Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Vital signs , EKG tracings and laboratory parameters were monitored before and after the angiographic procedure ; the coagulation screening included : thrombin time , prothrombin time , partial thromboplastin time , euglobulin lysis time , plasma thromboplastin antecedent , and plasminogen activator inhibitor ( PAI ) . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Prothrombin fragment F1+2 , modified antithrombin , PAI and fibrinogen degradation products were not significantly effected . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Therefore , we looked for alterations of fibrinolytic parameters ( tissue plasminogen activator ( t PA ) , tissue plasminogen activator inhibitor ( PAI ) , D dimer , euglobulin clot lysis time ( ECLT ) , plasminogen , alpha 2 antiplasmin ) and of some coagulation parameters ( prothrombin time , fibrinogen , platelets , antithrombin 3 , protein C , factor 12 ) in clearly defined septic patients and for the relations of these values to the severity of the disease ( APACHE 2 score ) . ^^^ The changes in t PA antigen , PAI function , factor 12 , prothrombin time and antithrombin 3 were significantly related to the APACHE 2 score of the patients . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
The purpose of this study was to determine the relationship between the isometric and isokinetic peak torque ( PT ) ( speed of movement 0 , 60 , and 180 deg / s ) and the peak angular impulse ( PAI ) and average power ( AP ) of multiple contractions ( 180 deg / s ) of the quadriceps and hamstrings in 29 patients with a chronic , complete deficiency of the medial collateral ligament ( MCL ) of the knee . ^^^ At every test speed the Pearson product moment ( r ) and the Spearman rank ( rs ) correlation coefficients between the PT and PAI were highly significant for both muscle groups in the uninjured ( r = . 81 . 97 , rs = . 77 . 97 ) as well as in the MCL deficient ( r = . 77 . 97 , rs = . 75 . 95 knees . ^^^ In conclusion , concerning MCL deficient or uninjured knees the PAI or AP analysis may offer little additional information about thigh muscle function to that attained by more simple measurement , the PT analysis . . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
The aim of this study was to determine whether isometric and isokinetic peak torque ( PT ) of hamstring and quadriceps muscles ( speed of movement 0 degrees , 60 degrees , and 180 degrees / sec ) is a valid predictor of peak angular impulse ( PAI ) and average power ( AP ) ( 180 degrees / sec ) in 20 patients after an injury to the lateral collateral ligament ( LCL ) of the knee . ^^^ At every test speed the Pearson product moment ( r ) and the Spearman rank ( rs ) correlation coefficients between the PT and PAI were highly significant for both muscle groups in the uninjured ( r = . 71 . 96 , rs = . 76 . 96 ) as well as in the injured ( r = . 70 . 96 , rs = . 78 . 98 ) knees . ^^^ In conclusion , concerning LCL insufficient or uninjured knees , the PAI or AP analysis may offer little additional information about thigh muscle function to that attained by more simple measurement , the PT analysis . . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
The following factors were studied in the immediate preoperative period , at different surgical times throughout the procedure and 2 3 h after the end of the abdominal sutures : platelet count , prothrombin concentration , fibrinogen , activated kephalin time , factors 2 , 5 , 7 + 10 and VIIIc , antithrombin 3 , protein C , D dimers , fibrinogen and fibrin degradation products ( PDF ) , plasma plasminogen , tissue plasminogen activator ( tPA ) and the fast tPA inhibitor ( PAi ) . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
In control animals , reduced levels of prothrombin , antithrombin , kallikrein inhibitors , antiplasmin , and increased level of plasminogen activator inhibitor ( PAI ) indicated systemic activation of the coagulation , kallikrein kinin , and fibrinolytic systems . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
The following parameters were assayed in arterial blood samples obtained before and after the examination in each patient : platelet markers : beta thromboglobulin ( beta TG ) and platelet factor 4 ( PF 4 ) ; prethrombotic markers : thrombin antithrombin 3 complex ( TAT ) and prothrombin fragments 1 and 2 ( F 1 + 2 ) as well as partial exploration of fibrinolysis : tissue plasminogen activator inhibitors ( PAI ) . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Heat stroke patients showed ( 1 ) significant prolongation of the prothrombin ( PT ) , activated partial thromboplastin ( aPTT ) and thrombin times ( TT ) but normal reptilase time ( RT ) ; ( 2 ) significant reduction in plasma levels of antithrombin 3 ( AT 3 ) , factor 5 , proteins C and S , plasminogen activator inhibitor ( PAI ) and platelet count ; ( 3 ) increase in plasma factor 8 , tissue plasminogen activator ( t PA ) and serum FDP ; ( 4 ) no significant changes in plasma fibrinogen , plasminogen , alpha 2 antiplasmin and factors 7 and 10 . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
The antigen levels of von Willebrand factor ( vWF ) , tissue plasminogen activator ( t PA ) , and its inhibitor ( PAI ) were also determined as markers of release from the endothelium , while the fragment 1 + 2 of prothrombin ( F 1 + 2 ) and thrombin antithrombin 3 ( TAT ) complexes were assessed as indexes of systemic thrombin generation . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
The markers for hemostasis and fibrinolysis were : markers for plasmin generation [ alpha 2 plasmin inhibitor ( alpha 2 PI ) , plasminogen , plasmin alpha 2 PI complex ( PIC ) ] ; markers for fibrinolysis [ fibrin / fibrinogen degradation products E fragment ( FDP E ) , FDP D D dimer ( D dimer ) , fibrinogen ] ; markers for hemostatic activity ( prothrombin time ( PT ) , antithrombin 3 ( AT 3 ) , protein C ) ; markers for thrombin generation [ thrombin antithrombin 3 complex ( TAT ) ] ; markers for intrinsic fibrinolytic activity [ tissue plasminogen activator plasminogen activator inhibitor complex ( TPA PAI complex ) ] . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
PAI 1 complex , prothrombin fragment 1+2 and fibrin degradation product E ( FDP E ) in 40 patients with atrial fibrillation ( Af ) ( 13 males , 27 females , mean age 76 + / 8 yrs ) . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
We measured PT , TT , KPTT , Fg , vWF , AT IIIAg , AT IIIA , alpha 2M , TXB 2 , 6 keto PGF 1 alpha , PLg , tPAAg , tPAA and PAI of patients with acute onset of chronic bronchitis , pulmonary emphysema , and cor pulmonale . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
OBJECTIVE : To establish the plasma evolution of prothrombin fragments 1+2 ( F 1+2 ) , thrombin antithrombin 3 complexes ( TAT ) , fibrin fragment D Dimers ( DD ) , von Willebrand factor antigen ( vWf ) , Type 1 plasminogen activator inhibitor antigen ( PAI ) and blood platelet count during normal pregnancy and to compare these values with those obtained in hypertensive or pre eclamptic pregnancies . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Since thromboembolic complications in transplanted patients are generally attributed to combined abnormalities in platelets and coagulo lytic system , some hemostatic parameters tPA ( tissue plasmogin activator ) : Ag and activity , its inhibitor PAIAg and activity , tPA / PAI , thrombin antithrombin ( TAT ) and plasmin antiplasmin complexes ( PAP ) , urokinase uPA , euglobulin clot lysis time ECLT , fibrinogen , plasminogen , protein C activity , D dimer , prothrombin fragments1+2 ( F1+2 ) , fibrin monomers , fibronectin , lipoprotein a , and von Willebrand factor ( vWF ) , were evaluated using commercially available kits . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
MAIN OUTCOME MEASURES : prothrombin fragment 1 + 2 ( F 1 + 2 ) , thrombin antithrombin 3 ( TAT ) , D dimers ( D D ) , factor 7 activated , plasminogen activator inhibitor ( PAI ) , tissue type plasminogen activator ( t PA ) , plasma albumin . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
With the reagents used , protein S , prothrombin fragment 1 + 2 ( F 1 + 2 ) , D Dimers ( D D ) , plasminogen activator inhibitor ( PAi ) levels could not be determined . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
MAIN OUTCOME MEASURES : Fibrinogen , prothrombin time ( PT ) , coagulant activity of Factor 7 ( F VIIc ) and Factor 7 antigen ( F VIIag ) , and plasminogen activator inhibitor ( PAI ) levels were studied . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
All patients had serial coagulation studies , including prothrombin split products ( F1 / F2 ) , fibrinopeptide A ( FPA ) , protein C ( PC ) , thrombomodulin ( TM ) , tissue plasminogen activator ( t PA ) , plasminogen activator inhibitor ( PAI 1 ) , fibrinopeptide B beta 15 42 ( FPB beta 15 42 ) , haemoglobin and platelet counts determined intra and postoperatively . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Platelet count ( PLT ) , PT , aPTT , fibrinogen ( Fib ) , prothrombin fragment F1+2 , antithrombin ( AT ) , protein C ( PC ) , protein S ( PS ) , factor 13 ( FXIII ) , plasminogen ( PLG ) , plasminogen activator inhibitor ( PA 1 ) , spontaneous platelet aggregation in platelet rich plasma ( PRP SPA ) and in whole blood ( WB SPA ) , and antiphospholipid antibodies ( aPL ) were evaluated . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
STUDY DESIGN : One hundred and seventeen normal pregnant women were investigated in a longitudinal study involving five measurements : blood samples were collected at 10 , 20 , 30 , 36 weeks and on the second day puerperium and were assayed for prothrombin time ( PT expressed in INR ) , activated partial thromboplastin time ( PTT ) , fibrinogen ( FBG ) , antithrombin 3 activity ( AT 3 ) , protein C activity ( PC ) , protein S activity ( PS ) , prothrombin fragments 1+2 ( F1+2 ) , type 1 plasminogen activator inhibitor activity ( PAI ) and tissue plasminogen activator antigen ( t PA ) . ^^^ CONCLUSIONS : The parameters showing the greatest variation during pregnancy were PT , FBG , PS , F1+2 and PAI 1 . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
In 15 patients we investigated coagulation parameters before , during and post CPB , i . e . , fibrinogen , antithrombin ( AT ) 3 , thrombin antithrombin complex ( TAT ) , prothrombin fragments F 1 + 2 ( F 1 + 2 ) , factor ( F ) XIIa , tissue factor ( TF ) , and parameters of the fibrinolytic system , i . e . , plasmin antiplasmin complex ( PAP ) , D dimer , tissue plasminogen activator ( tPA ) , urokinase type plasminogen activator ( uPA ) , and plasminogen activator inhibitor type 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Before surgery platelet number ( PLT ) , fibrinogen ( Fbg ) , prothrombin fragment F 1 + 2 ( F 1 + 2 ) , PAI and whole blood spontaneous platelet aggregation ( WB SPA ) were significantly higher ( p at least < 0 . 0005 ) in patients than in controls , while factor 13 ( F 13 ) was significantly lower ( p at least < 0 . 005 ) . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Multivariate Cox analysis performed to correct these results for relative impact of the uPA system and established prognostic factors showed PAI 1 ( disease free survival : P=0 . 002 , relative risk 1 . 86 ; overall survival : P=0 . 005 , relative risk 1 . 39 ) , pT and pN as independent parameters . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
The results were as follows : In intensive infection with MSOF , PT and APTT increased significantly ; activity of F 2 , F 7 , F 10 and F 12 decreased significantly platelet count and Fn decreased markedly ; concentration of Fg and D Dimer increased significantly ; activity of PAI increased markedly ; activity of t PA and alpha ( 2 ) AP decreased slightly . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
This study reports on the predictive value of some haemostatic factors [ fibrinogen , factor 7 and plasminogen activator inhibitor ( PAI ) ] , a marker of endothelial damage ( soluble thrombomodulin ) and several markers of haemostatic system activation ( factor VIIa , prothrombin fragment 1+2 , thrombin antithrombin complexes and D dimers ) on the incidence of vascular events in male , non diabetic patients with chronic ischaemia of the lower limbs . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
This study compared plasminogen plasma activity , protein C and protein S plasma activities , fibrinogen and fibrin degradation products ( FGDP and FBDP , respectively ) , von Willebrand factor antigen ( vWF Ag ) , prothrombin fragment F1 . 2 , thrombin antithrombin complexes ( TAT ) , tissue plasminogen activator ( tPA ) , and plasminogen activator inhibitor ( PAI ) in 16 patients with PPH and in 16 healthy volunteers . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Blood samples drawn on admission , on four occasions during operation as well as 2 hours after operation and on the first postoperative day in 50 patients undergoing elective LC were analyzed for prothrombin fragment 1+2 ( F1+2 ) , soluble fibrin ( SF ) , D dimer ( DD ) , fibrin degradation products ( FbDP ) , tissue type plasminogen activator ( tPA ) activity and antigen , and plasminogen activator inhibitor ( PAI ) activity and antigen . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
