| Interacting proteins: P05019 and P14735 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P05019 and P14735 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05019 and P14735 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05019 and P14735 |
Pubmed |
SVM Score :0.0 |
| Since IDE binds insulin with 600 fold greater affinity than it does insulin like growth factor 1 ( 25 nM and approximately 16 , 000 nM , respectively ) , the first set of analogues studied were hybrid molecules of insulin and IGF 1 . ^^^ IGF 1 mutants [ insB 1 17 , 17 70 ] IGF 1 , [ Tyr 55 , Gln 56 ] IGF 1 , and [ Phe 23 , Phe 24 , Tyr 25 ] IGF 1 have been synthesized and share the property of having insulin like amino acids at positions corresponding to primary sites of cleavage of insulin by IDE . ^^^ Whereas the first two exhibit affinities for IDE similar to that of wild type IGF 1 , the [ Phe 23 , Phe 24 , Tyr 25 ] IGF 1 analogue has a 32 fold greater affinity for the immobilized enzyme . ^^^ Removal of the eight amino acid D chain region of IGF 1 ( which has been predicted to interfere with binding to the 23 25 region ) results in a 25 fold increase in affinity for IDE , confirming the importance of residues 23 25 in the high affinity recognition of IDE . ^^^ |
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| Interacting proteins: P05019 and P14735 |
Pubmed |
SVM Score :0.0 |
| The effect of insulin like growth factors ( IGF 1 and IGF 2 ) on insulin degradation was studied with the use of a preparation of insulin protease from rat skeletal muscle . ^^^ Insulin protease also degraded 125I iodo IGF 1 and 125I iodo IGF 2 . 125I iodo IGF 2 was degraded more rapidly than was 125I iodo IGF 1 . 125I iodoinsulin was degraded more rapidly than 125I iodo IGF 2 . ^^^ |
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| Interacting proteins: P05019 and P14735 |
Pubmed |
SVM Score :0.0 |
| A human insulin degrading enzyme purified from IM 9 lymphocytes was tested for its ability to degrade insulin like growth factor 1 ( IGF 1 ) and insulin like growth factor 2 ( IGF 2 ) . ^^^ |
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| Interacting proteins: P05019 and P14735 |
Pubmed |
SVM Score :0.0 |
| In situ hybridization was used to investigate the cellular distribution of IDE mRNA and to compare it with insulin receptor ( IR ) and IGF 1 receptor ( IGFR ) gene expression in serial thin sections from a variety of tissues in embryonic and adult rats . ^^^ |
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| Interacting proteins: P05019 and P14735 |
Pubmed |
SVM Score :0.0 |
| To explore the potential mechanism for the IDE control of MCP activity , dose response curves for insulin like growth factor 1 ( IGF 1 ) and IGF 2 effects on MCP chymotrypsin like activity were determined . ^^^ IGF 2 , which ( similar to insulin ) is a good substrate for IDE , had a substantial inhibitory effect , whereas IGF 1 , which is bound but poorly degraded , had little inhibitory activity on MCP . ^^^ |
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| Interacting proteins: P05019 and P14735 |
Pubmed |
SVM Score :0.0 |
| Concomitant with the insulin receptors , two other growth factor receptors ( IGF 1 and IL 2 ) also emerge on the T lymphocyte cell surface along with intracellular signal transduction mechanisms and insulin degrading enzyme ( IDE ) . ^^^ |
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| Interacting proteins: P05019 and P14735 |
Pubmed |
SVM Score :0.0 |
| Insulin and IGF 1 may modulate brain levels of insulin degrading enzyme , which would also lead to an accumulation of Abeta amyloid . . ^^^ |
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