| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.57434769 |
| We also discuss the interaction modes of insulin like growth factor 2 with the insulin receptor and the type 1 insulin like growth factor receptor . . 0.57434769^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| It interacts with three different receptors : the IGF 1 , the IGF 2 , and the insulin receptor . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| Also , mannose 6 phosphate did not affect labeled IGF 2 binding to the insulin receptor . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| The genes for IGF 1 and IGF 2 , IGFBP 2 , insulin receptor , and type 1 and 2 IGF receptors were detected . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| IGF 2 is also capable of binding to the insulin receptor . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| IGF 2 peptide binds weakly to the insulin receptor and exerts insulin like effects on the blood glucose level . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| A significant increase in the expression of IGF 1 , IGF 2 , the IGF 1 receptor , and the insulin receptor also was noted . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| Insulin receptor activation by IGF 2 in breast cancers : evidence for a new autocrine / paracrine mechanism . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| Similarly , IGF 2 appears to act through a heterologous autocrine mechanism via the IGF 1 or the insulin receptor . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| A novel autocrine loop involving IGF 2 and the insulin receptor isoform A stimulates growth of thyroid cancer . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| IGF 2 binding to insulin receptor isoform A induces a partially different gene expression profile from insulin binding . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| Differential gene expression induced by insulin and insulin like growth factor 2 through the insulin receptor isoform A . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| The actions of the IGFs are mediated through their activation of specific cell surface receptors , primarily the IGF 1 receptor , although some effects may be mediated through the IGF 2 receptor and the insulin receptor . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| We have investigated the expression of IGF 2 as well as IGF 2 , IGF 1 and insulin receptor mRNAs in non parenchymal liver cell preparations in rats of various ages . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| Two different IGF II / M 6 P receptor antibodies and an insulin receptor antibody failed to significantly block IGF 2 actions . ^^^ Since beta gal decreases the binding affinity of the IGF II / M 6 P receptor for IGF 2 and does not bind to the IGF 1 or insulin receptor , these data suggest the possibility that IGF 2 mitogenic action is mediated through the IGF II / M 6 P receptor . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| Our results that the hexapeptide stimulates [ 3H ] thymidine incorporation and up regulates IGF 2 and casiragua insulin binding sites may be connected to one or several of the following findings : the hystricomorph insulins of which the casiragua insulin is a member stimulate DNA synthesis to a greater extent than other insulins ; the insulin and type 1 IGF receptor binding regions are localized predominantly in the C terminal region of the insulin B chain ; and the `` cooperative ' ' site regulating the affinity of the insulin receptor is also located in the C terminal region of the insulin B chain . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| These results indicate that ( 1 ) the high affinity of binding of insulin to its receptor can occur in the absence of insulin receptor specific residues encoded by exon 3 , the cysteine rich region ; ( 2 ) the cysteine rich region of the IGF 1 receptor can confer high affinity binding to both IGF 1 and IGF 2 ; and 3 ) the IRR is unlikely to be a receptor for either IGF 1 , IGF 2 , or relaxin . . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| In the binding study of those mutant rIGF IIs , IGF 2 was observed to have an unexpectedly high affinity for pure human placental insulin receptor preparations . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| Transcripts for insulin receptors , IGF 1 receptors , and IGF 2 receptors were detected in RNA samples from day 7 . 5 to day 9 . 5 mouse embryos and in F 9 cells , although the level of insulin receptor mRNA in F 9 cells was very low . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| The maximal response obtained with IGF 2 was 4 to 7 fold higher than that with insulin , suggesting that it acts through the insulin receptor as well . ^^^ Tyrosine that IGF 2 acts through the insulin receptor as well . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| It thus appears that IGF 1 and IGF 2 are mitogens for normal and transformed human keratinocytes and that their actions are primarily mediated through the type 1 IGF receptor , whereas insulin is a mitogen through both the IGF 1 receptor and the insulin receptor . . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| Insulin like growth factor 2 ( IGF 2 ) is able to interact with three different receptors : the type 1 and type 2 IGF receptors , and the insulin receptor , although with a lower affinity . ^^^ Receptor binding experiments demonstrate a high affinity for the type 2 IGF receptor , analogous to synthetic ( syn ) and recombinant ( rec ) IGF 2 , but no affinity for the type 1 IGF and the insulin receptor at concentrations up to 50 and 200 ng / ml , respectively . ^^^ The lack of affinity for these two receptors is confirmed by biological studies which demonstrated that this analog , in contrast with synIGF 2 , did not stimulate [ 3H ] thymidine incorporation in Balb / c 3T3 cells . [ Leu 27 ] IGF 2 opens new ways to identify which actions of IGF 2 are mediated via the type 2 receptor and which are due to cross reactivity with the type 1 IGF or the insulin receptor . . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| In both species , IGF 2 has been reported to stimulate glucose transport by interacting with the insulin receptor . ^^^ The possibility of IGF 2 stimulating glucose transport by interacting predominantly with the insulin receptor is suggested by the following : 1 ) the concentration of IGF 2 that inhibits half of insulin binding is only 20 times more than that of insulin ; 2 ) the lack of an additive effect of IGF 2 and insulin for maximal stimulation of glucose transport ; 3 ) the ability of monoclonal insulin receptor antibodies to decrease glucose transport stimulated by submaximal concentrations of both IGF 2 and insulin ; and 4 ) the ability of IGF 2 to stimulate insulin receptor autophosphorylation albeit at a reduced potency when compared with insulin . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| IGF 1 and IGF 2 do not cross react with the insulin receptor to which insulin binds with an apparent Kd approximately 1 nM , and stimulates its tyrosine kinase activity with ED 50 approximately 3 nM . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| Genotypes for insulin hypervariable region ( HVR ) , insulin like growth factor 2 ( IGF 2 ) , insulin receptor ( INSR ) , and glucose transporter ( GLUT 1 ) RFLPs were studied in 96 GDM and 164 control subjects , matched to GDM for race , age , and gravidity . ^^^ In Caucasians , an additional significant risk factor was determined by an INSR allele 1 IGF 2 allele 2 interaction ( P = 0 . 018 ) . ^^^ In Caucasian women , INSR and IGF 2 alleles interact to confer additional risk for GDM . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| An MAb that specifically binds to the IGF 1 receptor ( but not to the insulin receptor ) mediates a dose dependent inhibition of cell growth in basal media as well as IGF 1 , IGF 2 , or insulin supplemented media . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| Second , antibody to the insulin receptor , which blocks insulin , but not IGF 2 , binding to HTC cells , causes a rightward shift in the concentration dependence for insulin induction of desensitization , but does not significantly change the concentration dependence for IGF 2 . ^^^ These results indicate that IGF 2 induced desensitization to IGF 2 is not mediated by the insulin receptor , but presumably by an IGF receptor . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| However , MSA and IGF 2 stimulate these metabolic responses only at high concentrations , indicating that these peptides are acting through the insulin receptor . ^^^ We conclude that in H 35 cells , the insulin receptor , rather than the type 2 IGF receptor , mediates the metabolic responses stimulated by MSA and IGF 2 as well as the MSA induced desensitization to insulin and MSA action . . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| Competitive binding and chemical cross linking experiments showed that IgG 3637 blocked binding of 125I IGF 2 to the rat type 2 IGF receptor , but did not block binding of 125I IGF 1 to the type 1 IGF receptor , nor did IgG 3637 block binding of 125I insulin to the insulin receptor . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| Covalent cross linking of IGF 1 to its receptor revealed a mol wt of 145 , 000 , similar to that of insulin receptor , except that IGF 1 was 100 fold more potent than insulin in competing with [ 125I ] IGF 1 for binding . [ 125I ] IGF 2 in all cells was cross linked to receptor with mol wt of 260 , 000 and 230 , 000 under reduced and nonreduced conditions , respectively . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| Additionally , a band was observed at an apparent mol wt greater than 300 , 000 unreduced and 125 , 000 upon reduction , probably representing IGF 2 binding to the IGF 1 or insulin receptor . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| Insulin does not compete for IGF 2 binding sites and proinsulin competes only weakly , suggesting that this is a type 2 IGF receptor and not an insulin receptor . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| Specific binding of 125I IGF 1 to basolateral membranes was observed that was half maximal at between 10 ( 9 ) and 10 ( 8 ) M IGF 1 . 125I IGF 1 was affinity cross linked to a 135 , 000 Mr protein in basolateral membranes that was distinct from the alpha subunit of the insulin receptor and from the IGF 2 receptor . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| For this receptor preparation , free of type 2 IGF receptor and essentially free of insulin receptor , dissociation constants of Kd = 0 . 05 nM for IGF 1 and of Kd = 0 . 2 nM for IGF 2 ( linear Scatchard plots ) were determined . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| In these studies , the increase in IGF 2 binding correlated significantly with the activation of the insulin receptor tyrosine kinase ( r = 0 . 927 , p less than 0 . 001 ) . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| The potencies of chicken and guinea pig insulins are appropriate for an insulin receptor in the control ( WTB ) and both mutant cell lines , whereas rat IGF 2 is 3 times more potent than expected in the Lec 1 cells and human IGF 1 is less potent than anticipated . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| The actions of insulin , vanadate ( 5 ) and hydrogen peroxide ( H2O2 ) on IGF 2 binding and insulin receptor tyrosine kinase activity were studied in rat adipocytes . ^^^ Incubating adipocytes with a combination of 5 plus H2O2 resulted in a potent synergistic effect on both the increase in IGF 2 binding and the activation of the insulin receptor kinase . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| The redistributions of glucose transporters and IGF 2 receptors are half maximal at approximately 0 . 1 nM insulin , whereas insulin receptor redistribution correlates with receptor occupancy ( 1 / 2max approximately equal to 3 nM ) . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| A mouse monoclonal antibody to the human insulin receptor that inhibits insulin binding and blocks insulin action inhibited 75 % of 125I insulin binding , but inhibited neither 125I IGF 1 nor 125I IGF 2 binding . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| Affinity cross linking of 125I IGF 2 to the Mr = 250 , 000 type 2 IGF receptor structure in rat liver membranes was blocked by the anti receptor Ig , while no effect on affinity labeling of insulin receptor with 125I insulin or IGF 1 receptor with 125I IGF 1 or 125I IGF 2 was observed . ^^^ Rather , at least in H 35 cells , the insulin receptor appears to mediate the effects of IGF 2 on cell growth . ^^^ Consistent with this interpretation , anti insulin receptor Ig but not anti IGF 2 receptor Ig mimicked the ability of growth factors to stimulate DNA synthesis in H 35 cells . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| Fab fragment prepared from anti insulin receptor IgG completely blocked the stimulation of [ 35S ] sulfate incorporation into macromolecules by insulin while only partially inhibiting the biologic response to insulin like growth factors , MSA , IGF 1 , and IGF 2 . ^^^ Similarly , the anti insulin receptor IgG only partially inhibited the binding of 125I IGF 1 and 125I IGF 2 while completely blocking the binding of 125I insulin . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| Similarly , IGF 1 and IGF 2 competed for occupancy of the IM 9 insulin receptor , with 50 % displacement of 125I insulin occurring at peptide concentrations of 3 . 5 10 10 ( 9 ) M ( insulin ) , 3 . 5 10 10 ( 8 ) M ( IGF 2 ) , and 3 10 10 ( 7 ) M ( IGF 1 ) . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| A monoclonal antibody to the human insulin receptor was tested for its ability to inhibit the binding of 125I insulin like growth factor 1 ( IGF 1 ) and 125I insulin like growth factor 2 ( IGF 2 ) to their receptors in human placenta membranes and cultured human IM 9 lymphocytes . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| The effects of IGF 1 and IGF 2 apparently occur as a result of binding to the type 1 IGF receptor , and are similar to the previously characterized suppressive effects of insulin on IGFBP 1 transcription mediated through the insulin receptor . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| As compared to authentic IGF 2 , insulin receptor reactivities and IGF 2 receptor reactivities of tumor extracted IGF 2 increased in two of three patients . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| RESULTS : IGF 1 , IGF 2 , the type 1 receptor , the insulin receptor , and IGFBP 2 6 are constitutively expressed in porcine myocardium . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| Expression of insulin like growth factor 1 ( IGF 1 ) and IGF 2 and the IGF 1 , IGF 2 , and insulin receptor genes and localization of the gene products in the human ovary . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| Immunofluorescence microscopy was carried out on twelve meningotheliomatous meningiomas using antibodies directed against insulin , IGF 1 , IGF 2 , insulin receptor and IGF 1 receptor . ^^^ The pattern of distribution of IGF 2 and the insulin receptor was especially regional . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| In order to provide a substrate for the better understanding of the roles of these growth factors , we have investigated the anatomical distribution as well as the variation in the density of [ 125I ] IGF 1 , [ 125I ] IGF 2 , and [ 125I ] insulin receptor binding sites in developing and adult rat brain by in vitro quantitative autoradiography . ^^^ The distributional profile of [ 125I ] IGF 1 , [ 125I ] IGF 2 , and [ 125I ] insulin receptor binding sites showed a widespread but selective regional localization throughout the brain at all stages of development . ^^^ Furthermore , the localization of [ 125I ] IGF 1 , [ 125I ] IGF 2 , and [ 125I ] insulin receptor binding sites over a wide variety of physiologically distinct brain regions suggests possible involvement of these growth factors in a variety of functions associated with specific neuronal pathways . . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Messenger RNA expression consistent with both known forms of the insulin receptor , the IGF 1 receptor , and the IGF 2 receptor was observed in human fetal ovaries and uteri at 10 , 15 , 19 , and 22 weeks ' gestation . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| The GTI 7 cells expressed all three members of the insulin receptor family as determined by analysis of 125I IGF 1 , 125I IGF 2 and 125I insulin binding sites . ^^^ A 100 fold higher dose of IGF 2 was required to produce a similar level of mitogenicity , implicating an action through the IGF 1 and / or insulin receptor . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| Reverse transcription polymerase chain reaction ( RT PCR ) analyses showed that mRNAs encoding insulin , IGF 2 , insulin receptor , and IGF 1 receptor were present in both precardiac mesoderm and endoderm , as well as in the forming heart at stage 8 . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| Taken together , these data indicate that cAMP , similar to its effects on the glucose transporter GLUT 4 and the insulin receptor , may increase the proportion of functionally cryptic IGF 2 receptors in the PM through mechanisms involving serine phosphorylation , possibly of a docking or coupling protein . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| Distribution and levels of insulin like growth factor ( IGF 1 and IGF 2 ) and insulin receptor binding sites in the spinal cords of amyotrophic lateral sclerosis ( ALS ) patients . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| We demonstrated that in rat adipocytes both acute insulin effects , e . g . stimulation of IGF 2 and transferrin binding and a chronic effect , insulin receptor downregulation , were stimulated by vanadate . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| CONCLUSION : IGF 2 , a peptide that binds to the insulin receptor and whose mRNA is rapidly transcribed by cardiac myocytes following ischemic stress , is cardioprotective and mimics ischemic preconditioning . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| Most of the actions of both IGF 1 and IGF 2 are mediated by their activation of the IGF 1 receptor , a transmembrane tyrosine kinase that is structurally and functionally related to the insulin receptor . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| However , when R cells overexpress the insulin receptor from a stably integrated plasmid , R / IR cells , they become capable of growing in serum free medium supplemented solely with insulin or IGF 2 , but not with IGF 1 . ^^^ From these results , we conclude that IGF 2 can stimulate cell proliferation not only through its cognate IGF1R but also through the insulin receptor . . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| Early bovine embryos also express IGF 1 , IGF 2 , IGF 1 receptor , IGF 2 receptor , and insulin receptor mRNAs . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| The Igf1r / Insr double nullizygotes are phenotypically indistinguishable from double mutants lacking IGF1R and IGF 2 and from other double and triple mutants in which all of the IGF ligand / receptor interactions have been eliminated . ^^^ Growth promoting interaction of IGF 2 with the insulin receptor during mouse embryonic development . ^^^ Therefore , these results provide genetic evidence that the growth promoting function of IGF 2 during mouse embryogenesis is mediated in part by signaling through the insulin receptor . . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| Distribution and levels of [ 125I ] IGF 1 , [ 125I ] IGF 2 and [ 125I ] insulin receptor binding sites in the hippocampus of aged memory unimpaired and impaired rats . ^^^ It thus appears that IGF 1 , IGF 2 and insulin receptor sites are not markedly altered during the normal ageing process in the Long Evans rat , in spite of significant learning deficits in a sub group ( memory impaired ) of aged animals . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| The 135 kDa band ( insulin receptor alpha subunit ) was the main one in the microvillous membranes ( 48 % total bound 125I IGF 2 ) . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| Peri implantation mouse embryos synthesize insulinlike growth factor ( IGF ) 2 ligand , insulin receptor , IGF 1 receptor , and IGF 2 receptor and respond to IGF 2 , IGF 1 , and insulin metabolically and mitogenically . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| Expression of mRNA encoding for IGF 1 , IGF 2 , IGF receptor 1 and 2 , IGF binding proteins 1 to 6 , insulin receptor and insulin was determined in the NIH MCF 7 breast cancer cell line , in specimens from breast cancer tissues , and in 6 primary breast cancer cell cultures obtained from metastatic breast cancer , using rT PCR technique . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| The type 1 IGF receptor , a tyrosine kinase receptor highly homologous to the insulin receptor , binds IGF 1 and IGF 2 with a high affinity . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| Earlier studies with both cultured cells and transgenic mice , however , have suggested that in the embryo the insulin receptor ( IR ) may also be a receptor for IGF 2 . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| Our results suggest that in the case of DNA synthesis the effects of IGF 2 are mediated via the IGF 1 receptor and those of insulin via the insulin receptor , whereas in the case of glycogenesis both are mediated via the insulin receptor . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| This decrease in bioavailable IGF 2 ultimately resulted in diminished IGF 1 receptor signaling in vivo as evidenced by diminished receptor kinase activity and decreased tyrosine phosphorylation of the IGF 1 receptor downstream effectors , insulin receptor substrate 1 ( IRS 1 ) , extracellular signal regulatory kinase ( Erk ) 1 , and Erk 2 . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| Quantitation of IGF 1 , IGF 2 , and multiple insulin receptor family member messenger RNAs during embryonic development in rainbow trout . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| The kinase activity of insulin receptor agonist complexes increased in the order of IGF 2 < IGF 1 < insulin , and neither vanadium ions nor thiazolidine type medicines for NIDDM , troglitazone and pioglitazone , directly acted on both the kinase reaction of insulin receptor or the binding of pY 939 to SH2N . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| RT PCR analysis detected insulin , IGF 2 , insulin receptor , and IGF receptor mRNAs in both the neural tube and the somites , whereas IGF 1 transcripts were detected in entire embryos but not in the neural tube or somites . ^^^ Treatment of somite neural tube cocultures with anti insulin , anti IGF 2 , anti insulin receptor , or anti IGF receptor blocking antibodies caused a significant decrease in myogenesis . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| Recently , we identified the insulin receptor isoform A ( IR ( A ) ) as an additional high affinity receptor for IGF 2 in both fetal and cancer cells . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| Insulin receptor mediates prenatal growth in response to IGF 2 and postnatal metabolism in response to insulin . ^^^ The ability of the insulin receptor to act as a bona fide IGF 2 dependent growth promoter is underscored by its rescue of double knockout Igf1r / Igf2r mice . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| However , the estrogen receptor ( ER ) content remained similar in tumors from both groups , at least at the protein level , and so did the expression of IGF 1 , IGF 2 , insulin receptor substrate 1 ( IRS 1 ) , IRS 2 and epidermal growth factor receptor . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| We designed and developed nine different calibration curves , based on recombinant DNA plasmid standards and established them on a constant real time PCR platform for the following factors : growth hormone receptor ( GHR ) , insulin like growth factor ( IGF ) 1 , IGF 1 receptor ( IGF 1R ) , IGF 2 , IGF 2 receptor ( IGF 2R ) , insulin receptor ( INSR ) , and IGF binding proteins ( IGF BP ) 1 , 2 and 3 . ^^^ Applicability of the method was shown by analysing mRNA levels in newborn calves : mRNA concentrations per gram tissue of mRNAs of IGF 1 , IGF 1R , IGF 2 , IGF 2R , GHR , INSR , and IGF BP 1 , 2 and 3 were all different between in liver and ileum and the traits all exhibited individual differences . . ^^^ Real time RT PCR quantification of insulin like growth factor ( IGF ) 1 , IGF 1 receptor , IGF 2 , IGF 2 receptor , insulin receptor , growth hormone receptor , IGF binding proteins 1 , 2 and 3 in the bovine species . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| In the present study , we investigated the effect of kindling on [ 125I ] IGF 1 , [ 125I ] IGF 2 and [ 125I ] insulin receptor binding in the hippocampus of adult rats . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| Direct binding of ( 125 ) 1 IGF 2 to the insulin receptor was visualized by cross linking and immunoprecipitation . ^^^ Binding of IGF 2 to the insulin receptor and a proliferative effect of insulin suggest the presence of insulin receptor isoform A . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| In IGF 1 receptor deficient leiomyosarcoma cells autocrine IGF 2 induces cell invasion and protection from apoptosis via the insulin receptor isoform A . ^^^ One of the two isoforms of the human insulin receptor ( isoform A or IR A ) binds IGF 2 with high affinity and is predominantly expressed in fetal tissues and malignant cells . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| IGF binding protein 5 , IGF 2 , and insulin receptor substrate 1 all displayed altered patterns and levels of expression in C / EBPbeta ( null ) mice , suggestive of a change in the IGF signaling axis . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| However , only 5 . 3 % of hybrid embryos developed into blastocyst stage compared to 21 . 7 % in buffalo . mRNA phenotyping of insulin like growth factor family ( Insulin , insulin receptor , IGF 1 , IGF 1 receptor , IGF 2 , and IGF 2 receptor ) and glucose transporter isoforms ( GLUT 1 , 2 , 3 , 4 ) in hybrid embryos clearly showed that these molecules were not expressed after 8 cell stage onward . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| The A isoform of the insulin receptor ( IR ) is frequently overexpressed in cancer cells and is activated by IGF 2 as well as by insulin , whereas the B isoform is predominant in differentiated tissues and responds poorly to IGF 2 . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| E 2 treatment of breast cancer cells alters expression of nearly all of the IGF family members including IGF 1 , IGF 2 , IGF binding proteins , IGF type 1 receptor ( IGF RI ) , and insulin receptor substrate 1 . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| The transcripts of IGF 1 , IGF 2 , IGF receptor ( IGF R ) , two IGF binding proteins ( IGFBP 2 and IGFBP 5 ) , GH receptor ( GH R ) and insulin receptor ( 1 R ) were measured by RT PCR at 4 , 8 , 12 and 16 weeks of age in the ovaries of ad libitum fed and feed restricted hens . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| The angiogenic response of IGF 2 could be reversed by the addition of beta galactosidase or rabbit antihuman IGF II / M6P receptor antiserum , whereas blocking antibodies against IGF 1 receptor or insulin receptor influenced IGF 2 induced sprout formation . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| Isoform A of the human insulin receptor and the IGF receptor type 2 ( IGFR 2 ) are both receptors for insulin like growth factor 2 ( IGF 2 ) , which plays a major role in luteal development and function in bovine species . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| Activation of the exon 11 insulin receptor by IGF 2 and insulin results in mitogenic effects and a potentiation of the cancer phenotype . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| In colostrum fed calves , DEXA decreased ( P < 0 . 05 ) mRNA levels of IGF 1 ( esophagus , fundus , duodenum , and ileum ) , IGF 2 ( fundus ) , IGFBP 2 ( fundus ) , IGFBP 3 ( fundus ) , IGF1R ( esophagus , ileum , and colon ) , IGF2R ( fundus ) , GHR ( fundus ) , and InsR ( esophagus , fundus ) , but in formula fed calves DEXA increased mRNA levels of IGF 1 ( esophagus , rumen , jejunum , and colon ) . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| We studied by real time reverse transcription PCR , whether there are differences in the abundance of mRNA coding for IGF 1 , IGF 2 , IGFBP 2 , IGFBP 3 , IGF 1R , IGF 2R , GHR , and InsR in compartmentalized layers ( fractions ) of jejunum and ileum of 5 d old calves fed colostrum . ^^^ In ileum , mRNA levels , expressed relative to housekeeping genes , differed ( P < 0 . 05 ) between fractions for IGF 1 ( LP > villi , crypts ) , IGF 2 , and IGFBP 3 ( villi > crypts , LP ) , GHR and InsR ( crypts > LP ) , IGFBP 2 ( crypts > villi , LP ) , and total RNA levels were greater ( P < 0 . 05 ) in LP and crypt than in villus fractions . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| Normal testicular tissues from autopsy cases and seminoma from surgery cases were obtained for microarray and real time reverse transcription polymerase chain reaction ( RT PCR ) analysis of IGF 1 , IGF 2 , IGF receptor type 1 ( IGF R 1 ) , IGF R 2 , insulin receptor isoforms A ( IR A ) and B ( IR B ) , and IGF binding proteins ( IGFBP ) 1 6 . ^^^ |
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| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| However , IGF 2 can also bind with high affinity to , and effectively activate , an isoform of the insulin receptor ( IR A ) that lacks a sequence at the carboxyl terminal end of the extracellular alpha subunit due to the alternative splicing of exon 11 . ^^^ We further show that the C domains are responsible for the differential abilities of IGF 2 and IGF 1 to activate phosphorylation of insulin receptor substrate 1 and Akt , as well as their ability to induce migration and cell survival via the IR A . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| We studied expression of the ligands IGF 1 and IGF 2 , the inhibitory IGF binding protein 3 , the type 1 IGF receptor ( IGF IR ) , and the downstream mediator insulin receptor substrate 1 by immunohistochemistry in 56 tissue specimens ( 28 low grade and 28 high grade prostate adenocarcinomas ) . ^^^ IGF 1 and IGF 2 and insulin receptor substrate 1 immunoreactivity was higher in tumors from patients with preoperative prostate specific antigen serum levels 10 ng / mL or greater , and IGF 2 expression was correlated with Gleason score . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| We have been hypothesizing that targeting IGF 2 in addition to blocking its interaction with the IGF receptor type 1 ( IGF IR ) would also allow to block that portion of the signal transduction through the insulin receptor that is due to its interaction with IGF 2 . ^^^ The most potent neutralizer , IgG 1 m610 , inhibited phosphorylation of the IGF IR and the insulin receptor , as well as phosphorylation of the downstream kinases Akt and mitogen activated protein kinase with an IC ( 50 ) of the order of 1 nmol / L at IGF 2 concentration of 10 nmol / L . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| We show that the mutant FoxO 1 transgene prevents beta cell replication in 2 models of beta cell hyperplasia , 1 due to peripheral insulin resistance ( Insulin receptor transgenic knockouts ) and 1 due to ectopic local expression of IGF 2 ( Elastase IGF 2 transgenics ) , without affecting insulin secretion . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| Insulin like growth factor 1 ( IGF 1 ) , IGF 2 , and insulin have all been implicated in regulating several aspects of the malignant phenotype via the type 1 IGF receptor ( IGF1R ) and insulin receptor ( IR ) . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| These abnormalities were associated reduced expression of genes encoding insulin , IGF 2 , insulin receptor , IGF 1 receptor , and insulin receptor substrate 1 , and reduced ligand binding to the insulin and IGF 2 receptors . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| LoVo cells produced unprocessed pro IGF 1R protein , substantial levels of IGF 2 mRNA and mature InsR protein , consisting mainly of the InsR A isoform . ^^^ Insulin and IGF 2 promoted cell growth and pEGFR Tyr 845 , Tyr 1068 and Tyr 1173 activity and conversely , the insulin like growth factor 1 receptor ( IGF 1R ) / InsR inhibitor ABDP ( 1 muM ) inhibited growth and reduced pEGFR activity at all three tyrosine residues . pInsR and pAkt levels were increased after gefitinib treatment . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| The insulin receptor is expressed in two isoforms , IR A and IR B ; the former also functions as a high affinity receptor for IGF 2 and is implicated , along with IGF 1R , in malignant transformation . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| A similar difference was observed for binding affinity of insulin like growth factor 2 to the insulin receptor . ^^^ The affinity of insulin like growth factor 2 to the IGF II / Man 6 P receptor was considerably higher than for the insulin receptor . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| This paper reports on the analysis of the expression of insulin like growth factor 2 and insulin like growth factor 2 , insulin like growth factor 1 and insulin receptor messenger RNAs in vivo in isolated rat hepatocytes at various stages of development and in vitro in adult rat hepatocytes primary culture . ^^^ Insulin like growth factor 2 , insulin like growth factor 1 and insulin receptor messenger RNAs were also detected . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| The decrease in the insulin receptor binding activity is physiologically expressed as a dose dependent decrease of insulin responsiveness in the adipocyte with respect to two known responses , stimulation of insulin like growth factor 2 receptor binding and activation of the glucose transport system . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| Entorhinal cortex lesion induces differential responses in [ 125I ] insulin like growth factor 1 , [ 125I ] insulin like growth factor 2 and [ 125I ] insulin receptor binding sites in the rat hippocampal formation . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| Systemic administration of kainic acid induces selective time dependent decrease in [ 125I ] insulin like growth factor 1 , [ 125I ] insulin like growth factor 2 and [ 125I ] insulin receptor binding sites in adult rat hippocampal formation . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| In contrast , insulin like growth factor 2 and insulin receptor binding sites are found to be decreased in various regions of the hippocampus in kainate treated pups . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| Effects of voluntary ethanol drinking on [ 125I ] insulin like growth factor 1 , [ 125I ] insulin like growth factor 2 and [ 125I ] insulin receptor binding in the mouse hippocampus and cerebellum . ^^^ The present study was designed to determine if voluntary ethanol consumption over a 21 day period could alter [ 125I ] insulin like growth factor 1 , [ 125I ] insulin like growth factor 2 and [ 125I ] insulin receptor binding sites in the hippocampus and cerebellum areas known to be severely affected following chronic exposure to ethanol . ^^^ Mice with access to the ethanol solution drank an average of 5 . 35+ / 0 . 77 g of ethanol / kg body weight per day . [ 125I ] Insulin like growth factor 1 receptor binding sites were found to be significantly increased in all subfields of the hippocampal formation , but not in the cerebellum , of ethanol treated mice compared to controls . [ 125I ] Insulin like growth factor 2 and [ 125I ] insulin receptor binding sites , on the other hand , did not exhibit any alterations either in the hippocampus or cerebellum following chronic exposure to ethanol . ^^^ |
|
| Interacting proteins: P01344 and P06213 |
Pubmed |
SVM Score :0.0 |
| Structural determinants for high affinity binding of insulin like growth factor 2 to insulin receptor ( IR ) A , the exon 11 minus isoform of the IR . ^^^ |
|