Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.70065458
In the controls , IGF 2 was associated primarily with IGFBP 3 and to a lesser extent with IGFBP 2 , whereas in GHD the reverse was found . 0.70065458^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.7721895
In vitro studies indicate that IGF 2 in complex with IGFBP 2 has high affinity for bone matrix and is able to stimulate osteoblast proliferation . 0.7721895^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.64516269
However , in the presence of IGFs , IGFBP 2 binding to ECM was markedly enhanced , with IGF 2 being more effective than IGF 1 . 0.64516269^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
The present study characterized the changes in concentrations of insulin like growth factors 1 and 2 ( IGF 1 and IGF 2 ) in uterine luminal flushings , and the endometrial mRNA levels of IGF 1 , IGF 2 , and IGF binding protein 2 ( IGFBP 2 ) obtained from Days 0 through 18 of the bovine estrous cycle and early pregnancy . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Secretion of insulin like growth factor 2 ( IGF 2 ) and IGF binding protein 2 by intestinal epithelial ( IEC 6 ) cells : implications for autocrine growth regulation . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
IGF binding protein 2 gene expression and the location of IGF 1 and IGF 2 in fetal rat lung . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
The temporal patterns of endometrial expression for mRNAs encoding insulin like growth factor 1 ( IGF 1 ) , IGF 2 , IGF binding protein 2 ( IGFBP 2 ) , and the type 1 IGF receptor ( IGF IR ) were elucidated in cyclic and pregnant pigs . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Samples were analysed for glucose , blood urea nitrogen ( BUN ) , non esterified fatty acids ( NEFA ) , creatinine , insulin , insulin like growth factor 1 ( IGF 1 ) and IGF 2 , tri iodothyronine ( T 3 ) , progesterone and IGF binding protein 2 ( IGFBP 2 ) to determine whether rbPL mediates similar metabolic effects to those of bGH . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Coordinated pattern of expression and localization of insulin like growth factor 2 ( IGF 2 ) and IGF binding protein 2 in the adult rat brain . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Six Holstein cows were used in a complete block design to examine effects of period of lactation and somatotropin ( bST ) administration on concentrations of insulin , insulin like growth factors ( IGF 1 , IGF 2 ) , and IGF binding protein 2 ( IGFBP 2 ) . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
IGF 2 and IGF binding protein 2 mRNAs were regulated by E and P 4 distinct from IGF 1 mRNAs . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Ontogeny of growth hormone ( GH ) , insulin like growth factors ( IGF 1 and IGF 2 ) and IGF binding protein 2 ( IGFBP 2 ) in genetically lean and obese swine . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
This study compared levels of the IGF 1 and IGF 2 , and of the IGF binding protein 2 ( IGFBP 2 ) and IGFBP 3 in vitreous from three groups with different degrees of retinal ischemia , as judged by the extent of neovascularization : a control group without new vessel formation , retinal neovascularization in patients with proliferative diabetic retinopathy , and massive ischemia of various causes resulting in rubeosis . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Insulin like growth factor 2 ( IGF 2 ) , type 2 IGF receptor , and IGF binding protein 2 gene expression in rat lung alveolar epithelial cells : relation to proliferation . ^^^ Insulin like growth factor 2 ( IGF 2 ) , type 2 IGF receptor , and IGF binding protein 2 gene expression in rat lung alveolar epithelial cells : relation to proliferation . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Immunohistochemical localization of insulin like growth factor 2 ( IGF 2 ) and IGF binding protein 2 during development in the rat brain . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Insulin like growth factor 2 ( IGF 2 ) and IGF binding protein 2 ( IGFBP 2 ) were measured in amniotic fluid , extraembryonic fluid and maternal serum from 20 women with apparently normal first trimester pregnancies prior to termination . ^^^ Insulin like growth factor 2 ( IGF 2 ) and IGF binding protein 2 ( IGFBP 2 ) were measured in amniotic fluid , extraembryonic fluid and maternal serum from 20 women with apparently normal first trimester pregnancies prior to termination . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Circulating IGF 1 correlated negatively and IGF binding protein 2 ( IGFBP 2 ) positively with IGF 2 levels , suggesting that IGF 1 is displaced from IGFBPs by IGF 2 and that IGF 2 is a major regulator of IGFBP 2 . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Sera were assayed for pST , insulin like growth factor ( IGF ) 1 , IGF 2 , IGF binding protein 2 ( IGFBP 2 ) , insulin , glucose , and blood urea nitrogen ( BUN ) . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
In this study we examined expression of mRNA for IGF 1 and IGF 2 , IGF binding protein 2 ( IGFBP 2 ) , and IGF receptors 1 ( IGFR 1 ) and 2 ( IGFR 2 ) during fetal lung development and in early postnatal and adult lungs by the polymerase chain reaction ( PCR ) . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Insulin like growth factor 2 ( IGF 2 ) regulates the growth and differentiation of tissues during fetal life and is bound to a significant extent to IGF binding protein 2 ( IGFBP 2 ) in blood and tissue fluids during this period of development . ^^^ Insulin like growth factor 2 ( IGF 2 ) regulates the growth and differentiation of tissues during fetal life and is bound to a significant extent to IGF binding protein 2 ( IGFBP 2 ) in blood and tissue fluids during this period of development . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Homology search has revealed that the N terminal sequences of the 7 kDa protein and the 32 kDa protein were identical with those of insulin like growth factor 2 ( IGF 2 ) and IGF binding protein 2 ( IGFBP 2 ) , respectively . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Expression of insulin like growth factor 2 ( IGF 2 ) , IGF binding protein 2 and myogenin during differentiation of myogenic satellite cells derived from the turkey . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
The presence of IGF 2 and IGF binding protein 2 in conditioned medium was shown by Western immunoblot . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Insulin like growth factor 1 ( IGF 1 ) , IGF 2 , IGF binding protein 2 ( IGFBP 2 ) , and IGFBP 3 were elevated 3 to 13 fold in nondiabetic retinal ischemia and 1 . 5 to 3 fold in PDR , indicating that the changes were not restricted to diabetes . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
The insulin clamp resulted in alterations in circulating insulin like growth factor ( IGF ) 1 concentrations ( increase ) as well as IGF 2 and IGF binding protein 2 concentrations ( decreases ) . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Plasma concentrations of insulin and IGF 1 were also increased , but pST reduced IGF 2 and IGF binding protein 2 . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Follicular dominance in cattle is associated with divergent patterns of ovarian gene expression for insulin like growth factor ( IGF ) 1 , IGF 2 , and IGF binding protein 2 in dominant and subordinate follicles . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Increased levels of insulin like growth factor 2 ( IGF 2 ) and IGF binding protein 2 are associated with malignancy in sporadic adrenocortical tumors . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
To gain some insights into the mechanisms involved , we studied the effects of RA on the expression of several components of the insulin like growth factor ( IGF ) system that have been shown to be associated with the growth arrest of type 2 cells , mainly the IGF binding protein 2 ( IGFBP 2 ) , IGF 2 , and the type 2 IGF receptor . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
We have therefore investigated the effects of insulin like growth factor 1 ( IGF 1 ) , IGF 2 , IGF binding protein 2 ( IGFBP 2 ) and intact IGFBP 3 on in vitro sperm motility . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Insulin like growth factor ( IGF ) 1 , IGF 2 , IGF binding protein 2 and pregnancy associated glycoprotein mRNA in pigs with somatotropin enhanced fetal growth . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
In the present study , we determined whether expression of the messenger ribonucleic acids ( mRNAs ) for insulin like growth factor 2 ( IGF 2 ) , and its principal IGF type 1 receptor and IGF binding protein 2 ( IGFBP 2 ) , as well as basic fibroblast growth factor ( bFGF ) , was developmentally regulated in the baboon fetal adrenal gland . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Complex mediation of uterine endometrial epithelial cell growth by insulin like growth factor 2 ( IGF 2 ) and IGF binding protein 2 . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
In the SF , the following parameters were determined : Interleukin 1 beta , IL 6 , IL 8 , IL 1 RA , TNF alpha , Insulin like growth factor 1 ( IGF 1 ) , IGF 2 , IGF binding protein 2 ( IGFBP 2 ) , IGFBP 3 as well as total proteinase activity and total collagenase activity . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
The xenografts precisely reproduced the dysregulation of the insulin like growth factor ( IGF ) system [ overexpression of the IGF 2 and IGF binding protein 2 ( IGFBP 2 ) genes ] typical of adrenocortical carcinoma . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Ovarian follicular concentrations of activin , follistatin , inhibin , insulin like growth factor 1 ( IGF 1 ) , IGF 2 , IGF binding protein 2 ( IGFBP 2 ) , IGFBP 3 , and vascular endothelial growth factor in spontaneous menstrual cycles of normal women of advanced reproductive age . ^^^ FF was analyzed for estradiol , progesterone , testosterone , androstenedione , inhibin A and B , total activin A , total follistatin , insulin like growth factor 1 ( IGF 1 ) , IGF 2 , IGF binding protein 2 ( IGFBP 2 ) , IGFBP 3 , and vascular endothelial growth factor ( VEGF ) concentrations . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Decreased expression of IGF 2 and its binding protein , IGF binding protein 2 , in genital skin fibroblasts of patients with complete androgen insensitivity syndrome compared with normally virilized males . ^^^ RIA and RT PCR demonstrated that the genital skin fibroblast strains expressed IGF 2 , IGF binding protein 2 , and IGF binding protein 3 , but no IGF 1 . ^^^ In conclusion , although the mechanism underlying these differences requires further study , it is conceivable that in addition to the endocrine actions of IGF 1 , IGF 2 and IGF binding protein 2 , as local growth factors , are involved in the mediation of androgen action and growth of genital tissues . . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Paradoxical elevations in serum IGF 2 and IGF binding protein 2 in acromegaly : insights into the regulation of these peptides . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
We have demonstrated that HCAO patients have a specific increase in circulating big IGF 2 ( IGF IIE ) and IGF binding protein 2 ( IGFBP 2 ) levels , and that IGF IIE and IGFBP 2 circulate together in a bioavailable , 50 kDa complex . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
In this prospective , observational study IGF 1 , IGF 2 , IGF binding protein 2 , IGF binding protein 3 , and acid labile subunit were measured by immunoassays in the wound fluid and plasma of young ( 23 . 5 + / 3 . 3 years ) and elderly ( 78 . 9 + / 6 . 2 years ) patients before and daily for 4 days after elective surgery . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
In vivo processed fragments of IGF binding protein 2 copurified with bioactive IGF 2 . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Actions of GnRH antagonists on IGF 2 , IGF binding protein 2 and pregnancy associated plasma protein A in human granulosa lutein cells . ^^^ Since controversy exists on the action of GnRH agonists in the human ovary , we also tested the effect of triptorelin on IGF 2 , IGF binding protein 2 ( IGFBP 2 ) and pregnancy associated plasma protein A ( PAPP A ) in cultured human granulosa lutein cells . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Stimulation of the podocyte cell monolayers with IGF 2 resulted in a slight increase in mitogenesis , an effect that was concentration and time dependent and abrogated by co incubation with exogenous IGF binding protein 2 ( IGFBP 2 ) . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
To elucidate the potential molecular mechanisms leading to the increase in adrenal growth , we examined adrenal expression of the cell cycle regulatory proteins ( cyclin D 1 ) and cyclin kinase inhibitory proteins ( p16ink , p21Cip ) , and insulin like growth factor 2 ( IGF 2 ) , IGF binding protein 2 ( IGFBP 2 ) and IGF 1 type 1 Receptor ( IGF1R ) from fetuses infused with metyrapone or vehicle for 15 days . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Cord blood samples were analyzed for IGF 1 , IGF 2 , IGF binding protein 2 , and ghrelin . ^^^ RESULTS : The Delta birth weight was positively correlated with Delta IGF 1 ( r = 0 . 66 ; P < 0 . 0002 ) and negatively correlated with Delta IGF binding protein 2 levels ( r = 0 . 68 ; P < 0 . 001 ) but with neither Delta IGF 2 nor Delta ghrelin . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
IGF binding protein 2 ( IGFBP 2 ) has a high affinity for IGF 2 and tightly regulates IGF 2 availability during fetal and early neonatal growth . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
This results in sequestration of IGFBP 3 and predominant association of big IGF 2 with IGFBP 2 and 3 in the 50 kD complex . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
