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GRAP2 Gene

protein-coding GIFtS: 65

GC22P038621

GRB2-related adaptor protein 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
GADS ^¹, ², ³
GRAP-2 ^²
GRB2L ^², ³
GRBLG ^¹, ², ³
GRBX ^³
GRID ^², ³, ⁵
GRPL ^²
GrbX ^¹, ²
Grf-40 ^³
Grf40 ^¹, ²
Mona ^¹, ²
OTTHUMP00000028837 ^²
P38 ^², ³

Descriptions
Adapter protein GRID ^³
GRB-2-like protein ^², ³
GRB2-related adaptor protein 2 ^²
GRB2-related protein with insert domain ^²
Grf40 adapter protein ^³
Growth factor receptor-binding protein ^², ³
Hematopoietic cell-associated adapter protein GrpL ^³
Protein GADS ^³
SH3-SH2-SH3 adapter Mona ^³
SH3-SH2-SH3 adaptor molecule ^²
growth factor receptor-bound protein 2-related adaptor protein 2 ^²
hematopoietic cell-associated adaptor protein GRPL ^²

External Ids
HGNC: 4563¹
Entrez Gene: 9402²
UniProtKB: O75791³
Ensembl: ENSG00000100351⁷

Search outside databases for aliases for GRAP2 gene

Previous GC identifers: GC22P036911 GC22P038540

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for GRAP2:

This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein

involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member,

GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3

domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1

(GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Transcript variants

utilizing alternative polyA sites exist. [provided by RefSeq]

UniProtKB/Swiss-Prot: GRAP2_HUMAN, O75791

Function: Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc

Gene Wiki entry for GRAP2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the GRAP2 gene

Entrez Gene cytogenetic band: 22q13.2 Ensembl cytogenetic band: 22q13.1 HGNC cytogenetic band: 22q13.2

GRAP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22P038621: (about GC identifiers)

Start:	38,627,032 bp from pter
End:	38,698,204 bp from pter
Size:	71,173 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000022.9 NT_011520.11

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: GRAP2_HUMAN, O75791 (See protein sequence)

Recommended Name: GRB2-related adapter protein 2

Size: 330 amino acids; 37909 Da

Subunit: Interacts with phosphorylated LIME1 upon TCR activation (By similarity). Interacts with

phosphorylated LAT and LAX1 upon TCR activation. Interacts with SHB

Secondary accessions: O43726 Q9NRB7

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_004801.1

ENSEMBL proteins:

ENSP00000385607 ENSP00000339186

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (GRAP2)
	Human Recombinant Proteins from Abnova (GRAP2)

OriGene Purified Recombinant Human Protein: GRAP2

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	18029348
GO:0005730	NOT nucleolus	IDA	18029348
GO:0005737	cytoplasm	TAS	9878555
GO:0005829	cytosol	EXP	11048639 11607830 17652306

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Antibodies for GRAP2:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of GRAP2
	Sigma-Aldrich Antibodies for GRAP2
	R&D Systems Antibodies for GRAP2
	Antibodies from Abcam (GRAP2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (GRAP2)
	Novus Biologicals Antibodies for GRAP2

Assays for GRAP2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry O75791

ProtoNet protein and cluster: O75791

2 Blocks protein families:

IPB000980 SH2 domain signature

IPB001452 SH3 domain signature

UniProtKB/Swiss-Prot: GRAP2_HUMAN, O75791

Similarity: Belongs to the GRB2/sem-5/DRK family

Similarity: Contains 1 SH2 domain

Similarity: Contains 2 SH3 domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GRAP2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GRAP2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004810

Applied Biosystems Silencer® siRNAs for GRAP2

Sigma-Aldrich siRNA for GRAP2

Sigma-Aldrich shRNA for GRAP2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for GRAP2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_004810
Myc/DDK tagged cDNA clone in CMV expression vector: NM_004810
untagged cDNA clone in CMV expression vector: NM_004810

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004810

UniProtKB/Swiss-Prot: GRAP2_HUMAN, O75791

Function: Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc

Genatlas biochemistry entry for GRAP2:

