1 ( PAI 1 ) is largely responsible for this fibrinolytic defect . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The urokinase type plasminogen activator ( uPA ) and its inhibitors type 1 ( PAI 1 ) and type 2 ( PAI 2 ) are considered to have a key role in the process of invasion and metastasis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Using adenovirus mediated transfection method , we demonstrated that overexpression of Smad 2 or Smad 4 was associated with an increased production of TGF beta 1 induced plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The serpin plasminogen activator inhibitor 1 ( PAI 1 ) plays an important role in the regulation of the fibrinolytic activity in blood . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We measured markers of endothelial function [ von Willebrand factor ( vWf ) , soluble intercellular adhesion molecule 1 ( sICAM 1 ) , soluble vascular cell adhesion molecule 1 ( sVCAM 1 ) , tissue type plasminogen activator ( tPA ) , plasminogen activator inhibitor 1 ( PAI 1 ) and E selectin ( ES ) ] , and markers of inflammatory activity [ secretory phospholipase A ( 2 ) ( sPLA ( 2 ) ) and C reactive protein ( CRP ) ] . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The 4G / 4G genotype of the 4G / 5G polymorphism of the type 1 plasminogen activator inhibitor ( PAI 1 ) gene is a determinant of penetrating behaviour in patients with Crohn ' s disease . ^^^ AIM : To assess the effect of the 4G / 5G polymorphism of the type 1 plasminogen activator inhibitor ( PAI 1 ) gene , the major inhibitor of fibrinolysis , on Crohn ' s disease susceptibility and phenotype . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) belongs to the serpin family of serine proteinase inhibitors . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The serpin plasminogen activator inhibitor 1 ( PAI 1 ) is a fast and specific inhibitor of the plasminogen activating serine proteases tissue type and urokinase type plasminogen activator and , as such , an important regulator in turnover of extracellular matrix and in fibrinolysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Impaired fibrinolytic capacity caused by an increase in plasminogen activator inhibitor type 1 ( PAI 1 ) levels is involved in the onset of atherosclerosis and thrombotic complications . ^^^ The following were assayed : euglobulin lysis time , tissue type plasminogen activator antigen , and PAI 1 antigen and activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
On the other hand , serum concentrations of TGF beta , plasminogen activator inhibitor type 1 ( PAI 1 ) , and vascular endothelial growth factor ( VEGF ) are elevated as tumor progresses . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
For certain genes ( e . g . , urokinase plasminogen activator and its type 1 inhibitor PAI 1 ) , de novo mRNA synthesis appears to require cell shape dependent activation of the MAP kinases ERK1 / 2 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Immunohistochemical studies revealed that although dermal fibroblasts of normal scars and keloids expressed both urokinase type plasminogen activator ( uPA ) and plasminogen activator inhibitor 1 ( PAI 1 ) , keloid fibroblasts had a much higher PAI 1 expression . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Absence of the uPAR scavenger receptor was associated with significantly greater accumulation of plasminogen activator inhibitor 1 protein ( PAI 1 ) ( 20 . 5 + / 3 . 5 versus 9 . 1 + / 2 . 9 % area , day 14 UUO ) and vitronectin protein ( 2 . 4 + / 1 . 1 versus 0 . 9 + / 0 . 4 % area , day 14 UUO ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Cancer tissues from 101 gastric cancer patients were assayed immunohistochemically for expression of urokinase type plasminogen activator ( uPA ) , uPA receptor ( uPAR ) , PA inhibitor 1 ( PAI 1 ) and VEGF protein . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Thrombomodulin ( TM ) slows down the interaction rate between thrombin and plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Increased localized procoagulant components such as tissue factor ( TF ) and plasminogen activator inhibitors ( PAI 1 , PAI 2 ) , are associated with some pregnancy complications . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) and two chain high molecular weight kininogen ( HKa ) exert anti adhesive properties in vitronectin dependent cell adhesion . ^^^ In atherosclerotic vessel sections , congruent distribution of vitronectin , PAI 1 , HK , and of components of the urokinase plasminogen activator / receptor system with apoptotic cells lining foam cell lesions was demonstrated by immunostaining . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor type 1 ( PAI 1 ) and platelet glycoprotein IIIa ( PGIIIa ) polymorphisms in Black South Africans with pre eclampsia . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor type 1 ( PAI 1 ) is increased in the presence of hypertriglyceridemia . ^^^ When the data were pooled , the saturated ( S , P , and M ) test fats resulted in a smaller postprandial increase in FVIIa ( P = 0 . 036 , diet effect ) , a smaller increase in FVII : c ( P < 0 . 001 , diet 10 time interaction ) , a greater rise in tissue plasminogen activator concentrations ( P = 0 . 028 , diet effect ) , and a tendency to a greater postprandial decline in PAI 1 ( P = 0 . 06 , diet effect ) compared with the unsaturated test fats ( O , T , and L ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : The 4G / 5G polymorphism of the plasminogen activator inhibitor 1 ( PAI 1 ) gene has been related to cardiovascular disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The hypoxia inducible transcription factor HIF 1 mediates upregulation of plasminogen activator inhibitor 1 ( PAI 1 ) expression under hypoxia . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Furthermore , semiquantitative reverse transcription ( RT ) polymerase chain reaction ( PCR ) analysis of a panel of genes involved in the plasminogen activation system , including plasminogen activator inhibitor 1 ( PAI 1 ) , urokinase plasminogen activator ( u PA ) , and urokinase receptor ( u PAR 1 ) , demonstrated a significant upregulation ( approximately fourfold to sixfold , P < 0 . 05 ) in the expression of each of these genes in the tumor tissue . ^^^ Overall , the present study demonstrates a very low plasmin activity in A / J colon tumors , possibly as a result of the potent inhibitory effect of PAI 1 on the plasminogen activation cascade . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
XR 5118 [ ( 3 Z , 6 Z ) 6 benzylidine 3 ( 5 ( 2 dimethylaminoethyl thio ) ) 2 ( thienyl ) methylene 2 , 5 dipiperazinedione hydrochloride ] can inactivate the anti proteolytic activity of the serpin plasminogen activator inhibitor 1 ( PAI 1 ) , a potential therapeutic target in cancer and cardiovascular diseases . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Multivariate genetic analysis was performed using a total of 314 ( 107 monozygotic and 207 dizygotic ) twin pairs on IR assessed by HOMA , fibrinogen , plasminogen activator inhibitor ( PAI 1 ) , tissue plasminogen activator ( tPA ) , factor 8 ( FVIII ) , von Willebrand factor ( vWF ) and factor 13 B subunit . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) , ischemic heart disease and diabetes mellitus ] . ^^^ Plasminogen activator inhibitor type 1 ( PAI 1 ) , the main human regulator of endogenous fibrinolysis , is considered to be an important cardiovascular risk factor . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor type 1 ( PAI 1 ) plays an important role in the events of cardiovascular pathophysiology . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Human adipose tissue can produce plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Circadian variation in plasminogen activator inhibitor 1 ( PAI 1 ) production likely contributes to increased risk of myocardial infarction and decreased efficacy of thrombolytic therapy during the morning . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
STUDY DESIGN : The supernatants of Porphyromonas endodontalis , Porphyromonas gingivalis , and Prevotella intermedia were used to evaluate tissue type plasminogen activator ( t PA ) and type 1 plasminogen activator inhibitor ( PAI 1 ) gene expression in human pulp and osteoblastic cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We determined the extent to which plasminogen activator inhibitor type 1 ( PAI 1 ) expression in donor tissue influences intimal proliferation ( IP ) in a mouse model of AVD . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The processes of ovarian cancer dissemination are characterized by altered local proteolysis , cellular proliferation , cell attachment , and invasion , suggesting that the urokinase type plasminogen activator ( uPA ) and its specific inhibitor ( plasminogen activator inhibitor type 1 ( PAI 1 ) ) could be involved in the pathogenesis of peritoneal dissemination . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Type 1 plasminogen activator inhibitor ( PAI 1 ) is the primary inhibitor of both tissue and urokinase type plasminogen activators ( t PA , u PA ) and is thus a primary regulator of plasminogen activation and possibly of extracellular proteolysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Role of plasminogen activator inhibitor 1 ( PAI 1 ) levels in the diagnosis of BMT associated hepatic veno occlusive disease and monitoring of subsequent therapy with defibrotide ( DF ) . ^^^ Plasminogen activator inhibitor 1 ( PAI 1 ) has been proposed as a specific marker of VOD [ 1 ] . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have prospectively evaluated the effect of plasminogen activator inhibitor 1 ( PAI 1 ) 4G / 5G and angiotensin converting enzyme ( ACE ) insertion / deletion ( I / D ) polymorphisms on the occurrence of MI in uraemics . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
MAIN OUTCOME MEASURE ( S ) : Concentrations of total and active transforming growth factor beta 1 ( TGF beta 1 ) , tumor necrosis factor alpha ( TNF alpha ) , tissue type plasminogen activator ( t PA ) , urokinase plasminogen activator ( uPA ) , and plasminogen activator inhibitor 1 ( PAI 1 ) were obtained . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVES : In addition to assessing the effects of repaglinide and glimepiride on glycemic control in patients with type 2 diabetes mellitus , this study also examined the effects of these agents on 3 metabolic parameters known to be cardiovascular risk factors lipoprotein ( a ) ( Lp [ a ] ) , plasminogen activator inhibitor 1 ( PAI 1 ) , and homocysteine ( Hcy ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : Because obesity and insulin resistance ( IR ) are strongly associated with liver steatosis ( LS ) , we investigated the relation between the degree of LS and plasminogen activator inhibitor 1 ( PAI 1 ) in ob / ob mice , in C57 / BL6 mice with alcoholic LS , and in severely obese humans . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The ECM genes , alpha 1 type 1 collagen ( COL1A1 ) , plasminogen activator inhibitor 1 ( PAI 1 ) and fibronectin ( FN ) were assessed in wild type mesangial cells and stably transfected Smad 4 DN cell lines in the absence and presence of TGF beta . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Human peritoneal mesothelial cells ( HMC ) play a critical role in maintaining the intraperitoneal balance between fibrinolysis and coagulation by expressing the fibrinolytic enzyme tissue type plasminogen activator ( t PA ) and its specific inhibitor , plasminogen activator inhibitor 1 ( PAI 1 ) as well as the procoagulant protein , tissue factor . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) inhibits fibrinolysis by inhibiting plasminogen activators and has effects on leukocyte recruitment and matrix deposition . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Recent studies have shown that activity of plasminogen activator inhibitor 1 ( PAI 1 ) , a prothrombotic protein , may be increased in transplanted patients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The concentrations of lipids , lipoproteins , acute phase reactants , tHcy and atherothrombotic markers [ fibronectin , soluble vascular adhesion molecules 1 ( sVCAM 1 ) , soluble intercellular adhesion molecules 1 ( sICAM 1 ) , tissue plasminogen activator ( tPA ) , plasminogen activator inhibitor 1 ( PAI 1 ) , autoantibodies against oxidized LDL ( AuAb oxLDL ) ] were determined . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The normal fibrinolytic activity within the alveolar space is suppressed in fibrotic lung diseases in part because of increased levels of plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^ Studies with animals have shown that inhibition of the plasminogen system by PAI 1 increases the generation of pulmonary fibrosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
PURPOSE : To explain the conflicting reports about the influence of plasminogen activator inhibitor type ( PAI 1 ) on pathologic angiogenesis , such as occurs during the exudative form of age related macular degeneration . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
It also increased the secretion of plasminogen activator inhibitor 1 ( PAI 1 ) , a protein associated with matrix increase , by 3 . 2 fold . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) , a member of the serine protease inhibitor ( serpin ) superfamily , is the principal inhibitor of tPA and uPA in the fibrinolytic system . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) expression is directly regulated by clock genes , while angiotensin 2 modulates both PAI 1 and clock gene expression . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVES : To investigate the effect of rhein on endothelial plasminogen activator inhibitor 1 ( PAI 1 ) mRNA expression and protein production induced by transforming growth factor beta 1 ( TGFbeta 1 ) , and to explore the mechanism of the protective action of rhein on endothelial cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To measure the concentration of D dimer ( DD ) , tissue plasminogen activator ( t PA ) , plasminogen activator inhibitor 1 ( PAI 1 ) and plasminogen ( PLG ) activity in plasma and cerebrospinal fluid in patients with acute cerebral infarction and to investigate their clinical significance . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The concentrations in blood of plasminogen activator inhibitor 1 ( PAI 1 ) , an inhibitor of fibrinolysis and proteolysis , are elevated in obese and insulin resistant subjects , predispose them to the risk of thrombosis , and may accelerate atherogenesis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor type 1 ( PAI 1 ) is the major physiological regulator of plasminogen activation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In this study we investigated the effect of combined antioxidant treatment with vitamins C and E on endothelial function and plasma levels of plasminogen activator inhibitor ( PAI 1 ) , von Willebrand factor ( vWF ) , tissue plasminogen activator ( tPA ) and factor 7 ( fVII ) , in smokers . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This study examines the relationship between plasma Plasminogen Activator Inhibitor 1 ( PAI 1 ) activity and the PAI 1 4G / 5G polymorphism , and their association with the risk of myocardial infarction ( MI ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Urokinase and tissue type plasminogen activators and their type 1 inhibitor ( PAI 1 ) in gastric cancer ] . ^^^ The levels of urokinase ( uPA ) and tissue type ( tPA ) plasminogen activators and their type 1 inhibitor ( PAI 1 ) were determined by immunoassay in tumor cytosols and samples of histologically unaltered adjacent mucosa in gastric cancer patients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitors ( PAI 1 and PAI 2 ) were measured in parallel . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A random sample of 70 of the 112 cases had plasma levels of urokinase like plasminogen activator ( uPA ) , tissue type plasminogen activator ( tPA ) , plasminogen activator inhibitor 1 ( PAI 1 ) , macrophage inhibiting factor ( MIF ) , tumour growth factor beta 1 ( TGF beta 1 ) , homocysteine , and serum levels of IgA antibodies against Chlamydia pneumoniae ( IgA CP ) and Cotinine ( a nicotine metabolite ) measured . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Levels of the fibrinolytic protease inhibitor , plasminogen activator inhibitor 1 ( PAI 1 ) , are too low in bronchoalveolar lavage to address its prognostic significance . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In addition , elevated levels of urokinase , the urokinase receptor uPA R and its endogenous inhibitor plasminogen activator inhibitor ( PAI 1 ) , in combination with plasmin , play an important role in the pathogenesis of malignancy through its ability to mediate tumor cell growth , invasion and metastatic dissemination . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The tumor cell associated urokinase type plasminogen activator system , consisting of the serine protease uPA , its substrate plasminogen , its membrane bound receptor uPAR , as well as its inhibitors PAI 1 and PAI 2 , plays an important role in these pericellular processes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Clinically relevant molecules whose expression or structure is altered include the plasminogen activator ( uPA ) and its inhibitor PAI 1 ( plasminogen activator inhibitor type 1 ) , the cell cycle regulator cyclin E , epidermal growth factor ( EGF ) , the apoptosis inhibitor bcl 2 , the cell adhesion molecule E cadherin , and the multifunctional protein beta catenin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Since endothelial cells play a pivotal role in the regulation of hemostasis , we studied the effect of DV infection on the production of tissue plasminogen activator ( tPA ) and plasminogen activator inhibitor 1 ( PAI 1 ) in vitro using both primary isolated endothelial cells , human umbilical cord veins cells , and a human microvascular endothelial cell line . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) activity post myocardial infarction : the role of acute phase reactants , insulin like molecules and promoter ( 4G / 5G ) polymorphism in the PAI 1 gene . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : Previous observations have indicated that CO 2 insufflation increases peritoneal plasminogen activator inhibitor type 1 ( PAI 1 ) expression . ^^^ Samples of cell culture media were taken at 0 , 5 , and 24 h after exposure to measure media pH , PAI 1 , and tissue type plasminogen activator ( t PA ) protein release . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Analysis of tissue samples on reducing and non reducing polyacrylamide gels demonstrates complexes of tPA with plasminogen activator inhibitor 1 ( PAI 1 ) but not with neuroserpin , a tPA specific inhibitor concentrated in grey matter . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
PURPOSE : To quantify the ex vivo production of proangiogenic proteins ( vascular endothelial growth factor ( VEGF ) , basic fibroblast growth factor ( bFGF ) , urokinase type plasminogen activator ( u PA ) , tissue type plasminogen activator ( tPA ) ) and angiogenesis inhibitors ( plasminogen activator inhibitor type 1 ( PAI 1 ) and angiostatin ) from epithelial and stromal components of primary prostate cancer ( CaP ) and benign prostatic hyperplasia ( BPH ) cultures . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
YY 1 represses the induction of immediate early genes to TGF beta and BMP , such as the plasminogen activator inhibitor 1 gene ( PAI 1 ) and the inhibitor of differentiation / inhibitor of DNA binding 1 gene ( Id 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Real time PCR was used to demonstrate quantitatively that the levels of t PA transcripts were higher than those of its primary regulator [ ie , plasminogen activator inhibitor 1 ( PAI 1 ) ] in the Pa samples . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The interaction of the plasma protein vitronectin with plasminogen activator inhibitor 1 ( PAI 1 ) is central to human health . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We investigated how , during phorbol ester induced differentiation of HL 60 cells , the secreted TNFalpha modulated plasminogen activator inhibitor type 1 ( PAI 1 ) and gelatinase B ( MMP 9 ) syntheses , two proteins involved in pericellular proteolysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The expression of plasminogen activator inhibitor type 1 ( PAI 1 ) , fibronectin ( FN ) and angiotensin 2 type 1 receptor was examined utilizing Western blotting or immunohistochemistry . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Two polymorphisms , coagulation factor 13 ( FXIII ) Val34Leu and plasminogen activator inhibitor 1 ( PAI 1 ) 4G / 5G , interfere with fibrin cross linking and regulation of fibrinolysis and may therefore contribute to early pregnancy loss . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The aim of the study was to evaluate levels of several new atherosclerosis risk factors ( lipoprotein ( a ) ( Lp ( a ) ) , apolipoprotein A 1 ( Apo A 1 ) , apolipoprotein B ( Apo B ) , homocysteine ( Hcy ) , fibrinogen ( FB ) , tissue plasminogen activator ( t PA ) and tissue plasminogen activator inhibitor type 1 ( PAI 1 ) ) in children and adolescents with traditional risk factors ( obesity , hypertension , diabetes ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Blood was drawn for measurement of C reactive protein ( CRP ) , interleukin 6 ( IL 6 ) , plasminogen activator inhibitor 1 ( PAI 1 ) , malonyldialdehyde ( MDA ) , and total radical antioxidant parameter ( TRAP ) before and during the 4 hours after the test meal . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
No change in measures of fibrinolysis [ plasminogen activator inhibitor 1 ( PAI 1 ) , total tissue factor pathway inhibitor ( t TFPI ) , activated tissue factor pathway inhibitor ( TFPIa ) , d dimers ( DD ) , FSP and fibrinogen levels ] occurred . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We also measured plasma levels of soluble intercellular adhesion molecule ( sICAM ) , vascular adhesion molecule , von Willebrand factor , plasminogen activator inhibitor 1 ( PAI 1 ) antigen , and tissue plasminogen activator antigen . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) 1334G / A genetic polymorphism in colorectal cancer . ^^^ Plasminogen activator inhibitor 1 ( PAI 1 ) content in colorectal cancer tissue extracts may be of strong prognostic value : high levels of PAI 1 in tumours predict poor prognosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Two proteins , gelsolin and plasminogen activator inhibitor 1 ( PAI 1 ) , were tentatively identified by in gel tryptic digestion and mass fingerprint analysis by MALDI TOF mass spectrometry . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Results from two groups reveal a role for PAI 1 in promoting cycles of attachment and detachment of the cell from the extracellular matrix that is independent of its role as an enzymatic inhibitor of urokinase type plasminogen activator ( uPA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Vascular endothelial cells ( EC ) synthesize activators and inhibitors for fibrinolysis , tissue and urokinase plasminogen activators ( tPA and uPA ) and plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Prognostic and predictive value of the urokinase type plasminogen activator ( uPA ) and its inhibitors PAI 1 and PAI 2 in operable breast cancer . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
High levels of uPA and plasminogen activator inhibitor 1 ( PAI 1 ) correlate with poor prognosis in several cancers . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Analysis included systolic blood pressure , a glomerular histologic matrix score , and the glomerular mRNA and protein expression of the key fibrogen TGF beta 1 , the matrix protein fibronectin , and the protease inhibitor plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : The plasminogen activator inhibitor 1 ( PAI 1 ) spontaneously converts from an inhibitory into a latent form . ^^^ Specificity of PAI 1 is mainly determined by its reactive site ( Arg 346 Met347 ) , which interacts with serine residue of tissue type plasminogen activator ( tPA ) with concomitant formation of SDS stable complex . ^^^ Single site mutants within the Asp 355 Arg356 Pro 357 segment of PAI 1 yield guanidine activatable inhibitors ( a ) that can still form SDS stable complexes with tPA and urokinase plasminogen activator ( uPA ) , and ( b ) that have inhibition rate constants towards plasminogen activators which resemble those of the fibrosarcoma inhibitor . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To evaluate the role of plasminogen activator inhibitor 1 ( PAI 1 ) , urokinase plasminogen activator ( uPA ) , and tissue type plasminogen activator ( tPA ) in adhesion formation after laparoscopic surgery . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The plasminogen activator inhibitor 1 ( PAI 1 ) blocks the activation of plasmin ( ogen ) , an extracellular protease vital to cancer invasion . ^^^ PAI 1 is like the corresponding plasminogen activator uPA ( urokinase type plasminogen activator ) consistently expressed in human breast cancer . ^^^ In these tumors , the expression pattern of uPA and PAI 1 resembles that of human ductal breast cancer and plasminogen is required for efficient metastasis . ^^^ These results agree with the virtual lack of spontaneous phenotype in PAI 1 deficient mice and humans and may reflect that the plasminogen activation reaction is not rate limiting for tumor vascularization and metastasis , or that there is a functional redundancy between PAI 1 and other inhibitors of the uPA / plasmin system , masking the effect of PAI 1 deficiency . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
AIM / HYPOTHESIS : Plasminogen activator inhibitor 1 ( PAI 1 ) is a main regulator of the endogenous fibrinolytic system and modulates the thrombosis progression . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In order to describe potential hypofibrinolytic tendencies in young ( < 35 years ) polycystic ovary syndrome ( PCOS ) patients , we studied plasminogen activator inhibitor ( PAI 1 ) system components in women without laboratory evidence of hyperinsulinism or hyperandrogenism . ^^^ Mean fasting insulin levels were higher among PCOS women ( p < 0 . 01 ) and were strongly correlated with PAI 1 antigen ( Ag ) ( r = 0 . 46 ) , PAI 1 activity ( r = 0 . 43 ) , and tissue plasminogen activator ( t PA ) ( r = 0 . 5 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Endothelial function was assessed by flow mediated dilatation ( FMD ) of the brachial artery ; also assessed were the levels of von Willebrand factor ( vWF ) and plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Blood factors were D dimer , prothrombin 1 . 2 , tissue plasminogen activator ( t PA ) antigen , plasminogen activator inhibitor 1 ( PAI 1 ) , and inflammatory markers ( high sensitivity C reactive protein [ CRP ] , fibrinogen , and serum amyloid A [ SAA ] ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
MEASUREMENTS : Four measurements of fat : body mass index ( BMI , kg / m ( 2 ) ) , body fat percentage measured using a dual energy 10 ray absorptiometry ( DEXA ) scanner , waist / hip circumference ratio ( WHR ) , and intra abdominal adipose tissue area measured using computed tomography ( CT ) scanning , and eight metabolic risk factors : systolic and diastolic blood pressure , HbA ( 1c ) percentage , fasting concentrations of capillary whole blood glucose , high density lipoprotein ( HDL ) cholesterol , serum triglyceride , plasma plasminogen activator inhibitor 1 ( PAI 1 ) , and urinary albumin : creatinine excretion ratio . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In this study we investigated the production of interleukin 6 ( IL 6 ) , fibrinogen and plasminogen activator inhibitor 1 ( PAI 1 ) by hepatocytes after infection with CMV or C . pneumoniae . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
MEASUREMENTS : IMT of the common carotid artery , C reactive protein ( CRP ) , interleukin 6 ( IL 6 ) , fibrinogen , plasminogen activator inhibitor 1 ( PAI 1 ) activity and tissue plasminogen activator antigen ( tPA ag ) were measured . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Using primate materials obtained from rhesus monkeys , we have in this study investigated the expression and regulation of the plasminogen activators ( PAs ) and PA inhibitor type 1 ( PAI 1 ) during CL development and regression . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Of the `` new ' ' tumor biologic parameters , only the measurement of the urokinase type plasminogen activator ( uPA ) and its inhibitor ( PAI 1 ) in the primary tumor of node negative patients has been adequately validated and can therefore be recommended for clinical application . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
It is known that the plasminogen activator inhibitor 1 ( PAI 1 ) protein levels are increased in placentas of preeclamptic subjects . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : Fibrinolysis was assessed by measurement of tissue plasminogen activator ( t PA ) and tissue plasminogen activator inhibitor ( PAI 1 ) concentrations , whereas activation of thrombinogenesis was detected by F 1 + 2 prothrombin fragment concentration . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Activity of plasma plasminogen activator inhibitor 1 ( PAI 1 ) , the major physiologic inhibitor of proteo ( fibrino ) lysis , in OLETF was higher than that in LETO at 40 and 60 weeks , suggesting that increase of PAI 1 may downregulate compensatory adaptive capillary network remodeling by inhibiting proteolysis and angiogenesis in the cardiac interstitium . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is the principal inhibitor of urokinase type plasminogen activator ( uPA ) and tissue type plasminogen activator ( tPA ) , and as such is thought to play an important role in the regulation of extracellular matrix remodeling . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Elevated plasma plasminogen activator inhibitor 1 ( PAI 1 ) level is a core feature of insulin resistance syndrome ( IRS ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma samples were analyzed for the concentration of C reactive protein ( CRP ) , fibrinogen , d dimer , plasminogen activator inhibitor type 1 ( PAI 1 ) antigen and activity , tissue type plasminogen activator ( t PA ) antigen and activity , factor 7 ( FVII ) antigen , FVII coagulant activity ( FVII : C ) and activated FVII ( FVIIa ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is the most important physiological inhibitor of plasminogen activators . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Finally , gene expression of plasminogen activator inhibitor 1 ( PAI 1 ) and TGF beta , two powerful fibrogenic factors , was evaluated in FXa , trypsin , and PAR 2 activating peptide stimulated human proximal tubular cells by Northern blot . ^^^ In addition , incubation of both cell lines with trypsin , FXa , or PAR 2 activating peptide caused a marked upregulation of PAI 1 gene expression that was not counterbalanced by an increased expression of plasminogen activators . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Mice with homozygous deletion of the plasminogen activator inhibitor 1 gene ( PAI 1 ( / ) ) are relatively protected from bleomycin induced pulmonary fibrosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Independence of growth factor induced plasminogen activator inhibitor type 1 ( PAI 1 ) expression from the 4G / 5G polymorphism of the PAI 1 gene . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The monoclonal antibody MA 33B8 , directed against the serpin plasminogen activator inhibitor 1 ( PAI 1 ) , has unique functional properties as it induces acceleration of the active to latent transition ( Verhamme 1 et al . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : A few studies have suggested that von Willebrand factor ( vWF ) or plasminogen activator inhibitor 1 ( PAI 1 ) can be associated with outcomes of acute coronary syndromes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The mRNA expressions of preproendothelin 1 ( prepro ET 1 ) , type 1 collagen ( ColI ) , transforming growth factor beta 1 ( TGF beta 1 ) , tissue inhibitors of metalloproteinase 1 ( TIMP 1 ) and type 1 plasminogen activator inhibitor ( PAI 1 ) were detected semiquantitatively with reverse transcription polymerase chain reaction ( RT PCR ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The serpin plasminogen activator inhibitor 1 ( PAI 1 ) is a potential target for anti thrombotic and anti cancer therapy . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In contrast , plasminogen activator inhibitor 1 ( PAI 1 ) expression was strong in the tumor stroma , along with PAI 2 and PAI 3 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Whereas a low PGE ( 1 ) concentration decreased CsA induced production of fibronectin ( FN ) and plasminogen activator inhibitor type 1 ( PAI 1 ) , a higher PGE 1 concentration did not change FN production , but further increased PAI 1 production . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To this end , 240 Swedish individuals without cardiovascular disease were typed for the eight SNPs and an Alu insertion polymorphism at the PLAT locus , as well as for a polymorphism in the plasminogen activator inhibitor type 1 ( PAI 1 ) promoter ( PAI 1 675 4G > 5G ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Type 1 plasminogen activator inhibitor ( PAI 1 ) is the primary inhibitor of tissue type plasminogen activator ( tPA ) and urokinase type plasminogen activator ( uPA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In fibrotic renal disease , elevated TGF beta and angiotensin 2 lead to increased plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^ PAI 1 appears to reduce glomerular mesangial matrix turnover by inhibiting plasminogen activators , thereby decreasing plasmin generation and plasmin mediated matrix degradation . ^^^ We hypothesized that therapy with a mutant human PAI 1 ( PAI 1R ) that binds to matrix vitronectin but does not inhibit plasminogen activators , would enhance plasmin generation , increase matrix turnover , and decrease matrix accumulation in experimental glomerulonephritis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A delicate balance exists between ECM synthesis and degradation such that interruption of the corresponding pathways results in increased plasminogen activator inhibitor 1 ( PAI 1 ) , pathological matrix accumulation , and glomerulosclerosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To measure the circulating levels of thrombomodulin ( TM ) and plasminogen activator inhibitor type 1 ( PAI 1 ) in women with pregnancy induced hypertension ( PIH ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) , which has been implicated in oviduct function during the preimplantation period , also had a significant rhythm of expression ( 2 . 5 fold amplitude ) , peaking at the same time as the other clock controlled genes , DBP and Rev erb alpha . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Constitutive shedding of IL 8 in this form was increased in the presence of a neutralizing Ab to plasminogen activator inhibitor 1 ( PAI 1 ) , indicating a role for endothelial plasminogen activator in the shedding of IL 8 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In this study , paraffin embedded material from 84 human pituitary adenomas ( acromegaly n=18 , Cushing ' s disease n=21 , prolactinoma n=18 , thyroid stimulating hormone secreting adenoma n=1 , nonsecreting adenoma n=26 ) and 9 nontumourous anterior pituitary lobes ( obtained from patients with prostate cancer ) was immunohistochemically analysed for expression of MMP 2 , MMP 9 , tissue inhibitor of metalloproteinases 2 ( TIMP 2 ) , urokinase type plasminogen activator ( uPA ) , uPA receptor ( uPAR ) , tissue type plasminogen activator ( tPA ) , plasminogen activator inhibitor 1 ( PAI 1 ) , and interleukin 6 ( IL 6 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To study the effect of nuclear transcription factor AP 1 on tumor necrosis factor alpha ( TNF alpha ) or minimal modified low density lipoprotein ( mmLDL ) induced expression of plasminogen activator inhibitor 1 ( PAI 1 ) in human vascular endothelial cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OJECTIVE : To investigate the effect of peroxisome proliferator activated receptors ( PPARs ) activators on plasminogen activator inhibitor type 1 ( PAI 1 ) expression in human umbilical vein endothelial cells and the possible mechanism . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In vitro , TGF beta 1 protects neurons against excitotoxicity by inhibiting the t PA potentiated NMDA induced neuronal death through a mechanism involving the up regulation of the type 1 plasminogen activator inhibitor ( PAI 1 ) in astrocytes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : We determined the plasma prothrombin time ( PT ) , activated partial thromplastin time ( APTT ) , activity of tissue type plasminogen activator ( t PA ) , activity of plasminogen activator inhibitor 1 ( PAI 1 ) and fibrinogen ( Fg ) level of 24 endogenous hyper triglyceridemic patients and 34 healthy controls , and observed their relationship to serum lipids and apolipoproteins . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A pan specific antibody to TGF beta most effectively blocked plasminogen activator inhibitor type 1 ( PAI 1 ) synthesis by epithelial cells under oxidative stress . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : Patients with Type 2 diabetes mellitus have increased levels of hemostatic risk variables for cardiovascular disease , such as fibrinogen , von Willebrand factor ( VWF ) , factor ( F ) VIIa , d dimer and plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Elevated circulating plasminogen activator inhibitor 1 ( PAI 1 ) may increase risk of cardiovascular disease ( CVD ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
VN stabilizes the inhibitory confirmation of plasminogen activation inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Hypoandrogenemia in men and hyperandrogenemia in women are associated with increased risk of coronary artery disease but also with visceral obesity , insulin resistance , low high density lipoprotein ( HDL ) cholesterol , elevated triglycerides , low density lipoprotein ( LDL ) cholesterol and plasminogen activator inhibitor ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To date , the factors capable of regulating the coordinate expression of the urokinase type plasminogen activator ( uPA ) and its endogenous inhibitor , plasminogen activator inhibitor ( PAI 1 ) , at the maternal fetal interface remain poorly characterized . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The second multicenter study enrolling 88 patients demonstrated that in the survivors , the plasma level of mediators such as TNF alpha , IL 6 , IL 10 and plasminogen activator inhibitor 1 ( PAI 1 ) was significantly decreased following treatment with PMX . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
High plasma levels or activities of fibrinogen , factor 7 , factor 8 , von Willebrand factor ( vWF ) , soluble thrombomodulin , tissue plasminogen activator ( tPA ) and plasminogen activator inhibitor 1 ( PAI 1 ) are thought to be associated with increased morbidity and mortality related to cardiovascular disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fibronectin ( FN ) and plasminogen activator inhibitor 1 ( PAI 1 ) were detected by ELISA method . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : The biochemical markers ' levels in plasma for platelet activity [ soluble P selectin ( GMP 140 ) ] , states of thrombin generation [ antithrombin 3 ( AT 3 ) and protein C ( PC ) ] , fibrinolysis [ D dimer ( DD ) , plasminogen activator inhibitor 1 ( PAI 1 ) , tissue plasminogen activator ( t PA ) and FDP ] and von Willebrand factor ( vWF ) were determined from blood specimens obtained from the femoral veins and arteries and the right and left atria of 43 consecutive patients ( 20 with atrial fibrillation and 23 with sinus rhythm ) with mitral stenosis ( MS ) , undergoing percutaneous mitral valvuloplasty . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
DESIGN AND METHODS : We studied the effects of ATRA on procoagulant ( i . e . tissue factor , TF ) , fibrinolytic ( i . e . tissue plasminogen activator and inhibitor , t PA and PAI 1 ) and anticoagulant ( i . e . thrombomodulin , TM ) properties of HMEC 1 , compared to HUVEC . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We examined effects of pitavastatin ( NK 104 ) , a relatively novel and long acting statin , on expression of tissue factor ( TF ) in human monocytes ( U 937 ) , plasminogen activator inhibitor 1 ( PAI 1 ) , and tissue type plasminogen activator ( t PA ) in human aortic smooth muscle cells ( SMC ) and human umbilical vein endothelial cells ( HUVEC ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the present study , we investigated the impact of HA on the synthesis of tissue type plasminogen activator ( t PA ) and its inhibitor , plasminogen activator inhibitor type 1 ( PAI 1 ) in cultured human peritoneal mesothelial cells ( MC ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : The aim of this study was to investigate the effect of insulin and an insulin sensitizing agent , rosiglitazone ( RSG ) , on the production of plasminogen activator inhibitor 1 ( PAI 1 ) in isolated subcutaneous abdominal adipocytes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To test this hypothesis , we compared allele frequencies between Quechua and more closely related lowlanders ( Maya ) at loci in the genes encoding beta fibrinogen ( FGB ) , factors 5 ( F 5 ) , 7 ( F 7 ) and 13 ( F 13 ) , alpha 2 integrin ( ITGA 2 ) and plasminogen activator inhibitor type 1 ( PAI 1 ; SERPINE 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVES : To investigate the prolonged effect of HRT on the fibrinolytic system and to determine whether two common polymorphisms in the plasminogen activator inhibitor 1 ( PAI 1 ) and tissue type plasminogen activator ( t PA ) genes modulate this effect . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
IGF 2 induced migration was abolished by insulin like growth factor binding protein 6 ( IGFBP 6 ) ( P < 0 . 01 ) , a relatively specific inhibitor of IGF 2 , and by plasminogen activator inhibitor type 1 ( PAI 1 ) ( P < 0 . 05 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma levels of plasminogen activator inhibitor 1 ( PAI 1 ) decreased rapidly in both circuits but were higher in the control circuits at each time point studied . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have recently described the novel autoantigen plasminogen activator inhibitor ( PAI 1 ) in systemic lupus erythematosus ( SLE ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue specimens from eight patients with failing or failed infra inguinal vein bypasses and three specimens from normal veins were harvested to study urokinase type plasminogen activator ( u PA ) , tissue type plasminogen activator ( t PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) by in situ hybridization and immunohistochemistry . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fasting plasma glucose ( FPG ) , fasting plasma insulin ( FPI ) , glycosylated hemoglobin , homeostasis model assessment ( HOMA ) index , systolic blood pressure ( SBP ) , diastolic blood pressure ( DBP ) , total cholesterol ( TC ) , low density lipoprotein cholesterol ( LDL C ) , high density lipoprotein cholesterol , triglycerides , lipoprotein ( a ) ( Lp [ a ] ) , plasminogen activator inhibitor 1 ( PAI 1 ) , homocysteine , body mass index ( BMI ) , and albumin excretion rate ( AER ) were assessed . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Synthesis and biological evaluation of menthol based derivatives as inhibitors of plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We investigated the relationship between diabetic retinopathy ( DR ) and three polymorphisms , C ( 106 ) T in the aldose reductase ( ALR 2 ) gene , 4G / 5G in the plasminogen activator inhibitor 1 ( PAI 1 ) gene and C677T in the methylenetetrahydrofolate reductase ( MTHFR ) gene , in 210 Euro Brazilian type 2 diabetic patients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Effect on severity has repeatedly been reported for FcgammaRIIa and plasminogen activator inhibitor type 1 ( PAI 1 ) polymorphisms . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Patients exhibited hypofibrinolysis and higher plasminogen activator inhibitor 1 ( PAI 1 ) levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The Insulin Resistance Atherosclerosis Study found that insulin resistance , as determined by a frequently sampled glucose tolerance test , is significantly related to higher CRP levels , higher fibrinogen , and higher plasminogen activator inhibitor 1 ( PAI 1 ) levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Increased expression of plasminogen activator inhibitor 1 ( PAI 1 ) in coronary vessels and the perivascular area was evident in diabetic hearts . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Increased plasma plasminogen activator inhibitor 1 ( PAI 1 ) has been implicated in the development of vascular disease . ^^^ While tissue plasminogen activator ( tPA ) and adipsin , an adipocyte derived protease , were unaffected by LIP , changes in soluble vascular cell adhesion molecule 1 ( sVCAM 1 ) were significantly correlated ( p = 0 . 02 ) with those seen for PAI 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In this report we present an extension of the pooled analysis of the prognostic impact of urokinase type plasminogen activator ( uPA ) and its inhibitor PAI 1 in breast cancer patients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Hematological parameters including platelet count , D dimer , Plasminogen activator inhibitor 1 ( PAI 1 ) and fibrinogen degradation products ( FDP ) were checked respectively at the point of baseline , 24 hours , 48 hours and 24 hours post IABP counterpulsation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The 4G allele of common 4G / 5G polymorphism in the promoter of the plasminogen activator inhibitor 1 ( PAI 1 ) gene is associated with increased PAI 1 transcription and has been proposed as a candidate genetic risk factor for thrombotic diseases . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Genotyping of the beta fibrinogen 455 G / A , glycoprotein ( GP ) IIIa PlA1 / PlA2 , plasminogen activator inhibitor 1 ( PAI 1 ) 4G / 5G , factor 5 Leiden 1691 G / A , tumour necrosis factor alpha ( TNFalpha ) 238 G / A , TNFalpha 308 G / A , interleukin ( IL ) 1alpha 889 C / T , IL 1beta 511 C / T , methylenetetrahydrofolate reductase ( MTHFR ) 677 C / T and endothelial nitric oxide synthase ( eNOS ) 4 b / a gene polymorphisms was performed by PCR and restriction fragment length polymorphism based techniques . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) acts as the major inhibitor of fibrinolysis by inhibiting tissue type and urokinase type plasminogen activators . ^^^ The purified protein yielded a single , 43kDa protein band upon SDS polyacrylamide gel electrophoresis , and it efficiently inhibited tissue type and urokinase type plasminogen activators similar to PAI 1 from natural sources . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
PURPOSE : Urokinase type plasminogen activator ( uPA ) , plasminogen activator inhibitor ( PAI 1 ) , and uPA receptor ( uPAR ) are prognostic factors in various cancer types , especially breast cancer . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The serine protease urokinase type plasminogen activator ( uPA ) , its inhibitor PAI 1 , and its cellular receptor uPA R ( CD 87 ) are of crucial importance during cellular invasion and migration , required for a variety of physio and pathophysiological processes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Transforming growth factor beta 1 ( TGF beta 1 ) promotes tissue fibrosis by upregulating genes encoding extracellular matrix proteins and by increasing the synthesis of plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
As the most prominent example for cholesterol dependent genes , we identified PAI 1 ( plasminogen activator inhibitor 1 ) , a protein regarded as a risk factor for atherosclerosis . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
While data concerning a number of parameters remain contradictory , high levels of type 1 plasminogen activator inhibitor ( PAI 1 ) and hyperhomocysteinemia appear to play a significant role in the pathogenesis of this disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is a typical member of the serpin family that kinetically traps its target proteinase as a covalent complex by distortion of the proteinase domain . ^^^ Incorporation of the fluorescently silent 4 fluorotryptophan analog into PAI 1 permitted us to observe changes in the intrinsic tryptophan fluorescence of two chain tissue type plasminogen activator ( tPA ) and the proteinase domain of tPA during the inhibition reaction . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Type 2 diabetes is characterised by insulin resistance in association with clustering of atherothrombotic risk factors ( dysglycaemia , hyperinsulinaemia , hypertension , raised triglyceride , low HDL cholesterol and increased levels of plasminogen activator inhibitor 1 ( PAI 1 ) and clotting factor 7 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Obstructed kidneys from beta 6 ( / ) mice showed less injury than obstructed kidneys from wild type ( WT ) mice , associated with lower collagen 1 , collagen 3 , plasminogen activator inhibitor ( PAI 1 ) , and TGF beta 1 mRNA levels and lower collagen content . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
DESIGN AND METHODS : A group of 59 women with gestational hypertension were prospectively tested between 24 and 26 weeks of gestation for : ( 1 ) DNA analysis to search for gene mutations of Factor 5 Leiden , prothrombin , methylenetetrahydrofolate reductase and plasminogen activator inhibitor type 1 ( PAI 1 ) polymorphism ; ( 2 ) maternal serum concentrations of homocysteine and PAI 1 , activated protein resistance and Factor 2 : C activity levels ; ( 3 ) mean uterine arterial resistance index ( RI ) by Doppler velocimetry ; and ( 4 ) history of hypertensive disorders in relatives ( the mother and / or the father ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS AND RESULTS : The mRNA and protein expression of tissue factor ( TF ) and plasminogen activator inhibitor 1 ( PAI 1 ) induced by angiotensin 2 ( Ang 2 ) were evaluated in cultured rat aortic endothelial cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Hyperthyroid ( n=10 ) , hypothyroid ( n=10 ) and subclinical hypothyroid ( n=10 ) patients and control cases ( n=16 ) were evaluated for free and total tissue factor pathway inhibitor ( tTFPI ) , plasminogen activator inhibitor 1 ( PAI 1 ) and tissue plasminogen activator ( tPA ) levels in disease and euthyroid states . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The 2 putative vasoactive epitopes of tPA are regulated by the plasminogen activator inhibitor 1 ( PAI 1 ) and by a PAI 1 derived hexapeptide that binds tPA . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : This study was undertaken to investigate the origin and pathophysiological importance of plasminogen activator inhibitor ( PAI 1 ) in atherosclerosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We determined the changes in tPA and plasminogen activator inhibitor ( PAI 1 ) expression in adult rat brain after transient middle cerebral artery ( MCA ) occlusion . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In vitro , TGF beta 1 protects neurons against excitotoxicity by inhibiting the t PA potentiated NMDA induced neuronal death through a mechanism involving the up regulation of the type 1 plasminogen activator inhibitor ( PAI 1 ) in astrocytes 4 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To examine the effect of vitamin C on forearm vasodilatory response to reactive hyperemia and on plasma level of plasminogen activator inhibitor 1 ( PAI 1 ) , von Willebrand factor ( vWF ) , tissue plasminogen activator ( tPA ) , antithrombin 3 ( ATIII ) , proteins C and S , and factors 5 ( fV ) and 7 ( fVII ) in patients with both type 2 diabetes and CAD . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Impairment of the fibrinolytic system , mostly due to elevated plasma levels of plasminogen activator inhibitor 1 ( PAI 1 ) , is often associated with metabolic disorders such as diabetes mellitus and insulin resistance syndrome . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is suggested to be involved in the pathophysiology of early thrombosis and late restenosis after percutaneous transluminal angioplasty ( PTA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Substantial evidence exists which implicates the urokinase plasminogen activator system [ urokinase plasminogen activator ( uPA ) , urokinase plasminogen activator receptor ( uPAR ) and plasminogen activator inhibitor 1 ( PAI 1 ) ] in the neo vascularization , invasion and metastasis of many solid tumors . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : The plasma levels of tissue plasminogen activator ( tPA ) and plasminogen activator inhibitor 1 ( PAI 1 ) were measured before and after treatment in the captopril group ( group A , 35 cases ) and the routine group ( group B , 37 cases ) of patients with HAPE , while 20 healthy volunteers served as the control ( group C ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : The mRNA steady state level of a large spectrum of proteolytic enzymes ( matrix metalloproteinases : MMP 1 , 2 , 3 , 8 , 9 , 11 , 12 , 13 , 14 ; urokinase plasminogen activator : u PA ) , their physiological inhibitors ( tissue inhibitors of MMPs : TIMP 1 , 2 , 3 ; plasminogen activator inhibitor : PAI 1 ) and that of structural matrix proteins ( collagens type 1 and 3 , decorin , elastin , fibrillins 1 and 2 ) was determined by RT PCR made quantitative by using a synthetic RNA as internal standard in each reaction mixture . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In two different mouse models of Alzheimer ' s disease , chronically elevated Abeta peptide in the brain correlates with the upregulation of plasminogen activator inhibitor 1 ( PAI 1 ) and inhibition of the tPA plasmin system . ^^^ In addition , Abeta injected into the hippocampus of mice lacking either tPA or plasminogen persists , inducing PAI 1 expression and causing activation of microglial cells and neuronal damage . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Blood was collected immediately before and after each test and analyzed for von Willebrand Factor antigen ( vWF : ag ) , tissue plasminogen activator ( tPA ) antigen , and plasminogen activator inhibitor 1 ( PAI 1 ) activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : Tumor expression of urokinase type plasminogen activator ( uPA ) , plasminogen activator inhibitor 1 ( PAI 1 ) , and uPA receptor ( uPAR ) are breast cancer prognostic factors . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This study utilized mesangial cells isolated from mice with gene deletions for tPA , uPA , and plasminogen activator inhibitor 1 ( PAI 1 ) to further delineate the role of the PA / plasminogen / plasmin system in ECM accumulation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Ethyl pyruvate decreased plasma tumor necrosis factor alpha ( TNF alpha ) , and kidney mRNA for TNF alpha , tissue factor , and plasminogen activator inhibitor 1 ( PAI 1 ) , and increased mRNA for urokinase like plasminogen activator . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor type 1 ( PAI 1 ) plays a role in the development of atherosclerosis in diabetic patients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In a retrospective study of 488 women with primary breast cancer , after a median follow up of 10 years , we sought interactions between disease free survival ( DFS ) and overall survival ( OS ) and tumor antigen levels of two components of the plasminogen system , urokinase type plasminogen activator ( uPA ) and its inhibitor PAI 1 , and the transmembrane growth factor receptor c erbB 2 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Adipokines such as Plasminogen activator inhibitor 1 ( PAI 1 ) , interleukin ( IL ) 8 , and tumor necrosis factor ( TNF ) alpha are elevated in patients with obesity , insulin resistance , and type 2 diabetes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Interestingly , urokinase plasminogen activator ( uPA ) and and PA inhibitor 1 ( PAI 1 ) levels were not significantly affected by HA of increasing MW ; however , the PAI 1 to uPA ratio showed a slight , yet nonsignificant increase . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
It is strongly regulated by the plasma concentration of an inhibitor called plasminogen activator inhibitor 1 ( PAI 1 ) which synthesis strongly increases in obese insulin resistant and diabetic patients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We measured the hemostatic factors , fibrinogen , factor VIIc , tissue plasminogen activator ( t PA ) , and plasminogen activator inhibitor type 1 ( PAI 1 ) , as well as glucose and insulin to calculate insulin resistance . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To ensure accurate representation of differential gene expression , Northern blot analyses using total RNA from 16 samples of non pregnant and pregnant myometrium were used to examine mRNA levels for four of the genes that were differentially expressed by microarray analysis , namely plasminogen activator inhibitor type 1 ( PAI 1 ) , milk fat globule EGF factor 8 protein ( MFGE 8 ) , secreted frizzled related protein 4 ( sFRP 4 ) and estrogen receptor alpha ( ERalpha ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : Twenty PVR , PDR or pucker membranes were examined to identify the cells with cell specific markers and to detect the expression of urokinase ( uPA ) , tissue type plasminogen activator ( tPA ) or plasminogen activator inhibitor 1 ( PAI 1 ) by in situ hybridization and by immunohistochemistry . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The tumor level of plasminogen activator inhibitor 1 ( PAI 1 ) is an informative biochemical marker of a poor prognosis in several cancer types . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The diabetic milieu elevates the production of the plasminogen activator inhibitor type 1 ( PAI 1 ) and also increases the proliferation of vascular endothelial cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS AND RESULTS : In 1522 individuals in the Insulin Resistance Atherosclerosis Study , anthropometric measures and measures of lipids , apoB , C reactive protein , fibrinogen , plasminogen activator inhibitor 1 ( PAI 1 ) , fasting and postglucose load glucose and insulin concentrations , and carotid artery intima media thickness ( IMT ) were taken and insulin sensitivity was determined by frequently sampled intravenous glucose tolerance test . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : Angiotensin 2 ( Ang 2 ) increases levels of aldosterone and plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We investigated the response of human skin fibroblasts to elevated glucose level ( 11 . 0 and 30 . 0 mM ) in terms of : ( 1 ) the expression and secretion of fibronectin ( FN ) and plasminogen activator inhibitor 1 ( PAI 1 ) ; ( 2 ) the accumulation of hyaluronic acid ( HA ) in pericellular matrix and in the conditioned medium ; ( 3 ) TGFbeta 1 expression , secretion and activation ; ( 4 ) TSP 1 expression and secretion . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fibrinolysis is tightly regulated by plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : To elucidate the role of some haemostatic gene polymorphisms and environmental factors , we studied fibrinogen ( Fb ) , plasminogen activator inhibitor 1 ( PAI 1 ) , and tissue plasminogen activator ( t PA ) levels with respect to Fb G455A and PAI 1 4G / 5G gene polymorphisms in smokers and nonsmokers with essential hypertension . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have found that T beta 4 upregulates the expression of plasminogen activator inhibitor 1 ( PAI 1 ) in endothelial cells measured both at the level of mRNA and protein synthesis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the present review the dates about association of genetic variants of a plasminogen activator inhibitor type 1 ( PAI 1 ) and tissue plasminogen activator ( tPA ) with ischemic heart disease and atherosclerosis of other localization are toted . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The presence of plasminogen activator inhibitors ( PAI 1 , PAI 2 , PAI 3 ) was also documented in the cancer cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The binding of plasminogen activator inhibitor 1 ( PAI 1 ) to serine proteinases , such as tissue type plasminogen activator ( tPA ) and urokinase type plasminogen activator ( uPA ) , is mediated by the exosite interactions between the surface exposed variable region 1 , or 37 loop , of the proteinase and the distal reactive center loop ( RCL ) of PAI 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The degradation of basement membranes by tumor cells involves secretion and activation of proteinases , such as matrix metalloproteinases ( MMPs ) and the plasminogen activation system ( uPA , tPA , PAI 1 ) , and results from an imbalance between their inhibitors and activators , controlled by various growth factors or cytokines . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : Plasminogen activator inhibitor 1 ( PAI 1 ) has been proposed as a candidate risk factor for restenosis after coronary artery stenting . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Effects of short term exercise training on plasminogen activator inhibitor ( PAI 1 ) . ^^^ PURPOSE : To observe the effects of exercise training on plasminogen activator inhibitor , type 1 ( PAI 1 ) , tissue plasminogen activator ( tPA ) , and associated metabolic variables in sedentary men and women . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Impaired insulin sensitivity patients had significantly higher levels of C reactive protein ( CRP ) , TGF beta 1 , plasminogen activator inhibitor 1 ( PAI 1 ) , activated factor 7 ( VIIa ) , and prothrombin fragment 1 + 2 ( F 1 + 2 ) compared with either control subjects or NIS patients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Several new factors that may better describe tumour behaviour , like proliferation rate ( determined by thymidine labelling index , S phase fraction , mitotic index , or Ki 67 ) , presence of disseminated tumour cells , as well as expression of invasion factors ( urokinase type plasminogen activator uPA and its inhibitor PAI 1 ) and of cell cycle genes ( cyclin E ) , as well as gene expression patterns ( ' genomic profiling ' ) are currently discussed as future methods of risk assessment and also as tools for prediction of response to specific therapy modalities . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Urokinase type plasminogen activator ( uPA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) were determined using ELISA in colorectal carcinoma WiDr , HT 29 and HT 29d cell lines with different metastatic potentials . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : Immunoblot and zymography were used to detect the presence or absence of MMP 1 and 7 , tissue inhibitor of metalloproteinase 1 and 2 ( TIMP 1 , TIMP 2 ) , plasminogen activator activity and plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^ RESULTS : We detected MMP 7 , urokinase plasminogen activator ( uPA ) and PAI 1 in both Matrigels , TIMP 2 was detected only in regular Matrigel and no MMP 1 or TIMP 1 was detected in either matrix . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Molecular research into the invasiveness of HCC identified some factors positively related to invasiveness , P 16 and P 53 mutation , H ras , c cerbB 2 , mdm 2 , transforming growth factor ( TGF ) , epidermal growth factor receptor ( EGF R ) , matrix metalloproteinase 2 ( MMP 2 ) , urokinasetype plasminogen activator ( uPA ) , its receptor ( uPA R ) and inhibitor ( PAI 1 ) , intercellular adhesion molecule 1 ( ICAM 1 ) , vascular endothelial growth factor ( VEGF ) , platelet derived endothelial cell growth factor ( PD ECGF ) , and basic fibroblast growth factor ( bFGF ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma t PA antigen was correlated with plasminogen activator inhibitor type 1 ( PAI 1 ) activity when the participants consumed all three diets ( Rs = 0 . 78 , P < 0 . 01 ; Rs = 0 . 76 , P < 0 . 01 ; Rs = 0 . 66 , P = 0 . 03 ; on the HSAFA , the LSAFA and the HUFA diet , respectively ) , although the diets did not affect the PAI 1 levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Influence of TGF beta 2 on expression of MMP 2 , MMP 9 , membrane type 1 MMP ( MT 1 MMP ) and plasminogen activator inhibitor 1 ( PAI 1 ) was examined using RT PCR , Northern Blot , Western Blot and zymography . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the present study , we observed that the plasminogen activator inhibitor 1 ( PAI 1 ) levels in serum and its gene expression in adipose tissue were up regulated in aged OLETF rats , model animals of obese type 2 diabetes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We hypothesized that elevated plasminogen activator inhibitor 1 ( PAI 1 ) activity could neutralize infused t PA or urokinase , resulting in lysis failure . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Laboratory evaluation indicated excessive fibrinolysis with low plasminogen , low alpha 2 antiplasmin , undetectable plasminogen activator inhibitor type 1 ( PAI 1 ) activity , high tissue plasminogen activator ( t PA ) activity and high t PA antigen . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To explore the effects of arsenic trioxide ( As2O3 ) on tissue factor ( TF ) , plasminogen activator inhibitor 1 ( PAI 1 ) and PAI 2 expression in NB 4 , HL 60 and THP 1 cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have previously shown that levels of plasminogen activator inhibitor 1 ( PAI 1 ) , the major physiologic inhibitor of fibrinolysis , are increased with atherogenic metabolic derangement . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is the major physiological inhibitor of tissue plasminogen activator ( tPA ) and is elevated in diseases of vascular remodeling . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
MATERIALS AND METHODS : In a prospective study , prothrombin fragment 1 and 2 ( F1 . 2 ) , thrombin antithrombin complex ( TAT ) , antithrombin , D dimer , plasmin alpha ( 2 ) antiplasmin complex ( PAP ) and plasminogen activator inhibitor 1 ( PAI 1 ) were measured in 20 patients with Crohn ' s disease ( CD ) , 18 with ulcerative colitis ( UC ) , and 19 with giant cell arteritis during active and inactive disease , as well as in 51 controls without inflammation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the patients and in 25 control subjects , plasma levels of tissue type plasminogen activator , plasminogen activator inhibitor ( PAI 1 ) , D dimer , prothrombin fragment 1 + 2 ( F 1 + 2 ) , total cholesterol , triglycerides and fibrinogen had been measured . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A number of studies have identified a role for plasminogen activator inhibitor 1 ( PAI 1 ) in regulating angiogenesis , although results from these investigations have been controversial . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
These include tumor necrosis factor ( TNF alpha ) , plasminogen activator inhibitor type 1 ( PAI 1 ) , leptin , resistine and adiponectin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To investigate the impact of 30 minute walking exercise at 70 % VO2max on tissue plasminogen activator ( t PA ) Ag and plasminogen activator inhibitor type 1 ( PAI 1 ) Ag in obese sedentary males . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Physiologic and histologic changes were studied in addition to TGF beta 1 mRNA and protein expressions , and mRNA expression of plasminogen activator inhibitor 1 ( PAI 1 ) and the extracellular matrix ( ECM ) proteins biglycan and types 1 and 4 collagen . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Although the potential role of plasminogen activator inhibitor 1 ( PAI 1 ) in the development of coronary artery disease is strongly supported by its biological characteristics , results of clinical studies remain controversial . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In order to investigate the physiological regulation of human plasminogen activator inhibitor type 1 ( hPAI 1 ) expression in vivo compared to murine PAI 1 ( mPAI 1 ) and to test the physiological relevance of regulatory mechanisms described in vitro , we generated transgenic mice expressing enhanced green fluorescent protein ( EGFP ) driven by the proximal 2 . 9 kb of the hPAI 1 promoter . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND AND PURPOSE : Plasminogen activator inhibitor type 1 ( PAI 1 ) is the main inhibitor of fibrinolysis , and high levels may increase the risk of cardiovascular disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The type 1 plasminogen activator inhibitor ( PAI 1 ) , the primary inhibitor of both tissue type and urokinase type plasminogen activators ( t PA , u PA ) , is the primary regulator of plasminogen activation and possibly of extracellular proteolysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
RESULTS : No significant changes versus baseline and placebo were found in the tE ( 2 ) group , except for plasminogen activator inhibitor type 1 ( PAI 1 ) in cycle 13 ( 32 . 4 % , P= . 01 ) . ^^^ In the oE ( 2 ) group , significant percentage changes from baseline versus placebo in cycle 13 were found in fibrinogen , 5 . 4 % ( P < . 05 ) ; factor 7 , 7 . 3 % ( P < . 05 ) ; thrombin antithrombin 3 complexes , 13 . 3 % ( P < . 05 ) ; tissue type plasminogen activator ( t PA ) , 17 . 3 % ( P < . 001 ) ; and PAI 1 , 54 . 3 % ( P < . 001 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We compared plasma levels of interleukin ( IL ) 6 , C reactive protein ( CRP ) , IL 1beta , IL 11 , tissue plasminogen activator ( tPA ) activity , plasminogen activator inhibitor 1 ( PAI 1 ) activity , and global fibrinolytic capacity ( GFC ) in patients with MM ( n = 66 ) and in control subjects ( n = 18 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
HGF abrogated TGF beta 1 induced production of the profibrotic tissue inhibitor of metalloproteinase 2 ( TIMP 2 ) and plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Supernatant was removed for analysis at 0 , 24 , 48 , and 72 hours after gas incubation and analyzed for plasminogen activator activity , total tissue plasminogen activator ( tPA ) , and total plasminogen activator inhibitor 1 ( PAI 1 ) concentrations by use of an enzyme linked immunosorbent assay . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We determined whether or not genetic variability in the promoter region of the gene encoding plasminogen activator inhibitor 1 ( PAI 1 ) contributes to individual differences in susceptibility to the development of preeclampsia . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To investigate the association between the plasminogen activator inhibitor 1 ( PAI 1 ) 4G / 5G gene polymorphism and the occurrence of myocardial and cerebrovascular infarctions in individuals from Tianjin , China . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The increased release of plasminogen activator inhibitor 1 ( PAI 1 ) as seen in sepsis decreases fibrinolysis and promotes increased microvascular thrombosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Within 2 weeks , samples were thawed and prepared for the following assays : thrombin antithrombin complexes ( TAT complexes ) , D dimers , plasminogen activator inhibitor type 1 ( PAI 1 ) , and plasminogen and plasmin inhibitor . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : Increased plasminogen activator inhibitor 1 ( PAI 1 ) concentrations after coronary artery bypass grafting ( CABG ) are associated with increased risk of vein graft occlusion . ^^^ METHODS AND RESULTS : We measured the effects of cardiopulmonary bypass ( CPB ) on PAI 1 antigen and tissue type plasminogen activator ( tPA ) antigen and activity in 31 patients taking an ACE inhibitor ( ACEI ) who were randomized to continue ACEI until the morning of surgery ( ACEI group , n=19 ) or to discontinue it 48 hours before surgery ( No ACEI group , n=12 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the last few months , there have been three sets of new , provocative data that might have important implications for the daily prescription of adjuvant chemotherapy ( CT ) in the future . ( 1 ) Urokinase type plasminogen activator ( UPA ) and type 1 plasminogen activator inhibitor ( PAI 1 ) , two molecular markers of invasion already known for their powerful prognostic value in node negative breast cancer , seem to predict for enhanced benefit from adjuvant CT , while the benefit from adjuvant endocrine therapy seems independent of them . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Immunohistochemical and in situ hybridization studies of the expression of the direct activators of MMP 2 , MT 1 MMP and MT 3 MMP , and the indirect activation system tissue plasminogen activator , urokinase ( u PA ) , its receptor ( u PAR ) , and its inhibitor PAI 1 after middle cerebral artery occlusion / reperfusion were undertaken in basal ganglia samples from 26 adolescent male baboons . ^^^ The expressions of all three MMPs , u PA , u PAR , and PA 1 1 , but not tissue plasminogen activator , were increased from 1 hour after middle cerebral artery occlusion in the ischemic core . mRNA transcripts confirmed the increases in latent MMP 2 , u PA , u PAR , and PAI 1 antigen very early after middle cerebral artery occlusion . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue type plasminogen activator ( T PA ) and plasminogen activator inhibitor ( PAI 1 ) in human follicular fluid during gonadotropin induced ovulation ] . ^^^ Concentrations of tissue type plasminogen activator in FF of patients with 5 or more mature oocyte were significantly lower ( 0 . 017 vs 0 . 056 ng / mg ) and levels of PAI 1 higher ( 3 . 49 vs 2 . 9 ng / mg ) in comparison to cases involving < 5 oocytes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Further , plasminogen activator inhibitor 1 ( PAI 1 ) mRNA expression in renal cortex was attenuated after low dose TGF beta antibody treatment compared to control and high dose group ( PAI 1 / glyceraldehyde 3 phosphate dehydrogenase ( GAPDH ) mRNA ratio , NL 0 . 18 + / 0 . 003 ; control 0 . 45 + / 0 . 03 ; high 0 . 40 + / 0 . 04 ; low 0 . 23 + / 0 . 01 ; P < 0 . 05 low vs . control and high ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Several activated coagulation factors have been reported to enhance fibrinolysis by neutralizing plasminogen activator inhibitor type 1 ( PAI 1 ) activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Concentrations of plasminogen activator inhibitor 1 ( PAI 1 ) are elevated beginning at the stage of impaired glucose tolerance and continuing through the development of diabetes mellitus and the metabolic syndrome . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Protease nexin 1 ( PN 1 ) and plasminogen activator inhibitor 1 ( PAI 1 ) are serine protease inhibitors that bind to the extracellular matrix protein vitronectin ( VN ) with high affinity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Several variables of the fibrinolytic system such as plasminogen activator inhibitor 1 ( PAI 1 ) antigen and activity , tissue plasminogen activator ( t PA ) antigen and activity as well as circulating t PA / PAI 1 complexes were determined . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is the main inhibitor of plasminogen activators and plays an important role in many pathophysiological processes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : We studied the activities of tissue plasminogen activator ( tPA ) and plasminogen activator inhibitor 1 ( PAI 1 ) and the levels of tPA antigen ( a marker of endothelial dysfunction ) in 551 subjects with normal glucose tolerance in 1990 in relation to incident diabetes during nine years of follow up . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma levels of the thrombin activation system ( thrombin antithrombin complex [ TAT ] , tissue factor pathway inhibitor [ TFPI ] , and prothrombin fragments 1+2 [ F1+2 ] ) and plasmin activation system ( tissue and urokinase type plasminogen activator [ t PA and u PA ] , plasminogen activator inhibitor 1 [ PAI 1 ] , and D dimer ) were measured with enzyme linked immunosorbent assay kits before angiography . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In addition , steroid therapy causes hypofibrinolytic state by dose dependent increase in plasminogen activator inhibitor 1 ( PAI 1 ) levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The assay was a non competitive sandwich enzyme linked immunosorbent assay ( ELISA ) based on the production of a specific polyclonal antibody against mouse plasminogen activator inhibitor type 1 ( PAI 1 ) used both as a trapping and detecting antibody . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Renal gene expressions of type 1 plasminogen activator inhibitor ( PAI 1 ) , tissue type PA ( tPA ) , and urokinase type PA ( uPA ) were examined by real time PCR . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The aim of the study was to evaluate associations between some fibrinolytic factors : antigens of tissue type plasminogen activator ( t PA ) , plasminogen activator inhibitor ( PAI 1 ) , and thrombin activatable fibrinolysis inhibitor ( TAFI ) , and IMT in a population of renal transplant recipients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In this study , we investigated if elevation of endogenous plasminogen activator inhibitor type 1 ( PAI 1 ) by lipopolysaccharide ( LPS ) can retard thrombolysis in both a rat model of lung vasculature fibrin deposition and a platelet rich thrombus model induced by endothelial injury . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Impaired fibrinolysis due to an increase in type 1 plasminogen activator inhibitor ( PAI 1 ) might mediate this link . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We analyzed the effects of MM LDL on brain capillary endothelial expression of plasminogen activator inhibitor 1 ( PAI 1 ) , tissue type plasminogen activator ( tPA ) , and thrombomodulin ( TM ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Vitronectin ( VN ) and plasminogen activator inhibitor 1 ( PAI 1 ) have important functional interactions : VN stabilises the protease inhibitory activity of PAI 1 and PAI 1 inhibits binding of adhesion receptors to VN . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Although numerous studies have shown elevated plasminogen activator inhibitor 1 ( PAI 1 ) levels in keloid fibroblasts compared with those of normal skin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Rather , HGF appeared to induce fibrinolytic pathways by increasing expression of metalloproteinase 9 ( MMP 9 ) and decreasing levels of plasminogen activator inhibitor 1 ( PAI 1 ) and tissue inhibitor of metalloproteinase 1 ( TIMP 2 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Neointima formation and thrombosis after vascular injury in transgenic mice overexpressing plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^ The controversial role of plasminogen activator inhibitor 1 ( PAI 1 ) in neointima formation and restenosis was studied with the use of a vascular injury model in transgenic mice overexpressing murine PAI 1 ( PAI 1 Tg ) and in wild type ( WT ) controls . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To determine the concentration of selected haemostatic factors ( HFs ) : thrombin antithrombin complexes ( TAT ) , antithrombin ( AT ) , tissue plasminogen activator ( t PA ) , plasminogen activator inhibitor type 1 ( PAI 1 ) and D dimers in carotid bifurcation plaques and to compare plaque composition in different subgroups of patients ( mainly those with symptomatic and asymptomatic carotid stenosis ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fibrinolysis was determined by tissue plasminogen activator ( tPA ) , plasminogen activator inhibitor ( PAI 1 ) and fibrin degradation product ( D dimer ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The antithrombotic mechanism of novel compounds is not relevant to hemostatic systems or functions of platelet aggregation directly , but they can promote endothelial cells to release tissue type plasminogen activator ( t PA ) and inhibit the activity of plasminogen activator inhibitor 1 ( PAI 1 ) . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Adipocyte production of plasminogen activator inhibitor 1 ( PAI 1 ) , an inhibitor of fibrinolysis , and angiotensin 2 secretion are partially corrected by PPARgamma activation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Synthesis and biological evaluation of piperazine based derivatives as inhibitors of plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) plays a critical role in tissue fibrosis by inactivating matrix metalloproteinases , which might effect on the progression of left ventricular dysfunction . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This system comprises of , among others , the urokinase type plasminogen activator ( uPA ) and its main inhibitor ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Increased plasminogen activator inhibitor 1 ( PAI 1 ) has been linked to not only thrombosis and fibrosis but also to obesity and insulin resistance . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Because vascular tissue is a source of the endogenous fibrinolytic markers , and ACE inhibition in vascular tissue favorably influences the fibrinolytic system , the authors hypothesized that a high tissue penetrating ACE inhibitor would provide a more favorable reduction in plasminogen activator inhibitor 1 ( PAI 1 ) and an increase in tissue plasminogen activator ( t PA ) after AMI compared to a low tissue penetrating ACE inhibitor . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The activity of type 1 plasminogen activator inhibitor ( PAI 1 ) in rat plasma or platelet released substances and tissue type plasminogen activator ( tPA ) in rat plasma was assayed by use of a chromogenic substrate . ^^^ PO : persistent occlusion CR : cyclic reflow PP : persistent patency PAI 1 : type 1 plasminogen activator inhibitor tPA : tissue type plasminogen activator PBS : phosphate buffer solution IC ( 50 ) : 50 % of inhibitory concentration PRP : platelet rich plasma ADP : adenosine diphosphate AA : arachidonic acid PAF : platelet activating factor . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : Total cholesterol , HDL cholesterol , triglycerides , plasminogen inhibitor plasminogen type 1 ( PAI 1 ) and fibrinogen were measured , whereas LDL cholesterol was calculated by means of Friedewald ' s formula . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The urokinase plasminogen activator ( uPA ) system consists of the serine protease uPA , its glycolipid anchored receptor , uPAR and its 2 serpin inhibitors , plasminogen activator inhibitor 1 ( PAI 1 ) and plasminogen activator inhibitor 2 ( PAI 2 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Thirty two genes were reduced , among them cystein rich angiogenic protein ( 14 . 9+ / 1 . 3 ) , monocyte chemotactic protein 1 ( 7 . 4+ / 1 . 1 ) and plasminogen activator inhibitor PAI 1 ( 4 . 5+ / 0 . 5 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma concentrations of high sensitivity C reactive protein ( CRP ) , serum amyloid A ( SAA ) , plasminogen activator inhibitor 1 ( PAI 1 ) , creatine kinase ( CK ) , and CK MB were measured at baseline and sequentially for 48 hours . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We measured markers of nutrition [ normalized protein catabolic rate ( nPCR ) , albumin , prealbumin , insulin like growth factor 1 ( IGF 1 ) , transferrin , and cholesterol ] , markers of endothelial damage and function [ tissue type plasminogen activator ( tPA ) , thrombomodulin ( TM ) , von Willebrand factor ( vWF ) , and NO 3 ( representing NO ) ] , markers of a coagulable state [ fibrinogen and plasminogen activator inhibitor 1 ( PAI 1 ) ] , markers of inflammation [ tumor necrosis factor alpha ( TNF alpha ) and C reactive protein ( CRP ) ] , and other endothelial injury factors [ lipoprotein ( a ) [ Lp ( a ) ] and homocysteine ] . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) levels were found to be associated with obesity indicating that adipocytes influence PAI 1 plasma levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To assess the relationship of these AGEs to endothelial function and inflammation , markers of endothelial function von Willebrand factor ( vWf ) , soluble vascular cellular adhesion molecule 1 ( sVCAM 1 ) , soluble E selectin ( sE selectin ) , soluble thrombomodulin ( sTM ) , tissue type specific plasminogen activator ( tPA ) and plasminogen activator inhibitor 1 ( PAI 1 ) , and C reactive protein ( CRP ) , a marker of inflammatory activity , were determined by enzyme linked immunosorbent assays . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is a 43 kDa protein involved in the regulation of fibrinolysis . ^^^ PAI 1 is the principal inhibitor of tissue type plasminogen activator ( t PA ) , trapping the proteinase as an acyl enzyme covalent complex ( approximately 105 kDa ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We investigated the relationship between weekly alcohol intake and interleukin 6 ( IL 6 ) , C reactive protein ( CRP ) , tumor necrosis factor alpha ( TNF alpha ) , and plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Statins decreased plasma concentrations of troponine T , high sensitive C reactive protein ( hsCRP ) , plasminogen activator inhibitor 1 ( PAI 1 ) and tumor necrosis factor alpha ( TNFalpha ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHOD : We studied urokinase ( uPA ) , tissue type plasminogen activator ( tPA ) , urokinase receptor ( uPAR ) and plasminogen activator inhibitor 1 ( PAI 1 ) expression by in situ hybridization and by immunohistochemistry in 14 NF 2 and 15 sporadic patients with 34 schwannomas . uPAR and vitronectin immunohistochemistry were also studied . ^^^ CONCLUSIONS : Schwann cells of tumour cell origin , both in sporadic and NF 2 schwannomas , expressed elevated levels of plasminogen activators and PAI 1 compared to normal suralic nerve Schwann cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Prior work , using a mixed species co culture system , has shown astrocyte regulation of brain capillary endothelial expression of key hemostasis factors tissue plasminogen activator ( tPA ) and its inhibitor , plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
