| Interacting proteins: P05093 and P16435 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05093 and P16435 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05093 and P16435 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05093 and P16435 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05093 and P16435 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05093 and P16435 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05093 and P16435 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05093 and P16435 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05093 and P16435 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05093 and P16435 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05093 and P16435 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05093 and P16435 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05093 and P16435 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05093 and P16435 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05093 and P16435 |
Pubmed |
SVM Score :0.53082938 |
| Simultaneous expression plasmids were constructed for bovine adrenal cytochromes P450c17 and P450c21 ( pA gamma alpha ) and for both P450s together with NADPH cytochrome P 450 reductase ( pAR gamma alpha ) . 0.53082938^^^ |
|
| Interacting proteins: P05093 and P16435 |
Pubmed |
SVM Score :0.0 |
| Seven P450 / reductase fused enzymes were produced in Saccharomyces cerevisiae by expressing fused cDNAs consisting of bovine cytochrome P450c17 ( P450c17 ) and yeast NADPH cytochrome P 450 reductase ( reductase ) . ^^^ |
|
| Interacting proteins: P05093 and P16435 |
Pubmed |
SVM Score :0.0 |
| In this study , the mRNAs encoding NADPH cytochrome P 450 reductase ( P 450 reductase ) , adrenodoxin , lanosterol 14 demethylase P 450 ( CYP 51 ) , 17 alpha hydroxylase P 450 ( CYP 17 ) , cholesterol side chain cleavage P 450 ( CYP11A1 ) , sterol 27 hydroxylase P 450 ( CYP 27 ) , and aromatase P 450 ( CYP 19 ) were examined in day 4 mouse blastocysts ( day 1 = vaginal plug ) and in day 13 and 16 pig blastocysts using reverse transcription polymerase chain reaction ( RT PCR ) . ^^^ |
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| Interacting proteins: P05093 and P16435 |
Pubmed |
SVM Score :0.0 |
| Using isolated membrane fractions , the truncated P450c17 also showed 17 , 20 lyase activity upon reconstitution with rat liver microsomal NADPH cytochrome P 450 reductase . ^^^ |
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| Interacting proteins: P05093 and P16435 |
Pubmed |
SVM Score :0.0 |
| The expected enzymatic activities of human P450c17 were reconstituted by addition of purified rat liver NADPH cytochrome P 450 reductase , giving turnover numbers of 8 . 0 nmol / min / nmol P 450 for pregnenolone , 6 . 5 nmol / min / nmol P 450 for progesterone , 0 . 06 nmol / min / nmol P 450 for 17 alpha hydroxypregnenolone , and no detectable activity for 17 alpha hydroxyprogesterone . ^^^ |
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| Interacting proteins: P05093 and P16435 |
Pubmed |
SVM Score :0.0 |
| The primate adrenal zona reticularis is defined by expression of cytochrome b 5 , 17alpha hydroxylase / 17 , 20 lyase cytochrome P 450 ( P450c17 ) and NADPH cytochrome P 450 reductase ( reductase ) but not 3beta hydroxysteroid dehydrogenase / delta5 4 isomerase ( 3beta HSD ) . ^^^ |
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| Interacting proteins: P05093 and P16435 |
Pubmed |
SVM Score :0.0 |
| We transfected human embryonic kidney ( HEK 293 ) cells with various amounts of vectors expressing P450c17 , NADPH cytochrome P 450 reductase , and cytochrome b 5 . ^^^ |
|
| Interacting proteins: P05093 and P16435 |
Pubmed |
SVM Score :0.0 |
| Three factors can increase the degree of 17 , 20 lyase activity relative to the 17alpha hydroxylase activity by increasing electron flow from POR : a high molar ratio of POR to P450c17 , serine phosphorylation of P450c17 , and the presence of cytochrome b ( 5 ) , acting as an allosteric factor to promote the interaction of POR with P450c17 . ^^^ |
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| Interacting proteins: P05093 and P16435 |
Pubmed |
SVM Score :0.0 |
| Truncated forms of the flavoprotein ( residues 46 676 of the mutant or 57 676 of wild type NADPH cytochrome P 450 reductase ) are unable to transfer electrons to cytochrome P450c17 or P4503A4 , confirming the importance of the N terminal sequence for catalysis . ^^^ |
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| Interacting proteins: P05093 and P16435 |
Pubmed |
SVM Score :0.0 |
| This ratio is regulated posttranslationally by at least three factors : the abundance of the electron donating protein P 450 oxidoreductase ( POR ) , the presence of cytochrome b 5 and the serine phosphorylation of P450c17 . ^^^ |
|
| Interacting proteins: P05093 and P16435 |
Pubmed |
SVM Score :0.0 |
| Assays that were based on cytochrome c , which is not a physiologic substrate for POR , correlated poorly with clinical phenotype , but assays that were based on POR ' s support of catalysis by P450c17 the enzyme most closely associated with the hormonal phenotype provided an excellent genotype / phenotype correlation . ^^^ |
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| Interacting proteins: P05093 and P16435 |
Pubmed |
SVM Score :0.0 |
| Using NADPH cytochrome P 450 reductase as electron donor the homogeneous pig 17 alpha hydroxylase 17 , 20 lyase ( CYP 17 ) was shown to catalyse the conversion of delta 5 , as well as delta 4 , steroids ( pregnenolone and progesterone respectively ) predominantly into the corresponding 17 alpha hydroxylated products . ^^^ |
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| Interacting proteins: P05093 and P16435 |
Pubmed |
SVM Score :0.0 |
| The results suggest that Antley Bixler syndrome with abnormal genitalia and / or impaired steroidogenesis is caused by POR mutations , and that clinical features are variable and primarily explained by impaired activities of POR dependent CYP51A1 , CYP17A1 , CYP21A2 , and CYP19A1 . . ^^^ |
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