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SHB Gene

protein-coding   GIFtS: 54

GC09M037581
Src homology 2 domain containing adaptor protein B
(Previous names: SHB adaptor protein (a Src homology 2 protein), SHB (Src homology 2 domain containing) adaptor protein B )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases &
Descriptions
for SHB

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
OTTHUMP00000021397 2
RP11-3J10.8 2
bA3J10.2 2
Descriptions
SHB (Src homology 2 domain containing) adaptor protein B 1, 2
SHB adaptor protein (a Src homology 2 protein) 1, 2
Src homology 2 domain containing adaptor protein B 2
External Ids
HGNC: 108381
Entrez Gene: 64612
UniProtKB: Q154643
Ensembl: ENSG000001073387
Search outside databases for aliases for SHB gene

Previous GC identifers: GC09M038231 GC09M038089 GC09M037909

Summaries
for SHB

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: SHB_HUMAN, Q15464
Function: Adapter protein which regulates several signal transduction cascades by linking activated
receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1,
VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling,
interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and
NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing
cells

Gene Wiki entry for SHB

Genomic Location
for SHB

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the SHB gene  

Entrez Gene cytogenetic band: 9p13.2-p13.1   Ensembl cytogenetic band:  9p13.1   HGNC chromosome: 9

SHB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M037581:     (about GC identifiers)

Start:
 37,578,417 bp from pter
End:
 38,059,249 bp from pter
Size:
 480,833 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000009.10  NT_008413.17  

Proteins
for SHB

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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 UniProtKB/Swiss-Prot: SHB_HUMAN, Q15464 (See protein sequence)
Recommended Name: SH2 domain-containing adapter protein B  
Size: 509 amino acids; 55042 Da
Subunit: Interacts with PTPN11 (By similarity). Interacts with phosphorylated 'Tyr-720' of the
ligand-activated receptor PDGFRA via its SH2 domain. Interacts with the ligand-activated receptors
PDGFRB, FGFR1, KDR/VEGFR2, IL2RB and IL2RG. Interacts with EPS8 and V-SRC. Interacts with GRB2 and
GRAP. Interacts with CD3Z. Interacts with tyrosine-phosphorylated LAT upon T-cell antigen receptor
activation. Interacts with PLCG1. Interacts with ZAP70, LCP2/SLP-76, VAV1 and GRAP2. Interacts
with JAK1 and JAK3. Interacts with PTK2/FAK1. Interacts with CRK/CrKII. Interacts with IRS2
Subcellular location: Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Note=Associates with membrane lipid rafts upon TCR stimulation
Secondary accessions: Q504U5 Q5VUM8
Alternative splicing: 2 isoforms:  Q15464-1   Q15464-2   

Post-translational modifications:

  • Phosphorylated upon PDGFRA, PDGFRB, TCR, IL2 receptor, FGRF1 or VEGFR2 activation1
  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins: NP_003019.2  

    ENSEMBL proteins: 
    ENSP00000384411 ENSP00000366929 ENSP00000366936 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (SHB)
    Browse Abnova for Human Recombinant Proteins
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737 cytoplasm IEA--
    GO:0005886 plasma membrane IEA--
    About this table

    Antibodies for SHB: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (SHB), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (SHB)
    Search Novus for antibodies for SHB

    Assays for SHB: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for SHB

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro domain/family:
     IPR000980 SH2


       GeneDecks  SHB for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q15464

    ProtoNet protein and cluster: Q15464

    1 Blocks protein family: IPB000980 SH2 domain signature

    UniProtKB/Swiss-Prot: SHB_HUMAN, Q15464
    Domain: The SH2 domain preferentially binds phosphopeptides with the consensus sequence Y-[TVI]-X-L
    and mediates interaction with PDGFRA, PDGFRB, FGRFR1, IL2RB, IL2RG, CD3Z and CRK/CrKII
    Similarity: Contains 1 SH2 domain

    Gene Function
    for SHB

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (SHB)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003028

                  Applied Biosystems Silencer® siRNAs for SHB

                  Sigma-Aldrich siRNA for SHB  
                         Sigma-Aldrich shRNA for SHB  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_003028
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_003028
                                     untagged cDNA clones in CMV expression vector (see all 2): AK096227 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_003028

    UniProtKB/Swiss-Prot: SHB_HUMAN, Q15464
    Function: Adapter protein which regulates several signal transduction cascades by linking activated
    receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1,
    VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling,
    interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and
    NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing
    cells