INTRODUCTION : Cardiopulmonary bypass ( CPB ) is associated with elevated tissue plasminogen activator ( t PA ) levels during CPB and increased plasminogen activator inhibitor 1 ( PAI 1 ) levels post operatively . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The most investigated novel risk factors of atherosclerosis are : fibrinogen ( Fb ) , homocysteine ( Hcy ) , lipoprotein ( a ) ( Lp ( a ) ) , plasminogen activator inhibitor ( PAI 1 ) , markers of inflammation and infectious factors . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Vascular endothelial growth factor ( VEGF ) and such plasminogen activation system components as uPA , PAI 1 and tPA were determined by enzyme immunoassay methods in endometrial tumors from 121 patients and 18 samples of endometrial hyperplasia of varying degree . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
EXPERIMENTAL DESIGN : In a case control study , we studied polymorphisms of the genes coding for factor 2 ( G20210A ) , factor 5 ( G1691A ) , methylenetetrahydrofolate reductase ( C677T ) , tissue type plasminogen activator ( tPA ; insertion / deletion ) , plasminogen activator inhibitor 1 ( PAI 1 ; 4G / 5G ) , and vascular endothelial growth factor ( VEGF ; C936T ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
PURPOSE AND EXPERIMENTAL DESIGN : To test whether plasminogen activator inhibitor 1 ( PAI 1 ) can serve as a candidate marker for the malignancy of esophageal squamous cell carcinoma ( SCC ) , we performed a quantitative reverse transcription PCR for PAI 1 gene and evaluated the possible relationship between PAI 1 gene expression levels and clinicopathological findings in esophageal SCC . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Previous studies have shown that plasminogen activator inhibitor 1 ( PAI 1 ) can be upregulated by hypoxia and may contribute to keloid pathogenesis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVES : To measure the plasma levels of urokinase plasminogen activator ( uPA ) , urokinase plasminogen activator receptor ( uPAR ) and plasminogen activator inhibitor 1 ( PAI 1 ) , and study the relationship between the plasma levels of uPA , PAI 1 and the serum albumin ( Alb ) , collagen type 4 ( CIV ) , the serum hyaluronic acid ( HA ) , prothrombin time ( PT ) and prothrombin activity ( PTA ) in patients with different stages of liver cirrhosis following chronic hepatitis B . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The level of plasminogen activator inhibitor 1 ( PAI 1 ) in tumor tissue has been shown to be an independent negative prognostic factor in different cancers . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have previously demonstrated elevated levels of the fibrinolytic factors urokinase plasminogen activator ( uPA ) and plasminogen activator inhibitor ( PAI 1 ) in endometriotic tissue and endometrium from women with endometriosis . ^^^ The aim of the present study was to localize the uPA , PAI 1 and urokinase plasminogen activator receptor ( uPAR ) mRNA in endometriotic tissue and in endometrium both from women with and without endometriosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In addition , soluble intercellular adhesion molecule 1 , vascular cell adhesion molecule 1 , E selectin , leptin , high sensitivity C reactive protein , plasminogen activating factor 1 ( PAI 1 ) , and tissue plasminogen activator were measured . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Components of the plasmin system including tissue plasminogen activator ( t PA ) , urokinase plasminogen activator ( u PA ) , and plasminogen activator inhibitors PAI 1 and PAI 2 are synthesised by airway cells , and inflammatory mediators affect their expression . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Lipoproteins , plasminogen activator inhibitor type 1 ( PAI 1 ) , fibrinogen , and C reactive protein ( CRP ) were measured in fasting plasma samples . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Individuals with greater Plasminogen Activator Inhibitor 1 ( PAI 1 ) level are believed to be more susceptible to cardiovascular disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND AND OBJECTIVE : The 4G / 5G plasminogen activator inhibitor 1 ( PAI 1 ) promoter polymorphism has been associated with basal PAI 1 levels , with ischemic heart disease , and with adverse prognosis in critically ill patients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We previously reported KLF5 / BTEB2 , a Krppel like zinc finger type transcription factor , to activate various gene promoters that are activated in phenotypically modulated smooth muscle cells , such as a nonmuscle type myosin heavy chain gene SMemb , plasminogen activator inhibitor 1 ( PAI 1 ) , iNOS , PDGF A , Egr 1 and VEGF receptors at least in vitro . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The BBB endothelium also expresses tissue plasminogen activator ( tPA ) , a key protein in fibrinolysis , and its rapid inhibitor , plasminogen activator inhibitor ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To evaluate the effect of repeated thoracenteses on the fluid characteristics and the levels of various cytokines , including tumor necrosis factor ( TNF ) alpha , interleukin ( IL ) 1beta , IL 5 , IL 6 , and IL 8 , and of plasminogen activator inhibitor type 1 ( PAI 1 ) and tissue type plasminogen activator in malignant pleural effusion and its clinical significance . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To clarify the role of proteins involved in the regulation of fibrinolysis during corneal angiogenesis , we have studied corneal vessel formation in mice deficient for urokinase type plasminogen activator ( uPA ) , tissue type plasminogen activator ( tPA ) , plasminogen , plasminogen activator inhibitor 1 ( PAI 1 ) and thrombin activatable fibrinolysis inhibitor ( TAFI ) . ^^^ Our results corroborate earlier findings that angiogenesis in the mouse cornea is dependent on PAI 1 and plasminogen . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In this study of nasal mucosa , we investigated the presence of mRNA of tissue type plasminogen activator ( t PA ) , urokinase type plasminogen activator ( u PA ) , plasminogen activator inhibitor 1 ( PAI 1 ) , and plasminogen activator inhibitor 2 ( PAI 2 ) using reverse transcription polymerase chain reaction ( RT PCR ) and in situ hybridization , and compared these results with their localization in immunostained tissues . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Smad proteins transduce the TGF beta mediated signal , and Smad binding CAGA sequences are present in the plasminogen activator inhibitor 1 ( PAI 1 ) promoter . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
However , there was no significant difference of plasminogen activator inhibitor 1 ( PAI 1 ) , pro uPA , and tissue type plasminogen activator ( tPA ) concentrations in the medium between dDAVP treatment and control . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Prompted by the conspicuous absence of studies examining the role of the ME in breast cancer progression , we studied the expression of the urokinase plasminogen activator receptor ( uPAR ) and plasminogen activator inhibitor type 1 ( PAI 1 ) in MEs of 60 DCIS samples . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Differential localization and expression of urokinase plasminogen activator ( uPA ) , its receptor ( uPAR ) , and its inhibitor ( PAI 1 ) mRNA and protein in endometrial tissue during the menstrual cycle . ^^^ Cyclic variation and distribution of uPA , uPAR and plasminogen activator inhibitor 1 ( PAI 1 ) mRNA were examined by in situ hybridization , real time PCR and northern blot in normal endometrium . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The purpose of this study was to test the effects of oral fat challenge , composing 30 % calories of a meal , on blood glucose , insulin , lipid , leptin , plasminogen activator inhibitor 1 ( PAI 1 ) and tumor necrosis factor alpha ( TNF alpha ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : Paradoxically , fibrinolytic agents may systemically activate platelets , which in turn secrete plasminogen activator inhibitor ( PAI 1 ) , an antagonist of the fibrinolytic process in proportion to total body platelet mass . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Treatment with these agents has a range of anti atherogenic effects , including reduced levels of CRP , plasminogen activator inhibitor 1 ( PAI 1 ) , TNF alpha and reactive oxygen species . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The plasminogen activation system includes the urokinase type plasminogen activator ( uPA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) , among other molecules . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The secretion rate of leptin decreased by approximately 40 % , as did that of tumor necrosis factor alpha ( TNF alpha ) , and interleukin ( IL ) 6 and 8 decreased by 25 30 % , whereas the secretion of plasminogen activator inhibitor 1 ( PAI 1 ) and adiponectin did not show any changes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We measured 1 ) proinflammatory cytokines ( tumor necrosis factor alpha , interleukin [ IL ] 6 , IL 1 beta , and IL 8 ) , 2 ) markers of cardiovascular risk ( C reactive protein [ CRP ] , homocysteine , and plasminogen activator inhibitor 1 [ PAI 1 ] ) , 3 ) products of reactive oxygen species ( ROS ; thiobarbituric acid [ TBA ] reacting material , and dichlorofluorescein [ DCF ] ) , and 4 ) cortisol , growth hormone ( GH ) , and free fatty acids ( FFAs ) on admission ( before insulin therapy ) and after insulin therapy and resolution of hyperglycemia and / or ketoacidosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : Serial bronchoalveolar lavage fluid ( BALF ) samples were assayed for prothrombin activation fragment ( F1+2 ) , thrombin antithrombin ( TAT ) complex , fibrinolytic activity , urokinase type plasminogen activator ( u PA ) , and plasminogen activator inhibitor type 1 ( PAI 1 ) on days 1 , 4 , and 7 after VAP onset . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
However , enzyme linked immunosorbent assays ( ELISA ) of uPA antigen , and the activities of tissue plasminogen activator ( tPA ) and plasminogen activator inhibitor 1 ( PAI 1 ) were not statistically different from those in control experiments . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) , is a serpin whose major function is to negate plasminogen activation and impair fibrinolysis . ^^^ Differences between results depend on the types and the lengths of the models and underline the fact that besides its role in regulating fibrinolysis , PAI 1 plays a role in several cellular processes independent of plasminogen activation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) may contribute to renal fibrosis because of its involvement in matrix ( ECM ) accumulation through inhibition of plasmin dependent ECM degradation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
LRP protein was reduced and extracellular accumulation of urokinase type plasminogen activator ( uPA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) proteins were greater in uPAR / cultures . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Host derived plasminogen activator inhibitor 1 ( PAI 1 ) concentration is critical for in vivo tumoral angiogenesis and growth . ^^^ Plasminogen activator inhibitor type 1 ( PAI 1 ) plays a key role in tumor progression and is believed to control proteolytic activity and cell migration during angiogenesis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To investigate the molecular mechanisms involved in the estrogen dependent control of plasminogen activator inhibitor 1 ( PAI 1 ) gene expression in vascular cells , we compared the transactivation properties of estrogen receptors ( ERalpha and ERbeta ) in regulating the activity of a human PAI 1 promoter reporter construct in transfected bovine aortic endothelial cells ( BAECs ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : Plasminogen activator inhibitor type 1 ( PAI 1 ) plays a central role in fibrolysis and has recently been hypothesized to influence components of the insulin resistance syndrome . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma levels of fibrinopeptide A ( FPA ) , fibrin d dimer , thrombin antithrombin ( TAT ) complex , prothrombin fragment 1 . 2 ( F1 . 2 ) , urokinase type plasminogen activator ( uPA ) , tissue type plasminogen activator ( t PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) were measured before and after therapy , as was the cellular expression of the genes for tissue factor ( TF ) and interleukin 1 beta ( IL 1 beta ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is the major physiological inhibitor of both tissue type plasminogen activator ( tPA ) and urokinase type plasminogen activator ( uPA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Diabetes is associated with an excess risk of cardiac events , and the risk for infarction is partly determined by plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The plasminogen system participates in this process with the balance between urokinase type plasminogen activator ( uPA ) and plasminogen activator inhibitor 1 ( PAI 1 ) being a critical determinant of the extent of collagen accumulation that follows lung injury . ^^^ Because the plasminogen system is known to influence the rate of migration of epithelial cells , including keratinocytes and bronchial epithelial cells , we hypothesized that the balance of uPA and PAI 1 would affect the efficiency of alveolar epithelial cell ( AEC ) wound repair . ^^^ The significant effect of uPA and PAI 1 on epithelial repair suggests a mechanism by which the plasminogen system may modulate pulmonary fibrosis . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The aim of this study was to analyze the distribution of plasminogen activator inhibitor 1 ( PAI 1 ) promoter 4G / 5G polymorphism in healthy Chinese and compare the transcription activity of the two PAI 1 promoters using luciferase reporter vector pGL ( 3 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
High plasminogen activator inhibitor 1 ( PAI 1 ) levels are potential risk factors for cardiovascular disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
As another potentially atherogenic factor , impaired fibrinolytic activity due to increased plasminogen activator inhibitor 1 ( PAI 1 ) concentrations has been shown . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Previous studies have suggested that plasminogen activator inhibitor 1 ( PAI 1 ) released from platelets convey resistance of platelet rich blood clots to thrombolysis . ^^^ The activity of the newly formed PAI 1 was investigated by incubating platelets in the presence of tissue type plasminogen activator ( tPA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The increasing number of products secreted by adipocytes also includes leptin , estrogen , angiotensinogen , plasminogen activator inhibitor 1 ( PAI 1 ) , tissue factor and transforming growth factor beta ( TGF beta ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
It modifies some important hemostasis components in blood : ( 1 ) DeltaO ( 2 ) ( * ) inactivates the factors 1 ( fibrinogen ) , 5 , 8 , vWF , 10 , plasminogen activator inhibitor 1 ( PAI 1 ) , and alpha 2 antiplasmin . ( 1 ) DeltaO ( 2 ) ( * ) oxidation of plasminogen and fibrin facilitates their specific cleavage by plasminogen activators and plasmin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the study reported here we examined the expression of plasminogen activator inhibitor 1 ( PAI 1 ) , urokinase type plasminogen activator ( uPA ) , and uPA receptor ( uPAR ) , as well as the relevance of such expression to the production of type 4 collagen , a major component of extracellular matrix , in the renal tissue of rats with streptozotocin induced diabetes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is up regulated strongly in various cancer tissues , including colon cancer tissue . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Supernatant prostaglandin E 2 and mRNA expressions of COX 2 , vascular endothelial growth factor ( VEGF ) , urokinase type plasminogen activator ( u PA ) , u PA receptor , plasminogen activator inhibitor type 1 ( PAI 1 ) , and PAI 2 were measured . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Polymorphisms in the thrombophilia genes [ plasminogen activator inhibitor type 1 [ PAI 1 675 ( 4G / 5G ) ] , thrombin activatable fibrinolysis inhibitor ( TAFI 438G / A and 1040C / T ) , methylenetetrahydrofolate reductase ( MTHFR 677C / T ) , factor 5 ( FV Leiden R / Q506 ) , prothrombin ( FII 20210G / A ) and factor XIIIA ( FXIIIA V / L34 ) ] were determined in 157 women with preeclampsia and 157 women with uncomplicated pregnancy . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Both glimepiride and metformin lowered plasminogen activator inhibitor Type 1 ( PAI 1 ) at 12 months and significantly improved levels of glycosylated haemoglobin , fasting plasma glucose and post prandial plasma glucose after 6 and 12 months . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Latency and substrate binding globally reduce solvent accessibility of plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^ Plasminogen activator inhibitor type 1 ( PAI 1 ) plays key regulatory roles in fibrinolysis , cell migration , and tissue remodeling . ^^^ A regulatory protein without known catalytic activity , PAI 1 modulates plasminogen activators through protein protein interactions . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In this murine model of CsA nephropathy under ACE blockade , plasminogen activator inhibitor 1 ( PAI 1 ) expression was decreased in tubular epithelial cells , possibly leading to conversion of plasminogen to plasmin by plasminogen activator and subsequent activation of matrix metalloproteinases . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The aim of this study was to evaluate the expression of urokinase plasminogen activator ( uPA ) , its receptor ( uPAR ) and the plasminogen activator inhibitor type 1 ( PAI 1 ) in human aorta , and to balance them with the stage of atherosclerotic lesion . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Quantitative gene expression analysis ( real time RT PCR ) was performed for tissue factor ( TF ) , TF pathway inhibitor ( TFPI ) , tissue type plasminogen activator ( t PA ) , urokinase type PA ( u PA ) , PA inhibitor 1 ( PAI 1 ) , and PAI 2 in peripheral white blood cells ( PBC ) as well as in alveolar macrophages ( AM ) , type 2 pneumocytes ( ATII ) , endothelial cells ( EC ) and smooth muscle cells ( SMC ) , all obtained by laser microdissection . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasmin hyperactivity due to decreased plasminogen activator inhibitor 1 ( PAI 1 ) may cause MMP over activity and coronary aneurysms . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : In a prospective , longitudinal , case control study , we studied plasma plasminogen activator inhibitor type 1 ( PAI 1 ) activity , tissue type plasminogen activator antigen ( t PA : Ag ) , d dimer , prothrombin fragment 1+2 ( F 1+2 ) , and thrombin antithrombin 3 complex ( TAT ) levels in 55 consecutive patients on admission , 1 week , 1 month , and 3 months after an ischemic stroke . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Prothrombin fragment 1 + 2 , fibrinogen , factor 8 , antithrombin , tissue plasminogen activator antigen ( tPA ) , plasminogen activator inhibitor 1 ( PAI 1 ) , PAI 1 / tPA , and C reactive protein were significantly ( P < 0 . 05 ) higher in the hyper than in the hypothyroid state , whereas protein C and plasmin antiplasmin complexes were significantly lower during the hyperthyroid period . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is the most important endogenous inhibitor of tissue plasminogen activator and uro plasminogen activator , and is a main determinant of fibrinolytic activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Haemostatic management of intraoral bleeding was investigated in patients with congenital alpha 2 plasmin inhibitor ( alpha 2 PI ) deficiency or congenital plasminogen activator inhibitor 1 ( PAI 1 ) deficiency . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
PAI 1 , the physiological inhibitor of tissue type and urokinase type plasminogen activator , is a unique member of the serpins as it exists in three distinct conformations : an active inhibitory conformation , a non inhibitory substrate conformation , and a non reactive latent conformation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is a key factor behind fibrinolytic activity , and its gene expression is controlled under the circadian clock gene in the mouse heart and liver . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
ROK also controls plasminogen activator inhibitor 1 ( PAI 1 ) which promotes vascular fibrosis contributing to atherogenesis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : The aim of this study was to evaluate the effect of the amlodipine atorvastatin combination on plasma tissue plasminogen activator ( t PA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) activity in hypercholesterolemic , hypertensive patients with insulin resistance . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The plasma levels of plasminogen activator inhibitor 1 ( PAI 1 ) antigen , tissue plasminogen activator inhibitor ( tPA ) antigen , thrombomodulin ( TM ) , tissue factor pathway inhibitor ( TFPI ) antigen , and fibrinogen were determined before and after 6 months of therapy . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
HIV infected subjects who have lipodystrophy and insulin resistance on prolonged antiretroviral therapy have elevated levels of tissue plasminogen activator ( tPA ) and plasminogen activator inhibitor 1 ( PAI 1 ) antigens , markers of impaired thrombolysis that are associated with hyperinsulinemia and increased cardiovascular risk . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
While microarray analyses identified a number of involved genes , plasminogen activator inhibitor type 1 ( PAI 1 ) is among the subset most highly responsive to TGF beta 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The net balance between urokinase type plasminogen activator ( uPA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) has been implicated in tumor cell invasion and metastasis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Because absence of urokinase plasminogen activator ( uPA ) prevents development of cardiac fibrosis after experimental myocardial infarction in mice , we hypothesized that elevated activity of uPA or deficiency of the uPA inhibitor plasminogen activator inhibitor 1 ( PAI 1 ) might cause cardiac fibrosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fibrinolysis is controlled by plasminogen activators inhibitor ( PAI 1 ) , alpha 2 antiplasmin and alpha 2 macroglobulin , and thrombin activatable fibrinolysis inhibitor ( TAFI ) . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is an important component of the plasminogen / plasmin system as it is the main inhibitor of tissue type and urokinase type plasminogen activator . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We measured the plasma levels of free form tissue factor pathway inhibitor ( free TFPI ) , plasminogen activator inhibitor 1 ( PAI 1 ) , and von Willebrand factor ( vWF ) in 522 adults without cardiovascular disease enrolled in the Suita Study . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Modified lipoproteins have been suggested to modulate endothelial expression of plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Changes in expression of components of this system , including plasminogen activator inhibitor 1 ( PAI 1 ) , have been associated with poor prognosis in a variety of solid tumors . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tumor levels of BCAR 1 were correlated with relapse free survival ( RFS ) and overall survival ( OS ) and compared with collected data on urokinase type plasminogen activator ( uPA ) and plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Such IGF independent effects involve potential interactions with components of the extracellular matrix involved in tissue remodelling including plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Diurnal changes of fibrinolysis such as lower activity of tissue plasminogen activator and higher activity of plasminogen activator inhibitor 1 ( PAI 1 ) in the morning has been demonstrated previously and correspond with the manifestation of ACS . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In week 20 , the following parameters were determined : blood lymphocyte number , kidney function , both glomerular and tubulointerstitial histologic matrix accumulation , protein expression of transforming growth factor beta 1 ( TGF beta 1 ) , fibronectin , and plasminogen activator inhibitor 1 ( PAI 1 ) as well as infiltration with macrophages and lymphocytes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Among the 3 groups of rats , we compared renal fibrosis and renal hypertrophy , using picro sirius red staining and immunohistochemistry of ED 1 macrophage marker , plasminogen activator inhibitor 1 ( PAI 1 ) , and transforming growth factor ( TGF ) beta 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Bleeding time , platelet count , prothrombin time , activated partial thromboplastin time , tissue plasminogen activator ( tPA ) , plasminogen activator inhibitor ( PAI 1 ) , euglobulin clot lysis time , protein C , protein S , fibrinogen , D dimer , factor 5 , 7 , 8 , 9 , 10 and von Willebrand factor ( VWF ) values were studied at the beginning , at 2 and 4 h of dialysis with and without administration of DDAVP at a dose level of 2 microg / kg intranasally . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
There are also traces of fibrinogen , plasminogen , plasminogen activator inhibitor 1 ( PAI 1 ) , factor 8 coagulant activity ( 8 : c ) and fibrin monomers . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : Tissue factor ( TF ) and plasminogen activator inhibitor 1 ( PAI 1 ) activity and / or expression are upregulated in obesity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Among biochemical investigations , an increase in the plasminogen activator inhibitor type 1 ( PAI 1 ) levels associated with mild hyperhomocysteinemia was present . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fibrinolysis was quantified by measurement of the activity levels of tissue plasminogen activator ( tPA , the activator of fibrinolysis ) and its inhibitor plasminogen activator inhibitor 1 ( PAI 1 ) , using an amidolytic method . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Other novel HCV IRES binding proteins included UNR ( upstream of N ras ) , UNR interacting protein , and the RNA binding proteins PAI 1 ( plasminogen activator inhibitor 1 ) mRNA binding protein and Ewing sarcoma breakpoint 1 region protein EWS . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Levels of fibrinogen , of the antifibrinolytic enzyme type 1 plasminogen activator inhibitor ( PAI 1 ) , and of the hypercoagulability marker fibrin D dimer were measured in plasma . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : The plasminogen activator inhibitor 1 ( PAI 1 ) 4G / 4G genotype influences the development of diabetic nephropathy and lupus nephritis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Angiotensin 2 stimulates the expression of tissue factor ( TF ) and plasminogen activator inhibitor type 1 ( PAI 1 ) , and AT 1 receptor blockade ( ARB ) reduces PAI 1 and TF activities in experimental studies . ^^^ We investigated the effects of ARBs on TF activity , tissue plasminogen activator ( tPA ) , PAI 1 antigen levels , plasma renin activity ( PRA ) and aldosterone levels in hypertensive patients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
All patients underwent a screening prothrombin time , activated partial thromboplastin time , fibrinogen ( Fg ) , coagulation factors of the intrinsic and extrinsic pathways , antithrombin 3 ( AT 3 ) , protein C ( PC ) , protein S ( PS ) , resistance to activated protein C , prothrombin activation fragment 1+2 ( F1+2 ) , plasminogen , tissue type plasminogen activator ( t PA ) , plasminogen tissue activator inhibitor type 1 ( PAI 1 ) , anticardiolipin antibodies type M and G ( ACA IgM and ACA IgG ) , lupus anticoagulant antibodies , and antiprothrombin antibodies type M and G ( aPT IgM and aPT IgG ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fibrinolytic activity in the acute stroke was examined by monitoring the level of plasminogen activator inhibitor 1 ( PAI 1 ) , as one of the indicators of fibrinolytic activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Non muscle alpha actinin 4 interacts with plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Production of plasminogen activator inhibitor 1 ( PAI 1 ) , which is under the specific control of TGF beta , was strongly enhanced ( 3 . 5 fold ) by TGF beta treatment . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : AA Na 40 microg / ml , with or without 10 % S YRS , was co cultured with hRIFs , then the hRIFs mRNA of transforming growth factor beta 1 ( TGF beta 1 ) , connective tissue growth factor ( CTGF ) , plasminogen activator inhibitor 1 ( PAI 1 ) , tissue inhibitor of metalloproteinase 1 ( TIMP 1 ) and type 1 collagen ( Col 1 ) in the cultured cells were detected by RT PCR , and their protein expression monitored with ELISA and Western blot respectively . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Glomerular mRNA and production of fibronectin , plasminogen activator inhibitor 1 ( PAI 1 ) , TGF beta 1 , and p Smad 2 protein were also reduced . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The 24 cases differed from 93 normal white female controls for the factor 5 Leiden mutation , 17 % vs . 2 % , Fisher ' s p [ p ( f ) ] = . 016 , and for the 4G4G mutation of the plasminogen activator inhibitor 1 ( PAI 1 ) gene ( 46 % vs . 24 % , Chi square 4 . 63 , p = . 031 ) . ^^^ The patients also differed from 44 normal white female controls for high levels ( > 21 . 1 U / mL ) of the PAI 1 gene product , plasminogen activator inhibitor activity ( PAI Fx ) ( 33 % vs . 8 % , p ( f ) = . 018 ) , and for high factor 8 ( > 150 % ) ( 22 % vs . 0 % , p ( f ) = . 037 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the present study , we tried to elucidate the mechanism by which bik also inhibits plasminogen activator inhibitor type 1 ( PAI 1 ) and collagen synthesis using human ovarian cancer cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Levels of antithrombin 3 , fibrinogen and plasminogen activator inhibitor 1 ( PAI 1 ) increased , whereas a reduction was observed in proteins C and S and in prothrombin time ( PT ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Semi quantitative analysis was used to observe stained intensity and area of tissue type plasminogen activator , urokinas type plasminogen activator / plasminogen activator inhibitor ( tPA , uPA / PAI 1 ) in remnant renal tissue . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Therefore , in human umbilical vein endothelial cells ( HUVECs ) , the potential effect of IGFs on the synthesis of plasminogen activators ( PAs ) , PA inibitor 1 ( PAI 1 ) , and vasodilator and vasoconstrictor prostaglandins ( PGs ) was investigated . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activation is believed to be critical to the progression of oral squamous cell carcinoma by facilitating matrix degradation during invasion and metastasis , and high levels of urokinase plasminogen activator ( uPA ) and plasminogen activator ( PA ) inhibitor 1 ( PAI 1 ) in tumors predict poor disease outcome . ^^^ Laser capture microdissection ( LCM ) was combined with plasminogen casein zymography to analyze uPA , tissue PA ( tPA ) , uPA PAI 1 complexes , and tPA PAI 1 complexes in 11 tumors and adjacent non malignant epithelium from squamous cell carcinomas of the tongue , floor of mouth , larynx , and vocal cord . uPA was detectable in all tumor samples analyzed , uPA PAI 1 complexes in three samples , and tPA in nine . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
RESULTS : Pretreatment plasminogen activator inhibitor 1 ( PAI 1 ) levels correlated negatively to SHBG and antithrombin 3 ( AT 3 ) negatively to total and free cortisol . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Therefore , the time point at which blood samples are collected postexercise could affect reported tissue plasminogen activator ( t PA ) and / or plasminogen activator inhibitor 1 ( PAI 1 ) levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have studied the expression of urokinase type plasminogen activator ( uPA ) mRNA , uPA receptor ( uPAR ) mRNA and immunoreactivity , and type 1 plasminogen activator inhibitor ( PAI 1 ) mRNA and immunoreactivity in 16 prostate adenocarcinomas and 9 benign prostate hyperplasias . uPA mRNA and uPAR mRNA expression were found in 9 and 8 of the adenocarcinomas , respectively , and in 7 and 6 of the benign hyperplasias , respectively . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The serpin plasminogen activator inhibitor 1 ( PAI 1 ) is a potential therapeutic target in cardiovascular and cancerous diseases . ^^^ A PAI 1 variant ( N ( ( 2 ( iodoacetoxy ) ethyl ) N methyl ) amino 7 nitrobenz 2 oxa 3 diazole ( NBD ) P 9 PAI 1 ) with a fluorescent tag at the reactive center loop ( RCL ) was used to study the effects of vitronectin and monoclonal antibodies ( mAbs ) directed against alpha helix F ( Mab 2 and MA 55F4C12 ) on the reactions of PAI 1 with tissue type and urokinase type plasminogen activators . ^^^ Binding of vitronectin to NBD P 9 PAI 1 does not affect SI but results in a 2 . 0 6 . 5 fold decrease in the limiting rate constant ( klim ) of RCL insertion for urokinase type plasminogen activator at pH 6 . 2 8 . 0 and for tissue type plasminogen activator at pH 6 . 2 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The purpose of the study was to evaluate the plasminogen activator inhibitor 1 ( PAI 1 ) levels and PAI 1 activity in young and lean women with PCOS and to compare with controls matched for age and weight . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fibrinogen , thrombocytes , factor 7 , factor 8 , von Willebrand factor ( vWF ) , thrombomodulin ( TM ) , plasminogen activator inhibitor type 1 ( PAI 1 ) , tissue plasminogen activator ( t PA ) and other haemostatic factors , were described as more or less helpful in estimation of risk of occurrence of coronary artery disease and its cardiovascular complications . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fibrinogen , thrombocytes , factor 8 , von Willebrand factor ( vWF ) , thrombomodulin ( TM ) , plasminogen activator inhibitor type 1 ( PAI 1 ) , tissue plasminogen activator ( t PA ) and other haemostatic factors , play more or less essential role in unstable angina pectoris . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Samples were analyzed for the following : factor 5 Leiden ( FVL ) , prothrombin 20210A ( P20210A ) , methylenetetrahydrofolate reductase C 677 T ( MTHFR ) , Factor 8 ( FVIII ) , Protein C ( PC ) , Lipoprotein ( a ) ( Lp ( a ) ) and plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
AT 1 AA also signal via the calcineurin nuclear factor of activated T cells and contribute to plasminogen activator inhibitor 1 ( PAI 1 ) production and decreased trophoblast invasion . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In contrast , C reactive protein ( C RP ) concentrations decreased slightly by 0 . 7 % and 6 . 6 % ( P = 0 . 046 ) , and those of plasminogen activator inhibitor 1 ( PAI 1 ) antigen by , respectively , 26 % and 53 % ( P < 0 . 001 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Nilvadipine also reduced the expression of fibrinogen and plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The plasminogen activation system was also altered in tumors with a decrease of urokinase type plasminogen activator ( u PA ) and tissue type plasminogen activator ( t PA ) and a strong increase of plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Because GnRH and TGF beta receptor signaling is in part mediated through the MAPK pathway , we determined whether the contribution of MAPK / ERK and transcriptional activation of c fos and c jun , result in differential regulation of type 1 collagen , fibronectin , and plasminogen activator inhibitor 1 ( PAI 1 ) gene expression , whose products are known to influence extracellular matrix turnover , which is critical in leiomyoma growth and GnRHa induced regression . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The deficit of plasminogen activators and the growth of the synthesis of fibrinolysis inhibitors also keep the stage of hypercoagulability , underlined by the growth of plasmatic concentration of the fibrinogen , especially PAI 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The importance of obtaining insight in the structure / function relationship in the serpin plasminogen activator inhibitor type 1 can be understood from the major role PAI 1 plays in different ( patho ) physiological processes , mainly because of its involvement in the plasminogen / plasmin system . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) and tissue factor ( TF ) were highly expressed in lungs after LPS injection . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fasting serum lipids , homocysteine , total and free tissue factor pathway inhibitor ( TFPI ) , plasminogen activator inhibitor ( PAI 1 ) and tissue plasminogen activator ( t PA ) antigen and activity , C reactive protein ( CRP ) , interleukin 6 ( IL 6 ) and tumor necrosis factor alpha ( TNF alpha ) were measured . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor type 1 ( PAI 1 ) is considered one of the key regulators of tumor invasion , metastasis , as well as cancer related angiogenesis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The aim was to investigate if the local availability of active tPA on the organ level depends on the local release rate of tPA or the arterial input of tPA and plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) levels were found to be associated with obesity , indicating that adipocytes might influence PAI 1 plasma levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The main components in plasminogen activation include plasminogen , tissue plasminogen activator ( tPA ) , urokinase plasminogen activator ( uPA ) , urokinase plasminogen activator receptor ( uPAR ) , and plasminogen activator inhibitors 1 and 2 ( PAI 1 , PAI 2 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Moreover , ARA 55 also inhibits the induction of Smad binding element 4 luciferase and 3TP luciferase ( a plasminogen activator inhibitor 1 ( PAI 1 ) promoter construct ) reporters by constitutively active ( CA ) Smad 3 in these cell lines . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The expression of nerve growth factor ( NGF ) and plasminogen activator inhibitor 1 ( PAI 1 ) fell after differentiation , whereas that of TNF alpha and IL 6 changed little . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is the primary physiological inhibitor of plasminogen activation in vivo , and thus it is one of the main regulators of the fibrinolytic system . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) plays an important role in the pathogenesis of obesity driven type 2 diabetes mellitus and associated cardiovascular complications . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor type 1 ( PAI 1 ) is an independent cardiovascular risk factor and increases in patients with Type 2 diabetes mellitus . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) belongs to the serine protease inhibitor ( serpin ) protein family , which has a common tertiary structure consisting of three beta sheets and several alpha helices . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor ( PAI 1 ) , tissue plasminogen activator , von Willebrand factor , fibrinogen , and fibrin D dimer predict risk of coronary heart disease . ^^^ Twenty premenopausal women , mean age 34 + / 7 yr , underwent testing over a cycle to measure endogenous hormones and hemostatic factors : estradiol and progesterone , FSH , LH ; PAI 1 , tissue plasminogen activator , von Willebrand factor , fibrin D dimer , and fibrinogen as well as lipids : total cholesterol , high density lipoprotein cholesterol , low density lipoprotein cholesterol , and triglycerides . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A repeated measures analysis of variance ( ANOVA ) with a between subjects factor revealed significant differences in post transplant levels of antithrombin 3 , tissue plasminogen activator ( tPA ) , plasminogen activator inhibitor 1 ( PAI 1 ) , and D dimer according to the occurrence of VOD . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We quantified fibronectin ( FN ) and plasminogen activator inhibitor 1 ( PAI 1 ) expression as indicators of increased ECM protein synthesis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Moreover , the effects of these compounds were also evaluated under the condition of plasminogen activator inhibitor 1 ( PAI 1 ) deficiency . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma was collected for ELISA analysis . mRNA for MMP 9 as well as plasminogen activator inhibitor 1 ( PAI 1 ) was increased in unstable plaques , while tissue type plasminogen activator ( tPA ) expression was similar in stable and unstable plaques . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Combined determination of urokinase type plasminogen activator ( uPA ) and its inhibitor , activator inhibitor type 1 ( PAI 1 ) , supports risk adapted individualized therapy concepts , particularly in node negative breast cancer . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We measured fibrinogen , D dimer , antithrombin 3 ( ATIII ) , plasminogen activator inhibitor 1 ( PAI 1 ) , tissue plasminogen activator ( tPA ) activity , and factor 7 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This study aimed to evaluate plasminogen activator inhibitor 1 ( PAI 1 ) activity in PCOS . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
RESULTS : Baseline factor 7 tissue factor complex ( VIIa rTF ) , fibrinogen and plasminogen activator inhibitor 1 ( PAI 1 ) levels decreased significantly ( P < 0 . 01 ) after therapy . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Furthermore , we demonstrate that TGF beta 1 induction of the plasminogen activator inhibitor 1 ( PAI 1 ) gene , which is known to be dependent on Smad but not on SRF , is inhibited by PP 1 and apocynin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fibrinolytic variables tissue plasminogen activator ( tPA ) , plasminogen activator inhibitor 1 ( PAI 1 ) activity , and antigen and prothrombin fragment 1 + 2 , a molecular marker of in vivo thrombin generation , were measured before and after maximal exercise . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To investigate the effects of short term atorvastatin treatment on forearm vasodilatory response to reactive hyperaemia ( RH % ) and on components of the thrombosis fibrinolysis system ( antithrombin 3 , proteins and S , factors 5 and 7 , von Willebrand factor , tissue plasminogen activator ( tPA ) , and plasminogen activator inhibitor ( PAI 1 ) ) in patients with heart failure . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To determine whether angiotensin converting enzyme inhibition by perindopril can reduce cardiac transforming growth factor beta 1 ( TGFbeta 1 ) and plasminogen activator inhibitor 1 ( PAI 1 ) and therefore control collagen accumulation in an animal model with the metabolic syndrome such as the obese Zucker rat ( OZR ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : The expression of uPA , tPA , urokinase receptor ( uPAR ) , plasminogen activator inhibitor 1 ( PAI 1 ) , and vitronectin was investigated by immunohistochemical staining , in addition to uPA , tPA and PAI 1 expression by in situ hybridization , in samples from eight chronic venous ulcers , five decubitus ulcers , five well granulating acute wounds and five normal skin samples . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This mechanism may also mediate , in large part , the increase in plasminogen activator inhibitor 1 ( PAI 1 ) observed in this syndrome . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
RESULTS : The plasma levels of fibrinogen , antithrombin 3 ( AT 3 ) , plasminogen activator inhibitor 1 ( PAI 1 ) , von Willebrand factor ( vWF ) activity and prothrombin time were found to be significantly increased in the type 2 diabetic patients compared with the healthy subjects . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Production of plasminogen activator inhibitor 1 ( PAI 1 ) by endothelial cells : differential responses to calcitriol and paricalcitol . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Among these are the genes encoding plasminogen activator inhibitor ( PAI 1 ) and hydroxysteroid sulfotransferase ( STA 2 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Because the signaling mechanisms activated by this peptide in the pulmonary vasculature are largely unknown , we investigated the role of hU 2 in the activation of NADPH oxidase and the control of redox sensitive kinase pathways , expression of plasminogen activator inhibitor 1 ( PAI 1 ) , and proliferation in pulmonary artery smooth muscle cells ( PASMCs ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Transforming growth factor beta 1 ( TGF beta 1 ) stimulates expression of plasminogen activator inhibitor type 1 ( PAI 1 ) , a serine protease inhibitor ( SERPIN ) important in the control of stromal barrier proteolysis and cell to matrix adhesion . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Their protein or activity levels , plus those of plasminogen / plasmin , tissue inhibitor of metalloproteinase 1 , 2 , 4 ( TIMP 1 , 2 , 4 ) and plasminogen activator inhibitor 1 ( PAI 1 ) were analyzed in tissue conditioned media by Western blot , ELISA and / or zymography . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The quantitative real time RT PCR revealed that the expression of plasminogen activator inhibitor 1 ( PAI 1 ) gene increased when HUVEC were exposed to Dex and TNF alpha , respectively , and the corresponding augmentation of its protein expression was confirmed by immunohistochemistry . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In recent years , the importance of the plasminogen activator ( PA ) and its adjustment factor , plasminogen activator inhibitor 1 ( PAI 1 ) , in the prevention of atherosclerosis has gradually received recognition . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma levels of the inflammatory marker C reactive protein ( CRP ) were determined at basal conditions , and the fibrinolytic parameters tissue type plasminogen activator ( t PA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) were measured at basal conditions and after a standardized venous occlusion ( VO ) of the forearm . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The plasminogen activator inhibitor ( PAI 1 ) 4G / 5G promoter polymorphism and PAI 1 levels in ischemic stroke . ^^^ High levels of plasminogen activator inhibitor type 1 ( PAI 1 ) have been implicated as a risk factor for cardiovascular disease , but its precise role remains controversial . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To investigate the influence of peroxisome proliferator activated receptor alpha activators on plasminogen activator inhibitor 1 ( PAI 1 ) expression in HepG 2 cells and the mechanism possibly involved . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Additionally , Abeta 1 42 reduced TGF beta 1 induced increase in plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) , a 45 kDa serine proteinase inhibitor with reactive site peptide bond Arg 345 Met346 , is the main physiological plasminogen activator inhibitor . ^^^ Besides its role in regulating hemostasis , PAI 1 plays a role in several biological processes dependent on plasminogen activator or plasmin activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Genes such as gelatinase A ( MMP 2 ) , cathepsin L , tissue inhibitor metalloproteinases 2 ( TIMP 2 ) and 3 ( TIMP 3 ) , plasminogen activator inhibitor 1 ( PAI 1 ) , tissue type plasminogen activator ( tPA ) , urokinase plasminogen activator ( tPA ) , endothelin 1 , calponin , carboxypeptidase D and calponin acidic were down regulated . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the present study we investigated the relationship between patient outcome and levels of VEGF , urokinase plasminogen activator ( uPA ) and plasminogen activator inhibitor 1 ( PAI 1 ) in tumor cytosols of 196 node negative primary invasive breast cancer patients who did not receive any adjuvant therapy . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
His characteristic abnormalities of fibrinolysis included shortened euglobulin clot lysis time , low plasminogen activator inhibitor 1 ( PAI 1 ) activity and antigen in plasma , which were remarkably reduced to only about 10 % of control . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) stimulates human corneal epithelial cell adhesion and migration in vitro . ^^^ In addition to its role as an inhibitor of urokinase plasminogen activator ( uPA ) , plasminogen activator inhibitor 1 ( PAI 1 ) is hypothesized to regulate epithelial cell adhesion and migration . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
RESULT ( S ) : In patients with endometriosis and adhesions , significantly higher peritoneal fluid concentrations were found for plasminogen activator inhibitor 1 ( PAI 1 ) , tissue plasminogen activator ( tPA ) , and plasminogen , compared with patients with endometriosis but without adhesions . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The aim of the study was to assess the effect of cardiothoracic surgery on the dynamics of plasminogen , D dimers and plasminogen activator inhibitor ( PAI 1 ) during the first 24 h after surgery . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To determine whether the increased concentration in blood of total tissue type plasminogen activator ( t PA ) , accompanying increased plasminogen activator inhibitor type 1 ( PAI 1 ) seen with diabetes reflects increased free t PA and hence activity or simply increased t PA complexed with PAI 1 , we measured each in 39 people with type 2 diabetes . ^^^ BACKGROUND : Type 2 diabetes is known to be associated with increased concentrations in blood of total tissue type plasminogen activator ( t PA ) [ free t PA plus t PA complexed with plasminogen activator inhibitor type 1 ( PAI 1 ) ] and PAI 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
IL 1beta concentrations in cultured monocytes and PAI 1 ( Plasminogen Activator Inhibitor ) plasma levels were measured using the ELISA method . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) ] . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : Adopting the prospective , randomized controlled method to observe the coagulant fibrinolysis related indexes , including tissue plasminogen activator ( t PA ) , plasminogen activator inhibitor 1 ( PAI 1 ) , von Willebrand factor ( vWF ) , antithrombin 2 ( AT 3 ) and fibrinogen ( FIB ) , in CHD patients after PCI , there were 26 patients in the treated group treated by TGC with Western medicine and 26 in the control group treated by Western medicine alone . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
It is thought that plasminogen activator inhibitor 1 ( PAI 1 ) functions in the RAS , in addition to involvement in thrombotic risk and fibrosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The secondary end points were : changes in vascular cells adhesion molecule 1 ( VCAM 1 ) , von Willebrand factor ( vWF ) , fibrinogen and plasminogen activator inhibitor 1 ( PAI 1 ) circulating levels and of urinary albumin excretion rate ( AER ) as well ; 129 patients were randomized : 66 in the candesartan group and 63 in the enalapril group , 118 of them completed the scheduled 24 week treatment period . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
INTRODUCTION : The purpose of this study was to estimate , in patients undergoing cardiopulmonary bypass ( CPB ) , the in vivo rates of tissue plasminogen activator ( tPA ) and plasminogen activator inhibitor 1 ( PAI 1 ) secretion , plasmin generation , fibrin degradation , and plasmin inhibition by aprotinin versus antiplasmin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is a key negative regulator of the fibrinolytic system . ^^^ In a chromogenic substrate based urokinse ( uPA ) / PAI 1 assay and a tissue type plasminogen activator ( tPA ) mediated clot lysis assay , ZK 4044 inhibited human PAI 1 activity with IC 50 values of 644+ / 255 and 100+ / 90 nM , respectively . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Conflicting data exist concerning the role of plasminogen activator inhibitor 1 ( PAI 1 ) and its predictive value for restenosis . ^^^ Blood samples were taken at baseline and up to 7 days after PCI and PAI 1 active antigen and tissue plasminogen activator ( t PA ) antigen were determined . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In them , and in an equal number of controls , plasma levels of immunoreactive tissue plasminogen activator ( tPA ) , plasminogen activation inhibitor 1 ( PAI 1 ) , von Willebrand factor ( VWF ) , fibrinogen , D dimer and CRP were measured . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Effects of perindopril treatment on hemostatic function in patients with essential hypertension in relation to angiotensin converting enzyme ( ACE ) and plasminogen activator inhibitor 1 ( PAI 1 ) gene polymorphisms . ^^^ In order to elucidate the role of genetic factors , we studied hemostasis in patients with untreated and treated HT and correlated the results with ACE I / D and plasminogen activator enhibitor 1 ( PAI 1 ) 4G / 5G gene polymorphisms . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma levels of von Willebrand factor , D dimer , plasminogen activator inhibitor type 1 ( PAI 1 ) , tissue plasminogen activator activity , tissue factor pathway inhibitor and activated factor 7 ( FVIIa rTF ) were measured . ^^^ D dimer levels ( 661+ / 80 ng / ml ) and tissue plasminogen activator activity levels ( 2 . 04+ / 0 . 14 IU / ml ) were also higher than in controls : 395+ / 99 ng / ml and 1 . 6+ / 0 . 1 IU / ml , respectively ( P < 0 . 05 ) , whereas levels of PAI 1 , FVIIa rTF and tissue factor pathway inhibitor were similar in both groups . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) modifies the formation of aggressive fibromatosis ( desmoid tumor ) . ^^^ We found that plasminogen activator inhibitor 1 ( PAI 1 ) was upregulated fourfold in aggressive fibromatosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is produced by adipose tissue , and elevated PAI 1 levels in plasma are a risk factor in the metabolic syndrome . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Because only some coronary risk factors have been evaluated for an association with plasma plasminogen activator inhibitor 1 ( PAI 1 ) activity , this cross sectional study examined the association between 27 coronary risk factors and PAI 1 in 24 healthy persons without coronary heart disease ( control persons ) and 22 patients who had survived myocardial infarction ( cases ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen Activator Inhibitor 1 ( PAI 1 ) is a marker of this state . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To examine a possible association between the smallpox vaccine and postvaccination ischemic events , we investigated alterations in levels of prothrombotic proteins ( plasminogen activator inhibitor type 1 [ PAI 1 ] and soluble CD 40 ligand [ sCD40L ] ) in recently vaccinated individuals . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Several cell biological studies have shown that the invasiveness of different malignant tumors ( breast , renal , prostate , gastric , ovarian cancers ) depends at least in part on the urokinase type plasminogen activator ( uPA ) and its inhibitor PAI 1 . uPA converts plasminogen into plasmin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Insulin also enhanced the formation of IL 8 and plasminogen activation inhibitor 1 ( PAI 1 ) , but not that of IL 6 by adipocytes although having little effect on that of IL 6 or PAI 1 by adipose tissue explants . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A . ) , plasminogen activity ( Berichrom Plasminogen Behring ) , tissue plasminogen activator antigen level ( t PA ) ( Imulyse t PA Biopool ) , plasminogen activator inhibitor 1 level ( PAI 1 ) ( Imulyse PAI 1 Biopool ) , plasmin alpha 2 antiplasmin complex level ( PAP ) ( Enzygnost PAP micro ) oraz D dimer level ( Vidas D Dimer bioMrieux S . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The levels of fibrinogen , von Willebrand factor antigen ( VWF : Ag ) and plasminogen activator inhibitor type 1 activity ( PAI 1 ) were measured preoperatively , and 2 weeks , 4 weeks and 3 months postoperatively . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Endothelial function was assessed by flow mediated dilatation ( FMD ) of the brachial artery and plasma concentration of von Willebrand factor ( vWF ) and plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NSO produced a concentration dependent inhibition of tissue type plasminogen activator ( t PA ) , urokinase type plasminogen activator ( u PA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The type and amount of dietary fat has been shown to alter thromboxane A 2 production and platelet aggregation , bleeding time , factor 7 , fibrinogen , tissue plasminogen activator ( t PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To determine the levels of plasminogen activator inhibitor 1 ( PAI 1 ) and total protein in the aqueous humor of patients with glaucoma vs those without glaucoma . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : C reactive protein ( CRP ) , fibrinogen and plasminogen activating inhibitor 1 ( PAI 1 ) are acute phase reactants ( APRs ) ; and high levels are indicative of physiologic inflammatory responses . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is a serpin class protease inhibitor that plays a central role in the regulation of vascular function and tissue remodeling by modulating thrombosis , inflammation , and the extracellular matrix . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the present study , we tested the hypothesis that loss of the primary inhibitor of uPA , plasminogen activator inhibitor 1 ( PAI 1 ) , would improve muscle regeneration . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Reverse transcription polymerase chain reaction assessed mRNA levels of eNOS , tPA , and the endogenous plasminogen activator inhibitor PAI 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In white non Hispanic children , beta 2 adrenergic receptor gln27glu was associated with CP risk ; in Hispanic children , plasminogen activator inhibitor 1 ( PAI 1 ) 4G ( 675 ) 5G and G11053T were associated with risk of CP . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : We sought to determine the etiologic mechanism of proinflammatory cytokine , interleukin 6 ( IL 6 ) , and statin as regulators of synthesis of plasminogen activator inhibitor 1 ( PAI 1 ) , the physiological fibrinolysis inhibitor and an acute phase reactant . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Overexpression of KLF 2 strongly induced thrombomodulin ( TM ) and endothelial nitric oxide synthase ( eNOS ) expression and reduced plasminogen activator inhibitor 1 ( PAI 1 ) expression . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Levels of plasminogen ( PLG ) , tissue plasminogen activator ( t PA ) , plasminogen activator inhibitor 1 ( PAI 1 ) and D dimer were determined and compared . ^^^ RESULTS : The activity of t PA in NAFL patients was significantly lower than that in the control group ( P < 0 . 05 ) , and PLG and PAI 1 were significantly higher than those in the control group ( P < 0 . 05 ) . ^^^ In respect to the TCM Syndrome typing , in patients of PSS , t PA was significantly lower and PLG , PAI 1 were significantly higher than those in patients of non PSS ( P < 0 . 05 or P < 0 . 01 ) , while D dimer was insignificantly different between patients of the two Syndrome types ( P > 0 . 05 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Recently , several experimental data have implicated the plasminogen activator inhibitor 1 ( PAI 1 ) in tumor angiogenesis in murine systems . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Thrombogenic prevalence can be normalized by physical activity at many steps of the hemostasis : activated fibrinolysis , more favorable blood viscosity , lower plasminogen activator inhibitor ( PAI 1 ) level , decreased platelet activity . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
RT PCR assay for urokinase type plasminogen activator ( uPA ) , its cellular receptor ( uPAR ) , tissue type plasminogen activator ( tPA ) , plasminogen activator inhibitor type 1 ( PAI 1 ) , and tumor necrosis factor ( TNF ) alpha was performed to assess the cecal tissue . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Accumulative data have demonstrated that plasminogen activator inhibitor 1 ( PAI 1 ) plays an important role in the extracellular matrix metabolism ; however , the involvement of PAI 1 in scleroderma has not been fully elucidated . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : Type 2 diabetes and insulin resistance have been associated with several cardiac features including diastolic heart failure , impaired ventricular function , perimicrovascular fibrosis and increased expression of plasminogen activator inhibitor type 1 ( PAI 1 ) in coronary arterial walls . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
RESULTS : Plasminogen activator inhibitor 1 ( PAI 1 ) was identified as an overexpressed gene in a PGP9 . 5 expressed esophageal squamous cancer cell line . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Testosterone does not adversely affect fibrinogen or tissue plasminogen activator ( tPA ) and plasminogen activator inhibitor 1 ( PAI 1 ) levels in 46 men with chronic stable angina . ^^^ Measurements of free , total and bioavailable testosterone , luteinising hormone ( LH ) and follicle stimulating hormone ( FSH ) , estradiol , plasminogen activator inhibitor 1 ( PAI 1 ) , fibrinogen , tissue plasminogen activator ( tPA ) and full blood count were made at 0 , 6 and 14 weeks . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Penetration of the villi into the tissues is controlled by plasminogen activator inhibitors plasminogen activator inhibitor 1 ( PAI 1 ) and plasminogen activator inhibitor 2 ( PAI 2 ) , mainly by PAI 2 . ^^^ CONCLUSION : Disturbance of balance between plasminogen activator and their inhibitors ( PAI 1 and PAI 2 ) in placenta and myometrium can lead to the formation of placenta accreta . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Furthermore , pro inflammatory cytokines and plasminogen activator inhibitor 1 ( PAI 1 ) levels have also been shown to be decreased with alpha tocopherol supplementation in vivo . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
There was a tendency for the prevalence of poorly controlled and masked hypertension to improve to the well controlled category in response to intensive therapy ( p=0 . 0625 , by Wilcoxon ' s signed rank test ) . 3 ) The plasma concentration of plasminogen activator inhibitor ( PAI 1 ) / tissue plasminogen activator ( t PA ) complex ( total PAI 1 complex ) was significantly decreased after intensive therapy ( 17 . 3+ / 7 . 8 ng / ml vs . 13 . 5+ / 4 . 6 ng / ml , n=28 , p < 0 . 01 by paired t test ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Additionally ; fibrinogen , plasminogen , plasminogen activator inhibitor ( PAI 1 ) , tissue plasminogen activator ( t PA ) and von Willebrand factor ( vWF ) levels were measured to determine the procoagulant activity . ^^^ Additionally ; procoagulant activity assessed by fibrinogen , plasminogen , PAI 1 , t PA and vWF levels was similar in both groups . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In cell based assays , SB 525334 ( 1 microM ) blocked TGF beta 1 induced phosphorylation and nuclear translocation of Smad2 / 3 in renal proximal tubule cells and inhibited TGF beta 1 induced increases in plasminogen activator inhibitor 1 ( PAI 1 ) and procollagen alpha 1 ( 1 ) mRNA expression in A 498 renal epithelial carcinoma cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The pathogenesis of this syndrome is driven by the transcriptional response to the oncogene , including prominent upregulation of plasminogen activator inhibitor type 1 ( PAI 1 ) and cyclooxygenase 2 ( COX 2 ) genes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the blood plasma obtained in the couple of time points in the perioperative period the determinations were done as followed : the concentrations of von Willebrand factor antigen ( vWf Ag ) , tissue plasminogen activator antigen ( t PA Ag ) , antigen of plasminogen activator inhibitor type 1 ( PAI 1 Ag ) and fibrinogen . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Resulting growth kinetics , integrin expression , invasiveness , TGF beta mediated activation of human plasminogen activator inhibitor type 1 ( PAI 1 ) promoter and Smad expression were determined . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This review summarises the history , focuses on evidence for dietary C 18 unsaturated fatty acids as important determinants of factor 7 ( FVII ) activation and plasminogen activator inhibitor type 1 ( PAI 1 ) levels , and discusses possible underlying mechanisms involving ATP binding cassette ( ABC ) transporters and peroxisome proliferator activated receptors . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Here we examined whether the plasminogen activator inhibitor 1 and 2 ( PAI 1 and PAI 2 ) mRNA , endogenous inhibitors of tPA and uPA , are induced in the DRG following sciatic nerve transection . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The combination of hypertriglyceridemia , glucose intolerance and inflammation is linked with increased production of the primary inhibitor of endogenous thrombolysis , plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : Tissue type plasminogen activator deficient ( tPA ( / ) ) , urokinase type plasminogen activator deficient ( uPA ( / ) ) , plasminogen activator inhibitor 1 deficient ( PAI 1 ( / ) ) , alpha 2 antiplasmin deficient ( alpha 2 AP ( / ) ) mice , and their wild type counterparts were used . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In simple binary logistic regression , atherosclerotic plaques were associated with age , IMT CCA , smoking , and the levels of sICAM 1 , sE selectin , interleukin 2 soluble receptor alpha ( IL 2sRalpha ) , plasminogen activator inhibitor 1 ( PAI 1 ) mass , cholesterol , LDL cholesterol , and the LDL / high density lipoprotein ( HDL ) ratio . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In this study , we investigated the role of AT ( 1 ) receptor agonistic autoantibody ( AT 1 AA ) regarding interleukin 6 ( IL 6 ) and plasminogen activator inhibitor 1 ( Pai 1 ) secretion in human mesangial cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This effect of activated macrophages on trophoblast invasiveness was paralleled by abrogation of a 55 kDa caseinolytic activity corresponding to prourokinase plasminogen activator ( pro uPA ) and an increased secretion of plasminogen activator inhibitor 1 ( PAI 1 ) , as determined by gel zymography and ELISA , respectively . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The liver fat content is significantly correlated with variables relating to obesity ( body mass index [ BMI ] , body weight , fat mass , waist to hip ratio , visceral fat area , subcutaneous fat area , and serum triglyceride ) , insulin resistance ( fasting plasma insulin and homeostasis model assessment of insulin resistance [ HOMA IR ] ) , adipocytokines ( serum plasminogen activator inhibitor 1 [ PAI 1 ] and leptin ) , and serum cholinesterase , but not CT liver / spleen ratio , which is correlated only with fasting plasma glucose , BMI , and HOMA IR . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Serum CRP , leptin , adiponectin , glucose , insulin , lipid profile , plasminogen activator inhibitor 1 ( PAI 1 ) and fibrinogen were all measured . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
CEE decreased the antigen levels of tissue plasminogen activator ( t PA ) from 8 . 8 to 6 . 8 U / ml ( p < 0 . 001 ) , and of plasminogen activator inhibitor ( PAI 1 ) from 30 . 8 to 21 . 6 U / ml ( p < 0 . 010 ) , whereas raloxifene had no significant effect on either t PA , from 9 . 6 to 9 . 2 U / ml ( p = 0 . 235 ) or PAI 1 antigen levels , from 32 . 1 to 30 . 4 U / ml ( p = 0 . 538 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) has been implicated as a contributing risk factor for cardiovascular disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Aging and plasminogen activator inhibitor 1 ( PAI 1 ) regulation : implication in the pathogenesis of thrombotic disorders in the elderly . ^^^ One of the important key genes for aging associated thrombosis is plasminogen activator inhibitor 1 ( PAI 1 ) , a principal inhibitor of fibrinolysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The aim of this study was to investigate the behaviors of plasminogen activator inhibitor type 1 ( PAI 1 ) , the inhibitor of fibrinolysis ; and thromboxane A 2 and 6 keto PGF 1 alpha , the products of endoperoxides , in 16 patients affected with clonal thrombocytemia as compared with 16 patients with reactive thrombocytosis and 15 normal controls . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) 4G / 5G and Factor 13 Val134Leu variants were compared between maternal and newborn cases and controls . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Its effects on ROS production , AP 1 activity , plasminogen activator inhibitor 1 ( PAI 1 ) gene expression , and cellular proliferation and migration were measured in response to high glucose and angiotensin 2 ( Ang 2 ) concentrations , two major factors in the pathogenesis of atherosclerosis in patients with diabetes and hypertension . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To investigate whether separated and cultured endometriotic and endometrial stromal and epithelial cells release urokinase plasminogen activator ( uPA ) , plasminogen activator inhibitor 1 ( PAI 1 ) , and soluble plasminogen activator receptor ( suPAR ) antigens in vitro . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVES : To investigate whether tissue expression of plasminogen activator inhibitor type 1 ( PAI 1 ) is increased in the fibrotic plaque of human Peyronie ' s disease ( PD ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Both the peripheral biological clock and the renin angiotensin system regulate mRNA expression of plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : Adipose tissue is a prominent source of plasminogen activator inhibitor 1 ( PAI 1 ) , the primary physiological inhibitor of plasminogen activation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is a component of extracellular matrix ( ECM ) and target gene of transforming growth factor beta ( TGF beta ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : Plasminogen activator inhibitor 1 ( PAI 1 ) plays an important role in remodeling of extracellular matrix ( ECM ) in the glomeruli . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : Vascular endothelial function , plasma plasminogen activator inhibitor 1 ( PAI 1 ) , vascular cell adhesion molecule 1 ( VCAM 1 ) and insulin active index ( IAI ) were measured in 57 FDR and 31 controls . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Although plasminogen activator inhibitor 1 ( PAI 1 ) is one of the primary regulators of the fibrinolytic system , it also has dramatic effects on cell adhesion , detachment and migration . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Thus , the generation of plasmin involves the pro enzyme plasminogen , the urokinase type plasminogen activator uPA and its pro enzyme pro uPA , the uPA inhibitor PAI 1 , the cell surface uPA receptor uPAR , and the plasmin inhibitor alpha ( 2 ) antiplasmin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Recent studies , mainly in adults receiving HSCT , have identified an increase in the plasminogen activator inhibitor 1 ( PAI 1 ) as a possible marker of VOD . ^^^ The 6 children with VOD ( 9 . 84 % ) had an early and significant increase in PAI 1 antigen and activity ( p < 0 . 0001 ) , t PA antigen ( p < 0 . 0001 ) and D dimer ( p < 0 . 01 ) levels , and a decrease in plasminogen , alpha 2 antiplasmin and PT emerged 2 ( + / 1 ) days before the clinical diagnosis of VOD by comparison with mean post HSCT values in the non VOD patients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The G20210A prothrombin gene mutation and the plasminogen activator inhibitor ( PAI 1 ) 5G / 5G genotype are associated with early onset of severe preeclampsia . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
However , fluorescence activated cell sorting analysis revealed a 25 % increase in cell surface u PAR in hr sMTf treated HMEC 1 , whereas the binding of the urokinase type plasminogen activator ( u PA ) * plasminogen activator inhibitor 1 ( PAI 1 ) complex is decreased . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Using this effect , we have measured the enthalpy ( DeltaH ) of loop cleavage and insertion for plasminogen activator inhibitor 1 ( PAI 1 ) as 38 kcal / mol . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Impaired fibrinolysis and massive elevation of the plasminogen activator inhibitor 1 ( PAI 1 ) is a characteristic feature of meningococcal sepsis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To further evaluate the mechanism , we performed another clinical study focusing on the change in plasma plasminogen activator inhibitor 1 ( PAI 1 ) levels among cyclosporine ( CyA ) treated renal allograft recipients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS AND RESULTS : Troponin l , soluble P selectin , von Willebrand factor ( vWF ) , fibrinogen , plasminogen , plasminogen activator inhibitor 1 ( PAI 1 ) and tissue plasminogen activator ( t PA ) concentrations of 202 consecutive patients with non ST elevation acute coronary syndrome ( NSTE ACS ) were measured at the time of admission . ^^^ In these patients fibrinogen ( p < 0 . 001 ) , plasminogen ( p < 0 . 001 ) and PAI 1 ( p < 0 . 026 ) concentrations were higher and t PA concentrations were lower ( p < 0 . 013 ) and all these parameters correlated with P selectin concentrations ( p < 0 . 001 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is a major physiological regulator of the fibrinolytic system and is thought to promote vascular diseases . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Blood samples were analyzed for procoagulant factors ( prothrombin , factors 7 [ fVII ] , 8 [ fVIII ] , 9 [ fIX ] and 11 [ fXI ] , D dimer and von Willebrand factor [ vWf ] ) , anticoagulant factors ( antithrombin [ AT ] , total and free protein S , protein C and activated protein C [ APC ] resistance ) and fibrinolytic factors ( thrombin activatable fibrinolysis inhibitor [ TAFI ] and plasminogen activator inhibitor 1 [ PAI 1 ] ) , at baseline and at 6 months of treatment . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Thrombin and other proteases ( e . g . , coagulation factor Xa , tryptase ) upregulate protease activated receptor ( PAR ) synthesis and PAR activation promotes synthesis and expression of other proteins [ e . g . , tissue factor ( TF ) and plasminogen activator inhibitor 1 ( PAI 1 ) ] . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : Obesity is a metabolic disorder that is associated with increased plasminogen activator inhibitor 1 ( PAI 1 ) concentration in the circulation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Lp ( a ) , fibrinogen , plasminogen , PAI 1 and t PA levels were measured and C reactive protein ( CRP ) assays were performed on admission for all patients , and venous blood samples were drawn 12 and 24 h later for cTn 1 measurements . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We tested a novel , orally active inhibitor of plasminogen activator inhibitor 1 ( PAI 1 ) in a canine model of electrolytic injury . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) inhibits the activation of the plasminogen activator system , the latter being involved in cancer growth and dissemination . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The aim of this study was to investigate the changes in mRNA level of embryonic form of myosin heavy chain ( SMemb ) , endothelin 1 ( ET 1 ) and plasminogen activator inhibitor 1 ( PAI 1 ) , which are considered to be involved in the angiogenesis and atherosclerosis in diabetic blood vessels , in human umbilical vein endothelial cells ( HUVECs ) caused by high ambient glucose , and the effects of 2 aminophenoxazine 3 one ( Phx 3 ) , which was produced by the reaction of bovine hemoglobin with o aminophenol , on them . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVES : The aim of this case control study was to investigate a number of acquired and inherited thrombophilic risk factors [ antithrombin , protein C and S ; factor 5 ( FV ) Leiden , FII polymorphism ; lupus anticoagulant ( LA ) ; anticardiolipin ( aCL ) antibodies ; fasting homocysteine ( Hcy ) ; lipoprotein ( a ) ( Lp ( a ) ) ; plasminogen activator inhibitor 1 ( PAI 1 ) ] in addition to cardiovascular risk factors in patients with idiopathic SSHL ( ISSHL ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The proteinase inhibitor , type 1 plasminogen activator inhibitor ( PAI 1 ) , is a major regulator of the plasminogen activator system involved in plasmin formation and fibrinolysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : The plasma levels of the plasminogen activator inhibitor type 1 ( PAI 1 ) are consistently elevated in patients with sterile tissue injury , often accompanied by a systemic acute phase protein response . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
