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Aliases & Descriptions for TUFT1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| OTTHUMP00000014511 2 |
| | | Descriptions |
|---|
| tuftelin 1 1, 2 |
|
| | Search outside databases for aliases for TUFT1 genePrevious GC identifers: GC01P149354 GC01P147260 GC01P148287 GC01P148729 GC01P148325 |
Summaries for TUFT1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: TUFT1_HUMAN, Q9NNX1Function: Involved in the mineralization and structural organization of enamelGene Wiki entry for TUFT1 (Tuftelin) |
Genomic Location for TUFT1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views
According to
UCSC and
Ensembl) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q21  Ensembl cytogenetic band: 1q21.3  HGNC cytogenetic band: 1q21TUFT1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P149779:  
(about GC identifiers)
Start:
|
149,779,405 bp from pter |
End:
|
149,822,683 bp from pter |
Size:
|
43,279 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000001.9 NT_004487.18
| Proteins for TUFT1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
BioMol,
Abnova, and/or
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
BioMol,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: TUFT1_HUMAN, Q9NNX1 (See
protein sequence)Recommended Name: Tuftelin Size: 390 amino acids; 44264 Da
Subunit: Interacts with TFIP11 (By similarity)
Subcellular location: Secreted (By similarity). Note=Secreted at a very early stage of enamel formation, concentrated at the dentin-enamel junction and tightly bound to the surface of the growing crystallites (By similarity)
Secondary accessions: Q5T384 Q5T385 Q9BU28 Q9H5L1Alternative splicing: 3 isoforms: Q9NNX1-1 Q9NNX1-2 Q9NNX1-3 Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins (2 alternative transcripts):
NP_001119809.1 NP_064512.1
ENSEMBL proteins: ENSP00000357842 ENSP00000357841 ENSP00000343781 ENSP00000376476
Human Recombinant Proteins
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for TUFT1: Assays for TUFT1:  | Protein
Domains/ Families for TUFT1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q9NNX1 UniProtKB/Swiss-Prot: TUFT1_HUMAN, Q9NNX1Similarity: Belongs to the tuftelin family | Gene Function for TUFT1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
1 OriGene genome-wide validation SYBR primer pairs: NM_020127 
siRNA: Applied Biosystems Silencer® siRNAs for TUFT1
UniProtKB/Swiss-Prot: TUFT1_HUMAN, Q9NNX1Function: Involved in the mineralization and structural organization of enamelGenatlas biochemistry entry for TUFT1:tuftelin,acidic enamelin protein,that plays a major role in the mineralization and structural organization of enamel1 Gene Ontology (GO) molecular function term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0030345 | structural constituent of tooth enamel |
NAS | 12489194 | About this table | Pathways & Interactions for TUFT1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
2 Gene Ontology (GO) biological process terms (links to tree view): About this table
5/8 Interacting proteins for TUFT1 (ENSP000003578423) via UniProtKB, MINT, and/or STRING (see all 8)About this table
|
Drugs & Compounds for TUFT1(Chemical Compounds according to UniProtKB, BioMol, Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
BioMol and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for TUFT1 1 Novoseek chemical compound relationship for TUFT1 gene 
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| gold |
19.33 |
1 |
7626400 (1) |
About this table
|
Transcripts for TUFT1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
HuSH-29 shRNA from
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
| 2 OriGene 29mer shRNA kit in GFP-retroviral vectors (4 constructs per gene plus two negative controls): NM_020127 NM_001126337 REFSEQ mRNAs for TUFT1 gene (2 alternative transcripts): NM_001126337.1 NM_020127.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001126337 NM_020127
