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FABP5 Gene

protein-coding   GIFtS: 59

GC08P082355
fatty acid binding protein 5 (psoriasis-associated)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
E-FABP 1, 2, 3
EFABP 2, 5
PA-FABP 1, 2, 3
PAFABP 2, 5
Descriptions
Fatty acid-binding protein 5 3
Psoriasis-associated fatty acid-binding protein homolog 3
fatty acid binding protein 5 (psoriasis-associated) 2
External Ids
HGNC: 35601
Entrez Gene: 21712
UniProtKB: Q014693
Ensembl: ENSG000001646877
Search outside databases for aliases for FABP5 gene

Previous GC identifers: GC08P081070 GC08P082241 GC08P081915 GC08P082242

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for FABP5:
This gene encodes the fatty acid binding protein found in epidermal cells, and was first identified
as being upregulated in psoriasis tissue. Fatty acid binding proteins are a family of small,
highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic
ligands. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. The
human genome contains many pseudogenes similar to this locus. [provided by RefSeq]

UniProtKB/Swiss-Prot: FABP5_HUMAN, Q01469
Function: High specificity for fatty acids. Highest affinity for C18 chain length. Decreasing the
chain length or introducing double bonds reduces the affinity. May be involved in keratinocyte
differentiation

Gene Wiki entry for FABP5

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the FABP5 gene  

Entrez Gene cytogenetic band: 8q21.13   Ensembl cytogenetic band:  8q21.13   HGNC cytogenetic band: 8q21.13

FABP5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P082355:     (about GC identifiers)

Start:
82,355,326 bp from pter
End:
82,359,567 bp from pter
Size:
4,242 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000008.9  NT_008183.18  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: FABP5_HUMAN, Q01469 (See protein sequence)
Recommended Name: Fatty acid-binding protein, epidermal  
Size: 135 amino acids; 15164 Da
Subcellular location: Cytoplasm
PDB structure from and Proteopedia :
1B56 (3D)    1JJJ (3D)    

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_001435.1  

    ENSEMBL proteins: 
    ENSP00000379647 ENSP00000297258 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (Fatty Acid Binding Protein 5)
    Human Recombinant Proteins from Abnova (FABP5)
                  OriGene Purified Recombinant Human Protein: FABP5 

    1 Gene Ontology (GO) cellular component term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737 cytoplasm TAS16130169
    About this table

    Antibodies for FABP5: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for FABP5
    R&D Systems Antibodies for FABP5
    Antibodies from Abcam (Fatty Acid Binding Protein 5), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (FABP5)
    Novus Biologicals Antibodies for FABP5

    Assays for FABP5: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    3 InterPro domains/families:
     IPR012674 Calycin
     IPR000463 Fatty_acid_bd
     IPR000566 Lipocln_cytFABP


       GeneDecks  FABP5 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q01469

    ProtoNet protein and cluster: Q01469

    1 Blocks protein family: IPB000463 Cytosolic fatty-acid binding protein

    UniProtKB/Swiss-Prot: FABP5_HUMAN, Q01469
    Domain: Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior
    Similarity: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Browse Invitrogen for RNAi
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (FABP5)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001444

                  Applied Biosystems Silencer® siRNAs for FABP5

                  Sigma-Aldrich siRNA for FABP5  
                         Sigma-Aldrich shRNA for FABP5  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for FABP5
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_001444
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_001444
                                     untagged cDNA clone in CMV expression vector: NM_001444 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_001444

    UniProtKB/Swiss-Prot: FABP5_HUMAN, Q01469
    Function: High specificity for fatty acids. Highest affinity for C18 chain length. Decreasing the
    chain length or introducing double bonds reduces the affinity. May be involved in keratinocyte
    differentiation

    9 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Fabp5):

    adipose tissuegrowth/sizehomeostasis/metabolismimmune system
    life span-post-weaning/agingliver/biliary systemmuscleskin/coat/nails

    3 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215 transporter activity IEA--
    GO:0005504 fatty acid binding TAS8092987
    GO:0005515 protein binding IPI12839573
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    1 Sigma-Aldrich "Your Favorite Gene" Pathway for  FABP5  (Your Favorite Gene powered by Ingenuity) 
     LPS/IL-1 Mediated Inhibition of RXR Function