Grb2-related adaptor protein 2,expressed in thymus and spleen interacting with cKIT,EPOR,coupling

tyrosine kinase to the RAS pathway

2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Grap2):

hematopoietic system

immune system

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005070	SH3/SH2 adaptor activity	TAS	9878555
GO:0005515	protein binding	IPI	12359715

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5 Sigma-Aldrich "Your Favorite Gene" Pathways for GRAP2 (Your Favorite Gene powered by Ingenuity)

Fc Epsilon RI Signaling
iCOS-iCOSL Signaling in T Helper Cells
CTLA4 Signaling in Cytotoxic T Lymphocytes
T Cell Receptor Signaling
CD28 Signaling in T Helper Cells

GeneDecks GRAP2 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for GRAP2

5/57 Interacting proteins for GRAP2 (O75791² ENSP00000339186³) via UniProtKB, MINT, and/or STRING (see all 57 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
LCP2	Q13094², ENSP00000046794³	MINT-4302429 MINT-4302374 MINT-4302356 MINT-4302410 MINT-4302332 MINT-7041321 MINT-4302284 MINT-4302391 STRING (score=.999)
GAB1	Q13480², ENSP00000262995³	MINT-58403 STRING (score=.894)
ERBB2	P04626²	MINT-74540
MAP4K1	ENSP00000221409³	STRING (score=.997)
CCNDBP1	ENSP00000300213³	STRING (score=.992)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007265	Ras protein signal transduction	TAS	9878555
GO:0007267	cell-cell signaling	TAS	9878555

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for GRAP2
4 Novoseek chemical compound relationships for GRAP2 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	61.04	22	15029250 (2), 12186560 (2), 16493040 (2), 15735648 (2) (see all 12)
phosphotyrosine	53.01	1	12356870 (1)
lipid	0.00	1	12356870 (1)
calcium	0.00	1	12356870 (1)

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GRAP2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GRAP2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004810

Sigma-Aldrich siRNA for GRAP2

Sigma-Aldrich shRNA for GRAP2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004810

REFSEQ mRNAs for GRAP2 gene:

NM_004810.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004810

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004810
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_004810
                                 untagged cDNA clone in CMV expression vector: NM_004810

Additional cDNA sequence:

AF042380.1 AF090456.1 AF102694.1 AF121002.1 AF129476.1 AF236119.1 AF236120.1 AJ011736.1

AK303280.1 AK303332.1 AK303470.1 AK303512.1 AK303657.1 AK312830.1 AY069959.1 BC025692.1

BC026002.1 CR456498.1 CR536524.1 CR541849.1 CR598431.1 CR604186.1 CR607150.1 Y18051.1

9 DOTS entries:

DT.433702 DT.95171199 DT.100017167 DT.87015062 DT.100670611 DT.407834 DT.120671271 DT.120671280

DT.97777471

24/75 AceView cDNA sequences (see all 75 ):

CR456498 NM_004810 CR604186 AI248165 AF042380 BC025692 AF236120 AA669142

AF090456 CR536524 N57907 CR607150 H55177 CR598431 BX437694 BX387888

AF102694 BI772011 R02185 CD619360 AF236119 BC026002 BI912538 AW024274

highest scoring ESTs for GRAP2:

AJ011736 AF042380 AF090456 AF102694 AF121002 AF129476 AF236119 AF236120 AI277343 AI291777

Unigene Cluster for GRAP2:

GRB2-related adaptor protein 2

Hs.517499 [show with all ESTs]

Unigene Representative Sequence: CR604186

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for GRAP2

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4a	·	4b	^	5
SP1:
SP2:					-

About this scheme

ECgene alternative splicing isoforms for GRAP2

2 Ensembl transcripts including schematic representations:

ENST00000407075 ENST00000344138

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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GRAP2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for GRAP2

¹ / ² / ³

5 probe-sets matching GRAP2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
38867_g_at²^{, 3}	U95-A	1	1.00	1.00	0.96	0.53	Z82206	0.20	1.00	0.72	1
38865_at²^{, 3}	U95-A	1	1.00	1.00	0.88	1.77	AJ011736	1.00	1.00	1.00	1
38866_at²^{, 3}	U95-A	1	1.00	1.00	0.96	0.89	Z82206	0.20	1.00	0.72	1
208406_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_004810	0.60	1.00	0.82	1
208406_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks GRAP2 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ACTATATATA