The following coagulation tests were performed before and after near maximum exercise : prothrombin time ( PT ) , partial activated thromboplastin time ( PTT ) , fibrinogen ( FBG ) , antithrombin 3 ( ATIII ) , protein C ( PC ) , protein S ( PS ) , prothrombin fragment 1 + 2 ( F 1 + 2 ) , tissue activator of plasminogen ( t PA ) and its inhibitor ( PAI ) . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Plasminogen activator inhibitor ( PAI ) activity , t PA activity , and prothrombin fragment ( PF ) 1+2 were measured before induction of anesthesia , immediately before aortic clamp release , and 5 minutes and 24 hours after aortic clamp release . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
To investigate the association between the risk of myocardial infarction at a young age and genetic factors thought to be associated with an increased tendency to thrombosis ( the polymorphisms 4G / 5G of the PAI 1 gene , PIA1 / PIA2 of the platelet glycoprotein IIIa , C3550T of the platelet glycoprotein Ib gene , G10976A of the factor 7 gene , C677T of the methylenetetrahydrofolate reductase gene , G1691A of the factor 5 gene , and G20210A of the prothrombin gene ) , we performed a case control study evaluating 200 survivors ( 185 men , 15 women ) of myocardial infarction who had experienced the event before the age of 45 years and 200 healthy subjects with a negative exercise test , individually matched for sex , age , and geographic origin with the cases . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Prothrombotic disorders were found in 8 out of 26 patients with cerebral infarction ( FV Leiden mutation : n = 4 ; protein C deficiency : n = 1 ; FV Leiden mutation + protein C deficiency : n = 2 ; prothrombin mutation G20210A : n = 1 ) and in 13 out of 17 with venous thrombosis ( FV Leiden mutation n = 3 ; protein C deficiency n = 5 ; elevated HRGP + PAI : n = 1 , combined deficiency of AT , protein C and plasminogen : n = 1 ; F 12 deficiency : n = 1 ; lupus anticoagulans n = 1 ; FV Leiden + F 12 deficiency + lupus anticoagulans + PAI : n = 1 ) . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Multivariate analysis considering these proteases / protease inhibitors , in addition to alpha 1 antitrypsin , tissue plasminogen activator , plasminogen , alpha 2 antiplasmin , and antithrombin 3 , and established prognostic parameters revealed that , in addition to surgical curability , pT stage , pN stage , and PAI 1 , c erbB 2 is an independent prognostic factor for overall survival of curatively resected patients ( n = 139 ; P = . 049 ; relative risk , 1 . 54 ; 95 % confidence interval , 1 . 08 to 1 . 67 ) and all patients ( P = . 028 ; relative risk 1 . 33 ; 95 % CI , 1 . 28 to 1 . 38 ) . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Furthermore , EPA E significantly and dose dependently ameliorated coagulation related parameters , including the prothrombin time ( PT ) , activated partial thromboplastin time ( APTT ) , fibrinogen level , and factor 2 , 5 , 7 , 8 , 9 , 10 , 11 , and 12 and antithrombin 3 ( AT 3 ) activities , and fibrinolysis related parameters , including plasminogen , tissue type plasminogen activator ( t PA ) , alpha 2 plasmin inhibitor ( alpha 2 PI ) , and plasminogen activator inhibitor ( PAI ) , and also suppressed ADP or collagen induced platelet aggregation and the cholesterol to phospholipid ( C / P ) molar ratio in platelet membranes at a dose of 0 . 1 g / kg or higher . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
In particular , pravastatin at a dosage of 20 mg / day significantly reduced only fibrinogen levels , while at a dosage of 40 mg / day significantly reduced factor 7 , fibrinogen , prothrombin fragments 1 and 2 , thrombin antithrombin complexes , tissue plasminogen activator antigen ( tPA : Ag ) before venous occlusion ( b . o . ) , inhibitor of plasminogen activator activity ( PAI ) b . o . , PAI activity after occlusion ( a . o . ) , the human autoantibodies against oxidized low density lipoprotein ( LDL ) , and the c fraction of the third component system levels , and significantly increased tPA : Ag a . o . levels . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
The factor 5 ( FV ) G1691A mutation , the prothrombin ( PT ) G20210A variant , the methylenetetrahydrofolate reductase ( MTHFR ) T677T genotype , the plasminogen activator inhibitor ( PAI ) 1 promoter polymorphism , lipoprotein ( Lp ) ( a ) , antithrombin , protein C , and protein S were investigated in 48 childhood patients aged neonate to < 18 years ( median 0 . 5 years ) with spontaneous venous thromboembolism ( SVT ) compared with the carrier status of their first degree family members . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Patients with SIRS presented significantly higher values ( p < 0 . 001 ) for factors related to endothelial damage [ von Willebrand factor ( vWF ) , thrombomodulin , tissue plasminogen activator ( t PA ) , and plasminogen activator inhibitor type 1 ( PAI 1 ) antigen ] , hypercoagulability [ prothrombin fragment 1+2 ( F1+2 ) and thrombin antithrombin complexes ( TAT ) ] , and fibrinolysis ( D dimer and PAI activity ) with respect to the control group . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
METHODS : The PAI 1 4G / 4G genotype and the coinheritance with lipoprotein ( Lp ) ( a ) levels , the factor 5 ( FV ) G1691A mutation , the prothrombin ( PT ) G20210A variant , and the methylene tetrahydrofolate reductase ( MTHFR ) T677T genotype were studied in 198 Caucasian children with stroke and 951 controls ( same age , sex and ethnical distribution ) . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
The pathogenesis of antiphospholipid antibody ( aPL ) related thrombosis is multifactorial and includes , amongst others , enhanced coagulation activation measured as prothrombin fragment 1 + 2 ( F 1 + 2 ) , elevated plasma levels of von Willebrand factor ( vWF ) , plasminogen activator inhibitor ( PAI ) and endothelin 1 ( ET 1 ) as well as heightened thromboxane generation and lipid peroxidation . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Kaolin partial thromboplastin time ( KPTT ) , prothrombin time ( PT ) , fibrinogen content , vWF content were analyzed , and tissue plasminogen activator ( t PA ) activity , plasminogen activator inhibitor ( PAI ) activity , D dimer level were assayed . ^^^ There were no significant changes of PT and PAI activity in both groups . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Platelet count , fibrinogen level , prothrombin time , activated partial thromboplastin time , tissue plasminogen activator ( t PA ) activity , plasminogen activator inhibitor ( PAI ) activity , prothrombin fragment ( PF ) 1+2 level , and D dimer level were measured before surgery . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
METHODS : Fifty seven cases of AICVD were grouped and treated with heparin and Xueshuantong ( XST ) respectively , and the levels of prothrombin time ( PT ) , activated partial thromboplastin time ( APTT ) , fibrinogen ( FIB ) , tissue plasminogen activator ( t PA ) , plasminogen activator inhibitor ( PAI ) and activated protein C ( APC ) were determined before and after treatment . ^^^ In the heparin group , level of PT and APTT prolonged , FIB decreased , t PA activity elevated and PAI activity lowered , and APC unchanged . ^^^ In the XST group , same changes in FIB , t PA and PAI were shown but with APC increased , and PT and APTT unchanged . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
INTERVENTIONS : The prothrombotic response to cardiac surgery with CPB was assessed by measuring plasma levels of prothrombin fragment 1 + 2 and plasminogen activator inhibitor ( PAI ) activity . ^^^ MEASUREMENTS AND MAIN RESULTS : After cardiac surgery , prothrombin fragment 1 + 2 levels increased 6 fold and PAI activity increase 2 to 3 fold ( p < . 0001 ) . ^^^ Lactate levels were not associated with prothrombin fragment 1 + 2 and PAI activity levels after CPB . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
PATIENTS AND METHODS : The in vivo effect of PGE 1 on the fibrinolytic and hemostatic process was tested on 15 patients before and after treatment with Alprostadil for 21 days using D dimers ( DD ) , fibrinogen , prothrombin time ( PT ) , partial thromboplastin time ( PTT ) , antithrombin ( AT ) , ProC Global , plasminogen , plasminogen activator inhibitor activity ( PAI ) , alpha 2 antiplasmin , coagulation factor 12 , basal and activated fibrinolytic capacity ( fib . cap . ) . ^^^ RESULTS : There was no significant difference in DD , fibrinogen , PT , PTT , AT , ProC Global , plasminogen , PAI , alpha 2 antiplasmin , coagulation factor 12 , basal and activated fibrinolytic capacity observed after the treatment . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Levels of D dimer ( DD ) , thrombin antithrombin complex ( TAT ) , prothrombin fragment 1+2 ( F1+2 ) , von Willebrand factor ( vWF ) , fibrinogen , tissue plasminogen activator ( TPA ) and activity of its inhibitor ( PAI ) , soon after start of treatment with heparins and in 1 , 3 , 7 and 14 days . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Repeated measurements of estradiol , progesterone , prothrombin time ( PT ) expressed as INR , activated partial thromboplastin time ( APTT ) ratio , fibrinogen ( FBG ) , factor 8 ( FVIII ) , normalized activated protein C ratio ( nAPC ratio ) , antithrombin 3 activity ( AT ) , protein C activity ( PC ) , protein S activity ( PS ) , tissue type plasminogen activator antigen ( t PA ) , type 1 plasminogen activator inhibitor ( PAI ) , prothrombin fragments 1+2 ( F1+2 ) , were performed during both hyperstimulated and natural cycles , and at onset of the following menstruation or at 8 weeks of pregnancy . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Forty five diabetic patients and forty five matched controls were evaluated by doing the following haemostatic parameter , prothrombin time , partial thromboplastin time , thrombin time , coagulation factors assay 2 , 7 , 9 , & plasma fibrinogen , ADP induced platelet aggregation , protein C , alpha 2 antiplasmin , PAI and FDPs . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Treatment with all four OCs caused an increase in levels of fibrinogen , prothrombin fragment 1+2 , D dimer , plasminogen , plasmin antiplasmin complex and an increase in protein C activity , a decrease in antithrombin activity , tissue plasminogen activator ( t PA ) and plasminogen activator inhibitor ( PAI ) , and a slight decrease in the sensitivity to activated protein C , but no significant change in that of the thrombin antithrombin complex . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Platelet count , fibrinogen , clotting times , prothrombin fragment ( PF ) 1+2 , and tissue plasminogen activator ( t PA ) and plasminogen activator inhibitor ( PAI ) activities were measured preoperatively , immediately before , and 5 min and 24 hr after aortic declamping . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Prothrombin fragment ( PTF ) 1 + 2 and plasminogen activator inhibitor ( PAI ) activity were measured , and levels correlated with postoperative measures of organ function including the left ventricular stroke work index , the Pao ( 2 ) / fraction of inspired oxygen ( Fio ( 2 ) ) ratio , and creatinine levels . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
MATERIAL AND METHODS : The incidence of the following factors was studied in 97 pregnant women with pregnancy complications and in 103 controls : R506Q mutation encoding Factor 5 Leiden [ FVL ] synthesis , Prothrombin G20210A mutation , T 677 methylenetetrahydropholate reductase mutation [ MTHFR ] , 4G / 4G polymorphism of the plasminogen activator inhibitor [ PAI 4G / 4G ] . ^^^ Prothrombin G20210A carriers were 11 % ( 11 / 97 ) of the studied and 3 . 8 % ( 4 / 103 ) of the controls , while with PAI 4G / 4G polymorphism they were 30 . 9 % ( 30 / 97 ) and 14 . 5 % ( 15 / 103 ) respectively . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
In vitro platelet aggregation induced by collagen and ADP , and variables of coagulation ( factor 7 amidolytic activity and concentrations of fibrinogen and prothrombin fragment 1 and 2 ) and fibrinolysis [ plasminogen activator inhibitor ( PAI ) activity and concentrations of tissue plasminogen activator ( tPA ) / PAI 1 complexes ] did not differ among the 3 diets . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
At baseline , on days 1 , 3 , 7 and 14 ( 7 days after thienopyridines discontinuation ) we measured ADP induced and spontaneous platelet aggregation ( PA ) , levels of prothrombin fragment 1+2 ( F1+2 ) , thrombin antithrombin complex ( TAT ) , von Willebrand factor ( vWF ) , fibrinogen , tissue type plasminogen activator antigen ( tPA ) , plasminogen activator inhibitor activity ( PAI ) and D dimer ( Dd ) , and counted platelet number . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
