i2d



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I2D

I2D is designed to be both a resource for the laboratory scientist to explore known and predicted protein-protein interactions, and to facilitate bioinformatics initiatives exploring protein interaction networks.
Source Interactions: 229,577
Predicted Interactions: 201,817
Total Interactions: 424,066

I2D will continue to expand as new protein-protein interaction data becomes available.

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Example: The ARP2/3 complex is composed of 7 protein subunits, and modulates actin polymerization. I2D includes 5 of these subunits, mapped from S.cerevisiae, in a highly connected complex.

References:

Brown, K.R., and Jurisica, I. (2007) Unequal evolutionary conservation of human protein interactions in interologous networks.
Genome Biology, 8(5):R95. PubMed | PDF

Brown, K.R., and Jurisica, I. (2005) Online Predicted Human Interaction Database.
Bioinformatics, 21(9):2076-82. PubMed | PDF