       GeneDecks  FABP5 for the pathways selected above  
    About GeneDecksing

    1 Kegg Pathway  (Kegg details for FABP5):
     hsa03320 PPAR signaling pathway

       GeneDecks  FABP5 for the pathways selected above  
    About GeneDecksing
     Gene Network CentralTM Interacting Genes and Proteins Network for  FABP5 


    5/19 Interacting proteins for FABP5 (ENSP000002972583 Q014691) via UniProtKB, MINT, and/or STRING (see all 19 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AURKAO149651EBI-1054073, EBI-448680
    FABP6ENSP000003122833STRING (score=.934)
    CACNA2D1ENSP000003493203STRING (score=.899)
    CBLENSP000002640333STRING (score=.899)
    DIO3ENSP000003522733STRING (score=.899)
    About this table

    3 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006629 lipid metabolic process TAS8092987
    GO:0006810 transport IEA--
    GO:0008544 epidermis development TAS1512466
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Sigma-Aldrich Small Molecules for FABP5:
    Antagonist

    Browse Tocris compounds for FABP5
    7 Novoseek chemical compound relationships for FABP5 gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    fatty acid 73.56 77 12839573 (6), 10191275 (3), 8092987 (3), 17066326 (2) (see all 33)
    oleic acid 32.32 1 8427590 (1)
    lipid 2.31 4 8726632 (1), 17066326 (1)
    arachidonic acid 0.99 3 15342681 (3)
    cholesterol 0.00 1 8092987 (1)
    steroid 0.00 3 9059669 (2)
    calcium 0.00 3 12839573 (2), 7881766 (1)
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Browse Invitrogen for RNAi
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (FABP5)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001444

                  Sigma-Aldrich siRNA for FABP5  
                         Sigma-Aldrich shRNA for FABP5  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001444  

    REFSEQ mRNAs for FABP5 gene: 

    NM_001444.1   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001444  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_001444
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_001444
                                     untagged cDNA clone in CMV expression vector: NM_001444 

    Additional cDNA sequence: 

    AK226036.1 AK311856.1 BC019385.2 BC070303.1 BT007449.1 M94856.1 

    15 DOTS entries:

    DT.97802928  DT.454265  DT.99987236  DT.40106155  DT.92441159  DT.91996889  DT.120636050  DT.95139161 
    DT.40106154  DT.95139191  DT.92347605  DT.95085635  DT.95139189  DT.92441155  DT.97857218 

    24/199 AceView cDNA sequences (see all 199 ):

    AA595972 AA082685 BM712171 BM314523 AI190490 CB124107 AA385920 AI143574 
    CD677981 CK821302 AW805732 BX477417 BE772746 AW805859 AA300671 BC019385 
    BM789868 BE467034 BF726770 BG678687 AI685547 BQ446473 AA315585 AA815251 

    highest scoring ESTs for FABP5:

    M94856 AA101190 AA316680 AA393514 AA542821 AA584053 AA661928 AA815251 AA888264 AA888427 

    Unigene Cluster for FABP5:

    Fatty acid binding protein 5 (psoriasis-associated)
    Hs.408061  [show with all ESTs]
    Unigene Representative Sequence: BM563703


    GeneLoc Exon Structure

    2 Ensembl transcripts including schematic representations:
    ENST00000396359  ENST00000297258  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    FABP5 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for FABP5

    1 / 2 / 3

    3 probe-sets matching FABP5 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    39799_at2, 3 U95-A 12 0.56 0.23 1.00 1.00 M94856 1.00 0.87 0.94 1

    202345_s_at2, 3 U133-A 12 1.00 0.14 -- -- NM_001444 0.60 1.00 0.82 1

    202345_s_at2 U133Plus2 12 1.00 0.14 -- -- -- -- -- -- --
    GeneDecks  FABP5 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: CAGCTATTTC

    SOURCE GeneReport for Unigene cluster: Hs.408061

    Expression variation in blood from EXPOLDB for FABP5

    UniProtKB/Swiss-Prot: FABP5_HUMAN, Q01469
    Tissue specificity: Keratinocytes; highly expressed in psoriatic skin

