| Interacting proteins: P51654 and P01344 |
Pubmed |
SVM Score :0.0 |
| Growth promotion of HepG 2 hepatoma cells by antisense mediated knockdown of glypican 3 is independent of insulin like growth factor 2 signaling . ^^^ |
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| Interacting proteins: P51654 and P01344 |
Pubmed |
SVM Score :0.0 |
| As part of characterizing AF IGF 2 binding , we also show that the prominent high molecular mass IGF 2 binding protein in preterm AF is GPC 3 , a protein of the glypican family , recently cloned because its mutations predispose to Wilms ' tumor . ^^^ |
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| Interacting proteins: P51654 and P01344 |
Pubmed |
SVM Score :0.0 |
| In agreement with predictions , the gene is expressed in precisely the organs that overgrow in its absence ; and the patterns of expression of Gpc 3 and those reported for Igf 2 are strictly correlated . . ^^^ |
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| Interacting proteins: P51654 and P01344 |
Pubmed |
SVM Score :0.0 |
| Initial western and ligand blotting experiments suggest that glypican 3 forms a complex with insulin like growth factor 2 ( IGF 2 ) , and might thereby modulate IGF 2 action . . ^^^ |
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| Interacting proteins: P51654 and P01344 |
Pubmed |
SVM Score :0.0 |
| It has been recently suggested that glypican 3 interacts with insulin like growth factor 2 ( IGF 2 ) and that this interaction regulates IGF 2 activity . ^^^ OCI 5 / rat glypican 3 binds to fibroblast growth factor 2 but not to insulin like growth factor 2 . ^^^ |
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| Interacting proteins: P51654 and P01344 |
Pubmed |
SVM Score :0.0 |
| A phenotypically related 10 linked overgrowth syndrome , Simpson Golabi Behmel syndrome ( SGBS ) , is caused by alterations in glypican 3 ( GPC 3 ) , a molecule that may interact with the gene products identified to be important in generating the BWS phenotype , that is , IGF 2 and p57KIP2 . ^^^ |
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| Interacting proteins: P51654 and P01344 |
Pubmed |
SVM Score :0.0 |
| It encodes an extracellular proteoglycan , designated glypican 3 ( GPC 3 ) , capable of interacting with the insulin like growth factor IGF 2 . ^^^ |
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| Interacting proteins: P51654 and P01344 |
Pubmed |
SVM Score :0.0 |
| Genes such as glypican 3 ( GPC 3 ) , insulin like growth factor 2 , long chain fatty acid coenzyme A ligase 4 , farnesyl diphosphate synthase were frequently identified in our screening . ^^^ |
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| Interacting proteins: P51654 and P01344 |
Pubmed |
SVM Score :0.0 |
| Contrarily , GPC 3 expression prevented the increase of MMP 2 activity induced by IGF 2 . ^^^ |
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| Interacting proteins: P51654 and P01344 |
Pubmed |
SVM Score :0.0 |
| Molecular analysis of IGF 2 , GPC 3 , and FGFR 3 in the older boy yielded no abnormalities . . ^^^ |
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| Interacting proteins: P51654 and P01344 |
Pubmed |
SVM Score :0.0 |
| AIM : To investigate the expression and clinical significance of DEK , cyclin D 1 , insulin like growth factor 2 ( IGF 2 ) , glypican 3 ( GPC 3 ) , ribosomal phosphoprotein 0 ( rpP 0 ) mRNA in hepatocellular carcinoma ( HCC ) and its paraneoplastic tissues . ^^^ METHODS : The expression of mRNAs of DEK , cyclin D 1 , IGF 2 , GPC 3 and rpP 0 mRNA was detected in HCC and its paraneoplastic tissues by multiplex RT PCR . ^^^ RESULTS : By the simplex RT PCR , the overexpression of mRNAs of DEK , cyclin D 1 , IGF 2 , GPC 3 , rpP 0 mRNA in HCC and its paraneoplastic tissues was 78 . 1 % , 87 . 5 % , 87 . 5 % , 75 . 0 % , 81 . 3 % and 15 . 6 % , 40 . 6 % , 37 . 5 % , 21 . 9 % , 31 . 3 % respectively ( P < 0 . 05 ) . ^^^ The positive expression of mRNAs of DEK , cyclin D 1 , IGF 2 , GPC 3 , rpP 0 in well and poorly differentiated HCC was 89 . 0 % , 66 . 7 % , 66 . 7 % , 66 . 7 % , 77 . 8 % and 73 . 9 % , 95 . 7 % , 95 . 7 % , 95 . 7 % , 82 . 6 % , respectively ( P > 0 . 05 ) . ^^^ CONCLUSION : The expression of DEK , cyclin D 1 , IGF 2 , GPC 3 , rpP 0 mRNA in HCC is much higher in HCC than in its paraneoplastic tissues . ^^^ |
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| Interacting proteins: P51654 and P01344 |
Pubmed |
SVM Score :0.0 |
| Since BWS has been associated with biallelic expression of insulin like growth factor 2 ( IGF 2 ) , it has been proposed that GPC 3 is a negative regulator of IGF 2 . ^^^ The degree of developmental overgrowth of the GPC 3 deficient mice is similar to that of mice deficient in IGF receptor type 2 ( IGF2R ) , a well characterized negative regulator of IGF 2 . ^^^ Unlike the IGF2R deficient mice , however , the levels of IGF 2 in GPC 3 knockouts are similar to those of the normal littermates . . ^^^ |
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| Interacting proteins: P51654 and P01344 |
Pubmed |
SVM Score :0.0 |
| However , all samples that expressed GPC 3 also expressed IGF 2 , coding for a growth factor important in the survival and growth of many cancer types . ^^^ |
|
| Interacting proteins: P51654 and P01344 |
Pubmed |
SVM Score :0.0 |
| In Gpc3 / DeltaH19 double mutants ( lacking GPC 3 and also carrying a deletion around the H 19 gene region that causes bialellic expression of the closely linked Igf 2 gene by imprint relaxation ) , the Gpc 3 null phenotype was exacerbated , while additional SGBS 1 features ( omphalocele and skeletal defects ) were manifested . ^^^ However , results from a detailed comparative analysis of growth patterns in double mutants lacking GPC 3 and also IGF 2 , IGF 1 , or the type 1 IGF receptor ( IGF1R ) provided conclusive genetic evidence inconsistent with the hypothesis that GPC 3 acts as a growth suppressor by sequestering or downregulating an IGF ligand . ^^^ |
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| Interacting proteins: P51654 and P01344 |
Pubmed |
SVM Score :0.0 |
| Moreover , we report on a new patient with a GPC 3 deletion and IGF 2 evaluation . . ^^^ |
|
| Interacting proteins: P51654 and P01344 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51654 and P01344 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51654 and P01344 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51654 and P01344 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51654 and P01344 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51654 and P01344 |
Pubmed |
SVM Score :0.0 |
| NA |
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