SOURCE GeneReport for Unigene cluster: Hs.517499

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for GRAP2 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	GRAP2¹	--	GRB2-related adaptor protein 2	90.05(n) 93.97(a)	481241 XM_844613.1 XP_849706.1
chimpanzee (Pan troglodytes)	GRAP2¹	--	GRB2-related adaptor protein 2	99.39(n) 99.7(a)	744653 XM_001166390.1 XP_001166390.1
cow (Bos taurus)	GRAP2¹	--	GRB2-related adaptor protein 2	86.81(n) 88.29(a)	522346 XM_600626.3 XP_600626.2
rat (Rattus norvegicus)	Grap2¹	--	GRB2-related adaptor protein 2	84.93(n) 87(a)	366962 NM_001034944.1 NP_001030116.1
mouse (Mus musculus)	Grap2^{1, 5}	15⁵	GRB2-related adaptor protein 2^{1, 5}	84.16(n)¹ 88.2(a)¹	17444¹ NM_010815.2¹ NP_034945.1¹ AF053405⁵ AF055465⁵ (see all 13)

About this table Species with no ortholog for GRAP2

ENSEMBL Gene Tree for GRAP2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for GRAP2 gene

GRB2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/339 NCBI SNPs in GRAP2 are shown (see all 339 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 128)

AB	SNP ID	Valid	Chr 22 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs137959^1,2	A,C,F,H,O	38626324(+)	`TAGCAA/GTGTCT`	1	--	ng5¹		13	MN NA EU EA WA	1334
	rs9611236^1,2	H	38697827(+)	`ATTCCG/ATAAAG`	1	--	ng3¹ ese³		4	EU EA WA	420
	rs6001703^1,2	H	38625232(+)	`AATTAG/ACTTCC`	1	--	ng5¹		4	EU EA WA	420
	rs12759^1,2	H	38696996(+)	`TGGGCC/TTCTTC`	1	L/F	mis¹ ese³ trp³		5	MN EU EA WA	590
	rs5757821^1,2	H	38695471(+)	`CAGCTC/GCAGGC`	1	L/L	syn¹ ese³		4	EU EA WA	418
	rs739091^1,2	A,C,F,H,O	38647072(+)	`TCAGGC/ACTCCA`	1	--	int¹		16	EA MN EU WA NA	2994
	rs137975^1,2	A,C,F,H,O	38647573(+)	`ttttgC/Tagtaa`	1	--	int¹		20	EA NA EU WA	2782
	rs107140^1,2	A,C,F,H,O	38664873(+)	`CGGACA/GAGCTG`	1	--	int¹		17	EU EA WA NA	2916
	rs470084^1,2	A,C,F,H,O	38643302(+)	`TGAAAC/TTCCAG`	1	--	int¹		9	CSA NA EU EA WA	780
	rs137970^1,2	A,C,F,H,O	38639802(+)	`TCACAA/GCTTCT`	1	--	int¹		11	EU EA WA NA	920

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HapMap Linkage Disequilibrium images for GRAP2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 604518

2 Novoseek disease relationships for GRAP2 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	0.00	2	9831174 (1)
tumors	0.00	4	19027225 (1), 9831174 (1)

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Genetic Association Database: GRAP2
Human Genome Epidemiology Navigator: GRAP2 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/72 PubMed articles for GRAP2 gene (see all 72 ):