On size separation , most of the IGF 2 ( greater than 60 % ) eluted with IGFBP 2 and the other low mol wt IGFBPs . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
N nitrosomethyl urea ( NMU ) induced rat mammary tumors synthesize mRNAs for IGF 2 and IGFBP 2 , 3 , and 4 . ^^^ In contrast , normal lactating breast contains only IGFBP 2 and IGF 2 messages ; IGFBP 3 and 4 mRNAs are absent in this tissue . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Northern blots revealed mRNAs for IGF 2 , IGF binding protein 2 ( IGFBP 2 ) , and IGFBP 3 in all oviductal and endometrial tissues . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
To determine whether chronic hypoxemia results in alterations in endocrine function that may contribute to growth failure , we measured growth hormone ( GH ) , somatomedins ( insulin like growth factors 1 and 2 , IGF 1 and IGF 2 ) , hepatic growth hormone receptors , and circulating IGF binding proteins IGFBP 3 and IGFBP 2 in 12 newborn lambs with surgically created pulmonic stenosis and atrial septal defect , and in 10 controls . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
CONCLUSIONS : These observations indicate 1 ) that IGF binding proteins secreted by lung tumors are encoded by at least three different genes ; 2 ) that there may be a close association between IGF 2 and IGFBP 2 gene expression , such that , where there is production of IGF 2 , IGFBP 2 is the principal BP ; and 3 ) that the IGF 2 gene is more widely expressed than the IGF 1 gene in human lung tumor cell lines . . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Here we compare the sites of expression during early rat embryogenesis of the genes encoding the RGD containing IGF binding protein IGFBP 2 and IGF 2 . ^^^ At all ages from early post implantation through mid gestation , the expression of IGFBP 2 was highly complementary to IGF 2 . ^^^ IGFBP 2 mRNA was detected throughout the epiblast of the egg cylinder as early as e 7 , when IGF 2 expression was restricted to trophectoderm and other extraembryonic cells . ^^^ As gastrulation proceeded , IGFBP 2 expression ceased as IGF 2 expression began in the newly formed embryonic and extra embryonic mesoderm , but was retained in other epiblast derivatives including the surface ectoderm and neuroectoderm , throughout its rostral caudal extent . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
We have used in situ hybridization to localize transcripts for both insulin like growth factor binding protein 2 ( IGFBP 2 ) and its ligands , the insulin like growth factors 1 and 2 ( IGF 1 and IGF 2 ) , within limb buds of rat embryos 10 16 days after conception ( equivalent to stages 1 12 of mouse limb morphogenesis , Wanek et al , 1989 . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Sheep fibroblasts produced seven IGFBPs : a 36 . 5 41 kDa protein induced in vitro by IGF 1 , likely representing oIGFBP 3 ; a 28 . 5 kDa protein that reacted with antisera to human IGFBP 2 , likely representing oIGFBP 2 ; 25 and 27 kDa proteins induced in fetal fibroblasts by IGF 1 ; a 22 kDa protein that was inhibited by IGF 1 , likely representing oIGFBP 4 ; and 21 and 23 kDa proteins labelled only by IGF 2 , suggesting their similarities to IGFBP 6 . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
IGFBP 2 has a higher affinity for IGF 2 than for IGF 1 and its affinity for both forms of IGF is greater than for human IGFBP 1 . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
The basal plate of the term human placenta showed a similar pattern , with a superficial layer of cytotrophoblasts containing IGF 2 mRNA anatomically apposed to a deeper layer of cells expressing IGFBP 2 mRNA . ^^^ These findings suggest that IGFBP 2 may be an important modulator of IGF 2 action in placental development . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
We studied the relationship of serum insulin like growth factor 1 ( IGF 1 ) , IGF 2 , the IGF binding proteins IGFBP 1 , IGFBP 2 , and IGFBP 3 , and GH binding protein ( GHBP ; which is postulated to be derived from the extracellular portion of the GH receptor ) in normal volunteers and patients with anorexia nervosa before and after a refeeding program . ^^^ Both serum IGF 1 and IGF 2 were positively correlated with serum IGFBP 3 and negatively correlated with serum IGFBP 1 and IGFBP 2 . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Hypophysectomy significantly decreased IGFBP 3 , IGF 1 , and IGF 2 in nonpregnant mouse serum , increased the amount of IGFBP 2 found in pregnant mouse serum , and had no effect on IGF 1 or 2 concentration in day 14 pregnant mouse serum . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
One of these binding proteins , IGFBP 2 , is present at high levels in fetal rat plasma and binds both IGF 1 and IGF 2 with high affinity . ^^^ We here have used in situ hybridization to compare the distribution of IGFBP 2 mRNA with that of IGF 2 mRNA in embryonic day 13 . 5 15 rat embryos . ^^^ The spatial patterns of IGF 2 and IGFBP 2 expression in the fetal trunk were distinct and , in general , nonoverlapping . ^^^ Most mesoderm derivatives that express IGF 2 at high levels contained little , if any , IGFBP 2 mRNA . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Cells exposed to des 3 IGF 1 produced 40 60 % less IGFBP 2 whereas insulin and IGF 2 did not stimulate significant IGFBP 2 production . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
The results demonstrate specific changes in liver IGF 1 and IGFBP 2 gene expression and brain IGF 2 gene expression in animals that are growth retarded because of a restriction of dietary energy . . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
The two BPs isolated from serum , which correspond to the 32 30K CSF BP and IGFBP 2 , had affinities for IGF 2 and IGF 1 similar to those of the CSF BPs . ^^^ In the case of the 32 30K BP , these preferentially bind IGF 2 ; in the case of IGFBP 2 , their binding of the two IGFs is similar . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
The binding affinities of seven analogues of recombinant human insulin like growth factor 2 ( hIGF 2 ) were characterized for the IGF type 1 and type 2 receptors and insulin receptors , as well as for IGF binding protein ( IGFBP ) 1 , IGFBP 2 , IGFPB 3 and human serum IGFBPs . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Insulin like growth factor binding protein 2 ( IGFBP 2 ) is one of a family of IGFBPs that are present in extracellular fluids , and binds both IGF 2 and IGF 1 with high affinity . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
As assessed by solution hybridization , UA lig fetuses exhibited significantly higher hepatic IGFBP 1 , IGFBP 2 , and IGF 2 transcript abundance than UA nonlig controls ( increased 110 , 50 , and 31 % , respectively ) . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
The small complex of tumor sera contains increased amounts of IGFBP 2 and 3 , and two to threefold elevated IGF 2 . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
The fetal expression pattern of high IGF 2 and IGFBP 2 is replaced by the adult pattern of low levels of IGF 2 and IGFBP 2 and high levels of IGF 1 and IGFBP 3 . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Expression of IGF 2 , the IGF II / mannose 6 phosphate receptor and IGFBP 2 during rat embryogenesis . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
To test the hypothesis that growth hormone ( GH ) insensitivity is responsible , amongst other mechanisms , for impaired growth in uraemic children , insulin like growth factor 1 ( IGF 1 ) , IGF 2 , IGF binding protein 1 ( IGFBP 1 ) , IGFBP 2 and IGFBP 3 were measured by radioimmunoassay in normal control children , in patients with end stage renal failure ( n = 51 ) and in patients with preterminal chronic renal failure ( n = 11 ) and the production rate of IGF was calculated . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
We examined regulation of the genes for IGF 1 , IGF 2 , IGFBP 1 , and IGFBP 2 in fetal rat liver in an experimental model for intrauterine growth retardation caused by maternal fasting on days 17 21 of gestation . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
We have examined the IGFBPs secreted by monolayer cultures of neonatal fibroblasts by ligand blotting with [ 125I ] IGF 2 and immunoblotting with antisera raised against three well characterized IGFBPs : IGFBP 1 , IGFBP 2 , and IGFBP 3 . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Chinese hamster ovary ( CHO ) cells stably transformed with the IGFBP 2 cDNA secreted a 36 kd protein which bound , with different affinities , IGFII and IGFI , but did not bind insulin . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
In contrast , the fetal mRNA expression patterns of IGF 1 , IGF 2 and IGFBP 2 , 3 , 4 , 5 and 6 were not grossly altered by maternal diabetes . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Characterization of the IGF system [ IGF 1 , IGF 2 , type 1 IGF receptor , and six IGF binding proteins ( IGFBPs ) 1 6 ] revealed that IEC 6 cells express high levels of type 1 IGF receptor mRNA , low or undetectable levels of IGF 1 and IGF 2 mRNAs , and mRNA for only one of the six IGFBPs , IGFBP 2 . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
These results indicate that the expression of IGF 2 , IGFBP 2 , and IGFBP 6 is regulated in a differentiation dependent manner in Caco 2 cells . . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
To determine the developmental expression and localization of mRNA for insulin like growth factor binding protein 2 ( IGFBP 2 ) , a major binding protein of IGF 1 and IGF 2 , in ocular tissues of the embryonic and early posthatched chick . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Insulin like growth factors 1 ( IGF 1 ) and 2 ( IGF 2 ) and their binding proteins ( IGFBP 1 , IGFBP 2 and IGFBP 3 ) were measured by radioimmunoassay in plasma and milk samples collected throughout the study . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Levels of IGFBP 2 were substantially elevated in serum from Wilms ' tumour patients ( 1025 + / 112 ng / ml compared with 416 + / 44 ng / ml in controls ) , and inversely correlated with the levels of high molecular weight forms of IGF 2 . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
The genes for IGF 1 and IGF 2 , IGFBP 2 , insulin receptor , and type 1 and 2 IGF receptors were detected . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
The gene expression of insulin like growth factor 2 ( IGF 2 ) and insulin like growth factor binding protein 2 ( IGFBP 2 ) has previously been demonstrated in rat and human choroid plexus by in situ hybridization analysis . ^^^ In the present study we have characterized IGF 2 and IGFBP 2 transcripts and proteins in primary cultures of epithelial cells from lateral choroid plexus of sheep brain . ^^^ Northern blot analysis of total RNA showed one major IGF 2 mRNA of 4 . 8 kb and four minor IGF 2 transcripts of 1 . 5 , 2 . 0 , 3 . 0 and 6 . 0 kb as well as one IGFBP 2 transcript of 1 . 7 kb . ^^^ Western immunoblot analysis of conditioned medium with antibodies toward IGF 2 and IGFBP 2 demonstrated proteins with M ( r ) 6 kDa and 32 kDa , respectively . ^^^ In conclusion , cultured sheep choroid plexus epithelial cells synthesize and secrete IGF 2 and IGFBP 2 , suggesting that the choroid plexus epithelium is the main source of these polypeptides in the cerebrospinal fluid . . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
We report ( 1 ) an increase in serum IGF 2 concentrations ( about 2 fold ) , whereas IGF 1 concentrations are regarded as normal when aging is taken into account ; ( 2 ) an apparent increase in serum IGFBP 3 levels when compared to those of healthy elderly subjects , IGFBP 3 only being detected in the 150 kDa IGFBP ternary complex as in normal serum ; ( 3 ) abnormally elevated serum IGFBP 2 levels taking into account the apparent concentrations of IGFBP 3 . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
In situ hybridization analysis revealed that IGF 2 , IGFBP 5 , and IGFBP 6 mRNAs were localized in the stromal component of the tumor , whereas IGFBP 2 mRNA was expressed by epithelial cells . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
This proliferation arrest is associated with increased expression of IGFBP 2 mRNA and with induction of type 2 IGF receptor and IGF 2 mRNAs . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
IGF 1 and IGF 2 had no effect on IGFBP 2 steady state transcript levels but enhanced the level of IGFBP 5 transcripts ( approximately fourfold ) . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Our results showed that IGF 1 , IGF 2 , IGFBP 2 and 3 mRNAs were expressed in uterine fibroids , and that IGFBP 1 mRNA or protein was not detected in fibroids . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
In all subjects a single blood sample was drawn for IGF 1 , IGF 2 , IGFBP 1 , IGFBP 2 , IGFBP 3 and GH measurements by specific RIAs . ^^^ Serum levels of IGF 2 were normal in all three groups ( 588 + / 240 micrograms / l ) whereas IGFBP 1 and IGFBP 2 levels were low and IGFBP 2 levels decreased significantly with increasing serum GH levels ( P < 0 . 0001 ) . ^^^ As IGF 2 is normal and IGFBP 1 and IGFBP 2 are inversely correlated to the serum GH levels in the acromegalic patients , we speculate that the molar ratio between IGF 1 and IGFBP 3 reflects free ( biologically active ) IGF 1 and is dependent on GH levels . . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
We have recently suggested that the bioavailability of circulating IGF 1 is increased in the human fetus due to the molar excess of IGF 1 plus IGF 2 relative to IGFBP 3 as well as the increased concentrations of IGFBP 2 , which does not form a long lived ternary complex . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
