 |
 | Services
| |
 |
Aliases & Descriptions for NAALADL1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| EC 3.4.17.21 3 | | I100 2, 3, 5 | | NAALADASEL 2, 3 | | NAALADL 3 |
| | | Descriptions |
|---|
| 100 kDa ileum brush border membrane protein 2, 3 | | Ileal dipeptidylpeptidase 2, 3 | | N-acetylated alpha-linked acidic dipeptidase-like 1 2 | | NAALADase L 3 |
|
| | Search outside databases for aliases for NAALADL1 genePrevious GC identifer: GC11M064588 |
Summaries for NAALADL1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: NALDL_HUMAN, Q9UQQ1Function: NAALADase-like activity unknown. Has no NAAG hydrolyzing activity. Exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC (By similarity) |
Genomic Location for NAALADL1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the NAALADL1 gene 
Entrez Gene cytogenetic band: 11q12 Ensembl cytogenetic band: 11q13.1 HGNC cytogenetic band: 11q12NAALADL1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M064569:
(about GC identifiers)
Start:
|
64,568,871 bp from pter |
End:
|
64,582,585 bp from pter |
Size:
|
13,715 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000011.8 NT_033903.7
| Proteins for NAALADL1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: NALDL_HUMAN, Q9UQQ1 (See
protein sequence)Recommended Name: N-acetylated-alpha-linked acidic dipeptidase-like protein Size: 740 amino acids; 80622 Da
Cofactor: Binds 2 zinc ions per subunit (By similarity)
Subcellular location: Apical cell membrane; Single-pass type II membrane protein. Note=Ileal brush border membrane
Secondary accessions: O43176Alternative splicing: 8 isoforms: Q9UQQ1-1 Q9UQQ1-2 Q9UQQ1-3 Q9UQQ1-4 Q9UQQ1-5 Q9UQQ1-6 Q9UQQ1-7 Q9UQQ1-8 Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_005459.2
ENSEMBL proteins: ENSP00000340111 ENSP00000347530 ENSP00000344244 ENSP00000351484 ENSP00000347955 ENSP00000349045
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for NAALADL1: Assays for NAALADL1: | Protein
Domains/ Families for NAALADL1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9UQQ1
ProtoNet protein and cluster: Q9UQQ1 3 Blocks protein families: IPB003137 Protease-associated PA IPB007365 Transferrin receptor-like dimerisation domain IPB007484 Peptidase family M28
UniProtKB/Swiss-Prot: NALDL_HUMAN, Q9UQQ1Similarity: Belongs to the peptidase M28 family. M28B subfamily | Gene Function for NAALADL1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005468
Applied Biosystems Silencer® siRNAs for NAALADL1
Sigma-Aldrich siRNA and siRNA Panels for NAALADL1  Sigma-Aldrich shRNA for NAALADL1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005468                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005468                                  untagged cDNA clone in CMV expression vector: NM_005468 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_005468
UniProtKB/Swiss-Prot: NALDL_HUMAN, Q9UQQ1Function: NAALADase-like activity unknown. Has no NAAG hydrolyzing activity. Exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC (By similarity)Catalytic activity: Release of an unsubstituted, C-terminal glutamyl residue, typically from Ac-Asp-Glu or folylpoly-gamma-glutamatesEnzyme Number (IUBMB): EC 3.4.17.21 5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6
): About this table | Pathways & Interactions for NAALADL1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 1 Sigma-Aldrich "Your Favorite Gene" Pathway for NAALADL1 (Your Favorite Gene powered by Ingenuity) 
1 Interacting protein for NAALADL1 (ENSP000003442443) via UniProtKB, MINT, and/or STRINGAbout this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006508 | proteolysis |
IEA | -- | About this table
|
Drugs & Compounds for NAALADL1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for NAALADL1
|
Transcripts for NAALADL1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005468
Sigma-Aldrich siRNA and siRNA Panels for NAALADL1  Sigma-Aldrich shRNA for NAALADL1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_005468 REFSEQ mRNAs for NAALADL1 gene: NM_005468.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_005468               OriGene GFP tagged cDNA clone in CMV expression vector: NM_005468                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005468                                  untagged cDNA clone in CMV expression vector: NM_005468  Additional cDNA sequence: AF001547.1 AF010141.1 AJ012371.1 AK309536.1 AK311090.1 BC143643.1 BC143644.1 7 DOTS entries: DT.401313 DT.120710133 DT.99972116 DT.40131683 DT.95154328 DT.95342236 DT.120710109 24/49 AceView cDNA sequences (see all 49
):BU743082 CD514468 BP379466 BM726624 AI783670 AA504367 BX099491 AW170591 AI285158 AI244986 CB048466 BG757994 BU741137 AJ012371 BQ723610 AI868903 BP381256 BM682839 BF056631 BM719523 BM681269 AW135808 NM_005468 BF508363
highest scoring ESTs for NAALADL1:AJ012371 AF010141 AU098853 NM_005468 AA504367 AF001547 AI783670 AW024446 AW183158 BF111279 Unigene Cluster for NAALADL1: N-acetylated alpha-linked acidic dipeptidase-like 1 Hs.13967 [show with all ESTs]Unigene Representative Sequence: NM_005468
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for NAALADL1 (see all 10
)
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | · | 9d | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | · | 12c | ^ | 13 | ^ | 14a | · | 14b | ^ | 15a | · | 15b | · | 15c | ^ | 16a | · | 16b | · | 16c | ^ | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | - |   | - |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   |
| ExUns: | 17 | ^ | 18a | · | 18b | · | 18c | |
| SP1: | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for NAALADL1
6 Ensembl transcripts including schematic representations: ENST00000339885
ENST00000355369
ENST00000340252
ENST00000358658
ENST00000355721
ENST00000356632
|
Expression for NAALADL1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| NAALADL1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for NAALADL1
1 / 2 / 3 6 probe-sets matching NAALADL1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: CTGTGTATCC
SOURCE GeneReport for Unigene cluster: Hs.13967
Expression variation in blood from EXPOLDB for NAALADL1 UniProtKB/Swiss-Prot: NALDL_HUMAN, Q9UQQ1Tissue specificity: Mainly expressed in the distal small intestine. Also expressed in the spleen and testis. Weak expression in the brain, locating mainly to the brain stem, amygdala, thalamus and ventral striatum. Isoforms 2 and 3 are found in the small intestine and colon |
Orthologs for NAALADL1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for NAALADL1 gene from 5/7 species (see all 7
)
About this table Species with no ortholog for NAALADL1
ENSEMBL Gene Tree for NAALADL1 | Paralogs for NAALADL1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for NAALADL1 gene
- FOLH12 ENSG000001346122 NAALAD22
|
SNPs/Variants for NAALADL1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for NAALADL1 (up to first 250kb)
|
Disorders & Mutations for NAALADL1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 602640
|
Medical News for NAALADL1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for NAALADL1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 3 PubMed articles for NAALADL1 gene: |
Search for NAALADL1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing NAALADL1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing NAALADL1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NAALADL1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for NAALADL1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for NAALADL1:

|
GeneCards Homepage - Last full update: 1 Jul 2009
Incremental update: 13 Oct 2009
|