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for FABP5 gene from 5 species
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    LOC6095541   -- similar to Fatty acid-binding protein, epidermal (E-FABP) more 92.52(n)
    94.9(a)
    609554  XM_847705.1  XP_852798.1 
    chimpanzee
    (Pan troglodytes)
    LOC4701301   -- similar to fatty acid binding protein homologue 96.79(n)
    94.07(a)
    470130  XM_525514.2  XP_525514.1 
    cow
    (Bos taurus)
    FABP51   -- fatty acid binding protein 5 90.37(n)
    91.85(a)
    281760  NM_174315.3  NP_776740.1 
    mouse
    (Mus musculus)
    Fabp55 3 fatty acid binding protein 5, epidermal   -- X70100 
    chicken
    (Gallus gallus)
    FABP51   -- fatty acid binding protein 5 69.6(n)
    64.8(a)
    420197  NM_001006346.1  NP_001006346.1 
    About this table        Species with no ortholog for FABP5

    ENSEMBL Gene Tree for FABP5
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for FABP5 gene
    FABP5L71  FABP32  FABP72  

    Pseudogenes
    9 related pseudogenes


    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    4 NCBI SNPs in FABP5 are shown
    (Click for Applied Biosystems TaqMan ® Genotyping Assay) (only AB snps)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 8 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    --
    rs736945271,2
    --82353699(+) CATTTA/TAAAAT 1 -- ng510--------
    --
    rs58927571,2
    --82353461(+) CCATG-/CCCTTT 1 -- ng510--------
    --
    rs100982881,2
    --82359513(+) GTGTGG/TTGGAT 1 -- ut310--------
    rs31808831,2
    --82359279(+) TAACTC/TTTTTA 1 -- int11Minor allele frequency- T:0.00MN 184
    About this table
    The following additional 32 SNP(s) have been found in Applied Biosystems data source:
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)


     rs391842 rs7829015 rs482745 rs202276 rs2195051 rs437831 rs7829587
     rs13271396 rs414930 rs4535702 rs800175 rs7829684 rs202280 rs7844898
     rs202275 rs408070 rs7829738 rs7829504 rs800174 rs7844746 rs7844481
     rs7463736 rs202281 rs7813105 rs202278 rs454550 rs1062115 rs12549270
     rs7814556 rs6997023 rs800176 rs550567

    HapMap Linkage Disequilibrium images for FABP5 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 605168

    10 Novoseek disease relationships for FABP5 gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    psoriasis 50.91 7 8726632 (2), 12839573 (1), 8427590 (1), 12804984 (1) (see all 6)
    carcinoma squamous cell 30.44 8 8726632 (3), 8824783 (1), 9438903 (1), 15922867 (1) (see all 5)
    breast cancer 9.50 12 18359695 (2), 16471039 (1)
    skin diseases 8.30 2 8726632 (1), 10331666 (1)
    shock 0.00 2 16115757 (1), 19294697 (1)
    cancer 0.00 1 12459653 (1)
    obesity 0.00 5 17359244 (2), 17472010 (1)
    carcinoma 0.00 2 15922867 (1), 17428383 (1)
    tumors 0.00 6 9307301 (2), 18359695 (2), 19337991 (2)
    metastasis 0.00 3 18360704 (1), 12459653 (1)
    About this table

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/82 PubMed articles for FABP5 gene (see all 82 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 2171 HGNC: 3560 AceView: FABP5 Ensembl:ENSG00000164687 euGenes: HUgn2171
    ECgene: FABP5 H-InvDB: FABP5
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for FABP5:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
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     Predesigned and custom siRNAs for FABP5 Antibodies for FABP5
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for FABP5 Small molecules for FABP5
     "Your Favorite Gene" Pathwaysfeedback


      
     Antibodies   Primer Pairs  
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     Recombinant & Natural Proteins  

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     Custom Service for Mouse Mab
     Custom Service for Rabbit Pab from Full-length Protein
      
     Search for Antibodies & Assays

     Recombinant Proteins
    (Fatty Acid Binding Protein 5)
     Antibodies (Fatty Acid Binding Protein 5)
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     Search Tocris compounds for FABP5




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for FABP5

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