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Aliases & Descriptions for NOS1AP
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases 6330408P19Rik 2 CAPON 1 , 2 , 3 , 5 KIAA0464 1 , 3 , 5 MGC138500 2 OTTHUMP00000025714 2
Descriptions C--terminal PDZ ligand of neuronal nitric oxide synthase protein 3 C-terminal PDZ domain ligand of neuronal nitric oxide synthase (CAPON) 2 Nitric oxide synthase 1 adaptor protein 3 ligand of neuronal nitric oxide synthase with carboxyl-terminal PDZ domain 2 nitric oxide synthase 1 (neuronal) adaptor protein 2
Search outside databases for aliases for NOS1AP genePrevious GC identifer: GC01P158772
Summaries for NOS1AP (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for NOS1AP : This gene encodes a cytosolic protein that binds to the signaling molecule, neuronal nitric oxidesynthase (nNOS). This protein has a C-terminal PDZ-binding domain that mediates interactions withnNOS and an N-terminal phosphotyrosine binding (PTB) domain that binds to the small monomeric Gprotein, Dexras1. Studies of the related mouse and rat proteins have shown that this proteinfunctions as an adapter protein linking nNOS to specific targets, such as Dexras1 and thesynapsins. [provided by RefSeq] UniProtKB/Swiss-Prot: CAPON_HUMAN, O75052 Function : Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via itsassociation with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specificNO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 forinteraction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1and DLG4 (By similarity)
Gene Wiki entry for NOS1AP
Genomic Location for NOS1AP
(According to
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and/or miRBase ,
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the NOS1AP gene Entrez Gene cytogenetic band: 1q23.3 Ensembl cytogenetic band: 1q23.3 HGNC cytogenetic band: 1q23.3 NOS1AP Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01P160306:
(about GC identifiers )
Start:
160,306,205 bp from pter
End:
160,604,864 bp from pter
Size:
298,660 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000001.9 NT_004487.18 Proteins for NOS1AP
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: CAPON_HUMAN, O75052 (See
protein sequence )Recommended Name: Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein Size : 506 amino acids; 56150 Da
Subunit : Interacts with the PDZ domain of NOS1 or the second PDZ domain of DLG4 through itsC-terminus. Interacts with RASD1 and SYN1, SYN2 and SYN3 via its PID domain. Forms a ternarycomplex with NOS1 and RASD1. Forms a ternary complex with NOS1 and SYN1 (By similarity)
Secondary accessions : O43564 Q5VU95
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (2 alternative transcripts):
NP_001119532.2 NP_055512.1 ENSEMBL proteins: ENSP00000355133 Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: NOS1AP Antibodies for NOS1AP: Assays for NOS1AP:
Protein
Domains/ Families for NOS1AP(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry O75052 ProtoNet protein and cluster: O75052
UniProtKB/Swiss-Prot: CAPON_HUMAN, O75052 Similarity : Contains 1 PID domain
Gene Function for NOS1AP
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
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Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_001126060 Applied Biosystems Silencer ® siRNAs for NOS1AP Sigma-Aldrich siRNA for NOS1AP Sigma-Aldrich shRNA for NOS1AP Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001126060                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001126060                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001126060  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_014697 UniProtKB/Swiss-Prot: CAPON_HUMAN, O75052 Function : Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via itsassociation with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specificNO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 forinteraction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1and DLG4 (By similarity)
3 Gene Ontology (GO) molecular function terms (links to tree view) :
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Pathways & Interactions for NOS1AP
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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Gene Network CentralTM Interacting Genes and Proteins Network for NOS1AP 5/10 Interacting proteins for NOS1AP (O75052 1 ENSP00000355133 3 ) via UniProtKB, MINT, and/or STRING (see all 10
)About this table
Drugs & Compounds for NOS1AP (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for NOS1AP 1 Novoseek chemical compound relationship for NOS1AP gene
About this table
Transcripts for NOS1AP(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
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siRNAs from Applied Biosystems ,
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shRNA from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_001126060 Sigma-Aldrich siRNA for NOS1AP Sigma-Aldrich shRNA for NOS1AP Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001126060 NM_014697
REFSEQ mRNAs for NOS1AP gene (2 alternative transcripts): NM_001126060.1 NM_014697.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001126060 NM_014697
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001126060                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001126060                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001126060  