These data suggest a role for IGFBP 2 in the IGF 2 dependent growth of Wilms ' tumor and in the developing kidney . . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
The ASM cells secrete IGF 2 and IGFBP 2 , and the latter could modulate the actions of the IGFs in these cells . . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
IGFBP 2 levels were increased 6 to 7 fold following incubation with IGF 1 , IGF 2 or insulin for 48 h . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Upon formation of the S shape nephron , IGFBP 2 mRNA was expressed in the committed glomerular and epithelial cells which also expressed IGF 2 and IGFBP 4 , and the mesenchyme of the vascular cleft expressed IGFBP 5 mRNA . ^^^ In the maturing glomerulus , the glomerular epithelial cells expressed IGF 2 mRNA together with IGFBP 2 and IGFBP 4 mRNAs , while IGFBP 5 mRNA was localized to the mesangium and supporting mesenchyme . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Circulating concentrations of IGF 1 decreased nearly 50 % , IGF 2 decreased 28 % and IGFBP 2 increased 49 % during the 2 d of feed deprivation . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
The changes in plasma levels of IGFBP 2 were positively related to changes in IGF 2 while there was a negative relationship between circulating IGF 1 and IGFBP 2 such that both IGF 1 and IGF 2 may play a role in the regulation of IGFBP 2 in serum . . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
In the treated diabetics IGF 1 and IGF 2 were reduced ; IGFBP 2 ( only in prepubertal subjects ) and IGFBP 3 were increased . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
In control cultures , MC3T3 E 1 cells expressed the mRNAs for IGF 1 , IGF 2 , and IGFBP 2 , 4 , 5 , and 6 but not IGFBP 1 or 3 . ^^^ A 24 h treatment with bFGF at 10 ( 8 ) M decreased IGF 1 mRNA by 97 % , IGF 2 mRNA by 73 % , IGFBP 2 by 64 % , IGFBP 4 by 73 % , IGFBP 5 by 95 % , and IGFBP 6 by 65 % . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
We conclude that prostatic stromal cell strains isolated from patients with BPH hyperexpress the mRNA for IGF 2 and IGFBP 5 while expressing reduced amounts of IGFBP 2 mRNA . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
In contrast , IGFBP 2 protein levels were consistently decreased ( 75 + / 14 % ) after 72 hr of exposure to IGF 2 without corresponding decreases in IGFBP 2 mRNA levels . ^^^ Immunoblot analysis of CM from cells treated with IGF 2 indicated that the decrease in intact protein corresponded with an increase in two non IGF binding IGFBP 2 fragments of 22 and 14 kD . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
RESULTS : IGF 1 , IGF 2 , the type 1 receptor , the insulin receptor , and IGFBP 2 6 are constitutively expressed in porcine myocardium . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Serum levels of insulin like growth factor ( IGF ) binding protein 3 ( IGFBP 3 ) in healthy infants , children , and adolescents : the relation to IGF 1 , IGF 2 , IGFBP 1 , IGFBP 2 , age , sex , body mass index , and pubertal maturation . ^^^ Therefore , we measured IGFBP 3 , IGF 1 , IGF 2 , IGFBP 1 , and IGFBP 2 levels by RIA in 907 healthy children to establish well characterized normative data on IGFBP 3 according to age , sex , and pubertal stage and to study the complex relationship between IGFs and their BPs in puberty . ^^^ Concomitantly , IGF 2 and IGFBP 2 levels were unchanged throughout puberty , whereas IGFBP 1 levels declined with age in prepubertal children , with lowest values in puberty . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
The expression of insulin like growth factor 2 ( IGF 2 ) and insulin like growth factor binding protein 2 ( IGFBP 2 ) in 11 cases of hepatoblastoma was studied by means of in situ mRNA hybridization using digoxigenin ( DIG ) labeled riboprobes . ^^^ The results showed that both IGF 2 and IGFBP 2 transcripts are present in hepatoblastoma and that their expression is inversely correlated with the degree of tumor cell differentiation . ^^^ The data suggested that IGF 2 and IGFBP 2 gene expression could be regarded as a marker for assessment of the degree of differentiation in hepatoblastoma . . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Circulating IGF 2 positively correlates with circulating IGFBP 2 ( r = 0 . 48 , P = 0 . 02 ) throughout gestation and at 1 day postnatally . ^^^ These relationships are consistent with circulating IGF 1 influencing IGFBPs 3 and 4 , and similarly , IGF 2 determining IGFBP 2 , or vice versa . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
The addition of IGFBP 1 caused a 19 21 % inhibition of IGF 1 or IGF 2 stimulated migration , whereas the addition of IGFBP 2 inhibited the effect of both by greater than 60 % . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Lastly , IGFBP 2 and IGFBP 3 are mitogenic for UMR 106 . 01 rat osteosarcoma cells , inducing an increase in cell number to 125 % and 142 % of control cell counts after 48 h of incubation with 1000 ng / ml IGFBP 2 and 3 , whereas IGF 1 , IGF 2 and Long R 3 IGF 1 did not stimulate proliferation . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
In this study , we describe the mRNA expression of IGF 1 , IGF 2 , type 1 IGF receptor , IGFBP 2 , IGFBP 4 and IGFBP 5 during mouse lung development as studied by in situ hybridization techniques . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Serum levels of insulin like growth factor 1 ( IGF 1 ) , IGF 2 , and IGF binding protein 1 ( IGFBP 1 ) , IGFBP 2 , and IGFBP 3 were measured in 94 children with chronic renal failure ( CRF ) . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
IGFBP 2 production was also inhibited by IGF 2 and [ Leu 27 ] IGF 2 ( ED 50 for both 3 ng / mL ) but not by IGF 1 at up to 30 ng / mL . ^^^ In addition to IGFBP 2 , a 35 45 kDa IGFBP identified by immunoprecipitation as IGFBP 3 was variably present on ligand blots of control conditioned medium and was consistently found in medium from cells treated with IGF 1 or IGF 2 ( ED 50 3 ng / mL ) but not with insulin at 2 mg / mL . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Developmental changes in hepatic IGF 2 and IGFBP 2 mRNA levels in intrauterine growth retarded and control swine . 1 . ^^^ Developmentally , hepatic IGF 2 ( P < 0 . 05 ) and IGFBP 2 ( P < 0 . 01 ) mRNA levels were higher fetally and at birth than at 21 and 49 days of age . 3 . ^^^ This study provides new information concerning hepatic expression of IGF 2 and IGFBP 2 in developing swine . . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
In general , there was an inverse relationship with serum IGFBP 3 ( except IDDM ) and IGFBP 2 levels were high in situations where free IGF 2 should be expected to be high . ^^^ The tentative conclusion would therefore be that free IGF 2 is a major regulator of circulating IGFBP 2 . . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Northern blots of total cellular RNA were probed with oligonucleotides for IGF 1 , IGF 2 , IGFBP 2 , and IGFBP 3 and a human IGFBP 1 cDNA . ^^^ The data showed that in fibroids compared to myometrium , 1 ) the relative abundance of IGF 1 mRNA was not different , but there was an increase in the relative abundance of IGF 2 mRNA ( P < 0 . 001 ) ; 2 ) IGFBP 1 mRNA was undetectable in fibroids and detectable in only 1 specimen of myometrium ; 3 ) there was no difference in the relative abundance of IGFBP 2 mRNA , but there was an increase in the relative abundance of IGFBP 3 mRNA in myometrium ( P < 0 . 05 ) . ^^^ Our data show that the mRNAs encoding IGF 1 , IGF 2 , IGFBP 2 , and IGFBP 3 are expressed in both fibroids and myometrium and that fibroids express more IGF 2 and less IGFBP 3 mRNA than myometrium . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
IGF 2 ligand blots confirm these tissue specific differences in binding and show that each ocular tissue contains IGFBP 2 . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
We conclude that IGF 1 ( 40 micrograms / kg every 12 h ) given sc to adults with GHRD is safe ; achieves normal levels of IGF 1 ; reduces insulin , IGF 2 , and GH levels ; and increases IGFBP 2 concentrations and urinary excretion of calcium . . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Nocturnal levels of IGF 1 , IGF 2 , IGFBP 2 and IGFBP 3 remained stable during both studies . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
In the present study , we investigated IGFBP 2 effects in lung tumor cells by examining the influence of IGFBP 2 on IGF receptor interaction and the biological actions of IGF 1 and IGF 2 . ^^^ In NSCLC cells , both IGF 1 and IGF 2 bound predominantly to IGF 1 receptors , whereas in SCLC cells binding was principally to surface associated IGFBP 2 . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
After 24 h of treatment , IGF 1 , IGF 2 , and high concentrations of insulin increased IGFBP 2 and IGFBP 3 levels . ^^^ In situ hybridization studies demonstrated an increase in the abundance per cell of IGFBP 2 and IGFBP 3 mRNAs in either one or both types of astroglial cells after IGF 1 or IGF 2 treatment . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Secretion of IGFBP 2 was not regulated to a significant degree , with insulin , IGF 2 , IGF 1 , forskolin , and dibutyryl cyclic adenosine monophosphate ( cAMP ) inducing minimal changes in IGFBP 2 secretion of less than 30 % by radioimmunoassay ( RIA ) . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
IGF 1 , IGF 2 , and IGFBP 2 , 4 , 5 , and 6 mRNAs are detected in osteoblasts localized in zones of endochondral ossification from E 18 to at least P 25 . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
It has previously been demonstrated that 17 parents heterozygous for the Ecuadorean mutation of the GH receptor differed little in biochemical measures ( GHBP , IGF 1 , IGF 2 , IGFBP 2 and IGFBP 3 ) from Ecuadorean controls . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
The steady state level of the rat insulin like growth factor binding protein 2 ( IGFBP 2 ) and insulin like growth factor 2 ( IGF 2 ) mRNA increased approximately 20 fold when BRL 3A cells were cultured at increasingly higher cell densities . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
We recently reported that a majority of human colon cancers express and secrete the potent mitogen IGF 2 and at least two inhibitory binding proteins , IGFBP 2 and IGFBP 4 . ^^^ In the present study we measured the expression and secretion of IGF 2 , IGFBP 2 , and IGFBP 4 in relation to growth and differentiation of CaCo 2 human colon cancer cells , which undergo spontaneous enterocytic differentiation in culture . ^^^ While the changes in the relative protein concentrations and mRNA levels of IGF 2 and IGFBP 4 were statistically significant , the changes measured in the RNA and protein levels of IGFBP 2 were not , as a result of large inter experimental variations . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
In this study , SK N SH neuroblastoma cells were shown to produce IGF 2 , IGFBP 2 , IGFBP 4 and small quantities of IGFBP 6 . ^^^ The availability of IGF 2 to the cells may also be enhanced because of the proteolysis of IGFBP 2 to which it is bound . ^^^ Insulin like growth factor binding protein 6 has a strong affinity for IGF 2 , 5 10 times that of IGFBP 2 and at least 10 times that of the type 1 IGF receptor , and the arrested proliferation may result , at least in part , from sequestration by IGFBP 6 of the IGF 2 secreted . . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
In this study , we examined the effect of fetal exposure to alcohol IGF 1 and on IGF 2 and IGFBP 1 and IGFBP 2 mRNA in placenta and fetal lung tissue . ^^^ At G 20 , dams were killed , and we examined placenta and fetal lung for the steady state levels of mRNA for IGF 1 and IGF 2 and for IGFBP 1 and IGFBP 2 . ^^^ Multiple transcripts for IGF 1 and IGF 2 , 1 . 8 kb species for IG FBP 1 and 1 . 6 kb species for IGFBP 2 were detected from total RNA isolated from the fetal lung and placenta , Slot blot hydridization analysis of fetal lung RNA showed that IGF 1 mRNA was significantly increased ( p < 0 . 001 ) in AF males and females by 4 . 0 + / 0 . 28 fold and by 3 . 25 + / 0 . 2 fold , respectively . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
MEASUREMENTS : Serum IGF 1 , IGF 2 , IGFBP 1 , IGFBP 2 , IGFBP 3 , insulin and C peptide were measured by radioimmunoassay . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
In the patients with GHIS , chronic IGF 1 treatment , with twice daily injections for 6 months , caused a significant steady decline of IGF 2 and an increase in IGFBP 2 , but had no effect on IGFBP 1 and IGFBP 3 levels . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Serum levels of insulin like growth factor 1 ( IGF 1 ) , IGF 2 , and IGF binding protein 1 ( IGFBP 1 ) , IGFBP 2 , and IGFBP 3 were measured in 54 children with end stage renal disease ( ESRD ) . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
We investigated the expression of the mRNAs encoding IGF 1 , IGF 2 , the type 1 IGF receptor ( IGF T1R ) and two IGF binding proteins ( IGFBP 2 and IGFBP 4 ) in rat lung during the perinatum . ^^^ At day 20 of gestation IGF 1 , IGF T1R and IGFBP 4 mRNA levels were higher in lung than liver ( all P < 0 . 01 ) , whereas IGF 2 and IGFBP 2 mRNA levels were higher in liver than lung ( each P < 0 . 02 ) . ^^^ The patterns of expression of IGF 1 , IGF T1R , IGFBP 2 and IGFBP 4 , but not IGF 2 , in developing lung correspond to previously described phasic changes in lung cell proliferation rates . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
