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Aliases & Descriptions for T
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| MGC104817 2 | | OTTHUMP00000017588 2 | | TF 5 | | TFT 2 |
| | | Descriptions |
|---|
| T brachyury (mouse) homolog 1 | | T brachyury homolog 2 | | T brachyury-like 2 | | T protein 3 | | T, brachyury homolog (mouse) 2 | | transcription factor T 2 |
|
| | Search outside databases for aliases for T genePrevious GC identifers: GC06M165924 GC06M166444 GC06M166481 GC06M166482 |
Summaries for T(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for T: The protein encoded by this gene is an embryonic nuclear transcription factor that binds to a specific DNA element, the palindromic T-site. It binds through a region in its N-terminus, called the T-box, and effects transcription of genes required for mesoderm formation and differentiation. The protein is localized to notochord-derived cells. [provided by RefSeq] UniProtKB/Swiss-Prot: BRAC_HUMAN, O15178Function: Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site |
Genomic Location for T
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the T gene 
Entrez Gene cytogenetic band: 6q27 Ensembl cytogenetic band: 6q27 HGNC cytogenetic band: 6q27T Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M166541:
(about GC identifiers)
Start:
|
166,490,785 bp from pter |
End:
|
166,502,121 bp from pter |
Size:
|
11,337 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000006.10 NT_007422.13
| Proteins for T
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: BRAC_HUMAN, O15178 (See
protein sequence)Recommended Name: Brachyury protein Size: 435 amino acids; 47443 Da
Subunit: Monomer (By similarity)
Subcellular location: NucleusREFSEQ proteins: NP_003172.1
ENSEMBL proteins: ENSP00000296946 ENSP00000355836 ENSP00000355841
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for T:  | Invitrogen Antibodies for T |  | Millipore Mono- and Polyclonal Antibodies for the study of T |  | Sigma-Aldrich Antibodies for T |  | R&D Systems Antibodies for T (Brachyury) |  | Antibodies from Abcam (Brachyury / Bry), each with their AbpromiseSM |  | Monoclonal and Polyclonal Antibodies from Abnova (T) |  | Novus Biologicals Antibodies for T |
Assays for T: | Protein
Domains/ Families for T(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry O15178
ProtoNet protein and cluster: O15178 2 Blocks protein families: IPB001699 Transcription factor IPB002070 Brachyury protein family signature
UniProtKB/Swiss-Prot: BRAC_HUMAN, O15178Similarity: Contains 1 T-box DNA-binding domain | Gene Function for T
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003181
Applied Biosystems Silencer® siRNAs for T
Sigma-Aldrich siRNA for T  Sigma-Aldrich shRNA for T  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003181                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_003181                                  untagged cDNA clone in CMV expression vector: NM_003181 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_003181
UniProtKB/Swiss-Prot: BRAC_HUMAN, O15178Function: Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a siteGenatlas biochemistry entry for T:murine T-box gene Tbx (T,brachyury) homolog,expressed in cells derived from the notochord,crucial for mesoderm formation,no evidence of association with neural tube defects (NTD) in Netherlands and U.K.15/19 MGI mutant phenotypes (inferred from 37 alleles ) (MGI details for T) (see all 19
):
3 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for T
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
1 Sigma-Aldrich "Your Favorite Gene" Pathway for T (Your Favorite Gene powered by Ingenuity) 
5/12 Interacting proteins for T (ENSP000002969463) via UniProtKB, MINT, and/or STRING (see all 12
)About this table
5/13 Gene Ontology (GO) biological process terms (links to tree view) (see all 13
): About this table
|
Drugs & Compounds for T(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for T
|
Transcripts for T(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003181
Sigma-Aldrich siRNA for T  Sigma-Aldrich shRNA for T  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_003181 REFSEQ mRNAs for T gene: NM_003181.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_003181               OriGene GFP tagged cDNA clone in CMV expression vector: NM_003181                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_003181                                  untagged cDNA clone in CMV expression vector: NM_003181  Additional cDNA sequence: AJ001699.1 BC039877.1 BC098425.1 5 DOTS entries: DT.97837890 DT.202766 DT.97837889 DT.100737559 DT.75161871 24/48 AceView cDNA sequences (see all 48