CLINICAL RELEVANCE : Elevated urokinase like plasminogen activator ( uPA ) and decreased plasminogen activator inhibitor 1 ( PAI 1 ) levels are predictors for restenosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tumour associated urokinase type plasminogen activator ( uPA ) and its inhibitor PAI 1 in normal and neoplastic tissues of patients with squamous cell cancer of the oral cavity clinical relevance and prognostic value . ^^^ The central role of the serine protease urokinase type plasminogen activator ( uPA ) and its inhibitor , the plasminogen activator inhibitor 1 ( PAI 1 ) , in tumour invasion and metastasis becomes more and more evident . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
DESIGN : In the present cross sectional study , eight SNPs of six genes involved in vascular function and homeostasis were analyzed by sequencing on chip using solid phase polymerase chain reaction on oligonucleotide microarrays in 728 white women : factor 5 ( F 5 ) Leiden G1691A , factor 2 ( F 2 ) prothrombin G20210A , plasminogen activator inhibitor 1 ( PAI 1 ) 4G / 5G , angiotensinogen ( AGT ) Met235Thr , endothelial nitric oxide synthase ( NOS 3 ) T768C and NOS 3 Glu298Asp , apolipoprotein E 1 ( APOE 1 ) Cys112Arg , and APOE 2 Arg158Cys . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
An unexpected role of plasminogen activator inhibitor type 1 ( PAI 1 ) in renal fibrosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : Progressive renal disease is characterized by the induction of plasminogen activator inhibitor 1 ( PAI 1 ) , suggesting that impaired activity of the renal plasmin cascade may play a role in renal fibrosis . ^^^ BACKGROUND : Plasminogen activator inhibitor 1 ( PAI 1 ) has been implicated in the pathogenesis of chronic kidney disease based on its up regulated expression and on the beneficial effects of PAI 1 inhibition or depletion in experimental models . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To evaluate the potential role of the uPAR / uPA / PAI 1 system in HIV induced blood brain barrier ( BBB ) disruption , CSF uPA dependent plasminogen activation ( PdPA ) was analyzed by casein zymography , and CSF protein levels of all three molecules were measured by ELISA . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is the main physiological inhibitor of tissue type ( t PA ) and urokinase type ( u PA ) plasminogen activator . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Whilst the plasma levels of many clotting factors including fibrinogen , FVII , FVIII , FXII , FXIII b subunit are elevated , the fibrinolytic system is relatively inhibited as a consequence of an increase in plasminogen activator inhibitor type 1 ( PAI 1 ) levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Two of the changes , amphiregulin and plasminogen activator inhibitor 1 ( PAI 1 ) , were confirmed by real time quantitative PCR ( QPCR ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Both n CRP and m CRP were incubated with human aortic endothelial cells ( HAEC ) and biological activities was tested by assaying for interleukin 8 ( IL 8 ) , plasminogen activator inhibitor 1 ( PAI 1 ) , cyclic GMP and prostaglandin F 1 alpha . n CRP significantly upregulated IL 8 at concentrations > or = 10 microg / mL while m CRP upregulated IL 8 only at concentrations of 50 microg / mL ( p < 0 . 05 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tumor necrosis factor ( TNF ) alpha , interleukin ( IL ) 1beta , IL 6 , IL 8 , macrophage inflammatory protein ( MIP ) 1beta , monocyte chemoattractant protein ( MCP ) 1 , plasminogen activator inhibitor type 1 ( PAI 1 ) and tissue type plasminogen activator ( tPA ) were measured using enzyme linked immunosorbent assays . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Increased plasminogen activator inhibitor 1 ( PAI 1 ) and decreased tissue plasminogen activator ( t PA ) activities lead to impaired fibrinolysis , which is critical for cardiovascular disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) and vitronectin are cofactors involved in pathological conditions such as injury , inflammation , and cancer , during which local levels of PAI 1 are increased and the active serpin forms complexes with vitronectin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 4G / 5G polymorphism in breast cancer patients and its association with tissue PAI 1 levels and tumor severity . ^^^ BACKGROUND : The plasminogen activator inhibitor type 1 ( PAI 1 ) 4G / 5G polymorphism may have significance for PAI 1 expression . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
C type natriuretic peptide ( CNP ) suppresses plasminogen activator inhibitor 1 ( PAI 1 ) in vivo . ^^^ OBJECTIVE : Elevated vascular plasminogen activator inhibitor 1 ( PAI 1 ) levels are associated with atherosclerosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The type 1 plasminogen activator inhibitor ( PAI 1 ) is the major physiologic regulator of the plasminogen activation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma P selectin antigen , tissue plasminogen activator ( tPA ) antigen and activity , and plasminogen activator inhibitor 1 ( PAI 1 ) activity were determined in 60 acute atherosclerotic stroke patients and matched control subjects . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In this study we provide evidence that mast cell derived exosomes induce plasminogen activator inhibitor type 1 ( PAI 1 ) expression in endothelial cells , detectable at the level of PAI 1 mRNA and protein synthesis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is an anti thrombolytic factor that also promotes tissue fibrosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Increased expression of plasminogen activator inhibitor 1 ( PAI 1 ) in adipose tissues is thought to contribute to both the cardiovascular and metabolic complications associated with obesity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We found increased expression of MMP 10 , 15 , 24 , 25 and 26 , urokinase plasminogen activator receptor ( uPAR ) and plasminogen activator inhibitor 1 ( PAI 1 ) , and the newly characterised serine proteases hepsin and matriptase 1 ( MTSP 1 ) in malignant tissue compared to benign prostate tissue . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The expression of plasminogen activator inhibitor 1 ( PAI 1 ) and tissue type plasminogen activator ( tPA ) protein in atrium was determined by Western Blot analysis and immunohistochemical staining . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We focused on the release of plasminogen activator inhibitor 1 ( PAI 1 ) from endothelial cells which has earlier been found to be significantly elevated in plasma of VOD patients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This study reports the stability of mRNA of type 1 plasminogen activator inhibitor ( PAI 1 ) , the major physiologic inhibitor of plasminogen activation , by deferoxamine aided iron deprivation , in PC 3 adenocarcinoma cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We demonstrate that KS cells and MVEC express the u PA receptor ( u PAR ) and release plasminogen activators and plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
One proteolytic system involved in these processes is the urokinase type plasminogen activator ( uPA ) system , which consists of uPA , uPA receptor ( uPAR ) and uPA inhibitors 1 and 2 ( PAI 1 and PAI 2 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The plasminogen activator ( PA ) system comprises the 2 serine proteases , urokinase PA ( uPA ) and tissue PA ( tPA ) , the 2 serpin inhibitors , PAI 1 and PAI 2 and the uPA receptor ( uPAR ; CD 87 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVES : To investigate the role of plasminogen activator inhibitor 1 ( PAI 1 ) in adipose tissue development and insulin metabolism . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the present study , we examined the effects of microinjections of plasminogen activator inhibitor 1 ( PAI 1 ) , tPA or plasmin into the NAc on morphine induced dopamine release , hyperlocomotion and anti nociceptive effects in ICR mice . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Several secretory proteins are synthesised in adipose tissue including leptin , resistin , adiponectin , tumor necrosis factor ( TNFalpha ) , angiotensinogen , adipsin , acylation stimulating protein , retinol binding protein ( RBP ) , interleukin ( IL ) 1b , IL 6 , IL 8 , IL 10 , plasminogen activator inhibitor 1 ( PAI 1 ) , fasting induced adipose factor , fibrinogen angiopoietin related protein , metallothionein , tissue factor ( TF ) , complement C 3 , fibronectin , haptoglobin , entactin / nidogen , collagen 6 alpha 3 , pigment epithelium derived factor ( PEDF ) , hippocampal cholinergic neurostimulating peptide ( HCNP ) , neutrophil gelatinase associated lipocalin ( NGAL ) and adiponutrin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Involvement of circadian clock gene Clock in diabetes induced circadian augmentation of plasminogen activator inhibitor 1 ( PAI 1 ) expression in the mouse heart . ^^^ Diabetes is associated with an excess risk of cardiac events , and one of the risk factors for infarction is the elevated levels of plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To explore the role of tissue plasminogen activator ( tPA ) activity and plasminogen activator inhibitor type 1 ( PAI 1 ) in survivors of a first myocardial infarction ( MI ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In week 16 , analysis included effects on systolic blood pressure , proteinuria , kidney function , glomerular and tubulointerstitial matrix protein accumulation , expression of transforming growth factor beta 1 ( TGF beta 1 ) , fibronectin and plasminogen activator inhibitor type 1 ( PAI 1 ) , macrophage infiltration , cell proliferation , basal and nitric oxide stimulated cGMP production as well as tubulointerstitial mRNA expression of alpha 1 and beta 1 soluble guanylate cyclase . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) was significant lower ( p < 0 . 05 ) in both groups after 12 months compared to the baseline values . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : Elevated levels of plasminogen activator inhibitor 1 ( PAI 1 ) are associated with myocardial infarction and stroke , especially in patients with diabetes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
During the course of screening for the agents that activate transforming growth factor beta ( TGF beta ) signaling cascade , onnamide A and theopederin B , heterocyclic compounds related to mycalamides from a marine sponge , were found to induce plasminogen activator inhibitor 1 ( PAI 1 ) promoter derived gene expression in Mv1Lu cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is a key molecule that regulates turnover of the extracellular matrix . ^^^ Our results on the control of PAI 1 gene expression by MITF isoforms , TGF beta 1 and activin A suggest that discrete regulation of the plasminogen activator system occurs in a cell type specific manner . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Along with these transrepressive activities RU 24858 , RU 24782 and RU 40066 displayed similar transactivation potentials as indicated by induction of the glucocorticoid inducible mouse mammary tumor virus ( MMTV ) reporter gene and by induced expression level of plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This study attempted to verify the existence of a relationship between SOX documented by Cu / Zn superoxide dismutase ( Cu / Zn SOD ) and fibrinolysis analyzed by tissue type plasminogen activator ( tPA ) , urokinase type plasminogen activator ( uPA ) , plasminogen activator inhibitor 1 ( PAI 1 ) and plasmin / antiplasmin ( PAP ) complexes in dialysis patients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tibolone significantly reduced plasma plasminogen activator inhibitor type 1 ( PAI 1 ) antigen levels from baseline values ( P=0 . 004 ) , compared with L HT showing no changes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Insulin like growth factor 1 ( IGF 1 ) and plasminogen activator inhibitor 1 ( PAI 1 ) appear to play a crucial role in a number of processes associated with growth and tissue remodelling . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The plasminogen activation system in skeletal muscle regeneration : antagonistic roles of urokinase type plasminogen activator ( uPA ) and its inhibitor ( PAI 1 ) . ^^^ Skeletal muscle regeneration induced by injury has been analyzed in urokinase type plasminogen activator ( uPA ) , tissue type plasminogen activator ( tPA ) , plasminogen ( Plg ) and plasminogen activator inhibitor 1 ( PAI 1 ) deficient mice and has demonstrated profound effects of these molecules on the fibrotic state and the inflammatory response , which contribute to muscle repair . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The cell associated fibrinolytic system ( urokinase type plasminogen activator , uPA ; uPA receptor , uPAR ; plasminogen activator inhibitor type 1 , PAI 1 ) is pivotal in cell invasion and proliferation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Here , the effect of plasminogen activator inhibitor 1 ( PAI 1 ) , an endogenous inhibitor of t PA , on ischemic infarct volume was studied . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have begun to investigate the expression of a primary inhibitor of fibrinolysis , plasminogen activator inhibitor 1 ( PAI 1 ) , in association with tissue thrombosis , using restraint stressed obese mice . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The aims of this study were to investigate the gene expression of fibrinolytic factors urokinase plasminogen activator ( uPA ) and plasminogen activator inhibitor 1 ( PAI 1 ) in the articular cartilage of rabbit temporomandibular joint ( TMJ ) with disc displacement ( DD ) and to probe the relationship between fibrinolytic activity and cartilage remodeling . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Cardiovascular risk markers ( highly sensitive C reactive protein [ hs CRP ] and plasminogen activator inhibitor 1 [ PAI 1 ] ) were measured at baseline and end point . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
As a marker of hemostatic system fibrinogen , tissue plasminogen activator ( tPA ) , and plasminogen activator inhibitor 1 ( PAI 1 ) levels were measured initially , and after 1 and 6 months of therapy . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We synthesized and evaluated a novel series of 2 carboxylic acid indole based inhibitors of plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Hypertension is associated with decreased fibrinolytic potential , mainly expressed as elevated plasma plasminogen activator inhibitor type 1 ( PAI 1 ) levels , and increased platelet aggregability , which may account in part for the increased risk of atherosclerosis and its clinical complications in hypertensive patients . ^^^ Scarce and conflicting data exist about the effects of diuretics and beta adrenoceptor antagonists on the fibrinolytic system , whereas ACE inhibitors have generally been reported to improve the fibrinolytic balance by decreasing plasma PAI 1 levels , calcium channel antagonists have been shown to increase tissue plasminogen activator ( tPA ) activity , and angiotensin 2 type 1 ( AT ( 1 ) ) receptor antagonists seem to exert neutral effects . beta Adrenoceptor antagonists , calcium channel antagonists , and AT ( 1 ) receptor antagonists have been reported to exert anti aggregatory effects on platelets , while contrasting data exist about the influence of ACE inhibitors . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Here , we report that prostate carcinoma cells LNCaP and PC 3 autoactivate latent full length PDGF D into its active form under serum independent conditions and that this autoactivation is inhibited by PAI 1 , a urokinase plasminogen activator ( uPA ) / tissue plasminogen activator ( tPA ) inhibitor . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We measured body fat distribution as well as plasminogen activator inhibitor 1 ( PAI 1 ) concentration and factor 8 ( fVIII ) activity at 8 : 00 am and 8 : 00 pm in 45 premenopausal women with MDD vs 28 healthy controls ( age , 37 + / 6 . 8 vs 35 + / 6 . 5 ; weight [ kg ] , 75 . 3 + / 17 . 2 vs 67 . 9 + / 10 . 2 ; mean + / SD ] participating in a prospective study of bone turnover , the POWER Study . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is the major physiological inhibitor of tissue type plasminogen activator ( tPA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Increased plasminogen activator inhibitor type 1 ( PAI 1 ) levels are observed in endothelial cells stimulated by tumour necrosis factor alpha ( TNFalpha ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To evaluate the role of factor 5 Leiden , prothrombin G20210A polymorphism , plasminogen activator inhibitor type 1 ( PAI 1 ) 4G / 5G polymorphism , PAI 1 , homocysteine , and lipoprotein ( a ) ( Lp ( a ) ) in the occurrence of major adverse cardiac events ( MACE ) in patients with acute coronary syndromes who underwent coronary stenting . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Importantly , the bactericidal properties of uPA are associated with the serine protease domain of the molecule but are not dependent on its plasminogen activation potential and can not be inhibited by plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : Extracellular fibrinolysis , controlled by the cell associated fibrinolytic system ( urokinase plasminogen activator , uPA ; uPA receptor , uPAR ; plasminogen activator inhibitor type 1 , PAI 1 ) , is involved in cartilage damage generation and in rheumatoid arthritis ( RA ) synovitis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Starting at 4 h postexposure , pulmonary damage was accompanied by persistently increased gene expressions of tissue factor ( TF ) and plasminogen activator inhibitor 1 ( PAI 1 ) , but not thrombomodulin ( TM ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fibrinolytic activity was determined by assaying tissue plasminogen activator ( TPA ) and plasminogen activation inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In addition , uPA receptor ( uPAR ) and plasminogen activator inhibitors ( PAIs ) , composed of PAI 1 and 2 , are also known to affect such activities . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : Plasminogen activator inhibitor type 1 ( PAI 1 ) is considered to be the main inhibitor of fibrinolysis in sepsis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
AT therapy , especially at high doses , has been shown to decrease the release of proinflammatory cytokines , the chemokine IL 8 and plasminogen activator inhibitor 1 ( PAI 1 ) levels as well as decrease adhesion of monocytes to endothelium . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We evaluated the effects of tibolone and its metabolites on tissue factor ( TF ) and plasminogen activator inhibitor type 1 ( PAI 1 ) expression in human endometrial stromal cells ( HESCs ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Urokinase type plasminogen activator ( uPA ) and plasminogen activator inhibitor 1 ( PAI 1 ) protein levels were not significantly different from sham over time ; however , the ratio of uPA to PAI 1 was decreased through 8 days . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : Chronic hypoxia has been newly proposed as a common mechanism of tubulointerstitial fibrosis in the progression of various chronic inflammatory renal diseases , where plasminogen activator inhibitor 1 ( PAI 1 ) plays an important role in the accumulation of extracellular matrix ( ECM ) through inhibition of plasmin dependent ECM degradation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Endotoxin ( lipopolysaccharide ( LPS ) ) , used as a standardized stimulus to define brain specific inflammation induced change , amplified pericyte induced enhanced release of the tPA inhibitor plasminogen activator inhibitor 1 ( PAI 1 ) ; the latter was released by endothelial cells first cocultured with pericytes and then incubated with LPS in the absence of pericytes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND AND PURPOSE : Impaired fibrinolytic function secondary to elevated plasminogen activator inhibitor 1 ( PAI 1 ) levels has been implicated in ischemic stroke . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
C reactive protein ( CRP ) and plasminogen activator inhibitor type 1 ( PAI 1 ) were also analyzed . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor type 1 ( PAI 1 ) in blood and tissue extracts of patients with non small cell lung cancer ] . ^^^ The aim of the present study was to evaluate plasminogen activator inhibitor type 1 ( PAI 1 ) in plasma and tumor extracts in patients with non small cell lung cancer ( NSCLC ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Serial blood specimens were obtained for pharmacokinetics and levels of urokinase plasminogen activator ( uPA ) , uPA receptor ( uPAR ) , and plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We examined the effect of PGE 1 on the expression of plasminogen activator inhibitor 1 ( PAI 1 ) mRNA induced by tumor necrosis factor alpha ( TNF alpha ) in human mesangial cells , because PAI 1 is one of major factors for the progression of glomerulosclerosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The role of hepatic type 1 plasminogen activator inhibitor ( PAI 1 ) during murine hemorrhagic shock . ^^^ A profound increase in plasminogen activator inhibitor type 1 ( PAI 1 ) mRNA was observed using hepatic mRNAs from C57Bl / 6 mice after HS , both with and without resuscitation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : Plasma biomarkers of inflammation [ fibrinogen , hs C reactive protein ( hs CRP ) ] and endothelial dysfunction [ von Willebrand factor ( 5 WF ) , intercellular adhesion molecule 1 , plasminogen activator inhibitor 1 ( PAI 1 ) activity ] were measured in 88 non smoking young patients with Type 1 diabetes without clinical macrovascular disease and in 40 healthy controls . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This study tests the hypothesis that spironolactone influences plasminogen activator inhibitor 1 ( PAI 1 ) concentrations through mineralocorticoid receptor antagonism rather than through changes in potassium . ^^^ Only spironolactone significantly decreased the molar ratio of PAI 1 to tissue type plasminogen activator ( t PA ) in hypertensive subjects . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
PURPOSE : To report an association between spontaneous subhyaloidal hemorrhage and severe plasminogen activator inhibitor 1 ( PAI 1 ) deficiency . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The proteolytic activities of these proteins were counterbalanced by ( 1 ) their expression as zymogens ( proMMP 9 , proMMP 14 ) , ( 2 ) the expression of their natural inhibitors , tissue inhibitors of metalloproteinases 1 and 2 and plasminogen activator inhibitor 1 ( PAI 1 ) , or ( 3 ) the addition of plant protein hydrolysates to the culture medium , acting as a nonspecific source of TPPII inhibitors . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Among them , fibronectin , Mac 2 binding protein ( Mac 2 BP ) , and plasminogen activator inhibitor 1 ( PAI 1 ) were further confirmed by Western blot analysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Effects of LDL glycation on endothelial cell secretion of tissue plasminogen activator ( tPA ) and plasminogen activator inhibitor 1 ( PAI 1 ) have not been fully elucidated . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Using enzyme linked immunosorbent assays , we determined vascular cell adhesion molecule 1 ( sVCAM 1 ) , sE selectin , plasminogen activator inhibitor 1 ( PAI 1 ) , tissue type specific plasminogen activator ( tPA ) , von Willebrand factor ( vWF ) , and soluble thrombomodulin ( sTM ) to be markers of endothelial function and determined C reactive protein ( CRP ) to be a marker of inflammation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To study the role of plasminogen activator inhibitor 1 ( PAI 1 ) and tissue plasminogen activator ( tPA ) in the accumulation of extracellular matrix ( ECM ) in the kidney of KKAy mice with type 2 diabetes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The plasminogen activator inhibitor 1 ( PAI 1 ) promoter haplotype is related to PAI 1 plasma concentrations in lean individuals . ^^^ BACKGROUND : Elevated plasminogen activator inhibitor 1 ( PAI 1 ) concentrations are associated with cardiovascular diseases . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
There were also significant increases in the renal expression of plasminogen activator inhibitor 1 ( PAI 1 ) , vascular endothelial growth factor ( VEGF ) , type 4 collagen , and fibronectin , resulting in glomerulosclerosis and proteinuria . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the liver , however , expression levels of plasminogen activator inhibitor PAI 1 , chemokine CXCL 10 , dual specificity phosphatase DUSP 1 , and hydroxysteroid specific sulfotransferases Sult2a1 / 2 were decreased 6 to 85 fold in susceptible castrated male LTbetaR ( / ) mice in comparison to resistant female LTbetaR ( / ) mice at maximal parasitaemia , as evidenced by Northern blot analyses . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Both urokinase plasminogen activator ( u PA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) are associated with a poor prognosis in cancer patients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The present study analyzed the effect of increasing the atorvastatin dose to 80 mg / day on indices of inflammation ( C reactive protein or CRP ) , thrombogenesis ( prothrombin fragment [ F1+2 ] ) and fibrinolysis ( tissue type plasminogen activator antigen , t PA , and its inhibitor PAI 1 ) in high risk patients with ischemic heart disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVES : The aim of this study was to examine whether selective plasminogen activator inhibitor type 1 ( PAI 1 ) downregulation in the acutely ischemic heart increases the myocardial microvasculature and improves cardiomyocyte ( CM ) survival . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS AND RESULTS : Data were collected on body mass index ( BMI ) , plasma CRP , plasma plasminogen activator inhibitor 1 ( PAI 1 ) , serum insulin , serum lipids , blood pressure , lifestyle and medical history . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Then the cell proliferation and cytotoxicity of HKC were determined by MTF and lactate dehydrogenase ( LDH ) release assay respectively , the antigen expression of cytokeratin and alpha smooth muscle actin on HKC was detected by immunocytochemistry , the mRNA expression of transforming growth factor beta 1 ( TGF beta 1 ) , connective tissue growth factor ( CTGF ) , plasminogen activator inhibitor 1 ( PAI 1 ) , tissue inhibitor of metalloproteinase 1 ( TIMP 1 ) and type 1 Collagen ( Col 1 ) of HKC was measured by RT PCR , and their protein expression was measured by ELISA or Western blot . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
MATERIALS AND METHODS : We analyzed the impact of levothyroxine treatment on lipid parameters , fibrinogen , platelet count , D dimers , alpha 2 antiplasmin activity , plasminogen activity , tissue plasminogen activator antigen ( t PA Ag ) , plasminogen activator inhibitor type 1 antigen ( PAI 1 Ag ) and coagulation factors ( factor 8 coagulant , von Willebrand factor antigen , von Willebrand factor and factor 9 ) in 23 patients with severe hypothyroidism ( TSH level > 50 mU / 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We therefore investigated whether direct hemoperfusion ( DHP ) with a polymyxin B immobilized fiber column ( PMX ) could reduce the level of plasminogen activator inhibitor 1 ( PAI 1 ) , an index of vascular endothelial cell activation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) regulates the proteolytic activity of urokinase type plasminogen activator ( uPA ) and there is increasing evidence for a PAI 1 role in regulating cell migration / invasion by other mechanisms like vitronectin ( VN ) binding and lipoprotein receptor related protein ( LRP ) binding . ^^^ However , manipulation of the endogenous plasminogen activator system ( using blocking antibodies to PAI 1 and to uPA ) in wound induced SKOV 3 cell migration demonstrated an important role for uPA inhibition by PAI 1 that was dependent on plasminogen . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The following examinations were performed at baseline and after treatment : ( 1 ) high resolution ultrasonography to measure the diameter changes of brachial artery in response to reactive hyperemia ( endothelium dependent ) and on administration of glyceryl trinitrate ( endothelium independent ) ; ( 2 ) high resolution ultrasonography to measure combined intima media thickness ( IMT ) of common carotid arteries ( CCA ) ; ( 3 ) fasting plasma plasminogen activator inhibitor type 1 ( PAI 1 ) activity , C reactive protein ( CRP ) and malonic aldehyde ( MDA ) concentration . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The 5 gene SNPs were cholesteryl ester transfer protein ( CETP ) TaqIB ( N = 3219 ) , ATP binding cassette ( ABCA 1 ) G596A ( N = 3302 ) , lipoprotein lipase ( LPL ) HindIII ( N = 909 ) , plasminogen activator inhibitor , type 1 ( PAI 1 ) , 4G / 5G ( N = 1142 ) , and hepatic lipase ( HL ) C 541T ( N = 4704 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVES : Our objectives were to evaluate the relation between body composition measures [ body mass index ( BMI ) , total fat mass , and appendicular lean mass ( aLM ) ] and C reactive protein ( CRP ) , interleukin 6 ( IL 6 ) , and plasminogen activator inhibitor 1 ( PAI 1 ) and to explore the effect of obesity and sarcopenia on CRP , IL 6 , and PAI 1 concentrations . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Blood samples were collected before surgery for determination of prothrombin fragments F 1 and 2 , thrombin antithrombin complex , tissue type plasminogen activator ( tPA ) activity and antigen , plasminogen activator inhibitor 1 ( PAI 1 ) activity and antigen , D dimer , homocysteine , fibrinogen , in plasma , and hematocrit in blood , and the patients underwent transcranial Doppler ultrasonology for evaluation of microembolic signals ( MES ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In eighty seven patients with CRC , the levels of IL 8 , and VEGF as representative angiogenic factors and urokinase type plasminogen activator ( uPA ) , uPA receptor ( uPAR ) , plasminogen activator inhibitor 1 ( PAI 1 ) , and PAI 2 as representative invasive factors were quantitatively assayed in tumor and adjacent normal tissues . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Cardiovascular disease markers were fibrinogen , activated factor 7 c , C reactive protein ( hsC RP ) , and the fibrolytic factors , plasminogen activator inhibitor type 1 ( PAI 1 ) , and tissue plasminogen activator [ t ( PA ) ] . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To test the hypothesis that plasminogen activator inhibitor 1 ( PAI 1 ) may serve as a candidate marker for the malignancy of colorectal cancer ( CRC ) , we performed a quantitative RT PCR for PAI 1 gene and evaluated the possible relationship between PAI 1 gene expression levels and clinicopathological findings in CRC . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : Total and % HMW adiponectin , the cytokines C reactive protein , interleukin 6 and plasminogen activator inhibitor 1 ( PAI 1 ) , as well as lipid profiles were assayed in 19 offspring , each with two type 2 diabetic parents . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We measured plasma high sensitivity C reactive protein ( hsCRP ) , interleukin 6 ( IL 6 ) , leptin , tissue type plasminogen activator ( tPA ) , plasminogen activator inhibitor 1 ( PAI 1 ) and tumour necrosis factor alpha ( TNF alpha ) after each of the two treatment periods and in 13 age and sex matched lean individuals . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The aim of the present study was to evaluate plasminogen activator activity ( PAA ) , tissue type plasminogen activator ( t PA ) antigen level and plasminogen activator inhibitor 1 ( PAI 1 ) antigen in normal canine gingival tissue samples , gingivitis as well as in different stages of periodontal disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the newborn pig , NMDA ( 10 ( 8 ) , 10 ( 6 ) M ) induced pial artery dilation was reversed to vasoconstriction following FPI , but pretreatment with the plasminogen activator inhibitor PAI 1 derived hexapeptide ( EEIIMD ) ( 10 ( 7 ) M ) prevented post injury vasoconstriction ( 9 + / 1 and 16 + / 1 , vs . 6 + / 2 and 11 + / 3 , vs . 5 + / 1 and 9 + / 1 % for responses to NMDA 10 ( 8 ) , 10 ( 6 ) M prior to FPI , after FPI , and after FPI in EEIIMD pretreated animals , respectively ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
STUDY OBJECTIVES : To measure tumor necrosis factor ( TNF ) alpha , interleukin ( IL ) 1beta , and transforming growth factor ( TGF ) beta 1 in loculated and free flowing pleural effusions caused by malignancy , tuberculosis ( TB ) , and pneumonia and their relationship with plasminogen activator inhibitor type 1 ( PAI 1 ) and tissue type plasminogen activator ( tPA ) and to compare the differences between loculated and free flowing effusions . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
KLF 5 activates many genes inducible during cardiovascular remodeling , such as platelet derived growth factor ( PDGF ) A / B , Egr 1 , plasminogen activator inhibitor 1 ( PAI 1 ) , inducible nitric oxide synthase ( iNOS ) , and vascular endothelial growth factor ( VEGF ) receptors . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is the major physiologic inhibitor of tissue type plasminogen activator in plasma , and is elevated in a variety of clinical situations that are associated with increased risk of ischemic cardiovascular events . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : Fibrinolysis in blood is mainly reflected by the activities of tissue plasminogen activator ( tPA ) and of plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To investigate the association of a common 5G / 4G polymorphism of the plasminogen activator inhibitor 1 gene ( PAI 1 ) with occurrence and clinical characteristics of the polycystic ovary syndrome ( PCOS ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
More interestingly , the use of these animals has led to the discovery of unexpected and contradictory roles ( both potentially pro and antifibrotic ) for Ang 2 , for ECM degrading enzymes matrix metalloproteinase 9 ( MMP 9 ) and tissue plasminogen activators ( PAs ) , for plasminogen activator inhibitor 1 ( PAI 1 ) , and for the adhesion molecule osteopontin ( OPN ) in obstructive nephropathy . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : Receptor regulated Smads and / or mitogen activated protein kinases ( MAPKs ) are involved in transforming growth factor beta ( TGF beta ) induced expression of various genes , including plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
ADM treatment normalized transforming growth factor ( TGF ) beta 1 mRNA expression and reduced monocyte chemoattractant protein 1 ( MCP 1 ) , osteopontin , plasminogen activator inhibitor 1 ( PAI 1 ) , collagen 1 , and collagen 3 mRNA expression significantly . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have measured : anti protein C antibodies , anti protein S antibodies , anticardiolipin antibodies ( ACA ) , anti beta 2 glycoprotein antibodies ( beta 2 GPI ) , and anti prothrombin antibodies ( aPT ) , along with prothrombin time , fibrinogen , plasminogen , protein C , protein S , anti thrombin 3 , APC resistance test , D dimer , tissue type plasminogen ' s activator , plasminogen activator inhibitor 1 ( PAI 1 ) , prothrombin fragment 1+2 , factors of the intrinsic and extrinsic pathway , C reactive protein , and homocysteine . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : Plasminogen activator inhibitor 1 ( PAI 1 ) is increased in kidneys of humans and animals with diabetic nephropathy and is associated with extracellular matrix ( ECM ) accumulation . ^^^ Urokinase plasminogen activator ( uPA ) inhibited this PAI 1 action in a dose dependent manner . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Hormone concentrations were related to CVD markers , including fibrinogen , factor 7 c , plasminogen activator inhibitor 1 ( PAI 1 ) , tissue plasminogen activator , and human serum C reactive protein ( hsCRP ) . ^^^ RESULTS : Lower estradiol levels were associated with higher levels of PAI 1 and tissue plasminogen activator , but there were no significant relationships with fibrinogen , factor 7 c , or hsCRP . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Urokinase type plasminogen activator receptor ( uPAR ) and plasminogen activator inhibitor 1 ( PAI 1 ) appear to be associated with these processes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tumor associated prognostic factors of the plasminogen activator family : determination and clinical value of u PA , t PA , PAI 1 , and PAI 2 ] . ^^^ Proteolytic factors belonging t the plasminogen activator family ( plasmin , u PA , t PA , u PAR , PAI 1 , and PAI 2 ) , which usually are involved in blood clotting and degradation of blood clots , are also present in healthy and diseased tissue of the kidney , lung , liver , gastro intestinal tract , breast , prostate , ovary , and brain . ^^^ Plasminogen activators u PA and t PA , their inhibitors PAI 1 and PAI 2 , and the u PA receptor ( u PAR , CD 87 ) are often elevated in solid malignant tumour tissues compared to their normal counterparts . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : Lipoproteins ( total cholesterol [ TC ] , low density lipoprotein cholesterol , high density lipoprotein cholesterol [ HDL C ] , triglycerides [ TG ] ) , and hemostatic factors ( fibrinogen , von Willebrand factor antigen [ vWFag ] , coagulation factors VIIag [ FVIlag ] and VIIa [ FVIIa ] , plasminogen activator inhibitor 1 [ PAI 1 ] ) were each measured once . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Profibrotic proteins , such as plasminogen activator inhibitor 1 ( PAI 1 ) , transforming growth factor beta ( TGF beta ) , and tissue type inhibitor of metalloproteinases 1 ( Timp 1 ) , are thought to play major roles in the development of fibrosis via the modulation of extracellular matrix integrity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Seventeen men and 28 women , 50 75 years old , who were generally overweight to obese , were assessed for plasminogen activator inhibitor 1 ( PAI 1 ) and tissue plasminogen activator ( t PA ) activity , t PA antigen and plasma lipoprotein lipid levels , and body composition before and after 6 months of endurance exercise training while on a low fat diet . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
While angiotensin 2 ( Ang 2 ) has been shown to inhibit migration of extravillous trophoblasts via plasminogen activator inhibitor 1 ( PAI 1 ) activation , it has remained unclear whether it stimulates or inhibits malignant behavior of choriocarcinoma cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We examined the involvement of Rho / Rho kinase signaling in CRP induced plasminogen activator inhibitor 1 ( PAI 1 ) expression in bovine aortic endothelial cells ( BAECs ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We hypothesized that depressed FMD in SLE patients is associated with increased levels of plasminogen activator inhibitor 1 ( PAI 1 ) , an inhibitor of fibrinolysis and regulator of vasoactivity . ^^^ In a multivariable regression model adjusting for t PA ( tissue plasminogen activator ) / PAI 1 ratio , SLEDAI , age at visit , family history of cardiovascular disease , SLE disease duration and body mass index , every 1 ng / mL increase in PAI 1 was associated with a reduction of 0 . 07 units FMD ( P = 0 . 039 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor type 1 ( PAI 1 ) in plasma and adipose tissue in HIV associated lipodystrophy syndrome . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma interleukin 6 ( IL 6 ) , C reactive protein ( CRP ) , plasminogen activator inhibitor type 1 ( PAI 1 ) , and tumor necrosis factor alpha ( TNF alpha ) levels were measured in all participants . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The induction of 2 known targets of Ets 1 , cyclin dependent kinase inhibitor p21CIP and plasminogen activator inhibitor 1 ( PAI 1 ) , by Ang 2 is markedly blunted in the aorta of Ets 1 / mice compared with wild type controls . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
MATERIALS AND METHODS : Prior to administration of thrombolytic therapy , venous blood was collected from 110 patients presenting with acute ST segment elevation myocardial infarction and plasma assayed for tissue plasminogen activator ( t PA ) antigen and activity , plasminogen activator inhibitor type 1 antigen ( PAI 1 ) , TAFI antigen and activity , C reactive protein ( CRP ) and sCD40L concentrations . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Upregulation of plasminogen activator inhibitor type 1 ( PAI 1 ) expression is a critical mechanism through which transforming growth factor beta 1 ( TGF beta 1 ) accelerates intimal growth . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Blood samples obtained from left ventricle ( LV ) and pulmonary artery ( PA ) of each patient were analyzed for levels of plasminogen activator inhibitor 1 ( PAI 1 ) , platelet derived growth factor ( PDGF ) , vascular endothelial growth factor ( VEGF ) , D dimer , von Willebrand factor ( vWF ) , protein C , antithrombin 3 , fibrinogen , and plasminogen . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Increased plasminogen activator inhibitor 1 ( PAI 1 ) is linked to obesity and insulin resistance . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
When infused in animals after vascular injury , Serp 1 elicits exceptional anti inflammatory activity , whereas the mammalian serpin , plasminogen activator inhibitor 1 ( PAI 1 ) , which also targets thrombotic and thrombolytic proteases can induce a pro thrombotic response . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
As plasminogen activator inhibitor 1 ( PAI 1 ) accentuates cell migration , with JNK activation recently shown to up regulate PAI 1 expression , this suggested that systemic JNK inhibition may down regulate LPS induced pulmonary neutrophil recruitment through a decrease in PAI 1 expression . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Transforming growth factor beta 1 ( TGF beta 1 ) , connective tissue growth factor ( CTGF ) , plasminogen activator inhibitor 1 ( PAI 1 ) , tissue inhibitor of metalloproteinase 1 ( TIMP 1 ) and type 1 collagen ( Col 1 ) in kidney tissue were determined by RT PCR and immunohistochemical method , respectively . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We used polymerase chain reaction techniques to characterize thrombophilic gene mutations ( G1691A 5 Leiden [ FV ] , G20210A prothrombin , C677T / A1298C MTHFR ) and hypofibrinolytic gene mutations ( plasminogen activator inhibitor [ PAI 1 ] activity 4G4G ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Recently , we found that alpha ( 1 ) acid glycoprotein ( AGP ) , one of the major acute phase proteins , forms a function stabilizing complex with plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
While the pathogenesis of VOD is uncertain , plasminogen activator inhibitor 1 ( PAI 1 ) has emerged as a diagnostic marker and predictor of VOD in humans . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : The rat model of portal branch ligation ( PBL ) was compared with partial hepatectomy ( PH ) and sham operation ( SO ) and evaluated for the expression of heat shock protein 70 ( hsp 70 ) , heme oxygenase 1 ( hmox 1 ) , early growth response gene 1 ( Egr 1 ) and urokinase type plasminogen activator ( uPA ) , its inhibitor ( PAI 1 ) and receptor ( uPAR ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Pericytes influence endothelial cell growth characteristics : role of plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : Markers of fibrinolysis , thrombin activatable fibrinolysis inhibitor ( TAFI ) , tissue type plasminogen activator ( tPA ) , and plasminogen activator inhibitor 1 ( PAI 1 ) levels were studied for the evaluation of short term effects of raloxifene administration in postmenopausal women . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In women with polycystic ovary syndrome , metformin administration , not laparoscopic ovarian drilling , reduces plasminogen activator inhibitor 1 ( PAI 1 ) activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Overexpression of KLF 4 in J774a macrophages induced the macrophage activation marker inducible nitric oxide synthase and inhibited the TGF beta 1 and Smad 3 target gene plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : Using a linkage disequilibrium ( LD ) based approach , we sought to comprehensively define common genetic variation at the plasminogen activator inhibitor 1 ( PAI 1 ) locus and relate common single nucleotide polymorphisms ( SNPs ) and haplotypes to plasma PAI 1 levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
TG , insulin , CRP , plasminogen activator inhibitor 1 ( PAI 1 ) and soluble intracellular adhesion molecule 1 ( sICAM 1 ) fell after weight loss , but FMD did not change . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVES : To evaluate urokinase plasminogen activator ( u PA ) , urokinase plasminogen activator soluble receptor ( su PAR ) , plasminogen activator inhibitor 1 ( PAI 1 ) and tissue plasminogen activator ( t PA ) plasma levels in SSc patients ( pts ) versus healthy controls and their modulation by intravenous alphacyclodestrine ( Alprostadil ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
ROS thus generated activate signal transduction cascade ( PKC , mitogen activated protein kinases , and janus kinase / signal transducers and activators of transcription ) and transcription factors ( nuclear factor kappaB , activated protein 1 , and specificity protein 1 ) , up regulate transforming growth factor beta 1 ( TGF beta 1 ) , angiotensin 2 ( Ang 2 ) , monocyte chemoattractant protein 1 ( MCP 1 ) , and plasminogen activator inhibitor 1 ( PAI 1 ) gene and protein expression , and promote formation of advanced glycation end products ( AGE ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) plays a central role in the modulation of intravascular thrombosis and thrombolysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
RESULTS : Plasma hs CRP , fibrinogen , 5 WF and plasminogen activator inhibitor 1 ( PAI 1 ) activity levels were markedly higher ( P < 0 . 01 or less ) in subjects with non alcoholic HS ( n = 35 ) than in those without HS ( n = 65 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This is easily explained by the fact that the liver , once fatty , overproduces most of the known cardiovascular risk factors such as very low density lipoprotein ( VLDL ) , glucose , C reactive protein ( CRP ) , plasminogen activator inhibitor 1 ( PAI 1 ) , fibrinogen and coagulation factors . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND AND PURPOSE : The tissue type plasminogen activator ( tPA ) 7351C > T and the plasminogen activator inhibitor type 1 ( PAI 1 ) 675 4G > 5G polymorphisms influence transcriptional activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OE DEP and OE UFP exposure reduced plasminogen activator inhibitor 1 ( PAI 1 ) production by the cells but did not affect the production of thrombomodulin , tissue type plasminogen activator , or urokinase type plasminogen activator . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Acetaminophen treatment also significantly increased plasminogen activator inhibitor 1 ( PAI 1 ) activity and plasma fibrinogen level , and decreased antithrombin 3 ( AT 3 ) and protein C activities ( P < 0 . 05 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Levels of prothrombin fragment 1+2 ( F1+2 ) , factor 7 , plasminogen activator inhibitor 1 ( PAI 1 ) and tissue factor pathway inhibitor ( TFPI ) antigens , but not tissue plasminogen activator ( tPA ) antigen , in the pre simvastatin plasmas of the diabetic patients were significantly higher than the levels found in plasmas of healthy subjects . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : The role of vitronectin ( VN ) in thrombosis is not fully understood , primarily because this adhesive glycoprotein not only stabilizes plasminogen activator inhibitor 1 ( PAI 1 ) and thus protects fibrin from premature lysis , but also because it binds to platelet integrins and may influence platelet aggregation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Anthropometric variables , blood pressure , sex steroid hormones , HbA1c , serum and lipoprotein lipids , plasminogen activator inhibitor 1 ( PAI 1 ) and insulin like growth factor 1 ( IGF 1 ) were measured . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
AIMS / HYPOTHESIS : The aim of this study was to investigate the effects of lifestyle intervention on the levels of plasminogen activator inhibitor ( PAI 1 ) and fibrinogen in subjects participating in the Finnish Diabetes Prevention Study ( DPS ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
MAIN OUTCOME MEASURE ( S ) : After 24 hours ' incubation , tissue plasminogen activator ( tPA ) , urokinase plasminogen activator ( uPA ) , and plasminogen activator inhibitor 1 ( PAI 1 ) levels were determined in medium and cell lysates by using ELISA techniques . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Recent studies have shown that women who have PCOS have higher circulating levels of inflammatory mediators such as C reactive protein , tumor necrosis factor , tissue plasminogen activator , and plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
On day 6 , glomeruli were harvested and markers of fibrosis [ plasminogen activator inhibitor 1 ( PAI 1 ) , transforming growth factor beta ( TGF beta ) , fibronectin , periodic acid Schiff ( PAS ) staining ] were analyzed . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is implicated not only in thrombosis , but also in fibrosis , by inhibiting matrix degradation , and is expressed in renal parenchymal cells as well as in macrophages . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Genes associated with extracellular matrix remodeling , including members of the matrix metalloproteinases ( MMPs ) and tissue inhibitors of the MMP ( TIMP ) family , urokinase plasminogen activator and its inhibitor plasminogen activator inhibitor 1 ( PAI 1 ) , and CTGF and CYR 61 ( members of the Cysteine rich 61 , Connective Tissue Growth Factor and Nephroblastoma overexpressed ( CCN ) gene family of growth regulators ) , were among the ones significantly altered in the OXPHOS deficient cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is an acute phase protein known to correlate with hepatic fibrosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The present study was designed to evaluate angiotensinogen ( AGT ) M235T and plasminogen activator inhibitor 1 ( PAI 1 ) ( 4G / 5G ) polymorphisims in relation to the occurrence of atherosclerotic renal artery stenosis ( ARAS ) and recurrent stenosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To evaluate the effect of high glucose on the expression of fibronectin ( FN ) and plasminogen activator inhibitor 1 ( PAI 1 ) in human peritoneal mesothelial cells ( HPMC ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The 4G allele frequency of the plasminogen activator inhibitor 1 ( PAI 1 ) gene , associated with hypofibrinolysis , was 56 of 88 ( 64 % ) in cases vs 79 of 166 ( 48 % ) in controls , 10 ( 2 ) = 5 . 95 , p = . 015 . ^^^ The PAI 1 gene product , plasminogen activator inhibitor activity ( PAI Fx ) , was higher in cases than controls ( age race sex adjusted mean 12 . 2 U / mL vs 6 . 3 , p = . 013 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Polymerase chain reaction assays were done for four thrombophilic and one hypofibrinolytic gene mutations : G1691A factor 5 Leiden , G20210A prothrombin , C677T MTHFR , platelet glycoprotein IIb / IIIa ( PL A1 / A2 ) , and 4G / 5G polymorphism of the plasminogen activator inhibitor ( PAI 1 ) gene promoter . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In preterm preeclampsia , significantly reduced antithrombin 3 ( ATIII ) and PAI 2 levels with further elevated tissue type PA ( t PA ) antigen and plasminogen activator inhibitor 1 ( PAI 1 ) antigen were seen compared to normal pregnancy . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
More importantly , they both significantly inhibited the expression of plasminogen activator inhibitor type 1 ( PAI 1 ) and type 1 collagenalpha 1 ( Col Ialpha 1 ) genes in rat hepatic stellate cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The most upregulated gene identified encodes plasminogen activator inhibitor 1 ( PAI 1 , Serpine 1 ) , a protease inhibitor that blocks urokinase plasminogen activator ( uPA ) and tissue type plasminogen activator ( tPA ) activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
DN c Jun , which was transferred to the heart 2 days before AngII infusion , prevented cardiac hypertrophy ( P < 0 . 01 ) , decreased p70S6 kinase phosphorylation ( P < 0 . 05 ) , and suppressed cardiac gene expression of brain natriuretic peptide , collagen 1 , 3 , and 4 , monocyte chemoattractant protein 1 ( MCP 1 ) and plasminogen activator inhibitor 1 ( PAI 1 ) ( P < 0 . 01 ) . ( 2 ) In genetically hypertensive rats with cardiac hypertrophy , cardiac gene transfer of Ad . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Longitudinal changes in multiple plasma analytes , including insulin , the adipokines leptin , resistin , and adiponectin , and plasminogen activator inhibitor 1 ( PAI 1 ) allowed profiling of the differential Rosi responses in steatosis exacerbated F 1 and RCS 8 males vs . the resistant RCS 1 and RCS 2 or moderately sensitive RCS 10 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The following parameters were determined : prothrombin time ( PT ) , activated partial thromboplastin time ( aPTT ) , factors 7 , 10 , and 12 activity , fibrinogen levels , thrombin antithrombin complex levels , protein C and S antigen , antithrombin activity , plasminogen activator inhibitor type 1 ( PAI 1 ) antigen , tissue type plasminogen activator ( t PA ) antigen , plasminogen activity and fibrin degradation products ( FbDP ) antigen . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Blood was taken prior to PCI for baseline measurement of : ( 1 ) vasoconstrictive factors : endothelin ( ET ) and serotonin ( 5 HT ) ; ( 2 ) thrombotic factors : tissue factor ( TF ) , plasminogen activator inhibitor ( PAI 1 ) , thrombin / antithrombin 3 complex ( TAT ) , and prothrombin fragment F1+2 ( F1+2 ) ; and ( 3 ) inflammatory factors : soluble CD 40 ligand ( sCD40L ) and soluble E selectin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In a number of cancer types high tumor tissue levels of plasminogen activator inhibitor type 1 ( PAI 1 ) protein are strongly associated with shorter cancer patient survival . ^^^ This association has been intriguing since PAI 1 is known to inhibit urokinase plasminogen activator ( uPA ) that converts plasminogen to plasmin , which is actively involved in tumor progression and invasion . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Our previous studies showed that thymosin beta 4 ( Tbeta 4 ) induced the synthesis of plasminogen activator inhibitor 1 ( PAI 1 ) in cultured human umbilical vein endothelial cells ( HUVECs ) via the AP 1 dependent mechanism and its enhanced secretion . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) gene transfection inhibits the liver metastasis of pancreatic cancer by preventing angiogenesis . ^^^ Plasminogen activator inhibitor 1 ( PAI 1 ) is a unique type of serine protease inhibitor and one of the key regulators of tumor invasion and metastasis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have studied tissue type plasminogen activator ( t PA ) and its inhibitor ( PAI 1 ) , and d dimer levels in BS patients with and without thrombosis both in the acute and chronic phases along with suitable diseased and healthy controls . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Twenty cases were studied for immunoreactivity for muscle specific actin ( MSA ) , SMA , desmin , h caldesmon , calponin , TGF beta 1 , and plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor type 1 ( PAI 1 ) is induced by many proinflammatory and pro oxidant factors . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The expression levels of transforming growth factor beta 1 ( TGF beta 1 ) , connective tissue growth factor ( CTGF ) , fibronectin ( FN ) and plasminogen activator inhibitor 1 ( PAI 1 ) were detected by real time quantitative reverse transcriptase polymerase chain reaction ( RT PCR ) at the end of the experiment . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To test the hypothesis that alveolar plasminogen activator inhibitor 1 ( PAI 1 ) can identify patients with witnessed aspiration at risk for progression to acute respiratory distress syndrome ( ARDS ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
On univariable analysis , fibrinogen , low activated protein C ratio , D dimer , tissue plasminogen activator ( tPA ) , and plasminogen activator inhibitor 1 ( PAI 1 ) were associated significantly with risk of CVD . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The increased levels of urokinase type plasminogen activator ( uPA ) , uPA receptor ( uPAR ) and type 1 PA inhibitor ( PAI 1 ) are reported in human renal cell carcinoma ( RCC ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
PURPOSE : To determine the association of central obesity with the components of the metabolic syndrome ( i . e . , hyperinsulinemia , hypertension , hypertriglyceridemia , low levels of high density lipoprotein cholesterol [ HDL C ] ) and plasma levels of plasminogen activator inhibitor 1 ( PAI 1 ) in young adults . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
RESULTS : High glucose stimulated a striking increase in BRPC gremlin mRNA levels in parallel with increases in mRNA for the growth factors vascular endothelial growth factor ( VEGF ) , transforming growth factor beta ( TGFbeta ) , and connective tissue growth factor ( CTGF ) and changes in other genes including fibronectin and plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor type 1 ( PAI 1 ) and platelet glycoprotein IIIa ( PGIIIa ) polymorphisms in young Asian Indians with acute myocardial infarction . ^^^ BACKGROUND : The relationship between polymorphisms in the genes for plasminogen activator inhibitor type 1 ( PAI 1 ) and platelet glycoprotein IIIa ( PGIIIa ) , clinical and environmental features , and the risk of premature coronary heart disease ( CHD ) in Asian Indian subjects living in South Africa , has been investigated . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To verify the applicability of the cell invasion model , multilayer cell constructs of oral squamous cell carcinoma and oral mucosal fibroblasts were exposed to extrinsic urokinase type plasminogen activator ( uPA ) or plasminogen activator inhibitor ( PAI 1 ) , which are known effectors of cell migration . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A study of the serum levels of the plasminogen activator inhibitor 1 ( PAI 1 ) , the major inhibitor of tPA , found that women with MDD had a higher PAI 1 concentration than normal controls . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tumour necrosis factor ( TNF ) alphaalpha , plasminogen activator inhibitor 1 ( PAI 1 ) and heparin binding epidermal growth factor like growth factor ( HBEGF ) are among these adipocytokines , and they contribute to the development of vascular diseases . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This turnover is regulated by matrix metalloproteinases ( MMPs ) , tissue inhibitor of matrix metalloproteinases ( TIMPs ) , and the plasminogen activation system , including tissue type plasminogen activator ( tPA ) , urokinase type plasminogen activator ( uPA ) , and plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This defect results at least in part from increased expression of plasminogen activator inhibitor type 1 ( PAI 1 ) , a serine protease inhibitor ( serpin ) that controls extracellular proteolysis and cell matrix adhesion . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
TGF beta 1 up regulates plasminogen activator inhibitor type 1 ( PAI 1 ) , which lowers matrix degradation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To determine the effect of indomethacin on high concentration glucose and lipopolysaccharide ( LPS ) induced fibronectin ( FN ) and plasminogen activator inhibitor 1 ( PAI 1 ) secretion in cultured human peritoneal mesothelial cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Furthermore , PH / LPS caused a > 200x increase in hepatic plasminogen activator inhibitor 1 ( PAI 1 ) mRNA expression and plasma PAI 1 protein . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Transcriptional regulation of the plasminogen activator inhibitor type 1 ( PAI 1 ) gene is an important issue since PAI 1 plays a crucial role in various pathological conditions . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
IFN gamma also abolished TGF beta ( 1 ) induced fibronectin and plasminogen activator inhibitor 1 ( PAI 1 ) expression . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : Hormone replacement therapy ( HRT ) has generally been documented to reduce plasminogen activator inhibitor 1 ( PAI 1 ) and fibrinogen levels in plasma of postmenopausal women . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We conducted a large trial in order to investigate the value of plasminogen activator inhibitor 1 ( PAI 1 ) plasma antigen levels in VOD patients as PAI 1 has been described as a possible diagnostic marker of VOD . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
RESULTS : Naringenin reduced not only the accumulation of ECM , including collagen Ialpha 1 ( Col Ialpha 1 ) , fibronectin ( FN ) , and plasminogen activator inhibitor 1 ( PAI 1 ) , but also the production of Smad 3 induced by TGF beta 1 in both mRNA and protein levels in a dose dependent manner . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The paper is dedicated to the study of structure and physiological functions of tissue type plasminogen activator and its inhibitor PAI 1 , changes of these parametres in normal and pathology conditions . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Vascular Endothelial Growth Factor ( VEGF ) , tissue type Plasminogen Activator ( tPA ) , Plasminogen Activator Inhibitor 1 ( PAI 1 ) and lipoprotein ( lp ) ( a ) influence the pro coagulant status . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In 438 patients with AAA , and in 438 healthy subjects , selected to be comparable for age and gender with patients and without instrumental evidence of AAA , a pattern of thrombophilic parameters [ homocysteine ( Hcy ) , lipoprotein ( a ) [ Lp ( a ) ] , plasminogen activator inhibitor 1 ( PAI 1 ) , anticardiolipin antibodies ( ACA ) , MTHFR C677T polymorphism , prothrombin gene G20210A variant and FactorV Leiden mutation ] has been evaluated . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In glomerular mesangial cells , HG stimulated plasminogen activator inhibitor 1 ( PAI 1 ) gene expression requires the HBP and the transcription factor , Sp 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We summarize the data on the role of leptin , adiponectin , the growth hormone axis , glucocorticoids , sterol response element binding protein 1c ( SREBP 1c ) , the tumor necrosis factor alpha axis ( TNF alpha ) , interleukin 6 ( IL 6 ) , interleukin 18 ( IL 18 ) , interferon alpha ( IFN alpha ) , tissue plasminogen activator ( tPA ) , and plasminogen activator inhibitor ( PAI 1 ) in the pathophysiology of LD . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Human or rat mesangial cells ( MCs ) were treated with human recombinant renin ( HrRenin ) or rat recombinant renin ( RrRenin ) and the effects on TGF beta 1 , plasminogen activator inhibitor type 1 ( PAI 1 ) , fibronectin ( FN ) and collagen 1 mRNA and protein were investigated . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
These bioactive molecules include proteins that modify insulin sensitivity ( acylation stimulating protein ( ASP ) , TNF alpha IL 6 , resistin , leptin and adiponectin ) , and proteins that have known effects on vascularity ( angiotensinogen and the plasminogen inhibitor protein PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We measured glycosylated hemoglobin ( HbA1c ) , plasma high sensitivity C reactive protein ( hs CRP ) , plasminogen activator inhibitor 1 ( PAI 1 ) , 8 epi prostaglandin F 2 alpha ( PGF2alpha ) , serum lipoprotein ( a ) [ Lp ( a ) ] , and lipoprotein profile at baseline and after 20 weeks of treatment . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The components of the plasminogen activator ( PA ) system ( urokinase type PA , uPA ; PA inhibitors , PAI 1 / 2 ; uPA receptor , uPAR ) have been implicated in the local degradation of the extracellular matrix ( ECM ) and PCa progression . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have studied the expression of plasminogen activator inhibitor 1 ( PAI 1 ) and urokinase receptor ( uPAR ) together with the gamma 2 chain of laminin 5 ( lam gamma 2 ) by immunohistochemistry in 20 cases with incipient oral squamous cell carcinoma ( SCC ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Serum CRP , plasma t PA and PAI 1 ( plasminogen activator inhibitor type 1 ) concentrations were determined in 95 patients with stable coronary heart disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Survivin expression in breast cancer predicts clinical outcome and is associated with HER 2 , VEGF , urokinase plasminogen activator and PAI 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We wanted to study plasminogen activators , urokinase ( uPA ) and tissue type ( tPA ) and their inhibitor PAI 1 , which have not earlier been studied comprehensively in cutaneous NF 1 related tumors . ^^^ We analyzed the distribution of uPA , tPA and PAI 1 antigen level by immunohistochemistry and mRNA level by in situ hybridization , to identify which cells are primarily involved in proteolytic activity and plasminogen activation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : Prospective studies of the epidemiology and clinical significance of low plasminogen activator inhibitor type 1 ( PAI 1 ) activity are lacking . ^^^ METHODS : In 586 consecutive patients , referred because of bleeding symptoms , we added analyses of PAI 1 activity and tissue plasminogen activator complex with PAI 1 ( t PA PAI 1 ) to the routine investigation , consisting of platelet count , bleeding time , prothrombin time , activated partial thromboplastin time , fibrinogen , factor 8 , von Willebrand factor activity , and antigen . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Adipose tissue is an active endocrine organ secreting different adipokines such as plasminogen activator inhibitor 1 ( PAI 1 ) and adiponectin , among many others . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) is the major physiological inhibitor of fibrinolysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : Plasminogen activator inhibitor 1 ( PAI 1 ) plays an important role in the regulation of fibrinolysis and extracellular matrix turnover . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
At the end of each treatment period plasma cyclic guanosine monophosphate ( cGMP ) , monocyte chemoattractant pertide 1 ( MCP 1 ) , nitric oxide metabolites ( NO ( 10 ) ) , plasminogen activator inhibitor 1 ( PAI 1 ) and von Willebrand factor ( vWf ) ; and serum C reactive protein ( CRP ) and platelet derived growth factor ( PDGF ) ; were measured blinded to treatment . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
TGFbeta is a major regulator of extracellular matrix deposition and a potent inducer of type 1 plasminogen activator inhibitor ( PAI 1 ) gene expression . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To explore the effect of plasminogen activator inhibitor 1 ( PAI 1 ) gene variations on the risk of coronary heart disease ( CHD ) in Chinese Han population . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
These include hyperhomocysteinemia , elevated C reactive protein , antiphospholipid antibodies , elevated fibrinogen , Factor 7 , plasminogen activator inhibitor 1 ( PAI 1 ) , hereditary thrombophilias , and platelet hyper reactivity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) regulates not only fibrinolysis but extracellular matrix remodeling , and angiotensin 2 is known to play an important role in controlling the expression of PAI 1 in astrocytes . ^^^ We conclude that IL 1beta increases angiotensin 2 induced PAI 1 secretion by astrocytes through the induction of AT 1 , and the enhanced secretion of PAI 1 may modulate functions of plasminogen activators in the nervous system . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Here we show that 13 deoxytedanolide strongly induces plasminogen activator inhibitor 1 ( PAI 1 ) promoter derived gene expression . 13 Deoxytedanolide , unlike TGF beta , did not cause apparent nuclear translocation of Smad2 / 3 , but it relocalized the temperature sensitive mutant of mouse p 53 ( p53Val153 ) from the cytoplasm to the nucleus at a nonpermissive temperature , suggesting that 13 deoxytedanolide inhibits protein synthesis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Samples were analyzed for the plasma plasminogen , plasminogen activator inhibitor ( PAI 1 ) , fibrinogen , and coagulation factors ( 2 , 5 , 7 , 8 , and 10 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : The prognostic relevance of urokinase type plasminogen activator ( u PA ) , u PA receptor ( u PAR ) , and plasminogen activator inhibitor 1 ( PAI 1 ) in gastric carcinoma was demonstrated in an independent patient series . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A multiplexed fluorescence immunoassay using a novel planar waveguide technology based microarray system , ZeptoMARK ( Zeptosens ) , was developed to detect simultaneously urokinase type plasminogen activator ( uPA ) , plasminogen activator inhibitor 1 ( PAI 1 ) , and vascular endothelial growth factor ( VEGF ) in extracts of breast cancer tissues . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We tested the hypothesis that elevated levels of hemostatic markers of endothelial dysfunction , plasminogen activator inhibitor 1 ( PAI 1 ) antigen , and von Willebrand factor ( vWF ) antigen predicted incident diabetes independent of other diabetes risk factors . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The effect of anthracycline based adjuvant chemotherapy regimens on fibrinolytic system markers of plasminogen activator inhibitor 1 ( PAI 1 ) and thrombin activitable fibrinolysis inhibitor ( TAFI ) was investigated in patients with operable breast cancer . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma global fibrinolytic capacity ( GFC ) , tissue plasminogen activator ( t PA ) , and plasminogen activator inhibitor 1 ( PAI 1 ) levels were measured . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
C reactive protein , CRP ) , increased oxidant stress ( e . g . oxidized low density lipoprotein , LDL ) , thrombophilia ( e . g . plasminogen activator inhibitor 1 , PAI 1 ) and endothelial dysfunction ( e . g . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The aim of this study was to investigate the effect of CD40 / CD40L interaction on PTEC expression of plasminogen activator inhibitor 1 ( PAI 1 ) , a powerful profibrotic mediator , and monocyte chemoattractant protein 1 ( MCP 1 ) , a proinflammatory cytokine , and to investigate the signaling pathways that lead to these effects . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Transforming growth factor beta 1 ( TGF beta 1 ) transcriptionally regulates the expression of genes that encode specific proteins ( e . g . , plasminogen activator inhibitor 1 ; PAI 1 ) important in stromal remodeling and cellular invasion . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We reported that notoginsenoside R 1 significantly decreased tumor necrosis factor alpha ( TNF alpha ) induced plasminogen activator inhibitor 1 ( PAI 1 ) mRNA , protein level and secretion in human aortic smooth muscle cells ( HASMCs ) in a dose dependent manner . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The activities of tissue and urokinase plasminogen activators ( tPA and uPA , respectively ) , the relative inhibition of tPA , and the amounts of plasminogen activator inhibitors 1 and 2 ( PAI 1 and PAI 2 , respectively ) in cell free saliva were studied . ^^^ Tissue plasminogen activator , PAI 1 , and PAI 2 were evident in salivary gland tissue , whereas the expression of uPA was low . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : Plasminogen activator inhibitor type 1 ( PAI 1 ) is the main inhibitor of the fibrinolytic system and contributes to an increased risk of atherothrombosis in insulin resistant obese patients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS AND RESULTS : Mice with single or combined deficiencies of apolipoprotein E ( ApoE ) and plasminogen activator inhibitor 1 ( PAI 1 ) were used . ^^^ Ex vivo incubation with plasminogen of isolated aortic tunica media from PAI 1 deficient mice induced plasminogen activation and VSMC apoptosis , which was inhibited by alpha 2 antiplasmin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) , a member of the serpin super family , forms a covalent complex with its target proteinases , such as tissue and urokinase plasminogen activators . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
As gene variants predisposing to thrombophilia and influencing the increased risk of vein thrombosis might influence response to local thrombolysis , the aim of the work was to characterize the pharmacogenetic conditions for local streptokinase treatment in patients with a deep vein thrombosis ( DVT ) of lower extremities based on the following polymorphism analyses : G1691A polymorphism of factor 5 ( FV ) , G20210A polymorphism of prothrombin ( PT ) , A4250G ( Thr312Ala ) polymorphism of fibrinogen alpha ( FGA ) , G ( 455 ) A polymorphism of fibrinogen beta ( FGB ) , 4G / 5G polymorphism of plasminogen activator inhibitor type 1 ( PAI 1 ) and insertion / deletion ( I / D ) polymorphism of tissue plasminogen activator ( t PA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The present study has shown that cell preparation procedure , i . e . , cell collection by centrifugation and the subsequent adjustment and culture of cell density at the desired concentrations , transiently induced gene expression of plasminogen activator inhibitor 1 ( PAI 1 ) and the AP 1 components ( c fos , c jun , and junB ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Hemostatic factors associated with the development of cardiovascular disease ( CVD ) include fibrinogen , von Willebrand factor , tissue plasminogen activator ( tPA ) antigen , plasminogen activator inhibitor 1 ( PAI 1 ) , and factor 7 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We assessed whether hypofibrinolytic plasminogen activator inhibitor 1 ( PAI 1 activity ) showed an independent association with first trimester miscarriage in the 430 women with polycystic ovary syndrome ( PCOS ) who had previous pregnancies ( from a cohort of 967 women with PCOS ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Prothrombin time ( PT ) , activated partial thromboplastin time ( aPTT ) , fibrinogen , factors 5 , 7 , 8 , 9 and 10 activities , vWF , antithrombin 3 ( AT 3 ) , protein C , protein S , tissue plasminogen activator ( t PA ) and tissue plasminogen activator inhibitor 1 ( PAI 1 ) , as well as common lipid variables , were measured . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue type plasminogen activator ( tPA ) regulates vascular contractility through the low density lipoprotein related receptor ( LRP ) , and this effect is inhibited by plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Elevated plasma concentrations of plasminogen activator inhibitor 1 ( PAI 1 ) have been shown to be associated with increased CVD , and there is evidence of a significant relationship between PAI 1 and fibrinogen levels and both insulin resistance and hyperinsulinemia . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The determination of the protein content of urokinase type plasminogen activator ( uPA ) and its inhibitor , PAI 1 , in breast cancer tissue extracts is used clinically to identify patients at risk to experience disease recurrence ( metastasis ) or early death . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
