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Aliases & Descriptions for TUFT1
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases OTTHUMP00000014511 2
Search outside databases for aliases for TUFT1 genePrevious GC identifers: GC01P149354 GC01P147260 GC01P148287 GC01P148729 GC01P148325
Summaries for TUFT1 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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UniProtKB/Swiss-Prot: TUFT1_HUMAN, Q9NNX1 Function : Involved in the mineralization and structural organization of enamel
Gene Wiki entry for TUFT1 (Tuftelin)
Genomic Location for TUFT1
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the TUFT1 gene Entrez Gene cytogenetic band: 1q21 Ensembl cytogenetic band: 1q21.3 HGNC cytogenetic band: 1q21 TUFT1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01P149779:
(about GC identifiers )
Start:
149,779,405 bp from pter
End:
149,822,683 bp from pter
Size:
43,279 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000001.9 NT_004487.18 Proteins for TUFT1
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: TUFT1_HUMAN, Q9NNX1 (See
protein sequence )Recommended Name: Tuftelin Size : 390 amino acids; 44264 Da
Subunit : Interacts with TFIP11 (By similarity)
Subcellular location : Secreted (By similarity). Note=Secreted at a very early stage of enamelformation, concentrated at the dentin-enamel junction and tightly bound to the surface of thegrowing crystallites (By similarity)
Secondary accessions : Q5T384 Q5T385 Q9BU28 Q9H5L1Alternative splicing : 3 isoforms : Q9NNX1-1 Q9NNX1-2 Q9NNX1-3
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (2 alternative transcripts):
NP_001119809.1 NP_064512.1 ENSEMBL proteins: ENSP00000357842 ENSP00000357841 ENSP00000343781 ENSP00000376476 Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: TUFT1 2 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for TUFT1: Assays for TUFT1:
Protein
Domains/ Families for TUFT1(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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ProtoNet protein and cluster: Q9NNX1
UniProtKB/Swiss-Prot: TUFT1_HUMAN, Q9NNX1 Similarity : Belongs to the tuftelin family
Gene Function for TUFT1
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
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Clones , and
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Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_020127 Applied Biosystems Silencer ® siRNAs for TUFT1 Sigma-Aldrich siRNA for TUFT1 Sigma-Aldrich shRNA Panels and shRNA for TUFT1 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001126337                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001126337                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001126337  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_020127 UniProtKB/Swiss-Prot: TUFT1_HUMAN, Q9NNX1 Function : Involved in the mineralization and structural organization of enamel
Genatlas biochemistry entry for TUFT1 :tuftelin,acidic enamelin protein,that plays a major role in the mineralization and structuralorganization of enamel 1 Gene Ontology (GO) molecular function term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0030345 structural constituent of tooth enamel
NAS 12489194
About this table
Pathways & Interactions for TUFT1
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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5/8 Interacting proteins for TUFT1 (ENSP00000357842 3 ) via UniProtKB, MINT, and/or STRING (see all 8
)About this table 2 Gene Ontology (GO) biological process terms (links to tree view) :
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Drugs & Compounds for TUFT1 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for TUFT1 1 Novoseek chemical compound relationship for TUFT1 gene
Compound
Score
Articles
PubMed IDs for Articles with Shared Sentences (# sentences)
gold
19.33
1
7626400 (1)
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Transcripts for TUFT1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
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OriGene ,
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_020127 Sigma-Aldrich siRNA for TUFT1 Sigma-Aldrich shRNA Panels and shRNA for TUFT1 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001126337 NM_020127
REFSEQ mRNAs for TUFT1 gene (2 alternative transcripts): NM_001126337.1 NM_020127.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001126337 NM_020127
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001126337                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001126337                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001126337  
Additional cDNA sequence: AF086205.1 AF254260.1 AK026989.1 AK075001.1 AK223161.1 AK298066.1 AK299263.1 AK299925.1 AK315414.1 AL136917.1 AY358610.1 BC002933.1 BC008301.1
8 DOTS entries : DT.95267565 DT.100776330 DT.210831 DT.91749693 DT.121361234 DT.40298072 DT.121361244 DT.99985438
24/64 AceView cDNA sequences (see all 64
):BQ719901 AI458334 AI168826 BM464349 BU192294 BQ958944 BQ887143 BX504930 AL043356 BQ425395 BP342044 BE903227 AA400891 BE733924 BQ945826 AK075001 AI699870 AL603195 BM786473 AF086205 AL136917 AI925461 BQ072206 AA456800
highest scoring ESTs for TUFT1 :AK026989 AL043356 BG117276 BI053941 BQ351637 BQ360710 BQ425395 BQ719901 BQ945826 CA487739
Unigene Cluster for TUFT1: Tuftelin 1 Hs.489922 [show with all ESTs ] Unigene Representative Sequence: NM_020127 GeneLoc Exon Structure 4 Alternative Splicing Database (ASD) splice patterns (SP) for TUFT1 ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 SP1 :   -   -     -           -                   SP2 :                                     SP3 :     -   -   -                             SP4 :                                    
About this scheme ECgene alternative splicing isoforms for TUFT1 4 Ensembl transcripts including schematic representations : ENST00000368849
ENST00000368848
ENST00000353024
ENST00000392712
Expression for TUFT1
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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TUFT1 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for TUFT1 1 / 2 / 3
2 probe-sets matching TUFT1 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: TTTCTTCCCTSOURCE GeneReport for Unigene cluster: Hs.489922
Orthologs for TUFT1
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for TUFT1 gene from 5/7 species (see all 7
)
About this table Species with no ortholog for TUFT1 ENSEMBL Gene Tree for TUFT1 Paralogs for TUFT1 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for TUFT1 gene CCDC68 2 GRINL1B 2
SNPs/Variants for TUFT1 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for TUFT1 (up to first 250kb)
Disorders & Mutations for TUFT1
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
Novoseek , PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 600087 2 Novoseek disease relationships for TUFT1 gene
About this table Human Genome Epidemiology Navigator: TUFT1 (1 document)
Medical News for TUFT1 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for TUFT1 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/40 PubMed articles for TUFT1 gene (see all 40
): Mapping of the human tuftelin (TUFT1) gene to chromosome 1 by fluorescence in situ hybridization. (PubMed id 7919663) 1, 2, 3, 4 Deutsch D.... Fisher L.W. (1994) The human tuftelin gene: cloning and characterization. (PubMed id 11733143) 1, 3, 4 Mao Z.... Deutsch D. (2001) The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414) 3, 4 Gregory S.G.... Bentley D.R. (2006) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 3, 4 Ota T....Sugano S. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166) 3, 4 Wiemann S.... Poustka A. (2001) The human tuftelin gene and the expression of tuftelin in mineralizing and nonmineralizing tissues. (PubMed id 12489194) 1, 3 Deutsch D....Mao Z. (2002) Enamel formation genes are associated with high caries experience in Turkish children. (PubMed id 18781068) 1, 3 Patir A....Vieira A.R. (2008) The LIFEdb database in 2006. (PubMed id 16381901) 3 Mehrle A....Wiemann S. (2006) From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336) 3 Wiemann S....Poustka A. (2004)
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Genome Databases showing TUFT1
(According to
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euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
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Other Databases showing TUFT1
(According to HUGE )
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Specialized Databases showing TUFT1 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for TUFT1 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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