IGFBP 2 and IGFBP 4 in human intestinal epithelial cells : is it a way of modulating IGF 2 bioavailability towards the IGF responsive basolateral surface . ^^^ In early differentiated cells , i . e . , up to day 7 post confluence , IGF 2 , IGFBP 2 , IGFBP 4 ( > 96 % ) and IGFBP 6 ( approximately 85 % ) are recovered in the basolateral medium . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Recent studies demonstrate that IGF 2 in FFe is higher than in FFa ' whereas IGF 1 , IGFBP 3 and IGFBP 1 levels do not differ , underscoring the importance of local IGF 2 production by the granulosa and the importance of IGFBP 4 and IGFBP 2 in regulation of IGF 2 action within the follicle during its developmental pathway as an E 2 or A dominant follicle . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
In order to investigate the IGF regulatory pathway in leukaemia serum levels of IGF 1 , IGF 2 , IGFBP 2 and IGFBP 3 were determined in 28 leukaemic children . ^^^ Whereas serum levels of IGF 1 ( mean / range : 2 . 7 / 0 . 1 to 6 . 7 SDS ) , IGF 2 ( 3 . 6 SDS / 1 . 3 to 8 . 7 ) and IGFBP 3 ( 2 . 0 / +2 . 2 to 7 . 1 SDS ) were significantly decreased comparable to levels in growth hormone deficiency , IGFBP 2 levels ( +4 . 0 / 0 . 45 to +7 . 4 SDS ) were found to be markedly elevated and inversely correlated to IGF 1 ( r = 0 . 51 , P = 0 . 013 ) . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Expression and regulation of IGFBP 2 and IGF 2 by GH and glucose in the rat insulin producing beta cell line , INS 1 , were determined . ^^^ GH has no regulatory activities on IGF 2 or IGFBP 2 gene expression . ^^^ The levels of IGF 2 and IGFBP 2 mRNA at increasing glucose concentrations are inversely regulated and exogenously added insulin inhibits IGFBP 2 gene expression at low glucose . ^^^ These observations suggest that the expression of IGFBP 2 gene in this cell line is under the negative control of the endogenously produced insulin ( and / or IGF 2 ) which accumulates to effective levels in the medium when the cells are cultured at high glucose concentrations . . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Since IGF 2 is known to be a major regulator of IGFBP 2 , its influence on IGFBP 2 expression has to be investigated . . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Insulin like growth factor ( IGF ) binding protein 2 ( IGFBP 2 ) is secreted by several cell types that also secrete IGF 1 or IGF 2 . ^^^ The binding of IGF 1 or IGF 2 to IGFBP 2 has been shown to alter their actions . ^^^ In this study we report that IGFBP 2 binds to heparin if IGF 1 or IGF 2 is also included in the incubation buffer . ^^^ Binding appeared to be physiologically significant , as IGFBP 2 bound to human fibroblast ECM if IGF 1 or IGF 2 was added . ^^^ IGF 2 was more potent than IGF 1 in facilitating the binding interaction , and des ( 1 3 ) IGF 1 or insulin had no effect , suggesting that IGF binding to IGFBP 2 is required for this effect to be detected . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Cord sera were obtained from term , Chilean newborns exhibiting various patterns of intrauterine growth and assayed for IGF 1 , IGF 2 , IGFBP 1 , IGFBP 2 , and IGFBP 3 by specific radioimmunoassays ( RIA ) . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
The mRNA for IGF 1 , IGF 2 , IGFBP 2 , LH receptor , FSH receptor , cytochrome P 450 side chain cleavage ( P450scc ) , 3 beta hydroxysteroid dehydrogenase ( 3 beta HSD ) , 17 alpha hydroxylase ( P 45017 alpha ) , and aromatase ( P450arom ) were detected by in situ hybridization , and relative amounts were determined by image analysis . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Factors contributing to the defect are : ( 1 ) low ALS levels , secondary to suppressed growth hormone ( GH ) ; ( 2 ) defective IGFBP 3 binding to ALS ; ( 3 ) reduced ability of pro IGF 2 forms to complex normally , and ( 4 ) very high levels of other IGFBPs , including IGFBP 2 and IGFBP 6 , which might limit the formation of complexes with IGFBP 3 . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
We measured levels of maternal and cord serum IGF 1 , IGF 2 , C peptide , IGFBP 1 , IGFBP 2 and IGFBP 3 in 8 White Class B insulin dependent DP and 8 non diabetic pregnancies ( NP ) . ^^^ No significant differences were found between DP and NP with respect to cord serum IGF 2 , maternal serum IGF 1 , IGF 2 , C peptide , IGFBP 1 , IGFBP 2 and IGFBP 3 , and the concentration and affinity of TR for IN , IGF 1 and IGF 2 . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
RESULTS : ( 1 ) Compared to 100 normal weight girls of same age the obese subjects had increased levels of IGF 1 , IGFBP 1 , IGFBP 2 , and IGFBP 3 and normal levels of IGF 2 . ( 2 ) After weight loss ( 8 . 1 + / 2 . 0 kg ) IGF 2 and IGFBP 2 increased and IGF 1 , IGFBP 1 , IGFBP 3 and the ratio IGF I / IGFBP 3 decreased significantly . ( 3 ) Correlation analysis revealed that fasting insulin levels of the patients were positively correlated with IGF 1 but inversely with IGFBP 1 and IGFBP 2 . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Under basal conditions , SH SY5Y cells in serum free medium secreted IGF 2 , and traces of IGF 1 , IGFBP 2 and IGFBP 4 . ^^^ After 48 h , when IGFBP 2 and IGFBP 4 concentrations in the culture media had increased , des ( 1 3 ) IGF 1 remained the most active , but the activity of insulin now equalled or exceeded that of IGF 1 and IGF 2 . ^^^ This suggests a negative feedback mechanism involving partial sequestration of IGF 1 and IGF 2 by IGFBP 2 and IGFBP 4 . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Forty three pediatric IDDM patients were randomly assigned to groups receiving daily , fasting subcutaneous injections of placebo or rhIGF 1 ( 80 micrograms . kg . day ) for 28 days , while continuing to receive splitmix insulin therapy and intensive outpatient management . rhIGF 1 therapy corrected IGF 1 deficiency , suppressed IGFBP 1 levels ( P < 0 . 01 ) , and induced a trend toward lower circulating GH levels throughout the study . rhIGF 1 therapy also induced an approximate 50 % decrease in IGF 2 levels ( P < 0 . 001 ) and an approximate 70 % increase in IGFBP 2 levels ( P < 0 . 05 ) . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Serum PSA ( by EIA ) , and IGFBP 2 , IGFBP 3 , IGF 1 and IGF 2 ( by RIA ) were measured in all subjects , and serially in patients with PC . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Following a five day maternal fast , both IGF 1 and IGF 2 levels were decreased in the maternal and fetal circulation ( P < 0 . 05 ) , accompanied by a decrease in fetal hepatic IGF 1 mRNA levels , but the IGFBP 2 level was increased and the IGFBP 3 level was decreased in maternal circulation , whereas the IGFBP 1 level was increased in fetal circulation . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Serum PSA ( by EIA ) , and IGFBP 2 , IGFBP 3 , IGF 1 and IGF 2 ( by RIA ) were measured in all subjects , and serially in patients with PC . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Under basal conditions , neuroblastoma cells secrete IGFs ( essentially IGF 2 ) , IGFBPs ( IGFBP 4 and predominantly IGFBP 2 that is partially proteolysed ) , and proteases , including tissue type plasminogen ( PLG ) activator , whose activity is inhibited by PLG activator inhibitor 1 . ^^^ There was a parallel increase in IGFBP 2 proteolysis , which resulted in a 5 fold loss of affinity for IGF 2 . ^^^ Therefore , IGF 2 mediates autocrine proliferation in neuroblastoma cells under the control of IGFBPs secreted by the cells , its bioavailability being enhanced as a result of plasmin induced IGFBP 2 proteolysis . . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
This study investigated the expression of the mRNA encoding the insulin like growth factors ( IGF ) and IGF binding proteins ( IGFBP ) and have demonstrated IGF 2 , IGFBP 2 , and IGFBP 3 to be altered . ^^^ Apart from their expression in the displaced metanephric blastema , both IGF 2 and IGFBP 2 were overexpressed in abnormal tissue elements in all kidneys from fetal to postnatal life . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Fetal hepatic IGFBP 1 mRNA levels increased in 4 of 6 nephrectomized fetuses , while those of IGF 1 , IGF 2 , IGFBP 2 were unchanged . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Fasting levels of IGF 1 , free IGF 1 , IGF 2 , IGFBP 3 , and insulin increased significantly within 3 months of GH treatment , whereas IGFBP 1 , IGFBP 2 , and IGFBP 6 showed no change . ^^^ IGFBP 3 and IGF 2 both showed late ( > 20 h ) responses to a dose of GH , whereas IGFBP 2 and IGFBP 6 showed minimal changes . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
In the tissues , IGFBP 2 mRNA was expressed in all normal and cancer samples but other IGFBPs showed variable expression . mRNAs for IGF 1 were expressed in all normal and cancer tissues but IGF 2 mRNA was only detected in cancer tissue ( 3 out of 10 ) . ^^^ Immunostaining of sections of normal and cancer tissue was negative for IGF 1 and IGF 2 ; IGFBP 2 was positive in 2 out of 10 cancer tissues and 7 out of 10 normal tissues ; IGFBP 3 was positive in 7 out of 10 cancer tissues and 7 out of 10 normal tissues ; and IGFBP 4 was positive in 5 out of 10 cancer tissues and 6 out of 10 normal tissues . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
In conclusion , the data point to IGF 1 , IGF 2 , IGFBP 2 , and IGFBP 3 as putative mediators of relaxin induced uterine growth in the pig . . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
After 12 months of study , the 30 children receiving rhGH showed : ( 1 ) greater increase in height ( 9 . 1 + / 2 . 8 vs . 5 . 5 + / 1 . 9 cm , P < 0 . 0001 ) ; ( 2 ) increases in serum levels of IGF 1 , IGF 2 , free IGF 1 , IGFBP 3 and acid labile subunit ( ALS ) ; ( 3 ) a greater decrease in serum IGFBP 1 levels ; and ( 4 ) no significant difference in serum IGFBP 2 levels , when compared to the 14 control patients . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Immunological determination of IGFBP 2 , IGFBP 3 , IGF 1 , IGF 2 , interleukin 1 beta ( IL 1 beta ) and tumour necrosis factor alpha ( TNF alpha ) was undertaken in the SF and plasma of 115 patients with rheumatoid arthritis ( RA ; n = 53 ) , osteoarthritis ( OA ; n = 44 ) and other rheumatic disorders . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
We propose that low IGFBP 2 levels in combination with increased levels of IGF 2 would result in more free IGF 2 and consequently greater stimulation of proliferation . . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Spontaneous GH secretion , IGF 1 , free IGF 1 ( fIGF 1 ) , IGF 2 , their binding proteins ( IGFBP 1 , IGFBP 2 , and IGFBP 3 ) , and GH binding protein ( GHBP ) values at the time of clinical diagnosis ( n = 65 ) , after a 25 % decrease in the body mass index ( BMI ) expressed as the SD score ( BMI SD score ; n = 29 ) , and after a diminution of at least 50 % of the initial BMI SD score ( n = 9 ) are reported . ^^^ IGFBP 2 correlated significantly with IGF 2 only in the obese group at diagnosis ( r = 0 . 760 ; P < 0 . 0001 ) , but with fIGF 1 in all groups . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
We report their spontaneous GH secretion and IGF 1 , free IGF 1 ( fIGF 1 ) , IGF 2 , the IGF binding proteins ( IGFBP 1 , IGFBP 2 , and IGFBP 3 ) , and GH binding protein ( GHBP ) levels at the time of the clinical diagnosis ( n = 50 ) and after recuperation of between 6 8 % ( n = 42 ) and 10 % or less of the initial weight ( n = 20 ) . ^^^ Serum IGFBP 2 levels had a strong negative correlation with fIGF 1 , IGF 2 , and the sum of IGF 1 and IGF 2 , but only at the time of diagnosis . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Multiple regression analysis showed that maternal weight gain was negatively associated with circulating IGF 2 and IGFBP 2 . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
By solution binding assay , truncated IGFBP 2 showed less than 10 % binding of [ 125I ] IGF 1 and 25 % binding of [ 125I ] IGF 2 at pH 7 . 0 compared with rhIGFBP 2 . ^^^ The IGF 2 association constant for truncated IGFBP 2 ( 6 . 5 nM ( 1 ) ) was 10 fold lower than that for intact IGFBP 2 ( 58 nM ( 1 ) ) . ^^^ Des ( 1 6 ) IGF 2 was totally inactive in displacing IGF 2 tracer from the IGFBP 2 fragment , but displaced tracer from rhIGFBP 2 with 10 % the activity of IGF 2 . ^^^ Thus , the amino terminal hexapeptide of IGF 2 is required for interaction with the carboxy terminal domain of IGFBP 2 . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
In the patients , serum concentrations of IGFBP 3 were reduced , compared with controls , with a 46 % lower mean value ; whereas levels of IGF 1 , IGF 2 , IGFBP 2 , and GH were similar in the two groups . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
HT 29 D4 cells secreted IGF 2 totally complexed to IGFBP 2 , IGFBP 4 and IGFBP 6 . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
High fetal mRNA levels were measured for IGFBP 2 , showing a similar profile in time as observed for IGF 2 . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
The temporal variations in endometrial expression of mRNA encoding insulin like growth factor 1 ( IGF 1 ) and IGF 2 , and insulin like growth factor binding protein 1 ( IGFBP 1 ) and IGFBP 2 were investigated between oestrus and day 20 of pregnancy in ewes . ^^^ Northern blot analysis of endometrial total RNA revealed major transcripts for IGF 1 ( 7 . 1 kb ) , IGF 2 ( 5 . 8 kb ) , IGFBP 1 ( 1 . 3 kb ) and IGFBP 2 ( 1 . 7 kb ) . ^^^ The low endometrial expression of mRNA encoding IGF 1 at day 15 of pregnancy was used as the reference point for time comparison for expression of mRNA encoding IGF 1 , IGF 2 and IGFBP 2 . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
As determined by specific radioimmunoassays SK N MC cells secreted 0 . 75+ / 0 . 02 ng / ml IGF 1 , 1 . 2+ / 0 . 04 ng / ml IGF 2 and 149+ / 2 . 1 ng / ml IGFBP 2 within 24 h , whereas CHP cells secreted 0 . 1+ / 0 . 01 ng / ml IGF 1 , but 6 . 2+ / 0 . 1ng / ml IGF 2 and 254 . 8+ / 5 . 5 ng / ml IGFBP 2 ( N=5 ) . ^^^ IGFBP 2 secretion correlated positively with IGF 2 secretion in CHP cells ( r=0 . 85 , P=0 . 05 ) and negatively with IGF 1 ( r= 0 . 9 , P < 0 . 01 ) in SK N MC cells . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Many of these studies have used rats , an admittedly important model , but one which differs from the human in a potentially significant way : rats lack circulating IGF 2 and IGFBP 2 during post weaning and adult life . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