Molecular cloning and expression of human grap-2, a novel leukocyte- specific SH2- and SH3-containing adaptor-like protein that binds to gab-1. (PubMed id 9878555)^{1, 2, 3, 4} Qiu M....Liu M. (1998)
Grf40, A novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LAT. (PubMed id 10224278)^{2, 3, 4} Asada H....Sugamura K. (1999)
Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling. (PubMed id 10811803)^{1, 3, 4} Zhang W.... Samelson L.E. (2000)
Genetic variations in humans associated with differences in the course of hepatitis C. (PubMed id 15063762)^{3, 6} Saito T....Kawata S. (2004)
A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)^{3, 4} Collins J.E.... Dunham I. (2004)
Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)^{3, 4} Brill L.M....Peters E.C. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry. (PubMed id 12522270)^{3, 4} Salomon A.R.... Peters E.C. (2003)
Genomic organization and restricted expression of the human Mona/Gads gene suggests regulation by two specific promoters. (PubMed id 12062812)^{3, 4} Guyot B.... Mouchiroud G. (2002)
Molecular cloning of a novel gene encoding a membrane-associated adaptor protein (LAX) in lymphocyte signaling. (PubMed id 12359715)^{3, 4} Zhu M.... Zhang W. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 9402	HGNC: 4563	AceView: GRAP2	Ensembl:ENSG00000100351	euGenes: HUgn9402
ECgene: GRAP2	H-InvDB: GRAP2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for GRAP2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for GRAP2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for GRAP2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for GRAP2		Antibodies for GRAP2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for GRAP2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Custom Service for Rabbit Pab from Full-length Protein

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	Purified proteins from HEK293T cells
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	shRNA in GFP-retroviral vector

Search Tocris compounds for GRAP2

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GRAP2 Gene at Home site.
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p595elmp1

GRAP2 Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for GRAP2

Summaries
for GRAP2

Genomic Location
for GRAP2

Proteins
for GRAP2

Protein Domains/
Families
for GRAP2

Gene Function
for GRAP2

Pathways & Interactions
for GRAP2

Drugs & Compounds
for GRAP2

Transcripts
for GRAP2

Expression
for GRAP2

Orthologs
for GRAP2

Paralogs
for GRAP2

SNPs/Variants
for GRAP2

Disorders & Mutations
for GRAP2

Medical News
for GRAP2

Publications
for GRAP2

Search for GRAP2

Genome Databases showing GRAP2

Other Databases showing GRAP2

Specialized Databases showing GRAP2

Licensable Technologies
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Services
for GRAP2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

GRAP2 (Gene Symbol)
GADS
GRAP-2
GRB2L
GRBLG
GRBX
GRID
GRPL
GrbX
Grf-40
Grf40
Mona
OTTHUMP00000028837
P38
Adapter protein GRID
GRB-2-like protein
GRB2-related adaptor protein 2
GRB2-related protein with insert domain
Grf40 adapter protein
Growth factor receptor-binding protein
Hematopoietic cell-associated adapter protein GrpL
Protein GADS
SH3-SH2-SH3 adapter Mona
SH3-SH2-SH3 adaptor molecule
growth factor receptor-bound protein 2-related adaptor protein 2
hematopoietic cell-associated adaptor protein GRPL

GRAP2 Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor GRAP2

Summariesfor GRAP2

Genomic Locationfor GRAP2

Proteinsfor GRAP2

Protein Domains/Familiesfor GRAP2

Gene Functionfor GRAP2

Pathways & Interactionsfor GRAP2

Drugs & Compoundsfor GRAP2

Transcriptsfor GRAP2

Expression for GRAP2

Orthologsfor GRAP2

Paralogsfor GRAP2

SNPs/Variantsfor GRAP2

Disorders & Mutationsfor GRAP2

Medical Newsfor GRAP2

Publicationsfor GRAP2

Search for GRAP2

Genome Databases showing GRAP2

Other Databases showing GRAP2

Specialized Databases showing GRAP2

Licensable Technologiesfor GRAP2

Servicesfor GRAP2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for GRAP2

Summaries
for GRAP2

Genomic Location
for GRAP2

Proteins
for GRAP2

Protein Domains/
Families
for GRAP2

Gene Function
for GRAP2

Pathways & Interactions
for GRAP2

Drugs & Compounds
for GRAP2

Transcripts
for GRAP2

Expression
for GRAP2

Orthologs
for GRAP2

Paralogs
for GRAP2

SNPs/Variants
for GRAP2

Disorders & Mutations
for GRAP2

Medical News
for GRAP2

Publications
for GRAP2

Licensable Technologies
for GRAP2

Services
for GRAP2