Pubmed abstracts for Protein-Protein Interaction search result :


Interacting proteins: P01344 and P00747 Pubmed SVM Score :0.0
Secretion of gelatinases or plasminogen activators was unaltered by IGF 2 or IGFBP 1 . ^^^
Interacting proteins: P01344 and P00747 Pubmed SVM Score :0.0
We conclude from these results 1 ) that IGF 2 is involved in the autocrine control of PC 3 cell proliferation via the type 1 IGF receptor ; and 2 ) that this proliferation is directly dependent on IGF 2 bioavailability that itself is modulated by the limited IGFBP 3 proteolysis induced , at least in part , by urokinase type plasminogen activator and plasmin . . ^^^
Interacting proteins: P01344 and P00747 Pubmed SVM Score :0.0
Under basal conditions , neuroblastoma cells secrete IGFs ( essentially IGF 2 ) , IGFBPs ( IGFBP 4 and predominantly IGFBP 2 that is partially proteolysed ) , and proteases , including tissue type plasminogen ( PLG ) activator , whose activity is inhibited by PLG activator inhibitor 1 . ^^^ In cells treated with 5 micrograms / ml PLG , proliferation was stimulated , an effect that was inhibited in the presence of either alpha IR 3 ( which blocks the type 1 IGF receptor ) or anti IGF 2 antibodies . ^^^
Interacting proteins: P01344 and P00747 Pubmed SVM Score :0.0
By using in situ hybridization , RNase protection assays , indirect immunofluorescence , Western blots , and bioassays , we show 1 ) the presence of insulin like growth factor 2 ( IGF 2 ) , IGF 2 receptor ( IGF IIR ) , IGF IR , TGF beta , plasminogen , plasminogen activators [ urokinase plasminogen activator ( uPA ) and tissue plasminogen activator ( tPA ) ] , and Cdk 4 in developing palates ; 2 ) on embryonic day 14 ( E 14 ) , which is a critical day for palatal growth , B10 . ^^^
Interacting proteins: P01344 and P00747 Pubmed SVM Score :0.0
Four different classes of ligands are presently known , binding to distinct sites at the extracytoplasmic receptor domain : mannose 6 phosphate containing lysosomal enzymes , the non glycosylated IGF 2 , retinoic acid , and urokinase type plasminogen activator receptor . ^^^
Interacting proteins: P01344 and P00747 Pubmed SVM Score :0.0
These results are particularly relevant in the light of the recent report that the urokinase type plasminogen activator receptor , a protein that also binds VN , has been shown to associate with the cation independent mannose 6 phosphate / IGF 2 receptor and suggest a possible role for IGF 2 in cell adhesion and invasion . . ^^^
Interacting proteins: P01344 and P00747 Pubmed SVM Score :0.0
RESULTS : Treatment of a rhabdomyosarcoma cell line which has a silent , methylated H 19 gene with histone deacetylase ( HDAC ) inhibitors under conditions which gave maximal hyperacetylation of histone 4 , both globally and at the H 19 gene itself could not reactivate H 19 or affect the active Insulin like Growth Factor 2 ( IGF 2 ) gene , but caused clear up regulation of the Tissue type Plasminogen Activator ( TPA ) gene , a non imprinted gene known to respond to changes in histone acetylation . ^^^
Interacting proteins: P01344 and P00747 Pubmed SVM Score :0.0
IGF 2 induced migration was abolished by insulin like growth factor binding protein 6 ( IGFBP 6 ) ( P < 0 . 01 ) , a relatively specific inhibitor of IGF 2 , and by plasminogen activator inhibitor type 1 ( PAI 1 ) ( P < 0 . 05 ) . ^^^
Interacting proteins: P01344 and P00747 Pubmed SVM Score :0.0
Seventy two PCOS patients and 42 healthy controls were genotyped for 15 variants in the genes encoding for paraoxonase ( three variants ) , plasma cell differentiation antigen glycoprotein , human sorbin and SH 3 domain containing 1 , plasminogen activator inhibitor 1 , peroxisome proliferator activated receptor gamma 2 , protein tyrosine phosphatase 1B ( two variants ) , adiponectin ( two variants ) , IGF 1 , IGF 2 , IGF 1 receptor , and IGF 2 receptor . ^^^
Interacting proteins: P01344 and P00747 Pubmed SVM Score :0.0