The mouse C 2 myoblast cell line stably transfected with a vector producing IGF 2 antisense RNA was used to show that specific IGFBP expression changes with the state of the cells : high levels of IGFBP 2 messenger RNA ( mRNA ) were found only in proliferating myoblasts , whereas IGFBP 3 mRNA was induced in quiescent cells . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
We studied 11 elderly male ( 50 78 years ) marathon runners and 10 age matched male ( 52 73 years ) sedentary controls to evaluate plasma concentrations of GH , total and free IGF 1 and IGF 2 and of IGF binding protein 1 ( IGFBP 1 ) , IGFBP 2 , IGFBP 3 and insulin . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Here we report that locally produced IGF 2 affects IGFBP 2 expression and growth of leukemic cells through the IGF type 1 receptor . ^^^ Inhibition using an IGF 2 antibody showed that tumor cell derived IGF 2 accounts for a significant 25 % ( P < 0 . 001 ) increase in IGFBP 2 secretion and enhanced growth ( P < 0 . 01 ) of leukemic T cells after 7 days in culture . ^^^ The addition of 100 ng / ml IGF 2 enhanced the IGFBP 2 secretion 2 . 8 fold , while the use of IGF 1 only enhanced IGFBP 2 secretion 1 . 7 fold , although IGF 1 enhanced IGF 2 action . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Analysis of the conditioned medium revealed that intestinal stromal cells secreted IGF 1 , but little IGF 2 , in addition to an M ( r ) 32 , 000 IGF binding protein ( IGFBP 2 ) and an IGFBP having M ( r ) approximately 24 , 000 . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
In vitro , we found that IGF 2 enhanced by over threefold IGFBP 2 binding to extracellular matrix produced by human osteoblasts and that in an extracellular matrix rich environment , the IGF II / IGFBP 2 complex was as effective as IGF 2 alone in stimulating human osteoblast proliferation . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
In this study , testosterone , dihydrotestosterone ( DHT ) , 3 alpha androstanediol ( 3 alpha diol ) , IGF 1 , IGF 2 , IGFBP 2 , and IGFBP 3 concentrations were evaluated in human benign prostatic hyperplasia ( BPH ) tissue . ^^^ IGF 1 , IGFBP 2 , and IGFBP 3 were measured by radioimmunoassay , and IGF 2 by immunoradio metric assay , after acidification and chromatography on Sep pak C 18 Cartridges for IGF 1 and IGF 2 . ^^^ IGF 1 , IGF 2 , IGFBP 2 , and IGFBP 3 levels were 24 + / 3 . 7 , 121 + / 14 ng / g tissue and 0 . 44 + / 0 . 05 and 1 . 2 + / 0 . 17 micrograms / g tissue , respectively . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
We measured serum levels of free IGF 1 and free IGF 2 , total IGF 1 , total IGF 2 , big IGF 2 and IGFBP 1 , IGFBP 2 and IGFBP 3 in patients with NICTH before ( n=14 ) and after surgical removal of the tumour ( n=3 ) . ^^^ In accordance with earlier observations levels of total IGF 1 , total IGF 2 , and IGFBP 3 were decreased , whereas IGFBP 1 and IGFBP 2 were increased in NICTH ( all p values < 0 . 05 ) . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
The bacterially derived IGFBP 2 had a correct N terminal sequence , molecular mass on SDS PAGE and the same affinity for IGF 1 and IGF 2 as IGFBP 2 from mammalian cells . ^^^ Procedures for display and approximately 10000 fold enrichment of IGFBP 2 bearing phage using adsorption to IGF 2 coated microtitre plates were developed . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
In children with ILD , expression of IGF 1 was observed in nine patients and of IGF 2 in three patients , and the presence of IGFBP 2 was found in all extracts analysed ( mRNA and proteins ) . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
The IGF 1 ( granulosal cells ) and IGF 2 ( thecal cells ) are increased , whereas IGFBP 2 ( granulosal cells ) is reduced , in dominant follicles . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Concomitant with IGFBP 2 expression in these tumours , were a decrease in IGFBP 1 expression and an increase in IGFBP 3 proteolysis , both of which increase the bioavailability of the IGF 2 produced by the cells . ^^^ Our findings suggest that IGFBP 2 plays a role in this model of experimental tumorigenesis via a mechanism that remains unclear , but appears to involve increased protease activity and IGF 2 bioavailability . . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
No significant alterations were observed in IGF 2 or any of the binding proteins ( except IGFBP 2 ) determined by Western ligand blotting . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Insulin like growth factor binding protein 2 ( IGFBP 2 ) , the predominant IGFBP in the fetal circulation and an induced protein during several types of malignancies , belongs to a family of structurally related proteins that bind the mitogens , IGF 1 and IGF 2 . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
The injured sciatic nerve expressed IGF 1 and IGF 2 as well as IGFBP 4 and IGFBP 5 , whereas central nervous system ( CNS ) scar tissue expressed IGF 1 , IGFBP 2 , and IGFBP 5 . ^^^ In line with the in vivo findings , cultured Schwann cells expressed IGF 1 , IGF 2 , IGFBP 4 , and IGFBP 5 mRNAs , whereas cultured astrocytes expressed IGF 1 , IGFBP 2 , and IGFBP 5 mRNAs . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
The basal IGF 2 concentration was below the normal range ( 86 ng / mL ) , whereas IGFBP 2 was normal ( 258 ng / mL ) . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
The increase in IGFBP 2 , however , was only to the same extent as that of IGF 2 at most , depending on the length of treatment . ^^^ Therefore , the increase in IGFBP 2 would dampen , but not eliminate , the increased IGF 2 activities . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
We evaluated the GH bioactivity ( GH BIO ) , GH serum level by immunofluorimetric assay ( GH IFMA ) , insulin like growth factor 1 ( IGF 1 ) , IGF 2 , and IGF binding protein 1 ( IGFBP 1 ) , IGFBP 2 , and IGFBP 3 in 21 prepubertal obese children ( 13 boys and eight girls ) aged 5 . 7 to 9 . 4 years affected by simple obesity and in 32 ( 22 boys and 10 girls ) age and sex matched normal weight controls . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
All subjects underwent a 24 h GH profile ( 20 minute sampling ) , measurement of serum IGF 1 , IGF 2 , IGFBP 3 , IGFBP 2 and growth hormone binding protein ( GHBP ) and , after an overnight fast , an AST ( intravenous arginine 20 g / m2 over 30 minutes ) . ^^^ Normative data for serum IGF 1 , IGF 2 , IGFBP 3 and IGFBP 2 were obtained from 125 subjects aged 60 87 years . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Under normal physiology , IGF 2 expression is restricted to the mesenchymal support structures of the brain , including the choroid plexus , where its expression is coincident with that of IGFBP 2 . ^^^ In the CSF , transported IGF 2 is complexed to IGFBP 2 and essentially demonstrates an endocrine mode of action with a balance of locally produced IGFBPs modulating its bioactivity in the wound . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Other results were : IGF 1 , 3 11 ng / mL ( normal , 114 492 ) ; IGF 2 , 185 299 ng / mL ( normal , 358 854 ) ; IGF binding protein 1 ( IGFBP 1 ) , 12 200 ng / mL ( normal , 13 73 ) ; IGFBP 2 , 60 384 ng / mL ( normal , 55 480 ) ; and IGFBP 3 , 400 600 ng / mL ( normal , 2000 4000 ) . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Leptin , insulin , insulin like growth factor 1 ( IGF 1 ) , IGF 2 , IGF binding protein 1 ( IGFBP 1 ) , IGFBP 2 , and IGFBP 3 were measured by specific immunoassays . ^^^ IGF 2 , IGFBP 1 , and IGFBP 2 exhibited transient decreases before returning to baseline levels . ^^^ There were also significant increments in insulin , IGF 1 , and IGFBP 3 , whereas IGF 2 , IGFBP 1 , and IGFBP 2 did not change over 9 months of GH treatment . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
In AN , the levels of GH binding protein , free and total IGF 1 , free IGF 2 , and IGFBP 3 were significantly reduced ; total IGF 2 , IGFBP 2 , and IGFBP 4 levels were unchanged ; and IGFBP 1 was increased . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
IGF 2 and IGFBP 2 mRNAs were not detected in perinatal uteri . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
CONCLUSION : Twice daily rhIGF 1 therapy in adults with type 1 diabetes resulted in an increase in circulating IGF 1 with a reciprocal decrease in IGF 2 , and a marked elevation of IGFBP 2 concentration . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Both GH dosage , the increase in IGF 2 , and body mass index correlated with the decrease in IGFBP 2 . ^^^ CONCLUSION : GH significantly increased serum IGF 1 , IGF 2 , IGFBP 3 , and IGFBP 4 and decreased serum IGFBP 1 and IGFBP 2 in post menopausal women . . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
At switch from CaCo 2 cell proliferation to differentiation a marked increase in the secretion of IGF 2 ( 10 fold ) , IGFBP 1 ( 2 . 5 fold ) , IGFBP 2 ( 3 fold ) , and IGFBP 3 ( 6 fold ) was measured . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Fasting ALS , IGF 2 , IGFBP 3 , IGFBP 2 , IGFBP 1 , and insulin levels before rhIGF 1 treatment were 46 . 3 mg / L , 1044 microg / L , 5 . 8 mg / L , 73 ng / mL , 4 . 7 ng / mL , and 27 . 3 mU / L , respectively . ^^^ IGF 2 , ALS , and insulin levels were elevated , whereas IGFBP 1 and IGFBP 2 levels were decreased compared to reference values . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
IGF 2 mRNA was detected in trophoblasts invading the walls of maternal vessels , and the endothelium of the preplacental vessels expressed IGFBP 4 mRNA , while IGFBP 2 and IGFBP 5 mRNAs were present in the tunica media of mesometrial arteries that had not been invaded by trophoblast . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Furthermore , we measured serum IGF 1 , IGF 2 , IGFBP 2 , and IGFBP 3 levels in the patients . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
The concentrations measured by RIA on d 3 were 10 . 7+ / 0 . 4 ng / mL for IGF 2 , 1 . 9+ / 0 . 1 ng / mL for IGF 1 , 100+ / 5 ng / mL for IGF binding protein 3 ( IGFBP 3 ) , and 2163+ / 108 ng / mL for IGFBP 2 . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Immunohistochemical study of insulin like growth factor 2 ( IGF 2 ) and insulin like growth factor binding protein 2 ( IGFBP 2 ) in choroid plexus papilloma . ^^^ Insulin like growth factor binding protein 2 ( IGFBP 2 ) , one of the six carrier proteins for IGFs , is also thought to be released from the choroid plexus , bind to IGF 2 in the cerebrospinal fluid ( CSF ) and modulate the action of this growth factor . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
The orders of k ( a ) for both IGF 1 and IGF 2 are IGFBP 3 > IGFBP 5 > IGFBP 6 > IGFBP 4 > IGFBP 2 > ++ +IGFBP 1 . ^^^ The order of k ( d ) for IGF 1 is IGFBP 6 > IGFBP 5 > IGFBP 4 > IGFBP 3 > IGFBP 2 > ++ +IGFBP 1 and that for IGF 2 is IGFBP 5 > IGFBP 6 > IGFBP 2 > IGFBP 4 > IGFBP 3 > ++ +IGFBP 1 , respectively . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Insulin like growth factors ( IGF 1 , free IGF 1 and IGF 2 ) and insulin like growth factor binding proteins ( IGFBP 2 , IGFBP 3 , IGFBP 6 , and ALS ) in blood circulation . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
In active MS lesions , the expression of IGF 1 , insulin and IGFBP 1 was detected in hypertrophic astrocytes while that of IGF 2 and IGFBP 2 and 3 was confined to foamy macrophages within lesions and activated microglia in adjacent white matter . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
MEASUREMENTS : IGFBP 1 and insulin were measured in samples drawn every 4 h over the 24 h period while IGF 1 , IGF 2 , IGFBP 2 and IGFBP 3 were determined in samples collected at the end of the study . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
DESIGN , PATIENTS AND MEASUREMENTS : Serum IGF 1 , IGF 2 , IGFBP 1 , IGFBP 2 , IGFBP 3 , osteocalcin ( OST ) , bone specific alkaline phosphatase ( BAP ) , urinary deoxypyridinoline ( DPYD ) and N telopeptide of type 1 collagen ( NTX ) were measured in 31 premenopausal women aged 31 43 and 65 postmenopausal women aged 47 60 : this latter group comprised 30 normal healthy women and 35 osteoporotic women . ^^^ RESULTS : Compared with premenopausal women or normal postmenopausal women , serum IGF 1 and IGFBP 3 levels were significantly lower in osteoporotic postmenopausal women while no significant differences in serum levels of IGF 2 , IGFBP 1 and IGFBP 2 were observed . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
To test this hypothesis , monolayer cultures of chondrocytes were established from the proliferative zone of the growth plate , and were found to release immunoreactive IGF 2 and to express mRNAs encoding IGFBP 2 to 6 . ^^^ IGFBP 2 had a biphasic effect , potentiating IGF 2 action at low concentrations but inhibiting DNA synthesis at equimolar or greater concentrations relative to IGF 2 . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
CSF samples were separated on SDS PAGE and then transferred to nitrocellulose membranes where IGFBPs were detected by Western ligand blot using [ ( 125 ) 1 ] IGF 2 , confirming other reports where we found the presence of IGFBP 2 , 3 , 4 , 5 . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
The high nutritional status of pigs in the early phases of growth diminished the postnatal changes in IGF 1 and IGFBP 2 , but not IGF 2 or IGFBP 3 . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Serum IGFBP 2 levels of CMV IGFBP 2 transgenic mice were about 3 fold ( P < 0 . 05 ) increased , compared with controls , whereas serum levels of IGF 1 and IGF 2 were unaffected by IGFBP 2 overexpression . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