The following coagulation tests were performed before and after maximal exercise : prothrombin time ( PT ) , partial activated thromboplastin time ( PTT ) , fibrinogen ( FBG ) , antithrombin 3 ( ATIII ) , protein C ( PC ) , protein S ( PS ) , prothrombin fragment 1+2 ( F1+2 ) , tissue activator of plasminogen ( t PA ) and its inhibitor ( PAI ) . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Blood samples were collected at 1 , 2 , 4 , 6 , 8 and 12 hours after administration to assay prothrombin activity , partially activated thromboplastin time , and the activation to tPA and PAI 1 . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Recurrent postoperative bleeding in a previously healthy man with a moderate prolongation of PT and PTT which did not correct with vigorous fresh frozen plasma infusion was identified as a unique abnormality of the fibrinolytic system : a combination of an excess of tissue plasminogen activator ( t PA ) at 300 % of normal activity accompanied by a concurrent deficiency of plasminogen activator inhibitor 1 activity ( PAI 1 ) of 10 20 % of normal activity . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Prothrombin time , activated partial thromboplastin time , fibrinogen , antithrombin 3 , tissue type plasminogen activator ( tPA ) activity , plasminogen activator inhibitor type 1 ( PAI 1 ) activity , and platelet aggregation were measured and compared to those in an age matched control group ( C , n = 7 ) . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
The following parameters were evaluated : tissue plasminogen activator ( t PA ) , plasminogen activator inhibitor ( PAI 1 ) , euglobulin lysis time ( ELT ) , plasminogen , alpha 2 antiplasmin , prothrombin time ( PT ) , activated partial thromboplastin time ( aPTT ) , thrombin clotting time ( TCT ) , and fibrinogen . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
The purpose of this study is to further investigate physiologic changes in plasma coagulation fibrinogenolysis and fibrinolysis in the utero placental circulation in normal pregnancy , labor and puerperium , employing newly developed molecular markers for coagulation fibrinogenolysis and fibrinolysis such as prothrombin fragment 1 + 2 ( F1 . 2 ) , active PAI 1 , Fgfr and Fbfr . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Plasma was assayed for clotting and fibrinolytic activity by measuring thrombin / antithrombin complexes ( TAT ) , prothrombin fragment 1 + 1 ( F 1 + 2 ) , and D dimers ( D di ) ; markers of the endothelial based fibrinolytic components were assayed by measuring tissue plasminogen activator antigen ( t PA Ag ) and its inhibitor ( PAI 1 ) ; finally , the activity of antithrombin 3 , protein C , and protein S were measured . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Holter ST segment recording and pretreatment plasma tissue type plasminogen activator ( t PA ) antigen , plasminogen activator inhibitor 1 ( PAI 1 ) antigen , prothrombin fragment F 1 + 2 and soluble fibrin levels were measured in 57 patients with acute evolving myocardial infarction . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
To investigate further the activation status of the two systems , levels of thrombin antithrombin complexes ( TAT ) , prothrombin fragment 1 + 2 , protein C , total and free protein S , C4bBP , antithrombin 3 , t PA , PAI 1 and D dimer were measured . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
There was no modification of PT , PTT , prothrombin fragment 1 + 2 ( F 1 + 2 ) , fXIIC , tPA , PAI 1 , D dimer or protein S levels ; serum levels of tumor necrosis factor alpha were also unchanged . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Plasma D dimers ( one ELISA and two latex assays ) , fibrin monomer , prothrombin fragment 1 + 2 ( F1+2 ) , thrombin antithrombin 3 complex ( TAT ) and the t PA PAI 1 complex were all significantly correlated to the extension of DVT , whilst fibronectin , tissue type plasminogen activator ( t PA ) , single chain urokinase type plasminogen activator ( scru PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) were not . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Arterial and coronary sinus blood were sampled concomitantly before cardioplegia and after release of the aortic cross clamp , for measurement of t PA antigen ( Ag ) and activity , plasminogen activator inhibitor ( PAI 1 ) Ag and activity , t PA / PAI 1 complex , single chain urokinase ( sc uPA ) and urokinase ( uPA ) plasminogen activators , the fibrin split product D dimer , thrombin antithrombin complex ( TAT ) , and the prothrombin split product F 1 + 2 . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Plasma levels of antithrombin 3 ( AT 3 ) , protein C ( PC ) , plasminogen ( Pg ) and alpha 2 antiplasmin ( AP ) , total and free protein S ( PS ) , thrombin antithrombin 3 complex ( TAT ) , F1 . 2 fragment of prothrombin ( F1 . 2 ) , fibrinogen ( Fg ) , soluble fibrin monomers ( FM ) , tissue plasminogen activator ( t PA ) , plasminogen activator inhibitor 1 ( PAI 1 ) , total fibrinogen / fibrin degradation products ( TDP ) and D dimer ( DD ) were determined prior to the therapeutic regime , at the end of the treatment , and 24 hours later . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Levels of prothrombin fragments 1+2 ( F1+2 ) , tissue plasminogen activator antigen ( t PA ) , plasminogen activator inhibitor 1 activity ( PAI 1 ) , D dimer and interleukin 6 ( IL 6 ) were measured in arterial ( AB ) and mixed venous blood ( MVB ) in five patients during and after total hip replacement operation with acrylic cement prosthesis fixation . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
In order to establish a link between cytokines and the hemostatic changes the following parameters were determined in 44 patients with cirrhosis ( alcoholic = 15 , postnecrotic = 22 , others = 7 ) : TNF alpha , IL 6 , thrombin antithrombin ( TAT ) complexes , prothrombin fragment 1 + 2 ( F 1 + 2 ) and t PA by using enzyme linked immunosorbent assays , and PAI 1 , plasminogen and alpha 2 antiplasmin ( alpha 2 AP ) by using chromogenic substrates . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
FBG was measured by the thrombin time method , FVII activity ( FVIIc ) by the chromogenic prothrombin time method , and t PA and PAI 1 activity by the chromogenic substrate assay . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Plasma levels of selected coagulation and fibrinolytic parameters ( activated partial thromboplastin time , prothrombin time , fibrinogen , antithrombin 3 , protein C , thrombin anti thrombin 3 complexes ( TAT ) , plasminogen activator inhibitor 1 ( PAI 1 ) , plasminogen , alpha 2 plasmin inhibitor ) were evaluated in 90 patients with clinical suspicion of pulmonary embolism ( PE ) . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
In plasma samples of 38 patients ( median age : 49 years ) receiving CMF ( schedule 1 21 or 1 8 ) for Stage 2 breast cancer , we evaluated : PT , aPTT , antithrombin 3 ( AT 3 ) , protein C ( PC ) , protein S ( PS ) , thrombin antithrombin complex ( TAT ) , prothrombin fragment F 1 + 2 ( F 1 + 2 ) , fibrinogen ( Fbg ) , tissue type plasminogen activator ( t PA ) , plasminogen activator inhibitor ( PAI 1 ) and D dimer ( D D ) . ^^^ PT , aPTT , and Fbg were determined with routine methods ; AT 3 , PC , and PS were measured with coagulative tests ; PC and PS were also evaluated with immunoenzymatic methods , t PA , PAI 1 , D D , TAT , and F 1 + 2 were measured with immunoenzymatic methods . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
METHODS : Fourteen patients undergoing laparoscopic cholecystectomy and 12 patients undergoing open cholecystectomy had blood taken in the perioperative period for fibrinopeptide A ( FPA ) prothrombin fragment F1 . 2 , antithrombin 3 , tissue plasminogen activator ( tPA ) and its fast acting inhibitor plasminogen activator inhibitor 1 ( PAI 1 antigen and activity ) , and the euglobulin clot lysis time ( ECLT ) . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Patients receiving CyA had significantly higher concentrations of plasma fibrinogen ( P < 0 . 05 ) , prothrombin fragment 1 + 2 ( F 1 + 2 ; P < 0 . 05 ) , plasminogen activator inhibitor 1 ( PAI 1 ; P < 0 . 05 ) , and von Willebrand factor antigen ( P < 0 . 05 ) than did patients not taking CyA . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
METHODS : We measured the coagulation activation marker prothrombin fragment F 1 + 2 ( F 1 + 2 ) , fibrinogen , plasminogen activator inhibitor 1 activity ( PAI 1 ) , interleukin 6 ( IL 6 ) , insulin , lipids and lipoprotein ( a ) ( Lp ( a ) ) , in 12 patients with chronic renal disease before and after gemfibrozil . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
In addition to routine coagulation tests , antithrombin 3 , von Willebrand factor ( vWF ) , prothrombin fragment 1+2 ( F1+2 ) , thrombin antithrombin complex ( TAT ) , D dimer ( DD ) , and plasminogen activator inhibitor type 1 ( PAI 1 ) were measured in the plasma at the time of diagnosis and as soon as remission was achieved after therapy with plasma exchange and Iloprost . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Coagulation was explored by standard clotting tests and by measurement of prothrombin complex factors , factor 8 ( 8 : C ) and antithrombin 3 ( ATIII ) , protein C ( PC ) and protein S ( PS ) activities , while fibrinolytic potential was evaluated using D dimer , tissue plasminogen activator ( t PA ) and plasminogen activator inhibitor ( PAI 1 ) assays . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Quantitative measurement of plasma concentrations of tissue t PA , t PA PAI 1 complex , alpha 2 antiplasmin plasmin complex ( alpha 2 APP ) , fibrinogen degradation products ( FbDP ) , D dimers ( D D ) , thrombin antithrombin complex ( TAT ) and prothrombin fragment ( F 1 + 2 ) complexes , using double antibody sandwich enzyme linked immunosorbent assays and grading of the degree of hepatic insufficiency according to the Child Pugh classification , were also carried out . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Levels of prothrombin fragments 1 + 2 , D dimers , plasminogen , alpha 2 antiplasmin , tissue plasminogen activator ( tPA ) , and plasminogen activator inhibitor ( PAI 1 ) in venous blood were investigated just before the operation , at the end of the operation and three hours later . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Plasma levels of fibrin D dimer , thrombin antithrombin complex ( TAT ) , plasmin plasmin inhibitor complex ( PPIC ) , soluble fibrin monomer ( sFM ) , prothrombin activated peptide F 1 + 2 ( F 1 + 2 ) , thrombomodulin ( TM ) , tissue type plasminogen activator ( t PA ) , and PA inhibitor ( PAI 1 ) in DIC patients were significantly higher than levels in Non DIC patients . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Some coagulative and fibrinolytic parameters ( PT ; aPTT ; fibrinogen ; euglobulin lysis time ; t PA ; PAI 1 ; ATIII ; alpha 2 antiplasmin ; D Dimer and platelets count ) were assayed at the beginning and at the end of the study . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
We investigated the usefulness of the fluorogenic prothrombin time ( FPT ) for detection of hypercoagulability and its association with hyperlipidemia in 19 patients with non insulin dependent diabetes mellitus ( NIDDM ) and 10 healthy control subjects , compared with plasma levels of fibrinogen , plasminogen activator inhibitor 1 ( PAI 1 ) and D dimer . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
All subjects were tested on the following parameters : fibrinogen , factor 7 , prothrombin fragment 1 + 2 ( F 1 + 2 ) , thrombin antithrombin 3 complexes ( TAT ) , tissue plasminogen activator ( t PA ) antigen ( Ag ) before and after venous occlusion ( VO ) , and plasminogen activator inhibitor type 1 ( PAI 1 ) activity pre and post VO . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
RESULTS : In multivariate analysis considering all the established risk factors , disease free survival was independently predicted by PAI 1 ( relative risk 2 . 21 , 1 . 32 3 . 73 ) and cathepsin D ( relative risk 2 . 98 , 1 . 28 6 . 91 ) besides pT , pN , and extended resection . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Coagulative and fibrinolytic parameters ( PT , aPTT , euglobulin lysis time , fibrinogen , D dimer , t PA , PAI 1 ) and signs and symptoms ( cramps , paresthesia , itch , edema , local pain , skin trophism ) were assessed at enrollment , 15 days later after the pharmacological washout period and after 1 , 2 , 3 months of treatment . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Blood samples were collected from the circuits before the start of the perfusion and at 0 . 5 , 1 , 3 , 12 , and 24 h of perfusion , and analysed for platelet count , plasma betathromboglobulin ( beta TG ) , platelet membrane glycoprotein ( GP ) Ib and GPIIb / IIIa expression , thrombin / antithrombin 3 complex ( TAT ) , prothrombin fragment 1+2 ( F1+2 ) , fibrinogen , D dimer , and plasminogen activator inhibitor 1 activity ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
