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Aliases & Descriptions for FABP2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| FABPI 2, 3 | | I-FABP 1, 2, 3 | | MGC133132 2 |
| | | Descriptions |
|---|
| fatty acid binding protein 2, intestinal 2 | | intestinal fatty acid binding protein 2 2 |
|
| | Search outside databases for aliases for FABP2 genePrevious GC identifers: GC04M120996 GC04M120631 GC04M120697 GC04M120596 |
Summaries for FABP2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for FABP2: The intracellular fatty acid-binding proteins (FABPs) belong to a multigene family with nearly twenty identified members. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Intestinal fatty acid-binding protein 2 gene contains four exons and is an abundant cytosolic protein in small intestine epithelial cells. This gene has a polymorphism at codon 54 that identified an alanine-encoding allele and a threonine-encoding allele. Thr-54 protein is associated with increased fat oxidation and insulin resistance. [provided by RefSeq] UniProtKB/Swiss-Prot: FABPI_HUMAN, P12104Function: FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensorGene Wiki entry for FABP2 |
Genomic Location for FABP2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the FABP2 gene 
Entrez Gene cytogenetic band: 4q28-q31 Ensembl cytogenetic band: 4q26 HGNC cytogenetic band: 4q28-q31FABP2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M120518:
(about GC identifiers)
Start:
|
120,457,853 bp from pter |
End:
|
120,462,766 bp from pter |
Size:
|
4,914 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000004.10 NT_016354.18
| Proteins for FABP2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: FABPI_HUMAN, P12104 (See
protein sequence)Recommended Name: Fatty acid-binding protein, intestinal Size: 132 amino acids; 15207 Da
Subcellular location: Cytoplasm
PDB structures from and Proteopedia :1KZW (3D)
 1KZX (3D)
 3IFB (3D)
 
Secondary accessions: Q2NKJ1REFSEQ proteins: NP_000125.2
ENSEMBL proteins: ENSP00000274024
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: FABP2 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- | About this table
Antibodies for FABP2: Assays for FABP2: | Protein
Domains/ Families for FABP2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P12104
ProtoNet protein and cluster: P12104 1 Blocks protein family: IPB000463 Cytosolic fatty-acid binding protein
UniProtKB/Swiss-Prot: FABPI_HUMAN, P12104Domain: Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interiorSimilarity: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family | Gene Function for FABP2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000134
Applied Biosystems Silencer® siRNAs for FABP2
Sigma-Aldrich siRNA for FABP2  Sigma-Aldrich shRNA for FABP2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000134                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_000134                                  untagged cDNA clone in CMV expression vector: NM_000134 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_000134
UniProtKB/Swiss-Prot: FABPI_HUMAN, P12104Function: FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensorInduction: By EGFGenatlas biochemistry entry for FABP2:fatty acid binding protein 2,intestinal5 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Fabp2):
2 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for FABP2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 2 Sigma-Aldrich "Your Favorite Gene" Pathways for FABP2 (Your Favorite Gene powered by Ingenuity) 
Gene Network CentralTM Interacting Genes and Proteins Network for FABP2 
5/23 Interacting proteins for FABP2 (ENSP000002740243) via UniProtKB, MINT, and/or STRING (see all 23
)About this table
2 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for FABP2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|  | Sigma-Aldrich Small Molecules for FABP2: Antagonist |
Browse Tocris compounds for FABP2 10/22 Novoseek chemical compound relationships for FABP2 gene (see all 22
)
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| fatty acid |
87.08 |
479 |
10627505 (6), 9516437 (5), 18235139 (5), 15722357 (4) (see all 99) |
| acrylodan |
74.21 |
11 |
9199809 (3), 10331662 (1), 8626681 (1), 8422363 (1) (see all 5) |
| oleic acid |
63.78 |
12 |
8652536 (2), 12809510 (2), 19309727 (1), 9931262 (1) (see all 8) |
| lipid |
54.71 |
57 |
12370850 (3), 12634920 (3), 16297872 (2), 12809489 (2) (see all 32) |
| clostripain |
54.30 |
3 |
16229473 (1), 12809510 (1) |
| threonine |
51.21 |
33 |
10229304 (2), 11124746 (2), 9179548 (2), 16013194 (1) (see all 16) |
| triacylglycerol |
45.84 |
13 |
11876264 (3), 12646232 (2), 18065580 (2), 17209184 (1) (see all 5) |
| glucose |
43.10 |
27 |
11423496 (2), 16311100 (2), 9181478 (2), 7657027 (1) (see all 16) |
| cholesterol |
40.88 |
6 |
18235139 (2), 8218286 (1), 16718625 (1), 9181478 (1) (see all 5) |
| carboxylate |
37.24 |
3 |
9516437 (1), 12200543 (1) |
About this table
|
Transcripts for FABP2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000134
Sigma-Aldrich siRNA for FABP2  Sigma-Aldrich shRNA for FABP2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_000134 REFSEQ mRNAs for FABP2 gene: NM_000134.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_000134               OriGene GFP tagged cDNA clone in CMV expression vector: NM_000134                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_000134                                  untagged cDNA clone in CMV expression vector: NM_000134  Additional cDNA sequence: AK025079.1 BC069466.1 BC069617.1 BC069625.1 BC069637.1 BC111791.1 2 DOTS entries: DT.40194860 DT.91937785 13 AceView cDNA sequences:BC069466 BC069637 CF529938 BX280932 BQ010664 AK025079 BF002011 BF591167 BC069625 NM_000134 AW605378 BC069617 AA587057