RESULTS : The patients had reduced serum free IGF 1 ( 53 % ) and increased levels of total IGF 2 ( 40 % ) , IGFBP 1 ( 546 % ) , and IGFBP 2 ( 270 % , P < 0 . 05 ) . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Content of IGFII in tumor cells correlated with IGFBP 1 , IGFBP 2 , IGFBP 5 . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Chinese hamster ovary cells stably transfected with the zebrafish IGFBP 2 cDNA secreted a 31 kDa protein , which bound to IGF 1 and IGF 2 with high affinity , but did not bind to Des ( 1 3 ) IGF 1 or insulin . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
In contrast to IGFBP 2 , secretion of IGF 2 and accumulation of IGF 2 mRNA by IEC 6 cells correlated positively with cell number . ^^^ We conclude that expression of IGF 2 and IGFBP 2 are regulated in IEC 6 cells by cellular density , and IGF 2 may act as a survival factor at high cell density . . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Levels of serum total IGF 1 , total IGF 2 , IGFBP 1 , IGFBP 2 and IGFBP 3 were determined experimentally , while those of IGFBP 4 , IGFBP 5 and IGFPB 6 , as well as the 12 affinity constants of association of the two IGFs with the six IGFBPs , were taken from published values . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
We have investigated the effects of restriction of placental growth on foetal adrenal growth and adrenal expression of mRNAs for Insulin like Growth Factor 2 ( IGF 2 ) , the IGF binding protein IGFBP 2 , Steroidogenic Factor 1 ( SF 1 ) and adrenocorticotrophic hormone ( ACTH ) receptor ( ACTH R ) and the steroidogenic cytochrome P 450 enzymes : cholesterol side chain cleavage ( CYP11A1 ) , 17alpha hydroxylase ( CYP 17 ) and 21 hydroxylase ( CYP21A1 ) ; and 3beta hydroxysteroid dehydrogenase / Delta5Delta4 isomerase ( 3betaHSD ) . ^^^ Adrenal IGF 2 mRNA levels were lower ( P < 0 . 05 ) in the PR group , however , adrenal IGFBP 2 mRNA levels were not different between the PR and control groups . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
We have extended the analysis of specimens to include measurements of GHBP , PGH , IGF 1 , IGF 2 , IGF binding protein 1 ( IGFBP 1 ) , IGFBP 2 , and IGFBP 3 and have related these to maternal characteristics , fetal growth , and glycemia . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Subsequently , IGF 2 , IGFBP 2 and IGFBP 3 were determined in the HPLC fractions by specific RIAs . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
In addition , transglutaminase inhibitors , antibodies to thrombospondin , insulin like growth factor 2 in the presence of its binding protein IGFBP 2 , but not IGFBP 1 , suppressed the activation of TGF beta . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
The release of IGFBP 2 and IGFBP 5 were also potentiated without changes to steady state mRNA , and for IGFBP 5 this was due in part to a release from the cell membrane in the presence of IGF 2 . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
We measured basal levels of serum insulin like growth factor 1 ( IGF 1 ) , IGF 2 , IGF binding protein 1 ( IGFBP 1 ) , IGFBP 2 and IGFBP 3 together with 24 h urinary GH excretion . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Studying deficient growth in this hypoplastic infant ( birth weight 1405 g , birth length 36 cm ) with dysmorphic features , the following changes in IGFs and IGFBPs were detected ( microg / l ) : IGF 1 : 26 . 5 vs 48 . 1 in healthy infants ; IGF 2 : 420 vs 728 ; IGFBP 2 : 931 vs 524 ; IGFBP 3 : 800 vs 1070 . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Using RNAase protection analysis ( RPA ) , we examined the gene expression for IGF 1 , IGF 2 , IGF1R , M6P / IGF2R , IGFBP 1 and IGFBP 2 in a series of hepatoblastomas with corresponding normal liver from the same individuals . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Between d 2 and 14 of the estrous cycle , concentrations of progesterone , LH , IGF 2 , and binding activities of IGFBP 3 , IGFBP 2 , and the 27 to 29 kDa IGFBP in plasma did not differ ( P > . 10 ) among breeds . ^^^ These ovarian differences may be due to changes in the pattern of secretion of FSH , insulin , IGF 1 , and GH but not LH , IGF 2 , or IGFBP 2 or 3 . . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
It relates to cell death by differentiation , is followed by accumulation of c fos , c myc , Bax , IGF 2 , IGFBP 2 , IGFBP 5 this indicating their involvement in the regulation of this process . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
There was a positive correlation between IGFBP 4 and IGFBP 2 ( r=0 . 46 , P < 0 . 001 ) ; IGFBP 5 was positively correlated with IGF 1 ( r=0 . 59 , P < 0 . 001 ) , IGF 2 ( r=0 . 42 , P < 0 . 001 ) and IGFBP 3 ( r=0 . 47 , P < 0 . 001 ) and inversely correlated with IGFBP 1 ( r= 0 . 41 , P < 0 . 001 ) . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Fibroblast growth factor 2 inhibits the maturation of pro insulin like growth factor 2 ( Pro IGF 2 ) and the expression of insulin like growth factor binding protein 2 ( IGFBP 2 ) in the human adrenocortical tumor cell line NCI H295R . ^^^ At the same concentrations , FGF 2 also decreased both IGFBP 2 messenger RNA and secreted protein , which might increase IGF 2 bioavailability . ^^^ Altogether , these results indicate that FGF 2 is mitogenic for NCI H295R tumor cells and regulates the expression of both IGF 2 and IGFBP 2 in this tumor model . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Altered IGFBP 2 mRNA levels with reduced IGF 2 mRNA levels in selected tissues may mediate changes in growth and / or differentiation that might become apparent if the length of the UCO study were extended . . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Preoperatively ' big ' IGF 2 and IGFBP 2 levels were raised . ^^^ In conclusion , we have confirmed high levels of big IGF 2 and IGFBP 2 in NICTH , changes which are reversed postoperatively . ^^^ The IGF 2 is derived from the tumour which overexpresses these genes but IGFBP 2 probably arises from extratumour upregulation . . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
On the other hand , IGF 2 and IGFBP 2 are overexpressed in colorectal carcinomas . ^^^ These contrasting backgrounds led us to investigate the relationship between serum IGF 1 , IGF 2 , IGFBP 2 , and IGFBP 3 and the presence of colorectal adenomas , known precursors of colorectal carcinoma , in 345 volunteers attending a screening flexible sigmoidoscopy trial ( entry criteria : healthy , aged 55 64 yr ) . ^^^ Logistic regression adjusting for confounding factors confirmed the significant association between IGF 2 and adenoma occurrence ( P < 0 . 0001 ) and revealed an additional positive association with serum IGFBP 2 ( P < 0 . 0001 ) . ^^^ Additionally , in 31 individuals with adenomas in whom levels were determined pre and postpolypectomy , there was a significant fall in mean IGF 2 ( P < 0 . 001 ) and IGFBP 2 ( P < 0 . 001 ) after adenoma removal , but no difference in IGF 2 and IGFBP 2 concentrations between repeated samples in 20 individuals without adenomas . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
The expression of IGF 2 and IGFBP 2 significantly correlated with pathologic stage , lymph node metastasis , histologic differentiation and serum prostate specific antigen ( PSA ) levels after hormone therapy . ^^^ CONCLUSIONS : In the IGF system , IGF 2 and IGFBP 2 play a role in human prostate cancer progression and their increased expression is a possible candidate for a prognostic indicator in hormone treated prostate cancer patients . . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
We conclude that the serum IGF 2 and IGFBP 2 profiles may provide insights into underlying biological mechanisms , and that serum IGFBP 2 may have an adjunct role in cancer surveillance in patients with colorectal cancer . . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Significant correlations ( p < 0 . 001 ) were seen between total and free ALS concentrations and IGF 1 ( r = 0 . 50 and 0 . 60 , respectively ) , free IGF 1 ( r = 0 . 37 and 0 . 36 ) , IGF 2 ( r = 0 . 37 and 0 . 27 ) , IGFBP 1 ( r = 0 . 48 and 0 . 49 ) , IGFBP 2 ( r = 0 . 44 and 0 . 51 ) and IGFBP 3 ( r = 0 . 67 and 0 . 59 ) at all Tanner stages . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
The expression patterns for 8 of 15 genes have been reported previously in prostate tissues ( TGFbeta 3 , TGFBR 3 , IGFII , IGFBP 2 , VEGF , FGF 7 , ERBB 3 , MYC ) , but those of seven genes are reported here for the first time ( MLH 1 , CYP1B1 , RFC 4 , EPHB 3 , MGST 1 , BTEB 2 , MLP ) . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Both halves of bIGFBP 2 bound IGF 1 and IGF 2 in BIAcore studies , albeit with different affinities ( ( 1 132 ) IGFBP 2 , K ( D ) = 36 . 3 and 51 . 8 nm ; ( 136 279 ) IGFBP 2HIS , K ( D ) = 23 . 8 and 16 . 3 nm , respectively ) . ^^^ Furthermore , des ( 1 3 ) IGF 1 and des ( 1 6 ) IGF 2 exhibited reduced binding affinity to ( 1 279 ) IGFBP 2HIS , ( 1 132 ) IGFBP 2 , and ( 136 279 ) IGFBP 2HIS biosensor surfaces compared with wild type IGF . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Tuberculous granuloma cells are an important source of IGF 2 , IGFBP 2 , 3 , 4 , 5 , 6 playing a role in proliferation and apoptosis of the pulmonary epithelium . . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
METHODS : To evaluate the role of the IGF system in lymphangioleiomyomatosis ( LAM ) , we used immunohistochemical and in situ hybridization techniques to characterize the expression of IGF 1 , IGF 2 , IGF 1R , and IGFBP 2 , 4 , 5 , and 6 in lung tissue from 18 LAM patients . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
In women < or = 50 years of age , measurements of IGF 2 , IGFBP 1 , and IGFBP 2 were also performed . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
The assay was highly specific : no signal was obtained unless both IGF 1 and IGFBP 1 were present and neither IGFBP 2 , 3 , 4 , nor IGF 2 caused any cross reaction . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
The concentrations of IGFBP 2 and IGFBP 4 decreased by 48 + / 6 and 70 + / 13 % , respectively , whereas that of IGFBP 6 increased by 698 + / 20 % with 1 microM tRA . tRA decreased mRNA levels of IGFBP 2 and IGFBP 4 by 20 + / 3 and 50 + / 8 % , respectively , whereas tRA increased IGFBP 6 mRNA by 660 + / 20 % . tRA did not alter levels of IGF 2 mRNA or peptide . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Malignant lymphoblasts of T cell origin more often expressed IGFBP 2 and IGFBP 5 , whereas IGF 2 and IGFBP 3 expression was seen more often in lymphoblasts of B cell origin . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
IGF 2 was more strongly expressed in control tumours , and IGFBP 6 expressing tumours contained less IGFBP 2 than controls . ^^^ In both populations , there was a significant positive correlation between IGF 2 and IGFBP 2 expression . ^^^ In cell culture , IGFBP 6 expressing cells expressed similar amounts of IGFBP 2 , IGF 2 and N myc mRNAs as control cells ; but media conditioned by IGFBP 6 expressing cells contained less intact IGFBP 2 protein , with no increase in its proteolytic fragment . ^^^ In excess , IGFBP 6 would displace IGF 2 from IGFBP 2 whose potentiation of IGF 2 action would cease and whose susceptibility to degradation would be increased . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Insulin like growth factor ( IGF ) 1 , IGF 2 , free IGF 1 , IGF binding protein ( IGFBP ) 1 , IGFBP 2 and IGFBP 3 were measured by radioimmuno / immunoradiometric assays . ^^^ While this study confirms previous observations during treatment with oral oestrogens in substitution doses , the reduction in plasma IGF 2 , free IGF 1 , IGFBP 2 and 3 are all novel findings . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Northern blot analyses if xenografts revealed weaker expression of IGF 2 , type 2 IGF receptor and IGFBP 2 mRNAs in IGFBP 6 expressing cthan in control xenografts . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
We measured IGF 1 , IGF 2 , IGFBP 1 , IGFBP 2 , IGFBP 3 by immunoassays , IGFBP 3 by Western ligand blotting ( WLB ) and finally in vitro IGFBP 3 proteolysis by a ( 125 ) 1 IGFBP 3 degradation assay . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
These results indicate that IGF 1 , IGF 2 , IGFBP 2 , and IGFBP 5 are produced by equine granulosa cells and that insulin , FSH , and estradiol play a role in the regulation of steroidogenesis and the IGF system of equine granulosa cells . . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
RESULTS : Birth weight ( BW ) , birth length ( BL ) , ponderal index , head circumference ( HC ) , and cord serum levels of albumin , prealbumin , retinol binding protein ( RBP ) , total and free IGF 1 , IGF 2 , IGFBP 3 , acid labile subunit ( ALS ) , and leptin were significantly lower , whereas levels of IGFBP 1 , IGFBP 2 , and IL 6 were significantly higher in preterm than in term neonates ( P < 0 . 05 ) . ^^^ CONCLUSIONS : Our results suggest that IGF 1 , IGF 2 , IGFBP 2 , ALS , and leptin play important roles in intrauterine growth . . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Ligand blot analysis of conditioned medium using 125I labeled IGF 2 revealed that t10c12 CLA slightly decreased IGFBP 2 production ; c9t11 CLA had no effect . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Expression of IGF 2 , IGFBP 2 , 5 , and 6 in meningiomas with different brain invasiveness . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
IGFBP 2 to 6 were expressed in the chondrocytes , IGFBP 1 was absent and both IGF 1 and IGF 2 , and the type 1 and type 2 IGF receptors were expressed . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