METHODS : We studied the coagulation cascade , natural clotting inhibitors , fibrinolytic proteins and resistance to activated protein C in 20 patients with advanced gastrointestinal cancer and 84 volunteers by measuring PT , APTT , fibrinogen , AT 3 , PC , PS , APC resistance , fibrinolytic system ( PLG , ANPL , PAI 1 , and t PA ) and activation peptides ( D Dimers , prothrombin 0 fragment 1 + 2 / F1 + 2 ) . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Fibrinogen ( 13 % ) and plasminogen activator inhibitor 1 ( PAI 1 ) concentrations ( 26 % ) decreased , but there were no changes in thrombotic markers including thrombin antithrombin 3 complex , prothrombin fragment 1 . 2 , D dimer , antithrombin activity , protein C and S and von Willebrand factor antigen . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
MEASUREMENTS AND MAIN RESULTS : Blood samples were analyzed for tissue plasminogen activator ( TPA ) activity , TPA antigen , plasminogen activator inhibitor 1 ( PAI 1 ) activity , prothrombin complex F1 . 2 , and antithrombin 3 ( AT 3 ) at the following times : before cardiopulmonary bypass ( CPB ) , during CPB ( 30 and 60 minutes ) , post CPB , and day 1 postsurgery . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Plasma concentrations of plasminogen activator inhibitor ( PAI 1 ) , prothrombin fragment F1+2 , fibrinogen , and von Willebrand Factor ( vWF ) activity were measured . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Median levels of both uPA and PAI 1 showed significant correlation with tumor pT , pN , and pM categories , whereas the presence of lymphatic invasion correlated only with the uPA content and tumor grade correlated only with PAI 1 content . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
In particular , we describe tissue factor , tissue factor pathway inhibitor , prothrombin fragment 1 . 2 , thrombin antithrombin complex , fibrinopeptide A , tissue plasminogen activator ( t PA ) , plasminogen activator inhibitor 1 ( PAI 1 ) , t PA PAI complex , Bbeta 15 42 related peptides , fibrinogen degradation products , fibrin degradation products , D dimer , platelet factor 4 , beta thromboglobulin , 5 hydroxytryptamine , thromboxane B 2 , prostacyclin , endothelin , angiotensin converting enzyme , soluble thrombomodulin , C 1 esterase inhibitor , anaphylotoxins C3a , C4a , and C5a , bradykinin , tumor necrosis factor , leukotriene C 4 , platelet activating factor , anti phospholipid antibody , and von Willebrand factor . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
In both groups the activated partial thromboplastin time ( APTT ) , prothrombin ratio ( INR ) , fibrinogen , euglobulin lysis time ( ELT ) , platelet number and platelet adhesion and aggregation , tissue plasminogen activator antigen ( t PA Ag ) and activity of plasminogen activator inhibitor ( PAI 1 ) were tested and compared . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
The more outstanding polymorphisms in genes of factors involved in coagulation and fibrinolysis described in the literature ( such as fibrinogen , factor 13 , glycoprotein IIb / IIIa , von Willebrand factor , factors 7 , 8 and 9 , factor 5 , ATIII and protein C system factors , prothrombin , PAI 1 and fibrinolytic system ) are reviewed in the context of factor ' s structure and function and also in its proposed relevance for thrombotic and atherothrombotic risk definition . . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
The effects of plateletpheresis on plasma levels of prothrombin fragment ( F ( 1+2 ) ) , D dimer , plasmin plasmin inhibitor ( PPI ) complexes , and plasminogen activator inhibitor ( PAI 1 ) ; on the activation of neutrophils ( % L selectin+ ) ; and on the frequency of platelet neutrophil aggregates ( % CD41+ neutrophils ) were compared . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Prothrombin fragment 1+2 ( F1+2 ) , thrombin antithrombin 3 complexes ( TAT ) , tissue type plasminogen activator ( t PA ) functional and antigen , plasminogen activator inhibitor 1 ( PAI 1 ) , plasminalpha 2 antiplasmin complexes ( PAP ) , D Dimer , thrombomodulin ( TM ) and von Willebrand factor ( vWF ) were measured in patients and in 30 healthy subjects . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
The relationship of mutations in the MTHFR , prothrombin , and PAI 1 genes to plasma levels of homocysteine , prothrombin , and PAI 1 in children and adults . ^^^ Studies in adults have demonstrated that the genetic mutations C677T methylenetetrahydrofolate reductase ( MTHFR ) , prothrombin 20210A , and the 4G polymorphism of the plasminogen activator inhibitor 1 ( PAI 1 ) gene are associated with elevated plasma levels of homocysteine . prothrombin and PAI 1 , respectively and with an increased risk of thrombosis . ^^^ Therefore , we assessed the relationship of plasma levels of homocysteine , prothrombin and PAI 1 with their respective mutations in 197 normal children , compared to 40 adults . ^^^ By stepwise multiple regression , homocysteine was positively associated with age , PAI 1 activity was negatively associated with age , while PAI 1 antigen and prothrombin levels were associated with gender , being higher in girls than boys . ^^^ Studies of the incidence of the MTHFR , prothrombin , and PAI 1 4G / 5G genotypes in children with thrombosis , when compared to these healthy normals , will provide evidence as to which of these genes are associated with thrombophilia . . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
In stable patients ( n = 40 ; 39 males 1 female ; 51 74 years old ) who previously had undergone coronary artery revascularization ( 1 10 years ) , no alterations in prothrombin time , international normalized ratio ( INR ) , prothrombin fragment 1 . 2 , or the hemostatic risk factors factor 7 antigen and coagulant activity , von Willebrand ' s factor , fibrinogen , tPA , or PAI 1 were associated with the 1 mg daily warfarin treatment . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
The fasting insulin concentration was correlated inversely with HDL cholesterol and directly with the fasting triglyceride concentration , blood pressures , plasminogen activator inhibitor 1 ( PAI 1 ) , and tissue plasminogen activator ( tPA ) , but it was not correlated with LDL cholesterol , apolipoproteins B and A 1 , lipoprotein ( a ) , ( Lp ( a ) ) , fibrinogen , factor VIIc , or prothrombin fragment ( F ) 1 + 2 . ^^^ Indians had lower HDL cholesterol , and higher PAI 1 , tPA , and Lp ( a ) , but not higher LDL cholesterol , fasting triglyceride , blood pressures , fibrinogen , factor VIIc , or prothrombin F 1 + 2 . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
We have tried to answer this question by measuring DNA polymorphisms of selected cardiovascular risk indicators [ factor 7 , FVII ( R / Q353 , intron 7 ( 37bp ) n , and 323ins10 ) , beta fibrinogen ( 455G / A ) , plasminogen activator inhibitor type 1 , PAI 1 ( 675 ( 4G / 5G ) ) , tissue plasminogen activator , t PA ( intron 8 ins 311 ) , platelet receptor glycoprotein IIb / IIIa , GPIIb / IIIa ( L / P33 ) , prothrombin ( 20210G / A ) , methylene tetrahydrofolate reductase , MTHFR ( A / V114 ) , angiotensin converting enzyme , ACE ( intron 16 ins 287 ) , and angiotensinogen ( M / T235 ) ] . ^^^ The frequencies of the high risk alleles in centenarians were : for FVII R / Q353 0 . 91 ; for FVII intron 7 ( 37bp ) n 0 . 67 ; for FVII 323 ins 10 0 . 90 ; for fibrinogen 0 . 16 ; for PAI 1 0 . 52 ; for t PA 0 . 59 ; for GPIIb / IIIa 0 . 16 ; for prothrombin 0 . 008 ; for MTHFR 0 . 33 ; for ACE 0 . 52 ; and for angiotensinogen 0 . 36 . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
DEVELOPMENT : The conditions related to increased risk of thrombosis are : the congenital thrombophilias due to deficiency of protein C , protein S or antithrombin 3 , resistance to protein C activated by Leiden ' s factor 5 cofactor of protein C with genetic mutation ; the primary antiphospholipid syndrome with anticardiolipin antibodies and lupus inhibitor ; platelet disorders , deficit of heparin cofactor 2 , deficit of plasminogen and plasminogen tissue activator ( t PA ) and increase in the inhibitor of plasminogen tissue activator ( PAI 1 ) ; alterations in factors of coagulation such as deficits of factor 7 and factor 13 , mutation of prothrombin 20210 > A , increase in factor 8 . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
METHODS : Fibrinogen , prothrombin fragment F1+2 , D dimer , and plasminogen activator inhibitor type 1 ( PAI 1 ) activity was determined in 10 patients who underwent open ( group A ) and 10 patients who underwent VLPS cholecystectomy ( group B ) , respectively . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Parameters monitored included blood loss , prothrombin F1 . 2 , thrombin antithrombin complexes , t PA , PAI 1 , plasminogen , fibrin D dimer , and plasma factor 13 . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
However , higher hypercoagulation evidenced by significantly raised prothrombin formation and clot elasticity together with higher levels of D dimer , uPA antigen and PAI 1 than observed in normal pregnancy suggests a hyperfibrinolytic / inhibitor state in hydrops fetalis pregnancy associated with bad obstetric outcome . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Body weight , total serum cholesterol , triacylglycerol , glucose , insulin and HbA1c concentrations , platelet count and aggregation function , prothrombin time , partial thromboplastin time , fibrinogen and PAI 1 concentration , and other routine blood analysis did not change significantly when given the PO diet . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Plasma fibrinogen , antithrombin 3 , von Willebrand factor , tissue plasminogen activator ( tPA ) , plasminogen activator inhibitor 1 ( PAI 1 ) prothrombin time , and activated partial thromboplastin time were determined using standard methods . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
However , no significant differences between the two periods were seen in factor 7 coagulant activity ( FVIIc ) , fibrinogen , prothrombin fragments 1+2 ( F1+2 ) , tissue plasminogen activator ( tPA ) plasminogen activator inhibitor 1 ( PAI 1 ) or 2 , 3 , dinor thromboxane B 2 . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Four gene mutations ( factor 5 Leiden , methylenetetrahydrofolate reductase [ MTHFR ] , prothrombin , and 4G / 5G polymorphism of the plasminogen activator inhibitor type 1 [ PAI 1 ] gene ) were assessed by polymerase chain reaction ( PCR ) . ^^^ The gene mutation group included those with at least 1 thrombophilic mutation ( heterozygous for factor 5 Leiden , heterozygous for prothrombin , and homozygous for MTHFR ) , or hypofibrinolysis with homozygosity for the 4G polymorphism of the PAI 1 gene . ^^^ The non gene mutation group included those with no mutation for all 4 genes ( wild type normal ) or who were wild type normal for the prothrombin and factor 5 Leiden mutations and heterozygous for MTHFR and / or 4G / 5G for the PAI 1 gene , neither heterozygosity associated with coagulation abnormalities . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Plasma levels of : von Willebrand Factor ( vWF ) , thrombomodulin , plasminogen activity inhibitor type 1 ( PAI 1 : antigen and activity ) , tissue type plasminogen activator ( t PA : antigen ) , prothrombin fragment 1+2 ( F1+2 ) and thrombin antithrombin complexes ( TAT ) were measured previously to CRRT ( base line ) , and after 24 and 48 hours of therapy . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
To investigate whether HRT use induces a procoagulant state , we undertook a prospective cohort study in postmenopausal women to investigate the effects of 3 months of treatment with oral HRT ( conjugated equine estrogen 0 . 625 mg daily and medroxyprogesterone 2 . 5 mg daily ) on markers of thrombin generation ( prothrombin fragment 1+2 , thrombin antithrombin complexes ) , fibrinolytic potential ( plasminogen activator inhibitor 1 ( PAI 1 ) activity ) , and activated protein C ( APC ) resistance . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Blood samples were collected at the beginning and at the end of each dietary period from fasted subjects for determination of factor 7 coagulant activity ( FVIIc ) , activated factor 7 ( FVIIa ) , factor 7 antigen ( FVIIag ) , tissue plasminogen activator ( tPA ) activity , plasminogen activator inhibitor type 1 ( PAI 1 ) activity , fibrinogen , prothrombin fragment 1+2 ( F ( 1+2 ) ) , and plasma lipids . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
MATERIALS AND METHODS : In sixty eight peri and postmenopausal women qualified for hormone replacement therapy under study some coagulation and fibrinolysis parameters were measured in serum platelet count , prothrombin time , prothrombin ratio , INR , APTT , thrombin time ( TT ) , fibrinogen , D dimers , TAT , factor 7 , activity of antithrombin 3 , activity of protein C and protein S , PAI 1 and t PA concentration . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
In addition , several plasma parameters , like PAI 1 , t PA , D dimers , prothrombin fragment F 1 + 2 , fibrinogen , ATIII activity , troponin 1 and CK MB , as well as platelet count were determined at each time point . ^^^ In these patients , fibrinolysis parameters tended to be depressed ( with increased PAI 1 dominating over elevated t PA ) on the first day after the operation , and no significant differences with regard to fibrinogen , prothrombin fragment F 1 + 2 , troponin 1 and platelet count . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