highest scoring ESTs for FABP2:AK025079 AW605378 BC069466 BC069617 BC069625 BC069637 BX280932 BF002011 BF591167 BQ010664 Unigene Cluster for FABP2: Fatty acid binding protein 2, intestinal Hs.282265 [show with all ESTs]Unigene Representative Sequence: NM_000134
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000274024
|
Expression for FABP2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| FABP2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for FABP2
1 / 2 / 3 3 probe-sets matching FABP2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: CCAAAGCAAA
SOURCE GeneReport for Unigene cluster: Hs.282265
Expression variation in blood from EXPOLDB for FABP2 UniProtKB/Swiss-Prot: FABPI_HUMAN, P12104Tissue specificity: Expressed in the small intestine and at much lower levels in the large intestine. Highest expression levels in the jejunum |
Orthologs for FABP2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for FABP2 gene from 5/9 species (see all 9
)
About this table Species with no ortholog for FABP2
ENSEMBL Gene Tree for FABP2 | Paralogs for FABP2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for FABP2 gene
- RBP12 RBP22 RBP52 RBP72
|
SNPs/Variants for FABP2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for FABP2 (up to first 250kb)
|
Disorders & Mutations for FABP2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 134640
10/31 Novoseek disease relationships for FABP2 gene (see all 31
)
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| intestinal ischemia |
72.21 |
23 |
7797132 (3), 15120958 (2), 11592792 (1), 19279473 (1) (see all 11) |
| insulin resistance |
64.34 |
59 |
11299043 (3), 10337870 (3), 11422402 (3), 17211557 (3) (see all 27) |
| mesenteric infarction |
51.87 |
4 |
8566578 (4) |
| niddm |
50.68 |
22 |
9589253 (3), 19324445 (2), 15776585 (2), 10229304 (1) (see all 12) |
| hyperlipidemia familial combined |
50.04 |
2 |
9194752 (1), 12370850 (1) |
| insulin sensitivity |
48.74 |
22 |
18422024 (3), 16002819 (3), 17921407 (2), 11555846 (2) (see all 11) |
| necrosis bowel |
47.77 |
1 |
16971202 (1) |
| hypertriglyceridemia |
44.58 |
6 |
16908951 (1), 17684408 (1), 15547295 (1), 16919542 (1) (see all 5) |
| dyslipidemia |
41.65 |
9 |
11866034 (3), 12161503 (2), 9194752 (1), 10337870 (1) (see all 6) |
| hyperuricemia |
41.55 |
3 |
10337870 (1), 15135268 (1) |
About this table
Genatlas disease: FABP2 insulin resistance,increased fatty oxidation in Pima Indian population (FABP2 polymorphism,A94T) Human Gene Mutation Database: FABP2 Genetic Association Database: FABP2 Human Genome Epidemiology Navigator: FABP2 (75 documents)
|
Medical News for FABP2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for FABP2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/283 PubMed articles for FABP2 gene (see all 283
):- An amino acid substitution in the human intestinal fatty acid binding protein is associated with increased fatty acid binding, increased fat oxidation, and insulin resistance. (PubMed id 7883976)1, 3, 4, 6 Baier L.J.... Prochazka M. (1995)
- The association of Ala54Thr variant of intestinal fatty acid binding protein gene with general and regional adipose tissue depots. (PubMed id 12899384)3, 4, 6 Kunsan X....Rong Z. (1999)
- Solution structure of human intestinal fatty acid binding protein: implications for ligand entry and exit. (PubMed id 9204553)1, 3, 4 Zhang F.... Hamilton J.A. (1997)
- Intestinal-type and liver-type fatty acid-binding protein in the intestine. Tissue distribution and clinical utility. (PubMed id 14563446)1, 3, 4 Pelsers M.M.A.L.... Glatz J.F.C. (2003)
- Variation in the FABP2 promoter affects gene expression: implications for prior association studies. (PubMed id 14666368)1, 3, 6 Formanack M.L. and Baier L.J. (2004)
- Effects of intestinal fatty acid-binding protein gene Ala54Thr polymorphism and beta3-adrenergic receptor gene Trp64Arg polymorphism on insulin resistance and fasting plasma glucose in young to older Japanese men. (PubMed id 11699048)1, 3, 6 Ishii T....Saruta T. (2001)
- Codon 54 polymorphism of the fatty acid binding protein 2 gene is associated with increased fat oxidation and hyperinsulinemia, but not with intestinal fatty acid absorption in Korean men. (PubMed id 11288045)1, 3, 6 Kim C.H....Suh K.I. (2001)
- Thr54 allele of the FABP2 gene affects resting metabolic rate and visceral obesity. (PubMed id 15620432)1, 3, 6 Takakura Y....Yoshida T. (2005)
- Variation in the fatty acid binding protein 2 gene is not associated with markers of metabolic syndrome in patients with coronary heart disease. (PubMed id 12189904)1, 3, 6 Erkkila A.T....Uusitupa M.I. (2002)
- [Genetic polymorphism of pyruvate dehydrogenase kinase 4 (PDK4), paraoxonase 2 (PON2), and fatty acid binding protein 2 (FABP2) in the NIDDM population of Senegal] (PubMed id 15776585)1, 3, 6 Che D....Trivin F. (2002)
|
Search for FABP2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing FABP2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing FABP2
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FABP2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for FABP2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for FABP2:

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Incremental update: 13 Oct 2009
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