    Genatlas biochemistry entry for SHB:
    adaptor protein,ubiquitously expressed with SH2 domain (?signal transduction)

    7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Shb):

    embryogenesislethality-prenatal/perinatallimbs/digits/tailnervous system
    no phenotypic analysisreproductive system

    2 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005070 SH3/SH2 adaptor activity TAS8302579
    GO:0005515 protein binding IEA--
    About this table

    Pathways & Interactions
    for SHB

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    1 Invitrogen iPath™ Online BioAtlas - Pathway for SHB (Maps provided by GeneGo):
     FGFR signaling pathway

       GeneDecks  SHB for the pathways selected above  
    About GeneDecksing

    1 Millipore Pathway for SHB
     Development FGFR signaling pathway

       GeneDecks  SHB for the pathways selected above  
    About GeneDecksing

    1 Sigma-Aldrich "Your Favorite Gene" Pathway for  SHB  (Your Favorite Gene powered by Ingenuity) 
     T Cell Receptor Signaling

       GeneDecks  SHB for the pathways selected above  
    About GeneDecksing

     Gene Network CentralTM Interacting Genes and Proteins Network for  SHB 

      --

    5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525 angiogenesis IEA--
    GO:0006915 apoptosis IEA--
    GO:0007165 signal transduction TAS8302579
    GO:0007275 multicellular organismal development IEA--
    GO:0030154 cell differentiation IEA--
    About this table

    Drugs & Compounds
    for SHB

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for SHB
    5 Novoseek chemical compound relationships for SHB gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 53.10 14 9751119 (2), 8806685 (2), 15026417 (1), 8777141 (1) (see all 6)
    phosphotyrosine 47.75 2 9484780 (1)
    phenylalanine 34.40 2 12200137 (1)
    phosphatidylinositol 28.30 2 15026417 (2)
    calcium 0.00 1 10488157 (1)
    About this table


    Transcripts
    for SHB

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (SHB)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003028

                  Sigma-Aldrich siRNA for SHB  
                         Sigma-Aldrich shRNA for SHB  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_003028  

    REFSEQ mRNAs for SHB gene: 

    NM_003028.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_003028  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_003028
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_003028
                                     untagged cDNA clones in CMV expression vector (see all 2): AK096227 

    Additional cDNA sequence: 

    AK055947.1 BC029953.1 BC136581.1 BC136582.1 X75342.1 

    9 DOTS entries:

    DT.75193214  DT.121192501  DT.121192683  DT.97784668  DT.100655154  DT.100746304  DT.100755540  DT.100755541 
    DT.121192533 

    20 AceView cDNA sequences:

    AW295062 BM967333 BQ958415 BG326702 BI962546 BE778005 AW302147 BV207870 
    CK821172 BM893981 BC029953 BE562483 BV184490 AI521954 BI789094 BQ439455 
    AI446569 BE042569 CD580276 BM545205 

    highest scoring ESTs for SHB:

    X75342 AA477174 AW025717 AW196917 AW241417 AW295062 BE385933 BE501067 BE501210 BE504742 

    Unigene Cluster for SHB:

    Src homology 2 domain containing adaptor protein B
    Hs.521482  [show with all ESTs]
    Unigene Representative Sequence: NM_003028


    GeneLoc Exon Structure

    3 Ensembl transcripts including schematic representations:
    ENST00000401811  ENST00000377700  ENST00000377707  

    Expression
    for SHB

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    SHB expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for SHB

    1 / 2 / 3

    13 probe-sets matching SHB gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    73118_at2, 3 U95-E 1 1.00 1.00 0.97 1.13 AW025717 0.60 1.00 0.82 1
    60524_at2, 3 U95-C 1 1.00 1.00 0.95 1.16 W46415 0.60 1.00 0.82 1
    40614_at2, 3 U95-A 2 1.00 0.69 0.95 0.75 X75342 0.80 0.88 0.84 1
    56416_at2, 3 U95-B 5 0.56 0.43 0.08 0.98 AA131252 0.20 0.12 0.17 3