We studied thrombin antithrombin complexes ( TAT ) , prothrombin fragments 1+2 ( F1+2 ) , tissue type plasminogen activator ( tPA ) and plasminogen activator inhibitor type 1 ( PAI 1 ) concentrations in patients with acute middle cerebral artery ischemic stroke due to atherosclerotic large artery disease ( n=50 ) , lone AF ( n=24 ) and cardioembolism ( n=21 ) . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
A control group of 200 healthy subjects was also investigated for the presence of factor 5 Leiden ( FVL ) , the 20210A allele of the prothrombin ( PT 20210A ) gene , the thermolabile variant ( 677TT ) of methylenetetrahydrofolate reductase ( MTHFR ) , and the 4G / 4G genotype of the plasminogen activator inhibitor ( PAI 1 ) promoter . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Plasma plasminogen activator inhibitor type 1 ( PAI 1 ) , D dimer and prothrombin fragment F 1 + 2 were also measured . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Plasma levels of plasminogen activator inhibitor type 1 ( PAI 1 ) , tissue type plasminogen activator ( t PA ) , fibrinogen , thrombin antithrombin ( TAT ) complexes , and prothrombin fragments ( F1 . 2 ) were measured at baseline and after standardized venous occlusion ( VO ) in patients with PPH ( 24 female , 9 male ) . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Blood samples were analysed for hemoglobin ( HB ) , total platelet count ( TPC ) , C reactive protein ( CRP ) , activated partial thromboplastin time ( APTT ) , prothrombin complex ( PT ) , fibrinogen , interleukin 1 beta ( IL 1 beta ) , tumor necrosis factor alpha ( TNF alpha ) , D dimer , tissue plasminogen activator ( t PA ) , plasminogen activator inhibitor 1 ( PAI 1 ) , prothrombin fragments 1 and 2 ( F 1 + 2 ) , and thrombin antithrombin 3 complex ( TAT ) . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Activity correlated poorly with total prothrombin ( median 27 microg / g ) and was inversely related to antithrombin , but not to PAI 1 . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
The presence of SCIs was associated with older age , higher levels of 24 h systolic blood pressure , 2 h insulin , thrombin generation markers ( prothrombin fragment 1+2 and thrombin antithrombin complexes ) , plasminogen activator inhibitor 1 ( PAI 1 ) , D dimer and von Willebrand factor ( vWF ) , but not with plasmin alpha 2 plasmin complex ( PIC ) levels . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Methods and Results We performed a literature search to identify published case control studies correlating the factor 5 Leiden or prothrombin G20210A mutations or fibrinogen G 455A or plasminogen activator inhibitor 1 ( PAI 1 ) 4G / 5G polymorphisms with the risk of myocardial infarction . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
RESULTS : The children in whom the hemolytic uremic syndrome subsequently developed had significantly higher median plasma concentrations of prothrombin fragment 1+2 , tissue plasminogen activator ( t PA ) antigen , t PA plasminogen activator inhibitor type 1 ( PAI 1 ) complex , and D dimer than children with uncomplicated infection . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Prothrombin time ( PT ) , partial thromboplastin time ( PTT ) , fibrinogen ( FBG ) , platelets ( PLT ) , thrombin antithrombin complexes ( TAT ) , t PA Ag , t PA activity , plasminogen activator inhibitor 1 ( PAI 1 ) , and alpha 2 antiplasmin ( AP ) activities were measured . ^^^ Prothrombin time ( PT ) , partial thromboplastin time ( PTT ) , fibrinogen ( FBG ) , platelets ( PLT ) , thrombin antithrombin complexes ( TAT ) , t PA Ag , t PA activity , plasminogen activator inhibitor 1 ( PAI 1 ) , and alpha 2 antiplasmin ( AP ) activities were measured . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Levels or presence of protein C , protein S , antithrombin , methylenetetrahydrofolate reductase C677T , factor 5 Leiden , prothrombin gene G20210A , antiphospholipid antibodies , plasminogen , tissue type plasminogen activator ( tPA ) , type 1 tPA inhibitor ( PAI 1 ) , PAI 1 4G / 5G polymorphism , prothrombin fragment 1+2 , plasmin / alpha ( 2 ) antiplasmin complexes , thrombomodulin , and activated factors 7 and 12 were determined . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
METHODS : Subjects with an ultrasound confirmed deep venous thrombosis had prothrombin fragment 1+2 ( F 1+2 ) , tissue plasminogen activator ( t PA ) activity , plasminogen activator inhibitor ( PAI 1 ) activity , and t PA antigen levels determined before anticoagulation therapy . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
We determined , at hospital discharge , these biohemorheological parameters : plasma viscosity , fibrinogen , PAI 1 inhibitor , leukocyte count , C protein ( C Pt ) , erythrocyte aggregation ( EA ) . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Prothrombin time ( PT ) , activated partial thromboplastin time ( aPTT ) , fibrinogen , factors 5 , 7 , 8 , 9 and 10 activities , vWF , antithrombin 3 ( AT 3 ) , protein C , protein S , tissue plasminogen activator ( t PA ) and tissue plasminogen activator inhibitor 1 ( PAI 1 ) , as well as common lipid variables , were measured . ^^^ Prothrombin time ( PT ) , activated partial thromboplastin time ( aPTT ) , fibrinogen , factors 5 , 7 , 8 , 9 and 10 activities , vWF , antithrombin 3 ( AT 3 ) , protein C , protein S , tissue plasminogen activator ( t PA ) and tissue plasminogen activator inhibitor 1 ( PAI 1 ) , as well as common lipid variables , were measured . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Fasting blood samples were collected before and after 12 month treatment for determinations of fibrinogen , prothrombin fragment 1+2 ( F1+2 ) , plasma D dimer , soluble tissue factor , tissue plasminogen activator ( tPA ) antigen , tPA activity , plasminogen activator inhibitor type 1 activity ( PAI 1 activity ) and serum D dimer as a global test of fibrinolytic activity . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
The plasmatic levels of the following haemostatic factors were measured within the first 6 h of the SIRS evolution : von Willebrand Factor ( vWF ) , thrombomodulin , plasminogen activity inhibitor type 1 ( PAI 1 antigen ) , tissue type plasminogen activator ( t PA antigen ) , prothrombin fragment 1 + 2 ( F 1 + 2 ) , thrombin antithrombin complexes ( TAT ) and D dimer . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
In 78 non diabetic , normotensive first degree relatives of type 2 diabetic patients ( 47 without a family history of hypertension and 31 with a family history of hypertension ) and in 36 normoglycemic , normotensive subjects with no family history of hypertension , we evaluated plasma levels of fasting glucose and insulin , tissue type plasminogen activator ( t PA ) , plasminogen activator inhibitor ( PAI 1 ) , D dimer ( DD ) and prothrombin fragment 1 + 2 ( F1+2 ) . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
However , in contrast to healthy postmenopausal women , we recently reported that HRT did not significantly decrease PAI 1 antigen levels and rather , increased tissue factor activity and prothrombin fragment F ( 1+2 ) levels from baseline in hypertensive and / or overweight postmenopausal women . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
At the beginning and after 3 weeks of therapy , we performed a clinical and instrumental assessment ; we studied endothelial function by determination of L arginine and L citrulline ( amino acids of the nitric oxide metabolic pathway ) , the L citrulline / L arginine ratio ( an index of NOS activity ) and VCAM 1 ( endothelial dysfunction index ) ; haemorheological parameters ( blood viscosity , plasma fibrinogen and erythrocyte morphology ) ; coagulative / fibrinolytic parameters ( PT , aPTT , fibrinogen and PAI 1 ) . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
METHODS : We enrolled 49 unrelated Caucasian women with a history of two consecutive or three to six nonconsecutive early pregnancy losses and 48 unrelated parous healthy controls without a history of pregnancy loss and evaluated them for the following genetic variants : the factor 5 Leiden and prothrombin G20210A gene mutations , the methylenetetrahydrofolate reductase C677T and A1298C polymorphisms , and the PAI 1 4G / 5G and FXIII Val34Leu polymorphisms . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Blood factors were D dimer , prothrombin 1 . 2 , tissue plasminogen activator ( t PA ) antigen , plasminogen activator inhibitor 1 ( PAI 1 ) , and inflammatory markers ( high sensitivity C reactive protein [ CRP ] , fibrinogen , and serum amyloid A [ SAA ] ) . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
In conclusion , the hypofibrinolytic genotypes 4G / 4G and A / A at positions 675 and 844 of the PAI 1 gene are associated with the occurrence of mild preeclampsia independently of thrombophilic mutations of the factor 5 , prothrombin , and MTHFR genes . . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
METHODS : Fibrinolysis was assessed by measurement of tissue plasminogen activator ( t PA ) and tissue plasminogen activator inhibitor ( PAI 1 ) concentrations , whereas activation of thrombinogenesis was detected by F 1 + 2 prothrombin fragment concentration . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Coagulation parameters studied concerned prothrombin time ( PT ) , platelet count , the procoagulant system ( factors ( F ) 2 , FV , FVII , FVIII and fibrinogen ) , anticoagulant system ( AT 3 ) , fibrinolytic system ( t PA , PAI 1 ) as well as markers of coagulation factor activation ( TAT complexes , prothrombin fragment F 1 + 2 ) . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
The polymorphisms include mutations in coagulation factor genes ( Factor 5 , Prothrombin , Fibrinogen , Factor 7 , Factor 13 , PAI 1 ) , platelet activation / function ( GpIIb / IIIa , GpIb 9 5 , GpIa / IIa ) , vascular reactivity ( ACE ) , endothelial cell function ( MTHFR , thrombomodulin , VCAM 1 , E Selectin , L Selectin , P Selectin , ICAM 1 ) , inflammation ( TNFalpha ) , lipid metabolism ( Apo A 1 , Apo E ) , and cell adhesion ( VCAM 1 , E Selectin , L Selectin , P Selectin , ICAM 1 ) . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
METHODS : We determined the plasma prothrombin time ( PT ) , activated partial thromplastin time ( APTT ) , activity of tissue type plasminogen activator ( t PA ) , activity of plasminogen activator inhibitor 1 ( PAI 1 ) and fibrinogen ( Fg ) level of 24 endogenous hyper triglyceridemic patients and 34 healthy controls , and observed their relationship to serum lipids and apolipoproteins . ^^^ RESULTS : The PT and APTT of patients with hypertriglyceridemia were obviously shorter than those of control subjects ( P < 0 . 01 , P < 0 . 05 ) ; PAI 1 of patients was significant higher than that of control group ( P < 0 . 01 ) ; there was no statistically significant difference in t PAI 1 : a between the control subjects and the hypertriglyceridemic patients ; the levels of Fg in patients was 27 % higher than that in healthy control ( P < 0 . 01 ) . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
DESIGN AND METHODS : A group of 59 women with gestational hypertension were prospectively tested between 24 and 26 weeks of gestation for : ( 1 ) DNA analysis to search for gene mutations of Factor 5 Leiden , prothrombin , methylenetetrahydrofolate reductase and plasminogen activator inhibitor type 1 ( PAI 1 ) polymorphism ; ( 2 ) maternal serum concentrations of homocysteine and PAI 1 , activated protein resistance and Factor 2 : C activity levels ; ( 3 ) mean uterine arterial resistance index ( RI ) by Doppler velocimetry ; and ( 4 ) history of hypertensive disorders in relatives ( the mother and / or the father ) . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Impaired insulin sensitivity patients had significantly higher levels of C reactive protein ( CRP ) , TGF beta 1 , plasminogen activator inhibitor 1 ( PAI 1 ) , activated factor 7 ( VIIa ) , and prothrombin fragment 1 + 2 ( F 1 + 2 ) compared with either control subjects or NIS patients . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
MATERIALS AND METHODS : In a prospective study , prothrombin fragment 1 and 2 ( F1 . 2 ) , thrombin antithrombin complex ( TAT ) , antithrombin , D dimer , plasmin alpha ( 2 ) antiplasmin complex ( PAP ) and plasminogen activator inhibitor 1 ( PAI 1 ) were measured in 20 patients with Crohn ' s disease ( CD ) , 18 with ulcerative colitis ( UC ) , and 19 with giant cell arteritis during active and inactive disease , as well as in 51 controls without inflammation . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