We found transcriptional upregulation of both IGF 1 and IGF 2 in dystrophic muscle , however the possible beneficial effects of the growth factors appear offset by transcriptional upregulation of inhibitory IGF binding proteins and regulators ( IGFBP 2 , 4 , 6 and 7 ; and PRSS 11 [ IGFBP 5 protease ] ) . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
BMD in total body , distal and UD radius , and femoral neck was positively correlated with serum IGF 1 ( r = 0 . 31 to 0 . 49 ) , IGF 2 ( r = 0 . 32 to 0 . 48 ) , IGFBP 3 ( r = 0 . 37 to 0 . 53 ) , and free androgen index ( FAI ) ( r = 0 . 32 to 0 . 40 ) , and negatively with IGFBP 1 ( r = 0 . 37 to 0 . 41 ) and IGFBP 2 ( r = 0 . 29 to 0 . 41 ) levels . ^^^ Age correlated negatively with serum IGF 1 , IGF 2 , IGFBP 3 , FAI , estradiol / SHBG ratio , and BMD in total body , distal and UD radius , and femoral neck , and positively with IGFBP 1 , IGFBP 2 , and SHBG levels . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Levels of IGFBP 2 , IGFBP 4 , IGF 1 and IGF 2 in media conditioned by 75 day fetal S 5 cultures were not influenced by late DEX . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Only expression of IGF 1 , IGF 2 and IGFBP 2 could be detected in the growth plates of 7 week old normal mice . ^^^ DXM treatment of normal mice induced a significant 2 . 4 fold increase in the number of cells expressing IGF 1 mRNA , whereas IGF 2 and IGFBP 2 mRNA levels were not affected . ^^^ In hIGF 2 transgenic mice , IGF 1 mRNA levels were significantly increased , while endogenous IGF 2 and IGFBP 2 mRNAs were unaffected , compared to normal animals . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Statistical analysis showed a distinct expression profile for the group of synovial sarcomas as compared to the other soft tissue sarcomas , which included variably high expression of ERBB 2 , IGFBP 2 , and IGF 2 in the synovial sarcomas . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Serum T and F IGF 1 and IGF 2 were determined using noncompetitive time resolved monoclonal immunofluorometric assays , IGFBP 1 was determined by an in house RIA , IGFBP 2 by a novel in house time resolved immunofluorometric assay , whereas IGFBP 3 by an immunoradiometric assay . ^^^ Specifically , mean T IGF 1 for patients group was 131 ( 61 ) , F IGF 1 was 0 . 47 ( 0 . 16 ) , T IGF 2 was 1056 ( 300 ) , F IGF 2 was 1 . 45 ( 0 . 54 ) , IGFBP 1 was 33 ( 14 ) , IGFBP 2 was 848 ( 377 ) , and finally IGFBP 3 was 3953 ( 1422 ) . ^^^ For controls , mean T IGF 1 was 146 ( 51 ) , F IGF 1 was 0 . 85 ( 0 . 43 ) , T IGF 2 was 939 ( 197 ) , F IGF 2 was 1 . 53 ( 0 . 53 ) , IGFBP 1 was 44 ( 24 ) , IGFBP 2 was 764 ( 316 ) and finally IGFBP 3 was 3721 ( 1017 ) . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
In normal testes a clear expression of IGF 1 , IGF 2 , IGF IR , IGFBP 2 , IGFBP 4 and IGFBP 5 was found . ^^^ The expression of AR , IGF 2 and IGFBP 2 , IGFBP 3 , IGFBP 5 , and 5alpha reductase type 2 did not differ among the different types of tumors . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
To this end , we evaluated the behavior not only of IGF 1 but also of IGF 2 , IGF binding protein ( IGFBP ) 3 , and acid labile subunit , the subunits that constitute the main IGF complex in circulation ( 150 kDa complex ) , as well as of IGFBP 1 and IGFBP 2 , which are negatively regulated by GH and , like IGFBP 3 , able to influence the bioavailability of the IGFs . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
With in situ hybridization , insulin like growth factor 2 ( IGF 2 ) mRNA and insulin like growth factor binding protein 2 ( IGFBP 2 ) , 3 and 6 were all detected in the placentome capsule ; IGF 2 mRNA was also found in the mesoderm of the fetal villi and IGFBP 3 and IGFBP 6 were present in the caruncular stroma of the maternal villi . ^^^ Ewes of moderate condition , which had the smallest placentae , had the greatest placental expression of IGF 2 , IGFBP 2 and IGFBP 3 . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
The functional classification of the 33 genes identified was related to several kinds of biological pathways , regulating the cell cycle ( PCNA , CDC7L1 , CCND 3 , YWHA 1 , PKMYT 1 ) , DNA replication and repair ( RFC 4 , RECQ 2 , PCNA , NAP1L1 ) , cell growth ( IGF 2 , IGFBP 2 , PRSS 11 ) , hormonal signals ( AR , SRD5A1 , NR1I3 ) , and cellular metabolism ( E 2 EPF , WWP 1 , CYP2C9 , CYP2E1 , CYP2A6 , CYP2A7 , CYP2A13 , CYP4F2 , CYP3A4 , DDT ) . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
We report that these genes fall into two distinct groups with respect to expression pattern , with IGFBP 2 displaying broad overlap of mRNA expression with IGFR and IGF 1 during early development , whereas the expression profile of IGFBP 5 most closely resembled that of IGF 2 . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
In the growth plates , both IGF 1 and IGF 2 , as well as IGFBP 2 mRNAs were detected , mainly in the proliferative and prehypertrophic zones . ^^^ DXM treatment significantly decreased the number of chondrocytes expressing IGF 1 , whereas the number of chondrocytes expressing IGF 2 and IGFBP 2 were not affected . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
CONCLUSION : In contrast to C GF , the availability of IGF 2 in CAIS GF is apparently decreased by two facts : by the decreased expression and by increased expression of IGFBP 2 , 3 and 5 . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
The significantly reduced levels of IGF 1 ( p < 0 . 001 ) , IGF 2 ( p=0 . 017 ) and IGFBP 3 and the increased presence of IGFBP 2 were found in patients with echinococcosis . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Our aim was to evaluate the role of IGFBP 2 levels together with insulin like growth factor ( IGF ) 1 , IGF 2 and IGFBP 3 in the diagnostic work up of patients with hepatocellular carcinoma ( HCC ) . ^^^ METHODS : In 50 ( 39 males , 11 females ) histologically confirmed and TNM graded patients with HCC who had not received adjuvant chemotherapy , the basal serum levels of IGF 1 , IGF 2 , IGFBP 3 , IGFBP 2 and alpha fetoprotein ( AFP ) were measured . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
The transcripts of IGF 1 , IGF 2 , IGF receptor ( IGF R ) , two IGF binding proteins ( IGFBP 2 and IGFBP 5 ) , GH receptor ( GH R ) and insulin receptor ( 1 R ) were measured by RT PCR at 4 , 8 , 12 and 16 weeks of age in the ovaries of ad libitum fed and feed restricted hens . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Ligand blot analysis of conditioned medium using ( 125 ) 1 IGF 2 revealed that the production of IGFBP 2 and IGFBP 4 was also decreased by t10c12 CLA , whereas c9t11 CLA had no effect . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Determination of IGF 1 , IGF 2 , IGFBP 2 , and IGFBP 3 levels in serum and plasma : comparisons using the Bland Altman method . ^^^ Blood was obtained from 47 healthy volunteers ( age 21 72 years ) in serum , heparin plasma and EDTA plasma , and IGF 1 , IGF 2 , IGFBP 2 , and IGFBP 3 measured , and results compared . ^^^ Mean values for IGF 1 , IGF 2 , IGFBP 2 and IGFBP 3 determined in all three media were generally comparable ; correlations were generally strong and significant ( P < 0 . 001 ) . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
We have assessed 46 adult STS specimens of low , intermediate and high pathological grade of malignancy for the immunohistochemical expression of IGFBP 2 , IGF 1 , IGF 2 , IGF 1 receptor alpha and beta ( IGF1Ralpha / beta ) . ^^^ Using both methods , significant differences in expression of IGFBP 2 among each of the three grades , expression of IGF 2 between intermediate and high grade , and expression of IGF1Rbeta between low intermediate and low high grade were observed ( Dunnett test , P < 0 . 05 ) . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Assays of IGF 1 , IGF 2 , IGFBP 2 and IGFBP 3 were performed on cases and 2 controls matched on age , recruitment center and calendar time . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
In colostrum fed calves , DEXA decreased ( P < 0 . 05 ) mRNA levels of IGF 1 ( esophagus , fundus , duodenum , and ileum ) , IGF 2 ( fundus ) , IGFBP 2 ( fundus ) , IGFBP 3 ( fundus ) , IGF1R ( esophagus , ileum , and colon ) , IGF2R ( fundus ) , GHR ( fundus ) , and InsR ( esophagus , fundus ) , but in formula fed calves DEXA increased mRNA levels of IGF 1 ( esophagus , rumen , jejunum , and colon ) . ^^^ Furthermore , DEXA increased ( P < 0 . 05 ) mRNA levels of IGF 2 ( pylorus ) , IGFBP 3 ( duodenum ) , IGF2R ( pylorus ) , and GHR ( ileum ) , but decreased mRNA levels of IGFBP 2 ( ileum ) , and IGF1R ( fundus ) . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
IGF 1 , IGF 2 , IGFBP 1 , IGFBP 2 , IGFBP 3 and IGFBP 6 were examined by specific assays . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Assays of IGF 1 , IGF 2 , IGFBP 2 , IGFBP 3 , and free and total PSA were performed . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Overexpression of human IGF 2 mRNA in the brain of transgenic mice modulates IGFBP 2 gene expression in the medulla oblongata . ^^^ To clarify the localization and influence of the hIGF 2 transgene on different components of the GH IGF axis in the brain , we studied the expression pattern of the hIGF 2 transgene , endogenous IGF 1 and IGF 2 , and IGFBP 2 , 3 and 5 in the brain of prepubertal 4 week old mice , using nonradioactive in situ hybridization . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
We determined serum levels of insulin like growth factors ( IGF 1 , IGF 2 ) and binding proteins ( IGFBP 2 and IGFBP 3 ) at diagnosis ( 1 ) , during ( 2 ) and after therapy ( 3 ) in 28 children treated for ALL . ^^^ RESULTS : 1 ) Serum absolute levels of IGF 1 , IGF 2 , IGFBP 3 rose and IGFBP 2 decreased during analysis . 2 ) Mean values of IGF 1 SDS were similar at diagnosis , during and after treatment ( 1 . 78+ / 0 . 9 vs . 1 . 86+ / 1 . 36 vs . 1 . 8+ / 0 . 83 ) . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
METHODS : IGF 1 , IGF 2 , IGFBP 2 , IGFBP 3 , IGFBP 4 and IGFBP 6 levels were determined by RIAs . ^^^ RESULTS : NSD 1 ( + / ) patients showed significantly altered levels of IGF 1 ( mean 1 . 2 SDS ) , IGF 2 ( 1 . 2 ) , IGFBP 3 ( 1 . 7 ) , IGFBP 4 ( 0 . 4 ) , IGFBP 2 ( +0 . 8 ) and IGFBP 6 ( +1 . 5 ) . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Endometrial mRNA for IGF 1 , IGF 2 , IGFBP 2 , and IGFBP 3 increased in bST C , but not in bST P cows . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Per 275 units higher levels of IGF 2 , an IRR ( 95 % CI ) of 1 . 35 ( 1 . 10 1 . 66 ) was observed for ER positive tumors , whereas IGFBP 2 was not associated with breast cancer risk . ^^^ There was no association between IGF 1 , IGF 2 , IGFBP 2 , or IGFBP 3 and risk of ER negative breast cancer . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
All four hormones increased gene and / or protein expression of PSA , IGF IR , IGF 1 , and IGFBP 2 and decreased that of AR , ERbeta , IGF 2 , and IGFBP 3 . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
We studied by real time reverse transcription PCR , whether there are differences in the abundance of mRNA coding for IGF 1 , IGF 2 , IGFBP 2 , IGFBP 3 , IGF 1R , IGF 2R , GHR , and InsR in compartmentalized layers ( fractions ) of jejunum and ileum of 5 d old calves fed colostrum . ^^^ In ileum , mRNA levels , expressed relative to housekeeping genes , differed ( P < 0 . 05 ) between fractions for IGF 1 ( LP > villi , crypts ) , IGF 2 , and IGFBP 3 ( villi > crypts , LP ) , GHR and InsR ( crypts > LP ) , IGFBP 2 ( crypts > villi , LP ) , and total RNA levels were greater ( P < 0 . 05 ) in LP and crypt than in villus fractions . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
IGFBP 2 , 3 , 4 and 5 gene expression followed a similar pattern to IGF 2 and the IGF receptors , whereby expression decreased with increasing follicle size . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Total and free IGF 1 , IGF 2 , IGFBP 3 , and IGFBP 3 protease were similar between groups ( all P > . 5 ) , whereas , in LIPO , IGFBP 1 and IGFBP 2 were reduced ( 36 % , P < . 05 and 50 % , P < . 01 ) . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Neither 100 ng / ml of IGF 1 nor IGF 2 had an effect ( P > 0 . 10 ) on IGFBP 2 , 3 , 4 , or 5 mRNA levels in small follicle ( 1 5 mm ; Experiment 1 ) granulosa cells . ^^^ In large follicle ( > 7 . 9 mm ; Experiment 2 ) granulosa cells , 100 ng / ml of IGF 1 increased ( P < 0 . 05 ) IGFBP 2 mRNA levels above controls and 3 ng / ml of IGF 1 ; 100 ng / ml of IGF 1 also decreased ( P < 0 . 10 ) IGFBP 5 mRNA levels compared to 3 ng / ml of IGF 1 or FSH or 100 ng / ml leptin , while 100 ng / ml of IGF 2 had no effect ( P > 0 . 10 ) on IGFBP 2 , 3 , 4 , and 5 mRNA levels ( Experiment 2 ) . ^^^ In theca cells , IGF 2 decreased ( P < 0 . 05 ) IGFBP 2 mRNA levels , but had no effect on IGFBP 3 or 4 mRNA expression ( Exp . 3 ) ; IGF 1 did not affect ( P > 0 . 10 ) thecal IGFBP 2 , 3 or 4 mRNA levels . ^^^ Ligand blotting revealed that both IGF 1 and 2 increased IGFBP 2 and 5 ( protein ) and had no effect on IGFBP 3 ( protein ) , whereas IGF 1 ( but not IGF 2 ) increased IGFBP 4 ( protein ) , suggesting IGFBP 2 , 4 , and 5 are post transcriptionally regulated . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Free IGF 1 , total IGF 2 , IGFBP 3 , and GH binding protein were lower , whereas IGFBP 1 , IGFBP 1 bound IGF 1 , and IGFBP 2 were elevated compared with control values . ^^^ Patients with detectable C peptide ( > or =100 pmol / liter ) had higher levels of total IGF 1 , free IGF 1 , and total IGF 2 and lower levels of IGFBP 1 and IGFBP 2 than those with an undetectable C peptide level despite having identical average HbA1c . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Furthermore , an IGFBP 3 protease cleaving also IGFBP 2 but not IGFBP 4 was co purified from the IGF 2 column . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