):NM_003181 BQ931406 AI341816 BG332916 BQ221957 BQ420570 BC039877 AI651456 BQ221790 BG490984 AW003327 BE785653 BQ925830 BF512284 BU192473 AI797600 BU164583 BF223613 BG333106 BQ951069 AI001036 AA994493 BQ924827 BQ222875
highest scoring ESTs for T:AJ001699 BE789773 BG332994 BG333106 BG436736 BG436820 BQ927155 BU190437 AA994493 AI001036 Unigene Cluster for T: T, brachyury homolog (mouse) Hs.389457 [show with all ESTs]Unigene Representative Sequence: NM_003181
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for T
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | |
| SP1: | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for T
3 Ensembl transcripts including schematic representations: ENST00000296946
ENST00000366871
ENST00000366876
|
Expression for T
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| T expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for T
1 / 2 / 3 3 probe-sets matching T gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TGAAGCAGCA
SOURCE GeneReport for Unigene cluster: Hs.389457
Expression variation in blood from EXPOLDB for T |
Orthologs for T
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for T gene from 5/12 species (see all 12
)
About this table Species with no ortholog for T
ENSEMBL Gene Tree for T | Paralogs for T(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for T gene
- TBX192
|
SNPs/Variants for T(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for T (up to first 250kb)
|
Disorders & Mutations for T
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 601397 disorders: 182940 UniProtKB/Swiss-Prot: BRAC_HUMAN, O15178
Genetic variations in T are associated with susceptibility to neural tube defects (NTD) [MIM:182940]. NTD are common congenital malformations. Spina bifida, which results from malformations in the caudal region of the neural tube, is compatible with life but associated with significant morbidity, including lower limb paralysis3 Novoseek disease relationships for T gene
About this table
Human Gene Mutation Database: T Human Genome Epidemiology Navigator: T (0 documents)
|
Medical News for T(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for T (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/82 PubMed articles for T gene (see all 82
):- The human homolog T of the mouse T(Brachyury) gene; gene structure, cDNA sequence, and assignment to chromosome 6q27. (PubMed id 8963900)1, 2, 3, 4 Edwards Y.H....Sowden J. (1996)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)3, 4 Mungall A.J.... Beck S. (2003)
- The human T locus and spina bifida risk. (PubMed id 15449172)1, 4 Jensen L.E....Mitchell L.E. (2004)
- Brachyury expression in extra-axial skeletal and soft tissue chordomas: a marker that distinguishes chordoma from mixed tumor/myoepithelioma/parachordoma in soft tissue. (PubMed id 18301055)3 Tirabosco R....Flanagan A.M. (2008)
- Brachyury, SOX-9, and podoplanin, new markers in the skull base chordoma vs chondrosarcoma differential: a tissue microarray-based comparative analysis. (PubMed id 18820665)3 Oakley G.J....Seethala R.R. (2008)
- A Missense T(Brachyury) Mutation Contributes to Vertebral Malformations. (PubMed id 18466071)3 Ghebranious N....Giampietro P.F. (2008)
- Human TBX1 missense mutations cause gain of function resulting in the same phenotype as 22q11.2 deletions. (PubMed id 17273972)3 Zweier C.... Rauch A. (2007)
- The T-box repressors TBX2 and TBX3 specifically regulate the tumor suppressor gene p14ARF via a variant T-site in the initiator. (PubMed id 12000749)3 Lingbeek M.E....van Lohuizen M. (2002)
- Human T and risk for neural tube defects. (PubMed id 11897834)3 Richter B....Koch M.C. (2002)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
|
Search for T
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing T
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing T
(According to HUGE)
About This Section
| -- |
Specialized Databases showing T(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for T(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for T:

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