In the patients and in 25 control subjects , plasma levels of tissue type plasminogen activator , plasminogen activator inhibitor ( PAI 1 ) , D dimer , prothrombin fragment 1 + 2 ( F 1 + 2 ) , total cholesterol , triglycerides and fibrinogen had been measured . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Allele 4G of gene PAI 1 associated with prothrombin mutation G20210A increases the risk for venous thrombosis . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Plasma levels of the thrombin activation system ( thrombin antithrombin complex [ TAT ] , tissue factor pathway inhibitor [ TFPI ] , and prothrombin fragments 1+2 [ F1+2 ] ) and plasmin activation system ( tissue and urokinase type plasminogen activator [ t PA and u PA ] , plasminogen activator inhibitor 1 [ PAI 1 ] , and D dimer ) were measured with enzyme linked immunosorbent assay kits before angiography . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
We obtained blood samples from all subjects and analyzed their DNA for 12 common polymorphisms of thrombophilic and vascular genes ( factor 5 Leiden , factor 5 H1299R , prothrombin G20210A , factor 13 V34L , MTHFR C677T , MTHFR A1298C , beta fibrinogen 455 G to A , PAI 1 4G / 5G , GPIIIa L33P , HFE C282Y , apolipoprotein B R3500Q , and apolipoprotein E2 / E3 / E4 ) . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
OBJECTIVES : To measure the plasma levels of urokinase plasminogen activator ( uPA ) , urokinase plasminogen activator receptor ( uPAR ) and plasminogen activator inhibitor 1 ( PAI 1 ) , and study the relationship between the plasma levels of uPA , PAI 1 and the serum albumin ( Alb ) , collagen type 4 ( CIV ) , the serum hyaluronic acid ( HA ) , prothrombin time ( PT ) and prothrombin activity ( PTA ) in patients with different stages of liver cirrhosis following chronic hepatitis B . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
METHODS : Serial bronchoalveolar lavage fluid ( BALF ) samples were assayed for prothrombin activation fragment ( F1+2 ) , thrombin antithrombin ( TAT ) complex , fibrinolytic activity , urokinase type plasminogen activator ( u PA ) , and plasminogen activator inhibitor type 1 ( PAI 1 ) on days 1 , 4 , and 7 after VAP onset . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Risk factors assessed were antithrombin , protein C and S deficiency , presence of factor 5 Leiden , prothrombin G20210A , hyperhomocisteinemia , increased PAI 1 , increased factor 8 , and presence of antiphospholipid antibodies ( APAs ) . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Plasma levels of fibrinopeptide A ( FPA ) , fibrin d dimer , thrombin antithrombin ( TAT ) complex , prothrombin fragment 1 . 2 ( F1 . 2 ) , urokinase type plasminogen activator ( uPA ) , tissue type plasminogen activator ( t PA ) and plasminogen activator inhibitor 1 ( PAI 1 ) were measured before and after therapy , as was the cellular expression of the genes for tissue factor ( TF ) and interleukin 1 beta ( IL 1 beta ) . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Polymorphisms in the thrombophilia genes [ plasminogen activator inhibitor type 1 [ PAI 1 675 ( 4G / 5G ) ] , thrombin activatable fibrinolysis inhibitor ( TAFI 438G / A and 1040C / T ) , methylenetetrahydrofolate reductase ( MTHFR 677C / T ) , factor 5 ( FV Leiden R / Q506 ) , prothrombin ( FII 20210G / A ) and factor XIIIA ( FXIIIA V / L34 ) ] were determined in 157 women with preeclampsia and 157 women with uncomplicated pregnancy . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
METHODS : In a prospective , longitudinal , case control study , we studied plasma plasminogen activator inhibitor type 1 ( PAI 1 ) activity , tissue type plasminogen activator antigen ( t PA : Ag ) , d dimer , prothrombin fragment 1+2 ( F 1+2 ) , and thrombin antithrombin 3 complex ( TAT ) levels in 55 consecutive patients on admission , 1 week , 1 month , and 3 months after an ischemic stroke . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Prothrombin fragment 1 + 2 , fibrinogen , factor 8 , antithrombin , tissue plasminogen activator antigen ( tPA ) , plasminogen activator inhibitor 1 ( PAI 1 ) , PAI 1 / tPA , and C reactive protein were significantly ( P < 0 . 05 ) higher in the hyper than in the hypothyroid state , whereas protein C and plasmin antiplasmin complexes were significantly lower during the hyperthyroid period . ^^^ When the 10 female patients were hyperthyroid , their levels of prothrombin fragment 1 + 2 , fibrinogen , protein S , antithrombin , tPA , PAI 1 , and PAI 1 / tPA were significantly higher ( P < / = 0 . 05 ) than in healthy female controls , whereas when the female patients were hypothyroid , their antithrombin and plasmin antiplasmin were lower and their protein S was higher than in controls . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Bleeding time , platelet count , prothrombin time , activated partial thromboplastin time , tissue plasminogen activator ( tPA ) , plasminogen activator inhibitor ( PAI 1 ) , euglobulin clot lysis time , protein C , protein S , fibrinogen , D dimer , factor 5 , 7 , 8 , 9 , 10 and von Willebrand factor ( VWF ) values were studied at the beginning , at 2 and 4 h of dialysis with and without administration of DDAVP at a dose level of 2 microg / kg intranasally . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
All patients underwent a screening prothrombin time , activated partial thromboplastin time , fibrinogen ( Fg ) , coagulation factors of the intrinsic and extrinsic pathways , antithrombin 3 ( AT 3 ) , protein C ( PC ) , protein S ( PS ) , resistance to activated protein C , prothrombin activation fragment 1+2 ( F1+2 ) , plasminogen , tissue type plasminogen activator ( t PA ) , plasminogen tissue activator inhibitor type 1 ( PAI 1 ) , anticardiolipin antibodies type M and G ( ACA IgM and ACA IgG ) , lupus anticoagulant antibodies , and antiprothrombin antibodies type M and G ( aPT IgM and aPT IgG ) . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Levels of antithrombin 3 , fibrinogen and plasminogen activator inhibitor 1 ( PAI 1 ) increased , whereas a reduction was observed in proteins C and S and in prothrombin time ( PT ) . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
We measured the ankle brachial index ( ABI ) and levels of D dimer , C reactive protein ( CRP ) , fibrinogen , serum amyloid A ( SAA ) , prothrombin 1 . 2 , t PA antigen , PAI 1 , and the t PA antigen / PAI 1 ratio . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Samples were analyzed for the following : factor 5 Leiden ( FVL ) , prothrombin 20210A ( P20210A ) , methylenetetrahydrofolate reductase C 677 T ( MTHFR ) , Factor 8 ( FVIII ) , Protein C ( PC ) , Lipoprotein ( a ) ( Lp ( a ) ) and plasminogen activator inhibitor 1 ( PAI 1 ) . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Fibrinolytic variables tissue plasminogen activator ( tPA ) , plasminogen activator inhibitor 1 ( PAI 1 ) activity , and antigen and prothrombin fragment 1 + 2 , a molecular marker of in vivo thrombin generation , were measured before and after maximal exercise . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
RESULTS : The plasma levels of fibrinogen , antithrombin 3 ( AT 3 ) , plasminogen activator inhibitor 1 ( PAI 1 ) , von Willebrand factor ( vWF ) activity and prothrombin time were found to be significantly increased in the type 2 diabetic patients compared with the healthy subjects . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Cox ' s univariate analysis showed that pT ( p = 0 . 0007 ) , uPA ( p = 0 . 0156 ) and PAI 1 ( p = 0 . 0015 ) had a significant impact on relapse free survival , whereas VEGF did not have any prognostic value ( p = 0 . 18 ) . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
The patients ' genotype was estimated by the thrombophylic genes : factor 5 Leiden ( FVL ) , prothrombin G20210A , methylene tetrahydrofolate reductase C677T , G / A 455FGB , 4G / 5G PAI 1 , PI A1 / A2 GPIIIa . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Other genetic variants ( prothrombin 20210A , methylenetetrahydrofolate reductase C677T , factor 13 Val34Leu , PAI 1 4G / 5G , and factor 5 HR 2 ) did not modify the association of hormone therapy with venous thrombosis . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
The 6 children with VOD ( 9 . 84 % ) had an early and significant increase in PAI 1 antigen and activity ( p < 0 . 0001 ) , t PA antigen ( p < 0 . 0001 ) and D dimer ( p < 0 . 01 ) levels , and a decrease in plasminogen , alpha 2 antiplasmin and PT emerged 2 ( + / 1 ) days before the clinical diagnosis of VOD by comparison with mean post HSCT values in the non VOD patients . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
The G20210A prothrombin gene mutation and the plasminogen activator inhibitor ( PAI 1 ) 5G / 5G genotype are associated with early onset of severe preeclampsia . ^^^ However , the onset of severe preeclampsia was significantly earlier in women with the G20210A prothrombin gene mutation ( 24 . 5 weeks vs . 30 . 1 weeks , P = 0 . 046 ) and in women with the PAI 1 5G / 5G genotype ( 25 . 7 weeks vs . 30 . 8 weeks , P = 0 . 024 ) . ^^^ However , women who are carriers of the G20210A prothrombin gene mutation and the PAI 1 5G / 5G genotype are at risk for early onset of severe preeclampsia . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Blood samples were analyzed for procoagulant factors ( prothrombin , factors 7 [ fVII ] , 8 [ fVIII ] , 9 [ fIX ] and 11 [ fXI ] , D dimer and von Willebrand factor [ vWf ] ) , anticoagulant factors ( antithrombin [ AT ] , total and free protein S , protein C and activated protein C [ APC ] resistance ) and fibrinolytic factors ( thrombin activatable fibrinolysis inhibitor [ TAFI ] and plasminogen activator inhibitor 1 [ PAI 1 ] ) , at baseline and at 6 months of treatment . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Plasma PAI 1 activity was reduced in all drug treated groups ( percentage of reduction in activity p < 0 . 05 ; 10 mg / kg PAI 039 ) , whereas ADP , 9 , 11 dideoxy 11alpha , 9alpha epoxymethanoprostaglandin F ( 2alpha ) ( U 46619 ) , and collagen induced platelet aggregation , as well as template bleeding and prothrombin time , remained unaffected by PAI 039 . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
DESIGN : In the present cross sectional study , eight SNPs of six genes involved in vascular function and homeostasis were analyzed by sequencing on chip using solid phase polymerase chain reaction on oligonucleotide microarrays in 728 white women : factor 5 ( F 5 ) Leiden G1691A , factor 2 ( F 2 ) prothrombin G20210A , plasminogen activator inhibitor 1 ( PAI 1 ) 4G / 5G , angiotensinogen ( AGT ) Met235Thr , endothelial nitric oxide synthase ( NOS 3 ) T768C and NOS 3 Glu298Asp , apolipoprotein E 1 ( APOE 1 ) Cys112Arg , and APOE 2 Arg158Cys . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
OBJECTIVE : To evaluate the role of factor 5 Leiden , prothrombin G20210A polymorphism , plasminogen activator inhibitor type 1 ( PAI 1 ) 4G / 5G polymorphism , PAI 1 , homocysteine , and lipoprotein ( a ) ( Lp ( a ) ) in the occurrence of major adverse cardiac events ( MACE ) in patients with acute coronary syndromes who underwent coronary stenting . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
The present study analyzed the effect of increasing the atorvastatin dose to 80 mg / day on indices of inflammation ( C reactive protein or CRP ) , thrombogenesis ( prothrombin fragment [ F1+2 ] ) and fibrinolysis ( tissue type plasminogen activator antigen , t PA , and its inhibitor PAI 1 ) in high risk patients with ischemic heart disease . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Blood samples were collected before surgery for determination of prothrombin fragments F 1 and 2 , thrombin antithrombin complex , tissue type plasminogen activator ( tPA ) activity and antigen , plasminogen activator inhibitor 1 ( PAI 1 ) activity and antigen , D dimer , homocysteine , fibrinogen , in plasma , and hematocrit in blood , and the patients underwent transcranial Doppler ultrasonology for evaluation of microembolic signals ( MES ) . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
We have measured : anti protein C antibodies , anti protein S antibodies , anticardiolipin antibodies ( ACA ) , anti beta 2 glycoprotein antibodies ( beta 2 GPI ) , and anti prothrombin antibodies ( aPT ) , along with prothrombin time , fibrinogen , plasminogen , protein C , protein S , anti thrombin 3 , APC resistance test , D dimer , tissue type plasminogen ' s activator , plasminogen activator inhibitor 1 ( PAI 1 ) , prothrombin fragment 1+2 , factors of the intrinsic and extrinsic pathway , C reactive protein , and homocysteine . ^^^ Significant differences between TC and NTC groups were found for anti protein C and anti protein S antibodies , ACA IgM , PAI 1 , Factor 8 , prothrombin fragments 1+2 , and homocysteine . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
We used polymerase chain reaction techniques to characterize thrombophilic gene mutations ( G1691A 5 Leiden [ FV ] , G20210A prothrombin , C677T / A1298C MTHFR ) and hypofibrinolytic gene mutations ( plasminogen activator inhibitor [ PAI 1 ] activity 4G4G ) . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