For cellular invasive processes during a variety of physio and pathophysiological events , including cancer , a fine tuned balance between the formation and loosening of cell adhesive contacts has to occur , implicating the action of pericellular proteases ; among those , the serine protease , urokinase type plasminogen activator ( uPA ) , its inhibitor PAI 1 , and its cellular receptor uPA R ( CD 87 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Here we demonstrate that TGF beta 1 induces transcriptional activation of plasminogen activator inhibitor 1 ( PAI 1 ) and growth inhibition more potently in CHO cell mutants deficient in heparan sulfate ( CHO 677 cells ) than in wild type CHO K 1 cells . 125I TGF beta 1 affinity labeling analysis of cell surface TGF beta receptors reveals that CHO K 1 and CHO 677 cells exhibit low ( < 1 ) and high ( > 1 ) ratios of 125I TGF beta 1 binding to TbetaR 2 and TbetaR 1 , respectively . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The diabetic patient exhibits a pathological coagulation state , with an increased synthesis of coagulation factors and plasminogen activator inhibitor 1 ( PAI 1 ) as well as an enhanced aggregation of platelets . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The influence of I / D polymorphism of the angiotensin 1 converting enzyme ( ACE ) gene and 4G / 5G polymorphism of plasminogen activator inhibitor ( PAI 1 ) gene promoter on the haemostatic system in patients with essential hypertension and dyslipidemia ] . ^^^ Tissue plasminogen activator ( t PA ) and its inhibitor ( PAI 1 ) , von Willebrand factor ( vWF ) , and soluble thrombomodulin ( sTM ) are haemostatic markers of endothelial injury related to hypertension . ^^^ CONCLUSION : The results led to the following conclusions : ( 1 ) Untreated essential hypertension is associated with the prothrombotic state reflected by increased levels of fibrinogen and tissue plasminogen activator and its inhibitor ; ( 2 ) Deletion alleles ( D or 4G ) potentiate the prothrombotic state manifested by fibrinolytic disturbances in hypertensive patients as compared with normotensive subjects ; ( 3 ) Lipid disorders enhance the prothrombotic effect of deletion alleles ( D or 4G ) in untreated essential hypertension ; ( 4 ) There is no interaction between ACE I / D and PAI 1 4G / 5G polymorphisms in the regulation of levels of haemostatic factors . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Hemostatic variables including factor 7 activity ( FVIIa ) , tissue factor pathway inhibitor factor Xa complex ( TFPI / Xa ) , and plasminogen activator inhibitor 1 ( PAI 1 ) antigen / activity as well as leukocyte tumor necrosis factor alpha ( TNF alpha ) gene expression were determined among four subjects . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In blood samples , the following markers of coagulation / fibrinolysis were measured before treatment : fibrinogen , prothrombin fragments 1+2 , Factor 13 , Factor 7 , alpha 2 antiplasmin , plasminogen activator inhibitor 1 ( PAI 1 ) , and thrombin activatable fibrinolysis inhibitor . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Primary outcome measures were plasminogen activator inhibitor 1 ( PAI 1 ) , tissue plasminogen activator ( tPA ) and D dimer levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Partial hepatectomy causes hemodynamic changes that increase portal blood flow in the remaining lobe , where the expression of immediate early genes , including plasminogen activator inhibitor 1 ( PAI 1 ) , is induced . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : Plasminogen activator inhibitor 1 ( PAI 1 ) expression are increased in adipose tissues / adipocytes of obese mice , which is associated with a hypofibrinolytic state that contributes to thrombosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Bone matrix turnover is regulated by matrix metalloproteinases ( MMPs ) , tissue inhibitors of matrix metalloproteinases ( TIMPs ) , and the plasminogen activation system , including tissue type plasminogen activator ( tPA ) , urokinase type plasminogen activator ( uPA ) , and plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The high affinity binding site in human vitronectin ( VN ) for plasminogen activator inhibitor 1 ( PAI 1 ) has been localized to the NH ( 2 ) terminal cysteine rich somatomedin B ( SMB ) domain ( residues 1 44 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Impaired fibrinolysis and increased concentrations in blood of plasminogen activator inhibitor 1 ( PAI 1 ) are related to insulin resistance and abdominal obesity and may contribute to the increased risk for cardiovascular disease in this group . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This study tests the hypothesis that plasminogen activator inhibitor 1 ( PAI 1 ) contributes to aldosterone induced renal and cardiac injury . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Before infection , diabetic mice had significantly higher plasminogen activator inhibitor 1 ( PAI 1 ) activity , lower antithrombin 3 ( AT 3 ) and protein C activities ( P < 0 . 05 ) , and MRSA infection significantly increased PAI 1 activity further and reduced the activity of AT 3 and protein C ( P < 0 . 05 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
They include leptin , adiponectin , resistin , acylation stimulating protein ( ASP ) , plasminogen activator inhibitor 1 ( PAI 1 ) , tumor necrosis factor alpha ( TNFalpha ) , interleukin 6 , and angiotensinogen . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Elevated plasma levels of plasminogen activator inhibitor type 1 ( PAI 1 ) , a significant risk factor of ischemic heart disease , are associated with insulin resistance in which insulin and transforming growth factor ( TGF ) beta play a pivotal role in regulating PAI 1 production . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Hypoxia in rodents and humans is associated with a reduction of body fat on the one hand , and with enhanced expression of plasminogen activator inhibitor 1 ( PAI 1 ) , the main inhibitor of the fibrinolytic system , on the other hand . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We studied the effect of different glucose lowering therapies on serum levels of plasminogen activator inhibitor 1 ( PAI 1 ) , high sensitivity C reactive protein ( hs CRP ) , TNF alpha , leptin , adiponectin and ghrelin in patients with type 2 diabetes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Additionally , NAC dose dependently decreased expression of three major indicators of impaired fibrotic matrix turnover , namely alpha smooth muscle actin ( alpha SMA ) , alpha 1 type 1 procollagen ( Col1A1 ) , and plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Activities and concentrations of tissue plasminogen activator ( t PA ) , plasminogen activator inhibitor type 1 ( PAI 1 ) and t PA / PAI complex were determined in all specimen by ELISA kits . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the present study , we demonstrate that the inhibition of PI3K in VSMCs by expression of a dominant negative p85alpha mutant lacking the p 110 binding domain ( Deltap 85 ) , or by treatment of cells with LY 294002 , inhibited Ang 2 stimulated PAI 1 ( plasminogen activator inhibitor 1 ) mRNA expression . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The addition of plasminogen activator inhibitor Type 1 ( PAI 1 ) to cells increased the P 25 induced fibronectin polymerization , as well as the number of activated integrins . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the subgroup of 206 obese children , albumin excretion rate , plasma uric acid , fibrinogen , plasminogen activator inhibitor type 1 ( PAI 1 ) , C reactive protein , interleukin 6 and white blood cells were also measured . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the absence of TGF beta 1 , the expression of thrombomodulin , the plasminogen activators u PA and t PA , and their inhibitor PAI 1 was significantly increased in the S / G2 compared to the G 1 phase . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Angiotensinogen has been implicated in hypertension and plasminogen activating inhibitor 1 ( PAI 1 ) in impaired fibrinolysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Levels of total cholesterol , triglyceride , free fatty acid ( FFA ) , fibrinogen , and plasminogen activator inhibitor 1 ( PAI 1 ) were significantly decreased after GH treatment . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We studied levels of major plasminogen activator inhibitor 1 ( PAI 1 ) , tissue type plasminogen activator ( tPA ) , and urokinase type plasminogen activator ( uPA ) in lungs of preterm infants with RDS . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We studied in the Insulin Resistance Atherosclerosis Study the relation of incident diabetes to dynamic changes of plasminogen activator inhibitor 1 ( PAI 1 ) and fibrinogen . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A cross sectional study was therefore performed in 107 type 2 diabetic patients recruited from the Denver Metropolitan Area to examine the effect of impaired fibrinolysis , as assessed by the ratio of plasminogen activator inhibitor ( PAI 1 ) to tissue type plasminogen activator ( t PA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor type 1 ( PAI 1 ) , the primary inhibitor of plasminogen activators , also forms high molecular weight complexes with either thrombin or factor Xa ( FXa ) in the presence of heparin , resulting in the loss of mutual activities of enzyme and inhibitor . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Sequence variants of angiotensin converting enzyme ( ACE ) insertion / deletion ( I / D ) , angiotensinogen ( AGT ) T235M , angiotensin 2 type 1 receptor ( AT1R ) A1166C , and plasminogen activator inhibitor 1 ( PAI 1 ) 4G / 5G were analyzed to see their genetic associations with vascular dementia as its candidate genetic risk factors involving renin angiotensin and fibrin systems . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The central components of the PA system are the proteolytic activators , urokinase plasminogen activator ( u PA ) and tissue type plasminogen activator ( t PA ) , plasminogen ( plg ) and its degradation product , plasmin , together with the major inhibitors of this system , plasminogen activator inhibitor 1 and 2 ( PAI 1 , PAI 2 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : In endotoxemia , plasminogen activator inhibitor 1 ( PAI 1 ) increases and develops clinical symptoms by suppressing fibrinolysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The type 1 plasminogen activator inhibitor ( PAI 1 ) is the major physiological regulator of plasminogen activation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In contrast , plasminogen activator inhibitor 1 ( PAI 1 ) dose dependently reduced morphine induced dopamine release . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
These secreted proteins , which include tumor necrosis factor ( TNF ) alpha , resistin , IL 6 , IL 8 , acylation stimulating protein ( ASP ) , angiotensinogen , plasminogen activator inhibitor 1 ( PAI 1 ) ( `` bad ' ' adipokines ) and leptin , adiponectin ( `` good ' ' adipokines ) seem to play important regulatory roles in a variety of complex processes , including fat metabolism , feeding behavior , hemostasis , vascular tone , energy balance , and insulin sensitivity , but none is without controversy regarding its respective mechanism and scope of action . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Citrated plasma blood samples were taken before and 30 minutes after a maximal exercise treadmill test , and levels of tissue type plasminogen activator ( t PA ) antigen , plasminogen activator inhibitor ( PAI 1 ) antigen and lipoprotein a , Lp ( a ) , [ all ELISA ] were measured as indices of fibrinolytic function . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor type 1 ( PAI 1 ) is the major negative regulator of the plasmin dependent pericellular proteolytic cascade . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To test the hypothesis that plasminogen activator inhibitor 1 ( PAI 1 ) may serve as a candidate marker for the malignancy of gastric cancer , we carried out quantitative reverse transcription polymerase chain reaction for the PAI 1 gene and evaluated the possible relationship between PAI 1 gene expression levels and clinicopathological findings in gastric cancer . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In this study we investigated the relationship between von Willebrand factor ( vWF ) and visceral adipose tissue ( VAT ) in a group of 181 overweight and obese premenopausal women visiting the weight management clinic of a university hospital . von Willebrand factor antigen ( vWF : Ag ) , plasminogen activator inhibitor 1 ( PAI 1 ) activity , VAT ( computed tomography scan ) , insulin resistance ( homeostasis model assessment of insulin resistance ) , and other anthropometric and metabolic parameters were measured . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The effects of NaB on TGF beta induced Smad 3 phosphorylation and plasminogen activator inhibitor 1 ( PAI 1 ) and cyclooxygenase 2 ( COX 2 ) gene expression were also examined in RIE 1 cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
MATERIALS AND METHODS : Three months after delivery we investigated the plasma levels of plasminogen activator inhibitor type 1 ( PAI 1 ) , tissue plasminogen activator ( t PA ) , fibrinogen and von Willebrand factor ( vWF ) in 74 women with p GDM and 20 healthy females with normal glucose tolerance during and after pregnancy , as well as the relation of fibrinolytic parameters to insulin resistance and glycaemic control . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Patients with CHD were older , had a higher body mass index , and higher levels of total cholesterol , glucose , plasminogen activator inhibitor 1 ( PAI 1 ) , tissue plasminogen activator ( t PA ) antigen , and fibrinogen ; 47 % were treated for hypertension . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The procoagulant and fibrinolytic states were assessed in 46 patients with acute stroke by measuring plasma levels of plasminogen activator inhibitor 1 ( PAI 1 ) , thrombin antithrombin complex ( TAT ) , and plasminogen antiplasmin complex ( PAP ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) was assayed in supernatants . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : Blood levels of sialylated carbohydrate antigen KL 6 , TGF beta , endothelin 1 ( ET 1 ) , thrombomodulin ( TM ) , and plasminogen activator inhibitor 1 ( PAI 1 ) were determined in 43 patients with PM or DM with or without IP , and the relationship between these measures was analyzed . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) , a member of the serine protease inhibitor superfamily , modulates fibrinolysis by interacting with proteolytic mediators , including urokinase plasminogen activator ( uPA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We conducted a randomized trial to assess the effects of lercanidipine and losartan on blood pressure ( BP ) lowering and three fibrinolytic parameters : plasminogen activator inhibitor 1 ( PAI 1 ) , D dimer , and fibrinogen . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The effect of high plasma levels of angiotensin converting enzyme ( ACE ) and plasminogen activator inhibitor ( PAI 1 ) on the reperfusion after thrombolytic therapy in patients presented with acute myocardial infarction . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We used semi quantitative reverse transcriptase polymerase chain reaction to detect the expression of TGFbeta 1 , fibronectin ( FN ) , collagen 1 , and plasminogen activator inhibitor type 1 ( PAI 1 ) mRNA by the stimulated cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
AIMS : PAI 1 ( plasminogen activator inhibitors 1 ) regulates plasminogen activation , and is related to tumour development . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : Including 21 patients , the following markers were measured preoperatively and on postoperative day 1 , 2 , 3 , 7 , 14 , and 21 : Activation products of coagulation : thrombin antithrombin complex ( TAT ) , thrombus precursor protein ( TPP ) , and prothrombin fragment F1+2 ( F1+2 ) , and markers of fibrinolysis : plasmin alpha ( 2 ) antiplasmin complexes ( PAP ) , D Dimer , tissue plasminogen activator ( t PA ) antigen , and plasminogen activator inhibitor 1 ( PAI 1 ) antigen . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma von Willebrand factor antigen ( vWF : Ag ) , thrombomodulin , tissue type plasminogen activator ( t PA ) and its inhibitor ( PAI 1 ) , and D dimer were determined by immunoenzymatic assay at baseline , and at 6 , 12 , and 18 months . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have shown previously that increased expression of plasminogen activator inhibitor type 1 ( PAI 1 ) limits VSMC apoptosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To investigate the ability of bone marrow ( BM ) derived cells to modulate neointimal growth after injury by expressing plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma tissue plasminogen activator ( t PA ) / plasminogen activator inhibitor 1 ( PAI 1 ) complex was decreased by treatment from 21 . 7 + 8 . 6 ng / ml to 19 . 0 + / 6 . 6 ng / ml ( F = 8 . 784 , p < 0 . 001 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : Meta analyses were done of 191 studies in relation to factor 5 G1691A ( ie , factor 5 Leiden ) , factor 7 G10976A , prothrombin G20210A , plasminogen activator inhibitor 1 ( PAI 1 ) [ 675 ] 4G / 5G , and three platelet glycoprotein ( GP ) receptor variants ( GPIa C807T , GPIbalpha T [ 5 ] C , GPIIIa C1565T ) , involving a total of 66 155 coronary disease cases and 91 307 controls . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND AND PURPOSE : The gene encoding plasminogen activator inhibitor type 1 ( PAI 1 ) has a common 4G / 5G ' functional ' polymorphism , and people homozygous for the 4G allele have higher PAI 1 plasma concentrations . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : Elevated plasma levels of plasminogen activator inhibitor 1 ( PAI 1 ) are observed in patients with obesity , hypertension and diabetes , and several observations suggest that PAI 1 mediates diabetic vascular complications . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Previous data indicate that carbon dioxide increases release and expression of plasminogen activator inhibitor type 1 ( PAI 1 ) and induces acidification . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Increased plasminogen activator inhibitor type 1 ( PAI 1 ) in the heart as a function of age . ^^^ Plasminogen activator inhibitor type 1 ( PAI 1 ) has been strongly implicated as a determinant of fibrosis in diverse organs and tissues . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To determine whether insulin resistance increases expression of plasminogen activator inhibitor type 1 ( PAI 1 ) in the heart , studies were performed in 22 mice with and 38 without myocardial infarction . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Biological markers showed a decrease in thrombin generation and in plasminogen activator inhibitor 1 ( PAI 1 ) and a return of TAFI to a normal value . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : We investigated paraoxonase 2 ( PON 2 ) Ser311Cys , lipoprotein lipase ( LPL ) Asn291Ser , plasminogen activator inhibitor 1 ( PAI 1 ) T11053G , beta fibrinogen ( FGB ) 455 G > A and nitric oxide synthase gene ( NOS ) 922 A > G polymorphisms in 84 patients with FH . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Activities and concentrations of tissue plasminogen activator ( tPA ) , plasminogen activator inhibitor type 1 ( PAI 1 ) , tPA / PAI 1 complex and hydroxyproline contents were determined . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue plasminogen activator ( t PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) in children with ulcerative colitis ] . ^^^ The aim of the study was the assessment of tissue plasminogen activator ( t PA ) and its inhibitor ( PAI 1 ) in children with ulcerative colitis . ^^^ In the group of children with ulcerative colitis under investigation a mean concentration of antigen inhibitor plasminogen activator ( PAI 1 : Ag ) was statistically higher . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We measured body mass index , blood pressure , total cholesterol , low density lipoprotein and high density lipoprotein cholesterol , triglycerides , fasting plasma glucose , glycosylated hemoglobin A ( 1c ) , insulin , creatinine , uric acid , high sensitive C reactive protein , plasminogen activator inhibitor 1 ( PAI 1 ) , and fibrinogen . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The role of plasminogen activator inhibitor 1 ( PAI 1 ) in angiogenesis remains controversial . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) gene polymorphism ( 675 4G / 5G ) associated with obesity and vascular risk in children . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor ( PAI 1 ) is an important component of the plasminogen / plasmin system as it is the main inhibitor of tissue type ( t PA ) and urokinase type plasminogen activator ( u PA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tatpep 5 , 15 , and 16 increased the endogenous levels of the pro angiogenic transcription factors c Jun and SP 1 as well as the production of the plasminogen activator inhibitor 1 ( PAI 1 ) by HUVEC . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The increased plasma t PA ag in persons with carotid stenosis was not associated with increased plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The functions of the serpin PAI 1 ( plasminogen activator inhibitor 1 ) are based on molecular interactions with its target proteases uPA and tPA ( urokinase type and tissue type plasminogen activator respectively ) , with vitronectin and with endocytosis receptors of the low density lipoprotein family . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fibrinolysis is modulated by several factors , and polymorphisms in the plasminogen activator inhibitor 1 ( PAI 1 ) gene are considered to be one of the important determinants . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : Diabetes is associated with an excess risk of cardiac events , and one risk factor for infarction is an elevated level of plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The aim of our study was to assess the impact of WCH on fibrinolytic balance and endothelial function by measuring plasma levels of plasminogen activator inhibitor 1 ( PAI 1 ) , tissue plasminogen activator antigen ( tPA ) , fibrinogen , and thrombomodulin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasmin , tissue plasminogen activator ( tPA ) , and urokinase plasminogen activator ( uPA ) activity , plasminogen activator inhibitor 1 ( PAI 1 ) , and alpha 2 antiplasmin ( alpha2AP ) antigen were measured in the AAA wall and juxtamural and luminal aspects of intraluminal thrombus in 18 patients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
COX 2 ) or fibrinolysis inhibitors ( e . g . plasminogen activator inhibitor , type 1 [ PAI 1 ] ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Increased plasminogen activator inhibitor 1 ( PAI 1 ) activity is associated with greater risk of myocardial infarction . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : A PubMed / MEDLINE search of English language articles ( 1990 to February 2006 ) with the terms angiotensin 2 antagonists or AIIAs or angiotensin receptor blockers or losartan or atenolol or beta blocker and terms including , but not limited to , atherosclerosis , left ventricular hypertrophy , carotid artery hypertrophy , fatty streaks , atrial fibrillation , arrhythmias , endothelial function , myocyte hypertrophy , myocardial fibrosis , platelet aggregation , tissue factor , plasminogen activator inhibitor 1 , PAI 1 , anti inflammatory , uric acid , or oxidative stress . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Here , we report that suppression of the p 53 target gene encoding plasminogen activator inhibitor 1 ( PAI 1 ) by RNA interference ( RNAi ) leads to escape from replicative senescence both in primary mouse embryo fibroblasts and primary human BJ fibroblasts . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The inflammatory factor C reactive protein ( CRP ) and the fibrinolytic variables fibrinogen and plasminogen activator 1 ( PAI 1 ) are associated with long term cardiovascular morbidity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Subjects had tissue plasminogen activator ( t PA ) antigen levels and activity and plasminogen activator inhibitor 1 ( PAI 1 ) activity measured before and after 6 mo of endurance exercise training . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : We investigated whether the ratio of oleic to palmitic acid [ and that of monounsaturated to saturated fatty acids ( MUFA : SFA ) ] in the diet affects postprandial concentrations of triacylglycerols , tissue factor ( TF ) , fibrinogen , tissue type plasminogen activator ( t PA ) , and plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Between 2000 to 2004 , polymorphisms of the following genes and their association to metabolic parameters and late complications of diabetes were examined in the authors ' laboratory : PAI 1 ( plasminogen activator inhibitor 1 ) , PPARgamma 2 ( peroxisome proliferator activated receptor gamma 2 ) , UCP 1 ( uncoupling protein 1 ) , and adiponectin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In rectal tumors , there was an increased activity of uPA compared with the activity in colon tumors ( P = 0 . 0266 ) , however urokinase type plasminogen activator receptor ( uPAR ) and plasminogen activator inhibitor 1 ( PAI 1 ) showed no significant difference between colon and rectal cancer tissues . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Furthermore , LDLs have been implicated in the induction of changes in permeability , cell adhesion and secretion of vasoactive molecules ( nitric oxide [ NO ] ) , while VLDLs seem to modulate the fibrinolytic system [ tissue plasminogen activator ( TPA ) and plasminogen activator inhibitor 1 ( PAI 1 ) ] . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
During the next 24 hours when the cells were cultured in standard medium synthesis of interleukin 6 ( IL 6 ) , tissue plasminogen activator ( t PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) were studied . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Over expression of uPA in the VTA induces doxycycline dependent expression of its receptor , uPAR , but not its inhibitor , plasminogen activator inhibitor 1 ( PAI 1 ) . uPAR expression in the VTA is repressed upon silencing of uPA with lentiviruses expressing siRNAs . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A hexapeptide ( EEIIMD ) corresponding to amino acids 350 355 of plasminogen activator inhibitor type 1 ( PAI 1 ) abolished the tPA induced increase in infarct size and intracranial bleeding in both mechanical and embolic models of stroke in rats , and reduced brain edema and neuronal loss after traumatic brain injury in pigs . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The expression levels of tissue type plasminogen activator ( t PA ) , bone carboxyglutamate protein ( BGP ) , c sis , and an unknown protein were downregulated in the sera of patients with IONFH , whereas the other 3 proteins , including plasminogen activator inhibitor type 1 ( PAI 1 ) , crosslaps , and anti p 53 antibody , were upregulated . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Notably , hearts from t PA null mice released much less NE upon EFS than their wild type ( WT ) controls ( i . e . , a 76 . 5 % decrease ; P < 0 . 01 ) , whereas hearts from plasminogen activator inhibitor 1 ( PAI 1 ) null mice released much more NE ( i . e . , a 275 % increase ; P < 0 . 05 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : One of the most thoroughly studied systems in relation to its prognostic relevance in patients with breast cancer , is the plasminogen activation system that comprises of , among others , the urokinase Plasminogen Activator ( uPA ) and its main inhibitor , the Plasminogen Activator Inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We selected biomarkers from 4 biological domains : neurohormonal ( N terminal pro atrial natriuretic peptide [ N ANP ] , B type natriuretic peptide [ BNP ] , renin , aldosterone ) , hemostatic factors ( plasminogen activator inhibitor 1 [ PAI 1 ] ) , inflammation ( C reactive protein [ CRP ] ) , and target organ damage ( urine albumin creatinine ratio ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Both hyperglycemia and hyperinsulinemia induce prothrombotic characteristics , including overexpression of vascular endothelial plasminogen activator inhibitor 1 ( PAI 1 ) , down regulation of fibrinolysis , elevation of plasma coagulation proteins ( ie , fibrinogen , factor 7 , factor 10 ) , and enhanced platelet activation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
RESULTS : Group assignment was not found to be a determinant of waist circumference , high sensitive C reactive protein ( hs CRP ) , fibrinogen , von Willebrand factor ( vWF ) , plasminogen activator inhibitor type 1 ( PAI 1 ) activity , tissue plasminogen activator ( tPA ) activity , tPA antigen , tPA PAI 1 complex , leptin , or HOMA 2 insulin resistance index ( HOMA 2 IR ) at follow up . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue factor ( TF ) and plasminogen activator inhibitor 1 ( PAI 1 ) activity and / or expression are upregulated in hypercholesterolemia . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Finally , plasminogen activator inhibitor 1 ( PAI 1 ) activity was reduced by exercise relative to the control group ( P = . 03 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : The effect of a novel small molecule plasminogen activator inhibitor ( PAI 1 ) inhibitor on adipose tissue physiology was investigated . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Oxidized low density lipoprotein ( Ox LDL ) stimulates plasminogen activator inhibitor 1 ( PAI 1 ) expression in human mesangial cells mediated by transforming growth factor beta ( TGF beta ) / Smad signaling pathway . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue plasminogen activator ( t PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) directly influence thrombus formation and degradation and thus risk for arterial thrombosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
MAIN OUTCOME MEASURE ( S ) : Real time reverse transcriptase polymerase chain reaction expression of messenger RNA tissue plasminogen activator ( tPA ) , plasminogen activator inhibitor 1 ( PAI 1 ) , and tPA PAI 1 ratio , an indicator of overall fibrinolytic activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
PURPOSE : Plasminogen activator inhibitor 1 ( PAI 1 ) plays an important role in cancer invasion and metastasis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Above normal plasma levels of thrombin antithrombin 3 complex , fibrinopeptide A , FDP D dimer , plasminogen activator inhibitor 1 , and thrombomodulin were found in the patients before treatment ; each of these was reduced significantly during treatment . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Von Willebrand factor , plasminogen activator inhibitor 1 and C reactive protein are markers of thrombolytic efficacy in acute myocardial infarction . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Platelet derived growth factor increases plasminogen activator inhibitor 1 activity and mRNA in rat cultured vascular smooth muscle . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Studies in cell culture systems have found that Lp ( a ) stimulates endothelial cells to synthesize and release plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To study the patterns of plasma concentrations of endotoxin , tumor necrosis factor alpha ( TNF ) , interleukin 6 ( IL 6 ) , plasminogen activator inhibitor 1 , C reactive protein , and serum amyloid A during the treatment of human sepsis . ^^^ The septic group showed significantly ( p less than . 05 ) higher concentrations of TNF , IL 6 , plasminogen activator inhibitor 1 , C reactive protein , and serum amyloid A compared with the nonseptic patients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Zymography of serial plasma samples from the bat PA treated dogs failed to demonstrate the apparent generation of a complex between bat PA and plasminogen activator inhibitor 1 ; the corresponding complex with t PA was observed in plasma samples from the t PA treated dogs . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Conversion of single chain to two chain forms of u PA or inhibition of active two chain forms with plasminogen activator inhibitor 1 or with the active site serine inhibitor phenyl methyl sulfonyl fluoride , did not alter the reactivity in the assay . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Exercise beyond the anaerobic threshold did not change plasminogen activator inhibitor 1 activities . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
VN is incorporated into several complexes , such as the terminal complement complex and thrombin antithrombin 3 , and is bound to plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We determined the correlations between Lp ( a ) and other blood lipids ( serum cholesterol , LDL cholesterol , HDL cholesterol , triglycerides ) , coagulation parameters ( fibrinogen , factor 7 , factor 8 : C fibrin monomers , thrombin antithrombin 3 ) and fibrinolysis parameters ( tissue plasminogen activator antigen , plasminogen activator inhibitor 1 and D dimer ) in 54 patients with essential hypertension , in 65 non insulin dependent diabetic patients and in 116 insulin regulated diabetic patients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Concentrations of alpha 2 antiplasmin and plasminogen activator inhibitor 1 tended to be higher in the lavage of oleic acid / Pseudomonas baboons with low fibrinolytic activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In a multiple linear regression analysis fibrinolytic variables , euglobulin clot lysis time and plasminogen activator inhibitor 1 , were shown to have predictive value regarding outcome of surgery ; that is , normal fibrinolytic activity favors a satisfactory outcome and vice versa . ^^^ Body mass index , gamma glutamyl transpeptidase , triglycerides and smoking were of statistical significance in relation to euglobulin clot lysis time and plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
LIF also acts directly on osteoblasts to inhibit plasminogen activator activity , by stimulating the synthesis of plasminogen activator inhibitor 1 mRNA and protein . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Activated Partial Thromboplastin Time , Prothrombin Time , Fibrinogen , Factor 7 , Antithrombin 3 , Protein C , Plasminogen , alpha 2 Plasmin Inhibitor , Plasminogen Activator Inhibitor 1 , tissue Plasminogen Activator were functionally evaluated . ^^^ Compared to the control group diabetic patients displayed significantly higher levels of Fibrinogen ( p < 0 . 01 ) , Factor 7 ( p < 0 . 01 ) , Thrombin Antithrombin complexes ( p < 0 . 01 ) and Plasminogen Activator Inhibitor 1 activity ( p < 0 . 01 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Decreases in fasting blood glucose ( P < 0 . 001 ) , cholesterol ( P < 0 . 001 ) , triglycerides ( P < 0 . 05 ) , plasminogen activator inhibitor 1 activity ( P < 0 . 01 ) , systolic blood pressure ( P < 0 . 01 ) , and diastolic blood pressure ( P < 0 . 001 ) were seen during guar treatment when compared with placebo . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Only small amounts of fibrinogen , factor 8 : c , plasminogen , antithrombin 3 , fibrin monomers and plasminogen activator inhibitor 1 were detected in seminal plasma . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Effect of endothelin on the release of tissue plasminogen activator and plasminogen activator inhibitor 1 from cultured human endothelial cells and interaction with thrombin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Hirudin was slightly more potent than DuP 714 in inhibiting thrombin induced aggregation in washed human platelets ( IC50s of 72 nM and 150 nM , respectively ) and in inhibiting the secretion of plasminogen activator inhibitor 1 from human platelets ( IC50s of 300 nM and 900 nM , respectively ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Factor 7 and plasminogen activator inhibitor 1 look promising as risk factors in the middle aged , but there are no data currently available concerning the status of these factors in the elderly . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The impairment of the endogenous fibrinolysis activity could be attributed either to a defective release of plasminogen activator from the vessel wall ( 67 % of patients ) or to high plasma levels of plasminogen activator inhibitor 1 ( 33 % of patients ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In another model system of human HT 1080 fibroblasts differentiating in the presence of dexamethasone , we demonstrated enhanced repair in the gene for plasminogen activator inhibitor 1 whose transcription is induced and , correspondingly , a reduced repair rate in the urokinase plasminogen activator gene whose transcription is suppressed . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Patients were examined less than or equal to 7 days after cerebral infarction and evaluated for fibrinogen , anticardiolipin antibodies , fibrin D dimer ( a fragment of cross linked fibrin ) , plasminogen activator inhibitor 1 , and protein S . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Comparison of recombinant plasminogen activator inhibitor 1 and epsilon amino caproic acid in a hemorrhagic rabbit model . ^^^ A rabbit ear model of blood loss was developed to compare the effects of an active form of recombinant plasminogen activator inhibitor 1 ( rPAI 1 ) with epsilon amino caproic acid ( EACA ) in antagonizing tissue type plasminogen activator ( r tPA ) induced blood loss . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The expression of their inhibitors , the tissue inhibitor of metalloproteinases ( TIMP ) and plasminogen activator inhibitor 1 , preceded the onset of ECM degrading proteinase expression and was detected by day two of involution , and showed a sharp peak of expression centered on days 4 6 of involution . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Reactivated recombinant plasminogen activator inhibitor 1 ( rPAI 1 ) effectively prevents thrombolysis in vivo . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 activity in plasma increased significantly , from 21 . 79 + / 1 . 29 arbitrary units / ml ( AU / ml ) at baseline study to 32 . 05 + / 1 . 47 AU / ml at 6 h after vessel wall injury ( p less than 0 . 01 ) , whereas activity remained unchanged throughout the 24 h period in the control group . ^^^ In addition to other procoagulant factors , elevated plasminogen activator inhibitor 1 activity may lead to intravascular thrombosis and impaired resolution of thrombus . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A concurrent increase in the levels of the fibrinolytic inhibitors plasminogen activator inhibitor 1 and 2 from 7 . 4 to 37 . 8 AU / mL and 31 to 160 micrograms / L , respectively , suggests a decrease in fibrinolytic activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 plasma levels and coronary restenosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have recently shown that alveolar epithelial cells may control fibrinolysis by expressing both urokinase type plasminogen activator ( uPA ) and plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 production was not detected in any of the four experimental groups . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Occasional macrophage like cells also stained for urokinase but tissue type plasminogen activator and plasminogen activator inhibitor 1 were restricted to vascular endothelium . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have previously reported that tumor necrosis factor alpha ( TNF alpha ) enhances expression of interleukin 6 , collagenase , plasminogen activator inhibitor 1 , and basic fibroblast growth factor genes in human omental microvascular endothelial ( HOME ) cells in culture . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The finding of plasminogen activator inhibitor 1 in the pericapillary cuff in several cases may indicate that breakdown of this fibrin cuff is impaired . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Protein C may inhibit thrombin formation and also complex with plasminogen activator inhibitor 1 , thereby promoting fibrinolysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The release of TM antigen was not influenced by addition of various concentrations ( 0 . 01 5 . 0 microM ) of monensin , which inhibits intracellular transport of secretory proteins , though the secretion of plasminogen activator inhibitor 1 from the cells was inhibited . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
HGF did not efficiently enhance expression of both the t PA gene and a tissue inhibitor of metalloproteinase gene whereas it stimulated expression of plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fibrinogen and plasminogen activator inhibitor 1 levels in hypertension and coronary heart disease . ^^^ The roles of fibrinolysis , fibrinogen , and plasminogen activator inhibitor 1 in the development of coronary heart disease are reviewed , and possible effects of long term treatment with beta blockade are discussed . ^^^ Recently , it has also been shown that high levels of fibrinogen and plasminogen activator inhibitor 1 are predictors for myocardial infarction . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The antibody had no effect on the activity of rtcu PA or on its inhibition by a chloromethylketone , but reduced the inhibition of rtcu PA by recombinant plasminogen activator inhibitor 1 ( rPAI 1 ) at least 10 fold . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Vitronectin endows plasminogen activator inhibitor 1 with thrombin inhibitory properties . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Complex formation between plasminogen activator inhibitor 1 and vitronectin in purified systems and in plasma . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Metformin causes a reduction in basal and post venous occlusion plasminogen activator inhibitor 1 in type 2 diabetic patients . ^^^ In the metformin treated patients basal plasminogen activator inhibitor 1 antigen ( PAI 1Ag ) fell from 57 . 4 micrograms l 1 before treatment to 36 . 1 ( p less than 0 . 05 ) and 41 . 0 micrograms l 1 ( p less than 0 . 01 ) after 3 and 6 weeks therapy . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Grey platelet syndrome : evidence for alpha granule localization of the platelet plasminogen activator inhibitor 1 pool . ^^^ The plasminogen activator inhibitor 1 pool in the patient ' s platelets was 5 % of normal , confirming previous indirect evidence for the storage of this protein within the alpha granule . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Inasmuch as the mesothelial cells also released plasminogen activator inhibitor 1 , as do human umbilical vein endothelial cells , we could not detect u PA activity in culture medium . u Pa may play a role in the protection against adhesion among visceral organs . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Antigen levels of both tissue type plasminogen activator and plasminogen activator inhibitor 1 were increased in mild and severe cirrhosis . ^^^ In most patients , the increase in tissue type plasminogen activator was counterbalanced by the increased levels of plasminogen activator inhibitor 1 , but in a subgroup of patients the change in balance resulted in extremely high tissue type plasminogen activator levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Glucocorticoid regulation of plasminogen activator inhibitor 1 messenger ribonucleic acid and protein in normal and malignant rat osteoblasts . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Vascular endothelial growth factor ( VEGF ) induces plasminogen activators and plasminogen activator inhibitor 1 in microvascular endothelial cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
CA 77 cells were transfected with expression vectors encoding protease inhibitors : the Arg serpins , alpha 1 antitrypsin Pittsburgh ( 358 Met Arg ) and plasminogen activator inhibitor 1 , the Kazal type serine protease inhibitor , pancreatic secretory trypsin inhibitor , and the general thiol protease inhibitor , cystatin C . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Two patients had changes in the fibrinolytic system ( high plasminogen activator inhibitor 1 levels ) and 2 in the natural anticoagulants ( low antithrombin 3 activity ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This fibrinolytic defect appeared attributable to disproportionate increases in circulating plasminogen activator inhibitor 1 levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Moreover , these hybrids regain full responsiveness to TGF beta 1 , as measured by inhibition of DNA synthesis as well as stimulation of fibronectin and plasminogen activator inhibitor 1 production . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 levels determine the profibrinolytic response in disseminated intravascular coagulation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The release of tissue plasminogen activator and tissue plasminogen activator inhibitor 1 antigens decreased at a concentration of 7 beta hydroxycholesterol lower than that required for reducing general protein synthesis . 7 beta Hydroxycholesterol at 50 mumol / l first increased the release and then ( at 100 mumol / l ) inhibited the synthesis of von Willebrand factor . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
On the reversible interaction of plasminogen activator inhibitor 1 with tissue type plasminogen activator and with urokinase type plasminogen activator . ^^^ The reaction between plasminogen activators and plasminogen activator inhibitor 1 is characterized by an initial rapid formation of an inactive reversible complex . ^^^ The second order association rate constant ( k 1 ) of complex formation of recombinant two chain tissue type plasminogen activator ( rt PA ) or recombinant two chain urokinase type plasminogen activator ( rtcu PA ) by recombinant plasminogen activator inhibitor 1 ( rPAI 1 ) is 2 . 9 + / 0 . 4 10 10 ( 7 ) M 1 s 1 ( mean + / S . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Rat alveolar epithelial cells concomitantly express plasminogen activator inhibitor 1 and urokinase . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 in human carcinoma tissues . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The synthesis of another serum induced protein , the plasminogen activator inhibitor 1 was blocked during concurrent and delayed ( after 3 h of stimulation ) treatment of serum stimulated fibroblasts with DMSO . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Increased plasma plasminogen activator inhibitor 1 levels . ^^^ According to recent prospective studies , hypofibrinolysis due to elevated plasma plasminogen activator inhibitor 1 levels appears to be an independent risk factor for myocardial reinfarction in men , and hyperinsulinaemia , a major indicator of insulin resistance is considered as a risk factor for coronary disease . ^^^ It has recently been shown that insulin resistance is accompanied by an increased plasma plasminogen activator inhibitor 1 concentration : A significant correlation coefficient was demonstrated between plasminogen activator inhibitor 1 and fasting plasma insulin in the normal population , in obese subjects , in Type 2 ( non insulin dependent ) diabetic patients and in angina pectoris . ^^^ Attempts to decrease insulin resistance such as fasting , diet , or administration of an oral anti diabetic drug such as Metformin induced a parallel decrease in plasma insulin and plasminogen activator inhibitor 1 levels . ^^^ Plasminogen activator inhibitor 1 synthesis by hepatocytes in culture was stimulated by an increasing insulin concentration , or low density lipoproteins , whereas the endothelial cell synthesis was stimulated by very low density lipoproteins especially when they were obtained from hypertriglyceridaemic patients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The four other genes were all induced by TGF beta and correspond to the genes of collagen alpha type 1 , fibronectin , plasminogen activator inhibitor 1 , and the monocyte chemotactic cell activating factor ( JE gene ) previously shown to be TGF beta regulated . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Unlike endothelial cells where plasminogen activator inhibitor 1 has been implicated in mediating a high affinity interaction of t PA with the cells , no evidence for a role of this inhibitor in ligand binding to the monocytoid cells was found . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 , not detectable in control peritoneum , was present in inflamed tissue and might be the reason for the reduction in functional fibrinolytic activity . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
TGF beta 1 addition to exponentially growing Mv1Lu cells increased the levels of junB mRNA and of three extracellular matrix proteins : plasminogen activator inhibitor 1 , fibronectin , and thrombospondin . ^^^ Kinetically , the effects on junB and plasminogen activator inhibitor 1 expression occurred faster ( half maximal at 1 to 2 h ) than the effects on fibronectin and thrombospondin expression ( half maximal at 6 to 10 h ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Angiotensin 2 induces secretion of plasminogen activator inhibitor 1 and a tissue metalloprotease inhibitor related protein from rat brain astrocytes . ^^^ N terminal amino acid sequencing indicates that AISP 55K is identical to rat plasminogen activator inhibitor 1 , whereas AISP 30K exhibits 72 81 % identity to three closely related proteins : human tissue inhibitor of metalloproteases , a rat phorbol ester induced protein , and the murine growth responsive protein 16C8 . ^^^ Immunofluorescent staining with rat plasminogen activator inhibitor 1 antibody was induced in the majority of cells in culture after Ang 2 treatment of astrocytes from 21 day old rat brains . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Human S protein is a serum glycoprotein that binds and inhibits the activated complement complex , mediates coagulation through interaction with antithrombin 3 and plasminogen activator inhibitor 1 , and also functions as a cell adhesion protein through interactions with extracellular matrix and cell plasma membranes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A spectroscopic study of the conformations of active and latent forms of recombinant plasminogen activator inhibitor 1 . ^^^ Recombinant plasminogen activator inhibitor 1 ( rPAI 1 ) purified from Escherichia coli , like its natural counterpart , can exist in either active or latent form . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Structural determinants of the noncatalytic chain of tissue type plasminogen activator that modulate its association rate with plasminogen activator inhibitor 1 . ^^^ In order to identify the regions of recombinant ( r ) tissue plasminogen activator ( tPA ) that mediate its kinetically relevant interaction with r plasminogen activator inhibitor 1 ( rPAI 1 ) , we have determined the second order association rate ( k 1 ) constants of domain altered variants of tPA with rPAI 1 , at 10 degrees C . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Normal plasma levels of tPA , urokinase and plasminogen activator inhibitor 1 were found by ELISA , and tPA antigen levels rose after desmopressin acetate infusion . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The recombinant peptide , which concentrated in cytoplasmic inclusion bodies , was isolated , solubilized , chemically refolded , and purified by affinity chromatography on lysine Sepharose to apparent homogeneity . [ 35S ] Cysteine methionine labeled polypeptide was used to study the interactions of kringle 2 with lysine , fibrin , and plasminogen activator inhibitor 1 . ^^^ We also observed that kringle 2 forms a complex with highly purified guanidine activated plasminogen activator inhibitor 1 , dissociable by 0 . 2 M epsilon aminocaproic acid . ^^^ The kringle 2 polypeptide significantly inhibited tissue plasminogen activator / plasminogen activator inhibitor 1 interaction . ^^^ The kringle 2 domain bound to plasminogen activator inhibitor 1 in a specific and saturable manner with a Kd = 0 . 51 + / 0 . 055 microM ( 0 . 35 + / 0 . 026 binding site ) . ^^^ Therefore , the t PA kringle 2 domain is important for the interaction of t PA not only with fibrin , but also with plasminogen activator inhibitor 1 and thus represents a key structure in the regulation of fibrinolysis . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Early coronary reperfusion blunts the procoagulant response of plasminogen activator inhibitor 1 and von Willebrand factor in acute myocardial infarction . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Effect of peptides on the inactivation of tissue plasminogen activator by plasminogen activator inhibitor 1 and on the binding of tissue plasminogen activator to endothelial cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
No correlation between beta thromboglobulin and plasminogen activator inhibitor type 1 antigen in platelet poor plasma was observed , but a significant inverse correlation ( r = 0 . 78 , p less than 0 . 05 ) between beta thromboglobulin in platelet poor plasma and plasminogen activator inhibitor 1 antigen in platelet lysate was obtained in preeclamptic patients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fibrinolytic activity was measured using assays for fibrinopeptide B beta 1 42 and plasminogen activator inhibitor 1 . ^^^ Plasminogen activator inhibitor 1 was normal acutely ( 20 . 1 + / 12 . 0 ng / mL ; n = 73 ) but increased at follow up ( 27 . 8 + / 20 . 1 ng / mL ; n = 45 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The addition to the keratinocyte culture medium of the urokinase A chain can stimulate a concentration dependent urokinase oversecretion , which is not paralleled by oversecretion of plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Short term infusions of insulin , triacylglycerol and glucose do not cause acute increases in plasminogen activator inhibitor 1 concentrations in man . 1 . ^^^ To investigate the acute effects of insulin and triacylglycerol ( ' triglyceride ' ) on circulating plasminogen activator inhibitor 1 concentrations , seven healthy volunteers were studied during hyperinsulinaemic clamps in the presence of euglycemia ( mean glucose concentration 5 mmol / l ) and hyperglycaemia ( mean glucose concentration 9 mmol / l ) with and without triacylglycerol infusions . 2 . ^^^ Concentrations of plasminogen activator inhibitor 1 fell from 27 . 5 ( 10 47 ) ng / ml to 25 . 0 ( 14 . 5 55 ) ng / ml and 15 . 5 ( 11 . 5 28 . 5 ) ng / ml ( P less than 0 . 02 ) over the same time . 3 . ^^^ Concentrations of plasminogen activator inhibitor 1 again showed a gradual fall from 24 . 7 ( 22 50 ) ng / ml to 14 ( 8 . 3 25 . 5 ) ng / ml and 13 ( 6 . 0 35 . 0 ) ng / ml ( P less than 0 . 02 ) over the same period . 4 . ^^^ Infusion of Intralipid in the presence of hyperinsulinaemia with either euglycemia or hyperglycaemia was associated with a similar fall in concentrations of plasminogen activator inhibitor 1 over the study period . 5 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 , the natural inhibitor of t PA , also has Arg and Ala residues at positions P 1 and P 2 . ^^^ In a purified system , alpha 1 antitrypsin Ala 357 Arg358 was 150 fold less efficient against C1s than C 1 inhibitor and 27 , 000 fold less efficient against t PA than plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have been interested by hyperinsulinemia , which is observed in obesity , impaired glucose tolerance , type 2 diabetes , and hypertriglyceridemia , and we have shown a very strong correlation between plasma insulin , body mass index , triglyceride levels , and one of the main inhibitors of the fibrinolytic system , plasminogen activator inhibitor 1 . ^^^ Partial correlation analysis showed that only the correlation between insulin and plasminogen activator inhibitor 1 was independent . ^^^ Therefore a high plasma insulin level could be responsible for elevated levels of plasminogen activator inhibitor 1 , which by inducing an hypofibrinolysis , could play a role in the deposition of fibrin and the development of atherothrombosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Studies of recombinant plasminogen activator inhibitor 1 in rabbits . ^^^ Pharmacokinetics and evidence for reactivation of latent plasminogen activator inhibitor 1 in vivo . ^^^ The pharmacokinetics of human recombinant plasminogen activator inhibitor 1 ( rPAI 1 ) was studied in rabbits . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Studies on plasminogen activator inhibitor 1 levels in human breast cancer . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To evaluate fibrinolytic activity , we measured plasma concentrations of tissue type plasminogen activator , plasminogen activator inhibitor 1 , and cross linked fibrin degradation products . ^^^ Plasminogen activator inhibitor 1 activity was elevated in 19 of the 27 patients in whom it was measured , potentially limiting the fibrinolytic response . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Resting and postvenous occlusion tissue type plasminogen activator ( t PA ) activity , resting t PA antigen , and resting plasminogen activator inhibitor 1 ( PAI 1 ) activity were measured in the morning and evening in 33 healthy men ( mean age , 31 years ) and in 15 patients ( mean age , 57 years ) with previous myocardial infarction or unstable angina . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To investigate the effects of aVP on components of the fibrinolytic pathway and on thrombin generation , 9 healthy volunteers were infused with saline for 30 min followed by aVP for 1 hour and blood samples taken every 30 min for measurement of aVP , ECLT , tissue type plasminogen activator ( t PA ) , t PA inhibition ( tPA 1 ) , plasminogen activator inhibitor 1 ( PAI 1 Ag ) , activated partial thromboplastin time ( APTT ) , fibrinopeptide A ( FPA ) , fibrinopeptide B 15 42 ( FPB beta 15 42 ) and cross linked fibrin breakdown products ( XL FDP ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
PMA also induces secretion of the two inhibitors of plasminogen activator : plasminogen activator inhibitor 1 ( PAI 1 ) and plasminogen activator inhibitor 2 ( PAI 2 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Messenger RNA for tissue plasminogen activator , plasminogen activator inhibitor 1 , urokinase , and thrombomodulin were expressed at higher levels in the ATCC cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Although LiCl restored synthesis of almost all host cell proteins , [ 35S ] methionine incorporation was most pronounced in thrombospondin and plasminogen activator inhibitor 1 and least in fibronectin and type 4 collagen . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Immunocytochemistry indicated that osteoblasts also constitutively produce plasminogen activator inhibitor 1 . ^^^ These findings provide evidence for the involvement of a plasminogen plasmin latent metalloproteinase activation cascade in type 1 collagen degradation by osteoblasts , and for its regulation by TIMP and plasminogen activator inhibitor 1 . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In contrast , squamous cell carcinoma derived cell lines secreted plasminogen activator only after treatment with the phorbol ester 12 O tetradecanoylphorbol 13 acetate ; enhanced levels of u PA , t PA , and plasminogen activator inhibitor 1 mRNAs could then be demonstrated . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 was variably detected and low levels of plasminogen activator inhibitor 2 were found in two ARDS BAL samples , but plasminogen activator inhibitor 2 was otherwise undetectable . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The mutant proteins were assayed for their ability to hydrolyze artificial and natural substrates in the presence and absence of fibrin , to bind to lysine Sepharose and to be inhibited by plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Relationships between plasma insulin triglyceride , body mass index , and plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma determination of plasminogen activator inhibitor 1 antigen must be performed in blood collected on antiplatelet / anticoagulant mixture . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 and plasminogen activator inhibitor 2 in various disease states . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The increase in plasminogen activator inhibitor activity found in the patients was partially inhibited by antiserum against plasminogen activator inhibitor 1 in vitro . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Associations between plasminogen activator inhibitor 1 and insulin , intact and 32 , 33 split proinsulin hypertriglyceridemia , and insulin resistance have been reported , but a unifying hypothesis explaining these links remains elusive . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Localization of a vitronectin binding region of plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Urokinase binding and catabolism by Hep G 2 cells is plasminogen activator inhibitor 1 dependent , analogous to interactions of tissue type plasminogen activator with these cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The profiles of the coagulation and fibrinolytic systems were monitored by measuring several parameters , including plasma levels of thrombin antithrombin 3 complex , antithrombin 3 , plasmin alpha 2 plasmin inhibitor complex , fibrin degradation product D dimer , tissue type plasminogen activator , and plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma thrombomodulin , tissue type plasminogen activator , and plasminogen activator inhibitor 1 levels were increased in all RCFS patients , suggesting that RCFS , whether MMC induced , or due to TTP or DIC , might be associated with vascular endothelial cell injury . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Levels of plasminogen activator inhibitor 1 , tissue type plasminogen activator , and von Willebrand factor antigens were also significantly increased in patients with PE . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : Secreted and cell associated levels of urokinase and plasminogen activator inhibitor 1 were measured in colonic crypt cells within 24 hours of isolation from macroscopically normal mucosa of normal or cancer bearing colons . ^^^ Butyrate also stimulated plasminogen activator inhibitor 1 secretion by 25 % + / 7 % ( P = 0 . 013 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The main components of the murine plasma fibrinolytic system , including fibrinogen , plasminogen , alpha 2 antiplasmin , tissue type plasminogen activator and plasminogen activator inhibitor 1 , were purified to homogeneity and their interactions were quantitated and compared with those of the human counterparts . ^^^ Murine and human plasmin were very rapidly inhibited by autologous and heterologous alpha 2 antiplasmin ( second order inhibition rate constants , k 1 , app , of 2 . 1 2 . 3 10 10 ( 7 ) M 1 s 1 ) and murine and human tissue type plasminogen activator were very rapidly inhibited by autologous or heterologous plasminogen activator inhibitor 1 ( k 1 , app of 1 . 8 4 . 9 10 10 ( 7 ) M 1 s 1 ) . ^^^ Two chain murine tissue type plasminogen activator ( added at a concentration of 1 microgram / ml ) was inhibited in normal or plasminogen activator inhibitor 1 deficient murine plasma with half lives of 6 . 5 min and 4 . 2 min , respectively , as compared to 80 min for human tissue type plasminogen activator , suggesting that murine plasma contains proteinase inhibitors other than plasminogen activator inhibitor 1 which efficiently inhibit autologous tissue type plasminogen activator . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Transcriptional regulation of plasminogen activator inhibitor 1 expression in human synovial fibroblasts by prostaglandin E 2 : mediation by protein kinase A and role of interleukin 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Platelet reactivity and plasma concentrations of fibrinogen , alpha 2 antiplasmin , plasminogen , thromboxane beta 2 , plasminogen activator inhibitor 1 , tissue plasminogen activator and neuroendocrine hormones ( cortisol , epinephrine and norepinephrine ) were measured at 8 : 00 a . m . , 10 : 00 a . m . , 4 : 00 p . m . and 8 : 00 a . m . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
LRP is a multifunctional receptor that binds and rapidly internalizes at least seven ligands : apolipoprotein E , activated alpha 2 macroglobulin , tissue and urokinase type plasminogen activators , plasminogen activator inhibitor 1 , lipoprotein lipase , and lactoferrin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 was higher than normal before transplantation ( 21 . 0 compared with 7 . 4 U / ml ) and increased further on the first day after operation ( 37 . 5 U / ml ; P < 0 . 05 versus pre transplantation ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Finally , LIF decreased the proteolytic activity of BAE and BME cells and increased their expression of plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Apolipoproteins A 1 and B also remained unchanged , along with plasma concentrations of fibrinogen and plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Direct and reverse zymography indicated that this reduction resulted from two simultaneous events , a pronounced decrease in tissue type plasminogen activator activity and an induction of plasminogen activator inhibitor 1 . ^^^ Northern hybridization analysis indicated a 30 fold increase of the steady state level of plasminogen activator inhibitor 1 mRNA following treatment with each of the two cytokines . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Role of cytoskeleton rearrangement and matrix bound plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Cytokines and plasminogen activator inhibitor 1 in posttrauma disseminated intravascular coagulation : relationship to multiple organ dysfunction syndrome . ^^^ OBJECTIVES : a ) To investigate the relationships between tumor necrosis factor alpha ( TNF alpha ) , interleukin 1 beta ( IL 1 beta ) , plasminogen activator inhibitor 1 , and disseminated intravascular coagulation ( DIC ) ; b ) to determine the influence of DIC on the mortality rate , adult respiratory distress syndrome ( ARDS ) , and multiple organ dysfunction syndrome ; and c ) to find a useful prognostic index for outcome . ^^^ MEASUREMENTS AND MAIN RESULTS : TNF alpha , IL 1 beta , plasminogen activator inhibitor 1 activity , and plasminogen activator inhibitor 1 antigen concentration were measured on the day of the injury , and on days 1 , 3 , and 5 after admission . ^^^ DIC patients were classified into subgroups of survivors and nonsurvivors , and the changes in plasminogen activator inhibitor 1 between subgroups were studied . ^^^ Plasminogen activator inhibitor 1 activity and plasminogen activator inhibitor 1 antigen concentrations in the DIC patients , especially those values in the nonsurvivors , continued to be markedly high up to day 5 of admission . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
RESULTS : The levels of endothelium derived markers ( thrombomodulin , tissue plasminogen activator plasminogen activator inhibitor 1 complex , active plasminogen activator inhibitor 1 and tissue factor pathway inhibitor ) did not differ between the subjects with high and those with low factor 7 activity . ^^^ The coagulation and lipid profiles of the group with vascular disease were closer to those of the high factor 7 group than to those of the low factor 7 group ; the same was true of elevated active plasminogen activator inhibitor 1 levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Considerable indirect evidence and more limited direct evidence suggests that increases in certain prognostically significant hemostatic variables notably plasma fibrinogen , factor 7 coagulant activity , and plasminogen activator inhibitor 1 levels may be concomitants of Syndrome 10 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We determined prothrombin time , activated partial thromboplastin time , clotting factor 8 activity , tissue plasminogen activator activity , tissue plasminogen activator inhibitor 1 , cross linked fibrin degradation product , and thrombin antithrombin 3 complexes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator and plasminogen activator inhibitor 1 release during experimental endotoxaemia in chimpanzees : effect of interventions in the cytokine and coagulation cascades . 1 . ^^^ In the present study we have delineated in detail the fibrinolytic response to a bolus injection of endotoxin in non human primates and analysed the contribution of cytokines and thrombin generation to the endotoxin induced release of tissue type plasminogen activator and plasminogen activator inhibitor 1 . ^^^ Plasminogen activator inhibitor 1 levels remained constant for the first 2 h , after which time a steep increase was observed . ^^^ Plasminogen activator activity and plasmin generation decreased simultaneously with the rise in plasminogen activator inhibitor 1 levels . ^^^ Fibrinolytic activity remained suppressed during the remainder of the study owing to sustained increased levels of plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The five high proteinases producers hardly secreted the corresponding inhibitors , such as tissue inhibitor of metalloproteinases ( TIMP ) 1 , 2 or plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
TS 1 expression resulted in a > 100 fold decrease in net fibrinolytic ( urokinase type plasminogen activator , uPA ) activity due to more plasminogen activator inhibitor 1 and less uPA secretion . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator activity during decidualization of human endometrial stromal cells is regulated by plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The assay used to assess the activity of TGF beta is based on cells transfected with a plasminogen activator inhibitor 1 promoter luciferase construct . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
There were , however , no significant differences between other proposed components of the insulin resistance syndrome ( blood pressure , glucose tolerance , proportion of central body fat , serum uric acid concentration , and plasminogen activator inhibitor 1 activity ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Engineering of plasminogen activator inhibitor 1 to reduce the rate of latency transition . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The cultured cells produced alpha 1 antitrypsin ( alpha 1 AT ) and plasminogen activator inhibitor 1 ( PAl 1 ) into the conditioned medium . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
There was no difference in body mass index ; fasting blood glucose ; systolic or diastolic blood pressure ; total , HDL , or LDL cholesterol ; triglycerides ; plasminogen activator inhibitor 1 ; or sodium lithium countertransport activity between consistently normoalbuminuric and persistently microalbuminuric subjects . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
RESULTS : Amniotic fluid contained high plasminogen activator inhibitor 1 concentrations but had low activity . ^^^ Strong staining for plasminogen activator inhibitor 1 and vitronectin was observed in chorionic trophoblasts and moderate staining in decidual connective tissue . ^^^ Although prominent staining of plasminogen activators and plasminogen were observed in the amniotic epithelium , virtually no plasminogen activator inhibitor 1 , plasminogen activator inhibitor 2 , or alpha 2 plasmin inhibitor staining was detected . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In addition , the synthesis and secretion of some proteinase inhibitors ( alpha 1 proteinase inhibitor , alpha 1 antichymotrypsin , C 1 inactivator , plasminogen activator inhibitor 1 , inter alpha trypsin inhibitor and pre alpha inhibitor ) was evaluated by incorporation of labelled methionine and fluorography . ^^^ Retinoic acid preferentially increased synthesis of alpha 1 antichymotrypsin , ceruloplasmin and plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In addition to rhoG , a new member of the ras homolog gene family ( Vincent et al . , 1992 ) , cDNA sequencing indicated that six of them correspond to cytoskeletal proteins ( alpha tubulin , vascular alpha actin and skeletal gamma actin ) , extracellular matrix protein ( thrombospondin ) , secreted protease ( plasminogen activator inhibitor 1 ) and energy linked transporter ( mitochondrial proton / phosphate symporter ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In both PC 3 and PC 3U cells , TGF beta 1 was found to stimulate the induction of fibronectin and plasminogen activator inhibitor 1 and the expression of junB mRNA , and PMA did not affect these responses . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Biological effects of disruption of the tissue type plasminogen activator , urokinase type plasminogen activator , and plasminogen activator inhibitor 1 genes in mice . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Other factors associated with the IRS that may enhance cardiovascular disease risk are plasminogen activator inhibitor 1 and small , dense low density lipoprotein particles . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
PCR based production of a ribozyme to plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Transfected BAECs exhibit increased responsiveness to TGF beta 2 by several different criteria including an increase in plasminogen activator inhibitor 1 protein and inhibition of migration and proliferation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Furthermore , we showed that human umbilical vein endothelial cells grown on polytetrafluoroethylene or polyurethane released more plasminogen activator inhibitor 1 and tissue type plasminogen activator into the conditioned media than did human umbilical vein endothelial cells grown on tissue culture polystyrene . ^^^ Human umbilical vein endothelial cells cultured on polytetrafluoroethylene also deposited more plasminogen activator inhibitor 1 into the extracellular matrix than did control cells grown on tissue culture polystyrene . ^^^ Our results give evidence that human umbilical vein endothelial cells grown on two biomaterials used to construct vascular grafts , namely polytetrafluoroethylene and polyurethane , produce tissue type plasminogen activator as well as plasminogen activator inhibitor 1 , two major components of the fibrinolytic system also expressed by endothelial cells in vivo . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The R value was high for beta thromboglobulin and tissue plasminogen activator : 0 . 83 and 0 . 81 , respectively ; and intermediate for D dimer and plasminogen activator inhibitor 1 : 0 . 73 and 0 . 72 , respectively . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The cells also produce plasminogen activator inhibitor 1 and urokinase plasminogen activator receptor . ^^^ Inhibition of plasminogen activation occurred with plasminogen activator inhibitor 1 , anti catalytic anti tissue plasminogen activator antibody , epsilon aminocaproic acid , which inhibits the binding of plasminogen through its lysine binding sites , and amiloride , which specifically inhibits urokinase . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Serum levels of interleukin 6 , and plasma levels of fibrinogen , von Willebrand factor antigen , tissue type plasminogen activator antigen , and plasminogen activator inhibitor 1 were determined for up to 48 h postoperatively . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The two endothelial cell types displayed functional heterogeneity in respect to bradykinin degradation and plasminogen activator inhibitor 1 activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The regulation of extracellular proteolytic activity by EC RF 24 was established by measuring both the induction of functional tissue factor ( promotion of Factor Xa generation ) and the functional deposition of plasminogen activator inhibitor 1 in the subendothelial matrix ( SDS resistant complex formation with thrombin ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Less known are hemostatic changes induced by exercise training programs : a few data are available on the effects on platelets and coagulation , whereas studies performed on fibrinolysis show a decrease in plasminogen activator inhibitor 1 levels at rest and an increase in fibrinolytic capacity after training . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Complexes of both types of plasminogen activators with plasminogen activator inhibitor 1 were detected in the culture medium of subclonal lines . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Thrombi protect themselves from lysis by incorporating inhibitors ( plasminogen activator inhibitor 1 and alpha 2 antiplasmin ) in their structure . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Differences in plasminogen activator inhibitor 1 activity between blacks and whites may be diet related . ^^^ The plasminogen activator inhibitor 1 activity was significantly lower ( p < 0 . 0001 ) in the Vendas than in the whites . ^^^ It is concluded that diet may be an important determinant of plasminogen activator inhibitor 1 activity . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In addition to higher maternal plasma concentrations of cellular fibronectin , we found higher levels of von Willebrand factor , tissue plasminogen activator , and plasminogen activator inhibitor 1 in maternal plasma , providing biochemical corroboration of endothelial dysfunction in severe preeclampsia . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 activity decreased during rt PA infusion and thereafter increased in all dogs , but less so in dogs given lys plasminogen ( p < 0 . 05 vs . those given saline solution before rt PA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Requirements for transforming growth factor beta regulation of the pro alpha 2 ( 1 ) collagen and plasminogen activator inhibitor 1 promoters . ^^^ Similar results were obtained with a plasminogen activator inhibitor 1 promoter , previously shown to be activated by TGF beta through AP 1 elements . ^^^ We conclude that TGF beta activates the alpha 2 ( 1 ) collagen and plasminogen activator inhibitor 1 promoters in NIH 3T3 cells through junB and the type 1 TGF beta receptor kinase domain . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
While the cleaved state can be achieved in all inhibitory serpins only plasminogen activator inhibitor 1 and , more recently , antithrombin have been shown to adopt the latent conformation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Levels were determined in maternal and cord plasma of tissue type plasminogen activator antigen and activity , plasminogen activator inhibitor 1 antigen , plasminogen activator inhibitor activity , and plasminogen activator inhibitor 2 antigen . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Vascular regulation of plasminogen activator inhibitor 1 activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue plasminogen activator antigen and plasminogen activator inhibitor 1 decreased simultaneously . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Gene regulation of interleukin 1 beta , interleukin 1 receptor type 1 , and plasminogen activator inhibitor 1 and 2 in human granulosa luteal cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A cause was identified in 61 cases ( 50 . 8 % ) : cancer ( n = 24 , 17 known , 7 previously unknown ) , dyscrasia ( n = 17 , protein S or C deficiency ( 5 ) , increased plasminogen activator inhibitor 1 ( 8 ) , circulating anticoagulants ( 3 ) , hypofibrinogen ( 1 ) , idiopathic varicose veins ( n = 7 ) , pregnancy ( n = 5 ) , oral contraceptives ( n = 4 ) and other causes ( n = 4 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Effects of lovastatin therapy on plasminogen activator inhibitor 1 antigen levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Local production of plasminogen activator inhibitor 1 in carcinomatous pleuritis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Endothelial cell secretory compounds like von Willebrand factor , tissue plasminogen activator , and plasminogen activator inhibitor 1 were constitutively released to both sides . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Intraperitoneal insulin administration does not modify plasminogen activator inhibitor 1 levels in IDDM patients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Gp 330 is expressed by a number of specialized epithelia , including renal proximal tubules , where it can mediate endocytosis of ligands such as complexes of urokinase and the serpin , plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
It is 20 % as potent as native TGF beta 1 in the induction of plasminogen activator inhibitor 1 promoter expression in mink lung epithelial cells ( Mv1Lu ) , although it is less than 1 % as potent as native TGF beta 1 in inhibition of growth in the same cell line . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
At the same time epidemiological data are pointing at the possible role of fibrinogen , factor 7 and plasminogen activator inhibitor 1 as risk factors for ischemic heart disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Polymorphisms of the plasminogen activator inhibitor 1 gene in type 1 and type 2 diabetes , and in patients with diabetic retinopathy . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Anti tPA antibody or plasminogen activator inhibitor 1 prolonged ECLT in the absence of Ca2+ , whereas they had no effect on ECLT shortened by Ca2+ . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 expression in human liver and healthy or atherosclerotic vessel walls . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Comparative thrombolytic properties of tissue type plasminogen activator and of a plasminogen activator inhibitor 1 resistant glycosylation variant , in a combined arterial and venous thrombosis model in the dog . rt PA K , a variant of recombinant tissue type plasminogen activator ( rt PA ) with substitution of amino acids 296 to 299 with alanine ( KHRR 296 299AAAA ) has increased fibrin specificity and reduced sensitivity to plasminogen activator inhibitor 1 ; rt PA T , with threonine 103 replaced by asparagine has an additional glycosylation site and a reduced clearance ; and rt PA N , with asparagine 117 mutagenized to glutamine lacks the high mannose carbohydrate side chain . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Left ventricular mass index and minimal forearm vascular resistances were comparable in patients with hypertension and higher than in controls ; total and low density lipoprotein cholesterol , triglycerides , lipoprotein a , Factor 7 , and plasminogen activator inhibitor 1 did not differ . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