The IGF 2 expression was not similar to IGFBP 2 during postnatal growth . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Serum levels of IGF 1 , IGF 2 , IGF binding protein ( IGFBP ) 1 , IGFBP 2 , and IGFBP 3 were measured in 162 children with acute lymphoblastic leukemia treated by the Berlin Frankfurt Munster Study Group . ^^^ At diagnosis we found elevated IGFBP 2 , low IGFBP 3 , low IGF 1 , and low normal IGF 2 , but normal IGFBP 1 levels . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Secretion of IGF 1 , IGF 2 , and IGFBP 2 by PBMCs from healthy adult donors was determined by radioimmunoassays ( RIAs ) . ^^^ The PBMC proliferative response after stimulation with anti CD 3 mAb and exposure to increasing concentrations of IGF 1 , IGF 2 , IGFBP 2 , and anti IGFBP 2 were determined by bromodeoxyuridine enzyme linked immunosorbent assay . ^^^ The stimulatory activity of IGFBP 2 ( 1 10 ng / ml ) on anti CD 3 mAb activated PBMCs was similar to that of IGF 1 and IGF 2 ( 1 100 ng / ml ) , with the mean increase in PBMC proliferative response ranging between 150 % and 160 % for IGFBP 2 ( p = 0 . 03 ) , 150 % and 170 % for IGF 1 ( p < 0 . 01 ) , 133 % 161 % for IGF 2 ( p < 0 . 01 ) , and 157 % and 175 % for IGF 1 + IGF 2 ( p < 0 . 01 ) . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
The most abundant fragment IGFBP 2 ( 167 279 ) showed 10 % of IGF 2 binding compared to recombinant human ( rh ) IGFBP 2 . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
For IGF 2 , both IGF receptors and IGFBP 2 , 3 , 4 , 5 , and 6 , gene expression decreased as follicles increased in diameter ( P < 0 . 01 ) . ^^^ IGF 2 , type 1 IGF R and IGFBP 2 , 3 , 4 , and 6 mRNA expression significantly decreased as follicles progressed from healthy to atretic status ( P < 0 . 01 ) , whereas gene expression for type 2 IGF R and IGFBP 5 was greater in atretic follicles ( P < 0 . 01 ) . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Measures at baseline , 6 and 12 months included body weight , height , body fat , lean mass , body fat % , and waist circumference , as well as fasting glucose , insulin , insulin resistance , insulin like growth factor 1 ( IGF 1 ) , IGF 2 , and IGF binding protein 1 , IGFBP 2 , and IGFBP 3 . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
There were no differences in plasma concentrations of total IGF 2 , free IGF 1 and 2 , IGFBP 3 , GHBP and ghrelin , whereas a small difference was found for IGFBP 2 ( 302+ / 97 vs . 263+ / 66 microg / L ; LNP vs . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
There was no correlation of plasma IGFBP 4 level with age , sex , immunophenotype , or ALL risk group , and there was no correlation of IGFBP 4 level with plasma IGF 1 , IGF 2 , IGFBP 1 , IGFBP 2 , and IGFBP 3 levels . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
The endometrium contained less IGF 2 mRNA but more IGFBP 2 and 3 mRNA than the placental chorion . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
We assessed the association of prediagnostic plasma levels of IGF 1 , IGF 2 , IGFBP 2 , and IGFBP 3 and subsequent occurrence of prostate cancer in a case control study nested in the SU . ^^^ Frozen baseline plasma samples were used to measure IGF 1 , IGF 2 , IGFBP 2 , and IGFBP 3 . ^^^ After controlling for the intervention group in the trial and the other IGF axis variables , the odds ratios and 95 % confidence interval ( 95 % CI ) comparing the upper quartile to the baseline quartile were 1 . 83 ( 95 % CI , 0 . 85 3 . 95 ) , 1 . 05 ( 95 % CI , 0 . 35 3 . 18 ) , 0 . 79 ( 95 % CI , 0 . 39 1 . 58 ) , and 0 . 42 ( 95 % CI , 0 . 12 1 . 52 ) for IGF 1 , IGF 2 , IGFBP 2 , and IGFBP 3 , respectively . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Combined treatment caused a higher increase in IGFBP 1 and larger suppression of total and free IGF 1 , IGF 2 , and IGFBP 3 ( P < 0 . 01 for all ) , but less suppression of IGFBP 2 ( P < 0 . 05 ) compared with tamoxifen monotherapy . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Serum IGF 2 , IGFBP 2 , and IGFBP 3 levels did not change . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
In the present study , the in vivo effects of estradiol 17beta ( E 2 ) and growth hormone ( GH ) exposure on IGF 1 , IGF 2 , IGF1R , and IGFBP 2 gene expression in sea bream ovary were monitored by RT PCR during prereproductive and reproductive periods . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Serum IL 1beta , IL 6 , TNF alpha , IGF 1 , IGF 2 , IGFBP 2 , IGFBP 3 , TSH , fT 3 and fT 4 were measured using standard commercial kits . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Serum IGF 1 , IGF 2 , IGFBP 2 , IGFBP 3 , IL 1beta , IL 6 , TNFalpha , insulin and C peptide were measured . ^^^ Serum concentrations of IGF 1 and IGF 2 were significantly lower and insulin and C peptide levels significantly increased in CF compared with healthy controls whereas IGFBP 3 serum concentrations were similar , with comparable IGF I / IGFBP 3 and decreased IGF I / IGFBP 2 and IGF II / IGFBP 2 molar ratios . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Role of IGFBP 2 , IGF 1 and IGF 2 in regulating long bone growth . ^^^ IGF 1 and IGFBP 2 are co expressed in dynamic fashions in the developing long bones of the chick wing , and we have found that IGF 2 is present in the cartilage model and surrounding perichondrium , proliferative and hypertrophic chondrocytes and developing periosteum . ^^^ To gain insight into endogenous roles of IGF 1 , IGF 2 and IGFBP 2 in long bone development , we have overexpressed IGFBP 2 in the developing skeletal elements of the embryonic chick wing in vivo , using an RCAS retroviral vector . ^^^ We also have found that IGFBP 2 blocks the ability of IGF 1 and IGF 2 to promote proliferation and matrix synthesis by wing chondrocytes in vitro . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
In contrast , during the study period total and free IGF 2 decreased ( P < 0 . 05 ) , whereas total IGF 1 , IGFBP 1 and IGFBP 2 increased ( P < 0 . 001 ) . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
In a rat osteoblast cell culture that we studied , IGF 2 and IGFBP 2 were the most abundant peptides of the IGF system released in cell medium , IGFBP 5 was abundantly expressed but bound to cell surface and cell matrix and IGF 1 and IGFBP 3 were found at very low concentrations . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
The effects of progesterone withdrawal were not associated with changes in placental expression of either IGF 2 or IGFBP 2 , both important players in growth factor regulation of placental growth . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Relationship between insulin like growth factors ( IGF 1 and IGF 2 ) , IGF binding proteins ( IGFBP 3 , IGFBP 2 ) , leptin and anthropometric parameters ( height , body mass index ) during antileukaemic treatment in children . ^^^ PURPOSE : The aim of the study was to estimate the anthropometric parameters and their relationship to serum levels of IGF 1 , IGF 2 , IGFBP 3 , IGFBP 2 and leptin before and during intensive antineoplastic treatment for acute lymphoblastic leukaemia in children . ^^^ MATERIAL AND METHODS : In 46 children in median age 6 . 6 years ( range from 1 . 6 to 16 ) we evaluated at the time of diagnosis , after protocol 1 and after intensive treatment , height , body mass index ( BMI ) and IGF 1 , IGF 2 , IGFBP 3 , IGFBP 2 and leptin . ^^^ IGF 1 SDS was low and similar at each point , IGF 2 SDS and IGFBP 3 SDS values augmented progressively and IGFBP 2 SDS was significantly elevated before treatment and lowered ( but not normalized ) during the therapy . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
We have investigated insulin like growth factor ( IGF ) 1 and IGF 2 binding to bovine insulin like growth factor binding protein 2 ( bIGFBP 2 ) using chemical modification to locate sites on the IGF involved in the binding interaction . bIGFBP 2 was incubated with either recombinant human ( hIGF 1 ) or purified ovine ( oIGF 2 ) to form a mixture of bound and free IGF . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
RESULTS : In fully adjusted models ( controlling for age , sex , socioeconomic factors , lifestyle , and body mass index ) , childhood height and its components were not associated with adult circulating IGF 1 , IGF 2 , or IGFBP 2 levels . ^^^ Height in adulthood was not associated with IGF 1 , IGF 2 , or IGFBP 3 and was inversely associated with IGFBP 2 ( P = 0 . 05 ) after additionally controlling for childhood height . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
In contrast , IGF 2 levels were high in CL but did not vary throughout the oestrous cycle , while IGFBP 2 , 3 , 4 and 6 mRNA levels were highest throughout the luteal phase but lower in regressing CL ( P < 0 . 05 ) . ^^^ IGF 2 , type 1 IGF R and IGFBP 2 , 3 , 4 and 6 mRNA levels remained unaffected by GnRH antagonist treatment . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
In 27 children with AML ( mean age 13 . 6+ / 5 . 3 years ; patients in remission n=15 with relapse n=12 ) serum parameters of IGFBP 2 , IGFBP 3 , IGF 1 and IGF 2 were analyzed up to 18 months after HSCT by RIA . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
In the present study , circulating IGF 1 , IGF 2 and their binding proteins ( IGFBP 3 , IGFBP 2 and IGFBP 1 ) were determined in 92 adult patients with gastrointestinal inflammation ( Crohn ' s disease , colitis ulcerosa , gastritis , duodenitis errosiva , gastrointestinal candidiasis , and rotaviral and adenoviral enteritis ) . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
In fast muscle , there was a decrease in IGF 2 ( P < 0 . 01 ) on embryonic day ( ED ) 16 and an increase in IGFBP 2 ( P < 0 . 01 ) and IGFBP 4 ( P < 0 . 05 ) and in IGFBP 5 ( P < 0 . 05 ) expression on ED 18 in the stimulated group compared with the control group . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
A bound dipeptide yields information on the substrate specificity of ulilysin , which specifically hydrolyzes IGFBP 2 to 6 , insulin , and extracellular matrix proteins but not IGFBP 1 or IGF 2 . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
We report on a 10 yr old Caucasian girl affected by Costello syndrome with fasting hypoglycemia and short stature , associated low circulating levels of acid labile subunit ( ALS ) , relatively low levels of IGF 1 and IGFBP 3 , and normal IGF 2 , mostly circulating in a binary complex with IGFBP 2 and 6 instead of in a 150 kDa ternary complex . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
These results suggest that prolactin influences hepatocyte proliferation in vitro by inhibiting IGFBP 1 , IGFBP 2 , and IGF 2 levels , which may coincide with the decline of IGF 2 observed in rodents during late gestation in vivo . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
METHODS : Fasting IGFBP 2 , IGFBP 1 , IGFBP 3 , IGF 1 , IGF 2 , insulin , C peptide , glucose , lipids , NEFAs , and HbA1c were measured in a cohort of 163 patients with type 2 diabetes . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
Insulin like growth factor binding protein 2 and insulin like growth factor 2 messenger RNAs are co localized in the choroid plexus and leptomeninges from the time of birth onward without diminution . ^^^
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
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Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
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Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
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Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
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Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
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Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
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Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
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Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
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Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
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Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
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Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
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Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
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Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
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Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
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Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
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Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
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Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
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Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
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Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
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Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
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Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
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Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
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Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
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Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
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Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
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Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18065 and P01344	Pubmed	SVM Score :0.0
NA