No difference between the groups was observed in plasma thrombus precursor protein , prothrombin fragment 1+2 , D dimer , t PA , PAI 1 , TM and thrombin activatable fibrinolysis inhibitor . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Levels of prothrombin fragment 1+2 ( F1+2 ) , factor 7 , plasminogen activator inhibitor 1 ( PAI 1 ) and tissue factor pathway inhibitor ( TFPI ) antigens , but not tissue plasminogen activator ( tPA ) antigen , in the pre simvastatin plasmas of the diabetic patients were significantly higher than the levels found in plasmas of healthy subjects . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
The following measurements were taken : prothrombin index , prothrombin time , thrombin time , fibrinogen , factor 7 , ATIII , D dimers , INR , APTT , protein C and PAI 1 activity , t PA activity , PAI 1 antigen , t PA antigen , glucose level , insulin level , E 2 and total fat . ^^^ RESULTS : In the AN group the INR , prothrombin time , PAI 1 activity , t PA activity , protein C level were increased , whereas PAI 1 antigen , t PA antigen , prothrombin index , fasting insulin level and fasting glucose level were decreased . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Polymerase chain reaction assays were done for four thrombophilic and one hypofibrinolytic gene mutations : G1691A factor 5 Leiden , G20210A prothrombin , C677T MTHFR , platelet glycoprotein IIb / IIIa ( PL A1 / A2 ) , and 4G / 5G polymorphism of the plasminogen activator inhibitor ( PAI 1 ) gene promoter . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
The following parameters were determined : prothrombin time ( PT ) , activated partial thromboplastin time ( aPTT ) , factors 7 , 10 , and 12 activity , fibrinogen levels , thrombin antithrombin complex levels , protein C and S antigen , antithrombin activity , plasminogen activator inhibitor type 1 ( PAI 1 ) antigen , tissue type plasminogen activator ( t PA ) antigen , plasminogen activity and fibrin degradation products ( FbDP ) antigen . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Blood was taken prior to PCI for baseline measurement of : ( 1 ) vasoconstrictive factors : endothelin ( ET ) and serotonin ( 5 HT ) ; ( 2 ) thrombotic factors : tissue factor ( TF ) , plasminogen activator inhibitor ( PAI 1 ) , thrombin / antithrombin 3 complex ( TAT ) , and prothrombin fragment F1+2 ( F1+2 ) ; and ( 3 ) inflammatory factors : soluble CD 40 ligand ( sCD40L ) and soluble E selectin . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
In 438 patients with AAA , and in 438 healthy subjects , selected to be comparable for age and gender with patients and without instrumental evidence of AAA , a pattern of thrombophilic parameters [ homocysteine ( Hcy ) , lipoprotein ( a ) [ Lp ( a ) ] , plasminogen activator inhibitor 1 ( PAI 1 ) , anticardiolipin antibodies ( ACA ) , MTHFR C677T polymorphism , prothrombin gene G20210A variant and FactorV Leiden mutation ] has been evaluated . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
METHODS : In 586 consecutive patients , referred because of bleeding symptoms , we added analyses of PAI 1 activity and tissue plasminogen activator complex with PAI 1 ( t PA PAI 1 ) to the routine investigation , consisting of platelet count , bleeding time , prothrombin time , activated partial thromboplastin time , fibrinogen , factor 8 , von Willebrand factor activity , and antigen . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
As gene variants predisposing to thrombophilia and influencing the increased risk of vein thrombosis might influence response to local thrombolysis , the aim of the work was to characterize the pharmacogenetic conditions for local streptokinase treatment in patients with a deep vein thrombosis ( DVT ) of lower extremities based on the following polymorphism analyses : G1691A polymorphism of factor 5 ( FV ) , G20210A polymorphism of prothrombin ( PT ) , A4250G ( Thr312Ala ) polymorphism of fibrinogen alpha ( FGA ) , G ( 455 ) A polymorphism of fibrinogen beta ( FGB ) , 4G / 5G polymorphism of plasminogen activator inhibitor type 1 ( PAI 1 ) and insertion / deletion ( I / D ) polymorphism of tissue plasminogen activator ( t PA ) . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Prothrombin time ( PT ) , activated partial thromboplastin time ( aPTT ) , fibrinogen , factors 5 , 7 , 8 , 9 and 10 activities , vWF , antithrombin 3 ( AT 3 ) , protein C , protein S , tissue plasminogen activator ( t PA ) and tissue plasminogen activator inhibitor 1 ( PAI 1 ) , as well as common lipid variables , were measured . ^^^ Prothrombin time ( PT ) , activated partial thromboplastin time ( aPTT ) , fibrinogen , factors 5 , 7 , 8 , 9 and 10 activities , vWF , antithrombin 3 ( AT 3 ) , protein C , protein S , tissue plasminogen activator ( t PA ) and tissue plasminogen activator inhibitor 1 ( PAI 1 ) , as well as common lipid variables , were measured . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
In blood samples , the following markers of coagulation / fibrinolysis were measured before treatment : fibrinogen , prothrombin fragments 1+2 , Factor 13 , Factor 7 , alpha 2 antiplasmin , plasminogen activator inhibitor 1 ( PAI 1 ) , and thrombin activatable fibrinolysis inhibitor . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
METHOD OF STUDY : A total of 150 women with a history of two or more recurrent pregnancy losses and 20 fertile control women with no history of pregnancy losses had buccal swabs taken for DNA analyses of 10 gene mutations [ factor 5 G1691A , factor 5 H1299R ( R 2 ) , factor 5 Y1702C , factor 2 prothrombin G20210A , factor 13 V34L , beta fibrinogen 455G > A , PAI 1 4G / 5G , HPA 1 a / b ( L33P ) , MTHFR C677T , MTHFR A1298C ] . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
METHODS : Meta analyses were done of 191 studies in relation to factor 5 G1691A ( ie , factor 5 Leiden ) , factor 7 G10976A , prothrombin G20210A , plasminogen activator inhibitor 1 ( PAI 1 ) [ 675 ] 4G / 5G , and three platelet glycoprotein ( GP ) receptor variants ( GPIa C807T , GPIbalpha T [ 5 ] C , GPIIIa C1565T ) , involving a total of 66 155 coronary disease cases and 91 307 controls . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Activated Partial Thromboplastin Time , Prothrombin Time , Fibrinogen , Factor 7 , Antithrombin 3 , Protein C , Plasminogen , alpha 2 Plasmin Inhibitor , Plasminogen Activator Inhibitor 1 , tissue Plasminogen Activator were functionally evaluated . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
We determined prothrombin time , activated partial thromboplastin time , clotting factor 8 activity , tissue plasminogen activator activity , tissue plasminogen activator inhibitor 1 , cross linked fibrin degradation product , and thrombin antithrombin 3 complexes . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Among coagulation factors , only thrombin antithrombin ( TAT ) complexes were twice as high in embolic as in nonembolic patients ( 14 . 0 + / 13 . 6 vs . 7 . 0 + / 4 . 2 ng / ml ; p < 0 . 02 ) , while there was no statistically significant difference between embolic and nonembolic patients for activated partial thromboplastin time , prothrombin time , antithrombin 3 , protein C , fibrinogen , plasminogen , alpha 2 plasmin inhibitor , and plasminogen activator inhibitor 1 . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Plasma concentrations of prothrombin fragments F 1 + F 2 , fibrinogen , plasminogen , and plasminogen activator inhibitor 1 were unaffected . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Blood samples for platelet count , platelet response to adenosine diphosphate , plasma beta thromboglobulin , inactivated complement 3b , neutrophil elastase , fibrinopeptide A , prothrombin fragment F1 . 2 , thrombin antithrombin complex , tissue plasminogen activator , plasminogen activator inhibitor 1 , plasmin alpha 2 antiplasmin complex , and D dimer were obtained at these times : after heparin was given , 5 and 30 minutes after cardiopulmonary bypass was started , within 5 minutes after bypass was stopped , and 15 minutes after protamine was given . ^^^ There were no significant differences between groups at any time for fibrinopeptide A , prothrombin fragment F1 . 2 , or thrombin antithrombin complex or in the markers for fibrinolysis : D dimer , tissue plasminogen activator , plasminogen activator inhibitor 1 , and alpha 2 antiplasmin complex . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
The levels of prothrombin complex , fibrinogen , plasminogen activator inhibitor 1 were increased in women who had previously had severe preeclampsia as compared to those who had had mild preeclampsia ( p < 0 . 01 ) . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Levels of antiphospholipid antibodies ( anticardiolipin antibodies and lupus anticoagulant ) , plasminogen activator inhibitor 1 , fibrinogen , antithrombin 3 , protein C , protein S , plasminogen , prothrombin fragment F 1 + 2 , and D dimer were determined for these young women and for 21 age matched white female control subjects without vascular disease and nine white male patients with aortoiliac occlusive disease ( mean 61 years , range 43 to 74 years ) . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Components of the coagulation ( thrombin antithrombin complexes , prothrombin fragment F 1 + 2 , activated factor 7 , and factor 7 antigen ) and fibrinolytic ( fibrin split product D dimer , plasmin plasmin inhibitor complex , tissue type plasminogen activator , urokinase type plasminogen activator , and plasminogen activator inhibitor 1 ) systems and markers of endothelial cell perturbation / dysfunction ( von Willebrand factor and thrombomodulin ) were measured before the start of infusion and after 2 , 6 , 12 , and 24 hours . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Patients with hypodense lesions verified on follow up CT scanning or with persistent neurological deficits at 3 months had higher prothrombin fragments 1 and 2 , TAT , D dimer , and plasminogen activator inhibitor 1 values on the 1st day postoperatively than did patients without such lesions . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
MAIN OUTCOME MEASURES : Concentrations of haemoglobin , tissue type plasminogen activator and plasminogen activator inhibitor 1 ; activated partial thromboplastin time ; prothrombin time ; platelet and reticulocyte counts ; blood loss ; and transfusions . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
No differences between groups , however , could be observed with respect to partial thromboplastin time , prothrombin time , platelets , plasminogen activator inhibitor 1 , soluble tumor necrosis factor receptor 2 , neutrophil elastase , interleukin ( IL ) 1 receptor antagonist , IL 6 , and IL 8 . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Platelet count , antithrombin , fibrinogen , prothrombin fragment F1+2 , soluble thrombomodulin , tissue plasminogen activator , D dimer , and plasminogen activator inhibitor 1 antigen were investigated . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
METHODS : A series of hemostatic tests and parameters including activated partial thromboplastin time , prothrombin time , thrombin time , bleeding time , factor 8 assay , antithrombin activity , fibrinogen , plasminogen , protamine sulfate test , fibrin ( ogen ) degradation products , D dimer , thrombin antithrombin complex ( measured by modified antithrombin ) , tissue plasminogen activator ( tPA ) , plasminogen activator inhibitor 1 , euglobulin lysis test and venous occlusion test were performed in 51 patients with cirrhosis of the liver and 33 healthy controls . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
These treatments differ , however , in their effects on high density lipoprotein cholesterol , triglycerides , and plasminogen activator inhibitor 1 and possibly in their effects on prothrombin fragment F1+2 and C reactive protein . . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Fibrinogen correlated positively with white blood cells ( WBC ) ( r = 0 . 25 ) , prothrombin fragment 1 . 2 ( F1 . 2 ) ( r = 0 . 21 ) , cholesterol ( r = 0 . 27 ) , beta thromboglobulin ( r = 0 . 29 ) , Factor 7 clotting activity ( FVIIc ) ( r = 0 . 27 ) ( all P < 0 . 0001 ) , tissue plasminogen activator antigen ( t PAag ) ( r = 0 . 22 , P < 0 . 0005 ) , plasminogen activator inhibitor 1 antigen ( PAI 1ag ) ( r= 0 . 20 ) and VCAM 1 ( r= 0 . 19 ) ( both P < 0 . 002 ) . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Serial measurements of coagulation variables ( prothrombin time , activated partial thromboplastin time , FVII activity , fibrinogen , tissue factor activity ) , anticoagulant proteins ( protein C , antithrombin ) and fibrinolytic factors ( tissue plasminogen activator , plasminogen activator inhibitor 1 ) were performed for 5 h . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