Applied Biosystems Silencer® siRNAs: NM_001126337 NM_020127 2 OriGene GFP tagged cDNA clones in CMV expression vector: NM_001126337 NM_020127 2 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: NM_001126337 NM_020127 2 OriGene untagged cDNA clones in CMV expression vector: NM_001126337 NM_020127 Additional cDNA sequence: AF086205.1 AF254260.1 AK026989.1 AK075001.1 AK223161.1 AK298066.1 AK299263.1 AK299925.1 AK315414.1 AL136917.1 AY358610.1 BC002933.1 BC008301.1 8 DOTS entries: DT.95267565 DT.100776330 DT.210831 DT.91749693 DT.121361234 DT.40298072 DT.121361244 DT.99985438 24/64 AceView cDNA sequences (see all 64):BQ719901 AI458334 AI168826 BM464349 BU192294 BQ958944 BQ887143 BX504930 AL043356 BQ425395 BP342044 BE903227 AA400891 BE733924 BQ945826 AK075001 AI699870 AL603195 BM786473 AF086205 AL136917 AI925461 BQ072206 AA456800
highest scoring ESTs for TUFT1:AK026989 AL043356 BG117276 BI053941 BQ351637 BQ360710 BQ425395 BQ719901 BQ945826 CA487739 Unigene Cluster for TUFT1: Tuftelin 1 Hs.489922 [show with all ESTs]Unigene Representative Sequence: NM_020127
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for TUFT1
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | |
| SP1: |     |   |  -  |   |  -  |   |     |   |  -  |   |     |   |     |   |     |   |     |   |  -  |   |     |   |     |   |     |   |     |   |     |   |     |   |     |   |     |   | |
| SP2: |     |   |     |   |     |   |     |   |     |   |     |   |     |   |     |   |     |   |     |   |     |   |     |   |     |   |     |   |     |   |     |   |     |   |     |   | |
| SP3: |     |   |     |   |  -  |   |  -  |   |  -  |   |     |   |     |   |     |   |     |   |     |   |     |   |     |   |     |   |     |   |     |   |     |   |     |   |     |   | |
| SP4: |     |   |     |   |     |   |     |   |     |   |     |   |     |   |     |   |     |   |     |   |     |   |     |   |     |   |     |   |     |   |     |   |     |   |     |   |
About this scheme
ECgene alternative splicing isoforms for TUFT1
4 Ensembl transcripts including schematic representations: ENST00000368849
ENST00000368848
ENST00000353024
ENST00000392712
|
Expression for TUFT1
(Experimental results according to
1GeneNote
and GNF SymAtlas,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| TUFT1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for TUFT1
Expression according to 1 / 2 / 3 2 probe-sets matching TUFT1 geneData from
(Publications) and GNF SymAtlas (See also BioGPS) About these images About these images
CGAP SAGE TAG: TTTCTTCCCT
SOURCE GeneReport for Unigene cluster: Hs.489922
|
Orthologs for TUFT1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for TUFT1 gene from 5/7 species (see all 7)
About this table Species with no ortholog for TUFT1
ENSEMBL Gene Tree for TUFT1 | Paralogs for TUFT1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for TUFT1 gene
- CCDC682  GRINL1B2  
|
SNPs/Variants for TUFT1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for TUFT1 (up to first 250kb)
|
Disorders & Mutations for TUFT1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 600087
2 Novoseek disease relationships for TUFT1 gene 
About this table
Human Genome Epidemiology Navigator: TUFT1 (1 document) |
Medical News for TUFT1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for TUFT1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/40 PubMed articles for TUFT1 gene (see all 40):- Mapping of the human tuftelin (TUFT1) gene to chromosome 1 by fluorescence in situ hybridization. (PubMed id 7919663)1, 2, 3, 4 Deutsch D.... Fisher L.W. (1994)
- The human tuftelin gene: cloning and characterization. (PubMed id 11733143)1, 3, 4 Mao Z.... Deutsch D. (2001)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)3, 4 Gregory S.G.... Bentley D.R. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)3, 4 Wiemann S.... Poustka A. (2001)
- The human tuftelin gene and the expression of tuftelin in mineralizing and nonmineralizing tissues. (PubMed id 12489194)1, 3 Deutsch D....Mao Z. (2002)
- Enamel formation genes are associated with high caries experience in Turkish children. (PubMed id 18781068)1, 3 Patir A....Vieira A.R. (2008)
- The LIFEdb database in 2006. (PubMed id 16381901)3 Mehrle A....Wiemann S. (2006)
- From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)3 Wiemann S....Poustka A. (2004)
|
Search for TUFT1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing TUFT1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing TUFT1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TUFT1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for TUFT1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by BioMol and/or Tocris Bioscience) About This Section
| 
 Products for TUFT1:

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