Interaction of insulin like growth factor 2 ( IGF 2 ) with multiple plasma proteins : high affinity binding of plasminogen to IGF 2 and IGF binding protein 3 . ^^^ IGF 2 ligand blotting and surface plasmon resonance spectrometry have been used to identify plasminogen as a novel high affinity IGF 2 binding protein capable of binding to IGFBP 3 with 50 fold higher affinity than transferrin . ^^^ In combination with transferrin , the overall binding constant of plasminogen / transferrin for IGF 2 was reduced 7 fold . ^^^ Size exclusion chromatography of the IGF 2 matrix eluate revealed that transferrin , plasminogen , and the IGFBP 3 protease are present in different high molecular mass complexes of > or =440 kDa . ^^^
Interacting proteins: P01344 and P00747 Pubmed SVM Score :0.0
The addition of insulin like growth factor 2 or transforming growth factor beta 1 was observed to alter , in a dose dependent manner , the expression of plasminogen activator and plasminogen activator inhibitor by connective tissue cells . ^^^ As the major effect of insulin like growth factor 2 and transforming growth factor beta 1 on the cells tested was to increase plasminogen activator inhibitor activity , such an alteration should diminish the activity of plasminogen activator , an enzyme capable of directly and indirectly proteolyzing matrix molecules , and thus contribute to a more anabolic environment . . ^^^
Interacting proteins: P01344 and P00747 Pubmed SVM Score :0.0
In contrast , compared with mRNA in the lateral meniscus , that for types 2 and 3 collagen , biglycan , insulin like growth factor 2 , plasminogen activator inhibitor 1 , and matrix metalloprotease 1 was significantly increased in the medial meniscus of mature rabbits only and that for versican and type 1 collagen was significantly increased in the medial meniscus of immature rabbits only . ^^^
Interacting proteins: P01344 and P00747 Pubmed SVM Score :0.0
Genes in the latter category include tissue plasminogen activator , insulin like growth factor 2 , PC 3 gene product , myelin basic protein , regulator of G protein signaling 5 , utrophin , IkappaB , connexin 45 , the class 1 major histocompatibility complex , the rat homologue of the transcription factors hbrm or EZH 1 , and organic anion transporting polypeptide type 2 . ^^^
Interacting proteins: P01344 and P00747 Pubmed SVM Score :0.0
We also show that alterations in the distribution of VE cadherin and beta catenin occur after IGFII and serum or VN stimulation , and propose that the via VN IGFII effects may be facilitated by interaction of the mannose 6 phosphate / IGFII receptor ( M6P / IGFIIR ) with the urokinase type plasminogen activator receptor ( uPAR ) and its ligand ( uPA ) . ^^^
Interacting proteins: P01344 and P00747 Pubmed SVM Score :0.0
NA
Interacting proteins: P01344 and P00747 Pubmed SVM Score :0.0
NA
Interacting proteins: P01344 and P00747 Pubmed SVM Score :0.0
NA
Interacting proteins: P01344 and P00747 Pubmed SVM Score :0.0
NA
Interacting proteins: P01344 and P00747 Pubmed SVM Score :0.0
NA
Interacting proteins: P01344 and P00747 Pubmed SVM Score :0.0
NA
Interacting proteins: P01344 and P00747 Pubmed SVM Score :0.0
NA
Interacting proteins: P01344 and P00747 Pubmed SVM Score :0.0
NA
Interacting proteins: P01344 and P00747 Pubmed SVM Score :0.0
NA
Interacting proteins: P01344 and P00747 Pubmed SVM Score :0.0
NA
Interacting proteins: P01344 and P00747 Pubmed SVM Score :0.0
NA
Interacting proteins: P01344 and P00747 Pubmed SVM Score :0.0
NA
Interacting proteins: P01344 and P00747 Pubmed SVM Score :0.0
NA
Interacting proteins: P01344 and P00747 Pubmed SVM Score :0.0
NA
Interacting proteins: P01344 and P00747 Pubmed SVM Score :0.0
NA
Interacting proteins: P01344 and P00747 Pubmed SVM Score :0.0
NA
Interacting proteins: P01344 and P00747 Pubmed SVM Score :0.0
NA
Interacting proteins: P01344 and P00747 Pubmed SVM Score :0.0
NA
Interacting proteins: P01344 and P00747 Pubmed SVM Score :0.0
NA
Interacting proteins: P01344 and P00747 Pubmed SVM Score :0.0
NA