With change from baseline the main outcome measure , HRT increased the markers of coagulation ( prothrombin fragments 1+2 , 0 . 20+ / 0 . 06 versus 0 . 06+ / 0 . 04 nmol / L , P=0 . 0005 ; soluble fibrin , 2 . 3+ / 0 . 4 versus 0 . 25+ / 0 . 3 microgram / mL , P=0 . 0004 ) , reduced plasma fibrinolytic inhibitory activity ( plasminogen activator inhibitor 1 , 0 . 67+ / 0 . 16 versus 0 . 24+ / 0 . 21 U / mL , P=0 . 002 ) , and increased fibrinolysis ( D dimer , 24+ / 12 versus 6+ / 8 ng / mL , P=0 . 04 ) compared with placebo . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Coagulation tests included determinations of the prothrombin time , the activated partial thromboplastin time , the thrombin time , the thrombin antithrombin complex , the prothrombin fragment F 1 + 2 , the tissue plasminogen activator , the plasminogen activator inhibitor 1 , protein C activity and free protein S antigen . ^^^ Elevated concentrations of the prothrombin fragment F 1 + 2 , the thrombin antithrombin complex , D Dimer , tissue plasminogen activator and plasminogen activator inhibitor 1 were detected in most of the children . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
In total , 22 functional and immunologic assays were applied to plasma obtained from domestic pigs , and the following blood coagulation and fibrinolysis variables were measured : prothrombin time , activated partial thromboplastin time , tissue factor , tissue factor pathway inhibitor , factor 7 , protein C , protein S , prothrombin fragment 1+2 , antithrombin , thrombin antithrombin complexes , fibrinogen , soluble fibrin , urokinase type plasminogen activator , plasmin inhibitor , plasminogen activator inhibitor 1 , and D dimer . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
The polymorphisms studied were : G1691A in Factor 5 ( Factor 5 Leiden ; FVL ) , prothrombin G20210A , methylenetetrahydrofolate reductase ( MTHFR ) C677T , plasminogen activator inhibitor 1 4G / 5G and the platelet collagen receptor alpha2beta1 C807T . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
The clinical course of the patients was recorded and inflammatory and fibrinolytic markers ( C reactive protein , fibrinogen , interleukin 6 , plasminogen activator inhibitor 1 , prothrombin time , activated partial thromboplastin time , platelets and white blood cell counts ) were determined before surgery , 24 , 48 and 72 hours thereafter , and at hospital discharge . ^^^ Plasminogen activator inhibitor 1 , prothrombin time , and activated partial thromboplastin time increased from few hours postoperatively and returned to normal before discharge . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
MATERIAL AND METHODS : Among 113 primary isolated coronary artery bypass patients , CRP was determined preoperatively and fibrinogen , interleukine 6 , plasminogen activator inhibitor 1 , prothrombin time , activated partial thromboplastin time , platelets and white blood cells count measured before surgery , 24 , 48 and 72h thereafter and at hospital discharge . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Molecular genetic testing was performed for factor 5 Leiden , prothrombin promoter G20210A , methylenetetrahydrofolate reductase C677T , plasminogen activator inhibitor 1 4G / 4G , and platelet glycoprotein IIb / IIIa A1 / A2 or A2 / A2 mutations . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
The mutations / polymorphisms studied included Factor 5 Leiden , prothrombin variant G20210A , beta fibrinogen 448 ( G / A ) , endothelial protein C receptor ( 23 base pair insertion ) , methyl tetrahydrofolate reductase 677 ( C / T ) , platelet glycoprotein IIIa PlA1 / A2 , plasminogen activator inhibitor 1 4G / 5G , angiotensin 2 type 1 receptor ( A / C ) , hemochromatosis gene 282 ( G / A ) , nitric oxide synthase ( NOS ) ( 3 forms : eNOS , eNOS 3 , eNOS 4 ) , p 22 phox of NADPH oxidase C242T , and angiotensin converting enzyme insertion / deletion polymorphism . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
The present study was designed to analyse the role of the factor 5 Leiden and the prothrombin G20210A mutations and plasminogen activator inhibitor 1 4G / 5G polymorphism on the thrombotic risk of patients with Behcet ' s disease . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
The aim of this study was to investigate systemic coagulation activity , fibrinolytic capacity , and platelet activation in IE patients with and without embolic events by measuring the plasma levels of prothrombin fragment 1 + 2 , thrombin antithrombin 3 complex , plasminogen activator inhibitor 1 , beta thromboglobulin , and platelet factor 4 . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Similarly , in both groups the plasma levels of fibrinogen , thrombin antithrombin 3 complexes , prothrombin fragments F 1 + 2 , plasminogen activator inhibitor 1 , soluble E selectin , soluble P selectin and von Willebrand factor significantly increased after the procedure ( all p < 0 . 05 vs baseline values ) , without any difference between groups ( all p = NS ) . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
The clinical course of the patients was prospectively recorded , and several inflammatory and fibrinolytic markers ( C reactive protein , fibrinogen , interleukin 6 , plasminogen activator inhibitor 1 , prothrombin time , activated partial thromboplastin time , platelets , and white blood cell counts ) were determined before surgical intervention ; 24 , 48 , and 72 hours thereafter ; and at hospital discharge . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Common variations in the genes encoding factor 5 , prothrombin , angiotensin 1 converting enzyme , 5 , 10 methylenetetrahydrofolate reductase , endothelial cell nitric oxide synthase , tissue plasminogen activator , plasminogen activator inhibitor 1 , and fibrinogen were evaluated . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Antithrombin , protein C , protein S , lupus anticoagulants , homocysteine , factor 5 Leiden mutation , prothrombin 20210G > A polymorphism , methylenetetrahydrofolate reductase ( MTHFR ) 677C > T polymorphism and the 675 ( 4G / 5G ) polymorphism in plasminogen activator inhibitor 1 gene were analysed . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Specifically , we consider polymorphisms in coagulation factors ( fibrinogen , prothrombin , FV Leiden , FVII , and FXIII ) ; fibrinolytic factors ( tissue type plasminogen activator , plasminogen activator inhibitor 1 , and thrombin activatable fibrinolysis inhibitor ) ; platelet surface receptors ; methylenetetrahydrofolate reductase ; endothelial NO synthase ; and the antioxidant enzymes paraoxonase and plasma glutathione peroxidase . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Platelet count , platelet aggregation , beta thromboglobulin , prothrombin fragment F1 . 2 , thrombin antithrombin complex , plasminogen activator inhibitor 1 , alpha 2 plasmin inhibitor plasmin complex , D dimer , neutrophil elastase , and interleukin 6 were measured before , during , and after bypass . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Factor 5 gene , prothrombin gene and tissue factor gene in clotting system , thrombomodulin gene and antithrombin 3 in anticlotting system , plasminogen activator inhibitor 1 gene in fibrinolytic system , are related with hypercoagulability tightly . . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
We will discuss the functional implications and association with disease risk of polymorphisms in coagulation factors ( fibrinogen , prothrombin , and factor 5 ) ; fibrinolytic factors ( plasminogen activator inhibitor 1 and lipoprotein ( a ) ) ; platelet surface receptors ; and vascular redox determinants ( methylenetetrahydrofolate reductase , endothelial nitric oxide synthase , and the antioxidant enzymes cellular glutathione peroxidase and paraoxonase ) . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
STUDY DESIGN : Eighty nine allogeneic stem cell recipients and their donors were evaluated prospectively for the presence of the factor 5 G1691A mutation , the prothrombin G20210A mutation , the 5 , 10 methylenetetrahydrofolate reductase ( MTHFR ) C677T mutation , the glycoprotein IIIa PI ( a1 / a2 ) polymorphism , the fibrinogen beta chain 455G / A polymorphism , the plasminogen activator inhibitor 1 675 4G / 5G polymorphism , and the angiotensin converting enzyme intron 16 I / D polymorphism . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
The proband was heterozygous for the G1691A factor 5 Leiden , G20210A prothrombin , and platelet glycoprotein IIIa PL A1 / A2 mutations , had high factor 8 ( 221 % ) , and was homozygous for the 4G4G plasminogen activator inhibitor 1 gene mutation , with high plasminogen activator inhibitor activity ( 23 . 7 U / mL ) . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
No differences between groups were found in CD 61 , CD62P , and CD42b surface expression , but markers of the coagulation cascade and fibrinolysis or endothelial injury ( F1+2 prothrombin fragments , tissue plasminogen activator inhibitor 1 ) were elevated in patients treated with CyA compared with children on steroids and healthy controls . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Assays were done for factor 5 Leiden , prothrombin G20210A , methylenetetrahydrofolate reductase C677T , and plasminogen activator inhibitor 1 4G / 5G gene mutations . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
OBJECTIVE : Diurnal variations in levels of factor 7 ( FVII ) , FVIII , proteins C and S , antithrombin , plasminogen activator inhibitor 1 , prothrombin fragment F1+2 , and D dimers in healthy humans point to the existence of circadian rhythms of coagulation factors . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
The following metabolic and genetic risk factors were evaluated : lipoprotein ( a ) , homocysteine , antiphospholipid antibodies , plasminogen activator inhibitor 1 , factor 5 Leiden mutation , prothrombin variant , and 5 , 10 methylenetetrahydrofolate reductase ( MTHFR ) C677T polymorphism . ^^^ RESULTS : Multivariate logistic regression analysis , adjusted for traditional cardiovascular risk factors , showed a significant association between PAD symptoms and prothrombin variant , altered levels of homocysteine , lipoprotein ( a ) , plasminogen activator inhibitor 1 , and antiphospholipid antibodies . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Serum levels of lipids [ high density lipoprotein and low density lipoprotein cholesterol , triglycerides and lipoprotein ( a ) ] and hemostatic factors ( prothrombin , fibrinogen , plasminogen activator inhibitor 1 , and fibrin D dimer ) were also measured . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Commonly diagnosed thrombophilic states in our population currently include protein S or C deficiency , antiphospholipid antibodies , and less commonly ATIII deficiency , factor 5 Leiden mutation , G20210A PT mutation , and plasminogen activator inhibitor 1 mutation . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Blood samples were analyzed for protein C ( PC ) ; protein S ; antithrombin ( AT ) ; activated PC resistance ( APCR ) ; lipoprotein ( a ) [ Lp ( a ) ] ; lupus anticoagulant ; anticardiolipin antibodies ; and the methylenetetrahydrofolate reductase C677T ( MTHFR ) , factor 5 G1619A , factor 2 G20210A ( PT ) , plasminogen activator inhibitor 1 4G6755G , and tissue factor pathway inhibitor C536T mutations . ^^^ RESULTS : At least 1 prothrombotic abnormality was identified in 63 % ( 36 of 57 ) of children studied , including plasminogen activator inhibitor 1 4G6755G ( 15 of 56 ) , MTHFR ( 12 of 56 ) , elevated Lp ( a ) ( 12 of 59 ) , APCR ( 11 of 58 ) , factor 5 G1619A ( 5 of 57 ) , PT ( 3 of 57 ) , PC deficiency ( 1 of 59 ) , and AT deficiency ( 1 of 59 ) . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Of the four participants , participant 10 had the highest baseline values of prothrombin fragments 1 and 2 , thrombin antithrombin 3 complexes , tissue plasminogen activator , plasminogen activator inhibitor 1 , D dimer and soluble thrombomodulin . ^^^ Over time , in participant 10 , venous prothrombin fragments 1 and 2 , thrombin antithrombin 3 complexes , and soluble thrombomodulin decreased in both limbs ; D dimer decreased in the lower limbs but increased in the upper limbs ; the tissue plasminogen activator / plasminogen activator inhibitor 1 molar ratio increased in both limbs ; and minimal changes were noted in haematocrit . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
Prothrombin time ( PT ) and activated partial thrombplastin time ( APTT ) , tissue plasminogen activator and plasminogen activator inhibitor 1 , and platelet aggregation rate were determined with a reaction system consisting of mixed fresh normal plasma , in endogenous hypertriglyceridemic ( HTG ) patients , in in vitro modified lipoproteins from a normolipidemic donor , and in experimental rats . ^^^ Prothrombin time ( PT ) and activated partial thrombplastin time ( APTT ) , tissue plasminogen activator and plasminogen activator inhibitor 1 , and platelet aggregation rate were determined with a reaction system consisting of mixed fresh normal plasma , in endogenous hypertriglyceridemic ( HTG ) patients , in in vitro modified lipoproteins from a normolipidemic donor , and in experimental rats . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
The adenosine agonist n phenylisopropyladenosine ( PIA 1 mumol / l ) , acting through the Gi protein , attenuated FSH stimulated cAMP production , and this effect was abolished when the Gi protein was inactivated by preincubation with PT . ^^^
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05121 and P00734	Pubmed	SVM Score :0.0
NA