When transfected into a mutant mink lung epithelial cell line that lacks functional T beta R 2 , T beta R 2 cDNA , but not T beta R 2 . 1 cDNA , restored the responsiveness to TGF beta 1 with regard to transcriptional activation of plasminogen activator inhibitor 1 gene promoter and 12 O tetradecanoylphorbol 13 acetate responsive elements . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In addition , embryonic fibroblasts lacking LRP are unable to bind , internalize and degrade methylamine activated alpha 2 macroglobulin and complexes of urokinase with plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Among coagulation factors , only thrombin antithrombin ( TAT ) complexes were twice as high in embolic as in nonembolic patients ( 14 . 0 + / 13 . 6 vs . 7 . 0 + / 4 . 2 ng / ml ; p < 0 . 02 ) , while there was no statistically significant difference between embolic and nonembolic patients for activated partial thromboplastin time , prothrombin time , antithrombin 3 , protein C , fibrinogen , plasminogen , alpha 2 plasmin inhibitor , and plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The specimens were stained with antibodies against fibrinogen , fibrin , plasminogen activator inhibitor 1 , factor 8 related antigen , and collagen type 4 . ^^^ The finding of plasminogen activator inhibitor 1 in the pericapillary cuff in the patient with the most severe signs of venous hypertension may indicate that breakdown of this fibrin cuff is impaired . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Measurements of plasminogen activity , alpha 2 antiplasmin activity , tissue plasminogen activator , and plasminogen activator inhibitor 1 , representing variables of fibrinolysis , were normal and constant during the study . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : We determined fibrinogen , antithrombin 3 , thrombin antithrombin 3 complex , tissue plasminogen activator antigen , plasminogen activator inhibitor 1 , plasmin alpha 2 plasmin inhibitor complex , and D dimer in plasma from 153 poststroke patients in the chronic phase ( ie , 33 patients not receiving antiplatelet medication , 78 patients receiving 200 mg / d ticlopidine , and 42 patients receiving 40 mg / d aspirin ) , and compared the results in control subjects and among the treatment groups . ^^^ The plasminogen activator inhibitor 1 levels were significantly elevated in patients not receiving antiplatelet medication compared with control subjects ( P < . 01 ) , whereas they were in the normal range and significantly lower in patients receiving ticlopidine or aspirin than in patients not receiving antiplatelet medication ( P < . 01 ) . ^^^ The plasminogen activator inhibitor 1 levels were significantly lower in patients whose platelet aggregation was inhibited by antiplatelet medication than in patients with uninhibited platelet aggregability ( P < . 05 ) . ^^^ CONCLUSIONS : These findings suggest that coagulation fibrinolysis markers are mildly increased in poststroke patients in the chronic phase and that antiplatelet medication is effective in reducing the elevated plasminogen activator inhibitor 1 levels . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Measurements of plasminogen , tissue plasminogen activator , plasminogen activator inhibitor 1 , and alpha 2 antiplasmin plasmin complex provide information on fibrinolytic turnover . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The effects of hyperthermia on potentially prothrombotic endothelial function were investigated by measuring levels of von Willebrand factor , thrombospondin , tissue plasminogen activator and plasminogen activator inhibitor 1 secreted by unstimulated human umbilical vein endothelial cells cultured at 37 degrees C , 39 degrees C , 41 degrees C and 43 degrees C for 24 h . ^^^ In contrast , elevated temperatures markedly increased plasminogen activator inhibitor 1 while decreasing t PA secretion , though after prolonged exposure to 43 degrees C the levels of both returned to control values . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Secretion of urokinase and plasminogen activator inhibitor 1 by normal colonic epithelium in vitro . ^^^ The contents of urokinase and one of its specific inhibitors , plasminogen activator inhibitor 1 , were measured in culture supernatant and cell homogenates of isolated human colonic crypt cells . ^^^ Northern blot analysis showed that messenger ribonucleic acid specific for urokinase and plasminogen activator inhibitor 1 was present in colonic crypt cells and that expression over 18 hours of culture was increased 12 fold for urokinase type plasminogen activator and two to fourfold for the inhibitor compared with values found in autologous freshly isolated cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The inactive molecule has a totally incorporated loop as in latent plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Relationship between plasma plasminogen activator inhibitor 1 activity and VLDL triglyceride concentration , insulin levels and insulin sensitivity : studies in randomly selected normo and hypertriglyceridaemic men . ^^^ Impaired fibrinolytic function secondary to elevated plasma plasminogen activator inhibitor 1 activity , hypertriglyceridaemia and hyperinsulinaemia are frequent findings in patients with coronary heart disease . ^^^ It has been debated whether VLDL or insulin is the major regulator of plasma plasminogen activator inhibitor 1 activity . ^^^ This study examines the relationships between plasma plasminogen activator inhibitor 1 activity and VLDL triglyceride concentration , fasting and post oral glucose load insulin levels and insulin sensitivity , as estimated by the minimal model method . ^^^ Plasma plasminogen activator inhibitor 1 activity was higher in the hypertriglyceridaemic than in the normotriglyceridaemic group ( 21 + / 14 vs 10 + / 8 mU / l ; p < 0 . 01 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The formed APC in the presence of its co factor PS , downregulates the coagulation cascade by proteolytic inactivation of the procoagulant cofactors Va and VIIIa , and also enhances the fibrinolysis system by inhibition of plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In addition , expression of the steady state level of plasminogen activator inhibitor 1 and cyclooxygenase 2 was elevated in senescent populations of all HUVEC strains examined , whereas young populations exhibited a low level of expression for these genes regardless of the IL 1 alpha mRNA level . ^^^ Thus , we suggest that while mRNA levels of the IL 1 response genes for plasminogen activator inhibitor 1 and cyclooxygenase 2 are appropriate markers for HUVEC senescence , HUVEC strain specific post transcriptional mechanisms may exist to regulate the function of IL 1 alpha as a modifier of HUVEC senescence in vitro . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue plasminogen activator antigen measured after venous occlusion showed a significant reduction whilst plasminogen activator inhibitor 1 activity was 26 . 0 + / 9 . 8 IU ml 1 on oral treatment and 18 . 2 + / 4 . 7 IU ml 1 on insulin treatment ( NS ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Northern blot analysis revealed that both tPA and plasminogen activator inhibitor 1 messenger RNA levels were elevated at 60 to 120 minutes in well perfused tissues distant from the ischemic insult . ^^^ In addition , peripheral ischemia appears to stimulate both tPA and plasminogen activator inhibitor 1 gene expression in well perfused tissues at later time points , consistent with the existence of humoral mediators . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
MAIN OUTCOME MEASURES Comparisons of concentrations of tissue plasminogen activator , urokinase type plasminogen activator , tissue plasminogen activator inhibitor 1 , cross linked fibrin degradation products , von Willebrand factor , and thrombin antithrombin 3 complexes in patients and controls at admission ; same comparisons in patients with silent ischaemia at the start of an episode and 10 minutes later . ^^^ Tissue plasminogen activator inhibitor 1 concentrations were raised in patients with acute myocardial infarction ( 45 . 1 ( 15 ) ng / ml ) compared with volunteers ( 20 . 6 ( 16 ) ng / ml , p < 0 . 01 ) . ^^^ In patients with silent ischaemia tissue plasminogen activator inhibitor 1 concentrations were slightly but not significantly increased . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A systematic analysis revealed that most ALKs formed heteromeric complexes with the type 2 receptors for TGF beta and activin after overexpression in COS cells ; however , among the six ALKs , only ALK 5 was a functional TGF beta type 1 receptor for activation of plasminogen activator inhibitor 1 , and only ALK 2 and ALK 4 bound activin with high affinity . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The steady state mRNA levels of different osteogenic markers and their modulation by 17 beta estradiol in the murine osteogenic cell line MN 7 during proliferation and differentiation in vitro were examined . mRNA of collagen type 1 , osteopontin , bone morphogenetic protein 2 , plasminogen activator inhibitor 1 , alkaline phosphatase , and osteocalcin were isolated from MN 7 cultures grown for 7 , 11 , 14 , and 17 days . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
TRAP induced rapid morphological changes in HUVECs , with marked increase in the release of prostacyclin , endothelin , platelet activating factor , tissue type plasminogen activator , and plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue plasminogen activator , plasminogen activator inhibitor 1 , and fibrin as indexes of clinical course in cardiac allograft recipients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
No effect of metformin or metoprolol CR was seen on the glucose disposal rate , blood glucose , plasma insulin , triglycerides , high density lipoprotein cholesterol , lipoprotein ( a ) , uric acid or plasminogen activator inhibitor 1 activity or antigen . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
With regard to the initial stage of the fibrinolytic system , such as tissue type plasminogen activator and plasminogen activator inhibitor 1 , there was no difference between the groups . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
TNK tPA exhibits 80 fold higher resistance to plasminogen activator inhibitor 1 than tPA and 14 fold enhanced relative fibrin specificity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
RESULTS : Twenty five of the patients had some kind of aberration of specific hemostasis parameters ; seven patients had an increase in the activity of the plasminogen activator inhibitor 1 ( ie , a glycoprotein associated with diminished fibrinolysis ) compared with that in the control group ( P < . 05 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Testosterone correlated negatively with the risk factors fibrinogen , plasminogen activator inhibitor 1 , and insulin and positively with high density lipoprotein cholesterol . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fibrinolytic activity was determined by a balance between tissue plasminogen activator and plasminogen activator inhibitor 1 . ^^^ There was no significant difference between the two groups in the concentration of tissue plasminogen activator ( 34 ( 12 64 ) ng / ml in malignant ascites 5 29 ( 12 43 ) ng / ml in alcoholic ascites ) , but the concentration of plasminogen activator inhibitor 1 was significantly higher in malignant ascites ( 736 ( 213 1651 ) ng / ml ) than in alcohol ascites ( 29 ( 12 43 ) ng / ml ) ( p < 0 . 05 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
It is not clear whether loss of endogenous ovarian steroid production or the effects of the orally administered contraceptive steroids cause significant changes in hemostatic factors ( antithrombin 3 , protein S , protein C , plasminogen , tissue type plasminogen activator , plasminogen activator inhibitor 1 , histidine rich glycoprotein , and 7 , 8 , 10 , 12 coagulation factors ) during OC use . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Asn 17 Ras inhibited both TGF beta dependent and basal expression of inducible promoters ( skeletal alpha actin and plasminogen activator inhibitor 1 ) , with equivalent dose response relations . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Extracellular matrix markers of TGF beta 1 activity , a special isoform of fibronectin , tenascin , biglycan and plasminogen activator inhibitor 1 , were significantly elevated in kidneys undergoing fibrosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The transcriptional responses include elevated expression of fibronectin and plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Changing the P 1 ' residue Ser 355 > Met generated a reactive site like plasminogen activator inhibitor 1 and this protein inhibits all the proteinases essentially like wild type rPCI . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Putative profibrinolytic mechanisms include the release of urokinase type and tissue type plasminogen activators , decreases in plasminogen activator inhibitor 1 and 2 , and decreases in alpha 2 plasmin inhibitor . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 and atherothrombosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Transfection of the cloned cDNA into TGF beta type 1 receptor deficient cells restored TGF beta induced plasminogen activator inhibitor 1 production . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Regulation of plasminogen activator inhibitor 1 levels in human monocytes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue plasminogen activator activity was found at normal levels , whereas the level of its fast inhibitor , plasminogen activator inhibitor 1 , was greatly increased compared with that of controls ( 24 . 3 U / ml and 7 . 4 U / ml , respectively ) , indicating a shift toward inhibition of fibrinolysis in these patients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
No significant differences were found in blood lipids ( Lp ( a ) , serum cholesterol , low density lipoprotein and high density lipoprotein cholesterol and triglycerides ) , glycaemic control ( HbA1c ) and several haemostasis parameters ( factor 7 , 8 , fibrin monomer , thrombin antithrombin 3 , D dimer , tissue plasminogen activator antigen and plasminogen activator inhibitor 1 ) between the micro and normoalbuminuric subgroups . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Those with an abnormal coronary angiogram had lower tissue plasminogen activator levels , higher plasminogen activator inhibitor 1 levels and more android fat than did those with a normal angiogram ( p < 0 . 05 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In addition , GPI anchored tcu PA exhibited a modest resistance to plasminogen activator inhibitor 1 inactivation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 , Pefabloc TPA , diisopropyl fluorophosphate or alpha 1 anti trypsin inhibit the mitogenic effect of t PA for smooth muscle cells in a dose dependent manner , showing that it is dependent on the enzymatic activity . t PA activated phosphoinositide turnover in smooth muscle cells through a pertussis toxin insensitive pathway and stimulated proto oncogene c fos and c jun mRNA levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor levels rose significantly , but this activity was not due to plasminogen activator inhibitor 1 antigen , whose value significantly fell . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The level of host mRNA for fibronectin , thrombospondin , collagen type 4 , actin , and plasminogen activator inhibitor 1 were maintained in the presence of LiCl . mRNAs for viral proteins , ICP 4 and DNA polymerase were nearly undetectable when LiCl was added with the virus ( 0 time postinfection ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Although compensatory hyperinsulinaemia may prevent the development of NIDDM in insulin resistant individuals , there is substantial evidence that insulin resistance and / or hyperinsulinaemia is associated with higher plasma concentrations of triglyceride , uric acid and plasminogen activator inhibitor 1 and with lower HDL cholesterol concentrations . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In these fractions serum amyloid A 3 , lipocalin 24p3 , cathepsin B , and plasminogen activator inhibitor 1 were characterized as LPS induced proteins secreted by macrophages . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue type plasminogen activator , urokinase type plasminogen activator , plasminogen activator inhibitor 1 , and plasminogen activator inhibitor 2 were also measured by means of enzyme linked immunosorbent assays . ^^^ However , neither plasminogen activator inhibitor 1 nor plasminogen activator inhibitor 2 was detected . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
P A 1 suppressed protein C activation , enhanced release of plasminogen activator inhibitor 1 , but had no effect on tissue plasminogen activator release . ^^^ Plasminogen activator inhibitor 1 released by P A 1 was functional as evidenced by the capacity to form a covalent complex with 125I urokinase . ^^^ Inactive albumin ( isolated during the same purification procedure as P A 1 , but without tissue factor inducing activity ) did not suppress protein C activation or increase plasminogen activator inhibitor 1 release . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Recombinant plasminogen activator inhibitor 1 protects platelets against the inhibitory effects of plasmin . ^^^ The goal of this study was to assess whether biologically active recombinant plasminogen activator inhibitor 1 ( rPAI 1 ) , could antagonize the inhibitory effects of plasmin on GPIb . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma fibrinogen was significantly higher ( 2 . 8 versus 2 . 3 g / l , P < 0 . 005 ) in patients than in controls , but there were no significant differences in the median plasma concentrations of euglobulin clot lysis time , fibrin plate lysis area , plasminogen , alpha 2 antiplasmin , tissue plasminogen activator activity , and antigen , tissue plasminogen activator inhibition and plasminogen activator inhibitor 1 antigen level . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The degradation rates of beta actin , plasminogen activator inhibitor 1 , and epidermal growth factor receptor mRNAs were examined in the presence of actinomycin D . beta Actin mRNA was found to be specifically destabilized in TNF alpha treated HOME cells , while other mRNA species were not . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The type 1 receptors are responsible for effects on extracellular matrix , such as the induction of fibronectin and plasminogen activator inhibitor 1 , and for increased JunB expression . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
As modulators of fibrinolytic activity , these cells synthesize and secrete tissue plasminogen activator ( t PA ) as well as its physiologic inhibitor , plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Dynamic structural and functional relationships in recombinant plasminogen activator inhibitor 1 ( rPAI 1 ) . ^^^ The conformational characteristics of active , latent , and denatured recombinant plasminogen activator inhibitor 1 ( rPAI 1 ) were compared using UV spectroscopy , spectrofluorimetry and circular dichroism ( CD ) techniques . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The relationship between plasminogen activator inhibitor 1 and insulin resistance in newly diagnosed type 2 diabetes mellitus . ^^^ It is not clear whether elevated levels of the fibrinolytic inhibitor , plasminogen activator inhibitor 1 ( PAl 1 ) in Type 2 diabetes mellitus are the result of obesity or coexistent atherosclerosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Sample preparation for plasma measurement of plasminogen activator inhibitor 1 antigen in large population studies . ^^^ Plasminogen activator inhibitor 1 is important in regulating fibrinolysis and may be an important cardiovascular risk factor . ^^^ Because of this , there is increased interest in performing plasminogen activator inhibitor 1 assays in large epidemiologic studies . ^^^ Our aim in this study was to determine the simplest blood collection methods that yield accurate results with our plasminogen activator inhibitor 1 antigen assay . ^^^ Our results indicate that the following issues are important : ( 1 ) since there is a large circadian variation in plasminogen activator inhibitor 1 plasma levels , a target time frame must be established ; ( 2 ) commercially available citrate collection tubes are adequate , if sample processing is rapid ; ( 3 ) careful venipuncture is necessary , with freely flowing collection ; hemolysis must be avoided ; and ( 4 ) centrifugation of at least 30 , 000 g . min is required to avoid platelet contamination . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma concentrations of prothrombin fragments F 1 + F 2 , fibrinogen , plasminogen , and plasminogen activator inhibitor 1 were unaffected . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In a previous study , homocysteine decreased cell surface expression of the surface transmembrane glycoprotein thrombomodulin without decreasing secretion of another endothelial cell protein , plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In cases of severe infection with DIC , impaired fibrinolysis due to abnormal elevation of plasminogen activator inhibitor 1 is frequently seen . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The complexes of HUK and LUK with plasminogen activator inhibitor 1 or 2 could compete in either radioimmunoassay , with different and diminished efficiencies . ^^^ By using a combination of radioimmunoassay and zymography , we found that human plasma contains mostly HUK plasminogen activator inhibitor 1 complexes , a small amount of single chain urokinase or HUK , and no LUK or LUK inhibitor complexes . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fibrinolytic activity is impaired in the elderly , probably due to an increase in plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Deficiency of plasma plasminogen activator inhibitor 1 results in hyperfibrinolytic bleeding . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Modulation of plasminogen activator inhibitor 1 and urokinase in retinal pigmented epithelial cells . ^^^ To examine the effect of several agents that either stimulate or inhibit neovascularization on plasminogen activator inhibitor 1 and urokinase in retinal pigmented epithelial cells and vascular endothelial cells . ^^^ Data indicate that messenger RNA levels for plasminogen activator inhibitor 1 are modulated in similar fashion in both cells types , being increased by incubation with transforming growth factor beta , dexamethasone , tumor necrosis factor , phorbol myristate acetate , and thrombin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We studied the effect of a single infusion of this lipid emulsion ( 500 mL of a 10 % emulsion , give over 5 to 6 hours ) on the plasma levels of tissue plasminogen activator and plasminogen activator inhibitor 1 antigens in 12 patients with various diseases . ^^^ Plasminogen activator inhibitor 1 was similar in control and treated patients at all intervals . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Predictive value for thrombotic disease of plasminogen activator inhibitor 1 plasma levels . ^^^ Plasminogen activator inhibitor 1 plays a major role in the fibrinolytic system as the main physiological inhibitor of both tissue type and urinary type plasminogen activators . ^^^ Moreover , high plasma inhibitor concentrations have been observed in different disease states , but it must be stressed that plasminogen activator inhibitor 1 behaves as an acute phase reactant and measurement of plasma levels is not significant in the acute phase of the disease . ^^^ On the basis of available studies , the predictive value is not clear for venous thrombosis , whereas plasminogen activator inhibitor 1 levels can predict some coronary events , at least in subgroups of young patients with a first myocardial infarction . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In order to find out the hemostatic risk factors of coronary artery disease in the Chinese , antithrombin 3 concentration , factor 7 and fibrinogen assays , plasminogen activator inhibitor 1 antigen and platelet count were determined in 51 healthy controls ( mean age 63 . 5 years , S . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Changes of the plasma levels of tissue plasminogen activator and plasminogen activator inhibitor 1 in cerebral infarction induced by the venous occlusion ] . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To investigate sex differences in coagulation and fibrinolysis in NIDDM , we measured levels of fibrinogen , factor 7 : C , von Willebrand factor , plasminogen activator inhibitor 1 , and tissue plasminogen activator in 213 NIDDM subjects ( 124 men and 89 women ) who were not receiving insulin therapy . ^^^ The women had higher levels of factor 7 : C ( 144 % versus 120 . 5 % in men , P < . 0005 ) and plasminogen activator inhibitor 1 activity ( 25 . 6 versus 17 . 0 U / mL ) , and these differences remained significant when account was taken of the higher body mass index ( 29 . 6 versus 28 . 0 kg / m2 , P = . 02 ) , glycosylated hemoglobin ( 7 . 2 % versus 6 . 8 % , P < . 05 ) , and cholesterol levels ( 6 . 3 versus 5 . 7 mmol / L , P < . 0005 ) in women than men . ^^^ These results suggest that elevated levels of plasminogen activator inhibitor 1 and factor 7 : C may contribute to the increased cardiovascular risk of NIDDM that is particularly marked in women . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Levels of factor VIIc associated with decreased tissue factor pathway inhibitor and increased plasminogen activator inhibitor 1 in dyslipidemias . ^^^ Tissue factor pathway inhibitor ( TFPI ) , a kunitztype inhibitor of the extrinsic coagulation pathway , factor 7 coagulant ( FVIIc ) , FVIIa , and the fibrinolytic factors plasminogen activator inhibitor 1 ( PA 1 1 ) and tissue plasminogen activator ( TPA ) have been studied in various hyperlipidemias . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Bleomycin induced pulmonary fibrosis in transgenic mice that either lack or overexpress the murine plasminogen activator inhibitor 1 gene . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activity and antigen , euglobulin fibrinolytic activity , tissue type plasminogen activator activity and antigen urokinase type plasminogen activator antigen , plasminogen activator inhibitor 1 activity and antigen , plasminogen activator inhibitor 2 antigen , tissue type plasminogen activator / plasminogen activator inhibitor complexes , alpha 2 antiplasmin , histidine rich glycoprotein , and fibrinogen / fibrin degradation products were measured in blood samples taken from the umbilical vein of 100 healthy full term newborns . ^^^ There was a significant reduction in plasminogen activity and antigen ( P < 0 . 0001 ) , plasminogen activator inhibitor 1 activity ( P < 0 . 05 ) , alpha 2 antiplasmin ( P < 0 . 0001 ) , and histidine rich glycoprotein ( P < 0 . 0001 ) , whereas plasminogen activator inhibitor 2 , tissue type plasminogen activator / plasminogen activator inhibitor complexes and fibrinogen / fibrin degradation products did not differ between groups . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Environmental and genetic factors in relation to elevated circulating levels of plasminogen activator inhibitor 1 in Caucasian patients with non insulin dependent diabetes mellitus . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
These include fibronectin , laminin , type 4 collagen , and plasminogen activator inhibitor 1 , along with additional unidentified proteins . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Additionally , the enzyme is not inhibited by plasminogen activator inhibitor 1 which is the primary physiological inhibitor of both urokinase and tissue type plasminogen activator . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Our results showed that endothelial cells incubated in vitro with retinoic acid increased the release of tissue plasminogen activator to the supernatant without concomitant secretion of plasminogen activator inhibitor 1 . ^^^ In patients treated with isotretinoin or etretinate these findings were confirmed , showing enhanced baseline tissue plasminogen activator concentrations in plasma in association with unchanged levels of plasminogen activator inhibitor 1 and von Willebrand factor . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Prognostic value of urokinase plasminogen activator and plasminogen activator inhibitor 1 in renal cell cancer . ^^^ In a prospective study urokinase and plasminogen activator inhibitor 1 content in renal cell cancer and benign renal tissue was correlated with the traditional factors of TNM staging and grading as well as ploidy and actual clinical outcome of the patients . ^^^ Urokinase and plasminogen activator inhibitor 1 from the tumor tissue and corresponding benign renal tissue were quantified from detergent extracted tissue samples ( 1 % triton 10 = 100 in TBS ) and measured with an enzyme linked immunosorbent assay . ^^^ Plasminogen activator inhibitor 1 significantly correlated with the prevalence of distant metastases ( log rank 5 . 17 , MO , 10 . 04 versus M 1 , 23 . 79 , p = 0 . 02 ) and the development of new metastases postoperatively ( MO , 10 . 85 versus M 1 , 27 . 36 , p = 0 . 001 ) . ^^^ A group of 41 patients were considered at high risk for relapse ( 6 ) based on plasminogen activator inhibitor 1 greater than 12 ng / mg . protein compared to 55 patients with plasminogen activator inhibitor 1 less than 12 ng / mg . protein with only 1 relapse during followup . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In addition , the plasma concentration of enhanced thrombin generation , D dimer formation and plasminogen activator inhibitor 1 decreased towards normal levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fibrinolytic proteins were similar in both groups , demonstrating a decrease in plasminogen activator inhibitor 1 activity at 8 and 24 h ( 196 % in the hormone group vs . 199 % in the placebo group ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Results of some in vivo studies suggest that both ionic and nonionic CM increase fibrinolytic activity , either by lowering plasma plasminogen activator inhibitor 1 levels , by releasing endogenous tissue plasminogen activator andor by altering the fibrin meshwork of thrombi . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The genes of ACHE , plasminogen activator inhibitor 1 ( PLANH 1 ) , CCAAT displacement protein ( CUTL 1 ) and Met proto oncogene ( MET ) were deleted in all cases . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The adhesion protein vitronectin is associated with extracellular matrices and serves as cofactor for plasminogen activator inhibitor 1 . ^^^ The 61 63 kDa vitronectin fragment was indistinguishable in its adhesive properties to intact vitronectin and bound active but not latent plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Sera obtained from VN deficient mice are completely deficient in `` serum spreading factor ' ' and plasminogen activator inhibitor 1 binding activities . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma levels of tissue type plasminogen activator ( TPA ) and plasminogen activator inhibitor 1 help identify subjects with a history of cerebral ischemic episodes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma concentrations of tissue type plasminogen activator antigen and activity as well as plasminogen activator inhibitor 1 antigen and activity were measured under resting conditions in 12 hypertensive ( 69 . 4 + / 1 . 4 years ) and 11 normotensive 65 . 2 + / 1 . 3 years ) older men . ^^^ There were no significant differences between the hypertensive and normotensive men in tissue type plasminogen antigen ( 7 . 3 + / 0 . 5 versus 6 . 1 + / 0 . 6 ng / mL ) and activity ( 1 . 8 + / 0 . 3 versus 1 . 7 + / 0 . 2 IU / mL ) or plasminogen activator inhibitor 1 antigen ( 14 . 1 + / 2 . 3 versus 10 . 8 + / 2 . 2 ng / mL ) and activity ( 17 . 4 + / 1 . 2 versus 17 . 5 + / 1 . 8 arbitrary units [ AU ] / mL ) levels . ^^^ In addition , the molar concentration ratio of active tissue type plasminogen activator to active plasminogen activator inhibitor 1 did not differ between the hypertensive ( 1 : 9 . 7 + / 2 . 3 ) mmol / L ) and normotensive ( 1 : 10 . 5 + / 2 . 2 mmol / L ) subjects , indicative of no impairment in fibrinolytic potential in either group . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
All three OCs increased plasminogen , fibrinogen , and D dimer levels and reduced plasminogen activator inhibitor 1 antigen levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BetaR IIb as well as betaR 2 stably expressed in betaR 2 deficient DR 26 cells acted as a functional receptor transducing signals from TGF beta for growth inhibition and the transcriptional activation of the plasminogen activator inhibitor 1 promoter . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Overproduction of TAB 1 enhanced activity of the plasminogen activator inhibitor 1 gene promoter , which is regulated by TGF beta , and increased the kinase activity of TAK 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Endotoxin caused large increases in plasminogen activator inhibitor 1 mRNA and modest increases in tissue factor mRNA in most tissues examined . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
After extraction plasminogen activator activity ( PAA ) was determined by using a chromogenic substrate assay in the presence or absence of inhibitory antibodies against tissue type plasminogen activator ( t PA ) , urokinase or plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The transcriptional activation by TGF beta of plasminogen activator inhibitor 1 and fibronectin was entirely suppressed . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Levels of fibrinogen , tissue factor pathway inhibitor ( TFPI ) , thrombin anti thrombin complex , and plasminogen activator inhibitor 1 in plasma increased significantly in the diabetic patients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
With a 2 h insulin infusion , serum norepinephrine , epinephrine , plasminogen activator inhibitor 1 , and intraplatelet Ca2+ decreased significantly , but 6 keto prostaglandin ( PG ) F 1 alpha and PGE 2 did not change . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Both cell types increase plasminogen activator inhibitor 1 production , switch actin phenotypes in response to TGF beta 1 , and produce similar levels of TGF beta activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : Plasminogen activator inhibitor 1 , the major serum protease inhibitor of fibrinolysis , increases steadily during pregnancy . ^^^ The study objective was to examine four hormones , namely , estradiol 17 beta , progesterone , prolactin , and hydrocortisone to determine their individual contributions in the production of tissue plasminogen activator antigen , plasminogen activator inhibitor 1 antigen , and plasminogen activator inhibitor 1 activity . ^^^ RESULTS : Of the four hormones evaluated , only hydrocortisone significantly increased plasminogen activator inhibitor 1 antigen and activity at both concentrations tested ( p < 0 . 001 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Increased lysis resistance of the platelet rich clots was demonstrated in polycythemia and essential thrombocythemia , ostensibly caused by the high plasma level of plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Northern blot analyses of RNA from the cultured cells demonstrated that the steady state levels of mRNA for uPA , but not for tPA and plasminogen activator inhibitor 1 , were decreased by indomethacin ; this decrease was reversed by prostaglandin E 2 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Recently , generation of mice with single or combined deficiencies of main components of the fibrinolytic system , including plasminogen , tissue type and urokinase type plasminogen activator , plasminogen activator inhibitor 1 , and the cellular receptor for urokinase type plasminogen activator has allowed the role of the fibrinolytic system in vivo to be established more conclusively . ^^^ Disruption of the plasminogen activator inhibitor 1 gene in mice induces a mild hyperfibrinolytic state and a greater resistance to venous thrombosis , but does not impair hemostasis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Increased expression of plasminogen activator inhibitor 1 in R . rickettsii infected endothelial cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In pre eclampsia , a fibrinolytic failure , resulting from an increase in plasma and placental concentrations of plasminogen activator inhibitor 1 , was observed . ^^^ The localized elevated concentrations of placenta plasminogen activator inhibitor 1 protein and mRNA observed in pre eclamptic patients would be expected to foster the deposition of fibrin and thus play a role in the complications associated with this disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In contrast , AON to mitogen activated protein kinase failed to inhibit Ang 2 stimulation of plasminogen activator inhibitor 1 mRNA levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
RESULTS : Relatives had higher plasma levels of plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The D D dimer and plasminogen activator inhibitor 1 showed no significant changes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Synthesis of another extracellular matrix protein , plasminogen activator inhibitor 1 , was stimulated by TGF beta 1 in both primary as well as metastatic tumors . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Immediately after operation , the ratio of thrombin antithrombin 3 complex to plasmin alpha 2 plasmin inhibitor complex was significantly greater and the ratio of tissue type plasminogen activator to plasminogen activator inhibitor 1 was significantly lower in patients who underwent hepatic resection than comparable ratios in patients who underwent colorectal resection . ^^^ In the murine model , fibrin like products with immunostaining of plasminogen activator inhibitor 1 were broadly deposited at the edge of the residual liver on postoperative day 5 , then disappeared by postoperative day 14 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Malignant tissue extracts had significantly higher levels of urokinase type plasminogen activator and plasminogen activator inhibitor 1 , but lower levels of tissue type plasminogen activator than normal mucosa . ^^^ Plasminogen activator inhibitor 1 alone was higher in advanced ( Dukes ' stages C + D ) than limited ( B ) tumors . ^^^ Plasma levels of plasminogen activator inhibitor 1 antigen were significantly increased in cancer patients compared with controls , but there were no differences in tissue type and urokinase type plasminogen activator , in plasminogen activator inhibitor 2 , and D dimer levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To test this hypothesis , we measured serum levels of HGF , lipoprotein ( a ) , plasminogen activator inhibitor 1 , tissue plasminogen activator , total cholesterol , and blood pressure in 41 normotensive and hypertensive subjects without liver , kidney , or lung damage . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Blood samples for platelet count , platelet response to adenosine diphosphate , plasma beta thromboglobulin , inactivated complement 3b , neutrophil elastase , fibrinopeptide A , prothrombin fragment F1 . 2 , thrombin antithrombin complex , tissue plasminogen activator , plasminogen activator inhibitor 1 , plasmin alpha 2 antiplasmin complex , and D dimer were obtained at these times : after heparin was given , 5 and 30 minutes after cardiopulmonary bypass was started , within 5 minutes after bypass was stopped , and 15 minutes after protamine was given . ^^^ There were no significant differences between groups at any time for fibrinopeptide A , prothrombin fragment F1 . 2 , or thrombin antithrombin complex or in the markers for fibrinolysis : D dimer , tissue plasminogen activator , plasminogen activator inhibitor 1 , and alpha 2 antiplasmin complex . ^^^ Concentrations of D dimer , alpha 2 antiplasmin complex , and plasminogen activator inhibitor 1 also increased significantly during bypass in both groups . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Capillary labeling of retinal vessel walls for plasminogen activator inhibitor 1 was moderate in both normal and diabetic retinae . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Along the vasculature , extracellular associated vitronectin serves as a binding and stabilizing cofactor for plasminogen activator inhibitor 1 , which thereby becomes a slow reacting thrombin inhibitor . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To evaluate the role of disseminated intravascular coagulation ( DIC ) and to determine the influence of antithrombin , protein C , and plasminogen activator inhibitor 1 on multiple organ dysfunction syndrome ( MODS ) and outcome in patients with systemic inflammatory response syndrome ( SIRS ) , we made a prospective cohort study . ^^^ The global coagulation and fibrinolytic markers , antithrombin , protein C , and plasminogen activator inhibitor 1 were measured on the day of the diagnosis of SIRS , and also on the 1st , 3rd , and 5th days . ^^^ In the nonsurvivors , low levels of protein C and antithrombin and markedly high values of plasminogen activator inhibitor 1 continued up to the 5th day , no improvement of the DIC was observed during the study period and the number of the dysfunctioning organs were significantly higher than in the survivors . ^^^ Plasminogen activator inhibitor 1 on the 5th day had prognostic value for the prediction of death on the SIRS patients . ^^^ Changes in antithrombin , protein C , and plasminogen activator inhibitor 1 are one of the aggravating factors of MODS . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
IGFBP 5 also binds to other proteins in ECM , including type 4 collagen and plasminogen activator inhibitor 1 . ^^^ Specific antisera for plasminogen activator inhibitor 1 can coprecipitate IGFBP 5 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The levels of prothrombin complex , fibrinogen , plasminogen activator inhibitor 1 were increased in women who had previously had severe preeclampsia as compared to those who had had mild preeclampsia ( p < 0 . 01 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Evidence for a relationship between plasminogen activator inhibitor 1 and gamma glutamyl transferase . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Deficiencies in the normal inhibitors of fibrinolysis , such as alpha 2 antiplasmin or plasminogen activator inhibitor 1 , may be underdiagnosed causes of delayed bleeding because they are not identified by the usual coagulation screening tests . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Is plasminogen activator inhibitor 1 the molecular switch that governs urokinase receptor mediated cell adhesion and release . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Besides their atherogenic effect , high insulin levels impair fibrinolysis by enhancing plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In addition to its stimulation of immediate early gene expression , treatment of astrocyte cultures with CGRP stimulated release of the tissue plasminogen activator and led to the accumulation of mRNAs for tissue plasminogen activator and the plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Changes in concentrations of intact and des 31 , 32 proinsulin on metformin were not related to changes in body mass index or fasting glucose concentration or changes in concentrations of total triglyceride , cholesterol , and plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Assays for these proteins or evidence of their function ( antithrombin 3 , protein C , protein S , plasminogen / plasmin , tissue plasminogen activator , plasminogen activator inhibitor 1 , fibrinogen / fibrin degradation products , and thrombin / antithrombin complexes ) are described . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
There was no significant difference in the levels of plasminogen activator inhibitor 1 among the four groups . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
TGF beta 1 , but not bFGF , induced the synthesis of plasminogen activator inhibitor 1 in the myoepithelial cell line . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Extracellular concentrations of eosinophil cationic protein , eosinophil protein 10 , plasminogen activator inhibitor 1 , myeloperoxidase , and interleukin 6 were analyzed by enzyme linked immunosorbent assay and radioimmunoassay . ^^^ Plasminogen activator inhibitor 1 increased threefold to sixfold ( p < 0 . 05 ) in whole blood and plasma reduced whole blood , but not in saline adenine glucose mannitol blood . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 overexpression in nonproliferative diabetic retinopathy . ^^^ Plasminogen activator inhibitor 1 is secreted bidirectionally by endothelial cells , acts as the primary regulator of fibrinolysis and as a key modulator of extracellular matrix proteolysis . ^^^ Elevated serum levels of plasminogen activator inhibitor 1 are observed in serum of diabetic individuals . ^^^ We investigated whether plasminogen activator inhibitor 1 is overexpressed in capillaries of diabetic donors with non proliferative retinopathy compared to non diabetic donors . ^^^ We also assessed plasminogen activator inhibitor 1 expression in an animal model of retinopathy induced by exposing rabbit retinas to insulin like growth factor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
One of the most striking effects of Tat is the induction of a functional program in vascular cells related to angiogenesis and inflammation ( migration , proliferation and expression of plasminogen activator inhibitor 1 and E selectin ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Promoter ( 4G / 5G ) plasminogen activator inhibitor 1 genotype in Pima Indians : relationship to plasminogen activator inhibitor 1 levels and features of the insulin resistance syndrome . ^^^ Elevated plasminogen activator inhibitor 1 may contribute to vascular disease in diabetes mellitus . ^^^ Pima Indians have a low incidence of cardiovascular disease despite having a high prevalence of non insulin dependent diabetes mellitus ( NIDDM ) which in this population is not associated with elevated plasminogen activator inhibitor 1 activity . ^^^ In Caucasians an insertion / deletion ( 4G / 5G ) polymorphism in the promoter region of the plasminogen activator inhibitor 1 gene that has been related to activity levels of its protein in plasma differentially binds repressor and enhancer elements . ^^^ Plasminogen activator inhibitor 1 activities correlated with plasma insulin ( r = 0 . 38 , p < 0 . 0001 ) , body mass index ( r = 0 . 24 , p < 0 . 0001 ) , and with triglyceride level ( r = 0 . 12 , p = 0 . 054 ) but there was no relationship between promotor genotype and activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The fibrinolytic variables , tissue type plasminogen activator , plasminogen activator inhibitor 1 and catecholamine levels were also measured . ^^^ Tissue type plasminogen activator antigen increased ( 31 % , p < 0 . 01 ) , but there was no significant increase in plasminogen activator inhibitor 1 , suggesting an overall increase in fibrinolysis on standing . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Inhibition of plasminogen activator inhibitor 1 activity by two diketopiperazines , XR 330 and XR 334 produced by Streptomyces sp . ^^^ Both compounds inhibited plasminogen activator inhibitor 1 activity in an amidolytic assay of tissue plasminogen activator mediated plasmin generation . ^^^ These diketopiperazines represent the first low molecular weight inhibitors of plasminogen activator inhibitor 1 , a physiological regulator of fibrinolysis . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Several clinical studies revealed that insulin resistance and / or hyperinsulinaemia is associated with hypertension and higher plasma concentrations of uric acid , triglyceride and plasminogen activator inhibitor 1 and with lower HDL cholesterol concentrations . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
No correlation was found between the mean IMT and Lp ( a ) , fibrinogen , tissue plasminogen activator , and plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The two drugs did not show any consistent differences in lipid profile or fibrinogen and plasminogen activator inhibitor 1 levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Increased tissue inhibitor of metalloproteinase 1 and plasminogen activator inhibitor 1 levels suggest that the intrinsic renal activity of the metalloproteinases and serine proteases are inhibited while matrix proteins accumulate in the interstitium . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Levels of antiphospholipid antibodies ( anticardiolipin antibodies and lupus anticoagulant ) , plasminogen activator inhibitor 1 , fibrinogen , antithrombin 3 , protein C , protein S , plasminogen , prothrombin fragment F 1 + 2 , and D dimer were determined for these young women and for 21 age matched white female control subjects without vascular disease and nine white male patients with aortoiliac occlusive disease ( mean 61 years , range 43 to 74 years ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Studies on the role of PPAR in the fibrate modulated gene expression of apolipoprotein A 1 , plasminogen activator inhibitor 1 , and fibrinogen in primary hepatocyte cultures from cynomolgus monkey . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 gene and myocardial infarction . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS AND RESULTS : Exposing endothelium to 40 vol % CM for 10 min did not affect the selected parameters of cellular procoagulant ( tissue factor ) , anticoagulant ( thrombomodulin ) , fibrinolytic ( tissue plasminogen activator ) or antifibrinolytic ( plasminogen activator inhibitor 1 ) activity or antigen . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This seemed to be due to increased synthesis of its inhibitor , plasminogen activator inhibitor 1 , under these conditions rather than to decreased expression of the t PA enzyme . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We here evaluate the effects of some cytokines ( epidermal growth factor , transforming growth factor beta 1 , interleukin 1 alpha , and interleukin 1 beta ) on both cell growth and the production of the aminoterminal peptide of type 3 procollagen , the urokinase plasminogen activator , and the plasminogen activator inhibitor 1 in neoplastic cell lines originating in the pancreas and colon . ^^^ Cells were stimulated daily with the above cytokines and the aminoterminal peptide of type 3 procollagen , urokinase plasminogen activator , and plasminogen activator inhibitor 1 were measured in the conditioned media . ^^^ Transforming growth factor beta 1 counteracted cell proliferation and stimulated type 3 procollagen and plasminogen activator inhibitor 1 production only in the colon cancer cell line . ^^^ Interleukin 1 alpha slightly stimulated cell growth , but inhibited plasminogen activator inhibitor 1 production in both cell lines ; interleukin 1 beta did not affect cell growth , but stimulated plasminogen activator inhibitor 1 production by the colon cancer cell line . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
BACKGROUND : TNK tissue plasminogen activator ( TNK TPA ) is a genetically engineered variant of TPA , which in experimental models has a slower plasma clearance and greater fibrin specificity and is 80 fold more resistant to plasminogen activator inhibitor 1 than alteplase TPA . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Many studies have shown alterations of the hemostatic and fibrinolytic systems in patients with atherosclerotic disease , principally in levels of plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We recently showed that plasminogen activator inhibitor 1 rises after a 20 ml / kg hemorrhage in rats and suggested that this change may be one of the contributing factors to the thrombogenic responses after a large hemorrhage . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The engineered disulfide bond should also prove useful in the creation of more stable serpin variants ; for example , such a bond in plasminogen activator inhibitor 1 would prevent it from becoming latent by locking strand 1C onto the C beta sheet . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The cells produce tissue plasminogen activator , urokinase plasminogen activator , plasminogen activator inhibitor 1 , and urokinase plasminogen activator receptor . ^^^ Incubation with transforming growth factor beta 1 resulted in a decrease in plasminogen activation , primarily because of an increase in plasminogen activator inhibitor 1 RNA and protein and a decrease in u PA RNA as noted by quantitative reverse transcriptase polymerase chain reaction , Western analysis , and zymography . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 accelerates lung metastasis formation of human fibrosarcoma cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Transforming growth factor beta 1 reduced the level of urokinase plasminogen activator and stimulated the secretion of plasminogen activator inhibitor 1 and progelatinase B in both neonatal and fetal fibroblasts . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Instead mRNAs for alpha 1 PI , alpha 1 ACT , and alpha 2 M as well as antithrombin 3 , plasminogen activator inhibitor 1 could be identified by RT PCR using trabecular meshwork culture cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In addition , Smad 4 synergized Smad 2 , as it does with Smad 3 , to induce gene expression from the promoter for plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Pretreatment with rhIL 10 reduced both LPS induced activation of the fibrinolytic system ( plasma concentrations of tissue type plasminogen activator , plasmin alpha 2 antiplasmin complexes , and D dimer ) , and inhibition of fibrinolysis ( plasma levels of plasminogen activator inhibitor 1 ) , whereas posttreatment only inhibited the latter response . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Nonetheless , a growing number of studies have examined the association of CVD with coagulation factors ( fibrinogen , factor 7 , factor 8 , and platelet aggregability ) and fibrinolytic factors [ tissue plasminogen activator , plasminogen activator inhibitor 1 , lipoprotein ( a ) , and plasminogen or global fibrinolytic activity ] . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
RESULTS : In 37 of the obese subjects , who were characterized in detail , the fasting plasma leptin levels correlated with plasma insulin ( 0 . 34 ) but not in a significant way with blood pressure , insulin sensitivity , plasma glucose tolerance or circulating concentrations of glucose , lipoproteins , catecholamines or plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In examination of these markers in deep vein thrombosis , pulmonary embolism , acute myocardial infarction , and cerebral infarction , plasminogen activator inhibitor 1 and activated protein C protein C inhibitor complex were useful marker for the diagnosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This hypothesis is analogous to the concept proposed by Nykjaer et al in which plasminogen activator inhibitor 1 initially binds to uPA to form a complex that secondarily binds to the alpha 2 macroglobulin receptor , leading to internalization of the complex . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Using this approach , the expression of RNAs for tissue type plasminogen activator , urokinase type plasminogen activator , plasminogen activator inhibitor 1 , plasminogen activator inhibitor 2 , protease nexin , and urokinase receptor isoform 1 ( uPAR 1 ) were detected in mouse osteoclasts . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitors 1 and 2 were detected in bile in significantly greater concentrations in patients with gall bladder stones ( plasminogen activator inhibitor 1 : calculous bile median 15 ng / ml versus normal bile < 2 ng / ml , plasminogen activator inhibitor 2 : 157 ng / ml versus < 6 ng / ml , p < 0 . 05 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen dependent and independent proteolytic activity of marine endothelioma ( End ) cells that were derived from mice with targeted inactivation of the tissue type plasminogen activator ( t PA / ) , urokinase type plasminogen activator ( u PA / ) or plasminogen activator inhibitor 1 ( PAI 1 / ) genes was studied with the use of fibrin and extracellular matrix degradation assays . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Our data show that ( 1 ) a pneumatic compression device that exerts its compression on the plantar venous plexus only induced an increase of venous blood peak velocity and flow in the common femoral vein that is very similar to that induced by the classical whole leg boots compression system ; ( 2 ) the venous stasis induced by an external pressure mimicking the conditions of laparoscopic surgery further increased the absolute velocity and flow increase , with the two intermittent compression systems tested ; ( 3 ) no changes of t PA or plasminogen activator inhibitor 1 antigens were observed with either pneumatic compression device . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
However , tissue plasminogen activator , plasminogen activator inhibitor 1 and platelet factor 4 did not show any significant differences from the levels in healthy controls . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Preincubation of cells with IGF 1 or long R 3 IGF 1 divergently changed plasminogen activator inhibitor 1 and 2 secretion , but only IGF 1 blocked IGFBP 3 proteolysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In both groups 3 and 4 , these changes were significantly attenuated with intense immunostaining for plasminogen activator inhibitor 1 ; fibronectin and vitronectin were seen particularly among collagen fibers on both sides of the anastomosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the middle and late phases , significant increases in plasminogen activator inhibitor 1 and antithrombin 3 were observed in HCD rabbits . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In Study 2 highly significant regression coefficients were found between oestradiol minimum ( pretreatment ) and maximum ( median 105 and 4730 pmol / l , respectively ) for coagulation factors FVIII , von Willebrand Factor ( antigen ) , FVII ( activity and antigen ) , fibrinogen , protein C , protein S ( free ) , antithrombin , plasminogen and plasminogen activator inhibitor 1 ; furthermore , between progesterone minimum at day 3 or 2 ( related to ovum pick up ) and maximum ( median 4 . 7 and 98 nmol / l , respectively ) for FVIII , von Willebrand Factor , FVII ( activity and antigen ) , protein C , protein S ( free ) , and plasminogen . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The fat mouse : a powerful genetic model to study elevated plasminogen activator inhibitor 1 in obesity / NIDDM . ^^^ Plasminogen activator inhibitor 1 is elevated in obesity and may be a risk factor for obesity / NIDDM related cardiovascular disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Inhibin specifically counteracted activin induced expression of a plasminogen activator inhibitor 1 promoter element ( 3TP ) and of the junB gene , but was ineffective when the responses were induced by transforming growth factor beta . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The mRNA expression of plasminogen activator inhibitor 1 , a protease inhibitor involved in matrix degradation and stimulated by TGF beta 1 , was observed only in kidneys of rats on a LSD ( P < 0 . 01 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Lp ( a ) also competes with the irreversible inhibitor of plasminogen activators , plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 levels decreased ( 8 AM : 9 . 9 ng / mL , CI 7 . 7 to 12 . 1 ng / mL ; 8 PM : 5 . 4 ng / mL , CI 3 . 8 to 6 . 9 ng / mL ; P < . 005 ) , whereas plasmin plasmin inhibitor complex levels , representing the degree of intravascular plasmin generation , concomitantly increased ( 8 AM : 235 micrograms / L , CI 198 to 272 micrograms / L ; 8 PM : 449 micrograms / L , CI 391 to 507 micrograms / L ; P = . 008 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Both the concentration of plasminogen activator inhibitor 1 antigen and its active subfraction decreased . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Cathepsins B and D reduced the antigens of tissue type plasminogen activator , and they increased both the antigens and the activity of plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To illustrate the method , the interaction of a fusion protein between glutathione S transferase and the DNA binding domain of the helicase like transcription factor with its cis element ( the B box of the plasminogen activator inhibitor 1 promoter ) was determined with both versions : a 1 : 1 stoichiometric interaction with an equilibrium dissociation constant ( Kd ) of 1 nM was found , which is similar to the value determined by electrophoretic mobility shift assay , demonstrating the validity of the assays . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Genetic variation in promoter ( 4G / 5G ) of plasminogen activator inhibitor 1 gene in type 2 diabetes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
V . ) caused a dose related increase ( maximum , 43 52 % at 30 min ) in plasma levels of factor 8 ( FVIII ) , von Willebrand factor ( vWF ) and tissue type plasminogen activator ( t PA ) , but not in levels of plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This study investigated the presence in bovine milk of two serine proteinase inhibitors of the plasmin system , alpha ( 2 ) antiplasmin and plasminogen activator inhibitor 1 , and an isolation procedure used for partial purification of them from milk . ^^^ Plasminogen activator inhibitor 1 and alpha ( 2 ) antiplasmin antigens , which were associated with the inhibitory activities from bovine milk , were visualized by Western blot using commercial polyclonal antibodies raised against the corresponding human inhibitors . ^^^ The predominant forms of the inhibitors in milk exhibited an approximate molecular mass of 60 kDa for alpha ( 2 ) antiplasmin and 55 kDa for plasminogen activator inhibitor 1 . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The treatments did not differ in their effects on collagen induced platelet aggregation and thromboxane production , aggregation to the thromboxane A 2 mimic 1 BOP , urinary excretion of 11 dehydro thromboxane B 2 and beta thromboglobulin , bleeding time , plasma fibrinogen concentration , antithrombin 3 activity , factor 7 coagulant activity , or activity of plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The cardiovascular risk profile ( heart rate ; serum triglycerides ; total , low density lipoprotein , and high density lipoprotein cholesterol ; proinsulin ; uric acid ; plasminogen activator inhibitor 1 antigen and activity ; 24 hour blood pressure monitoring and urinary albumin excretion ) was unaltered by troglitazone treatment . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Aortic SMC were isolated from transgenic mice showing single inactivations of the t PA , u PA , plasminogen activator inhibitor 1 , or urokinase type plasminogen activator receptor ( u PAR ) genes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Although initially tissue plasminogen activator ( t PA ) activity was lower in the aprotinin than placebo group , as surgery proceeded this difference was reversed due to less plasminogen activator inhibitor 1 release in the aprotinin group . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Smads 2 , 3 and 4 accumulated in the nucleus upon TGF beta 1 treatment in Mv1Lu cells , and showed a synergistic effect in a transcriptional reporter assay using the TGF beta inducible plasminogen activator inhibitor 1 promoter . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Serum lipids , lipoprotein lp ( a ) , and plasminogen activator inhibitor 1 in patients with Turner ' s syndrome before and during growth hormone and estrogen therapy . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The population is characterized by extreme leanness ( despite food abundance ) , low blood pressure , low plasma plasminogen activator inhibitor 1 activity , and rarity of cardiovascular disease . ^^^ Plasma fibrinogen , factor 7 clotting activity , factor 8 clotting activity , and von Willebrand factor antigen increased with age in both sexes but plasminogen activator inhibitor 1 activity did not . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Serum levels of total cholesterol , low density lipoprotein cholesterol , apolipoprotein B , and plasminogen activator inhibitor 1 decreased in the male group ( P = 0 . 003 , P = 0 . 03 , P = 0 . 0009 , and P = 0 . 01 , respectively ) , but not in the females . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Preparative induction and characterization of L antithrombin : a structural homologue of latent plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 inhibits smooth muscle cell migration and , in the presence of vitronectin , promotes the clearance of thrombin by LDL receptor related protein at sites of endothelial injury . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Three synthetic pentacosapeptides designated beta 125 ( 41 65 ) , beta 225 ( 41 65 ) , and beta 325 ( 41 65 ) , whose amino acid sequences correspond to the 41st to 65th amino acid residues of TGF beta 1 , TGF beta 2 , and TGF beta 3 , respectively , inhibit the binding of 125I labeled TGF beta isoforms to TGF beta receptors in mink lung epithelial cells with IC 50 of approximately 0 . 06 2 microM . beta 125 ( 41 65 ) blocks TGF beta 1 induced growth inhibition and TGF beta 1 induced plasminogen activator inhibitor 1 expression in these cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Cerebrospinal fluid plasminogen activator inhibitor 1 : a prognostic factor in posthaemorrhagic hydrocephalus . ^^^ The objectives of this study were to investigate whether plasminogen activator inhibitor 1 is detectable in normal or posthaemorrhagic neonatal cerebrospinal fluid and whether higher neonatal cerebrospinal fluid concentrations of plasminogen activator inhibitor 1 are associated with failure of fibrinolytic therapy . ^^^ Cerebrospinal fluid samples from 7 controls and 16 infants with posthaemorrhagic hydrocephalus ( 15 treated with exogenous fibrinolytic agents ) were analysed for plasminogen activator inhibitor 1 . ^^^ Plasminogen activator inhibitor 1 was not detectable in any of the control samples but was detectable in all but one of the posthaemorrhagic samples , and at significantly higher levels in the treatment failures ( median 94 ng ml ( 1 ) ) than in the treatment successes ( median 25 ng ml ( 1 ) ) . ^^^ High levels of plasminogen activator inhibitor 1 in the cerebrospinal fluid are predictive of , and provide a plausible biological explanation for , failure of intraventricular fibrinolytic therapy . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The formation of native homodimers was monitored by nonreducing sodium dodecyl sulfate polyacrylamide gel electrophoresis gradient gels and the bioactivity determined by a quantitative TGF beta assay system using mink lung epithelial cells transfected with a plasminogen activator inhibitor 1 promoter / luciferase reporter plasmid . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 in thrombotic disease . ^^^ Impaired fibrinolytic function , mainly due to an elevation of plasma plasminogen activator inhibitor 1 concentration , is a common finding in patients with thrombotic disease . ^^^ In patients subjected to hip surgery , preoperatively increased levels of plasminogen activator inhibitor 1 seem to be predictive of postoperative deep venous thrombosis . ^^^ Several prospective studies of patients with angina pectoris or a past myocardial infarction have shown strong correlation between plasmatic plasminogen activator inhibitor 1 elevation and future cardiovascular events . ^^^ However , before plasminogen activator inhibitor 1 can be regarded as a risk factor in the conventional epidemiologic sense , its relationship to myocardial infarction must be demonstrated in prospective studies of healthy populations . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have now employed cDNA representational difference analysis to identify four genes ( activity regulated cytoskeletal protein , collagenase 1 , plasminogen activator inhibitor 1 , and VH6 / MKP 3 ) as genes preferentially induced withing 4 hours by NGF in PC 12 cells . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Renal expression of the transgene was localized to the proximal tubule epithelium , and was associated with tubulointerstitial fibrosis , characterized by excessive collagen deposition and increased fibronectin and plasminogen activator inhibitor 1 immunoreactivity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
However , markedly increased plasminogen activator inhibitor 1 levels ( from baseline ) seem to be appropriate tool to confirm the diagnosis of VOD when clinical suspicion exists . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Subjects with hypobetalipoproteinemia ( LDL cholesterol < 70 mg / dL ) had the lowest levels of fibrinogen , plasminogen activator inhibitor 1 antigen , and tissue plasminogen activator antigen . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Seasonal variation with peak fitted values in the winter months was found for plasma viscosity ( P < . 001 for the seasonal difference ) , red blood cell deformability ( P < . 001 ) , whole blood viscosity ( P < . 001 ) , hemoglobin ( P < . 001 ) , hematocrit ( P < . 001 ) , mean corpuscular volume ( P = . 001 ) , platelet count ( P = . 01 ) , alpha 1 glycoprotein ( P < . 001 ) , fibrinogen ( measured by immunonephelometry ; P < . 001 ) , plasminogen activator inhibitor 1 ( P = . 002 ) , LDL cholesterol ( P = . 003 ) , and triglyceride levels ( P < . 001 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Components of the coagulation ( thrombin antithrombin complexes , prothrombin fragment F 1 + 2 , activated factor 7 , and factor 7 antigen ) and fibrinolytic ( fibrin split product D dimer , plasmin plasmin inhibitor complex , tissue type plasminogen activator , urokinase type plasminogen activator , and plasminogen activator inhibitor 1 ) systems and markers of endothelial cell perturbation / dysfunction ( von Willebrand factor and thrombomodulin ) were measured before the start of infusion and after 2 , 6 , 12 , and 24 hours . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The two groups did not differ as to the plasma levels of tissue plasminogen activator or plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
There was no significant difference in age and sex adjusted mean levels of whole blood viscosity , plasma viscosity , haematocrit , von Willebrand factor , fibrin D dimer or plasminogen activator inhibitor 1 activity between the stenosed and no restenosis groups ( p > 0 . 1 ) , but mean plasma fibrinogen was lower in the restenosed group ( 3 . 31 g / l vs . 3 . 75 g / l ; p < or = 0 . 05 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The expression of plasminogen activator inhibitor 1 , a protease inhibitor influenced by TGF beta , followed TGF beta 1 and matrix proteins , suggesting that the fibrosis of chronic FK 506 nephropathy likely involves the dual action of TGF beta 1 on matrix deposition and degradation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
TJN 950 had no effect on expression of uPA , plasminogen activator inhibitor 1 or uPA receptor mRNA . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
These data suggest that this new alpha 1 antichymotrypsin species was in a conformation similar to those of the crystallographically determined latent serpins , plasminogen activator inhibitor 1 and antithrombin . alpha 1 Antichymotrypsin from lung lavage migrated with the same electrophoretic mobility as the putative latent alpha 1 antichymotrypsin , suggesting that this is the inactive conformation described previously in the lungs of patients with chronic bronchitis and emphysema . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Attenuation of thrombolysis induced increase of plasminogen activator inhibitor 1 by intravenous enalaprilat . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Long term follow up of von Willebrand factor and plasminogen activator inhibitor 1 in patients with polymyalgia rheumatica . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The total fibrinolytic activity was increased by nicotinic acid treatment as indicated by decreases in plasminogen activator inhibitor 1 activity from 34 . 3 to 23 . 8 U / ml ( P < 0 . 01 ) and in alpha 2 antiplasmin activity from 1 . 10 to 0 . 97 U / ml ( P < 0 . 01 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Patients with hypodense lesions verified on follow up CT scanning or with persistent neurological deficits at 3 months had higher prothrombin fragments 1 and 2 , TAT , D dimer , and plasminogen activator inhibitor 1 values on the 1st day postoperatively than did patients without such lesions . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Northern blot analysis of RNA from cells cultured for 72 hr under control conditions did not reveal significant differences in steady state concentrations of mRNA for urokinase type PA or plasminogen activator inhibitor 1 , but those for tissue type PA were lower in day 6 cells compared with day 4 and 5 cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Immunolocation of plasminogen activator inhibitor 1 showed a marked , but not significant , increase in bronchiectatic lung as compared to controls . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Interleukin 6 plasminogen activator inhibitor 1 , and tissue plasminogen activator levels were elevated above normal limits on both days in both groups . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
TGF beta 1 inhibited the growth of COLO 357 cells in a time and dose dependent manner and caused a rapid but transient increase in plasminogen activator inhibitor 1 and insulin like growth factor binding protein 3 mRNA levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
At 48 hours postoperatively , the cardiac patients had a more hypercoagulable state than thoracic patients with significantly higher levels of thrombin antithrombin 3 complexes ( p = 0 . 041 ) and plasminogen activator inhibitor 1 activity ( p = 0 . 0033 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Prognostic significance of urokinase type plasminogen activator and plasminogen activator inhibitor 1 in primary breast cancer . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Thrombomodulin levels during normal pregnancy , at delivery and in the postpartum : comparison with tissue type plasminogen activator and plasminogen activator inhibitor 1 . ^^^ The increase of TM levels was correlated with those of tissue type plasminogen activator and plasminogen activator inhibitor 1 antigens . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
UPA was detected in the extracts as pro UPA , UPA complexed to plasminogen activator inhibitor 1 , or as otherwise inactive UPA antigen , but not in the active two chain form . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In this review , we discuss two aspects of the molecular bases of CHD : 1 ) Molecular bases of the candidate gene related to lipoprotein metabolism including apolipoprotein AI CIII AIV gene duster , apolipoprotein B , apolipoprotein E CI CII gene cluster , apolipoprotein ( a ) , LDL receptors , lipoprotein lipase , cholesteryl ester transfer protein , and apo B editing protein ; 2 ) Molecular bases of the candidate gene related to thrombotic and other factors including fibrinogen , factor 7 , plasminogen activator inhibitor 1 , homocysteine , stromelysin , paraoxonase , and angiotensin converting enzyme . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Thrombomodulin , tissue plasminogen activator and plasminogen activator inhibitor 1 in Henoch Schnlein purpura . ^^^ OBJECTIVE : To evaluate the changes in the plasma levels of thrombomodulin ( TM ) , tissue type plasminogen activator ( t PA ) and plasminogen activator inhibitor 1 ( PA 1 1 ) as indices of endothelial injury / activation and fibrinolysis in childhood Henoch Schnlein purpura ( HSP ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
They also had a higher prevalence of hypertension , higher mean levels of fasting serum triglyceride , slightly lower mean levels of serum high density lipoprotein cholesterol , and higher mean levels of plasma plasminogen activator inhibitor 1 and tissue plasminogen activator ( antigen ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Thrombin ( 1 10 U / ml ) induced increased mRNA levels of E selectin , monocyte chemoattractant protein 1 , IL 8 , plasminogen activator inhibitor 1 , and IkappaB alpha . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Association between plasma plasminogen activator inhibitor 1 and survival in colorectal cancer . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
MAIN OUTCOME MEASURES : Concentrations of haemoglobin , tissue type plasminogen activator and plasminogen activator inhibitor 1 ; activated partial thromboplastin time ; prothrombin time ; platelet and reticulocyte counts ; blood loss ; and transfusions . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
E selectin levels correlated with triglycerides , tissue plasminogen activator and plasminogen activator inhibitor 1 activity in all groups . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In this study , we have investigated whether secretion of the urokinase plasminogen activator , urokinase plasminogen activator receptor , and plasminogen activator inhibitor 1 in normal kidney tissue and kidney cancer tissue follows this pattern . ^^^ We have found that urokinase plasminogen activator , urokinase plasminogen activator receptor , and plasminogen activator inhibitor 1 were expressed in higher levels in kidney cancers ( squamous cell carcinoma and renal cell carcinoma ) than in normal kidney tissue and that these differences were statistically significant ( P < or = 0 . 05 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Higher plasma levels of low density lipoprotein cholesterol ( P < 0 . 01 ) and low density lipoprotein triglycerides ( P < 0 . 05 ) , a lower plasma high density lipoprotein 2 cholesterol level ( P < 0 . 05 ) and higher plasma plasminogen activator inhibitor 1 activity ( P < 0 . 05 ) , together with a high baseline stenosis score ( P < 0 . 001 ) characterized patients with severe progression of coronary atherosclerosis . ^^^ On the other hand , more pronounced fasting and post prandial glycaemia ( P < 0 . 05 ) , together with higher plasma plasminogen activator inhibitor 1 activity ( P < 0 . 01 ) characterized severe progressors with respect to coronary stenosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We have analyzed the transcriptional activity of the human plasminogen activator inhibitor 1 promoter in the fission yeast Schizosaccharomyces pombe . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Seventy two hours after initial infection , both the procoagulant activity of MC and the activity of the fibrinolytic inhibitor ( plasminogen activator inhibitor 1 ) in the supernatants were enhanced . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
These include vasodilators ( nitric oxide , prostacyclin , endothelium derived hyperpolarizing factor ) , vasoconstrictors ( endothelin 1 , thromboxane A 2 , prostaglandin H 2 and components of the renin angiotensin system ) , various pro and antithrombotic factors ( e . g . tissue factor , platelet activating factor PAF , von Willebrand factor ) , fibrinolytic activators and inhibitors ( e . g . tissue plasminogen activator , plasminogen activator inhibitor 1 ) , potent arachidonate metabolites ( prostanoids ) , leukocyte adhesion molecules ( e . g . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Severe heat stroke associated with high plasma levels of plasminogen activator inhibitor 1 . ^^^ In a 38 year old man , severe heat stroke caused disseminated intravascular coagulation ( DIC ) associated with significantly elevated plasma plasminogen activator inhibitor 1 levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We identified 12 up regulated distinct genes including 5 cell growth related genes ( two phosphatases CL 100 and B23 / hVH 3 , gravin , activating transcription factor 4 , and heparin binding epidermal growth factor like growth factor ) , 3 thrombosis related genes ( plasminogen activator inhibitor 1 , tissue plasminogen activator , and thrombomodulin ) , and 4 others ( stanniocalcin , NAD dependent methylenetetrahydrofolate dehydrogenase / methenyltetrahydrofolate cyclohydrolase , BENE , and reducing agents and tunicamycin responsive protein ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The alpha 2 plasmin inhibitor and plasminogen activator inhibitor 1 levels were significantly ( p < 0 . 05 ) greater in the minimal dose and low dose groups than in the control group after bypass , suggesting the prevention of fibrinolysis by both aprotinin doses . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Data from animal and human studies of pulmonary hypertension provide evidence for increased platelet activation , decreased platelet survival , increased release of von Willebrand factor antigen without an increase in activity , decreased soluble thrombomodulin and a net loss of fibrinolytic activity with excessive release of plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We compared the fibrinolytic activities of IVEC and HUVEC , and observed that IVEC express a more profibrinolytic phenotype than HUVEC , since they bind and activate plasminogen more efficiently , produce more tissue plasminogen activator and urokinase type plasminogen activator antigens , and secrete less plasminogen activator inhibitor 1 antigen both under basal conditions and after stimulation with lipopolysaccharide , phorbol ester and tumor necrosis factor . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
