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Aliases & Descriptions for FABP1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| FABPL 2, 3 | | L-FABP 1, 2, 3 |
| | | Descriptions |
|---|
| Fatty acid-binding protein, liver 2 | | fatty acid binding protein 1, liver 2 |
|
| | Search outside databases for aliases for FABP1 genePrevious GC identifers: GC02M087977 GC02M088715 GC02M088307 GC02M088324 |
Summaries for FABP1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for FABP1: FABP1 encodes the fatty acid binding protein found in liver. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABP1 and FABP6 (the ileal fatty acid binding protein) are also able to bind bile acids. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. [provided by RefSeq] UniProtKB/Swiss-Prot: FABPL_HUMAN, P07148Function: Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transportGene Wiki entry for FABP1 |
Genomic Location for FABP1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the FABP1 gene 
Entrez Gene cytogenetic band: 2p11 Ensembl cytogenetic band: 2p11.2 HGNC cytogenetic band: 2p11FABP1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M088261:
(about GC identifiers)
Start:
|
88,203,625 bp from pter |
End:
|
88,208,693 bp from pter |
Size:
|
5,069 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000002.10 NT_022184.14
| Proteins for FABP1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: FABPL_HUMAN, P07148 (See
protein sequence)Recommended Name: Fatty acid-binding protein, liver Size: 127 amino acids; 14208 Da
Subcellular location: Cytoplasm
PDB structure from and Proteopedia :2F73 (3D)
 2PY1 (3D)
 Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_001434.1
ENSEMBL proteins: ENSP00000377351 ENSP00000295834
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: FABP1 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for FABP1: Assays for FABP1: | Protein
Domains/ Families for FABP1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P07148
ProtoNet protein and cluster: P07148 1 Blocks protein family: IPB000463 Cytosolic fatty-acid binding protein
UniProtKB/Swiss-Prot: FABPL_HUMAN, P07148Domain: Forms a beta-barrel structure that accommodates hydrophobic ligands in its interiorSimilarity: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family | Gene Function for FABP1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC022287
Applied Biosystems Silencer® siRNAs for FABP1
Sigma-Aldrich siRNA for FABP1  Sigma-Aldrich shRNA for FABP1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001443                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001443                                  untagged cDNA clones in CMV expression vector (see all 2): BC022287 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: BC022287
UniProtKB/Swiss-Prot: FABPL_HUMAN, P07148Function: Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transportGenatlas biochemistry entry for FABP1:fatty acid binding protein 1,liver2 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Fabp1):
3 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for FABP1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 2 Sigma-Aldrich "Your Favorite Gene" Pathways for FABP1 (Your Favorite Gene powered by Ingenuity) 
Gene Network CentralTM Interacting Genes and Proteins Network for FABP1 
5/38 Interacting proteins for FABP1 (ENSP000002958343) via UniProtKB, MINT, and/or STRING (see all 38
)About this table
2 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for FABP1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for FABP1 10/21 Novoseek chemical compound relationships for FABP1 gene (see all 21
)
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| fatty acid |
83.24 |
260 |
10064902 (5), 15138477 (5), 1699834 (5), 8664328 (4) (see all 97) |
| oleoyl-coa |
83.14 |
1 |
12479568 (1) |
| 11-(dansylamino)undecanoic acid |
78.80 |
2 |
8053904 (1) |
| sterol |
55.09 |
27 |
8609911 (7), 8895052 (2), 8431458 (2), 7547928 (1) (see all 8) |
| oleic acid |
54.40 |
11 |
10331654 (2), 8262919 (2), 7588781 (1), 11329616 (1) (see all 8) |
| acyl-coa |
53.68 |
9 |
9395205 (1), 17627968 (1), 10428978 (1), 12213584 (1) (see all 6) |
| lipid |
52.53 |
40 |
17698986 (3), 8431458 (3), 8664328 (2), 17605029 (2) (see all 21) |
| phytanic acid |
50.39 |
7 |
15124915 (4), 12176726 (1) |
| phospholipid |
48.51 |
12 |
10941873 (2), 1629224 (2), 8664328 (1), 9765957 (1) (see all 9) |
| 8-oxo-dg |
44.68 |
5 |
16772708 (1), 17954367 (1), 15970406 (1), 16249547 (1) (see all 5) |
About this table
|
Transcripts for FABP1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC022287
Sigma-Aldrich siRNA for FABP1  Sigma-Aldrich shRNA for FABP1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_001443 REFSEQ mRNAs for FABP1 gene: NM_001443.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001443               OriGene GFP tagged cDNA clone in CMV expression vector: NM_001443                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001443                                  untagged cDNA clones in CMV expression vector (see all 2): BC022287  Additional cDNA sequence: BC022287.1 BC032801.1 BX641099.1 CR542090.1 CR590669.1 CR612744.1 M10050.1 M10617.1 14 DOTS entries: DT.87016483 DT.91936262 DT.416902 DT.100743022 DT.416905 DT.100810634 DT.102827676 DT.87001698 DT.91744663 DT.121034754 DT.416906 DT.95094646 DT.95273281 DT.99939343 24/119 AceView cDNA sequences (see all 119
