Pubmed abstracts for Protein-Protein Interaction search result :


Interacting proteins: P05019 and P07858 Pubmed SVM Score :0.0
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Interacting proteins: P05019 and P07858 Pubmed SVM Score :0.0
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Interacting proteins: P05019 and P07858 Pubmed SVM Score :0.0
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Interacting proteins: P05019 and P07858 Pubmed SVM Score :0.0
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Interacting proteins: P05019 and P07858 Pubmed SVM Score :0.0
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Interacting proteins: P05019 and P07858 Pubmed SVM Score :0.0
The potential effects of insulin like growth factor 1 ( IGF 1 ) on lysosomal cysteine proteinases ( cathepsin B , H and L+B activities ) were investigated in the freshly isolated proximal tubule cells of rats . ^^^
Interacting proteins: P05019 and P07858 Pubmed SVM Score :0.0
The IGF 1 had no effect ( P > . 05 ) on cathepsin B and D gene expression but slightly increased ( P < . 05 ) m calpain and alpha tubulin mRNA concentrations . ^^^
Interacting proteins: P05019 and P07858 Pubmed SVM Score :0.0
We have postulated that IGF 2 , the Ser 29 IGF 2 variant ( vIGF 2 ) and IGF 1 on lysosomal cathepsin B and L activities from post natal rabbit chondrocytes in vitro . ^^^
Interacting proteins: P05019 and P07858 Pubmed SVM Score :0.0
In addition , the influence of IGF 1 on cathepsin B , proteasome , and calpain activities was determined . ^^^ Additionally , IGF 1 blocked the dexamethasone induced increase in cathepsin B , proteasome , and calpain activities . ^^^
Interacting proteins: P05019 and P07858 Pubmed SVM Score :0.0
In vitro proteolysis of IGF 1 using an endosomal lysate required an acidic pH and was sensitive to CA 074 , an inhibitor of the cathepsin B enzyme . ^^^ By nondenaturing immunoprecipitation , the acidic IGF 1 degrading activity was attributed to the luminal species of endosomal cathepsin B with apparent molecular masses of 32 and 28 kDa . ^^^ The rate of IGF 1 hydrolysis using an endosomal lysate or pure cathepsin B was found to be optimal at pH 5 6 and moderate at pH 4 and 7 . ^^^ Competition studies revealed that EGF and IGF 1 share a common binding site on the cathepsin B enzyme , with native IGF 1 displaying the lowest affinity for the protease ( IC 50 approximately 1 . 5 microM ) . ^^^ Treatment of human HepG 2 hepatoma cells with the cathepsin B proinhibitor CA 074 Me reduced , in vivo , the intracellular degradation of internalized [ 125I ] IGF 1 and , in vitro , the degradation of exogenous [ 125I ] IGF 1 incubated with the cell lysates at pH 5 . ^^^