All except five patients had normal plasminogen activator inhibitor 1 levels . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Cyclic variation , increased expression by estradiol and progesterone , and regulation of plasminogen activators and plasminogen activator inhibitor 1 . ^^^ Both TGFbeta 1 and estradiol + progesterone increased the content of plasminogen activator inhibitor 1 mRNA and protein in primary cultures of endometrial stromal cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Postprandial TRL are potentially thrombogenic because they are associated with increased activated factor 7 activity ( a procoagulant effect ) and increased levels of plasminogen activator inhibitor 1 ( an antifibrinolytic effect ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
TNF alpha also reduces lipoprotein lipase activity in white adipocytes , stimulates hepatic lipolysis , and increases plasminogen activator inhibitor 1 content in adipocytes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Functional variants of angiotensin 1 converting enzyme ( ACE ) , beta fibrinogen , plasminogen activator inhibitor 1 , methylenetetrahydrofolate reductase , glycoprotein Illa , and many apolipoprotein genes are considered excellent candidate risk factors for MI . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Cell motility is significantly reduced by inhibitors of u PA proteolytic activity such as antibodies neutralizing u PA activity , plasminogen activator inhibitor 1 , and amiloride . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Vitronectin , an adhesive blood glycoprotein , has the potential to modulate this system by its known capacity to interact with plasminogen activator inhibitor 1 , plasminogen activators , the urokinase plasminogen activator receptor , and plasminogen . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Metabolic factors usually associated with insulin resistance , including increased 2 hour post oral glucose tolerance test triglycerides , smaller low density lipoprotein particle size , and increased plasminogen activator inhibitor 1 , were present in white ( all P < . 05 ) but surprisingly absent in Sikh ( all P > . 05 ) MI patients compared with respective ethnic control subjects . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In HC treated endothelial cells , pulse chase studies revealed a doubling in the rate of synthesis of the thiol containing protein , annexin 2 , but no change in synthesis of the cysteineless protein , plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In contrast , endothelium activation , characterized by increased levels of tissue plasminogen activator , plasminogen activator inhibitor 1 , and von Willebrand Factor antigen was blunted by both low and high dose TNFR : Fc ( p < 0 . 001 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
All of these cells also secreted a 100 fold greater amount of plasminogen activator inhibitor 1 than of uPA antigen , and uPA activities were not detected in the culture medium . ^^^ The secretion of uPA and plasminogen activator inhibitor 1 from HLMECs was also enhanced by tumor necrosis factor alpha and IL 2 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Seeding fibroblasts on ED A FN does not elicit per se alpha SM actin expression ; however , incubation of fibroblasts with the anti ED A monoclonal antibody IST 9 specifically blocks the TGFbeta 1 triggered enhancement of alpha SM actin and collagen type 1 , but not that of plasminogen activator inhibitor 1 mRNA . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the present study , we determined the plasma and tissue concentrations of tissue type plasminogen activator , urokinase type plasminogen activator , plasminogen activator inhibitor 1 , plasminogen activator inhibitor 2 and urokinase type plasminogen activator receptor in 32 patients with pathology proved gastric cancer . ^^^ Plasma plasminogen activator inhibitor 1 was significantly higher in gastric cancer than in benign gastric disease ( p < 0 . 0005 ) , whereas plasma urokinase type plasminogen activator was significantly lower in patients with gastric cancer than in those with benign ulcer ( p = 0 . 003 ) . ^^^ The plasma and tissue levels of fibrinolytic parameters were not affected by tumor size or distant metastasis , whereas tumor tissue concentration of urokinase type plasminogen activator receptor and plasminogen activator inhibitor 2 were significantly higher in N 0 than in N 1 and N 2 , and tissue plasminogen activator inhibitor 1 was significantly higher in N 0 than in N 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The plasma tissue factor and plasminogen activator inhibitor 1 levels were not significantly changed before the onset of DIC . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Because higher ACE has been reported to be associated with higher plasminogen activator inhibitor 1 activity , our observation suggests that the genotype of the ACE gene is a marker of fibrinolytic activity . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Either of these mutations abolished plasminogen activator inhibitor 1 protein expression stimulated by granulocyte / macrophage colony stimulating factor activation of chimeric heteromeric type 1 type 2 TGFbeta receptors . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The positions and phases of the exon ? ntron borders are completely conserved between neuroserpin and its nearest homologues , protease nexin 1 and plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Association between plasma concentrations of plasminogen activator inhibitor 1 and survival in patients with colorectal cancer . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In 33 children with acute lymphoblastic leukaemia the following parameters were determined : plasminogen activator inhibitor 1 , plasminogen , antiplasmin , protein C , antithrombin , modified antithrombin , prothrombin fragments 1 + 2 and thrombinantithrombin complex . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The activated Tg also exerted a small but significant TGF beta agonist activity in transcriptional activation of plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The binding of VEGF B to its receptor on endothelial cells leads to increased expression and activity of urokinase type plasminogen activator and plasminogen activator inhibitor 1 , suggesting a role for VEGF B in the regulation of extracellular matrix degradation , cell adhesion , and migration . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In contrast , HRI inhibited plasminogen activator inhibitor 1 activity and mRNA . ^^^ C 3 exoenzyme , an inhibitor of the geranylgeranylated activated Rho protein , reproduced the effect of lovastatin on tPA and plasminogen activator inhibitor 1 activity and blocked its reversal by geranylgeranyl pyrophosphate . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Abeta ( 1 40 ) bovine serum albumin conjugate ( Abeta ( 1 40 ) BSA ) , a multivalent synthetic analogue of Abeta aggregates , exhibited cytotoxicity toward bovine cerebral endothelial cells and rat post mitotic differentiated hippocampal neuronal cells ( H 19 7 cells ) and inhibitory activities of radiolabeled TGF beta binding to TGF beta receptors and TGF beta induced plasminogen activator inhibitor 1 expression , that were approximately 100 670 times more potent than those of Abeta ( 1 40 ) monomers . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This finding is clearly indicative for an activation of the coagulation pathway . ( 2 ) Patients with the hemolytic uremic syndrome have significantly higher D dimer levels , a sensitive marker of fibrin specific fibrinolysis , as compared to patients with acute renal failure of other causes ( P < 0 . 005 ) . ( 3 ) Levels of plasminogen activator inhibitor 1 ( active antigen as well as plasminogen activator inhibitor 1 activity ) are not different in both patient groups . ^^^ In contrast , plasma levels of tissue type plasminogen activator and urokinase type plasminogen activator are significantly higher in the hemolytic uremic patients than in those with acute renal failure of other causes ( P < 0 . 01 and P < 0 . 05 respectively ) . ( 4 ) Hemodialysis leads to an increase in tissue type plasminogen activator antigen and a decrease of plasminogen activator inhibitor 1 activity levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The growth of Renca cells , in tissue culture , was not sensitive to the inhibitory effect of TGF beta 1 with doses ranging from 0 . 1 to 10 ng . / ml . , nor was this cell line sensitive to the effect of TGF beta 1 in inducing the expression of plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Smad4 / DPC4 and Smad 3 mediate transforming growth factor beta ( TGF beta ) signaling through direct binding to a novel TGF beta responsive element in the human plasminogen activator inhibitor 1 promoter . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The aim of our study was to measure fibrinogen and fibrin degradation products ( D dimer ) , interleukin 6 tissue plasminogen activator , plasminogen activator inhibitor 1 and urokinase type plasminogen activator in the plasma and arterial walls of 45 patients who had arterial surgery between April 1993 and November 1995 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : Blood pressure and other variables were determined , including fibrinogen level , coagulation factor 7 clotting activity , protein C level , antithrombin 3 level , plasminogen activator inhibitor 1 level , euglobulin fibrinolytic activity , and von Willebrand factor level . ^^^ RESULTS : Age adjusted mean values of coagulation factor 7 clotting activity , plasminogen activator inhibitor 1 level , antithrombin 3 level , and protein C level in hypertensives and borderline hypertensives were significantly higher than those in normotensive men ( e . g . for hypertensive versus normotensive men , coagulation factor 7 clotting factor activity 111 . 5 versus 106 . 1 % , plasminogen activator inhibitor 1 level 5 . 05 versus 3 . 22 arbitrary units / ml , and protein C level 111 . 1 versus 107 . 0 % , P < 0 . 05 0 . 01 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
An increased production of plasminogen activator inhibitor 1 and an increase in platelet aggregability may explain the higher risk of coronary thrombosis in subjects with high levels of ACE . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 4G / 4G genotype is associated with cerebral sinus thrombosis in factor 5 Leiden carriers . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : Fibrinolytic activity in shed mediastinal blood was compared with that in the system blood in 5 patients after cardiac operation by measuring fibrinogen , fibrin degradation product , plasminogen activator inhibitor 1 , and alpha 2 antiplasmin levels . ^^^ This was indicated by the mediastinal blood ' s lower fibrinogen levels ( 0 . 47 versus 1 . 91 U / mL ; p < 0 . 001 ) , very high levels of fibrin degradation products ( 1 , 350 versus 200 ng / mL ; p < 0 . 05 ) , and higher levels of plasminogen activator inhibitor 1 ( 55 . 5 versus 28 . 1 ng / mL ; p < 0 . 005 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 : a common denominator in cardiovascular disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We now show that TRIP 1 expression represses the ability of TGF beta to induce transcription from the plasminogen activator inhibitor 1 promoter , a common reporter of the TGF beta induced gene expression response , but does not affect the ability of TGF beta to inhibit cyclin A transcription . ^^^ TRIP 1 can also inhibit the plasminogen activator inhibitor 1 expression induced by Smads as well as activated TGF beta type 1 receptors . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
No differences between groups , however , could be observed with respect to partial thromboplastin time , prothrombin time , platelets , plasminogen activator inhibitor 1 , soluble tumor necrosis factor receptor 2 , neutrophil elastase , interleukin ( IL ) 1 receptor antagonist , IL 6 , and IL 8 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Other measured variables included time to ischemia on exercise treadmill testing , ischemia on 48 h ambulatory electrocardiogram ( ECG ) monitoring , and resting and mental stress induced levels of plasma catecholamines , tissue plasminogen activator antigen , plasminogen activator inhibitor 1 and platelet aggregability . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Platelet aggregation and plasminogen activator inhibitor 1 activity peak around the time of awakening . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Using rat myoblasts as a model system , we found that overexpression of endoglin led to a decreased TGF beta response to cellular growth inhibition and plasminogen activator inhibitor 1 synthesis , whereas overexpression of betaglycan resulted in an enhanced response to inhibition of cellular proliferation and plasminogen activator inhibitor 1 induced expression in the presence of TGF beta . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Stimulation of AT 1 receptors is associated with endothelial dysfunction , mainly as the consequence of an increased vascular production of superoxide radicals , vasoconstriction , platelet activation , enhanced release of plasminogen activator inhibitor 1 , activation of immediate early genes c fos and c jun , myocyte hypertrophy , connective tissue formation , endothelin 1 synthesis , and activation of growth factors like PDGF and TGF beta 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
RESULTS : Neither the amount nor type of fat consumed influenced plasminogen activator inhibitor 1 or t plasminogen activator activities or D dimer concentration . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This study evaluated the regulation of fibrinolytic activity defined by tissue plasminogen activator and plasminogen activator inhibitor 1 as it may exist in the setting of acute vascular rejection . ^^^ MATERIALS AND METHODS , RESULTS : Serial biopsies from cardiac xenotransplants evaluated by immunofluorescence microscopy demonstrated progressive decreases in tissue plasminogen activator and increases in plasminogen activator inhibitor 1 . ^^^ The shift is at least partly explained by an increased ratio of plasminogen activator inhibitor 1 to tissue plasminogen activator , and is at least in part mediated by the activation of complement . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 in thrombotic disease ] . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fibrinogen Bbeta chain , factor 7 , and plasminogen activator inhibitor 1 gene polymorphisms have been reported to influence the plasma levels of these factors and may indirectly be risk factors for arterial thrombotic disorders . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Metastatic conversion correlated with upregulation of urokinase type plasminogen activator receptor RNA expression and downregulation of plasminogen activator inhibitor 1 , collagen alpha 1 ( 1 ) , and cytokeratin 14 ( K 14 ) RNA expression . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The acute phase reactants C reactive protein and interleukin 6 , and markers of the fibrinolytic state ( plasminogen activator inhibitor 1 and tissue plasminogen activator ) , are also elevated in the acute coronary syndromes and in healthy individuals at increased risk for developing coronary artery disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A CAGACA sequence shown to be a functional Smad binding element in the plasminogen activator inhibitor 1 gene promoter was found within the TGF beta response region of the proximal COL1A2 promoter . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
TNK is a mutant of tissue plasminogen activator ( t PA ) with high fibrin specificity , resistance to plasminogen activator inhibitor 1 and slow plasma clearance , which is administered in a single intravenous bolus . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The expression of plasminogen activator inhibitor 1 and fibronectin in the kidneys of dTGR were increased and distributed similarly to ICAM 1 . ^^^ Interestingly , the drugs were all equally effective in preventing monocyte / macrophage infiltration and the overexpression of adhesion molecules , plasminogen activator inhibitor 1 , and fibronectin in the kidney . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
RESULTS : Hormone replacement therapy during 1 year caused a marginal but significant increase in plasma concentration of factor VIIc after 12 months of treatment ( P < . 05 ) , a significant decrease in fibrinogen , and a significant decrease in the protein concentrations of tissue type plasminogen activator , plasminogen activator inhibitor 1 , and lipoprotein ( a ) after 3 , 6 , and 12 months of treatment ( P < . 05 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
These genes included ( a ) known regulators of mesangial cell activation in diabetic nephropathy ( fibronectin , caldesmon , thrombospondin , and plasminogen activator inhibitor 1 ) , ( b ) novel genes , and ( c ) known genes whose induction by high glucose has not been reported . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
When added to confluent HUVEC , factor Xa induced the expression of tissue factor and the release of tissue type plasminogen activator and plasminogen activator inhibitor 1 without affecting urokinase expression . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Also associated with preeclampsia is a loss of endothelial cell integrity , with the consequent increase in vascular permeability , and an increase in the circulating levels of the endothelial cell markers , fibronectin , von Willebrand factor , tissue plasminogen activator , and plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
No breed effect was detected for the amounts of gelatinases and plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
PAP was negatively related to factors associated with the insulin resistance syndrome ( IRS ) ( eg , fasting insulin , r= 0 . 26 ; body mass index , r= 0 . 26 ) , possibly reflecting an association with plasminogen activator inhibitor 1 ( r= 0 . 29 ) . ^^^ Although PAP reflects reactive fibrinolysis and is associated with subclinical atherosclerosis , this relationship may be weaker in populations with characteristics of the IRS , possibly reflecting the inhibitory effects of plasminogen activator inhibitor 1 on PAP . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Using the primary dermal fibroblasts , we also demonstrate that Smad 3 is integral for induction of endogenous plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Other hemostasis parameters , including plasminogen activator inhibitor 1 , plasminogen , fibrinogen , hemoglobin , hematocrit , and blood cell counts were comparable for alpha 2 AP+ / + , alpha 2 AP+ / , and alpha 2 AP / mice . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Haemostasis and fibrinolysis function were estimated by analysis of von Willebrand factor , plasminogen activator inhibitor 1 , antiplasmin and fibrinogen . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fibrinolysis in ischemic cardiopathy : the role of plasminogen activator inhibitor 1 ] . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
After further adjustment for waist circumference ( marker of visceral adiposity ) , insulin resistant subjects continued to have higher plasminogen activator inhibitor 1 and VLDL triglyceride levels , lower HDL cholesterol levels , and smaller LDL particle size than did insulin sensitive subjects . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Elevated concentrations of the fibrinolytic inhibitor plasminogen activator inhibitor 1 are associated with insulin resistance . ^^^ In experimental systems , increased expression and secretion of plasminogen activator inhibitor 1 by hepatocyte and endothelial cell lines can be induced by insulin , proinsulin like molecules , triglyceride rich lipoproteins and oxidized LDL , as well as by inducing insulin resistance in isolated hepatocytes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Concentration of plasminogen activator inhibitor 1 was 50 % lower in both using groups ( P < 0 . 001 ) compared with nonusers , and this was associated with higher plasmin antiplasmin complex : 8 % higher in estrogen and 18 % higher in estrogen / progestin users ( P < 0 . 05 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Platelet count , antithrombin , fibrinogen , prothrombin fragment F1+2 , soluble thrombomodulin , tissue plasminogen activator , D dimer , and plasminogen activator inhibitor 1 antigen were investigated . ^^^ Plasminogen activator inhibitor 1 antigen was significantly higher in patients with Crohn ' s disease than in those with ulcerative colitis and was higher in the patient group treated with steroids . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Although treatment with ethanol alone did not affect t PA gene transcription or mRNA expression , it augmented isoproterenol ( ISO ) stimulated t PA gene transcription and mRNA levels by 3 . 4 and 2 . 8 fold , respectively , and decreased plasminogen activator inhibitor 1 mRNA levels by 65 % . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Most recently , direct induction of plasminogen activator inhibitor 1 by angiotensin has been recognized . ^^^ Plasminogen activator inhibitor 1 not only promotes thrombosis , but also inhibits matrix degradation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Cultured blood monocytes also express both the tissue plasminogen activator and the plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 in central serous chorioretinopathy . ^^^ PURPOSE : To describe the plasma level of plasminogen activator inhibitor 1 , the major antifibrinolytic agent , in eyes with central serous chorioretinopathy , in which choroidal thrombosis is suspected as the underlying condition based on the findings of choroidal hyperpermeability in indocyanine green angiograms . ^^^ METHODS : Plasminogen activator inhibitor 1 concentrations in the plasma of 17 patients with central serous chorioretinopathy were measured by enzyme linked immunosorbent assay and compared with those in 12 age matched normal volunteers . ^^^ RESULTS : The plasma levels of plasminogen activator inhibitor 1 in patients with central serous chorioretinopathy ( range , 25 to 439 ng / ml ; median , 87 ng / ml ) were significantly increased compared with those in normal volunteers ( range , 7 to 84 ng / ml ; median , 36 ng / ml ) ( P = . 0013 , Mann Whitney U test ) . ^^^ CONCLUSION : Increased plasminogen activator inhibitor 1 concentrations in patients with central serous chorioretinopathy support the hypothesis that the choroidal hyperpermeability disclosed by indocyanine green angiography is caused from impaired fibrinolysis and the resulting thrombotic occlusion in the choroidal veins . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
TGF beta appeared to induce also membrane bound uPA activity and the release of active plasminogen activator inhibitor 1 , indicating that TGF beta has the potential to regulate plasminogen activation at the RPE cell surface . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Abnormal response to methionine loading was associated with higher tissue plasminogen activator ( tPA ) mass concentration , higher plasminogen activator inhibitor 1 levels , and lower tPA activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The list of proteins includes those known to be produced by keratinocytes ( beta 2 microglobulin , betaIG H 3 , calgranulin A , cathepsin B and D , E cadherin , gelatinase B , gelsolin , interstitial collagenase , laminin B2t , plasminogen activator inhibitor 1 , protein 14 3 3epsilon , SCC antigen , stratifin , and translationally controlled tumor protein ) as well as those not previously known to be secreted by keratinocytes ( epididymis secretory protein , maspin , and anti neoplastic urinary protein ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Further , insulin significantly stimulated plasminogen activator inhibitor 1 activity in EC . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Increased plasminogen activator inhibitor 1 and vasculopathy . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Baseline thrombogenic blood tests included 6 hemostatic variables ( D dimer , fibrinogen , factor 7 , factor VIIa , von Willebrand factor , and plasminogen activator inhibitor 1 ) , 7 lipid factors [ cholesterol , triglycerides , HDL cholesterol , LDL cholesterol , lipoprotein ( a ) , apolipoprotein ( apo ) A 1 , and apoB ] , and insulin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A concomitant enhancement of tissue plasminogen activity resulted in significant increases in tissue plasminogen activity antigen and total fibrin / fibrinogen degradation products , and a significant decrease in tissue plasminogen activator inhibitor 1 activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 activity was normalized on the low GI diet , ( 54 % , P < 0 . 001 ) , but remained unchanged on the high GI diet . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
As fasting insulin concentrations increased , postloading insulin , glucose , blood pressure , body mass index , waist to hip ratio , total cholesterol , triglycerides , LDL cholesterol , apoprotein B , plasminogen activator inhibitor 1 , tissue plasminogen activator , and fibrinogen increased , but lipoprotein ( a ) , HDL cholesterol , and apoprotein A 1 decreased . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This was associated with a substantial decrease in plasminogen activator inhibitor 1 activity from 10 . 4 ( 8 . 5 to 16 . 7 ) to 6 . 4 ( 5 . 6 to 9 . 2 ) IU / mL ( P=0 . 009 ) . ^^^ During CsA , but not azathioprine , plasma tissue plasminogen activator antigen and plasminogen activator inhibitor 1 levels correlated significantly with prostaglandin E 2 ( r=0 . 53 , P=0 . 02 ; and r=0 . 60 , P=0 . 008 , respectively ) , and thromboxane B 2 ( r=0 . 75 , P=0 . 0001 ; and r=0 . 77 , P=0 . 0001 , respectively ) levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The absence of any significant increase in plasminogen activator inhibitor 1 antigen perioperatively ( anova , P=0 . 348 ) suggests the observed hypercoagulability is not due to a ' fibrinolytic shutdown ' reported in other forms of surgery . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Dyslipidemia interacts with associated hemodynamic ( i . e . hypertension ) and metabolic abnormalities ( i . e . increased platelet aggregation and plasminogen activator inhibitor 1 levels ) to promote CVD risks in diabetic women . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : A series of hemostatic tests and parameters including activated partial thromboplastin time , prothrombin time , thrombin time , bleeding time , factor 8 assay , antithrombin activity , fibrinogen , plasminogen , protamine sulfate test , fibrin ( ogen ) degradation products , D dimer , thrombin antithrombin complex ( measured by modified antithrombin ) , tissue plasminogen activator ( tPA ) , plasminogen activator inhibitor 1 , euglobulin lysis test and venous occlusion test were performed in 51 patients with cirrhosis of the liver and 33 healthy controls . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Furthermore , uPA is prognostic in node negative patients , and a clinical trial is currently under way to assess whether uPA and its inhibitor , plasminogen activator inhibitor 1 , can differentiate between the majority of node negative breast cancer patients who are cured by surgery from the minority who might benefit from adjuvant therapy . uPA is also prognostic in other malignancies , such as gastric , colorectal , esophageal , renal , endometrial , and ovarian cancers . uPA may thus be a prognostic indicator for multiple types of adenocarcinoma . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This is similar to the amount of plasminogen activator inhibitor 1 produced by these cells , which also produce tissue plasminogen activator and urokinase . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To investigate whether or not this cascade is present during delayed wound healing and contributes to the pathophysiological basis of impaired healing we examined the temporal expression of urokinase plasminogen activator , plasminogen activator inhibitor 1 and gelatinase B in fluid collected from chronic venous leg ulcers compared to acute surgical mastectomy wounds . ^^^ Levels of active plasminogen activator inhibitor 1 in chronic wounds were four times higher than those found in sera and two times higher than those found in mastectomy wound fluid . ^^^ Using a fibrin overlay system and reverse zymography , we found that when the wound was not healing , the expression of urokinase plasminogen activator in chronic wound fluid was initially detected in the active forms ( 50 and 33 kDa ) , but that as the wound healed and decreased in size , was detected as an inhibitor bound urokinase plasminogen activator plasminogen activator inhibitor 1 complex ( congruent with 80 116 kDa ) . ^^^ When the expression of active urokinase plasminogen activator was highest , no plasminogen activator inhibitor 1 was detectable . ^^^ In contrast , urokinase plasminogen activator was always detected in the inhibitor bound form as a urokinase plasminogen activator plasminogen activator inhibitor 1 complex in blood and plasma derived serum and mastectomy wound fluid . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
MAPK may mediate the effects of insulin and angiotensin 2 on VSMC production of plasminogen activator inhibitor 1 , which attenuates fibrinolysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
These effects were shown to extend to the physiological tPA inhibitor , plasminogen activator inhibitor 1 . tPA . plasminogen activator inhibitor 1 complex did not compete tPA binding to VSMC , and the inhibition of bound tPA was reduced by 30 fold . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Hyaluronan fragments induce plasminogen activator inhibitor 1 and inhibit urokinase activity in mouse alveolar macrophages : a potential mechanism for impaired fibrinolytic activity in acute lung injury . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Additionally , activated protein C enhances tissue plasminogen activator mediated fibrinolysis by inhibition of plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Addition of IL 6 blocked TGF beta induced activation of caspase 3 while showing no effect on the induction of plasminogen activator inhibitor 1 and p 15 ( INK4B ) genes , indicating that IL 6 interferes with only a subset of TGF beta activities . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
CRP was also associated with other variables of the insulin resistance syndrome , including blood pressure , insulin , high density lipoprotein cholesterol , triglycerides , apolipoprotein A 1 ( inversely ) , plasminogen activator inhibitor 1 antigen , and tissue type plasminogen activator antigen . ^^^ Associations between CRP and the variables of the insulin resistance syndrome disappeared after controlling for BMI but remained significant for plasminogen activator inhibitor 1 antigen only . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The rapid activation of p42 / 44 MAP kinase ( MAPK ) by TGF beta 1 was eliminated completely , and transcriptional activation by TGF beta 1 of the plasminogen activator inhibitor 1 gene was reduced by 50 % in both endothelial cells and Mv1Lu when they were infected with AdCARasY 57 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Expression of uPA , uPA receptor , and plasminogen activator inhibitor 1 were determined by Western blot and enzyme linked immunosorbent assay . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Moreover , when compared to subjects without such family history , a higher number of homozygotes for the T allele of the MTHFR gene ( p = 0 . 027 ) , and of the 4G allele of the plasminogen activator inhibitor 1 gene ( p = 0 . 002 ) was found in the subsetting of the offspring of patients with myocardial infarction . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
PI 6 , also known as cytoplasmic antiprotease , has been characterized as an intracellular inhibitor of trypsin and chymotrypsin like proteases , which has high homology to plasminogen activator inhibitor 1 and 2 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
RESULTS : Mean plasma viscosity ( an index of blood rheology , ANOVA , P = 0 . 001 ) , von Willebrand factor ( an index of endothelial damage , P = 0 . 013 ) , plasminogen activator inhibitor 1 and lipoprotein ( a ) ( both markers of thrombogenesis ; Kruskal Wallis test , both P < 0 . 001 ) were all significantly raised in ISH and SDH relative to controls . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 showed no circadian variation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue plasminogen activator , plasminogen activator inhibitor 1 , interleukin 1beta , interleukin 6 , plasma tissue factor , and factor 5 levels were measured . ^^^ Plasminogen activator inhibitor 1 levels peaked at 4 hours after CPB and returned to baseline by 24 hours . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The procoagulant response is magnified by concomitant suppression of fibrinolysis by hypoxia mediated upregulation of plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In addition to cardiological and angiological examinations , the lipid status and levels of fibrinogen , plasma viscosity , F 1+2 , plasminogen , plasminogen activator inhibitor 1 , D dimer , and C reactive protein of the participants were determined . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 significantly decreased at 3 and 6 months of follow up : by 12 . 6 % and 18 . 7 % , respectively , in women , and by 18 . 8 % and 23 . 5 % , respectively , in men . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Prothrombotic state and elevated levels of plasminogen activator inhibitor 1 in mitral stenosis with and without atrial fibrillation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma urokinase antigen and plasminogen activator inhibitor 1 antigen levels predict angiographic coronary restenosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 activity was reduced with exercise in both groups but with a significantly greater decrease observed in the nonusers ( P < . 0001 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Using surface plasmon resonance , we studied the binding of these fragments to methylamine activated alpha ( 2 ) macroglobulin , pro urokinase type plasminogen activator , tissue type plasminogen activator ( t PA ) , plasminogen activator inhibitor 1 , t PA . plasminogen activator inhibitor 1 complexes , lipoprotein lipase , apolipoprotein E , tissue factor pathway inhibitor , lactoferrin , the light chain of blood coagulation factor 8 , and the intracellular chaperone receptor associated protein ( RAP ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fluvastatin therapy was associated with a small reduction in factor 7 coagulant activity , von Willebrand factor , and in plasminogen activator inhibitor 1 and tissue plasminogen activator antigens , but the effects of fluvastatin on hemostatic factors were much less marked than its effects on plasma lipids . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Obesity , microalbuminuria , hyperinsulinemia , and increased plasminogen activator inhibitor 1 activity associated with parasympathetic neuropathy in type 2 diabetes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The mRNA levels of insulin receptor , IRS 1 , Glut 4 , lipoprotein lipase , hormone sensitive lipase , acylation stimulating protein , fatty acid transport protein 1 , angiotensinogen , plasminogen activator inhibitor 1 , and PPARgamma 1 and gamma 2 were not modified by rosiglitazone treatment . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In men , estrogen appears to have a similar effect on other lipids and lipoproteins and on plasminogen activator inhibitor 1 as in women . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Specificity in transforming growth factor beta induced transcription of the plasminogen activator inhibitor 1 gene : interactions of promoter DNA , transcription factor muE 3 , and Smad proteins . ^^^ We show that Smad 3 selectively binds to two of the three SBEs in PE2 . 1 , a TGF beta inducible fragment of the plasminogen activator inhibitor 1 promoter , to mediate TGF beta induced transcription ; moreover , a precise 3 bp spacer between one SBE and the E box , a binding site for transcription factor muE 3 ( TFE 3 ) , is essential for TGF beta induced transcription . ^^^ Together , these studies elucidate an important mechanism for specificity in TGF beta induced transcription of the plasminogen activator inhibitor 1 gene . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Smad 4 expression in these cells failed to rescue TGF beta antiproliferative and gene responses ( c myc down regulation and induction of p21 / Cip1 and plasminogen activator inhibitor 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In contrast , compared with mRNA in the lateral meniscus , that for types 2 and 3 collagen , biglycan , insulin like growth factor 2 , plasminogen activator inhibitor 1 , and matrix metalloprotease 1 was significantly increased in the medial meniscus of mature rabbits only and that for versican and type 1 collagen was significantly increased in the medial meniscus of immature rabbits only . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue type plasminogen activator urokinase type plasminogen activator and plasminogen activator inhibitor 1 mRNA were expressed in glioma cells during the entire tumor growth . ^^^ Our finding may suggest a functional co operation of tissue type plasminogen activator , urokinase type plasminogen activator , plasminogen activator inhibitor 1 and vascular endothelial growth factor during glioma progression . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In agreement with this , activin A induced low levels of plasminogen activator inhibitor 1 expression compared to the high induction by TGF ( beta ) 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Only 3 transcripts of 5000 were induced > 2 . 5 fold : cyclooxygenase 1 , tenascin C , and plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In contrast to raloxifene , from 6 months on CEEs increased high density lipoprotein cholesterol by 0 . 25 to 0 . 29 mmol / L and reduced plasminogen activator inhibitor 1 antigen by 30 . 6 to 48 . 6 ng / mL ( all P < 0 . 02 versus both placebo and raloxifene ) . ^^^ These treatments differ , however , in their effects on high density lipoprotein cholesterol , triglycerides , and plasminogen activator inhibitor 1 and possibly in their effects on prothrombin fragment F1+2 and C reactive protein . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The log of lipoprotein ( a ) level was negatively related to the rate of plasmin formation ( r ( s ) = 0 . 46 , P=0 . 002 ) , and multiple regression analysis indicated that this relationship was not influenced by the amount of plasminogen , fibrinogen , plasminogen activator inhibitor 1 , tissue plasminogen activator , or by the size of apo ( a ) isoforms . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 , a possible link between insulin resistance syndrome and coronary heart disease , may decrease due to physical training or low fat diet . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Of the genes studied , urokinase type plasminogen activator and plasminogen activator inhibitor 1 were regulated in RPE cells similar to fibroblasts at senescence . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Angiotensin 2 stimulates plasminogen activator inhibitor 1 and directly causes endothelial dysfunction . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The plasminogen activator inhibitor 1 gene , hypofibrinolysis , and osteonecrosis . ^^^ The plasminogen activator inhibitor 1 gene was shifted toward homozygosity for the 4G polymorphism ; 41 % of patients with osteonecrosis were homozygous for the 4G / 4G polymorphism versus 20 % of 40 healthy control subjects . ^^^ Heritable hypofibrinolysis conferred by the 4G / 4G mutation of the plasminogen activator inhibitor 1 gene seems to be a major pathoetiology of primary osteonecrosis . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Hemostatic parameters were not significantly affected by fenofibrate , except for a 12 15 % decrease ( p < 0 . 05 ) in fibrinogen levels in the fasted and fed state , and a significant increase ( 43 % ; p < 0 . 05 ) in fasting levels of plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Importantly , seven of eight cases had a raised level of plasminogen activator inhibitor 1 , a well known inhibitor of fibrinolysis related to obesity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We measured CRP , fibrinogen , plasminogen activator inhibitor 1 , total cholesterol , triglycerides , and some genetic polymorphisms : plasminogen activator inhibitor 1 ( 4G / 5G ) , fibrinogen ( Bbeta chain G > A ( 455 ) ) , and angiotensin converting enzyme insertion / deletion ( I / D ) . ^^^ When compared with subjects without first degree relatives who had suffered a myocardial infarction ( n=867 ) , subjects with such first degree relatives ( n=181 ) were older ( P=0 . 001 ) , more often hypertensive ( P < 0 . 001 ) , and homozygous for the 4G allele ( 4G / 4G ) of the plasminogen activator inhibitor 1 gene ( P=0 . 003 ) . ^^^ In a multiple logistic regression analysis , age ( odds ratio [ OR ] 1 . 03 , 95 % confidence interval [ 95 % CI ] 1 . 01 to 1 . 05 ) , total cholesterol ( OR 1 . 35 , 95 % CI 1 . 11 to 1 . 65 ) , plasminogen activator inhibitor 1 4G / 4G ( OR 1 . 72 , 95 % CI 1 . 20 to 2 . 45 ) , and CRP levels > 0 . 33 mg / L ( OR 1 . 75 , 95 % CI 1 . 05 to 2 . 91 ) were all independently associated with a positive family history of myocardial infarction . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fibrinogen correlated positively with white blood cells ( WBC ) ( r = 0 . 25 ) , prothrombin fragment 1 . 2 ( F1 . 2 ) ( r = 0 . 21 ) , cholesterol ( r = 0 . 27 ) , beta thromboglobulin ( r = 0 . 29 ) , Factor 7 clotting activity ( FVIIc ) ( r = 0 . 27 ) ( all P < 0 . 0001 ) , tissue plasminogen activator antigen ( t PAag ) ( r = 0 . 22 , P < 0 . 0005 ) , plasminogen activator inhibitor 1 antigen ( PAI 1ag ) ( r= 0 . 20 ) and VCAM 1 ( r= 0 . 19 ) ( both P < 0 . 002 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This effect was blocked by plasminogen activator inhibitor 1 , by tPA STOP , and by co incubation with tPA antibody . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NO can also affect the fibrinolytic activity by regulating the release of tissue type plasminogen activator and plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
On the other hand , TGF beta 1 did not affect the synthesis of extracellular matrix regulatory enzymes and their inhibitors , such as type 2 transglutaminase , matrix metalloproteinase 2 , plasminogen activator inhibitor 1 , or tissue inhibitor of matrix metalloproteinase 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Effect of plasminogen activator inhibitor 1 4G / 5G polymorphism in Turkish deep vein thrombotic patients with and without FV 1691 G A . ^^^ A decreased fibrinolytic activity due to increased levels of plasminogen activator inhibitor 1 has been shown in deep vein thrombosis patients . ^^^ Elevated plasma plasminogen activator inhibitor 1 levels are associated with the 4G allele of a 4G / 5G polymorphism located in the promoter region of the plasminogen activator inhibitor 1 gene . ^^^ DNA was extracted by conventional methods , and polymerase chain reaction of the plasminogen activator inhibitor 1 4G / 5G polymorphism was performed according to a previously described method . ^^^ Genotype distributions of FV 1691G A and plasminogen activator inhibitor 1 4G / 5G are as follows : plasminogen activator inhibitor 1 4G ( patients ) 0 . 562 , plasminogen activator inhibitor 1 4G ( controls ) 0 . 50 ( p = 0 . 6 ) ; FV1691A ( patients ) 0 . 147 , FV1691A ( controls ) 0 . 035 ( p = 0 . 005 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Whereas global assays to study coagulation have existed for many years , there has been no simple , rapid , and economic routine test for the plasmatic fibrinolysis parameters plasminogen activator inhibitor 1 , alpha 2 antiplasmin , plasminogen , and aprotinin . ^^^ The plasmatic fibrinolysis parameters activity correlates negatively ( r = 0 . 684 ) with the plasminogen activator inhibitor 1 activity of patient samples . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Deformation increased transforming growth factor beta 1 ( TGF beta 1 ) and plasminogen activator inhibitor 1 gene expression sevenfold at two days , but mannose 6 phosphate did not affect cell proliferation , indicating that endogenous TGF beta is not involved in the proliferative response . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The role of angiotensin 2 and plasminogen activator inhibitor 1 in progressive glomerulosclerosis . ^^^ Plasminogen activator inhibitor 1 has been shown to be the major inhibitor of tissue plasminogen activator and urokinase like plasminogen activator , with potentially important effects not only on thrombosis / fibrinolysis , but also on matrix degradation because of the proteolytic actions of these substances . ^^^ Angiotensin 2 has been shown to influence the actions of plasminogen activator inhibitor 1 and , consequently , its thrombotic and sclerotic effects . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Pocket protein independent repression of urokinase type plasminogen activator and plasminogen activator inhibitor 1 gene expression by E2F1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Ovine large luteal cells may be the primary type of cell responsible for controlling the extent of remodelling of luteal ECM since they produce TIMP 1 , TIMP 2 and plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
TNK tPA is a triple combination mutant of wild type tissue plasminogen activator that exhibits a longer plasma half life , an enhanced fibrin specificity , and an increased resistance to the plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The temporal profiles of the expression of these genes were different from those of other angiogenic genes such as basic fibrobast growth factor / fibroblast growth factor receptor and vascular endothelial growth factor / vascular endothelial growth factor receptor and proteolytic enzymes ( tissue type plasminogen activator and urokinase plasminogen activator ) and their inhibitors ( plasminogen activator inhibitor 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The percentage increase in plasma plasminogen activator inhibitor 1 activity on the first postoperative day was significantly higher in patients who subsequently were found to have vein graft occlusion ( p < 0 . 05 ) . ^^^ A perturbed plasma plasminogen activator inhibitor 1 response to coronary artery bypass grafting tentatively could be added to the vessel specific factors that remain the main determinants of early vein graft closure . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tissue plasminogen activator antigen concentration decreased significantly ( p < 0 . 01 ) only in the metformin group , but this was not significantly different from the placebo group ( p < 0 . 12 ) ; further , there were no significant differences in the change in plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Ang 2 also enhanced plasminogen activator inhibitor 1 expression , which inhibits metalloproteinases that degrade the extracellular matrix . ^^^ Ang 2 plays a novel role in stimulation of plasminogen activator inhibitor 1 expression and adhesion of cardiac fibroblasts to collagen . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In myocytes iron caused a dose dependent decline in mRNAs coding for transforming growth factor beta ( 1 ) ( TGF beta ( 1 ) ) , biglycan , and collagen type 1 while plasminogen activator inhibitor 1 mRNA was unaffected by iron loading and decorin mRNA doubled . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Before HD , plasma protein C and protein S antigens were almost within the normal range , while plasma thrombin antithrombin 3 complex ( TAT 3 ) and plasmin plasmin inhibitor complex ( PPIC ) levels in HD patients were increased slightly , and plasminogen activator inhibitor 1 level was significantly increased , compared to that in normal volunteers . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The endothelial damage markers of soluble thrombomodulin , soluble P selectin ( p < 0 . 05 vs . normal ) , plasminogen activator inhibitor 1 and tissue factor were elevated in heparin induced thrombocytopenia and antiphospholipid antibody syndrome patients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
At these sites , colocalization with plasminogen activator inhibitor 1 was seen . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
TNK tissue plasminogen activator ( TNK t PA ) , a bioengineered variant of tissue type plasminogen activator ( t PA ) , has a longer half life than t PA because the glycosylation site at amino acid 117 ( N117Q , abbreviated N ) has been shifted to amino acid 103 ( T103N , abbreviated T ) and is resistant to inactivation by plasminogen activator inhibitor 1 because of a tetra alanine substitution in the protease domain ( K296A / H297A / R298A / R299A , abbreviated K ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Other hemostatic and fibrinolytic parameters that are predictive of coronary events include factor 7 , platelet hyperreactivity , plasminogen activator inhibitor 1 , and tissue plasminogen activator . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS AND RESULTS : Exposure of ECs to complement caused upregulation of mRNAs for E selectin , intracellular adhesion molecule 1 , vascular cell adhesion molecule 1 , Ikappa Balpha , interleukin ( IL ) 1alpha , IL 1beta , IL 8 , and plasminogen activator inhibitor 1 over a period of 6 hours . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Coordinate regulation of the serpin plasminogen activator inhibitor 1 was also apparent ; however , a net increase in uPA activity was predominant . alpha ( 3 ) beta ( 1 ) integrin clustering induced extracellular signal regulated kinase 1 / 2 phosphorylation , and both uPA induction and extracellular signal regulated kinase activation were blocked by the mitogen activated protein kinase / extracellular signal regulated kinase kinase inhibitor PD 98059 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Butyrate induced a ninefold increase in urokinase receptor expression and twofold increase in urokinase activity , while culture alone induced a significantly smaller increase in receptor expression , an increase in plasminogen activator inhibitor 1 but no change in activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This region of the COL1A2 promoter contains a CAGA motif also found in the promoter of the plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 4G / 5G promoter polymorphism and coagulation factor 7 Arg 353 > Gln polymorphism in Korean patients with coronary artery disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Serial measurements of coagulation variables ( prothrombin time , activated partial thromboplastin time , FVII activity , fibrinogen , tissue factor activity ) , anticoagulant proteins ( protein C , antithrombin ) and fibrinolytic factors ( tissue plasminogen activator , plasminogen activator inhibitor 1 ) were performed for 5 h . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The authors envision that limiting such prenylated proteins downregulates thrombin stimulated events , including decreasing the expression and availability of protease activated receptor 1 mitigating thrombin stimulation of cells , tissue factor preventing additional thrombin generation , and plasminogen activator inhibitor 1 allowing thrombosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Yet , studies associating myocardial infarction with gene polymorphisms of vascular proteins ( angiotensinogen , angiotensin converting enzyme , angiotensin 2 type 1 receptor , endothelial nitric oxide synthase ) and haemostatic factors ( fibrinogen , coagulation factors 2 , 5 , 7 and 13 , plasminogen activator inhibitor 1 , tissue type plasminogen activator , platelet glycoproteins IIb / IIIa , Ia / IIa and Ib 9 5 , or methylenetetrahydrofolate reductase ) have revealed conflicting results . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Only oral ethinyl estradiol plus CA but neither transdermal 17beta estradiol plus CA , nor oral CA , nor parenteral testosterone lowered plasma tPA and plasminogen activator inhibitor 1 ( P < 0 . 001 for both ) . tPA release during venous occlusion was not affected by oral ethinyl estradiol plus CA in males ( P=0 . 52 ) or by parenteral testosterone in females ( P=0 . 89 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
With change from baseline the main outcome measure , HRT increased the markers of coagulation ( prothrombin fragments 1+2 , 0 . 20+ / 0 . 06 versus 0 . 06+ / 0 . 04 nmol / L , P=0 . 0005 ; soluble fibrin , 2 . 3+ / 0 . 4 versus 0 . 25+ / 0 . 3 microgram / mL , P=0 . 0004 ) , reduced plasma fibrinolytic inhibitory activity ( plasminogen activator inhibitor 1 , 0 . 67+ / 0 . 16 versus 0 . 24+ / 0 . 21 U / mL , P=0 . 002 ) , and increased fibrinolysis ( D dimer , 24+ / 12 versus 6+ / 8 ng / mL , P=0 . 04 ) compared with placebo . ^^^ Increases in soluble fibrin and D dimer were positively correlated ( r=0 . 59 , P=0 . 02 ) , but changes in plasminogen activator inhibitor 1 and D dimer were unrelated . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Activated protein C protein C inhibitor complex and plasminogen activator inhibitor 1 were useful for the diagnosis of DVT , PE , AMI or CT . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Ski repressed TGF beta induced expression of 3TP Lux , the natural plasminogen activator inhibitor 1 promoter and of reporter genes driven by the SBE and the related CAGA element . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the present study we have expressed four other members of the serpin family : alpha 1 antitrypsin , C 1 inhibitor , plasminogen activator inhibitor 1 and antithrombin in MDCK cells . ^^^ Tight monolayers of transfected cells were grown on filters and the amounts of recombinantly expressed serpins in the apical and the basolateral media were determined . alpha 1 Antitrypsin and C 1 inhibitor were found mainly in the apical medium whereas plasminogen activator inhibitor 1 and antithrombin were found in roughly equal amounts in the apical and basolateral media . ^^^ We conclude that some members of the serpin family including corticosteroid binding globulin , alpha 1 antitrypsin and C 1 inhibitor are secreted mainly apically from MDCK cells whereas plasminogen activator inhibitor 1 and antithrombin are secreted in a non polarized manner . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Although the levels of von Willebrand factor and plasminogen activator inhibitor 1 showed essentially the same changes in both groups during and after percutaneous transluminal coronary angioplasty , more markedly increased levels of tissue type plasminogen activator and type plasminogen activator plasminogen activator inhibitor 1 complex after percutaneous transluminal coronary angioplasty were found in group 1 than in group 2 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The following parameters were altered at 6 months in both patients with `` adequate ' ' and `` inadequate ' ' LDL C reduction : ( 1 ) tissue plasminogen activator decreased by 1 . 4 + / 0 . 4 and 1 . 5 + / 0 . 5 ng / ml respectively ( p = NS ) ; ( 2 ) plasminogen activator inhibitor 1 decreased by 8 . 7 + / 2 . 0 and 10 . 1 + / 2 . 7 ng / ml respectively ( p = NS ) ; ( 3 ) thrombus formation under dynamic flow conditions decreased by 3 . 5 + / 0 . 9 and 2 . 8 + / 1 . 2 microm 2 10 10 ( 3 ) respectively ( p = NS ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A 7 fold increase in plasminogen activator inhibitor 1 activity was observed after both morning ( P < 0 . 05 ) and evening ( P < 0 . 01 ) intakes of alcohol . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Though Western blots confirmed the presence of plasminogen activator inhibitor 1 protein throughout wound repair and reverse zymograms showed decreased plasminogen activator inhibitor 1 activity between days 7 and 14 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We stably transfected into these cells the luciferase reporter plasmid carrying promoter of the plasminogen activator inhibitor 1 gene , the expression of which is stimulated by TGF beta 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
One of them , plasminogen activator inhibitor 1 , was overproduced in accumulated visceral fat and might contribute to the development of vascular disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Droloxifene also reduced fibrinogen by 17 . 8 % versus a 7 . 3 % reduction with estrogen ( P=0 . 004 ) but produced no estrogen like changes in plasminogen , plasminogen activator inhibitor 1 , or tissue plasminogen activator . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Increased plasma plasminogen activator inhibitor 1 in relatives of type 2 diabetic patients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In a univariate analysis , XIIa correlated with total cholesterol , triglycerides , plasminogen activator inhibitor 1 , and C reactive protein ( CRP ) , although the presence of conventional cardiovascular risk factors ( male sex , smoking , hypertension , hypercholesterolemia , diabetes ) did not significantly increase XIIa . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Co treatment with the serine protease inhibitors aprotinin or plasminogen activator inhibitor 1 also suppressed the cytostatic activity of TPA approximately 50 % . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The interaction between HKa or domain 5 with VN was prevented by heparin , plasminogen activator inhibitor 1 , and a recombinant glutathione S transferase ( GST ) fusion peptide GST VN ( 1 77 ) consisting of the amino terminal portion of VN ( amino acids 1 77 ) , but not by a cyclic arginyl glycyl aspartyl peptide , indicating that HKa interacts with the amino terminal portion of VN ( `` somatomedin B region ' ' ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 : defining characteristics in the cerebrospinal fluid of newborns . ^^^ We measured plasminogen activator inhibitor 1 levels in the cerebrospinal fluid and plasma of newborns with and without posthemorrhagic hydrocephalus . ^^^ We found that plasminogen activator inhibitor 1 levels in the cerebrospinal fluid of healthy newborns are < 10 mg / mL but are greatly elevated in patients who have posthemorrhagic hydrocephalus and correlate directly with cerebrospinal fluid D dimer and protein levels . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Under basal conditions , brain capillary protein C activation and tissue plasminogen activator activity were reduced in spontaneously hypertensive rats compared with Wistar Kyoto rats by 11 . 8 fold ( P < 0 . 001 ) and 5 . 1 fold ( P < 0 . 001 ) , respectively , and the plasminogen activator inhibitor 1 antigen and tissue factor activity were increased by 154 fold ( P < 0 . 00001 ) and 74 % ( P < 0 . 01 ) , respectively . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma levels of tissue type plasminogen activator activity peaked at 1 . 5 hours ( 11 . 3 fold increase ) , whereas the peak of plasminogen activator inhibitor 1 activity ( 14 fold increase at 4 . 5 hours ) was delayed compared to tissue plasminogen activator and completely extinguished plasma tissue plasminogen activator activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
There was no significant correlation ( r = 0 . 11 ) between secretion of adipose plasminogen activator inhibitor 1 and glucose transport . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Relationship between plasminogen activator inhibitor 1 antigen , leptin , and fat mass in obese children and adolescents . ^^^ We studied whether body fatness , leptin , and insulin interact with plasminogen activator inhibitor 1 antigen ( PAI 1 Ag ) and tissue type plasminogen activator antigen ( tPA Ag ) in obese children and adolescents . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This small effect was not specific for TSP 1 : matrix metalloproteinase 2 , tissue inhibitor of matrix metalloproteinase 2 and active plasminogen activator inhibitor 1 , but not transglutaminase , human serum albumin or immunoglobulin , had quantitatively similar effects on latent TGF beta 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The plasma levels of plasminogen activator inhibitor 1 antigen , thrombomodulin , tissue factor pathway inhibitor antigen , fibrinogen , and factor 12 were determined before and after 6 months of therapy . ^^^ The reduction , however , of fibrinogen , plasminogen activator inhibitor 1 , and thrombomodulin was significantly greater in the irbesartan than in the atenolol group . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Also , the increase in plasminogen activator inhibitor 1 level and impaired fibrinolysis were related with the D / D genotype . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
AgLDL release was decreased > 90 % by inhibitors of plasmin ( epsilon amino caproic acid and anti plasminogen mAb ) , and also by inhibitors of urokinase plasminogen activator ( plasminogen activator inhibitor 1 and anti urokinase plasminogen activator mAb ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
TSF 1 did not directly activate a Smads dependent promoter from plasminogen activator inhibitor 1 gene , but it showed enhancement in co operation with Smad 3 and Smad 4 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fibrinolysis was assessed through measurement of the activities of the rate limiting fibrinolytic activator , tissue plasminogen activator , and its inhibitor plasminogen activator inhibitor 1 with amidolytic methods . ^^^ RESULTS : On the day before surgery , plasminogen activator inhibitor 1 activity was elevated in all groups in comparison with that in age matched and sex matched controls ( 20 . 3 + / 0 . 6 AU / mL ) . ^^^ In the HEP group , plasminogen activator inhibitor 1 activity was further elevated above the value for the day before surgery on postoperative day 1 ( 28 . 5 + / 4 . 3 AU / mL ; P = . 04 ) and postoperative day 3 ( 25 . 1 + / 1 . 9 AU / mL ; P = . 07 ) . ^^^ No significant decrease in plasminogen activator inhibitor 1 activity occurred in either group treated with EPC devices in comparison with the HEP group at any time . ^^^ CONCLUSIONS : Reduced systemic fibrinolytic activity ( `` fibrinolytic shutdown ' ' ) occurred in these patients after abdominal surgery ; it was manifested as increased plasminogen activator inhibitor 1 activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Parallel increases in tissue plasminogen activity and antigen with a concomitant decrease in tissue plasminogen activator inhibitor 1 activity were also observed after exercise . ^^^ Although no demonstrable effect of alcohol on tissue plasminogen activator activity was present from 1 hour after ingestion onward , tissue plasminogen activator antigen and tissue plasminogen activator inhibitor 1 antigen increased significantly 22 hours following alcohol ingestion . ^^^ Further comparison between trials revealed a higher plasminogen activator inhibitor 1 activity 5 hours after alcohol ingestion . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Results were compared with those of fibrinogen and plasminogen activator inhibitor 1 ; cardiovascular risk factors in men and women accounted for 16 % and 9 . 5 % , respectively , of the fibrinogen variance and 36 % and 32 % , respectively , of the plasminogen activator inhibitor 1 variance . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The Ki value for rMaspin ( 1 ) in cell surface mediated plasminogen activation was 20 nM , which was comparable to the Ki values for plasminogen activator inhibitor 1 and plasminogen activator inhibitor 2 , respectively . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The plasma concentrations of plasminogen activator inhibitor 1 in the diabetic patients tended toward higher than those in the healthy subjects . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Job strain was measured with the Job Content Questionnaire ; CVD risk was measured with insulin , total cholesterol , triglyceride ( TG ) , high density lipoprotein cholesterol ( HDL C ) , fibrinogen , tissue type plasminogen activator ( tPA ) antigen , tPA activity , plasminogen activator inhibitor 1 antigen , and blood pressure . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fibrinolysis is activated in this process by the action of tumor necrosis factor alpha , but its activity is impaired by the predominant inhibitory effect of plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
South Asians had an increased prevalence of glucose intolerance , higher total and LDL cholesterol , higher triglycerides , and lower HDL cholesterol , and much greater abnormalities in novel risk factors including higher concentrations of fibrinogen , homocysteine , lipoprotein ( a ) , and plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Upregulation of CTGF coincided with an increase in fibronectin , collagen type 1 and plasminogen activator inhibitor 1 production . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
CLIF , a novel cycle like factor , regulates the circadian oscillation of plasminogen activator inhibitor 1 gene expression . ^^^ Plasminogen activator inhibitor 1 activity shows a circadian oscillation and may account for the morning onset of myocardial infarction . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
RESULTS : As estimated from the measurements on placebo , type 1 diabetic patients , as compared to the controls , had some impairment of endothelial function : plasma tissue type plasminogen activator levels were lower ( 3 . 5 vs . 5 . 4 ng mL ( 1 ) , P < 0 . 05 ) , but there were no significant differences in brachial artery flow mediated vasodilation or plasma levels of von Willebrand Factor , endothelin 1 , plasminogen activator inhibitor 1 , soluble E selectin or vascular cell adhesion molecule 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Certain ACE inhibitors may exert positive effects by modulating plasminogen activator inhibitor 1 , endothelial function , and left ventricular remodeling . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Recombinant TGH 2 expressed in baculovirus shows a low level of binding to TGF beta receptor bearing mink lung epithelial cells ( MELCs ) , which is partially inhibited ( 16 to 39 % ) with human TGF beta , and activates plasminogen activator inhibitor 1 transcription in MELCs , a marker for TGF beta mediated transduction . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In both models , we found an increased expression of tissue factor , tissue factor pathway inhibitor , urokinase plasminogen activator , and plasminogen activator inhibitor 1 , as well as thrombin receptor . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In short term clinical studies , very low sodium intake ( < 50 mmol / d ) has been associated with greater values for total and low density lipoprotein cholesterol , fasting and post glucose insulin , uric acid , plasminogen activator inhibitor 1 , and activity of the renin angiotensin system . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Thromboangitis obliterans with plasminogen activator inhibitor 1 suppression by PGE 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A suppression subtraction cDNA library representing mRNAs expressed at a higher level in a benign breast tumour derived cell line relative to the malignant MCF 7A cell line contained cDNAs corresponding to mRNAs for plasminogen activator inhibitor 1 , annexin 8 and the EF hand protein S100A2 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In addition , R 20 showed a significantly negative correlation with plasma levels of fibrinogen and plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Coagulation tests included determinations of the prothrombin time , the activated partial thromboplastin time , the thrombin time , the thrombin antithrombin complex , the prothrombin fragment F 1 + 2 , the tissue plasminogen activator , the plasminogen activator inhibitor 1 , protein C activity and free protein S antigen . ^^^ Elevated concentrations of the prothrombin fragment F 1 + 2 , the thrombin antithrombin complex , D Dimer , tissue plasminogen activator and plasminogen activator inhibitor 1 were detected in most of the children . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Infusion therapy with PGE 1 for 4 weeks led to a decrease of all hemostatic and fibrinolytic parameters with most pronounced changes for PFT1+2 , D dimers and plasminogen activator inhibitor 1 decreasing by 11 % ( P < 0 . 05 ) , 20 % ( P < 0 . 05 ) , and 7 % ( P < 0 . 05 ) , respectively . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Losartan had no effect on plasma concentrations of plasminogen activator inhibitor 1 and von Willebrand factor in hypertensive subjects . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
That the urokinase plasminogen activator ( uPA ) was involved in the activation of procollagenase 1 was suggested by findings that the 120 kDa Fn fragment induced uPA coordinately with procollagenase 1 , and the activation of procollagenase 1 was dose dependently inhibited in the presence of plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This randomized , double blind trial found that tissue plasminogen activator activity increased and plasminogen activator inhibitor 1 activity decreased significantly more with exercise during placebo treatment than during treatment with beta blockade . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
There was no difference in the levels of urokinase type plasminogen activator , plasminogen activator inhibitor 1 and 2 , tissue inhibitor of metalloproteinases 2 or vascular endothelial growth factor . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tenecteplase is a genetically engineered variant of alteplase with slower plasma clearance , better fibrin specificity , and high resistance to plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
RESULTS : After adjustment for age , fat mass correlated significantly with plasminogen activator inhibitor 1 antigen ( PAI 1 Ag ) in boys and girls and factor VIIc only in girls . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Another group , including bovine serum albumin , ovalbumin , alpha synuclein , and plasminogen activator inhibitor 1 ( PAIRC ) peptide , undergo structural transformation with an increase of beta sheet structure in the solid state . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The following tests were performed : platelet count , platelet aggregation , platelet flow cytometry for CD 62 and CD 63 , usual coagulation tests , thrombin antithrombin complexes , plasminogen activator inhibitor 1 . ^^^ Greater amounts of plasminogen activator inhibitor 1 were detected at T 3 and T 4 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Factor 7 coagulant activity ( VIIc ) and factor 8 coagulant activity ( VIIIc ) were determined using one stage clotting assays ; fibrinogen was measured according to the method of Clauss ; von Willebrand factor antigen ( vWF Ag ) , tissue type plasminogen activator antigen ( tPA Ag ) , and plasminogen activator inhibitor 1 antigen ( PAI 1 Ag ) were determined by ELISA . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Different structural requirements for plasminogen activator inhibitor 1 ( PAI 1 ) during latency transition and proteinase inhibition as evidenced by phage displayed hypermutated PAI 1 libraries . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Insulin resistance syndrome comprises insulin resistance and compensatory hyperinsulinaemia as well as hypertension , dyslipidaemia , macrovascular disease , and increased plasminogen activator inhibitor 1 activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The supernatants were assayed for antigens of tissue and urokinase plasminogen activator and plasminogen activator inhibitor 1 and 2 . ^^^ The activities of tissue plasminogen activator and plasminogen activator inhibitor 1 were assayed by ELISA . ^^^ Frozen sections were immunostained for tissue and urokinase plasminogen activators and for plasminogen activator inhibitor 1 . ^^^ Plasminogen activator inhibitor 1 did not differ significantly between the groups . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
No change occurred in HDL cholesterol , apo B100 / apo A 1 ratio , plasminogen activator inhibitor 1 , factor VIIc , von Willebrand factor , fibrinogen , lipoprotein ( a ) , glucose , HbA1c , or 24 h blood pressure . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
When compared to patients with benign breast conditions there was a far greater plasma level of factor 8 vWF , fibrinogen , thrombin antithrombin 3 complex , D dimer fibrin degradation products , tissue type plasminogen activator and the activity and the antigen of plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
MS 275 treatment enhanced TGF beta 1 induced plasminogen activator inhibitor 1 expression . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 functions as a urokinase response modifier at the level of cell signaling and thereby promotes MCF 7 cell growth . ^^^ Plasminogen activator inhibitor 1 ( PAI 1 ) is a major inhibitor of urokinase type plasminogen activator ( uPA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Extending the capabilities of targeted molecular dynamics : simulation of a large conformational transition in plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 clustered with the body mass factor , supporting the hypothesis that obesity is related to impaired fibrinolysis . ^^^ The authors conclude that should hemostatic variables be shown to contribute to IRS related cardiovascular disease , apart from plasminogen activator inhibitor 1 , they may do so independently of the established metabolic abnormalities . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
High levels of the plasminogen activators , but also their inhibitor , plasminogen activator inhibitor 1 ( PAI 1 ) , have been documented in neovascularization of severe ocular pathologies such as diabetic retinopathy or age related macular degeneration ( AMD ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Finally , we show that purified SPARC increased mRNA levels of plasminogen activator inhibitor 1 ( PAI 1 ) in cultured rat adipose tissue suggesting that elevated adipocyte expression of SPARC might contribute to the abnormal expression of PAI 1 observed in obesity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Population analysis of g . 2488delG and three novel polymorphisms ( g . 4497G > A , g . 4503G > A and g . 2319G > A ) in the plasminogen activator inhibitor 1 ( PAI 1 ) gene . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Regulation of plasminogen activator inhibitor 1 expression by interaction of epidermal growth factor with progestin during decidualization of human endometrial stromal cells . ^^^ Decidual cell expressed plasminogen activator inhibitor 1 is appropriately positioned to avert implantational hemorrhage . ^^^ Because of the absence of estrogen or progesterone response elements from the plasminogen activator inhibitor 1 gene promoter , 1 posited that epidermal growth factor mediates these steroid effects and that expression of epidermal growth factor receptor in human endometrial stromal cells is under ovarian steroid control . ^^^ After 40 hours the cultures were analyzed for plasminogen activator inhibitor 1 protein and messenger ribonucleic acid expressions . ^^^ RESULTS : In the absence of steroids , epidermal growth factor did not alter plasminogen activator inhibitor 1 expression . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Oxygen modulates the release of urokinase and plasminogen activator inhibitor 1 by retinal pigment epithelial cells . ^^^ The aims of this study were to examine the effect of oxygen , in the presence or absence of exogenous growth factors , on the release of plasminogen activators and plasminogen activator inhibitor 1 by cultured human retinal pigment epithelial cells . ^^^ After 48 h , urokinase levels were highest at normoxia , reaching 7 . 2ng / 10 ( 6 ) cells ( + / 2 . 0 SEM ) , whereas plasminogen activator inhibitor 1 levels were highest at hyperoxia , reaching 67 . 5ng / 10 ( 6 ) cells ( + / 3 . 7 SEM ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
South Asians had an increased prevalence of glucose intolerance , higher total and low density lipoprotein cholesterol , higher triglycerides and lower high density lipoprotein cholesterol , and much greater abnormalities in novel risk factors including higher concentrations of fibrinogen , homocysteine , lipoprotein ( a ) , and plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Enhanced expression of plasminogen activator inhibitor 1 in patients with nephrotic syndrome . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Induction of plasminogen activator inhibitor 1 gene expression in adipocytes by thiazolidinediones . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In addition , the 4G / 5G promoter polymorphism of the gene coding for plasminogen activator inhibitor 1 ( PAI 1 ) , the known ligand of LRP with strong antifibrinolytic potential , was ascertained to investigate its possible association with CAD . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Thrombogenicity was assessed by measurement of plasma fibrinogen , soluble P selectin ( an index of platelet activation ) , plasminogen activator inhibitor 1 ( PAI 1 , an index of fibrinolysis ) and von Willebrand factor ( an index of endothelial dysfunction ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In isolated TbetaRI and TbetaRII expressing peritoneal macrophages , the activated TGF beta 1 induces the expression of the plasminogen activator inhibitor 1 ( PAI 1 ) , whereas in the mast cells , the levels of TbetaRI , TbetaRII , and PAI 1 expression were below detection . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
These cells showed reduced invasiveness that paralleled decreased mRNA levels of urokinase type plasminogen activator and its receptor , tissue type plasminogen activator , and plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
There were no significant changes in plasminogen activator inhibitor 1 activity between crush and sham after the injury . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVES : To study the effect of weight loss and subsequent weight maintenance or weight regain on the activities of FVII and plasminogen activator inhibitor 1 ( PAI 1 ) and the concentration of fibrinogen over 12 months in obese women consuming a hypoenergetic , low fat diet with or without orlistat . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the present study , expression and selected activities of urokinase type plasminogen activator ( uPA ) , matrix metalloproteinases ( MMPs ) , their inhibitors ( plasminogen activator inhibitor 1 ( PAI 1 ) and tissue inhibitors of metalloproteinases ( TIMPs ) ) were examined in bovine oviducts by RT PCR , ribonuclease protection assay and activity assays . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Finally , activated protein C can reduce plasminogen activator inhibitor 1 , thereby stimulating fibrinolysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma plasminogen activator inhibitor 1 activity in normoglycemic hypertriglyceridemic north Asian Indian subjects : a preliminary case control study . ^^^ BACKGROUND : Recent evidence suggests that increased activity of plasma plasminogen activator inhibitor 1 , an important component of the insulin resistance syndrome , plays a crucial role in the pathogenesis of atherosclerosis . ^^^ METHODS AND RESULTS : In this case control study , relationships between plasma plasminogen activator inhibitor 1 activity , serum triglyceride levels and hyperinsulinemia were explored in 40 non diabetic patients with primary hypertriglyceridemia ( Group 1 ) and 40 non diabetic normotriglyceridemic controls ( Group 2 ) matched for potential confounders like smoking and physical activity . ^^^ Mean plasma plasminogen activator inhibitor 1 activity in Group 1 ( 9 . 8+ / 8 . 4 IU ) was higher than in Group 2 ( 7 . 0+ / 7 . 7 IU ) , though the difference was not significant ( p > 0 . 05 ) . ^^^ However , when only subjects with elevated levels of plasma plasminogen activator inhibitor 1 activity were taken into account , mean values were significantly higher in Group 1 ( p < 0 . 05 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We also found that the neurotropic actions of angiotensin 2 are mediated by plasminogen activator inhibitor 1 . ^^^ Evidence for this includes 1 ) angiotensin 2 stimulated neuronal plasminogen activator inhibitor 1 gene expression , 2 ) potent neurotropic action of exogenous plasminogen activator inhibitor 1 , and 3 ) inhibitory neurotropic effect of angiotensin 2 by antisense oligonucleotide mediated depletion of plasminogen activator inhibitor 1 . ^^^ Finally , we found that the neurotropic action of plasminogen activator inhibitor 1 is not blocked by either angiotensin type 1 receptor antagonist or inhibitors of PI3K or p 70 ( S 6 ) kinase , indicating that the plasminogen activator inhibitor 1 step is downstream from the p 70 ( S 6 ) kinase . ^^^ These observations demonstrate that angiotensin 2 is a neurotropic hormone that engages a distinct PI3K p 70 ( S 6 ) kinase plasminogen activator inhibitor 1 signaling pathway for this action . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Its presence correlates with an upregulation of plasminogen activator inhibitor 1 and tissue factor in alveolar cells surrounding the lesion area . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