Additional cDNA sequence: AB007933.2 AF037070.1 AK024942.1 AY841899.1 BC041382.2 BC112295.1 BC143771.1 BC143780.1
7 DOTS entries : DT.431228 DT.101013 DT.95260314 DT.91928393 DT.97822347 DT.121423665 DT.87016478
24/58 AceView cDNA sequences (see all 58
):AI915161 AB007933 AF037070 AI150129 BX952349 NM_014697 BX281100 BM999232 AU131738 AA478926 AI802226 AI198232 AK125122 BG819229 AW136439 AW339403 CB306818 AI937609 CB054365 AU125189 AA129774 AI683194 AI559183 AA928879
highest scoring ESTs for NOS1AP :AB007933 AF037070 AI150129 AI198232 AU147312 BX281100 R19867 BC041382 AI797626 AY841899
Unigene Cluster for NOS1AP: Nitric oxide synthase 1 (neuronal) adaptor protein Hs.655000 [show with all ESTs ] Unigene Representative Sequence: AY841899 GeneLoc Exon Structure 1 Ensembl transcript including schematic representation : ENST00000361897
Expression for NOS1AP
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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NOS1AP expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for NOS1AP 1 / 2 / 3
4 probe-sets matching NOS1AP gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: GTGGTTTCTTSOURCE GeneReport for Unigene cluster: Hs.655000 Expression variation in blood from EXPOLDB for NOS1AP
Orthologs for NOS1AP
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for NOS1AP gene from 4 species
Organism
Gene
Locus
Description
Human Similarity
NCBI accessions
rat (Rattus norvegicus)
Nos1ap1
--
nitric oxide synthase 1 (neuronal) adaptor protein
90.15(n) 95.01(a)
192363 NM_138922.1 NP_620277.1
mouse (Mus musculus)
Nos1ap1 , 5
15
nitric oxide synthase 1 (neuronal) adaptor protein1, 5
90.27(n) 1 95.72(a) 1
70729 1 NM_027528.2 1 NP_081804.1 1 AK018149 5 AK045124 5 (see all 11 )
chicken (Gallus gallus)
NOS1AP1
--
nitric oxide synthase 1 (neuronal) adaptor protein
80.24(n) 82.46(a)
424371 XM_422215.2 XP_422215.2
African clawed frog (Xenopus laevis)
Xl.305042
--
Xenopus laevis transcribed sequence with weak similarity more
80.21(n)
BG364067.1
About this table Species with no ortholog for NOS1AP ENSEMBL Gene Tree for NOS1AP Paralogs for NOS1AP (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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--
SNPs/Variants for NOS1AP (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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UniProtKB/Swiss-Prot: CAPON_HUMAN, O75052 Polymorphism : Genetic variation in NOS1AP influences the electrocardiographic QT interval[MIM:610141]. The QT interval is defined as the time from the beginning of the Q wave to the endof the T wave, representing the duration of ventricular electrical activity. The QT interval, ameasure of cardiac repolarization, is a genetically influenced quantitative trait withconsiderable medical relevance: both high and low values are associated with increased risk ofcardiovascular morbidity and mortality
HapMap Linkage Disequilibrium images for NOS1AP (up to first 250kb)
Disorders & Mutations for NOS1AP
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
Novoseek , PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 605551 disorders : 610141
2 Novoseek disease relationships for NOS1AP gene
About this table Human Gene Mutation Database : NOS1AP Human Genome Epidemiology Navigator: NOS1AP (26 documents)
Medical News for NOS1AP (Possibly Related Articles in
Doctor's Guide )
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--
Publications for NOS1AP (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/42 PubMed articles for NOS1AP gene (see all 42
): CAPON: a protein associated with neuronal nitric oxide synthase that regulates its interactions with PSD95. (PubMed id 9459447) 1, 2, 3, 4 Jaffrey S.R....Snyder S.H. (1998) Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PubMed id 9455484) 2, 3, 4 Seki N....Ohara O. (1997) A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization. (PubMed id 16648850) 3, 4 Arking D.E.... Chakravarti A. (2006) The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414) 3, 4 Gregory S.G.... Bentley D.R. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Increased expression in dorsolateral prefrontal cortex of CAPON in schizophrenia and bipolar disorder. (PubMed id 16146415) 1, 3 Xu B....Brzustowicz L.M. (2005) Evidence for a role of the NOS1AP (CAPON) gene in schizophrenia and its clinical dimensions: an association study in a South American population isolate. (PubMed id 19077434) 1, 3 Kremeyer B....Ruiz-Linares A. (2009) CAPON modulates cardiac repolarization via neuronal nitric oxide synthase signaling in the heart. (PubMed id 18337493) 1, 3 Chang K.C....Marban E. (2008) Genetic variations in nitric oxide synthase 1 adaptor protein are associated with sudden cardiac death in US white community-based populations. (PubMed id 19204306) 1, 3 Kao W.H....Chakravarti A. (2009) Associations between genetic variants in the NOS1AP (CAPON) gene and cardiac repolarization in the old order Amish. (PubMed id 17565224) 1, 3 Post W....Shuldiner A.R. (2007)
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Genome Databases showing NOS1AP
(According to
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AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing NOS1AP
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Specialized Databases showing NOS1AP (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for NOS1AP (Reagents available from Applied Biosystems , Antibodies and assays by Cell
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