    		204656_at2 U133-A 1 1.00 1.00 -- -- -- -- -- -- --

    		243595_at2, 3 U133-B 1 1.00 1.00 -- -- AI589280 0.20 1.00 0.72 1

    		204657_s_at2, 3 U133-A 2 1.00 0.77 -- -- NM_003028 0.60 1.00 0.82 1

    		225036_at2 U133-B 2 1.00 0.50 -- -- -- -- -- -- --

    		204656_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		243595_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		1557458_s_at2 U133Plus2 2 1.00 0.95 -- -- -- -- -- -- --

    		204657_s_at2 U133Plus2 2 1.00 0.77 -- -- -- -- -- -- --

    		225036_at2 U133Plus2 2 1.00 0.50 -- -- -- -- -- -- --
    GeneDecks  SHB for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.521482

    Expression variation in blood from EXPOLDB for SHB

    UniProtKB/Swiss-Prot: SHB_HUMAN, Q15464
    Tissue specificity: Widely expressed

    Orthologs
    for SHB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for SHB gene from 4 species
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 SHB1   -- Src homology 2 domain containing adaptor protein B 92.45(n)
    96.65(a)    		 481619  XM_538741.2  XP_538741.2 
    cow
    (Bos taurus)    		 SHB1   -- Src homology 2 domain containing adaptor protein B 91.91(n)
    97.24(a)    		 538275  XM_618475.3  XP_618475.3 
    mouse
    (Mus musculus)    		 Shb1, 5 45
    		 src homology 2 domain-containing transforming protein more1, 5 88.36(n)1
    94.21(a)1    		 2301261  XM_001474892.11  XP_001474942.11 
     AI8370375  AK1454145  (see all 9)
    chicken
    (Gallus gallus)    		 SHB1   -- Src homology 2 domain containing adaptor protein B 75.77(n)
    86.15(a)    		 427280  XM_424863.2  XP_424863.2 
    About this table        Species with no ortholog for SHB

    ENSEMBL Gene Tree for SHB

    Paralogs
    for SHB

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for SHB gene
    SHF2  SHE2  SHD2  

    SNPs/Variants
    for SHB

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/750 NCBI SNPs in SHB are shown (see all 750 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 295)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 9 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    rs22817841,2
    		A,C,F,H37909743(-) AGCCCA/GGCCAC 1 -- ut31 ese37Minor allele frequency- G:0.08EA WA NA 658
    rs38088621,2
    		A,C,F,H38060583(-) CCTCCC/TCTGGG 1 -- ng314Minor allele frequency- T:0.13EA WA 1788
    rs37475471,2
    		C,F,H37906408(+) AATGAT/CATCAC 1 -- ut315Minor allele frequency- C:0.12EA EU WA 1904
    rs37475461,2
    		C,F,H37906193(+) TTGCCG/AAATTT 1 -- ut318Minor allele frequency- A:0.04EA NA EU WA 2046
    rs37475451,2
    		F,H37906164(+) CTGTGC/TGCCCT 1 -- ut315Minor allele frequency- T:0.02EA EU WA 1914
    rs7061481,2
    		C,H37908109(-) TTGAAC/TGTCAT 1 -- ut317Minor allele frequency- T:0.00NA EA EU WA 668
    rs70450771,2
    		F,H38059875(+) TAGGCG/TGTGGG 1 -- ng314Minor allele frequency- T:0.01EU EA WA 418
    rs7760271,2
    		H37905601(+) ccgccT/Agtaat 1 -- ng514Minor allele frequency- A:0.00EU EA WA 420
    --
    rs109736101,2
    		A37908431(+) gtgtgC/Tgtgtg 1 -- ut310--------
    --
    rs20080461,2
    		A38060251(+) gctgaA/Ggcaga 1 -- ng310--------
    About this table

    HapMap Linkage Disequilibrium images for SHB (up to first 250kb)

    Disorders & Mutations
    for SHB

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 600314

    Human Genome Epidemiology Navigator: SHB (1 document)

    Medical News
    for SHB

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for SHB

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/35 PubMed articles for SHB gene (see all 35 ):

    Search for SHB

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SHB

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 6461 HGNC: 10838 AceView: SHB.1 Ensembl:ENSG00000107338 euGenes: HUgn6461
    ECgene: SHB H-InvDB: SHB

    Other Databases showing SHB

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing SHB

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    		   --

    Licensable Technologies
    for SHB

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for SHB

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for SHB:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for SHB-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for SHB Browse antibodies at Sigma-Aldrich
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for SHB Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Recombinant & Natural Proteins  

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     Search OriGene for SHB
     Search Tocris compounds for SHB




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Search Novus for antibodies for SHB

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