But metformin has fibrinolytic features by means of diminished plasminogen activator inhibitor 1 activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Increased levels of fibrinogen and plasminogen activator inhibitor 1 favor both thrombosis and defective dissolution of clots once formed . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Disruption of the plasminogen activator inhibitor 1 gene reduces the adiposity and improves the metabolic profile of genetically obese and diabetic ob / ob mice . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Possible role of the 4G / 5G polymorphism of the plasminogen activator inhibitor 1 gene in the development of asthma . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Both latent and active TGF beta were quantified directly in the blood plasma using a bioassay with mink lung epithelial cells transfected with a plasminogen activator inhibitor 1 promotor luciferase construct . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In 82 subjects ( 47 free of clinical signs of CAD and in 35 survivors of AMI ) , measurements of body mass index ( BMI ) , lipoproteins , glucose , insulin , plasminogen activator inhibitor 1 , tissue type plasminogen activator ( t PA ) , euglobulin clot lysis time , fibrinogen , and platelet count were performed twice in the cold months ( December and March ) and twice in the warm months ( June and September ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
INTRODUCTION : Given that nonvalvular atrial fibrillation ( AF ) associated stroke can be either cardioembolic or atherothrombotic , we investigated the relationships between nonvalvular AF and hemostatic factors reflecting intrinsic thrombogenic and atherogenic potentials ( tissue plasminogen activator [ t PA ] antigen , plasminogen activator inhibitor 1 , and factor 8 activity ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Both groups showed reduced concentrations of total cholesterol , low density lipoprotein cholesterol , tissue plasminogen activator , plasminogen activator inhibitor 1 , antithrombin 3 , and protein S , whereas protein C was increased after 12 months of treatment . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Dietary vitamin E and % energy from fat had positive effects , whereas plasma plasminogen activator inhibitor 1 , fibrinogen , body weight and serum ferritin had negative effects on HDL and total to HDL cholesterol . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Synthesis and in vitro evaluation of a series of diketopiperazine inhibitors of plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
When injected s . c . into athymic mice , these clones exhibited attenuated growth rates and angiogenesis and decreased levels of plasminogen activator inhibitor 1 mRNA as compared with tumors formed by sham transfected cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
After dietary intervention decreases in blood pressure , low density lipoprotein to high density lipoprotein cholesterol ratio , triglycerides , fibrinogen , plasminogen activator inhibitor 1 , and an increase in tissue type plasminogen activator activity levels were observed . ^^^ Changes in IMT were associated independently and significantly with changes in body mass index , low density lipoprotein to high density lipoprotein cholesterol ratio , and plasminogen activator inhibitor 1 antigen . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We observed a preferential expression of MAGE A in patients at a higher risk of recurrence : those harboring tumors with high levels of the protease urokinase type plasminogen activator and its inhibitor plasminogen activator inhibitor 1 , high score of the Ki 67 proliferation antigen , and lesser degree of differentiation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 levels are decreased by pravastatin , are not affected by atorvastatin , and are significantly increased by lovastatin and simvastatin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Furthermore , adhesion to vitronectin and fibronectin was reduced by compounds that interfere with integrin function , such as EDTA , anti integrin antibodies , or by antibodies that interfere with the binding of pro uPA to uPAR , soluble uPAR , soluble vitronectin , phosphatidylinositol specific phospholipase C , as well as plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Transient transfection of a transformed human mesangial cell line with a CTGF V 5 epitope fusion protein markedly increased fibronectin and plasminogen activator inhibitor 1 synthesis in cultures maintained in normal glucose ( 4 mM ) conditions ; a CTGF antisense construct reduced the elevated synthesis of these proteins in high glucose ( 30 mM ) cultures . ^^^ Nevertheless CTGF expression in diabetic kidneys is likely to be a key event in the development of glomerulosclerosis by affecting both matrix synthesis and , potentially through plasminogen activator inhibitor 1 , its turnover . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The concentrations of tissue plasminogen activator and plasminogen activator inhibitor 1 were significantly reduced after 12 months of HRT . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Highly significant quantitative increases in urokinase PA ( uPA ) , urokinase receptor ( uPAR ) and plasminogen activator inhibitor 1 were detected in acute multiple sclerosis lesions ( P < 0 . 0001 ) and in uPAR in normal appearing white matter ( P < 0 . 0001 ) compared with control tissue . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This effect may be mediated by the suppression of the usual cortisol response to surgery , which results in increased circulating plasminogen activator inhibitor 1 with consequent adverse effects on fibrinolysis . ^^^ Blood samples were collected at 0 , 2 , 4 , 6 , 12 and 24 h , and 2 , 3 and 5 days and analysed for cortisol , plasminogen activator inhibitor 1 antigen , interleukin 6 and beta thromboglobulin . ^^^ There were no significant changes from control values in either group of patients in circulating cortisol , plasminogen activator inhibitor 1 and beta thrombogobulin ( a marker for platelet degranulation ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Orthotopic / isogeneic rat lung transplantation triggers Egr 1 expression and nuclear DNA binding activity corresponding to Egr 1 , which leads to increased expression of downstream target genes such as interleukin 1b , tissue factor , and plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Urokinase type plasminogen activator , tissue type plasminogen activator , urokinase type plasminogen activator receptor , and plasminogen activator inhibitor 1 expression were studied . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Leptin is one of a number of proteins secreted from white adipocytes , which include angiotensinogen , adipsin , acylation stimulating protein , adiponectin , retinol binding protein , tumour neorosis factor a , interleukin 6 , plasminogen activator inhibitor 1 and tissue factor . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Compared with placebo , estrogen tended to decrease tissue factor antigen and increase tissue factor activity levels by 7 + / 46 % and 5 + / 34 % , respectively ( p = 0 . 321 and p = 0 . 117 , respectively ) and lower plasminogen activator inhibitor 1 levels by 16 + / 31 % ( p = 0 . 043 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Adhesion molecules [ E selectin , intracellular adhesion molecule 1 ( ICAM 1 ) , and vascular cell adhesion molecule 1 ] , von Willebrand factor , total nitric oxide ( NO ) , endothelin 1 , tissue plasminogen activator , and plasminogen activator inhibitor 1 were measured in 43 type 2 diabetic subjects with hemoglobin A1c of 9 . 0 % or more at baseline ( compared with 21 healthy controls ) who after 20 wk had been randomized to either improved ( IC ) or usual ( UC ) glycemic control . ^^^ Body mass index in the diabetic patients was the only independent predictor of E selectin ( P = 0 . 007 ) , ICAM 1 ( P = 0 . 01 ) , and NO ( P = 0 . 008 ) concentrations , but not vascular cell adhesion molecule 1 , plasminogen activator inhibitor 1 , or tissue plasminogen activator ( all P > 0 . 05 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Angiotensin as inducer of plasminogen activator inhibitor 1 and fibrosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Our data indicate that TGFbeta dose responsively and reversibly inhibits cell growth in ED 27 cells and induces classic TGFbeta response genes , fibronectin and plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Number and size of lung metastases were significantly increased . cDNA expression array analysis of TGF beta 1 transduced fibroblasts embedded in type 1 collagen and of TGF beta 1 transduced melanoma cells demonstrated induction of types 15 , 18 , and 6 collagens , tenascin , plasminogen activator inhibitor 1 , vascular endothelial growth factor , cysteine rich fibroblast growth factor receptor 1 , and platelet derived growth factor receptor beta , which could be linked to promotion of growth and survival in melanoma . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Elevation of plasminogen activator inhibitor 1 , lipoprotein ( a ) , and alpha 2 antiplasmin was present in 23 , 10 , and 4 cases , respectively . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We studied binding of ( 3 ) H labeled hydrophobic hormones ( estradiol , progesterone , testosterone , cortisol , aldosterone , and all trans retinoic acid ) to the inhibitory serpins antithrombin 3 , heparin cofactor 2 , plasminogen activator inhibitor 1 , and protein C inhibitor ( PCI ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Moreover , rAN 2 treatment of HUVECs restored plasmin generation impaired by plasminogen activator inhibitor 1 or homocysteine pretreatment . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To identify functional interactions between aHSPGs and heparin binding protease inhibitors in the follicle , we have coordinately localized aHSPGs , antithrombin 3 , protease nexin 1 , and plasminogen activator inhibitor 1 in the rat ovary during natural and gonadotropin stimulated cycles . ^^^ Anticoagulant HSPGs were colocalized with protease nexin 1 in follicles from the early antral stage until ovulation , with antithrombin 3 in the preovulatory stage and after ovulation , and with plasminogen activator inhibitor 1 in the corpus luteum . ^^^ These data demonstrate that aHSPGs are critically expressed in the ovary to interact sequentially with protease nexin 1 , antithrombin 3 , and plasminogen activator inhibitor 1 during the cycle . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
IGFBP 3 and nuclear localization signal mutant IGFBP 3 stimulated the activation of the plasminogen activator inhibitor 1 promoter but was not additive with TGF beta , suggesting that this end point is not a direct marker of the IGFBP 3 effect on cell proliferation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Other parameters disclosed no statistical significance between patients and control group except for elevated fibrinogen and plasminogen activator inhibitor 1 levels in the patient group ( P < 0 . 003 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
RESULTS : Antithrombin levels were significantly lower whereas fibrinogen and plasminogen activator inhibitor 1 levels were higher in the unstable patients than in the stable patients . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The importance of this finding is that the peptide prevented the polymerization of Z alpha ( 1 ) antitrypsin and did not significantly anneal to other proteins ( such as antithrombin , alpha ( 1 ) antichymotrypsin , and plasminogen activator inhibitor 1 ) with a similar tertiary structure . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
D dimer , plasmin alpha 2 antiplasmin complex , plasminogen activator inhibitor 1 , protein C , protein S , and tissue plasminogen activator ) , totaling more than 15 , 000 data points . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Cytokines such as tumor necrosis factor alpha , interferon gamma , and interleukin 10 were also significantly decreased by EPA ( P < 0 . 05 ) , as were factors causing vascular endothelial damage such as thrombomodulin and plasminogen activator inhibitor 1 ( P < 0 . 05 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In addition , transgenic rabbits showed delayed fibrinolytic activity accompanied by increased plasma plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 induction after experimental intracerebral hemorrhage . ^^^ Plasminogen activator inhibitor 1 is one of the serine protease inhibitors , or serpins . ^^^ The purpose of this study was to determine whether plasminogen activator inhibitor 1 and tissue type plasminogen activator are upregulated after intracerebral hemorrhage and the role that thrombin plays in that induction . ^^^ Plasminogen activator inhibitor 1 protein levels were upregulated after intracerebral hemorrhage . ^^^ Brain plasminogen activator inhibitor 1 content also increased after thrombin infusion in a dose dependent manner . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This activity was inhibited by plasminogen activator inhibitor 1 or antibodies to uPA but not tPA . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The three members of the serpin family , corticosteroid binding globulin , alpha 1 antitrypsin , and C 1 inhibitor are secreted apically from Madin Darby canine kidney ( MDCK ) cells , whereas two homologous family members , antithrombin and plasminogen activator inhibitor 1 , are secreted in a nonpolarized fashion . cDNAs coding for chimeras composed of complementary portions of an apically targeted serpin and a nonsorted serpin were generated , expressed in MDCK cells , and the ratio between apical and basolateral secretion was analyzed . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The effect of these polymers on the biological response of TGFbeta 1 was assessed using mink lung epithelial cells transfected with a plasminogen activator inhibitor 1 promoter luciferase construct ( PAI / Luc ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A significant increase in mRNA expression in response to 17 beta estradiol was observed for the following three genes : aldose reductase ( 3 . 4 fold ) , caspase homologue alpha protein ( 4 . 2 fold ) , and plasminogen activator inhibitor 1 intron e ( 2 . 3 fold ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This particular dyslipidaemia , along with hyperinsulinaemia , induces expression of plasminogen activator inhibitor 1 , contributing to a prothrombotic state . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We identified several previously characterized angiogenic markers , including the alpha ( 5 ) chain of the alpha ( 5 ) beta 3 integrin and plasminogen activator inhibitor 1 , suggesting overlap in gene expression between tube forming cells in vitro and in vivo . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Measures of glucose control , insulin resistance , and CVRF ( blood pressure , lipids , plasminogen activator inhibitor 1 , C reactive protein , fibrinogen , and small dense LDL ) were assessed both before and after therapy . ^^^ Metformin did not induce significant changes in blood pressure , LDL cholesterol , LDL size , HDL cholesterol , triglycerides , or plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Decorin suppresses transforming growth factor beta induced expression of plasminogen activator inhibitor 1 in human mesangial cells through a mechanism that involves Ca2+ dependent phosphorylation of Smad 2 at serine 240 . ^^^ One of the main target cells for TGFbeta in the kidney are glomerular mesangial cells , which respond by increasing expression of ECM proteins , such as collagens , laminin and fibronectin , while suppressing the expression of ECM degrading proteases and increasing the synthesis of ECM protease inhibitors , including plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
After four days of high flow , urokinase was increased and plasminogen activator inhibitor 1 was decreased in the intima . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In total , 22 functional and immunologic assays were applied to plasma obtained from domestic pigs , and the following blood coagulation and fibrinolysis variables were measured : prothrombin time , activated partial thromboplastin time , tissue factor , tissue factor pathway inhibitor , factor 7 , protein C , protein S , prothrombin fragment 1+2 , antithrombin , thrombin antithrombin complexes , fibrinogen , soluble fibrin , urokinase type plasminogen activator , plasmin inhibitor , plasminogen activator inhibitor 1 , and D dimer . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The transcriptional induction of plasminogen activator inhibitor 1 and p 21 ( WAF1 / CIP1 ) by TGF beta were detected in all HCC cell lines , implying that the molecular integrity of the TGF beta receptors might be intact . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
These effects were accompanied by a decreased renal expression of transforming growth factor beta 1 , plasminogen activator inhibitor 1 , and several other extracellular matrix proteins compared with vehicle treated SHR SP . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : In 86 patients , pre dialysis serum HGF , soluble endothelial markers such as thrombomodulin ( TM ) , von Willebrand factor and plasminogen activator inhibitor 1 and hepatitis B and C markers were measured by ELISAs . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
It has been reported that the increase of plasminogen activator inhibitor 1 activity immediately after elective coronary angioplasty is related to subsequent clinical recurrence in patients with chronic coronary artery disease . ^^^ The aims of our study were to evaluate the behavior of plasminogen activator inhibitor 1 and D Dimer after revascularization in acute myocardial infarction patients treated with angioplasty and stenting and if this behavior is predictive of subsequent clinical recurrence . ^^^ D Dimer and plasminogen activator inhibitor 1 activity were evaluated in two groups of patients . ^^^ D Dimer and plasminogen activator inhibitor 1 baseline levels were significantly higher in group 1 than in group 2 ( P < 0 . 0005 and P < 0 . 05 , respectively ) . ^^^ The percentage of group 2 patients in whom no decrease of plasminogen activator inhibitor 1 was observed after angioplasty was significantly higher ( 83 % ) among those with subsequent recurrence than among those with no recurrence ( 38 % , P < 0 . 05 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Aboriginal people had significantly higher rates of smoking , glucose intolerance , obesity , abdominal obesity , and substantially higher concentrations of fibrinogen , and plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Id 1 was found to mediate the TGF beta / ALK1 induced ( and Smad dependent ) migration , while induction of plasminogen activator inhibitor 1 by activated ALK 5 may contribute to the TGF beta induced maturation of blood vessels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : Fibrinolytic measurements included euglobulin clot lysis time ( ELT ) , fibrinogen , plasminogen activator inhibitor 1 , and tissue type plasminogen activator . ^^^ In the women ' s groups only , we observed a trend toward increased plasminogen activator inhibitor 1 among the women with DM . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Prognostic significance of plasminogen activator inhibitor 1 in breast cancer , with special emphasis on locoregional recurrence free survival . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Serum hormones , lipid profile , homocysteine , vitamin B ( 12 ) , folate , fibrinogen , uric acid , and plasminogen activator inhibitor 1 concentrations were measured . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
IFN gamma / LPS dependent induction of IL 6 , IL 1beta , TNF alpha , inducible NO synthase , and plasminogen activator inhibitor 1 mRNAs was variably impaired , while IL 12 p 40 , RANTES and macrophage inflammatory protein 1beta mRNAs were up regulated in the absence of C / EBPbeta . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Estimated insulin resistance and plasminogen activator inhibitor 1 levels were not increased in relatives . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
RESULTS : In contrast to the mere detection of disseminated tumor cells at primary surgery , the additional evidence of u PAR on these cells correlated significantly with pathologic T stage ( P = . 0474 ) and the expression of u PAR ( P = . 0093 ) and plasminogen activator inhibitor 1 ( P = . 0145 ) in the primary tumor ( immunohistochemistry , chi ( 2 ) ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Contrast agents did not affect plasminogen activator inhibitor 1 or alpha ( 2 ) antiplasmin function . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fibrinolytic disorders were investigated for tissue plasminogen activator , plasminogen activator inhibitor 1 , plasminogen activator inhibitor 1 to tissue plasminogen activator ratio , lipoprotein ( a ) , and plasminogen . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Serum determinations of antigen of tissue plasminogen activator and plasminogen activator inhibitor 1 were done using enzyme linked immunosorbent assays . ^^^ The greatest difference was observed 8 hours after surgery for the plasminogen activator inhibitor 1 marker , ( 28 . 12 with compression versus 22 . 07 ng / mL without ) ; however , this result was not statistically significant . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Angiotensin 2 increases the production and secretion of plasminogen activator inhibitor 1 , while angiotensin converting enzyme ( ACE ) contributes to reduced production of tissue plasminogen activator and endothelial nitric oxide synthesis by bradykinin degradation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The latter process is inhibited by plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
After coronary interventions there is an enhanced plasminogen activator inhibitor 1 synthesis in diabetic patients compared to controls . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
PROBLEM : To investigate whether endometriotic stromal cells release the urokinase plasminogen activator , soluble urokinase plasminogen activator receptor and plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Hoffstedt et al . ( 2002 ) The common 675 4G / 5G polymorphism in the plasminogen activator inhibitor 1 gene is strongly associated with obesity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The polymorphisms studied were : G1691A in Factor 5 ( Factor 5 Leiden ; FVL ) , prothrombin G20210A , methylenetetrahydrofolate reductase ( MTHFR ) C677T , plasminogen activator inhibitor 1 4G / 5G and the platelet collagen receptor alpha2beta1 C807T . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We also identified three novel SREBP 1c transcriptional targets in adipocytes , which were confirmed by run on assays : plasminogen activator inhibitor 1 , CCAAT / enhancer binding protein delta ( C / EBPdelta ) , and C / EBPbeta . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The functional consequences of alternative splicing for transcriptional activation by CLOCK : BMAL 2 heterodimers were assessed using luciferase reporter gene constructs that contained one of three diurnally regulated promoters , namely , those of the mouse period 1 , mouse vasopressin , and human plasminogen activator inhibitor 1 genes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Subjects with the highest tertile of steady state plasma glucose showed a significantly higher body mass index , blood pressure , fasting plasma triglyceride levels , plasminogen activator inhibitor 1 and lower HDL cholesterol , i . e . an insulin resistance pattern . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
At the onset of thrombotic thrombocytopenic purpura and hemolytic uremic syndrome , the levels of interleukin 8 , thrombomodulin , and plasminogen activator inhibitor 1 were all markedly increased . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the same study , plasminogen activator inhibitor 1 concentrations were reduced by 58 % after the low GI diet . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
DESIGN : Endothelial cell cultures from human female coronary arteries were used to evaluate the effect of progestin addition to E ( 2 ) on the production of the following endothelial markers : prostacyclin , endothelin , plasminogen activator inhibitor 1 , E selectin , intercellular adhesion molecule 1 , monocyte chemoattractant protein 1 ( MCP 1 ) , and the precursor of matrix metalloproteinase 1 ( pro MMP 1 ) . ^^^ RESULTS : E ( 2 ) induced a significant increase of endothelial prostacyclin production and was able to significantly decrease the synthesis of endothelin , plasminogen activator inhibitor 1 , E selectin , and intercellular adhesion molecule 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma melatonin , tissue plasminogen activator antigen , and plasminogen activator inhibitor 1 antigen were measured at 4 h intervals over a 24 h period . ^^^ The peak times of tissue plasminogen activator and plasminogen activator inhibitor 1 antigens were practically identical in controls and cirrhotic patients , irrespective of Child Pugh class ( calculated peak at times 6 : 52 , 6 : 56 , and 7 : 20 for the inhibitor in controls and Child Pugh class A and classes B / C patients , respectively ; p = ns ) , whereas the peak of melatonin was delayed in classes B / C patients ( at times 2 : 08 , 1 : 56 , and 4 : 00 , respectively ; p < 0 . 05 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tax inhibits TGF beta induced plasminogen activator inhibitor 1 expression and Smad 2 phosphorylation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Intact female mice tend to show greater levels of striatal glial fibrillary acidic protein and decreased levels of plasminogen activator inhibitor 1 compared with males . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
As for cytokines and vascular endothelial cell function markers , interleukin 6 and plasminogen activator inhibitor 1 significantly decreased . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This review explores the hypothesis that aldosterone causes injury and fibrosis , in part , through effects on plasminogen activator inhibitor 1 , the major physiological inhibitor of plasminogen activators in vivo . ^^^ Aldosterone interacts with angiotensin 2 to increase plasminogen activator inhibitor 1 expression in vitro and in vivo . ^^^ Plasminogen activator inhibitor 1 , by inhibiting the production of plasmin from plasminogen , tips the balance in favor of extracellular matrix accumulation and promotes fibrosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
More specific substrates for these proteases were derived from the reactive site loop of plasminogen activator inhibitor 1 , proteinase inhibitors 6 and 9 , and from the related viral cytokine response modifier A ( CrmA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The clinical course of the patients was recorded and inflammatory and fibrinolytic markers ( C reactive protein , fibrinogen , interleukin 6 , plasminogen activator inhibitor 1 , prothrombin time , activated partial thromboplastin time , platelets and white blood cell counts ) were determined before surgery , 24 , 48 and 72 hours thereafter , and at hospital discharge . ^^^ Plasminogen activator inhibitor 1 , prothrombin time , and activated partial thromboplastin time increased from few hours postoperatively and returned to normal before discharge . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Recently it has been demonstrated that the adipocyte itself is able to produce plasminogen activator inhibitor 1 , possibly explaining the high levels found in obesity . ^^^ In contrast , plasminogen activator inhibitor 1 has been found to correlate with all components of the insulin resistance syndrome , and can be considered as a true component of this metabolic syndrome . ^^^ In contrast , both modest and substantial weight loss have been found to significantly reduce plasminogen activator inhibitor 1 levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In this study we determined the in vitro effects of polysulfated glycosaminoglycan ( PSGAG ) and the glucocorticoid triamcinolone acetonid ( TA ) on the IL 1 altered expression and activity of matrix metalloproteinases ( MMP 1 , MMP 3 ) , tissue inhibitor of metalloproteinases 1 , the plasminogen activators tPA and uPA and plasminogen activator inhibitor 1 by articular chondrocytes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Compared with controls , PPH patients had elevated plasma levels of tissue type plasminogen activator ( 15 . 6 + / 9 . 9 versus 5 . 5 + / 3 ng / ml ) and plasminogen activator inhibitor 1 ( 27 . 8 + / 23 versus 16 . 4 + / 12 ng / ml ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
One week smoking cessation significantly increased serum high density lipoprotein ( HDL ) cholesterol levels ( P < 0 . 05 ) , and significantly decreased serum lipoprotein ( a ) levels ( P < 0 . 01 ) and plasma plasminogen activator inhibitor 1 levels ( P < 0 . 05 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In parallel , an impairment of the fibrinolytic system was demonstrated by an increase in plasma levels and arterial secretion of plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Novel inhibitors of plasminogen activator inhibitor 1 : development of new templates from diketopiperazines . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Both plasminogen activator inhibitor 1 and tissue inhibitor of metalloproteinase blocked collagen dissolution , demonstrating the requirement of both plasminogen activation and matrix metalloproteinase activity for degradation . ^^^ The activation of matrix metalloproteinase 13 in normal keratinocytes was prevented by plasminogen activator inhibitor 1 and aprotinin but not by tissue inhibitor of metalloproteinase 1 and 2 , suggesting that plasmin activates matrix metalloproteinase 13 directly . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Potentially valuable novel drug targets include downstream mediators of angiotensin 2 such as transforming growth factor b , plasminogen activator inhibitor 1 , and endothelin 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The levels of thrombomodulin , plasminogen activator inhibitor 1 , and cyclic GMP were measured before and after TBI . ^^^ At both times , the thrombomodulin and plasminogen activator inhibitor 1 levels were within the normal range in all patients from the two groups , without any significant differences between the groups . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
No significant changes were seen in plasminogen activator inhibitor 1 levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We here report that the mortality due to an experimental acute myocardial infarction ( AMI ) was markedly increased in mice deficient in alpha 2 antiplasmin ( alpha 2 AP ( / ) mice ) but not in mice deficient in other components acting in fibrinolysis ( tissue type PA , urokinase type PA , or plasminogen activator inhibitor 1 ) even if the infarct area in alpha 2 AP ( / ) mice was not different from those in the other mice . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The antigen level for antithrombin , plasminogen activator inhibitor 1 , and heparin cofactor 2 , and the plasma activity of antithrombin and plasminogen were determined by using immunologic and chromogenic assays . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A 2 . 2 A resolution crystal structure of the stable form ( PDB code , ) showed that the reactive site loop is inserted into an A beta sheet , as in the latent plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
MATERIAL AND METHODS : Among 113 primary isolated coronary artery bypass patients , CRP was determined preoperatively and fibrinogen , interleukine 6 , plasminogen activator inhibitor 1 , prothrombin time , activated partial thromboplastin time , platelets and white blood cells count measured before surgery , 24 , 48 and 72h thereafter and at hospital discharge . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fibrinolysis , which is strictly regulated by plasminogen activator inhibitor 1 ( PAL 1 ) and tissue type plasminogen activator ( tPA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
It has been reported that adipocytes secrete a variety of proteins , including tumor necrosis factor alpha , resistin , plasminogen activator inhibitor 1 , and adiponectin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Secondary outcomes include measures of islet beta cell function , insulin sensitivity , dyslipidemia , changes in urinary albumin excretion , plasminogen activator inhibitor 1 antigen , fibrinogen , and C reactive protein . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Associated with each of these conditions is angiotensin 2 mediated stimulation of macrophages , platelet aggregation , plasminogen activator inhibitor 1 , endothelial dysfunction , vascular smooth muscle cell proliferation and migration , apoptosis , leukocyte recruitment , fibrogenesis and thrombosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We measured and compared pre and post eradication blood sugar , lipid profiles ( total cholesterol , high density lipoprotein cholesterol , low density lipoprotein cholesterol , and triglyceride ) and fibrinolytic profiles ( tissue plasminogen activator , plasminogen activator inhibitor 1 , fibrinogen , and D dimer levels ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Thrombin antithrombin complex and soluble fibrin are reflected to hypercoagulable state , thrombomodulin to vascular endothelial cell injuries , and plasminogen activator inhibitor 1 to hypofibrinolytic state . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
MEASUREMENTS AND MAIN RESULTS : The MOF group had fibrinolysis abnormality , as indicated by increased plasminogen activator inhibitor 1 level . ^^^ In addition , both polymorphonuclear elastase and polymorphonuclear fibrinogen degradation products were significantly positively correlated with thrombomodulin in the MOF group , but no such positive correlation was observed between interleukin 6 or plasminogen activator inhibitor 1 and thrombomodulin . ^^^ In the non MOF group , on the other hand , thrombomodulin exhibited no significant positive correlation with polymorphonuclear elastase , polymorphonuclear fibrinogen degradation products , interleukin 6 , or plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Hormone receptor status , Ki 67 , S phase fraction , DNA ploidy , HER 2 / neu , p 53 , epidermal growth factor receptor , urokinase type plasminogen activator , plasminogen activator inhibitor 1 , bone marrow micrometastases as well as patient age , menopausal status , tumor site , tumor size , histologic type , tumor grade , carcinoma in situ , multifocality , and lymph vascular invasion ( LVI ) were studied to predict axillary lymph node status . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
When Smad 4 was expressed in Smad 4 null breast carcinoma cell line MDA MB 468 using the recombinant adenovirus , TGF beta signaling was restored as determined by TGF beta dependent activity of plasminogen activator inhibitor 1 promoter and p 21 expression . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
There is a widely held belief that they also enhance endogenous fibrinolysis ; however , recent studies of tissue plasminogen activator ( the primary activator of fibrinolysis ) and plasminogen activator inhibitor 1 ( the primary inhibitor of fibrinolysis ) failed to confirm this . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This review summarizes the current literature regarding the role of the Sp 1 protein family in regulating the response to steroid hormones of genes for tissue factor , plasminogen activator inhibitor 1 , insulin like growth factor binding protein 1 , uteroglobin , and uteroferrin in the endometrium . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Molecular genetic testing was performed for factor 5 Leiden , prothrombin promoter G20210A , methylenetetrahydrofolate reductase C677T , plasminogen activator inhibitor 1 4G / 4G , and platelet glycoprotein IIb / IIIa A1 / A2 or A2 / A2 mutations . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 antigen declined in both oral CEE and transdermal estradiol users , but did not achieve statistical significance . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
No statistically significant changes were found in the levels of coagulation factors 5 , von Willebrand factor , and activated factor 7 ; nor were any changes observed for activated protein C resistance , coagulation inhibitors protein C , protein S , or plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
After 6 months of HRT , significant decreases in activity of antithrombin 3 and protein C and levels of plasminogen activator inhibitor 1 antigen , tissue type plasminogen activator antigen , and euglobulin clot lysis time and a significant increase in D dimer level were found compared with placebo . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
To identify small molecular weight compounds with TGF beta like activities , high throughput screening was performed using mink lung epithelial cells stably transfected with a TGF beta responsive plasminogen activator inhibitor 1 promoter / luciferase construct . ^^^ Biaryl hydroxamate compounds were identified that demonstrated TGF beta like activities . 7 [ 4 ( 4 cyanophenyl ) phenoxy ] heptanohydroxamic acid ( A 161906 ) demonstrated complete TGF beta like agonist activity in the plasminogen activator inhibitor 1 / luciferase construct . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In particular , elevated expression of full length TGN 38 led to increased secretion of a 48 kDa glycoprotein identified as plasminogen activator inhibitor 1 . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 and C reactive protein also declined significantly . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We had earlier shown that Smad 3 restituted JAR cells had also restored TGF beta response of plasminogen activator inhibitor 1 upregulation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Smad 3 dependent induction of plasminogen activator inhibitor 1 in astrocytes mediates neuroprotective activity of transforming growth factor beta 1 against NMDA induced necrosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 expression is regulated by the inflammatory mediators interleukin 1alpha , tumor necrosis factor alpha , transforming growth factor beta and oncostatin M in human cardiac myocytes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The mutations / polymorphisms studied included Factor 5 Leiden , prothrombin variant G20210A , beta fibrinogen 448 ( G / A ) , endothelial protein C receptor ( 23 base pair insertion ) , methyl tetrahydrofolate reductase 677 ( C / T ) , platelet glycoprotein IIIa PlA1 / A2 , plasminogen activator inhibitor 1 4G / 5G , angiotensin 2 type 1 receptor ( A / C ) , hemochromatosis gene 282 ( G / A ) , nitric oxide synthase ( NOS ) ( 3 forms : eNOS , eNOS 3 , eNOS 4 ) , p 22 phox of NADPH oxidase C242T , and angiotensin converting enzyme insertion / deletion polymorphism . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Using two different methods of computational cluster analysis , we identified a subset of six matricellular proteins ( eg , osteopontin and plasminogen activator inhibitor 1 ) that are coordinately upregulated by Ang 2 via an ERK / p38 dependent pathway . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Downstream effects of statins included inhibition of plasminogen activator inhibitor 1 and vascular endothelial growth factor A mRNA levels in endothelial cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Other biomarkers such as resistin , fibrinogen , and plasminogen activator inhibitor 1 were not different between groups . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Western blot analyses using antibodies against hepatocyte growth factor , hepatocyte growth factor receptor , phosphotyrosine , hepatocyte growth factor activator , urokinase type plasminogen activator receptor , urokinase type plasminogen activator , plasminogen activator inhibitor 1 , fibrinogen and plasmin were performed on membrane enriched fractions from the frozen tissue , as was collagen zymography for matrix metalloproteinase 2 and matrix metalloproteinase 9 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Decreased plasminogen activator inhibitor 1 secretion in hypoxic corneal epithelial cells is associated with increased urokinase plasminogen activator activity . ^^^ Relative changes in mRNA levels of plasminogen activator , receptor , and plasminogen activator inhibitor 1 were determined using a cDNA expression array , chemiluminescence , and densitometry . ^^^ In contrast decreases in mRNA and secreted plasminogen activator inhibitor 1 protein were observed in hypoxic cells . ^^^ The formation of plasminogen activator / receptor / plasminogen activator inhibitor 1 complex at the cell surface was not inhibited by hypoxia . ^^^ However , in hypoxic cells less plasminogen activator inhibitor 1 was associated with receptor . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma tissue plasminogen activator , plasminogen activator inhibitor 1 , plasminogen , alpha ( 2 ) antiplasmin , alpha ( 2 ) macroglubulin , D dimers , euglobulin lysis time , and fibrinogen were measured on each sample . ^^^ Adolescents had significantly decreased tissue plasminogen activator antigen levels and increased plasminogen activator inhibitor 1 activity levels after venous occlusion , resulting in significantly prolonged euglobulin lysis times . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Of interest , after stimulating the fibrinolytic system with the DSE test , plasminogen activator inhibitor 1 activity was significantly higher in patients with necrotic / stunned myocardium than in patients with resting normal wall motion ( P = 0 . 03 ) , whereas tissue type plasminogen activator activity after the DSE test was significantly lower in patients with stunned / necrotic myocardium than in patients with normal wall motion ( P = 0 . 001 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Activated protein C also facilitates clot lysis by inhibiting plasminogen activator inhibitor 1 , a process that is accelerated markedly by vitronectin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The proteolytic activity of APC in plasma is slowly inhibited by three serpins : protein C inhibitor , plasminogen activator inhibitor 1 , and alpha ( 1 ) antitrypsin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
For example , TZDs have been shown to lower blood levels of plasminogen activator inhibitor 1 , a prothrombotic substance , in patients with diabetes or insulin resistance . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Thrombogenic factors included d dimer , fibrinogen , plasminogen activator inhibitor 1 , von Willebrand factor , factor 7 , and factor VIIa . ^^^ In comparison with nonhypertensive patients , those with hypertension had higher levels of d dimer ( 607 versus 453 mg / L , P < 0 . 001 ) , fibrinogen ( 3 . 64 versus 3 . 43 g / L , P < 0 . 001 ) , plasminogen activator inhibitor 1 ( 29 . 7 versus 27 . 3 ng / mL , P=0 . 01 ) , von Willebrand factor ( 159 versus 141 IU / dL ; P < 0 . 001 ) , and higher levels of inflammatory markers ( hsCRP and SAA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The present study was designed to analyse the role of the factor 5 Leiden and the prothrombin G20210A mutations and plasminogen activator inhibitor 1 4G / 5G polymorphism on the thrombotic risk of patients with Behcet ' s disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The aim of this study was to investigate systemic coagulation activity , fibrinolytic capacity , and platelet activation in IE patients with and without embolic events by measuring the plasma levels of prothrombin fragment 1 + 2 , thrombin antithrombin 3 complex , plasminogen activator inhibitor 1 , beta thromboglobulin , and platelet factor 4 . ^^^ Embolic patients also had higher plasminogen activator inhibitor 1 levels than both nonembolic patients and healthy subjects ( 14 . 4 + / 6 . 4 vs 8 . 6 + / 5 . 9 and 5 . 4 + / 4 . 3 ng / ml , p = 0 . 002 , respectively ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
DESIGN : We performed a placebo controlled 2 year trial among 158 healthy siblings of patients with premature atherosclerotic disease to determine the effect of daily folic acid ( 5 mg ) plus vitamin B 6 ( 250 mg ) treatment as compared with placebo medication ( n = 80 ) on markers of endothelial function ( urinary albumin to creatinine ratio and plasma concentrations of soluble E selectin , soluble vascular cell adhesion molecule 1 , von Willebrand factor , tissue type plasminogen activator and plasminogen activator inhibitor 1 ) and inflammation ( C reactive protein ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
ROS mimic the stimulatory effects of HG and upregulate transforming growth factor beta 1 , plasminogen activator inhibitor 1 , and extracellular matrix ( ECM ) proteins by glomerular mesangial cells , thus leading to mesangial expansion . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
These agents , at nanomolar concentrations , increase the expression of TGF beta dependent genes , such as those for plasminogen activator inhibitor 1 and the type 2 TGF beta receptor , and they synergize with TGF beta in this regard . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Intraventricular hemorrhage in a full term neonate associated with sinus venous thrombosis and homozygosity for the plasminogen activator inhibitor 1 4G / 4G polymorphism . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
At the end of each experiment , blood pressure and heart rate were recorded , glomerular matrix expansion was scored histologically , and protein expression of TGF beta ( 1 ) , fibronectin and plasminogen activator inhibitor 1 was determined in the supernatant of cultured glomeruli . ^^^ The changes in glomerular matrix score , fibronectin and plasminogen activator inhibitor 1 production closely followed expression of TGF beta ( 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Thus , visceral cells transfer and release fatty acids more extensively , have increased glucocorticoid and reduced thiazolidinedione responses , produce more angiotensinogen , interleukin 6 and plasminogen activator inhibitor 1 , and secrete less leptin and adiponectin than SAT . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
As reviewed below , rosiglitazone has a beneficial impact on a number of factors associated with insulin resistance and CVD , including microalbuminuria , hypertension , dyslipidaemia , visceral fat , elevated plasminogen activator inhibitor 1 levels and increased concentrations of C reactive protein . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
For example , procoagulant and antifibrinolytic single nucleotide polymorphisms in the promoter and coding regions have been reported for alpha thrombin , fibrinogen , factor 5 , protein C , endothelial protein C receptor , and plasminogen activator inhibitor 1 . ^^^ Single nucleotide polymorphisms of protein C , factor 5 ( e . g . , factor 5 Leiden ) , and plasminogen activator inhibitor 1 are associated with an increased risk of deep venous thrombosis , pulmonary emboli , acute myocardial infarction , and stroke . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Furthermore , vascular endothelial growth factor receptor 1 ( flt 1 ) and plasminogen activator inhibitor 1 , two known Egr 1 responsive genes , were also upregulated in the presence of insulin or glucose . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Similarly , in both groups the plasma levels of fibrinogen , thrombin antithrombin 3 complexes , prothrombin fragments F 1 + 2 , plasminogen activator inhibitor 1 , soluble E selectin , soluble P selectin and von Willebrand factor significantly increased after the procedure ( all p < 0 . 05 vs baseline values ) , without any difference between groups ( all p = NS ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fibrinolytic parameters ( in vitro clot lysis , plasminogen , plasmatic plasminogen activator inhibitor 1 activity , D dimer ) along with lipoprotein ( a ) [ Lp ( a ) ] and fibrinogen were measured . von Willebrand factor , platelet activation and some thrombophilic factors ( activated protein C resistance and factor 5 Leiden mutation , protein C , protein S activity ) were also determined . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Compared with wild type cells , transgenic fibroblasts proliferated more rapidly , produced more extracellular matrix , and showed increased expression of key markers of TGFbeta activation , including plasminogen activator inhibitor 1 , connective tissue growth factor , Smad 3 , Smad 4 , and Smad 7 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Adipocyte anatomy ( size ) , physiology ( growth , catecholamine sensitivity , lipolysis , insulin action ) , and biochemistry ( leptin , plasminogen activator inhibitor 1 , cytokines , renin angiotensin system ) are reported to be relatively site specific , highlighting unique roles of regional adipose tissue depots . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The most prevalent related disturbances are increased plasma levels of plasminogen activator inhibitor 1 , fibrinogen , uric acid , homocysteine , and C reactive protein , as well as visceral adiposity , microalbuminuria , disturbed essential fatty acid metabolism , low availability of lipid soluble antioxidant vitamins , and enhanced expression of tumor necrosis factor alpha in adipose tissues . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Haemostatic ( protein C , antithrombin 3 and plasminogen activator inhibitor 1 ) , hemorheologic ( blood fluidity and components ) and inflammatory profiles ( polymorphonuclear elastase and leukocyte count ) were determined using standard methodology . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Venous leg ulcers in a patient with Klinefelter ' s syndrome and increased activity of plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Renal volume , renal blood flow , and glomerular filtration rate were similarly decreased in RAS and HC+RAS ischemic kidneys , accompanied by similar increased expression of profibrotic factors like transforming growth factor beta , tissue inhibitor of metalloproteinase 1 , and plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Using the aorto caval model of an AV fistula model in the rat , we demonstrate marked up regulation in such proinflammatory genes as monocyte chemoattractant protein 1 , plasminogen activator inhibitor 1 , and endothelin 1 , 2 weeks after the creation of the fistula . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
C reactive protein and plasminogen activator inhibitor 1 are circulating markers of low grade inflammation , thrombosis , and vascular injury . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Automated latex photometric immunoassay for total plasminogen activator inhibitor 1 in plasma . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Associated with this gender difference in striatal dopamine depletion were significantly decreased mRNA levels of plasminogen activator inhibitor 1 and a trend for increased ( p = 0 . 06 ) mRNA levels of glial fibrillary acidic protein within females . ^^^ The results suggest that the neuroprotective advantage displayed by females may in part be related to reductions in the transforming growth factor beta injury response as indicated by decreased mRNA plasminogen activator inhibitor 1 and an increased response of reactive astrocytes which promote neuronal survival as indicated by augmented glial fibrillary acidic protein mRNA levels . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
It has been reported that statins inhibit the migration and proliferation of vascular smooth cells ( VSMCs ) , reduce interleukin 6 expression in VSMCs , improve endothelium dependent vasomotion , and inhibit the expression of plasminogen activator inhibitor 1 and matrix metalloproteinases in endothelial cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The clinical course of the patients was prospectively recorded , and several inflammatory and fibrinolytic markers ( C reactive protein , fibrinogen , interleukin 6 , plasminogen activator inhibitor 1 , prothrombin time , activated partial thromboplastin time , platelets , and white blood cell counts ) were determined before surgical intervention ; 24 , 48 , and 72 hours thereafter ; and at hospital discharge . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
RESULTS AND CONCLUSION : Damaged vascular endothelial cells overproduce plasminogen activator inhibitor 1 , which , with excess production of thrombin , leads to fibrnolysis suppressive DIC and fibrin formation in the microvasculature . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Insulin like growth factor 1 and transforming growth factor beta 1 costimulation markedly increased extracellular matrix proteins ( collagen type 1 , fibronectin , and plasminogen activator inhibitor 1 ) compared with cultures with transforming growth factor beta 1 alone . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Other accompanying abnormalities may include elevated levels of leptin , TNFalpha , tissue plasminogen activator , plasminogen activator inhibitor 1 , and testosterone . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The morphological changes after kallikrein gene transfer were associated with decreases in JNK activation as well as transforming growth factor ( TGF ) beta 1 and plasminogen activator inhibitor 1 levels in the heart . ^^^ These results indicate that kallikrein kinin attenuates cardiac hypertrophy and fibrosis and enhances capillary growth in SHR through the suppression of JNK , TGF beta 1 , and plasminogen activator inhibitor 1 via the nitric oxide cGMP pathway . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We measured plasma concentrations of homocysteine , fibrinogen , antithrombin , tissue factor , tissue factor pathway inhibitor , tissue plasminogen activator , plasminogen activator inhibitor 1 , plasminogen , alpha ( 2 ) antiplasmin , lipoprotein ( a ) , protein C , protein S , factor 7 , and activated factor 7 . ^^^ Tissue factor , antithrombin , plasminogen , tissue plasminogen activator , plasminogen activator inhibitor 1 , lipoprotein ( a ) , diabetes , and smoking also had associations . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Seven days animal survival , hepatic tissue blood flow , liver function test , hepatic venous blood concentration of endothelin 1 and plasminogen activator inhibitor 1 , liver tissue biochemistry , and histopathology were analyzed . ^^^ In addition , FR 167653 significantly inhibited release of both endothelin 1 and plasminogen activator inhibitor 1 from the liver cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tryptophan properties in fluorescence and functional stability of plasminogen activator inhibitor 1 . ^^^ Plasminogen activator inhibitor 1 harbors four tryptophan residues at positions 86 , 139 , 175 , and 262 . ^^^ Conformational distribution analysis revealed that the tryptophan mutants have a similar conformational distribution pattern as wild type plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
While no obvious alteration in actin filament structures was found in the labyrinth layer of ROCK 2 ( / ) placenta and stress fibers were formed in cultured ROCK 2 ( / ) trophoblasts , elevated expression of plasminogen activator inhibitor 1 was found in ROCK 2 ( / ) placenta . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The circadian expression changes of plasminogen activator inhibitor 1 , a clock regulated gene , were attenuated in the hearts of DS H . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Long term supplementation with either dietary EPA+DHA or estimated biologically equivalent amounts of ALA did not affect factors VIIa , VIIc , VIIag , XIIa , XIIag , fibrinogen concentrations , plasminogen activator inhibitor 1 or tissue plasminogen activator activity compared with the control . ( n 3 ) PUFA of plant or marine origin do not differ from one another or from LA in their effect on a range of blood coagulation and fibrinolytic factors . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Common variations in the genes encoding factor 5 , prothrombin , angiotensin 1 converting enzyme , 5 , 10 methylenetetrahydrofolate reductase , endothelial cell nitric oxide synthase , tissue plasminogen activator , plasminogen activator inhibitor 1 , and fibrinogen were evaluated . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The link between high levels of plasminogen activator inhibitor 1 and CHD has been confirmed , although the essence of this relationship is not established . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Likewise , atherosclerotic rabbits had reduced plasma tissue type plasminogen activator activity and D dimer levels and an increase in plasminogen activator inhibitor 1 activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Finally , the levels of thrombogenic markers ( tissue plasminogen activator and plasminogen activator inhibitor 1 ) secreted by HUVEC monolayers on aECM 1 were found to be similar to those secreted by HUVEC monolayers cultured on fibronectin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 and the calculus of mortality after myocardial infarction . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
People with the metabolic syndrome had more atherosclerosis ( maximum intimal medial thickness , 0 . 78+ / 0 . 18 versus 0 . 74+ / 0 . 18 mm ; P=0 . 0005 ) , CVD ( 17 . 2 % versus 7 . 0 % ; P=0 . 0001 ) , and elevated plasminogen activator inhibitor 1 ( 24 . 2 versus 14 . 6 U / mL ; P=0 . 001 ) compared with levels among people without the metabolic syndrome . ^^^ This difference in CVD prevalence among the groups was attenuated after adjustment for plasminogen activator inhibitor 1 levels , suggesting that fibrinolytic dysfunction mediates the increased risk of CVD in individuals with the metabolic syndrome . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Because visceral and subcutaneous adipose tissues are the major sources of cytokines ( adipokines ) , increased adipose tissue mass is associated with alteration in adipokine production ( eg , overexpression of tumor necrosis factor a , interleukin 6 , plasminogen activator inhibitor 1 , and underexpression of adiponectin in adipose tissue ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Baseline procoagulability scores and procoagulability scores in response to a 15 min speech task included plasma thrombin / antithrombin 3 complex , D dimer , von Willebrand factor , tissue type plasminogen activator , and plasminogen activator inhibitor 1 levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In all four patients , ( 1 ) the conditioning regimen induced total body irradiation , ( 2 ) serological reactivation of cytomegalovirus and / or human herpesvirus 6 preceded the onset of IIP , ( 3 ) their human leucocyte antigen types were among those suspected to increase susceptibility to angiitis syndrome , ( 4 ) serum anti H . pylori antibody was positive before conditioning and remained positive throughout the post transplantation course , ( 5 ) inflammatory cytokines ( interleukin 6 , 8 and 12 ) were increased during the period of leucocyte recovery after transplantation and ( 6 ) the levels of intercellular adhesion molecule 1 , thrombomodulin and plasminogen activator inhibitor 1 were increased at the onset of IIP . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Additionally , elevated levels of plasminogen activator inhibitor 1 , factor ( F ) 7 , FXII , fibrinogen and tissue plasminogen activator occur with insulin resistance to create an atherothrombotic risk cluster . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Several serpins are involved in hemostasis : antithrombin ( AT ) inhibits many coagulation proteases , most importantly factor Xa and thrombin ; heparin cofactor 2 ( HCII ) inhibits thrombin ; protein C inhibitor ( PCI ) inhibits activated protein C and thrombin bound to thrombomodulin ; plasminogen activator inhibitor 1 inhibits tissue plasminogen activator ; and alpha 2 antiplasmin inhibits plasmin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
RESULTS : Age and gender adjusted HOMA was significantly correlated to plasminogen activator inhibitor 1 ( 0 . 51 , P = 0 . 0001 ) , tissue plasminogen activator antigen ( r = 0 . 40 , P = 0 . 0001 ) , fibrinogen ( r = 0 . 28 , P = 0 . 0001 ) , von Willebrand factor ( r = 0 . 17 , P = 0 . 03 ) , factor XIIa ( r = 0 . 22 , P = 0 . 006 ) factor 7 antigen ( r = 0 . 19 , P = 0 . 02 ) and factor 13 B subunit ( r = 0 . 30 , P = 0 . 001 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
However , nuclear factors NFkB 1 and NFkB 2 , plasminogen activator inhibitor 1 and cofilin 1 are examples of cerebral specific responses . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fibrinogen , plasminogen activator inhibitor 1 and neurocognitive tests were not different between kava use categories . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We previously reported that liganded glucocorticoid receptor ( GR ) repressed TGF beta induction of human plasminogen activator inhibitor 1 gene transcription by directly targeting the transcriptional activation function of Smad 3 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Interestingly , conditional overexpression of PIASy selectively inhibits a subset of endogenous TGF beta responsive genes , which includes the cyclin dependent kinase inhibitor p 15 , and the plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
RESULTS : Ischemia led to strong upregulation of mRNA transcripts for heat shock proteins 70 , 27 , 105 , 86 and 40 kDa , vascular endothelial growth factor , brain derived neurotrophic factor , plasminogen activator inhibitor 1 , activating transcription factor 3 , B cell translocation gene 2 , and growth arrest and DNA damage inducible 45 alpha protein compared to the NI tissue . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Levels in HSC of mRNA for collagen type 1 , collagen type 4 , TGF beta , and plasminogen activator inhibitor 1 were unaffected by exposure to CM but increased significantly when CM from iron loaded hepatocytes was heat treated . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
TSH did not affect plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The balance of adipose derived substances , including free fatty acids , tumor necrosis factor alpha , leptin , adiponectin , and plasminogen activator inhibitor 1 , determine both insulin action and the state of vascular inflammation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In particular , high resting plasminogen activator inhibitor 1 may diminish the magnitude of tissue plasminogen activator response during acute exercise . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Significant positive associations with BMI were seen for factor VIIc , activated factor 12 , antithrombin activity , protein C activity and plasminogen activator inhibitor 1 activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This activity was completely inhibited by plasminogen activator inhibitor 1 and by amiloride , identifying the activity as urokinase plasminogen activator ( uPA ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Age , BMI , antihypertensive treatment , HbA ( 1c ) , fasting blood glucose , blood lipids , insulin , proinsulin , HOMA IR , and plasminogen activator inhibitor 1 did not add predictive power . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 , connective tissue growth factor , and TGF beta 1 were upregulated in MRL / lpr mice compared with MRL / + mice and were normalized by Crry Ig treatment , suggesting that the product of these genes may contribute to the progressive glomerulosclerosis in MRL / lpr mice in a complement dependent fashion . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Until the age of 6 months , plasma concentrations of plasminogen and alpha ( 2 ) antiplasmin are decreased to 50 % and 80 % of adult values , respectively , while plasma concentrations of tissue type plasminogen activator are decreased and plasminogen activator inhibitor 1 are increased throughout childhood . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Results of various studies suggest favorable effects of ACE inhibitors and ARBs on markers of these components , including effects on plasminogen activator inhibitor 1 , endothelin 1 , and nitric oxide by ACE inhibitors , and effects on vascular cell adhesion molecule 1 and C reactive protein by ARBs . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Other probable causes of thrombophilia related to retinal vein occlusion include increased levels of plasminogen activator inhibitor 1 and lipoprotein ( a ) , which impair fibrinolysis . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Pre and post therapy plasma levels of the hypoxia induced proteins plasminogen activator inhibitor 1 and vascular endothelial growth factor were measured . ^^^ One complete responder had normalization of vascular endothelial growth factor and plasminogen activator inhibitor 1 levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Mutation of the highly conserved tryptophan in the serpin breach region alters the inhibitory mechanism of plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 levels fell after vitamin C in the estrogen deficient group ( 17 . 0 + / 1 . 6 vs . 14 . 7 + / 0 . 9 IU / ml , p = 0 . 03 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
These analyses generated an MMS factor that was loaded by BMI , waist to hip ratio , subscapular skinfold , triglycerides , HDL , homeostasis model assessment index , plasminogen activator inhibitor 1 antigen , and serum uric acid . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Efficacy was correlated with serial plasma VEGF and plasminogen activator inhibitor 1 levels and with positron emission tomography scans . ^^^ CONCLUSIONS : Although SU 5146 plus low dose IFN exhibits biological activity in RCC as evidenced by significant declines in serial VEGF and plasminogen activator inhibitor 1 plasma levels , the 1 year EFS of 6 % and adverse toxicity profile diminishes enthusiasm for additional studies with this combination in advanced RCC . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Our data also implicate loop 34 40 of FXa in the interaction with the tissue factor pathway inhibitor , in prevention of plasminogen activator inhibitor 1 binding , and in tempering inhibition by heparin activated antithrombin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Antithrombin , protein C , protein S , lupus anticoagulants , homocysteine , factor 5 Leiden mutation , prothrombin 20210G > A polymorphism , methylenetetrahydrofolate reductase ( MTHFR ) 677C > T polymorphism and the 675 ( 4G / 5G ) polymorphism in plasminogen activator inhibitor 1 gene were analysed . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Activation of endogenous cGKI in primary aortic SMCs resulted in cells with increased levels of proliferation ; increased levels of vascular cell adhesion molecule 1 , peroxisome proliferator activated receptor gamma , and phosphatidylinositol 3 kinase / Akt signaling ; and decreased plasminogen activator inhibitor 1 mRNA , which all are potentially proatherogenic properties . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Specifically , we consider polymorphisms in coagulation factors ( fibrinogen , prothrombin , FV Leiden , FVII , and FXIII ) ; fibrinolytic factors ( tissue type plasminogen activator , plasminogen activator inhibitor 1 , and thrombin activatable fibrinolysis inhibitor ) ; platelet surface receptors ; methylenetetrahydrofolate reductase ; endothelial NO synthase ; and the antioxidant enzymes paraoxonase and plasma glutathione peroxidase . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Moreover , FK reduced infiltration of mononuclear cells , especially macrophages , and proliferation of myofibroblasts in renal intestitium and also inhibited renal interstitial fibrosis through the reduction of the expressions of fibrosis related factors , i . e . plasminogen activator inhibitor 1 and transforming growth factor beta 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fibrinolysis was evaluated by the changes in fibrin degradation products ( D dimer ) , determined by enzyme immunoassay , and in the plasminogen activator inhibitor 1 ( PAl 1 ) , by enzymatic assay . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The following parameters were determined in both groups : plasminogen activator inhibitor 1 antigen , tissue plasminogen activator antigen , fibrinogen , fibrin degradation products , thrombomodulin , protein S antigen , protein C activity , von Willebrand factor Ag , factor 7 and factor 12 activity . ^^^ Hypertensive offsprings had significantly higher plasma levels of plasminogen activator inhibitor 1 antigen , fibrinogen , fibrin degradation products , protein S antigen and factor 12 activity , while no differences were observed to the other haemostatic variables studied . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Previous in vitro studies have indicated that some uremic toxins induce oxidative stress and activate NF kappaB to upregulate plasminogen activator inhibitor 1 in tubular cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fasting lipids , lipoprotein ( a ) , fibrinogen , plasminogen activator inhibitor 1 , homocysteine , folate and vitamin B 12 levels were measured . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fibrinolytic factors including tissue plasminogen activator , plasminogen activator inhibitor 1 , tissue plasminogen activator and plasminogen activator inhibitor 1 ratio , lipoprotein ( a ) , and plasminogen also were investigated . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Functional plasminogen and plasminogen activator inhibitor 1 assays were done and found to be deficient . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Using either an artificial SMAD3 / 4 dependent reporter construct or the natural TGF beta target , plasminogen activator inhibitor 1 , we show that membrane permeable dibutyryl cAMP , and other intracellular cAMP elevating agents such as the phosphodiesterase inhibitor isobutyl methylxanthine , the adenylate cyclase activator forskolin , or exogenous prostaglandin E 2 ( PGE 2 ) , interfere with TGF beta induced SMAD specific gene transactivation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Renal lesions and cortical expression of TGF beta 1 , TGF beta 2 , TGF beta 3 , type 2 TGF beta receptor ( TbetaRII ) , Smads , type 1 collagen , and plasminogen activator inhibitor 1 were examined by immunohistochemistry , Western blot , and / or real time reverse transcription polymerase chain reaction ( RT PCR ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
These chemical messengers include adiponectin , resistin , leptin , plasminogen activator inhibitor 1 , tumor necrosis factor alpha , and interleukin 6 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 , tissue factor , and fibrinogen were all significantly reduced in the lesions of trained mice . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
These phenotypes include diabetic dyslipidaemia , elevation of levels of plasminogen activator inhibitor 1 , microalbuminuria and endothelial dysfunction . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Human adipose tissue incubated in primary culture for 48 h released more prostaglandin E ( 2 ) , IL 8 , and IL 6 than adiponectin , whereas the release of plasminogen activator inhibitor 1 and hepatocyte growth factor was less than that of adiponectin but greater than that of leptin . ^^^ Visceral adipose tissue released greater amounts of vascular endothelial growth factor , IL 6 , and plasminogen activator inhibitor 1 compared with abdominal sc tissue . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Lastly , HMG CoA reductase inhibitors appear to have important effects on the thrombogenesis : reduced expression of tissue factor production and activity ; increased production of tissue factor package inhibitor ; decreased platelet thrombus formation and improved fibrinolysis as a result of lowered plasminogen activator inhibitor 1 levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tenecteplase is a triple combination mutant variant of alteplase with high fibrin specificity and resistance to plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
At Day 56 post treatment , fibrosis related parameters such as interstitial matrix deposition , and the expression of genes of TGF beta 1 , plasminogen activator inhibitor 1 , and type 1 collagen were significantly reduced in the kidney in the CGP group . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The analyzed markers correspond to polymorphic sites in several candidate genes for cardiovascular disease including apolipopoteins and their receptors ( APOA 1 , APOB , APOE , APOC 1 , APOC 2 , LPA , and LDLR ) , genes implied in the hemostasis regulation ( Factor 7 , alpha and beta fibrinogen , alpha and beta platelet integrin , tissue plasminogen activator , and plasminogen activator inhibitor 1 ) , and the angiotensin converting enzyme gene . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Assessment of the risk factor profile revealed an absence of classic risk factors but the presence of the factor 5 Leiden mutation , the methylenetetrahydrofolate reductase AI298C mutation , the HFE C282Y mutation , plasminogen activator inhibitor 1 gene mutation , the 455 G / A fibrinogen gene polymorphism , the epsilon3 / epsilon4 apolipoprotein E 675 4G gene polymorphism , and hyperhomocysteinemia . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Baseline APC levels were positively correlated with sequential organ failure assessment and pediatric risk of mortality scores and with d dimers , tumor necrosis factor alpha , interleukin 1 , interleukin 6 , interleukin 8 , plasminogen activator inhibitor 1 , TAT complexes , and PAP complexes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Platelet count , platelet aggregation , beta thromboglobulin , prothrombin fragment F1 . 2 , thrombin antithrombin complex , plasminogen activator inhibitor 1 , alpha 2 plasmin inhibitor plasmin complex , D dimer , neutrophil elastase , and interleukin 6 were measured before , during , and after bypass . ^^^ RESULTS : There were no significant differences between groups in platelet count , beta thromboglobulin , plasminogen activator inhibitor 1 , interleukin 6 , bleeding times , or blood loss . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Indeed , before VAP was diagnosed clinically , plasminogen activator activity levels in NBL fluid gradually declined , which appeared to be caused by a sharp increase in NBL fluid levels of plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Concentration of TGF beta in the conditioned medium was estimated by a bioassay using mink lung epithelial cells transfected with a plasminogen activator inhibitor 1 promoter luciferase construct . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Factor 5 gene , prothrombin gene and tissue factor gene in clotting system , thrombomodulin gene and antithrombin 3 in anticlotting system , plasminogen activator inhibitor 1 gene in fibrinolytic system , are related with hypercoagulability tightly . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OH scavenger DHR attenuated HIF prolyl hydroxylase activity and interaction with von Hippel Lindau protein , leading to enhanced HIF 1alpha levels , HIF 1alpha transactivation , and activated expression of the HIF 1 target genes plasminogen activator inhibitor 1 and heme oxygenase 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 ( PAI 1 ) : in vitro activities and clinical relevance . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We will discuss the functional implications and association with disease risk of polymorphisms in coagulation factors ( fibrinogen , prothrombin , and factor 5 ) ; fibrinolytic factors ( plasminogen activator inhibitor 1 and lipoprotein ( a ) ) ; platelet surface receptors ; and vascular redox determinants ( methylenetetrahydrofolate reductase , endothelial nitric oxide synthase , and the antioxidant enzymes cellular glutathione peroxidase and paraoxonase ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Postprandial variations in fibrinolytic activity in middle aged men are modulated by plasminogen activator inhibitor 1 4G 675 / 5G genotype but not by the fat content of a meal . ^^^ OBJECTIVE : The goal was to determine whether plasminogen activator inhibitor 1 ( PAI 1 ) and fibrinolytic activities are influenced by 1 ) dietary fat intake from a test meal and 2 ) the PAI 1 4G allele . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Multiple mechanisms are at play including up regulation of tissue factor leading to the initiation of clotting , amplification of the clotting process by augmenting exposure of cellular coagulant phospholipids , inhibition of fibrinolysis by elevating plasminogen activator inhibitor 1 ( PAI 1 ) and decreases in natural anticoagulant pathways , particularly targeted toward down regulation of the protein C anticoagulant pathway through multiple mechanisms . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We previously identified an insulin response element in the promoter of plasminogen activator inhibitor 1 ( PAI 1 ) that was activated by an unidentified member of the forkhead / winged helix ( Fox ) family of transcription factors . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In addition , a second independent association was uncovered between a microsatellite polymorphism in the plasminogen activator inhibitor 1 gene , i . e . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A profibrinolytic ( reduction in plasminogen activator inhibitor 1 ) effect was significant only with the LOCF imputation method in observed case and percent change from baseline analyses . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Enhancement of fibrinolysis in poorly controlled , hospitalized type 2 diabetic patients by short term metabolic control : association with a decrease in plasminogen activator inhibitor 1 . ^^^ Impaired fibrinolysis in type 2 diabetes may be caused by an increased plasma concentration of plasminogen activator inhibitor 1 ( PAI 1 ) , although the effects of short term hypoglycemic therapy on fibrinolytic activity are poorly understood . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Laboratory tests included plasma assays of fibrinogen , tissue plasminogen activator ( TPA ) , D dimer , plasminogen activator inhibitor 1 ( PAI 1 ) , plasminogen and factor 7 : c . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We measured four adipocytokines : adiponectin , interleukin ( IL ) 6 , tumor necrosis factor alpha , and plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
However , no association was found between the investigated SNP and inflammatory mediators such as fibrinogen , interleukin 6 , tumor necrosis factor alpha , tissue factor , C reactive protein , plasminogen activator inhibitor 1 , leukotriene B 4 , or thromboxane B 2 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Hybrid selection on high density cDNA array , real time RT PCR , gelatin zymography and immunohistochemistry were used to characterize the mRNA expression profile , activity , and tissue location of extracellular matrix related genes in radiation enteritis compared with healthy ileum . cDNA array analysis revealed a strong induction of genes coding for collagens 1 , 3 , 4 , 6 , and 8 , SPARC , and tenascin C , extracellular matrix degrading enzymes ( MMP 1 , 2 , 3 , 14 , 18+19 ) , and metalloproteinase inhibitors ( TIMP 1 , 2 , plasminogen activator inhibitor 1 ) in radiation enteritis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Monocyte chemoattractant protein 1 levels decreased by 3+ / 3 % and 12+ / 2 % , respectively ( P=0 . 049 and P=0 . 001 , respectively ) , C reactive protein levels changed by 0 % and 18 % , respectively ( P=0 . 036 and P < 0 . 001 , respectively ) , and plasminogen activator inhibitor 1 antigen levels changed by 7+ / 7 % and 17+ / 5 % , respectively ( P=0 . 828 and P < 0 . 001 , respectively ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fibrinolytic activity in peritoneal fluid was assayed by zymography , and expression of tissue plasminogen activator ( tPA ) and plasminogen activator inhibitor 1 , both regulators of fibrinolytic activity , was assessed in peritoneal tissue and fluid by RT PCR and bioassay , respectively . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The GCF levels of albumin , tissue type plasminogen activator ( t PA ) , urokinase type plasminogen activator ( u PA ) , plasminogen activator inhibitor 1 ( PAI 1 ) and plasminogen activator inhibitor 2 ( PAI 2 ) were analysed by enzyme linked immunosorbent assay . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Effect of Tisseel on expression of tissue plasminogen activator and plasminogen activator inhibitor 1 . ^^^ INTERVENTION ( S ) : Measurement of mRNA expression of tissue plasminogen activator ( t PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