):M10617 CR542090 AV647083 AV655309 AL531613 BM766943 AI742193 R29613 AA099433 BM855492 BC032801 BM768288 AV681776 CR590669 T53220 CR612744 T68121 CB154162 AV647214 NM_001443 AV661404 AI719013 AV657326 BX482137
highest scoring ESTs for FABP1:M10050 AA099433 AA101894 AA343641 AA706930 AA894931 AU098735 AV682257 AV682665 AV685486 Unigene Cluster for FABP1: Fatty acid binding protein 1, liver Hs.380135 [show with all ESTs]Unigene Representative Sequence: BX641099
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for FABP1
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5 | |
| SP1: | |   | |   | |   | - |   | |   | - |   | |   | - |   | - |   | |   | |
| SP2: | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | - |   | |   | - |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for FABP1
2 Ensembl transcripts including schematic representations: ENST00000393750
ENST00000295834
|
Expression for FABP1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| FABP1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for FABP1
1 / 2 / 3 3 probe-sets matching FABP1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: ACATTGGGTG
SOURCE GeneReport for Unigene cluster: Hs.380135
Expression variation in blood from EXPOLDB for FABP1 |
Orthologs for FABP1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for FABP1 gene from 5/10 species (see all 10
)
About this table Species with no ortholog for FABP1
ENSEMBL Gene Tree for FABP1 | Paralogs for FABP1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for FABP1 gene
- FABP62
|
SNPs/Variants for FABP1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for FABP1 (up to first 250kb)
|
Disorders & Mutations for FABP1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 134650
10/26 Novoseek disease relationships for FABP1 gene (see all 26
)
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| fatty liver |
91.43 |
191 |
15138477 (5), 1699834 (5), 2164578 (2), 1711781 (2) (see all 94) |
| renal disease |
47.47 |
36 |
16490622 (6), 12707994 (3), 16860300 (3), 14749682 (3) (see all 15) |
| chronic glomerulonephritis |
44.47 |
5 |
16118482 (1), 16234607 (1), 16249547 (1) |
| proteinuria |
32.39 |
4 |
16118482 (2), 17954367 (1), 18855269 (1) |
| microalbuminuria |
29.78 |
3 |
16236942 (1), 16506273 (1) |
| colorectal cancer |
27.62 |
20 |
10518104 (7), 15138477 (3), 16489072 (1), 2127610 (1) |
| liver damage |
24.97 |
3 |
15696188 (1), 12406996 (1) |
| bowel disease |
18.06 |
2 |
14563446 (1) |
| adenocarcinoma gastric |
16.93 |
3 |
15051923 (1), 16374067 (1) |
| diabetic nephropathies |
13.69 |
8 |
16506273 (2), 16249547 (2) |
About this table
Human Gene Mutation Database: FABP1 Genetic Association Database: FABP1 Human Genome Epidemiology Navigator: FABP1 (8 documents)
|
Medical News for FABP1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for FABP1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/198 PubMed articles for FABP1 gene (see all 198
):- A Thr94Ala mutation in human liver fatty acid-binding protein contributes to reduced hepatic glycogenolysis and blunted elevation of plasma glucose levels in lipid-exposed subjects. (PubMed id 17698986)1, 2, 3 Weickert M.O....Mohlig M. (2007)
- Effect of liver fatty acid binding protein (FABP) T94A missense mutation on plasma lipoprotein responsiveness to treatment with fenofibrate. (PubMed id 15249972)1, 3, 6 Brouillette C....Vohl M.C. (2004)
- Plasma concentrations of apolipoprotein B are modulated by a gene--diet interaction effect between the LFABP T94A polymorphism and dietary fat intake in French-Canadian men. (PubMed id 15308127)1, 3, 6 Robitaille J....Vohl M.C. (2004)
- Intestinal fatty acid binding protein and microsomal triglyceride transfer protein polymorphisms in French-Canadian youth. (PubMed id 15547295)3, 6 Stan S....Levy E. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Human liver fatty acid binding protein gene is located on chromosome 2. (PubMed id 3012800)2, 3 Chen S.H....Chan L. (1986)
- Human liver fatty acid binding protein cDNA and amino acid sequence. Functional and evolutionary implications. (PubMed id 3838309)3, 4 Chan L.... Smith L.C. (1985)
- Human liver fatty acid binding protein. Isolation of a full length cDNA and comparative sequence analyses of orthologous and paralogous proteins. (PubMed id 3838313)3, 4 Lowe J.B....Gordon J.I. (1985)
- Expression of liver fatty acid binding protein alters growth and differentiation of embryonic stem cells. (PubMed id 11354243)1, 3 Schroeder F....Kier A.B. (2001)
- Antioxidative function of L-FABP in L-FABP stably transfected Chang liver cells. (PubMed id 16175609)1, 3 Wang G....Burczynski F.J. (2005)
|
Search for FABP1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing FABP1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing FABP1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FABP1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for FABP1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for FABP1:

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