These include plasminogen activator inhibitor 1 ( PAI 1 ) , tumor necrosis factor ( TNF alpha ) , leptin and adiponectin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Estrogen regulation of plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Cerebral ischemia / reperfusion in normal and diabetic rats was accompanied by increased expression of tissue plasminogen activator ( t PA ) , urokinase plasminogen activator ( u PA ) , plasminogen activator inhibitor 1 ( PAI 1 ) and neuroserpin ( NSP ) mRNA after reperfusion . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma plasminogen activator inhibitor 1 activity correlated positively with total fat intake ( r=0 . 59 , P =0 . 04 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : We conducted a case control study on a total of 280 patients with Type 2 diabetes , comparing those without retinopathy or nephropathy ( n = 92 ) and those with microangiopathies ( n = 188 ) , for the association of polymorphisms in four candidate genes , paraoxonase 1 ( PON 1 ) , plasminogen activator inhibitor 1 , fibrinogen , and platelet glycoprotein Ibalpha . ^^^ No associations were found between microangiopathies and the other polymorphisms evaluated ( plasminogen activator inhibitor 1 , fibrinogen , and platelet glycoprotein Ibalpha ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
HGI , P < 0 . 01 ) , free fatty acids ( P < 0 . 01 ) , apolipoprotein B , and plasminogen activator inhibitor 1 activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Upregulation of adhesion molecules , generation of chemokines such as macrophage chemoattractant peptide 1 , and production of plasminogen activator inhibitor 1 participate in the inflammatory response and contribute to a prothrombic state . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 and FFA were significantly elevated and adiponectin was significantly lower in Asian Indians vs . ^^^ Thus , apparently healthy Asian Indians have severe insulin resistance , dyslipidemia , elevated plasminogen activator inhibitor 1 , impaired insulin mediated vasodilation , and trends toward altered body fat distribution . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Macrophage inhibitory factor , plasminogen activator inhibitor 1 , other acute phase proteins , and inflammatory mediators normalize as a result of weight loss in morbidly obese subjects treated with gastric restrictive surgery . ^^^ Preoperative as well as 3 , 6 , 12 , and 24 month postoperative plasma concentrations of inflammatory mediators macrophage inhibitory factor , plasminogen activator inhibitor 1 , lipopolysaccharide binding protein , alpha 1 acid glycoprotein , C reactive protein , soluble TNFalpha receptors 55 and 75 , and leptin were measured . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fibrinolytic pathway activation was assessed with levels of tissue plasminogen activator antigen and tissue plasminogen activator activity , plasminogen activator inhibitor 1 activity , and alpha 2 antiplasmin activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The thrombogenic potency of the ruptured plaque may be reduced also by estrogens via downregulating the synthesis of plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Moreover , HK may have profibrinolytic actions as it can ( 1 ) inhibit plasminogen activator inhibitor 1 function and ( 2 ) potentiate prourokinase activation with subsequent pericellular plasmin formation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Most interestingly , DESC 1 formed stable inhibitory complexes with both plasminogen activator inhibitor 1 and protein C inhibitor that are expressed in the same tissues with DESC 1 , suggesting that type 2 transmembrane serine proteases may be novel targets for serpin inhibition . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
RESULTS : Significant RFs for developing type 2 diabetes included high plasminogen activator inhibitor 1 , hypertension , high triglycerides , low levels of HDL cholesterol , and IGT . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
An increase in fibrinogen / fibrin degradation products and a rise in plasminogen activator inhibitor 1 occurred between 4 and 6 h . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The main cause of hypercoagulation state during sepsis seems to be inhibition of fibrinolysis as a result of overproduction of plasminogen activator inhibitor 1 in later stages of the disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
On each patient , we screened the PlA1 / PlA2 polymorphism of the platelet glycoprotein IIIa gene , 4G / 5G polymorphism of the plasminogen activator inhibitor 1 gene , G10976A polymorphism of the factor 7 gene , C677T polymorphism of the methylenetetrahydrofolate reductase gene , and 27 base pair repeat polymorphism of the endothelial nitric oxide synthase gene . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 was 6 U ( normal value 5 20 U / mL ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Statistically significant reductions were observed in fasting glucose , and plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
STUDY DESIGN : Eighty nine allogeneic stem cell recipients and their donors were evaluated prospectively for the presence of the factor 5 G1691A mutation , the prothrombin G20210A mutation , the 5 , 10 methylenetetrahydrofolate reductase ( MTHFR ) C677T mutation , the glycoprotein IIIa PI ( a1 / a2 ) polymorphism , the fibrinogen beta chain 455G / A polymorphism , the plasminogen activator inhibitor 1 675 4G / 5G polymorphism , and the angiotensin converting enzyme intron 16 I / D polymorphism . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In addition , there is a growing list of adipokines involved in inflammation ( TNFalpha , IL 1beta , IL 6 , IL 8 , IL 10 , transforming growth factor beta , nerve growth factor ) and the acute phase response ( plasminogen activator inhibitor 1 , haptoglobin , serum amyloid A ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Monocyte chemoattractant protein 1 expression in lung homogenates was decreased , but the expressions of TNF alpha , IL 6 , matrix metalloproteinase 12 , tissue factor , and plasminogen activator inhibitor 1 were similar in both groups . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
D dimer , plasminogen activator inhibitor 1 , von Willebrand factor , soluble intercellular adhesion molecule 1 , and interleukin 6 were measured in plasma . ^^^ RESULTS : Multivariate analyses showed that D dimer ( median / interquartile range , 242 / 162 419 ng / ml versus 175 / 132 254 ng / ml ; P=0 . 041 ) , plasminogen activator inhibitor 1 ( 36 / 19 61 ng / ml versus 17 / 6 44 ng / ml ; P=0 . 010 ) , von Willebrand factor ( 122 / 91 179 % versus 92 / 66 110 % ; P=0 . 001 ) , and soluble intercellular adhesion molecule 1 ( 227 / 187 291 ng / ml versus 206 / 185 247 ng / ml ; P=0 . 044 ) were all higher in non dippers than in dippers . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Their anthropometric measures , lipids , apoB , C reactive protein , fibrinogen , plasminogen activator inhibitor 1 , fasting and post glucose load glucose , and insulin concentrations were measured , and insulin sensitivity was determined by intravenous glucose tolerance test . ^^^ Moreover , the Spearman correlation of apoB was significantly stronger ( P < 0 . 05 ) in the direction of greater associated risk than that of NHDLC with body mass index , waist circumference , systolic blood pressure , 2 hour glucose , fasting glucose , fasting insulin , 2 hour insulin , insulin sensitivity , C reactive protein , fibrinogen , and plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma levels of procoagulant factors 7 and 10 , anticoagulant proteins C and S , and plasminogen activator inhibitor 1 correlated positively with total and percent central body fat ( r = 0 . 25 0 . 38 ; P < 0 . 05 ) and negatively with insulin sensitivity ( except protein S ; r = 0 . 24 to 0 . 35 ; P < 0 . 05 ) . ^^^ On factor analysis , procoagulant factors 7 and 10 , proteins C and S , and plasminogen activator inhibitor 1 were components of the cluster of variables that explained the greatest proportion of the variance in the data ( 39 . 2 % ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The proband was heterozygous for the G1691A factor 5 Leiden , G20210A prothrombin , and platelet glycoprotein IIIa PL A1 / A2 mutations , had high factor 8 ( 221 % ) , and was homozygous for the 4G4G plasminogen activator inhibitor 1 gene mutation , with high plasminogen activator inhibitor activity ( 23 . 7 U / mL ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Circulating levels of E selectin , P selectin , plasminogen activator inhibitor 1 , and von Willebrand factor , which were higher than those in the control group , decreased significantly after surgery . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
No differences between groups were found in CD 61 , CD62P , and CD42b surface expression , but markers of the coagulation cascade and fibrinolysis or endothelial injury ( F1+2 prothrombin fragments , tissue plasminogen activator inhibitor 1 ) were elevated in patients treated with CyA compared with children on steroids and healthy controls . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
It was also reported that a faster activation of this factor related to the Val 34 leu polymorphism provides protective effect against myocardial infarction and stroke , this effect being however negated in patients with insulin resistance and high plasma levels of plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 plasma level increases with age in subjects with the 4G allele at position 675 in the promoter region . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
After adjusting for age , sex , and current smoking status , there were no significant differences between patients with or without CAD in lipoprotein ( a ) , homocysteine , fibrinogen , plasminogen activator inhibitor 1 , white blood cell count , body mass index , glucose , triglyceride or total cholesterol . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
They had increased senescence associated beta Gal activity , lipofuscin pigment , and plasminogen activator inhibitor 1 expression . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A decrease in plasma fibrinogen and increases in thrombin antithrombin dimers and in serum concentration of plasminogen activator inhibitor 1 occurred before the onset of liver injury . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Involvement of endothelial damage could not be proven , because all investigated patients showed normal tissue plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This reduction in CTGF mRNA level paralleled a reduction in mRNA levels of matrix molecules as well as proteinase inhibitors plasminogen activator inhibitor 1 and tissue inhibitor of metalloproteinase 1 , suppressing renal interstitial fibrogenesis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Human CRP transgenic animal models show that CRP promotes atherothrombosis and increases plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Assays were done for factor 5 Leiden , prothrombin G20210A , methylenetetrahydrofolate reductase C677T , and plasminogen activator inhibitor 1 4G / 5G gene mutations . ^^^ Levels of anticardiolipin antibodies immunoglobulin G and M ( IgG and IgM ) , homocysteine , protein C , protein S , antithrombin 3 , and plasminogen activator inhibitor 1 were also measured . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Microarray analysis showed that a total of 11 genes increased ( IL 8 , core promoter element binding protein , activin A , monocyte chemoattractant protein 1 , Exostoses 1 , Cbp / p300 interacting transactivator with Glu / Asp rich COOH terminal domain 2 , plasminogen activator inhibitor 1 , fibronectin 1 , gravin , connexin 43 , and sortilin related receptor 1 ) and 6 genes decreased ( methionine adenosyltransferase 2A , tryptophan rich basic protein , reticulocalbin 1 , membrane associated RING CH protein 6 , cytoplasmic dynein 1 , and annexin A ( 1 ) ) by more than twofold for their mRNA levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma levels of thrombin antithrombin 3 , fibrin D dimer , von Willebrand factor , tissue type plasminogen activator , and plasminogen activator inhibitor 1 were measured . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Altered lipoprotein metabolism and elevated fibrinogen and plasminogen activator inhibitor 1 activity are associated with GHD , and the risk of hypertension is increased in GH deficient men . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Treatment with SB 431542 prevented TGFbeta induced stimulation of collagen , fibronectin , plasminogen activator inhibitor 1 , and connective tissue growth factor gene expression , TGFbeta autoinduction , and myofibroblast transdifferentiation , and it could reverse stimulation even when added to the cultures after TGFbeta . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In cultured adipocytes , elevated levels of fatty acids increased oxidative stress via NADPH oxidase activation , and oxidative stress caused dysregulated production of adipocytokines ( fat derived hormones ) , including adiponectin , plasminogen activator inhibitor 1 , IL 6 , and monocyte chemotactic protein 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : Diurnal variations in levels of factor 7 ( FVII ) , FVIII , proteins C and S , antithrombin , plasminogen activator inhibitor 1 , prothrombin fragment F1+2 , and D dimers in healthy humans point to the existence of circadian rhythms of coagulation factors . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Genes specifically up regulated by transdifferentiation but not by cellular senescence of PrSCs were metalloproteinase 1 tissue inhibitor ( Timp 1 ) , transgelin ( Tagln ) , gamma 2 actin ( Actg 2 ) , plasminogen activator inhibitor 1 ( Serpinel ) , insulin like growth factor binding protein 3 ( Igfbp 3 ) , parathyroid hormone like hormone ( Pthlp ) , Tgfb 1 , four and a half LIM domains 2 ( Fhl 2 ) , hydrogen peroxide inducible clone 5 ( Hic 5 ) and cartilage oligomeric matrix protein ( Comp ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
No significant changes were found in plasma fibrinogen , plasminogen activator inhibitor 1 activity , tissue plasminogen activator antigen , D dimer , serum lipids or lipoprotein ( a ) concentrations . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In contrast , fibrin / fibrinogen degradation products , D dimer , thrombin antithrombin complex , plasmin alpha 2 antiplasmin complex , soluble fibrin , and total plasminogen activator inhibitor 1 were significantly higher , and the antithrombin activity and protein C levels were lower in the patients with organ dysfunction . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This was mediated by activation of a TGF beta signal as confirmed by the abundant expression of TGF beta protein , the cytoplasmic to nuclear translocation of Smad 4 protein by the administration of gefitinib , and the quantitative assay of the plasminogen activator inhibitor 1 promoter / luciferase construction . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Quantitative real time polymerase chain reaction confirmed the dominance of fluid agitation in gene regulation with the exception of heat shock protein 10 at 24 h and plasminogen activator inhibitor 1 at 6 h . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The conversion of active to latent plasminogen activator inhibitor 1 is an energetically silent event . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
There was no effect of soy on soluble fibrin ( a marker of fibrin production ) , plasminogen activator inhibitor 1 ( a marker of fibrinolytic inhibitory potential ) , D dimer ( a marker of fibrin turnover ) , or von Willebrand factor ( a marker of endothelial damage ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Cultured pressure ulcer fibroblasts show replicative senescence with elevated production of plasmin , plasminogen activator inhibitor 1 , and transforming growth factor beta 1 . ^^^ Senescent pressure ulcer fibroblasts generated significantly more plasminogen activator inhibitor 1 ( 1179 . 27 + / 25 . 37 ng / mg protein ) than normal skin fibroblasts of the same age ( 132 . 16 + / 16 . 20 ng / mg protein ; p = 0 . 0357 ) . ^^^ Although senescent ulcer fibroblasts produce elevated levels of plasminogen activator inhibitor 1 and transforming growth factor beta 1 , the ratio of these factors to plasmin levels suggests that this may have little influence on extracellular matrix synthesis or maintenance in the chronic wound . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Extent of intra abdominal fat had significant linear relations with six metabolic coronary risk factors : systolic and diastolic blood pressure , fasting blood concentrations of glucose , high density lipoprotein ( HDL ) cholesterol , triglyceride , and plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Selective promotion of plasminogen activator inhibitor 1 secretion by activation of proteinase activated receptor 1 in cultured human brain microvascular pericytes : comparison with endothelial cells . ^^^ Specifically , thrombin increases the secretion of fibrinolytic proteins ( tissue and urokinase type plasminogen activators and plasminogen activator inhibitor 1 ) , resulting in an enhancement of plasminogen activator activity in endothelial cells , whereas the proteinase increases the secretion of only plasminogen activator inhibitor 1 by activation of proteinase activated receptor 1 and induces suppression of plasminogen activator activity in pericytes . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
EGFR phosphorylation and beta catenin activation were inhibited by plasminogen activator inhibitor 1 and pertussis toxin , two inhibitors of the urokinase type plasminogen activator ( uPA ) / uPA receptor system . beta Catenin activation was correlated with the phosphorylation of glycogen synthase kinase 3beta through a phosphatidylinositol 3 kinase / Akt dependent mechanism . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Genes that were > or =6 fold different between long and short day testes ( i . e . hypoxia inducible factor 1alpha ( Hif1alpha ) , plasminogen activator inhibitor 1 ( Serpine 1 ) , transforming growth factor beta receptor 3 ( Tgfbetar 3 ) and tumour necrosis factor ( Tnf ) ) were sequenced and expression differences were compared throughout gonadal regression and recrudescence using quantitative RT PCR . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Pivotal role of plasminogen activator inhibitor 1 in vascular disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
No significant differences were found in fasting lipid profile , apolipoproteins , fibrinogen , plasminogen activator inhibitor 1 , E selectin , or homocysteine between the two study periods . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Furthermore , our results suggest that hK 5 can potentially release ( a ) angiostatin 4 . 5 from plasminogen , ( b ) `` cystatin like domain 3 ' ' from low molecular weight kininogen , and ( c ) fibrinopeptide B and peptide beta 15 42 from the Bbeta chain of fibrinogen . hK 5 could also play a role in the regulation of the binding of plasminogen activator inhibitor 1 to vitronectin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
LysoPC also induced the mRNA expression of urokinase type plasminogen activator ( uPA ) , uPA receptor , and plasminogen activator inhibitor 1 , but the kinetics were different from that of tPA . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Hemostatic factors , i . e . , fibrogen , antithrombin , protein C activity , plasminogen activator inhibitor 1 , D dimer , and plasminogen , were measured in plasma of all women before , and 6 and 12 months after the start of study . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
RT PCR analysis of cardiac mRNA revealed differential expression of angiogenic or tissue remodeling genes , such as vascular endothelial cell growth factor ( VEGF ) , VEGF receptors , plasminogen activator inhibitor 1 , endothelin 1 , and matrix metalloproteinase 9 , which varied with time or amount of exposure . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Tibolone lowers lipoprotein ( a ) , fibrinogen , and plasminogen activator inhibitor 1 levels and improves glucose tolerance , insulin sensitivity , and endothelial function ; however , it also lowers high density lipoprotein cholesterol by > 20 % . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Adipose tissue plays an important role in insulin resistance through the dysregulated production and secretion of adipose derived proteins , including tumor necrosis factor alpha , plasminogen activator inhibitor 1 , leptin , resistin , angiotensinogen , and adiponectin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Several biologic markers of mortality have also been identified in large studies , including von Willebrand factor antigen , surfactant protein D , protein C , plasminogen activator inhibitor 1 , interleukins 6 and 8 , and the TNF receptors . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We examined the mRNA levels of urokinase plasminogen activator , plasminogen activator inhibitor 1 and the matrix metalloproteases MMP 2 , 3 , 11 , 13 and 14 , and found that all these seven genes are predominantly expressed by stromal cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The following metabolic and genetic risk factors were evaluated : lipoprotein ( a ) , homocysteine , antiphospholipid antibodies , plasminogen activator inhibitor 1 , factor 5 Leiden mutation , prothrombin variant , and 5 , 10 methylenetetrahydrofolate reductase ( MTHFR ) C677T polymorphism . ^^^ RESULTS : Multivariate logistic regression analysis , adjusted for traditional cardiovascular risk factors , showed a significant association between PAD symptoms and prothrombin variant , altered levels of homocysteine , lipoprotein ( a ) , plasminogen activator inhibitor 1 , and antiphospholipid antibodies . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Variables measured included proteinuria , blood pressure , tubulointerstitial and glomerular matrix accumulation , expression of transforming growth factor beta ( 1 ) , fibronectin , and plasminogen activator inhibitor 1 , infiltration of lymphocytes and macrophages , plasma creatinine and urea levels , and glomerular filtration rate . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Regression of glomerulosclerosis with high dose angiotensin inhibition is linked to decreased plasminogen activator inhibitor 1 . ^^^ Regression was not explained by changes in mRNA of TGF beta 1 and matrix metalloproteinase 2 and 9 but was linked to decreased tissue inhibitor of metalloproteinase 1 and plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This syndrome also has features of a hypercoagulable state , consisting of increased levels of clotting factors ( tissue factor , factor 7 and fibrinogen ) as well as inhibition of the fibrinolytic pathway ( increased plasminogen activator inhibitor 1 and decreased tissue plasminogen activator activity ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Moreover , treatment of HSCs with both TGF beta and PDGF increased transcriptional activity of plasminogen activator inhibitor 1 through linker phosphorylation of Smad 3 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Western blot analysis confirmed a significant increase in AIIt in MS lesions and in a proportion of normal appearing white matter samples , with a highly significant correlation between annexin 2 levels and factors associated with impeded fibrinolysis , such as plasminogen activator inhibitor 1 . ^^^ Our results suggest that limited availability of tPA in MS lesions because of formation of tPA plasminogen activator inhibitor 1 complexes reduces capability of tPA receptors to generate plasmin , which further diminishes fibrinolytic capacity in active MS lesions and possibly leads to axonal damage . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
No significant differences between cases and controls were found in plasminogen activator inhibitor 1 or tissue plasminogen activator cord blood levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Myocardial interstitial fibrosis , transcriptional activities of activator protein 1 and nuclear factor kappaB , and mRNA expression of monocyte chemoattractant protein 1 , plasminogen activator inhibitor 1 , atrial natriuretic peptide , brain natriuretic peptide , and collagen types 1 and 3 were significantly increased at four weeks after MI . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Fibrinolytic activation and an increased secondary inhibition of fibrinolysis were detected by increased levels of D dimer and plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We measured levels of von Willebrand factor antigen , thrombomodulin , tissue type plasminogen activator , plasminogen activator inhibitor 1 and d dimer in the plasma using enzyme linked immunosorbent assay . ^^^ RESULTS : We found increased levels of von Willebrand factor antigen ( p = 0 . 01 ) , tissue type plasminogen activator ( p = 0 . 01 ) , and decreased levels of thrombomodulin ( p = 0 . 008 ) in the patients when compared to controls , while levels of plasminogen activator inhibitor 1 were not different . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Association of interleukin 6 gene G 174C polymorphism and plasma plasminogen activator inhibitor 1 level in Chinese patients with and without hypertension . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Effects of hypoxia and tumor necrosis factor alpha on production of plasminogen activator inhibitor 1 in human proximal renal tubular cells ] . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
MAIN OUTCOME MEASURES : The main outcome measures were : 1 ) inflammatory markers associated with CVD including C reactive protein , IL 6 , and plasminogen activator inhibitor 1 ; 2 ) the adipokine adiponectin ; and 3 ) conduit vessel stiffness . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Similar expression patterns were observed for urokinase plasminogen activator ( uPA ) , uPA receptor , and plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Baicalein inhibits thrombin induced production of plasminogen activator inhibitor 1 , and interleukin 1beta and tumor necrosis factor alpha induced adhesion molecule expression in cultured human umbilical vein endothelial cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Interestingly , activated matriptase 3 formed stable inhibitor complexes with an array of serpins , including plasminogen activator inhibitor 1 , protein C inhibitor , alpha 1 proteinase inhibitor , alpha 2 antiplasmin and antithrombin 3 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
RESULTS : Polymorphisms in genes coding for proteins involved in the recognition of bacterial pathogens ( Toll like receptor 4 , CD 14 , Fc ( gamma ) RIIa , and mannose binding lectin ) and the response to bacterial pathogens ( tumor necrosis factor alpha , interleukin ( IL ) 1alpha , IL 1beta , IL 1 receptor agonist , IL 6 , IL 10 , heat shock proteins , angiotensin 1 converting enzyme , plasminogen activator inhibitor 1 ) can influence the amount or function of the protein produced in response to bacterial stimuli . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Increased plasminogen activator inhibitor 1 levels in android obesity : correlation with oxidative stress . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In addition , a significant reduction of postprandial plasminogen activator inhibitor 1 was observed in comparison with the baseline values after nateglinide ( P=0 . 001 ) , although the overall response was not significantly different after nateglinide and placebo ( P=0 . 31 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Serum levels of lipids [ high density lipoprotein and low density lipoprotein cholesterol , triglycerides and lipoprotein ( a ) ] and hemostatic factors ( prothrombin , fibrinogen , plasminogen activator inhibitor 1 , and fibrin D dimer ) were also measured . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Mean plasminogen activator inhibitor 1 concentrations decreased ( 39 . 0 % ) in the experimental diet group but increased ( 33 . 1 % ) in the conventional diet group ( P = 0 . 004 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A critical review of classical and newer individual molecular markers , such as hormone receptors , HER 2 , urokinase type plasminogen activator and plasminogen activator inhibitor 1 , cyclin E , topoisomerase 2 , and p 53 , was performed , and the preliminary results obtained using the new gene expression profiling technology are described along with their potential clinical implications . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
MAIN OUTCOME MEASURES : Fasting blood ( 50 ml ) was obtained , and the following parameters were assayed : high sensitivity CRP , fibrinogen , lipid profile , insulin , whole blood cytokines after stimulation with lipopolysaccharide ( LPS ; 100 ng / ml for 24 h ) , soluble cell adhesion molecules , plasminogen activator inhibitor 1 , CD 40 , CD 40 ligand , leptin , adiponectin , monocyte chemoattractant protein 1 , IL 8 , matrix metalloproteinase 3 ( MMP 3 ) , and MMP 9 . ^^^ The markers of inflammation , plasminogen activator inhibitor 1 , MMP 9 , fibrinogen , and vascular cell adhesion molecule 1 levels were significantly higher in the high compared with the low CRP group . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The invasion capabilities of JAr cells and HTR 8 / SV neo cells were also enhanced by ADM , and this was associated with increased gelatinolytic activity and reduced plasminogen activator inhibitor 1 mRNA expression ( SERPINE 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Taken together , our data suggest that astrocytic alpha ( 5 ) beta 8 acts as a central regulator of brain vessel homeostasis through regulation of TGF beta activation and expression of TGF beta responsive genes that promote vessel differentiation and stabilization , most notably plasminogen activator inhibitor 1 and thrombospondin 1 . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
INTRODUCTION : Insulin resistance , a novel cardiovascular risk factor , is often associated with increased plasminogen activator inhibitor 1 levels and impaired vasodilation . ^^^ Insulin infusion in the forearm induces plasminogen activator inhibitor 1 and tissue plasminogen activator expression and endothelium dependent vasodilation in normal subjects . ^^^ In 16 women with polycystic ovary syndrome , 8 insulin resistant and 8 insulin sensitive , blood flow , plasminogen activator inhibitor 1 and tissue plasminogen activator expression were evaluated during insulin infusion into the forearm . ^^^ RESULTS : Elevated basal plasminogen activator inhibitor 1 levels were found in women with polycystic ovary syndrome , correlating directly with insulin levels . ^^^ Plasminogen activator inhibitor 1 expression increased during insulin infusion in all women with polycystic ovary syndrome , but was delayed and sustained in insulin resistant patients ( p < 0 . 01 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The plasminogen / plasmin system includes the uPA , its receptor , and its inhibitor ( plasminogen activator inhibitor 1 ) . ^^^ In previous studies , we found that uPA regulates cell surface fibrinolysis by regulating its own expression as well as that of the uPA receptor and plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A significant decrease was also observed in the renal expression of growth factors ( connective tissue growth factor and vascular endothelial growth factor ) and matrix metalloproteinase inhibitor ( plasminogen activator inhibitor 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : Levels of plasma tissue factor , plasminogen activator inhibitor 1 , tissue factor pathway inhibitor , fibrin split products , D dimers and free thrombomodulin were measured following the administration of rhFVIIa in 17 subjects . ^^^ No changes in plasminogen activator inhibitor 1 , fibrin split products or D dimer levels occurred . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Secreted factors of particular interest include many cytokines or chemokines , such as TNF alpha , IL 6 , IL 8 , as well as plasminogen activator inhibitor 1 , angiotensin 2 , leptin , and adiponectin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Among adipocytokines , tumor necrotizing factor alpha , plasminogen activator inhibitor 1 , and heparin binding epidermal growth factor like growth factor are produced in adipocytes as well as already known organs , and they contribute to the development of vascular diseases . ^^^ Visceral fat accumulation causes dysfunction of adipocytes including oversecretion of tumor necrotizing factor alpha , plasminogen activator inhibitor 1 , and heparin binding epidermal growth factor like growth factor , as well as hyposecretion of adiponectin , which results in the development of a variety of metabolic and circulatory diseases . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The mRNA expression of chemokines ( MCP 1 / CCL2 , MIP 1alpha / CCL3 , IP 10 / CXCL10 , RANTES / CCL5 ) and proteins associated with fibrosis ( plasminogen activator inhibitor 1 , transforming growth factor beta 1 , and collagens 1 and 3 ) were strikingly lower in treated allografts . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Vitamin D analogs down regulate plasminogen activator inhibitor 1 in human coronary artery smooth muscle cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We also found that high glucose significantly stimulated TFB cells to produce profibrotic molecules , such as type 1 collagen , the EIIIA isoform of fibronectin , and plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : To compare concentrations of factor 7 coagulant activity ( factor VIIc ) , fibrinogen , plasminogen activator inhibitor 1 , and blood lipids on a saturated fat rich diet with one rich in monounsaturated fat . ^^^ MAIN OUTCOME MEASURES : Differences in fasting factor VIIc , fibrinogen , plasminogen activator inhibitor 1 , insulin , low density lipoprotein cholesterol , high density lipoprotein cholesterol , triglycerides , apolipoproteins A 1 and B , and plasma oleic acid levels while receiving the SFA diet vs MUFA diet . ^^^ RESULTS : Factor VIIc was lower on the MUFA diet ( P < . 05 ) but fibrinogen and insulin concentrations and plasminogen activator inhibitor 1 activity did not differ between diets . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
There is also interest in Factor IXa inhibitors , thrombin receptor antagonists and inhibitors of plasminogen activator inhibitor 1 . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
RESULTS : At admission , 67 patients had a systemic inflammatory response with increased interleukin 6 and coagulation activity ( thrombin antithrombin complex ) , reduced anticoagulation ( antithrombin , protein C , and protein S ) , activated fibrinolysis ( plasmin antiplasmin complex ) , and , in some cases , inhibited fibrinolysis ( increased plasminogen activator inhibitor 1 with a peak on day 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Messenger RNA levels of tissue type plasminogen activator , urokinase type plasminogen activator , and plasminogen activator inhibitor 1 were analysed using Taqman real time reverse transcriptase polymerase chain reaction and protein release by enzyme linked immunosorbent assay . ^^^ By contrast , plasminogen activator inhibitor 1 mRNA expression and protein secretion increased at all timepoints ( 16 47 % ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Commonly diagnosed thrombophilic states in our population currently include protein S or C deficiency , antiphospholipid antibodies , and less commonly ATIII deficiency , factor 5 Leiden mutation , G20210A PT mutation , and plasminogen activator inhibitor 1 mutation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Elevated tissue plasminogen activator antigen and plasminogen activator inhibitor 1 levels except at menstruation and total protein S except at follicular phase were observed in overweight women together with increased plasminogen level only at luteal phase . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A number of adipokines , including adiponectin , tumour necrosis factor alpha , interleukin ( IL ) 1beta , IL 6 , IL 8 , IL 10 , monocyte chemoattractant protein 1 , macrophage migration inhibitory factor , nerve growth factor , vascular endothelial growth factor , plasminogen activator inhibitor 1 and haptoglobin , are linked to inflammation and the inflammatory response . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The level of vascular endothelial growth factor ( VEGF ) and four other endothelial hemostatic factors ( tissue plasminogen activator , plasminogen activator inhibitor 1 , von Willebrand factor , and D dimers ) were measured in patients before and after 35 hours of EECP treatment . ^^^ CONCLUSIONS : Vascular endothelial cells play a critical role in the regulation of coagulation because they control the expression of tissue plasminogen activator , plasminogen activator inhibitor 1 , von Willebrand factor , and D dimers . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In patients with VTE , plasma levels of D dimer , soluble fibrin , GE XDP and plasminogen activator inhibitor 1 did not correlate with TF mRNA or TF antigen . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
There was an inverse relationship between retinopathy severity and total cholesterol , triglycerides , and plasminogen activator inhibitor 1 as well as with smoking history . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the present study , we found that db / db mice on the FVB genetic background with loss of function mutation of the leptin receptor ( FVB Lepr ( db ) mice or FVBdb / db ) develop severe diabetic nephropathy , including glomerulosclerosis , tubulointerstitial fibrosis , increased expression of type 4 collagen and fibronectin , and proteinuria , which is associated with increased renal mRNA abundance of transforming growth factor beta , plasminogen activator inhibitor 1 , and vascular endothelial growth factor . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Using mice deficient in tissue type plasminogen activator ( tPA / ) and urokinase plasminogen activator receptor ( uPAR / ) , we investigated the involvement of the PA system on the clinical and pathological features of experimental allergic encephalomyelitis , an animal model of multiple sclerosis . tPA / mice suffered an early and a more severe acute disease characterized by incomplete recovery when compared to wild type controls , with significantly higher CNS levels of plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The inherited thrombophilia , gene polymorphisms of coagulation and anticoagulation factor such as thrombomodulin , endothelial protein C receptor , plasminogen activator inhibitor 1 , and factor 13 ; human lymphocyte antigen ( HLA G ) ; detoxification enzymes ( glutathione S transferase M 1 ) ; cytokines such as interleukin ( IL ) 1 and IL 6 ; hormones ( CYP 17 ) ; vasodilators ( nitric oxide synthase 3 ) ; and vitamins ( transcobalamin ) are involved in the pathogenesis of sporadic and recurrent miscarriage . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Blood samples were analyzed for protein C ( PC ) ; protein S ; antithrombin ( AT ) ; activated PC resistance ( APCR ) ; lipoprotein ( a ) [ Lp ( a ) ] ; lupus anticoagulant ; anticardiolipin antibodies ; and the methylenetetrahydrofolate reductase C677T ( MTHFR ) , factor 5 G1619A , factor 2 G20210A ( PT ) , plasminogen activator inhibitor 1 4G6755G , and tissue factor pathway inhibitor C536T mutations . ^^^ RESULTS : At least 1 prothrombotic abnormality was identified in 63 % ( 36 of 57 ) of children studied , including plasminogen activator inhibitor 1 4G6755G ( 15 of 56 ) , MTHFR ( 12 of 56 ) , elevated Lp ( a ) ( 12 of 59 ) , APCR ( 11 of 58 ) , factor 5 G1619A ( 5 of 57 ) , PT ( 3 of 57 ) , PC deficiency ( 1 of 59 ) , and AT deficiency ( 1 of 59 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
No changes in TNFalpha , IL 6 , IL 10 , plasminogen activator inhibitor 1 , haptoglobin , intercellular adhesion molecule , or vascular cell adhesion molecule were seen between the groups . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The nut intervention had no significant effect on von Willebrand factor antigen , fibrinogen , factor 7 coagulant activity , plasminogen activator inhibitor 1 activity , tissue plasminogen activator activity or thrombin activatable fibrinolysis inhibitor . ^^^ Tissue plasminogen activator activity , plasminogen activator inhibitor 1 activity and von Willebrand factor antigen clustered into a separate endothelial function factor . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
It also secretes adipocytokines , which can modify vascular responses , and antifibrinolytics , including plasminogen activator inhibitor 1 , which favors fibrin accumulation , and proinflammatory cytokines , which facilitate the inflammatory response . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In prospective population studies , cardiovascular risk assessment in individuals with the metabolic syndrome is improved by measures of low density lipoprotein ( LDL ) particle number , C reactive protein , and plasminogen activator inhibitor 1 levels . ^^^ Risk assessment models for patients with the metabolic syndrome should consider inclusion of LDL particle number , inflammatory markers , and levels of plasminogen activator inhibitor 1 . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The adipose tissue has been recognized as an important source of metabolically active secretory products ( adipocytokines ) , free fatty acids , leptin , TNF alpha , Iinterleucin 6 , plasminogen activator inhibitor 1 , adiponectin and resistin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Exposure to nicotine may also increase plasminogen activator inhibitor 1 ( a major regulator of fibrinolysis ) , although the extent to which nicotine enhances coagulation is unresolved . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The haemostatic ( protein C activity PtC , antithrombin 3 , plasminogen activator inhibitor 1 ) , haemorheologic ( blood fluidity and components , erythrocyte membrane fluidity ) and inflammatory ( polymorphonuclear elastase , leukocyte count ) profiles were determined at hospital discharge , using standard methodology . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
OBJECTIVE : C reactive protein ( CRP ) can promote atherothrombosis by decreasing endothelial nitric oxide synthase and prostacyclin , and by stimulating both plasminogen activator inhibitor 1 in endothelial cells and tissue factor in mononuclear cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Recently , we reported that AF was associated with endocardial dysfunction , limited to the left atrium ( LA ) and LAA and manifest as reduced nitric oxide ( NO * ) production and increased expression of plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Interestingly , we observed that fibrin also induced the expression of tissue type plasminogen activator ( tPA ) , urokinase type plasminogen activator ( uPA ) and plasminogen activator inhibitor 1 by casein zymographic and reverse zymographic analysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Using RT PCR , mRNAs encoding the following adipokines were detected in dog white adipose tissue : adiponectin , leptin , angiotensinogen , plasminogen activator inhibitor 1 , IL 6 , haptoglobin , metallothionein 1 and 2 , and nerve growth factor . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Decrease in plasma TBARS levels correlated with the decrease in Plasminogen Activator Inhibitor 1 ( r = 0 . 72 ; P < 0 . 003 ) and free fatty acids concentrations ( r = 0 . 62 ; P < 0 . 01 ) . ^^^ At time 120 ' of meal test , repaglinide vs glimepiride administration was associated with a significant decline in plasma triglycerides , free fatty acids , fibrinogen , Plasminogen Activator Inhibitor 1 , plasmin alpha ( 2 ) antiplasmin complex , thrombin antithrombin complex , TBARS levels and increase in plasma HDL cholesterol levels . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The localization of active transforming growth factor beta ( TGFbeta ) was determined by coculture assay using TMLC cells ( mink lung epithelial reporter cells that stably express a portion of the plasminogen activator inhibitor 1 promoter ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Thymosin beta 4 , a protein with relevant interactions with plasminogen activator inhibitor 1 , angiogenesis , and wound healing , was identified as a key differentially expressed protein . ^^^ Downregulation of thymosin beta 4 by RNAi in cultured glomerular endothelial cells decreased angiotensin 2 induced plasminogen activator inhibitor 1 expression . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Muscle viability , local neutrophil chemoattractant protein , interleukin 6 , interleukin 1beta , D dimer , thrombin antithrombin 3 complex , plasminogen activator inhibitor 1 , and tissue plasminogen activator levels were measured in protein extracts for each experimental interval . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Here , we show that Sirt 1 inhibitor , Sirtinol , induced senescence like growth arrest characterized by induction of senescence associated beta galactosidase activity and increased expression of plasminogen activator inhibitor 1 in human breast cancer MCF 7 cells and lung cancer H 1299 cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Raised levels of tissue plasminogen activator and plasminogen activator inhibitor 1 have been found in these patients , and there are reports about hypertension associated with antiretroviral therapy . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Blood coagulation was analyzed at all time points measuring international normalized ratio , platelets , thrombin antithrombin complex , von Willebrand factor , soluble thrombomodulin , d dimers , plasminogen activator inhibitor 1 , and Thrombelastograph analysis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
However , an increase in the expression level of matrix metalloproteinase 2 and 9 , as well as a decrease in plasminogen activator inhibitor 1 expression were observed in arteries exposed to oscillatory shear stress when compared to arteries exposed to unidirectional shear stress . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Quantitative study of left auricle endocardial nitric oxide and plasminogen activator inhibitor 1 mRNA expression in auricular fibrillation in dogs ] . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This increased lipid accumulation was accompanied by enhanced expression of tissue factor and plasminogen activator inhibitor 1 , as well as enhanced thrombin formation , transforming macrophages into a prothrombotic phenotype . ^^^ The LIGHT mediated increase in SR A , tissue factor , and plasminogen activator inhibitor 1 was also seen in human monocyte derived macrophages . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Significant correlations were present between plasma IGF 1 level and plasma triglycerides , plasminogen activator inhibitor 1 activity and Delta 6 desaturase activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Increased expression of plasminogen activator inhibitor 1 in hypoxic renal injury and its pathological significance in progression of advanced renal disease ] . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In human mesangial cells 9 cis RA suppressed TGF beta 1 induced alpha smooth muscle actin , fibronectin , and plasminogen activator inhibitor 1 expression , but it did not significantly affect cell proliferation and survival . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Two day old mice received intracerebral injections of blood in combination with saline or the proteolytic inhibitors hirudin , alpha2macroglobulin , or plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
TGF beta may direct cells to assume a pro fibrotic phenotype or it may do so indirectly after stimulating synthesis of other fibrogenic molecules such as connective tissue growth factor and plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Induction of fibroblast IL 6 expression was accompanied by increased expression of fibronectin and the extracellular matrix regulatory genes plasminogen activator inhibitor 1 and tissue inhibitor of metalloproteinase 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Thus , the activated endothelium promotes the development of the atherosclerotic disease process , i . e . , vascular inflammation and thrombosis by producing vasoconstrictor substances , by inducing the expression of adhesive receptors for leukocytes and platelets , the production of tissue factor and endothelin , and by increasing the production of the plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
C reactive protein , plasminogen activator inhibitor 1 , matrix metalloproteinases and other emerging risk factors and their roles are continually being researched and discovered . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
These include decreased plasminogen activator inhibitor 1 , reduced platelet aggregation , reductions of several vascular adhesion molecules , and reduced markers of low grade inflammation such as C reactive protein . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
RECENT FINDINGS : The prognostic effect of urokinase plasminogen activator and plasminogen activator inhibitor 1 was confirmed in a meta analysis and in a prospective randomized clinical study that provided level 1 evidence for the clinical value of these markers . ^^^ Furthermore , encouraging data suggest that both urokinase plasminogen activator and plasminogen activator inhibitor 1 might be important predictive markers . ^^^ SUMMARY : On the basis of currently available data , tumor urokinase plasminogen activator and plasminogen activator inhibitor 1 levels could already be used in everyday clinical practice for selection of candidates for adjuvant systemic therapy . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This review summarizes our current understanding of coagulation and fibrinolysis in human ALI / ARDS with an emphasis on pathways that could be potential therapeutic targets including the tissue factor pathway , the protein C pathway and modulation of fibrinolysis via plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Role of angiotensin converting enzyme insertion / deletion and plasminogen activator inhibitor 1 4G / 5G gene polymorphisms in retinal vein occlusion . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A number of adipokines , including leptin , adiponectin , tumour necrosis factor alpha , IL 1beta ( interleukin 1beta ) , IL 6 , monocyte chemotactic protein 1 , macrophage migration inhibitory factor , nerve growth factor , vascular endothelial growth factor , plasminogen activator inhibitor 1 and haptoglobin , are linked to inflammation and the inflammatory response . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Urokinase plasminogen activator and plasminogen activator inhibitor 1 are recently validated prognostic markers for lymph node negative breast cancer patients and thus may be of value in selecting node negative patients that do not require adjuvant chemotherapy . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : We tested the effects of alcohol withdrawal in heavy alcohol consumers and compared the plasma levels of endothelin 1 , nitric oxide , plasminogen activator inhibitor 1 , von Willebrand factor , malondialdehyde , and intracellular glutathione with those of alcoholics that did not modify their alcohol intake and teetotalers . ^^^ RESULTS : Alcohol increased the levels of endothelin 1 , nitric oxide , and plasminogen activator inhibitor 1 and decreased the levels of von Willebrand factor both in vivo and in vitro . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In MRT cell lines , reexpression of hSNF 5 induces G 1 cell cycle arrest , elevated p16INK4a , and activated replicative senescence markers , such as beta galactosidase ( beta Gal ) and plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasma plasminogen activator inhibitor 1 concentrations were significantly lower in the DAG oil group . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Incubation of mesangial cells with natural or synthetic PPAR gamma agonists 15 deoxy Delta 12 , 14 prostaglandin J 2 ( 15d PGJ 2 ) or troglitazone and ciglitazone suppressed TGF beta 1 mediated alpha smooth muscle actin , fibronectin , and plasminogen activator inhibitor 1 expression . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
This panel was completed with the measurement of lipoprotein ( a ) , von Willebrand factor , plasminogen activator inhibitor 1 antigen , serum total cholesterin , HDL cholesterin , C reactive protein and PIA 2 variant . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Insulin action , quantified by the insulin suppression test , improved after three months of treatment in both groups , and concentrations of C reactive protein , plasminogen activator inhibitor 1 and Eselectin all fell . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Exposure to 100 500microM H ( 2 ) O ( 2 ) for 10min , as well as exposure to 5 25mU / ml glucose oxidase for 18h , similarly decreased adiponectin , leptin , and resistin mRNAs , and increased plasminogen activator inhibitor 1 mRNA . ^^^ Although a peak increase in plasminogen activator inhibitor 1 mRNA was achieved between 4 and 8h after exposure to H ( 2 ) O ( 2 ) for 10min , significant decreases in adiponectin and resistin mRNA were observed after 16h , while leptin mRNA was decreased earlier . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
RESULTS : Compared to the lean controls , obese Zucker rats showed significant increases in collagen staining , as well as expressions of collagen , fibronectin , plasminogen activator inhibitor 1 , and two major proinflammatory mediators ( i . e . , interleukin 6 and monocyte chemoattractant protein 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In these cultures , specific inhibition of CCL 2 or CCR 2 attenuated the overexpression of alpha SMA , but not CTGF or plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
High sensitive C reactive protein ( hs CRP ) , plasminogen activator inhibitor 1 , monocyte chemotactic protein 1 , interleukin 6 , urine albumin creatinine ratio , hemoglobin A ( 1c ) , total cholesterol , and LDL C were measured at baseline and after 8 and 16 weeks of treatment . ^^^ Plasminogen activator inhibitor 1 , monocyte chemotactic protein 1 , and interleukin 6 were not changed . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A handful of Ag have hitherto been recognized viz . heat shock protein 60 in SLE and leprosy , or plasminogen activator inhibitor 1 in SLE and Wegener granulomatosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
We measured AGE peptides , markers of endothelial dysfunction ( von Willebrand factor , soluble E selectin , plasminogen activator inhibitor 1 , tissue type plasminogen activator , soluble vascular cell adhesion molecule 1 ) and markers of inflammatory activity ( soluble intercellular adhesion molecule 1 , C reactive protein , secretory phospholipase A 2 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Furthermore , LMO 4 can interact with the MH 1 and linker domains of receptor mediated Smad proteins , and associate with the endogenous TGFbeta responsive Plasminogen Activator Inhibitor 1 gene promoter in a TGFbeta dependent manner , suggesting that such interactions may mediate the effects of LMO 4 on TGFbeta signaling . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Increased flux through HBP is required and sufficient for some of the metabolic effects of sustained , increased glucose flux , which promotes the complications of diabetes , e . g . , diminished expression of sarcoplasmic reticulum Ca ( 2+ ) ATPase in cardiomyocytes and induction of TGF beta and plasminogen activator inhibitor 1 in vascular smooth muscle cells , mesangial cells , and aortic endothelial cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The 14 d adaptation period did not affect any of the glycaemic or lipaemic variables but there was a reduction in postprandial plasminogen activator inhibitor 1 concentrations . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The humoral mediators measured were the chemokine IL 8 , plasminogen activator inhibitor 1 , and neutrophil elastase ( NE ) . ^^^ Before DHP PMX treatment , the Acute Physiology and Chronic Health Evaluation 2 score was 24 + / 2 . 0 , the IL 8 level was 54 + / 15 . 8 pg / ml , plasminogen activator inhibitor 1 was 133 + / 28 . 1 ng / ml , and NE was 418 + / 72 . 1 mug / l . ^^^ The mean blood levels of plasminogen activator inhibitor 1 , NE , and IL 8 were significantly decreased from 48 hours after DHP PMX treatment . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Arsenic / TPA treatment resulted in increased expression of alpha fetoprotein , k ras , c myc , estrogen receptor alpha , cyclin D 1 , cdk2na , plasminogen activator inhibitor 1 , cytokeratin 8 , cytokeratin 18 , glutathione S transferases and insulin like growth factor binding proteins in liver and liver tumors from both male and female mice . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
After full mouth tooth extraction , there was a significant decrease in C reactive protein , plasminogen activator inhibitor 1 and fibrinogen , and white cell and platelet counts . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Enhancement of serum MIP 2 and plasminogen activator inhibitor 1 concentrations in LPS / RAN treated rats was prevented by anticoagulation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Transcriptional profiling revealed that aneurysm progression in Fbn 1 null mice is accompanied by unproductive up regulation of gene products normally involved in tissue repair and vascular integrity , such as plasminogen activator inhibitor 1 , activin A , and cysteine rich angiogenic protein 61 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 is a mammalian serpin that binds and regulates the urokinase receptor complex . ^^^ Thrombosis , inflammation , and plaque growth were assessed after treatment with Serp 1 , Serp 1 chimeras , plasminogen activator inhibitor 1 , or unrelated viral serpins in plasminogen activator inhibitor or urokinase receptor deficient mouse aortic transplants . ^^^ Other serpins did not reproduce Serp 1 activity ; plasminogen activator inhibitor 1 increased thrombosis ( p < 0 . 0001 ) , and unrelated viral serpin , CrmA , increased inflammation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In addition , the expressions of molecules involved in MMP activating and inhibitory pathways ( urokinase type plasminogen activator and tissue type plasminogen activator ; TIMP 1 , TIMP 2 , and plasminogen activator inhibitor 1 ) were found to be increased after abdominal irradiation . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
These genes code for extracellular matrix / space [ apolipoprotein D ( apoD ) , decorin , collagen alpha 1 type 1 , collagen alpha 1 type 3 ] and intermediate filament ( vimentin ) proteins , for modulators of neurite outgrowth ( thrombin receptor , plasminogen activator inhibitor 1 , bone morphogenetic protein 4 , annexin 2 and S 100 related protein , clone 42C ) and for a nerve cell transcription factor ( brain finger protein ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
While ATF 3 failed to induce expressions of VEGF and VEGFR , it regulated those of CDK 2 , CDK 4 , p 8 , plasminogen activator inhibitor 1 , integrin alpha 1 , subunit and matrix metalloprotease MMP 13 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Endogenous NO regulates plasminogen activator inhibitor 1 during angiotensin converting enzyme inhibition . ^^^ Neither L arginine nor ramipril alone affected basal plasminogen activator inhibitor 1 or tissue type plasminogen activator ( t PA ) antigen in these salt replete subjects in whom plasma renin activity was suppressed ( mean+ / SD 0 . 7+ / 0 . 5 ng angiotensin I / mL per hour ) . ^^^ In contrast , L arginine+ramipril reduced morning plasminogen activator inhibitor 1 antigen ( 10 . 8+ / 9 . 5 ng / mL ) and the molar ratio of plasminogen activator inhibitor 1 : t PA ( 2 . 3+ / 1 . 6 ) compared with placebo ( 13 . 5+ / 10 . 8 ng / mL , P=0 . 006 ; ratio 2 . 9+ / 2 . 1 , P=0 . 015 ) or ramipril alone ( 15 . 2+ / 13 . 2 ng / mL , P=0 . 009 ; ratio 3 . 7+ / 3 . 3 , P=0 . 005 ) . ^^^ During angiotensin converting enzyme inhibition , endogenous NO decreases plasminogen activator inhibitor 1 antigen and improves fibrinolytic balance in normotensive salt replete subjects . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Indeed , increases in the amount of active urokinase plasminogen activator and its receptor were observed following an IL 4 treatment , while the plasminogen activator inhibitor 1 decreased . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Moreover , the enzyme converted the active plasminogen activator inhibitor 1 to the latent form . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Adipocytokines and incident diabetes mellitus in older adults : the independent effect of plasminogen activator inhibitor 1 . ^^^ We measured the levels of adipocytokines adiponectin , leptin , interleukin 6 , tumor necrosis factor alpha , and plasminogen activator inhibitor 1 . ^^^ Adiponectin , leptin , and plasminogen activator inhibitor 1 attenuated the relationship between adiposity and diabetes . ^^^ After controlling for body mass index , visceral fat , fasting glucose , fasting insulin , high density lipoprotein cholesterol , triglycerides , and hypertension at baseline , plasminogen activator inhibitor 1 was the only adipocytokine independently associated with increased odds of diabetes ( OR , 1 . 35 ; 95 % CI , 1 . 01 1 . 81 ) . ^^^ Plasminogen activator inhibitor 1 may be a useful predictor of diabetes in addition to measurements of body fat . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Based on the gene expression profile , we demonstrated the significant changes of adipocytokine expression ( up regulation of adiponectin and down regulation of plasminogen activator inhibitor 1 and interleukin 6 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Two of the functional clusters included genes regulating extracellular matrix such as connective tissue growth factor , serpine 1 ( plasminogen activator inhibitor 1 ) and TIMP 1 and TIMP 3 , and those involved in cytoskeletal organization and myofibroblast formation including calponins and transgelin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
RESULTS : Compared with subjects with normal glucose tolerance , IGT patients exhibited higher plasma levels / activities of fibrinogen , factor 7 , plasminogen activator inhibitor 1 , high sensitivity C reactive protein , and oxidized low density lipoproteins . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
South Asians have a much higher prevalence of metabolic syndrome , diabetes , insulin resistance ( and resultant hyperinsulinemia ) , central obesity , dyslipidemias ( lower high density lipoprotein , increased lipoprotein [ a ] , higher triglyceride levels ) , increased thrombotic tendency ( increased plasminogen activator inhibitor 1 and decreased tissue plasminogen activator levels ) , decreased levels of physical activity , and low birth weights ( `` fetal origins hypothesis ' ' ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Twelve MetS related traits , including BMI , waist circumference , blood pressure , white blood cell count , fasting serum triglycerides , HDL cholesterol , insulin , glucose , plasminogen activator inhibitor 1 antigen , uric acid , and C reactive protein , were measured and adjusted for covariates , including lifestyle variables . ^^^ RESULTS : Significant genetic correlations were detected among BMI , waist circumference , HDL cholesterol , triglycerides , insulin , and plasminogen activator inhibitor 1 antigen and between uric acid and all of the above variables except insulin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
There were no significant differences between treatments in LDL size , blood pressure , plasma glucose , serum C reactive protein , plasma FVII antigen , FVII activated , fibrinogen , von Willebrand factor , tocopherol or carotenoid concentrations , plasminogen activator inhibitor 1 , creatine kinase or troponin 1 activities , haematology or liver function tests or self reported adverse effects . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
CONCLUSION : Specific genes that were found to be up regulated in this first trimester array ( such as plasminogen activator inhibitor 1 and tissue inhibitor of metalloproteinase 3 ) have been described in preeclampsia . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The abnormalities described so far include circulating antiphospholipid antibodies , increased plasma levels of platelet aggregating agents ( serotonin , thromboxane ) , adhesion molecules ( P selectin , von Willebrand factor ) , antifibrinolytic enzymes ( plasminogen activator inhibitor 1 ) and cytokines . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Expression of components of the plasminogen activator system [ i . e . , urokinase type plasminogen activator ( uPA ) , plasminogen activator inhibitor 1 , and uPA receptor ] was detected in six human pancreatic cancer cell lines . ^^^ Moreover , activation of PPAR gamma by ligands increased plasminogen activator inhibitor 1 and decreased uPA levels in pancreatic cancer cells , and this was accompanied by a reduction in total urokinase activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Conversely , treatment with plasminogen activator inhibitor 1 or neutralizing antibody to uPA blocked Matrigel invasion of 4T1 control cells . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In TK 173 cells , BMP 6 antagonised the TGF beta induced expression of the genes encoding plasminogen activator inhibitor 1 and connective tissue growth factor ( 70 and 50 % reduction , respectively ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Paricalcitol and calcitriol are equally potent at suppressing plasminogen activator inhibitor 1 synthesis and inhibiting cellular proliferation in human coronary artery SMCs . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Glucose deprivation did not increase the levels of gelatinase and plasminogen activator inhibitor 1 secretion , or the expression of cell associated uPA receptor . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Of the four participants , participant 10 had the highest baseline values of prothrombin fragments 1 and 2 , thrombin antithrombin 3 complexes , tissue plasminogen activator , plasminogen activator inhibitor 1 , D dimer and soluble thrombomodulin . ^^^ Over time , in participant 10 , venous prothrombin fragments 1 and 2 , thrombin antithrombin 3 complexes , and soluble thrombomodulin decreased in both limbs ; D dimer decreased in the lower limbs but increased in the upper limbs ; the tissue plasminogen activator / plasminogen activator inhibitor 1 molar ratio increased in both limbs ; and minimal changes were noted in haematocrit . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
These differences include decreased plasma concentrations of plasminogen , tissue type plasminogen activator and alpha 2 antiplasmin , increased plasma concentrations of plasminogen activator inhibitor 1 , as well as a decrease in both plasmin generation and overall fibrinolytic activity . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In addition , the secretion of tissue inhibitor of metalloproteinases ( TIMP 1 and TIMP 2 ) and plasminogen activator inhibitor 1 was significantly decreased by FSH and LH ( 100 or 1 , 000 ng / mL ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Both treatment groups showed significantly reduced infiltrating glomerular macrophages and plasminogen activator inhibitor 1 mRNA expression in cortex , with no change in transforming growth factor beta 1 and tissue inhibitor of metalloproteinase 1 mRNA . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Inhibition of uPA activity with natural ( plasminogen activator inhibitor 1 ) or synthetic ( amiloride ) inhibitors diminished HT hi / diss Matrigel invasion in vitro and intravasation and metastasis in vivo . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The results showed that no significant differences in tissue plasminogen activator levels ( t PA ) ( both antigen and activity ) , plasminogen activator inhibitor 1 levels ( PAl 1 ) ( both antigen and activity ) were observed in control and experimental groups after exercise training for 8 weeks as compared to the baseline . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Importantly , the addition of plasminogen activator inhibitor 1 to the microthrombi suspension completely blunted the heat shock induced acceleration of microvascular recanalization . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS AND RESULTS : Forced expression of KLF 2 in human umbilical vein endothelial cells potently inhibited the ability of thrombin to induce multiple prothrombotic factors ( tissue factor , CD40L , plasminogen activator inhibitor 1 ) , cytokines / chemokines ( eg , monocyte chemotactic protein 1 , interleukin 6 [ IL 6 ] , IL 8 ) , and matrix degrading enzymes ( eg , matrix metalloproteinases 1 , 2 , and 9 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A radical change in perspective followed the discovery of a large number of proteins secreted from white adipocytes , such as leptin , resistin , adiponectin , adipsin , acylation stimulating protein , angiotensinogen , tumour necrosis factor a , interleukin 6 , retinol binding protein , plasminogen activator inhibitor 1 , tissue factor , fasting induced adipose factor , fibrinogen / angiopoetin related protein , and metallothionein . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Matched cohort and case control analyses have shown that VHL 598C > T homozygosity is associated with lower peripheral blood pressures , varicose veins , vertebral hemangiomas , lower white blood cell and platelet counts , and elevated serum concentrations of vascular endothelial growth factor and plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Some researchers believe that additional signs of inflammation such as plasminogen activator inhibitor 1 and C reactive protein should be added to this list . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
The luciferase activities of TMLC cells , Mv1Lu cells stably expressing a portion of the plasminogen activator inhibitor 1 promoter , co cultured with LSc fibroblasts were significantly elevated compared with those co cultured with normal fibroblasts and were significantly reduced in the presence of anti alphavbeta 5 antibody . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Quantitation of Vervet monkey ( Chlorocebus aethiops ) plasminogen activator inhibitor 1 in plasma and platelets . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Increased plasma plasminogen activator inhibitor 1 levels caused by additional aspirin treatment . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor 1 aids nerve growth factor induced differentiation and survival of pheochromocytoma cells by activating both the extracellular signal regulated kinase and c Jun pathways . ^^^ Plasminogen activator inhibitor 1 is one of the active soluble factors released by astrocytes and regulates plasminogen activator plasmin proteolytic sequence in the CNS as a serpin . ^^^ In this study , we show that plasminogen activator inhibitor 1 can promote neurite outgrowth and survival of rat pheochromocytoma cells in serum deprived conditions , and that this neuroprotective activity is correlated with enhanced activation of both extracellular signal regulated kinases following a direct phosphorylation of nerve growth factor receptor , Trk A , and of c Jun . ^^^ Our results suggest that plasminogen activator inhibitor 1 can act as a neurotrophic factor , protecting neurons from serum deprivation induced neuron death not only by compensating for nerve growth factor functions , but also by activating the c Jun / activating protein 1 pathway . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Prothrombin time ( PT ) and activated partial thrombplastin time ( APTT ) , tissue plasminogen activator and plasminogen activator inhibitor 1 , and platelet aggregation rate were determined with a reaction system consisting of mixed fresh normal plasma , in endogenous hypertriglyceridemic ( HTG ) patients , in in vitro modified lipoproteins from a normolipidemic donor , and in experimental rats . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the Asian Indian group , CRP and plasminogen activator inhibitor 1 decreased and adiponectin increased after pioglitazone , but there were no significant changes in total or visceral fat . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
There is also consumption of platelet plasminogen activator inhibitor 1 and increased generation of plasmin in platelets accompanied by proteolysis of stored alpha granule proteins , including Factor 5 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Generation of angiostatin by platelet membranes was not affected by a matrix metalloproteinase ( MMP ) inhibitor , phenanthroline , but was inhibited by serine proteinase inhibitors aprotinin , leupeptin , plasminogen activator inhibitor 1 , and selective inhibitor of urokinase plasminogen activator ( uPA ) , uPA STOP ( TM ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In experimental models , aldosterone has been shown to promote endothelial dysfunction ; induce vascular inflammation , myocardial ischemia , and necrosis ; increase collagen synthesis in cardiac fibroblasts ; contribute to plasminogen activator inhibitor 1 regulation ; decrease baroreceptor sensitivity and reflex function ; block myocardial uptake of norepinephrine ; increase oxidative stress ; and stimulate cardiomyocyte apoptosis . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Among these adipokines are free fatty acids , plasminogen activator inhibitor 1 , angiotensinogen , TNFa , leptin and adiponectin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In 15 patients who had been treated with chronic haemodialysis , we measured and compared platelet aggregation ( induced by adenosine diphosphate , collagen and epinephrine ) , the markers of coagulation and fibrinolysis activation ( thrombin antithrombin complexes , thrombin fragments F1+2 , D dimer ) , and fibrinolytic parameters , i . e . fibrinogen , plasminogen , tissue plasminogen activator ( t PA ) and plasminogen activator inhibitor 1 antigen and activity , before and immediately after the regular haemodialysis sessions . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Another adipose tissue secreted protein , plasminogen activator inhibitor 1 , was identified by ELISA in S 5 cell culture media . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In contrast , in renal carcinoma cells that constitutively express HIF 1alpha and HIF 2alpha due to loss of VHL function , we found that high basal VEGF , glucose transporter 1 , urokinase type plasminogen activator receptor , and plasminogen activator inhibitor 1 expression was predominantly dependent on HIF 2alpha . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
A marked decrease in the plasma levels of plasminogen activator inhibitor 1 ( by 42 % ) and fibrinogen ( by 27 % ) was observed in the acarbose group at the end of the study , whereas no significant changes in the levels of these parameters were observed in the control group . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Conjugated equine estrogen therapy decreased plasminogen activator inhibitor 1 ( placebo 10 CEE : 16 . 33 + / 9 . 11 10 13 . 08 + / 8 . 87 UI / mL , P < . 03 ) and increased factor 8 activity ( 134 . 11 % + / 46 . 18 % 10 145 . 33 % + / 42 . 04 % , P < . 04 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In addition , several active proteins generated in the central adipose tissue , such as leptin , proinflammatory cytokines , plasminogen activator inhibitor 1 , angiotensinogen , and growth factors ( transforming growth factor beta 1 ) , as well as low levels of the protective adiponectin , may contribute to renal injury . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Oral E ( 2 ) decreased plasminogen activator inhibitor 1 activity ( P < 0 . 05 ) . ^^^ Oral E ( 2 ) with NETA reduced plasminogen activator inhibitor 1 antigen levels ( P < 0 . 01 ) and increased D dimer antigen levels ( P < 0 . 001 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Blood concentrations of hs CRP , interleukin 6 , and plasminogen activator inhibitor 1 were higher in diabetic patients with than in those without MS ( P < . 0001 , P = . 0056 , and P < . 0001 , respectively ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Identification of a peroxisome proliferator responsive element ( PPRE ) like cis element in mouse plasminogen activator inhibitor 1 gene promoter . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In the obese group , plasma adiponectin concentrations showed a strong positive association with concentrations of HDL cholesterol ( P < 0 . 0001 ) and negative associations with LDL cholesterol , triglycerides , high sensitivity C reactive protein , interleukin 6 , apolipoprotein B ( 100 ) , soluble E selectin , soluble vascular cellular adhesion molecule 1 , plasminogen activator inhibitor 1 , leukocyte count , and liver and intramyocellular fat ( all P < 0 . 03 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Genotype combinations of plasminogen activator inhibitor 1 and angiotensin converting enzyme genes and risk for early onset of coronary heart disease . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In addition , plasminogen activator inhibitor 1 , vascular endothelial growth factor , angiotensin 2 , and resistin may also be altered by the kidney . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In cultured adipocytes , ceramide , sphingosine , and S1P induced gene expression of plasminogen activator inhibitor 1 , TNF alpha , monocyte chemoattractant protein 1 , interleukin 6 , and keratinocyte derived chemokine . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
U 2 also activates nicotinamide adenine dinucleotide phosphate ( NADPH ) oxidase and plasminogen activator inhibitor 1 in human VSMCs , and stimulates VSMC proliferation with synergistic effects observed when combined with oxidized low density lipoprotein , lysophosphatidylcholine , reactive oxygen species or serotonin . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Insulin sensitivity by intravenous glucose tolerance test and circulating cardiovascular risk factors ( including lipids , tissue plasminogen activator , and plasminogen activator inhibitor 1 ) were measured in a subset ( n = 9 ) . ^^^ There was significant insulin resistance in the subset with metabolic measurements at baseline , and at follow up there was no improvement in fasting glucose , insulin , or insulin sensitivity , nor was there any change in fasting lipids , tissue plasminogen activator , or plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In contrast to TF , DMSO did not affect expression of TF pathway inhibitor or plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Platelet monocyte binding ( a sensitive measure of platelet activation ) and plasma tissue plasminogen activator ( tPA ) , plasminogen activator inhibitor 1 , and von Willebrand factor concentrations were measured at intervals throughout the study . ^^^ In forearm resistance vessels , SFLLRN increased forearm blood flow ( P < 0 . 001 ) , tPA release ( P < 0 . 001 ) , and platelet monocyte binding ( P < 0 . 0001 ) without affecting plasma plasminogen activator inhibitor 1 or von Willebrand factor concentrations . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
Deletion mapping of plasminogen activator inhibitor , type 1 ( PLANH 1 ) and beta glucuronidase ( GUSB ) in 7q21 q 22 . ^^^ The results localize plasminogen activator inhibitor type 1 ( PLANH 1 ) to 7q22 . 1 q22 . 3 and beta glucuronidase to band 7q21 . 11 . . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
In four patients we have previously localized the breakpoints in band 7q22 between the erythropoietin ( EPO ) and plasminogen activator inhibitor type 1 ( PLANH 1 ) genes that map 3 cM apart . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
METHODS : We studied polymorphic markers of genes encoding clotting factors 5 ( F 5 ) and 7 ( F 7 ) , subunit IIIa of platelet integrin ( ITGB 3 ) , beta chain of fibrinogen ( FGB ) and tissue plasminogen activator type 1 ( PLANH 1 ) . ^^^
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00747	Pubmed	SVM Score :0.0
NA